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Request for Proposals: National Marfan Foundation/Canadian Marfan Association Faculty Grant Program
The National Marfan Foundation (NMF) is pleased to partner with the Canadian Marfan Association (CMA) to support Marfan syndrome and related disorders research.  Applications are being requested for two-year grants for basic or clinical research.  The grant program is designed to provide financial support for faculty studying any or all disciplines involved in Marfan syndrome and related disorders.  Grant awards are based on proposal evaluation by the NMF Scientific Advisory Board with the approval of the NMF Board of Directors.  The NMF and the CMA will co-fund one two-year grant for $100,000. ...
Source: ScanGrants feed - February 4, 2013 Category: Research Authors: National Marfan Foundation/Canadian Marfan Association Source Type: funding

Request for Proposals: National Marfan Foundation Early Investigator Grant Program
The National Marfan Foundation (NMF) is pleased to announce its newest grant program for the early investigator.  Applications are new being accepted for two-year grants in basic or clinical research on Marfan syndrome and related disorders.  A total of three two-year grants for $37,500 per year for a total of $75,000 per grant will be awarded.  The NMF's grant program is designed to provide financial support for early investigators studying any or all disciplines involved in this area.  The principal investigator must hold an MD, DO, PhD, ScD, DDS, DVM or equivalent degree.  The investiga...
Source: ScanGrants feed - February 4, 2013 Category: Research Authors: National Marfan Foundation Source Type: funding

Teaching NeuroImages: Intracranial hypotension in a patient with Marfan syndrome
An 18-year-old man with Marfan syndrome and migraine headaches presented with acute worsening of headaches with postural changes following spinal fusion surgery for scoliosis. Lumbar spine MRI done before surgery showed diffuse dural ectasia (figure 1). Brain MRI after surgery showed distended transverse and sagittal dural venous sinuses1 and an enlarged pituitary gland suggesting intracranial hypotension (figure 2). He was treated conservatively with rest, fluids, and caffeine. Patients with Marfan syndrome frequently have dural ectasia2 and are at risk of CSF leaks after spinal surgery leading to intracranial hypotension...
Source: Neurology - July 24, 2016 Category: Neurology Authors: Abu Libdeh, A., Matsumoto, J. A., Dhamija, R. Tags: All Headache, Low pressure syndrome, MRI RESIDENT AND FELLOW SECTION Source Type: research

Call for Applications: Marfan Foundation Faculty Grant Program
The faculty grant program supports two-year grants for basic or clinical research for all disciplines in Marfan syndrome and related disorders. Our Scientific Advisory Board evaluates proposals and award grants with the approval of our Board of Directors. We co-fund one two-year grant for $100,000 with the Canadian Marfan Association. The Canadian Marfan Association funding is provided by the Temerty Family Foundation. We award an additional one or two-year $100,000. Eligibility criteria: The principal investigator must hold an MD, DO, PhD, ScD, DDS, DVM, or equivalent degree. The investigator must have prov...
Source: ScanGrants feed - February 6, 2014 Category: Research Authors: Marfan Foundation Source Type: funding

Echocardiographic Methods, Quality Review, and Measurement Accuracy in a Randomized Multicenter Clinical Trial of Marfan Syndrome
Background: The Pediatric Heart Network is conducting a large international randomized trial to compare aortic root growth and other cardiovascular outcomes in 608 subjects with Marfan syndrome randomized to receive atenolol or losartan for 3 years. The authors report here the echocardiographic methods and baseline echocardiographic characteristics of the randomized subjects, describe the interobserver agreement of aortic measurements, and identify factors influencing agreement.Methods: Individuals aged 6 months to 25 years who met the original Ghent criteria and had body surface area–adjusted maximum aortic root diamete...
Source: Journal of the American Society of Echocardiography - April 12, 2013 Category: Cardiology Authors: Elif Seda Selamet Tierney, Jami C. Levine, Shan Chen, Timothy J. Bradley, Gail D. Pearson, Steven D. Colan, Lynn A. Sleeper, M. Jay Campbell, Meryl S. Cohen, Julie De Backer, Lin T. Guey, Haleh Heydarian, Wyman W. Lai, Mark B. Lewin, Edward Marcus, Christ Tags: Marfan Syndrome Source Type: research

Increased frequency of FBN1 truncating and splicing variants in Marfan syndrome patients with aortic events
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Source: Genetics in Medicine - March 3, 2015 Category: Genetics & Stem Cells Authors: Linnea M. BaudhuinKatrina E. KotzerSusan A. Lagerstedt Tags: aortic dissection aortic surgery FBN1 fibrillin-1 Marfan syndrome Source Type: research

Authors' reply Re: 'Peripartum type B aortic dissection in patients with Marfan syndrome who underwent aortic root replacement: a case series study'.
, Osuga Y, Fujii T PMID: 28799184 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - August 10, 2017 Category: OBGYN Authors: Authors' reply Re: 'Peripartum type B aortic dissection in patients with Marfan syndrome who underwent aortic root replacement: a case series study'. Tags: BJOG Source Type: research

Call for Applications: Marfan Foundation Victor A. McKusick Fellowship
The Victor A. McKusick Fellowship is a two-year-award available for PhDs for up to $50,000 per year and MD’s up to $75,000 per year. Fellows up to postgraduate year six are considered. Through this fellowship, we hope to cultivate promising young physician scientists or research scientists conducting basic, translational or clinical research in the field of Marfan syndrome and related disorders, and to stimulate their advancement toward independent research in this field. During the fellowship phase, the applicant is required to work with a mentor who can provide a training environment conducive to beginning a c...
Source: ScanGrants feed - February 6, 2014 Category: Research Authors: Marfan Foundation Source Type: funding

Call for Applications: Marfan Foundation Early Investigator Grant Program
Our newest grant program provides financial support for early investigators studying any or all disciplines involved in Marfan syndrome or a related disorder. Three two-year grants for $37,500 per year for a total of $75,000 per grant are awarded for basic or clinical research. Eligibility criteria: The principal investigator must hold an MD, DO, PhD, ScD, DDS, DVM, or equivalent degree. The investigator must have proven ability to pursue independent research as evidenced by original research publications in peer-reviewed journals. Applicants must have less than seven years experience in a faculty position and h...
Source: ScanGrants feed - February 6, 2014 Category: Research Authors: Marfan Foundation Source Type: funding

Optimizing evaluation in pediatric and young adult patients with Marfan syndrome: Novel longitudinal metrics to track growth of aortic structures
Surveillance metrics in pediatric and young adult Marfan syndrome (pMFS) are challenging. We evaluated the utility of aortic root cross-sectional area/height index (CSA/Ht) on echocardiogram among pMFS patients as a risk stratification and surgical triage metric.
Source: The Journal of Thoracic and Cardiovascular Surgery - March 15, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Salima Ahmed Bhimani, Abdelrahman Rahmy, Suzie Kim, Justin B. Jin, Kenneth Zahka, Rukmini Komarlu, Lars G. Svensson, Amol Pande, Tara Karamlou, Members of Marfan Working Group, Jeevanantham Rajeswaran, Vidayasagar Kalahasti, Milind Desai, Eric Roselli, Mi Tags: Congenital Source Type: research

Metabolic syndrome and associated factors among outpatients of Jimma University Teaching Hospital
Conclusion: It is demonstrated that metabolic syndrome is prevalent in adult outpatients in Jimma and increases as age increases; it is more common among females than males. Among the five diagnostic criteria for metabolic syndrome, hypertension, hyperglycemia, and low HDL-cholesterol were the most prevalent. As metabolic syndrome is rising at an alarming rate, we recommend that relevant prevention, diagnostics, and therapy in adult outpatients are undertaken. Keywords: metabolic syndrome, Jimma, outpatients, high-density lipoprotein, obesity
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - March 4, 2016 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

Metabolic syndrome and C-reactive protein in bank employees
Conclusion: us-CRP was strongly associated with the presence of MS and MS criteria in this group of workers. us-CRP is a useful and effective marker for identifying the development of MS and may be used as a reference in routine care. Keywords: C-reactive protein, bank employees, metabolic syndrome, inflammation mediators, occupational health
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - May 10, 2016 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks
Conclusion: Overall, LighterLife Total could be an effective weight-loss strategy in overweight/obese women with PCOS. However, further investigations are needed to achieve a thorough way of understanding the physiology of weight loss in PCOS. Keywords: obesity, PCOS, LighterLife, VLCD
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - October 14, 2015 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

Evaluating the impact of type 2 diabetes mellitus on cardiovascular risk in persons with metabolic syndrome using the UKPDS risk engine
Conclusion: MS was more common in subjects with T2DM compared with controls (irrespective of the diagnostic criteria used) and MS appears to increase the risk of a coronary event in subjects with T2DM by threefold. Also from this study, MS did not appear to cause an additional increase in the risk of stroke in subjects with T2DM.Keywords: diabetes mellitus, metabolic syndrome, coronary heart disease, cardiovascular disease, UKPDS risk engine
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - September 15, 2015 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

Trends of vascular surgery procedures in Marfan syndrome and Ehlers-Danlos syndrome.
CONCLUSIONS: Patients with Marfan syndrome and Ehlers-Danlos syndrome differ from other patients undergoing vascular surgical procedures, with a significantly higher proportion of aortic procedures including open aneurysm repair and thoracic endovascular aortic repair. While they are younger with fewer comorbidities, due to the unique pathogenesis of their underlying connective tissue disorder, there is an overall higher rate of procedural complications and increased length of stay and cost for Marfan syndrome patients undergoing aortic surgery. PMID: 32423364 [PubMed - as supplied by publisher]
Source: Vascular - May 18, 2020 Category: Surgery Authors: Jayarajan SN, Downing BD, Sanchez LA, Jim J Tags: Vascular Source Type: research