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Psoriasis treatment guidelines proposed for patients with concomitant HCVEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Topical therapy and ultraviolet B phototherapy should be considered first-line and second-line therapies for patients with limited psoriasis and concomitant hepatitis C virus infection, suggests a consensus report from the Medical Board of the US National Psoriasis Foundation. (Source: MedWire News - Pediatrics)
Source: MedWire News - Pediatrics - November 21, 2009 Category: Pediatrics Source Type: news

Psoriasis treatment guidelines proposed for patients with concomitant HCVEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Topical therapy and ultraviolet B phototherapy should be considered first-line and second-line therapies for patients with limited psoriasis and concomitant hepatitis C virus infection, suggests a consensus report from the Medical Board of the US National Psoriasis Foundation. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - November 21, 2009 Category: Dermatology Source Type: news

Elevated International Normalized Ratio associated with concurrent use of sorafenib and warfarin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A 70-year-old man diagnosed with hepatocellular carcinoma experienced an increase in INR values after the addition of sorafenib to his warfarin regimen. PMID: 19923313 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Moretti LV, Montalvo RO Tags: Am J Health Syst Pharm Source Type: journals

What Role Does the Route of Immunization Play in the Generation of Protective Immunity against Mucosal Pathogens?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The route of vaccination is important in influencing immune responses at the initial site of pathogen invasion where protection is most effective. Immune responses required for mucosal protection can differ vastly depending on the individual pathogen. For some mucosal pathogens, including acute self-limiting infections, high-titer neutralizing Abs that enter tissue parenchyma or transude into the mucosal lumen are sufficient for clearing cell-free virus. However, for pathogens causing chronic infections such as HIV, hepatitis C virus, herpes viruses, mycobacteria, and fungal and parasitic infections, a single arm of th...
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Belyakov IM, Ahlers JD Tags: J Immunol Source Type: journals

Frequency of antibodies against the etiologic agents of acquired imunodeficiency syndrome, syphilis, hepatitis B and C, and Chagas' disease in patients with rheumatic diseases treated with anti-tumor necrosis factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The frequency of seropositivity for different infectious diseases in patients under anti-TNF therapy is low. Individuals with positive serology for hepatitis C deserve close attention. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals

Primary antiphospholipid syndrome and hepatitis B and C infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A small percentage of patients with primary APS had positive serology for hepatitis B and C, and all represented cases post-vaccine or serology scar. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals

Hepatitis C Virus Proteins Induce Lipogenesis and Defective Triglyceride Secretion in Transgenic Mice [Lipids and Lipoproteins: Metabolism, Regulation, and Signaling]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, transgenic mice expressing the HCV full-length polyprotein at low levels have decreased plasma triglyceride levels and develop hepatocellular steatosis in the same way as HCV-infected patients. In these mice, SREBP1c activation by one or several HCV proteins induces de novo triglyceride synthesis via the lipogenic pathway, in a manner independent of ER stress, whereas triglyceride secretion is simultaneously reduced. (Source: Journal of Biological Chemistry)
Source: Journal of Biological Chemistry - November 20, 2009 Category: Chemistry Authors: Lerat, H., Kammoun, H. L., Hainault, I., Merour, E., Higgs, M. R., Callens, C., Lemon, S. M., Foufelle, F., Pawlotsky, J.-M. Tags: Lipids and Lipoproteins: Metabolism, Regulation, and Signaling Source Type: journals

Multitasking may be Achilles heel for hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatitis C, a formidable virus that affects 130 million people worldwide, is nursing some pretty impressive bruises. By knocking out sections and subsections of one of its proteins, scientists reveal weak spots in the viruss armor and gain new momentum for developing drug targets for sufferers of the disease. (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 19, 2009 Category: Biomedical Science Source Type: organizations

DPRK develops reagent for diagnosis of hepatitis C virus antibodyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PYONGYANG, Nov. 19 (Xinhua) -- The Academy of Medical ... (Source: Xinhuanet Chinaview Health)
Source: Xinhuanet Chinaview Health - November 19, 2009 Category: Consumer Health News Tags: Health Source Type: news

G-CSF in Peg-IFN induced neutropenia in liver transplanted patients with HCV recurrence.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: G-CSF administration is effective in the case of Peg-IFN induced neutropenia increasing neutrophil count, prolonging treatment and leading to sustained virological response (SVR) rates comparable to non-neutropenic patients. It prevents the occurrence of de novo autoimmune hepatitis. PMID: 19916175 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Lodato F, Azzaroli F, Tamè MR, Di Girolamo M, Buonfiglioli F, Mazzella N, Cecinato P, Roda E, Mazzella G Tags: World J Gastroenterol Source Type: journals

What are 'true normal' liver stiffness values using FibroScan®?: a prospective study in healthy living liver and kidney donors in South KoreaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To identify the normal range of liver stiffness (LS) values by recruiting healthy living liver and kidney donors in South Korea. Liver stiffness measurement (LSM) was performed in 69 healthy living liver and kidney donors who were admitted for transplantation. None of the subjects suffered from diabetes mellitus, hypertension, hepatitis B virus infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or metabolic syndrome. LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available liver histology, eight showed normal liver histology and four showed liver steatosis of (Source: Liver International)
Source: Liver International - November 19, 2009 Category: Gastroenterology Authors: Seung Up Kim, Gi Hong Choi, Woong Kyu Han, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Jin Sub Choi, Seung Choul Yang, Eun Hee Choi, Sang Hoon Ahn, Kwang-Hyub Han, Chae Yoon Chon Source Type: journals

Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to investigate the paracrine effects of hepatocarcinoma cells on human HSC using a co-culture system. Huh7 or HepG2 cells, human hepatocarcinoma cell lines, were co-cultured with primary human HSC. Intracellular calcium mobilization, proliferation, migration, expression of pro-angiogenic and fibrogenic genes, smooth muscle [alpha]-actin ([alpha]-SMA) protein expression, inflammatory properties (nuclear factor kappa B activation and interleukin 8 secretion) and intracellular signalling pathways (AKT and ERK) were analysed in HSC. Culture of HSC with Huh7 cells for 24 h stimulated HSC proliferation, migratio...
Source: Liver International - November 19, 2009 Category: Gastroenterology Authors: Pau Sancho-Bru, Elena Juez, Montserrat Moreno, Valeria Khurdayan, Manuel Morales-Ruiz, Jordi Colmenero, Vicente Arroyo, David A. Brenner, Pere Ginès, Ramón Bataller Source Type: journals

Immunoadsorption apheresis and immunosuppressive drug therapy in the treatment of complicated HCV-related cryoglobulinemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The immunosuppressive drug therapy (IDT) is not always effective to avoid the development of complications in hepatitis C virus-related cryoglobulinemia (HCV-Cr). Removal of cryoglobulins by therapeutic plasmapheresis is currently accepted. In this randomized, parallel group study, 17 male and female patients aged 43-79 years, with complicated HCV-Cr, were submitted for 12 weeks (initial immunosuppressive therapy) to IDT ([alpha]-interferon, pegylated-interferon [alpha]-2a, cyclophosphamide, methylprednisolone, prednisone, cyclosporine, ribavirin, and melphalan). Then, they were randomly assigned to two parallel groups: A ...
Source: Journal of Clinical Apheresis - November 19, 2009 Category: Hematology Authors: Claudia Stefanutti, Antonio Vivenzio, Serafina Di Giacomo, Giancarlo Labbadia, Fabio Mazza, Giovanna D'Alessandri, Pietro M. Ferraro, Cesare Masala Source Type: journals

Chances and limitations of non-invasive tests in the assessment of liver fibrosis in liver transplant patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kamphues C, Lotz K, Röcken C, Berg T, Eurich D, Pratschke J, Neuhaus P, Neumann UP. Chances and limitations of non-invasive tests in the assessment of liver fibrosis in liver transplant patients.Clin Transplant 2009 DOI:10.1111/j.1399-0012.2009.01152.x© 2009 John Wiley & Sons A/S.Abstract: Because fibrosis progression resulting in liver cirrhosis represents the main reason for graft lost in patients after liver transplantation, an early detection of liver fibrosis is crucial. In recent years, several non-invasive tests for the assessment of liver fibrosis have been developed. We prospectively assessed the stage of liver ...
Source: Clinical Transplantation - November 19, 2009 Category: Transplant Surgery Authors: Carsten Kamphues, Katharina Lotz, Christoph Röcken, Thomas Berg, Dennis Eurich, Johann Pratschke, Peter Neuhaus, Ulf P. Neumann Source Type: journals

Mortality and drug exposure in a 5-year cohort of patients with chronic liver disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Drug exposure in general was not associated with higher mortality except for a few categories. Mortality in patients with chronic liver disease was high and is associated with simple laboratory values. PMID: 19924579 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 19, 2009 Category: Journals (General) Authors: Hug BL, Lipsitz SR, Seger DL, Karson AS, Wright SC, Bates DW Tags: Swiss Med Wkly Source Type: journals

Insulin resistance and geographical origin: major predictors of liver fibrosis and response to peginterferon and ribavirin in HCV-4Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Insulin resistance and geographical origin are major predictors of liver fibrosis and response to peginterferon and ribavirin in HCV-4 patients. Insulin resistance is frequently encountered in these patients, and correlated independently with serum HCV-RNA. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Moucari, R, Ripault, M-P, Martinot-Peignoux, M, Voitot, H, Cardoso, A-C, Stern, C, Boyer, N, Maylin, S, Nicolas-Chanoine, M-H, Vidaud, M, Valla, D, Bedossa, P, Marcellin, P Tags: Cirrhosis Hepatology Source Type: journals

New aspects of an anti-tumour drug: sorafenib efficiently inhibits HCV replicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data demonstrate that the well-characterised anti-tumour drug sorafenib efficiently blocks HCV replication in vitro. This novel effect of sorafenib should be further explored as an antiviral strategy for patients with chronic HCV infection. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Himmelsbach, K, Sauter, D, Baumert, T F, Ludwig, L, Blum, H E, Hildt, E Tags: Hepatology Source Type: journals

Insulin resistance is associated with liver stiffness in HIV/HCV co-infected patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: IR is associated with LS in patients co-infected with HIV/HCV. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Merchante, N, Rivero, A, de los Santos-Gil, I, Merino, D, Marquez, M, Lopez-Ruz, M A, Rodriguez-Bano, J, del Valle, J, Camacho, A, Sanz-Sanz, J, Macias, J, Perez-Camacho, I, Gomez-Mateos, J, Moro, A, Pineda, J A Tags: Hepatology Source Type: journals

HIV/hepatitis C co-infection and hepatic fibrosis: looking beyond HIV-associated immune suppression; the contribution of hepatic steatosis and insulin resistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Bhagani, S. Tags: Commentaries Source Type: journals

Genetic Predictors of Treatment-Induced Viral Clearance in Hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Drs. Dermot McGovern and Gil Melmed comment on a study published in Nature on the ability of an IL-28B polymorphism to predict sustained viral response to hepatitis C treatment. Medscape Genomic Medicine (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - November 18, 2009 Category: Gastroenterology Tags: Pathology & Lab Medicine Source Type: info

InterMune Shares Fall on Change in Hepatitis StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
From Associated Press (November 17, 2009) NEW YORK--Shares of InterMune Inc. fell Tuesday after the biotechnology company said it would discontinue a high-dose of its experimental Hepatitis C treatment in a study because of potential liver... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 18, 2009 Category: Pharmaceuticals Source Type: news

Evidence of recombination in Hepatitis C Virus populations infecting a hemophiliac patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although recombination may not appear to be common among natural populations of HCV it should be considered as a possible mechanism for generating genetic diversity in hemophiliacs patients. (Source: Virology Journal)
Source: Virology Journal - November 18, 2009 Category: Virology Authors: Pilar MorenoMacarena AlvarezLilia LopezGonzalo MoratorioDidier CasaneMatias CastellsSilvia CastroJuan CristinaRodney Colina Source Type: journals

Survey of both hepatitis B virus (HBsAg) and hepatitis C virus (HCV-Ab) coinfection among HIV positive patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion There was a significant correlation between coinfection with HCV and HBV and/or both among HIV-positive patients depending on different variables including sex, age, occupation, marital status ,exposure to risk factors.(p (Source: Virology Journal)
Source: Virology Journal - November 18, 2009 Category: Virology Authors: Mohsen MohammadiGholamreza TaleiAli SheikhianFarzad EbrahimzadeYadollah PourniaEhsan GhasemiHadis Boroun Source Type: journals

Viruses within the Flaviviridae Decrease CD4 Expression and Inhibit HIV Replication in Human CD4+ Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Viral infections alter host cell homeostasis and this may lead to immune evasion and/or interfere with the replication of other microbes in coinfected hosts. Two flaviviruses are associated with a reduction in HIV replication or improved survival in HIV-infected people (dengue virus (DV) and GB virus type C (GBV-C)). GBV-C infection and expression of the GBV-C nonstructural protein 5A (NS5A) and the DV NS5 protein in CD4(+) T cells inhibit HIV replication in vitro. To determine whether the inhibitory effect on HIV replication is conserved among other flaviviruses and to characterize mechanism(s) of HIV inhibition, the ...
Source: Journal of Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Xiang J, McLinden JH, Rydze RA, Chang Q, Kaufman TM, Klinzman D, Stapleton JT Tags: J Immunol Source Type: journals

Hepatitis C- and Human Immunodeficiency Virus-Induced Hypersensitivity VasculitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Clinical Pathology ConferenceDOI 10.1007/s11420-009-9141-8Authors Roodabeh Michelle Koolaee, St. Luke’s–Roosevelt Hospital Center Department of Internal Medicine 1000 10th Avenue New York NY 10019 USAOra Singer, Hospital for Special Surgery Department of Rheumatology 535 East 70th Street New York NY 10021 USAAnne Bass, Hospital for Special Surgery Department of Rheumatology 535 East 70th Street New York NY 10021 USARobert Winchester, Columbia University New York Presbyterian Hospital Department of Rheumatology 630 West 168th Street New York NY 10032 USASurya Seshan, Weill-Cornel...
Source: HSS Journal - November 17, 2009 Category: Orthopaedics Tags: HSS Journal Source Type: journals

Treatment of Chronic Hepatitis C in a Patient Affected by Systemic SclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The currently recommended treatment for patients infected with hepatitis C virus (HCV) is pegilated interferon α (IFN α) plus ribavirin. Despite the numerous benefits of this therapy, there is an increasing concern regarding his tolerance. Among the most common side effects, interferon may trigger the onset or exacerbation of autoimmune diseases. When chronic hepatitis C coexists with an autoimmune disorder, it is not clear whether using interferon is better than avoiding it. We evaluated the disease state of a 55-year old female affected by sistemic sclerosis (SSc), during and after therapy with IFN;...
Source: Gastroenterology Research and Practice - November 17, 2009 Category: Gastroenterology Source Type: journals

Pioglitazone improves virological response to peginterferon α-2b/ribavirin combination therapy in hepatitis C genotype 4 patients with insulin resistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Insulin resistance (IR) affects sustained virological response (SVR). The use of insulin-sensitizing agents has been proposed to improve therapy outcome. The safety and efficacy of pioglitazone on insulin sensitivity and SVR in treatment-naïve patients with chronic hepatitis C (CHC) genotype 4 with IR receiving standard antiviral therapy were evaluated in a randomized-controlled study. Ninety-seven previously untreated patients with CHC and IR [homeostasis model assessment (HOMA>2)] were randomly assigned into two arms; (arm A; n=48) were given pioglitazone 30 mg/day combined with peginterferon (Peg-IFN)-[alpha]-2b/ribavi...
Source: Liver International - November 17, 2009 Category: Gastroenterology Authors: Mahmoud Khattab, Mohammed Emad, Asharf Abdelaleem, Mohammed Eslam, Rabab Atef, Yehia Shaker, Lamia Hamdy Source Type: journals

A simple, noninvasive test for the diagnosis of liver fibrosis in patients with hepatitis C recurrence after liver transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary. Recurrent hepatitis C is a common cause of graft loss in patients undergoing liver transplantation, and serial protocol liver biopsies have been used to identify patients at risk of graft loss from rapid fibrosis progression. The aim of this study was to derive a simple noninvasive index to predict fibrosis in patients with recurrent hepatitis C post-transplant. A retrospective study was performed assessing serial liver biopsies for post-transplant chronic hepatitis C infection. One hundred eighty-five patients were included in the analysis; median age 53 years (interquartile range 48[ndash]59) and 140 (76%) were ...
Source: Journal of Viral Hepatitis - November 17, 2009 Category: Infectious Diseases Authors: T. J. S. Cross, V. Calvaruso, M. R. Foxton, P. Manousou, A. Quaglia, F. Grillo, A. P. Dhillon, J. Nolan, T. P. Chang, J. O'Grady, M. A. Heneghan, J. P. O'Beirne, A. K. Burroughs, P. M. Harrison Source Type: journals

Review: Acute hepatitis C and HIV co-infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Lancet Infectious Diseases Area: News The Lancet Infectious Diseases has featured a review, starting with a case vignette of the presentation of a patient with HIV co-infection with hepatitis C, and describes the immunology, natural history, and epidemiology of acute hepatitis C and co-infection with HIV. Treatment options for the medical management of acute hepatitis C and co-infection with HIV have also been featured. (Source: NeLM - News)
Source: NeLM - News - November 17, 2009 Category: Drugs & Pharmacology Source Type: organizations

Can hepatitis C virus prevalence be used as a measure of injection-related human immunodeficiency virus risk in populations of injecting drug users? An ecological analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background Human immunodeficiency virus (HIV) outbreaks occur among injecting drug users (IDUs), but where HIV is low insight is required into the future risk of increased transmission. The relationship between hepatitis C virus (HCV) and HIV prevalence among IDUs is explored to determine whether HCV prevalence could indicate HIV risk.Methods Systematic review of IDU HIV/HCV prevalence data and regression analysis using weighted prevalence estimates and time[ndash]series data.Results HIV/HCV prevalence estimates were obtained for 343 regions. In regions other than South America/sub-Saharan Africa (SAm/SSA), mean IDU HIV ...
Source: Addiction - November 17, 2009 Category: Addiction Authors: Peter Vickerman, Matthew Hickman, Margaret May, Mirjam Kretzschmar, Lucas Wiessing Source Type: journals

The Utility of Therapeutic Drug Monitoring for Ribavirin in Patients with Chronic Hepatitis C--A Critical Review (December) (CE).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There is conflicting evidence about the existence of a correlation between ribavirin concentrations and virologic response or development of toxicity. This inconsistent evidence, coupled with the currently employed effective strategies that maximize sustained virologic response and minimize development of anemia, precludes the utility of TDM for ribavirin. PMID: 19920162 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 17, 2009 Category: Drugs & Pharmacology Authors: Chan AH, Partovi N, Ensom MH Tags: Ann Pharmacother Source Type: journals

Easing Hepatitis Treatment?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
My son, a 29-year-old hemophiliac, will be undergoing treatment for hepatitis C with interferon and ribavirin. What can he do or take to ease the debilitating side effects? (Source: Dr. Weil Q&A)
Source: Dr. Weil Q&A - November 16, 2009 Category: Consumer Health Advice Source Type: info

Hepatitis C Screening Of Mothers Using Methadone And Their Babies Is Inadequate, AustraliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Screening for Hepatitis C virus (HCV) infection among pregnant women on methadone maintenance treatment and their infants is inadequate, according to the authors of a study published in the Medical Journal of Australia. Dr Ralph Nanan, Professor of Paediatrics at the University of Sydney, and his co-authors undertook a retrospective review of medical records from two major hospitals in Sydney and a hospital in rural NSW. (Source: Liver Disease / Hepatitis News From Medical News Today)
Source: Liver Disease / Hepatitis News From Medical News Today - November 16, 2009 Category: Gastroenterology Tags: Liver Disease / Hepatitis Source Type: news

Hepatitis C Screening Of Mothers Using Methadone And Their Babies Is Inadequate, AustraliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Screening for Hepatitis C virus (HCV) infection among pregnant women on methadone maintenance treatment and their infants is inadequate, according to the authors of a study published in the Medical Journal of Australia. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 16, 2009 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news

[] Acute hepatitis C and HIV coinfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a man infected with HIV with sexually acquired acute hepatitis C and discuss the immunology, natural history, and epidemiology of acute hepatitis C and coinfection with HIV. Several recent reports have documented acute hepatitis C among men who have sex with men who engage in high risk sexual practices and often have concomitant genital ulcer disease. We review treatment options for the medical management of acute hepatitis C and coinfection with HIV. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - November 16, 2009 Category: Infectious Diseases Authors: Jodie Dionne-Odom, Melissa K Osborn, Henry Radziewicz, Arash Grakoui, Kimberly Workowski Source Type: journals

Screening for hepatitis C virus infection in methadone-maintained mothers and their infants.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Screening for HCV infection in the high-risk population of pregnant women on methadone maintenance treatment and their infants is inadequate. This could lead to significant underdetection of active HCV infection in this high-risk population, and their infants. Current screening guidelines may therefore need to be revised. PMID: 19912084 [PubMed - in process] (Source: Med J Aust)
Source: Med J Aust - November 16, 2009 Category: Journals (General) Authors: Liu AJ, An EI, Murray HG, Tetstall E, Leroi MJ, Nanan RK Tags: Med J Aust Source Type: journals

The role of general practitioners in managing and treating hepatitis C.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
General practitioners hold the key to expanding access to treatment. PMID: 19912079 [PubMed - in process] (Source: Med J Aust)
Source: Med J Aust - November 16, 2009 Category: Journals (General) Authors: Hellard ME, Wang YH Tags: Med J Aust Source Type: journals

Association among Fas expression in leucocytes, serum Fas and Fas-ligand concentrations and hepatic inflammation and fibrosis in chronic hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Replication of the hepatitis C virus (HCV) in peripheral blood mononuclear cells (PBMC) may impair immune functions and establish persistent infection. The aim of this study was to assess the influence of HCV on PBMC and their susceptibility to apoptosis in relation to liver inflammation and fibrosis. Eighty-one patients with chronic hepatitis C (CHC) were enrolled in this study. Flow cytometry was used to determine the amount of T cells (CD4+, CD8+), B cells (CD19+), monocytes (CD14+) and natural killer cells (CD16+) in the peripheral blood and the expression of CD95+ (CD95/APO-1) in each subset. Serum concentrations of s...
Source: Liver International - November 16, 2009 Category: Gastroenterology Authors: Anatol Panasiuk, Anna Parfieniuk, Janusz Zak, Robert Flisiak Source Type: journals

Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Apparent mutational escape can occur in MHC class II-restricted epitopes, but this is uncommon when compared with class I-restricted epitopes in the same individual. This indicates that other mechanisms for silencing CD4 T cells are dominant in persistent HCV infections. (HEPATOLOGY 2009.) (Source: Hepatology)
Source: Hepatology - November 16, 2009 Category: Internal Medicine Authors: Michael J. Fuller, Naglaa H. Shoukry, Toshifumi Gushima, David G. Bowen, Benoit Callendret, Katherine J. Campbell, Dana L. Hasselschwert, Austin L. Hughes, Christopher M. Walker Source Type: journals

The high-risk recipient: the Eighth Annual American Society of Transplant Surgeons' State-of-the-Art Winter SymposiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion focused on various types of high-risk recipients, such as those with coronary artery disease, morbid obesity, and hepatitis C; strategies to reduce risk, such as down-staging of hepatocellular carcinoma and treatment of pulmonary hypertension; the development of alternatives to transplantation; and the degree to which risk can or should be used to define candidate selection. These approaches can modify the impact of recipient risk on transplant outcomes and permit transplantation to be applied successfully to a greater variety of patients. (Source: Clinical Transplantation)
Source: Clinical Transplantation - November 16, 2009 Category: Transplant Surgery Authors: Randall S. Sung, Elizabeth A. Pomfret, Kenneth A. Andreoni, Talia B. Baker, Thomas G. Peters Source Type: journals

Serum Concentrations of Interleukin 1{beta}, CXCL10, and Interferon-{gamma} in Mixed Cryoglobulinemia Associated with Hepatitis C Infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Serum levels of IL-1ss and CXCL10 were high in patients with MC+HCV. Increased CXCL10 and IL-1ss levels were associated with the presence of active vasculitis in MC+HCV patients. PMID: 19918044 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 16, 2009 Category: Rheumatology Authors: Antonelli A, Ferri C, Ferrari SM, Ghiri E, Marchi S, Sebastiani M, Fallahi P Tags: J Rheumatol Source Type: journals

Psoriasis treatment guidelines proposed for patients with concomitant HCVEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Topical therapy and ultraviolet B phototherapy should be considered first-line and second-line therapies for patients with limited psoriasis and concomitant hepatitis C virus infection, suggests a consensus report from the Medical Board of the US National Psoriasis Foundation. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - November 14, 2009 Category: Dermatology Source Type: news

Psoriasis treatment guidelines proposed for patients with concomitant HCVEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Topical therapy and ultraviolet B phototherapy should be considered first-line and second-line therapies for patients with limited psoriasis and concomitant hepatitis C virus infection, suggests a consensus report from the Medical Board of the US National Psoriasis Foundation. (Source: MedWire News - Psoriasis)
Source: MedWire News - Psoriasis - November 14, 2009 Category: Dermatology Source Type: news

The role of hepcidin in iron metabolism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory. PMI...
Source: Acta Haematologica - November 13, 2009 Category: Hematology Authors: Nemeth E, Ganz T Tags: Acta Haematol Source Type: journals

The Evolutionary Dynamics of a Rapidly Mutating Virus within and between Hosts: The Case of Hepatitis C VirusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author Summary Rapidly mutating viruses, such as hepatitis C virus, can escape host immunity by generating new strains that avoid the immune system. Existing data support the idea that such within-host evolution affects the outcome of the infection. Few theoretical models address this question and most follow viral diversity or qualitative traits, such as drug resistance. Here, we study the evolution of two virus quantitative traits—the replication rate and the ability to be recognised by the immune response—during an infection. We develop an epidemiological framework where transmission events are driven by within-hos...
Source: PLoS Computational Biology - November 13, 2009 Category: Biology Authors: Fabio Luciani et al. Source Type: journals

Declining hepatitis C virus (HCV) prevalence in pregnant women: impact of anti-HCV screening of donated blood.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Anti-HCV screening of donated blood and hygienic improvements have markedly decreased HCV infection of pregnant women with a transfusion history; however, 70% of anti-HCV-reactive women were deemed to be infected via routes other than transfusion. PMID: 19912584 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 13, 2009 Category: Hematology Authors: Ohto H, Ishii T, Kitazawa J, Sugiyama S, Ujiie N, Fujimori K, Ariga H, Satoh T, Nollet KE, Okamoto H, Hoshi T Tags: Transfusion Source Type: journals

Reliability of the bright liver echo pattern in diagnosing steatosis in patients with cryptogenic and HCV-related hypertransaminasaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In CCH the BL echo pattern has excellent reliability in diagnosing steatosis, better than in HCV hypertransaminasaemia because of the higher prevalence and extent of steatosis. (Source: Clinical Radiology)
Source: Clinical Radiology - November 12, 2009 Category: Radiology Authors: M. Soresi, L. Giannitrapani, A.M. Florena, E. La Spada, V. Di Gesaro, F. Rappa, A. Alessandri, S. Tripi, M. Romano, G. Montalto Tags: Original Articles Source Type: journals

Ribavirin Dose Reduction Raises Relapse Rate Dose-Dependently in Genotype 1 Patients With Hepatitis C Responding to Pegylated Interferon Alpha-2b Plus RibavirinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study assessed the impact of ribavirin exposure on virologic relapse in combination therapy with pegylated interferon (Peg-IFN) and ribavirin for patients with chronic hepatitis C genotype 1. Journal of Viral Hepatitis (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - November 12, 2009 Category: Drugs & Pharmacology Tags: Gastroenterology Source Type: info

Lamiridosins, Hepatitis C Virus Entry Inhibitors from Lamium albumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Natural Products, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Natural Products)
Source: Journal of Natural Products - November 11, 2009 Category: Biochemistry Tags: article Source Type: journals

Rituximab/immunosuppressants: Resurgence of hepatitis C infection: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 11, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals