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Prevalence of faecal carriage of Enterobacteriaceae with NDM-1 carbapenemase at military hospitals in Pakistan, and evaluation of two chromogenic mediaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This study shows a high prevalence of multidrug-resistant Enterobacteriaceae with the NDM-1 enzyme in Rawalpindi. The new chromogenic medium, ID Carba, was more sensitive than Colorex KPC and has potential as a screening medium for isolation of Enterobacteriaceae harbouring the NDM-1 enzyme. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - September 13, 2011 Category: Microbiology Authors: Perry, J. D., Naqvi, S. H., Mirza, I. A., Alizai, S. A., Hussain, A., Ghirardi, S., Orenga, S., Wilkinson, K., Woodford, N., Zhang, J., Livermore, D. M., Abbasi, S. A., Raza, M. W. Tags: Original research Source Type: research

In vitro evaluation of antibiotic synergy for NDM-1-producing EnterobacteriaceaeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Synergistic activity was observed for colistin and fosfomycin, and colistin and tigecycline in rare cases, most of the interactions being indifferent. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - September 13, 2011 Category: Microbiology Authors: Bercot, B., Poirel, L., Dortet, L., Nordmann, P. Tags: Original research Source Type: research

Unravelling Of NDM-1 Structure Signals Breakthrough In Fight Against Vicious SuperbugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
News of a significant breakthrough in the fight against drug-resistant infections arrived this week in the form of a paper in the online journal Acta Crystallographica Section F: Structural Biology and Crystallization Communications where researchers describe how they unravelled the structure of NDM-1, a vicious type of superbug that is currently resistant to our most powerful antibiotics. Drug resistance in infectious bacteria is on the rise, posing a serious threat to human health... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 7, 2011 Category: Consumer Health News Tags: MRSA / Drug Resistance Source Type: news

New knowledge will boost fight against superbugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A breakthrough in the fight against drug-resistant infections is one step closer following the discovery of the structure of NDM-1: a vicious form of bacteria that is currently resistant to the most powerful antibiotics available. (Source: Medical Research Council Press Releases)
Source: Medical Research Council Press Releases - September 6, 2011 Category: Consumer Health News Source Type: news

Update in Adult Urinary Tract InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Urinary tract infection remains a common problem for many populations. Recent studies have expanded our understanding of the host innate immune response and its role in the familial association observed for recurrent uncomplicated urinary tract infection in healthy women. Therapeutic management for uncomplicated infection has been compromised by increasing antimicrobial resistance, particularly global dissemination of the CTXM-15 extended spectrum β-lactamase (ESBL) producing Escherichia coli ST-131 strain. Prevention strategies exploring non-antimicrobial approaches continue to show limited promise...
Source: Current Infectious Disease Reports - September 5, 2011 Category: Infectious Diseases Tags: Current Infectious Disease Reports Source Type: research

Development of TaqMan real-time polymerase chain reaction for the detection of the newly emerging form of carbapenem resistance gene in clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumanniiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The study demonstrates that real-time PCR assay based on TaqMan chemistry is a useful technique for the detection of bla NDM-1 harbouring clinical isolates of E. coli, K. pneumoniae and A. baumannii. The assay has great precision in measuring the number of bla NDM-1 gene copies per specimen of DNA. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 16, 2011 Category: Microbiology Authors: V ManchandaS RaiS GuptaRS RautelaR ChopraDS RawatN VermaNP SinghIR KaurP Bhalla Source Type: research

Current Trends in β-Lactam Based β-Lactamases Inhibitors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides a survey of patent and scientific literature for β-lactamase inhibitors discovered in the period 2006 - 2010. PMID: 21838683 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - August 14, 2011 Category: Chemistry Authors: Biondi S, Long S, Panunzio M, Qin WL Tags: Curr Med Chem Source Type: research

Increasing prevalence and dissemination of NDM-1 metallo-{beta}-lactamase in India: data from the SMART study (2009)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A range of carbapenemase genes, associated with diverse ESBLs and/or AmpC backgrounds, were found among Enterobacteriaceae isolated during the study. Many of these ertapenem non-susceptible strains were clonally related and carried various combinations of β-lactamases. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - August 8, 2011 Category: Microbiology Authors: Lascols, C., Hackel, M., Marshall, S. H., Hujer, A. M., Bouchillon, S., Badal, R., Hoban, D., Bonomo, R. A. Tags: Original research Source Type: research

Phylogenetic diversity of Escherichia coli strains producing NDM-type carbapenemasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The E. coli isolates producing NDM-1 carbapenemase belonged to six sequence types and included diverse clonal lineages. Nevertheless, isolates of B1-ST101 accounted for half the collection, and included isolates from both England and Pakistan. None of the isolates belonged to ST131 or to phylogroup B2. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - August 8, 2011 Category: Microbiology Authors: Mushtaq, S., Irfan, S., Sarma, J. B., Doumith, M., Pike, R., Pitout, J., Livermore, D. M., Woodford, N. Tags: Original research Source Type: research

Long-term carriage of NDM-1-producing Escherichia coliEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - August 8, 2011 Category: Microbiology Authors: Poirel, L., Herve, V., Hombrouck-Alet, C., Nordmann, P. Tags: Research letters Source Type: research

Dissemination of the NDM-2-producing Acinetobacter baumannii clone in an Israeli Rehabilitation Center.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study described the clonal dissemination of a NDM-2-producing A. baumannii in an Israeli rehabilitation ward and the genetic surrounding of the gene. The bla(NDM-2) gene was surrounded by the ble and trpF genes downstream and two copies of the ISAba125 in both sides. These are the first NDM-producing A. baumannii strains in Israel from patients with no previous travel or hospitalization in the India subcontinent. PMID: 21825296 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - August 7, 2011 Category: Microbiology Authors: Espinal P, Fugazza G, López Y, Kasma M, Lerman Y, Malhotra-Kumar S, Goosens H, Carmeli Y, Vila J Tags: Antimicrob Agents Chemother Source Type: research

[Correspondence] Balkan NDM-1: escape or transplant?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Enterobacteriaceae with resistance to carbapenems conferred by NDM-1 are potentially a major global health problem. Findings from a survey in 29 European countries show that two of 38 people with NDM-1-producing Enterobacteriaceae had travelled to, or were admitted to hospital in, Kosovo. The spread of NDM-1 into Kosovo is very worrying, especially given that the presence of NDM-1 strains cannot be confirmed because no laboratory detection guidelines exist. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - July 26, 2011 Category: Infectious Diseases Authors: Agreta Gecaj-Gashi, Antigona Hasani, Burbuqe Bruqi, Gjyle Mulliqi-Osmani Tags: Correspondence Source Type: research

Molecular analysis of NDM-1-producing enterobacterial isolates from Geneva, SwitzerlandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This work constitutes the first identification of NDM-1 producers in Switzerland. Interestingly, patients from whom these NDM-1-producing isolates were recovered had a link with the Indian subcontinent or the Balkans. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - July 10, 2011 Category: Microbiology Authors: Poirel, L., Schrenzel, J., Cherkaoui, A., Bernabeu, S., Renzi, G., Nordmann, P. Tags: Original research Source Type: research

Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli by high-throughput genome sequencing.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The resistome of the multidrug-resistant Escherichia coli strain 271 carrying the plasmid-mediated carbapenemase gene bla(NDM-1) was analyzed by high throughput genome sequencing. The p271A plasmid carrying the bla(NDM-1) gene was 35.9 kb in-size and possessed an IncN-type backbone that harbored a novel replicase gene. Acquisition of the bla(NDM-1) gene on plasmid p271A had been likely the result of a cointegration event involving the transposase of Tn5403. The expression of bla(NDM-1) was associated to the insertion sequence ISAba125 likely originating from Acinetobacter baumannii. E. coli 271 accumulated multiple res...
Source: Antimicrobial Agents and Chemotherapy - July 10, 2011 Category: Microbiology Authors: Poirel L, Bonnin RA, Nordmann P Tags: Antimicrob Agents Chemother Source Type: research

Drug 'Shield' Helps Target Antibiotic Resistant BacteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new technique which targets antibiotic-resistant bacteria and shields patients from the toxic parts of an antibiotic drug has been developed by Cardiff University scientists. Dr Elaine Ferguson from Cardiff University's School of Dentistry has utilised a new technique which attaches tiny nano-sized biodegradable polymers to the antibiotic drug - colistin. Use of the drug colistin to fight infection has been limited as it is known to be toxic to the kidneys and nerves despite the fact that it has been found to be effective against new multi-drug resistant bacteria, like NDM-1... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 10, 2011 Category: Consumer Health News Tags: MRSA / Drug Resistance Source Type: news

First description of an Escherichia coli strain producing NDM-1 carbapenemase in Spain.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A carbapenem-resistant Escherichia coli (DVR22) was recovered from a stool specimen from a patient with traveler's diarrhea who had traveled to India. Molecular screening led to the first identification of NDM-1 in Spain. The bla(NDM-1) gene was located in a conjugative plasmid of ca. 300 kb also containing the bla(CTX-M-15), bla(TEM-1), Δbla(DHA-1) and armA genes. In addition, bla(NDM-1) was preceded by an ISAba125 insertion element only found in Acinetobacter spp. PMID: 21730115 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - July 4, 2011 Category: Microbiology Authors: Solé M, Pitart C, Roca I, Fàbrega A, Salvador P, Muñoz L, Oliveira I, Gascón J, Marco F, Vila J Tags: Antimicrob Agents Chemother Source Type: research

Dissemination of the New Delhi metallo-{beta}-lactamase-1 (NDM-1) among Enterobacteriaceae in a tertiary referral hospital in north IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - June 9, 2011 Category: Microbiology Authors: Seema, K., Ranjan Sen, M., Upadhyay, S., Bhattacharjee, A. Tags: Research letters Source Type: research

Canadian infected with bug made drug-resistant by NDM-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An elderly Ontario man has become the first patient in Canada to become infected by a bug that was made drug-resistant by NDM-1. (Source: CTV Health)
Source: CTV Health - May 30, 2011 Category: Consumer Health News Source Type: news

New Delhi metallo-beta-lactamase-1 enzyme acquired in CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An enzyme associated with extensive antibiotic resistance called New Delhi metallo-ß-lactamase-1 (NDM-1), endemic in India and Pakistan and spreading worldwide, has been found in two people in the Toronto area, one of whom acquired it in Canada, states a new case report. The report outlines challenges and approaches to managing and identifying this pathogen, which is highly resistant to treatment. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 30, 2011 Category: Science Source Type: news

Man acquires NDM-1 superbug while in CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An elderly Ontario man has become the first patient in Canada to acquire the NDM-1 superbug without leaving the country -- a discovery that suggests the bug is now spreading person-to-person within Canadian communities. (Source: CTV Health)
Source: CTV Health - May 30, 2011 Category: Consumer Health News Source Type: news

New Delhi Metallo-�-lactamase-1 Enzyme Acquired In CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An enzyme associated with extensive antibiotic resistance called New Delhi metallo-�-lactamase-1 (NDM-1), endemic in India and Pakistan and spreading worldwide, has been found in two people in the Toronto area, one of whom acquired it in Canada, states a case report in CMAJ (Canadian Medical Association Journal). The report outlines challenges and approaches to managing and identifying this pathogen, which is highly resistant to treatment. NDM-1 has spread because of worldwide travel, medical tourism and its ability to transfer between bacteria... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 30, 2011 Category: Consumer Health News Tags: Biology / Biochemistry Source Type: news

New Delhi Metallo-B-lactamase-1 Enzyme Acquired In CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An enzyme associated with extensive antibiotic resistance called New Delhi metallo-B-lactamase-1 (NDM-1), endemic in India and Pakistan and spreading worldwide, has been found in two people in the Toronto area, one of whom acquired it in Canada, states a case report in CMAJ (Canadian Medical Association Journal). The report outlines challenges and approaches to managing and identifying this pathogen, which is highly resistant to treatment. NDM-1 has spread because of worldwide travel, medical tourism and its ability to transfer between bacteria... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 30, 2011 Category: Consumer Health News Tags: Biology / Biochemistry Source Type: news

New Delhi metallo-beta-lactamase-1 enzyme acquired in CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Canadian Medical Association Journal) An enzyme associated with extensive antibiotic resistance called New Delhi metallo-ß-lactamase-1 (NDM-1), endemic in India and Pakistan and spreading worldwide, has been found in two people in the Toronto area, one of whom acquired it in Canada, states a case report in CMAJ. The report outlines challenges and approaches to managing and identifying this pathogen, which is highly resistant to treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 30, 2011 Category: Global & Universal Source Type: news

New Delhi metallo-ss-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the isolation NDM-1-producing organisms from two patients in Toronto, Ontario. To the best of our knowledge, this is the first report of an organism producing NDM-1 that was locally acquired in Canada. We also discuss the evidence that NDM-1 can affect bacterial species other than E. coli and K. pneumoniae, the limited options for treatment and the difficulty laboratories face in detecting organisms that produce NDM-1. PMID: 21624908 [PubMed - as supplied by publisher] (Source: cmaj)
Source: cmaj - May 29, 2011 Category: Journals (General) Authors: Kus JV, Tadros M, Simor A, Low DE, McGeer AJ, Willey BM, Larocque C, Pike K, Edwards IA, Dedier H, Melano R, Boyd DA, Mulvey MR, Louie L, Okeahialam C, Bayley M, Whitehead C, Richardson D, Carr L, Jinnah F, Poutanen SM Tags: CMAJ Source Type: research

Accumulation of carbapenemase-producing Gram-negative bacteria in a single patient linked to the acquisition of multiple carbapenemase producers and to the in vivo transfer of a plasmid encoding VIM-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Metallo-β-lactamases (MBLs) are class B enzymes that have emerged worldwide and that are mostly represented by VIM- and IMP-type enzymes as well as by New Delhi metallo-β-lactamase-1 (NDM-1). VIM-type MBLs are frequent in Mediterranean countries and the VIM-1 variant is now commonly found in Enterobacteriaceae . In vitro conjugation experiments have shown the transferability of plasmids carrying blaVIM genes but, to our knowledge, transfer by in vivo conjugation of carbapenemase determinants has never been demonstrated. Here we report on the in vivo transmissibility of VIM-1 through the study of a case of co-carriage of ...
Source: International Journal of Antimicrobial Agents - May 15, 2011 Category: Drugs & Pharmacology Authors: Laurence Drieux, Nadège Bourgeois-Nicolaos, Julie Cremniter, Christine Lawrence, Vincent Jarlier, Florence Doucet-Populaire, Wladimir Sougakoff Tags: Letters to the Editor Source Type: research

Emergence of NDM-1-producing Acinetobacter baumannii in ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We describe the emergence of A. baumannii producing NDM-1 in China. Systemic surveillance network should be established for monitoring these resistant bacteria. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 10, 2011 Category: Microbiology Authors: Chen, Y., Zhou, Z., Jiang, Y., Yu, Y. Tags: Original research Source Type: research

NDM-2 carbapenemase in Acinetobacter baumannii from EgyptEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This work further underlines the spread of NDM carbapenemases in A. baumannii, and the spread of the corresponding gene in the Middle East. It also describes the first variant of NDM-1. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 10, 2011 Category: Microbiology Authors: Kaase, M., Nordmann, P., Wichelhaus, T. A., Gatermann, S. G., Bonnin, R. A., Poirel, L. Tags: Original research Source Type: research

Sepsis in neonates due to imipenem-resistant Klebsiella pneumoniae producing NDM-1 in IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 10, 2011 Category: Microbiology Authors: Roy, S., Viswanathan, R., Singh, A. K., Das, P., Basu, S. Tags: Research letters Source Type: research

PolyMedix Defensin-Mimetic Antibiotic PMX-30063 Active Against NDM-1 Drug-Resistant BacteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PolyMedix, Inc. (OTC BB: PYMX), a biotechnology company focused on developing new therapeutic drugs to treat patients with acute infectious diseases and cardiovascular disorders, announced today that its lead defensin-mimetic antibiotic, PMX-30063, has shown activity in an in vitro laboratory test against the NDM-1 drug resistant strain of Klebsiella pneumonia. NDM-1 (New Delhi metallo-beta-lactamase-1) is an enzyme carried by some bacteria that are resistant to many antibiotics, including carbapenems... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 3, 2011 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Superbug - the so-called NDM-1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 21623026 [PubMed - in process] (Source: Indian J Med Res)
Source: Indian J Med Res - April 30, 2011 Category: Research Authors: Srivastava RK, Ichhpujani RI, Khare S, Rai A, Chauhan LS Tags: Indian J Med Res Source Type: research

[Articles] Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The presence of NDM-1 β-lactamase-producing bacteria in environmental samples in New Delhi has important implications for people living in the city who are reliant on public water and sanitation facilities. International surveillance of resistance, incorporating environmental sampling as well as examination of clinical isolates, needs to be established as a priority. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - April 28, 2011 Category: Infectious Diseases Authors: Timothy R Walsh, Janis Weeks, David M Livermore, Mark A Toleman Tags: Articles Source Type: research

[Review] Metallo-β-lactamases: a last frontier for β-lactams?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Metallo-β-lactamases are resistance determinants of increasing clinical relevance in Gram-negative bacteria. Because of their broad range, potent carbapenemase activity and resistance to inhibitors, these enzymes can confer resistance to almost all β-lactams. Since the 1990s, several metallo-β-lactamases encoded by mobile DNA have emerged in important Gram-negative pathogens (ie, in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii). Some of these enzymes (eg, VIM-1 and NDM-1) have been involved in the recent crisis resulting from the international dissemination of carbapenem-resistant Klebsiella p...
Source: The Lancet Infectious Diseases - April 28, 2011 Category: Infectious Diseases Authors: Giuseppe Cornaglia, Helen Giamarellou, Gian Maria Rossolini Tags: Review Source Type: research

[Comment] Environmental dissemination of NDM-1: time to act sensiblyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The production of β-lactamases in Gram-negative bacteria, including Enterobacteriaceae, is a serious bacterial resistance problem worldwide. The accumulation of antibiotic resistance in bacteria is, beyond any doubt, a practical demonstration of the darwinian rule of the survival of the fittest; thus, this resistance poses the serious problem of treatment failure. Recent studies have identified extended-spectrum β-lactamases in high proportions in enterobacteria from India; faced with this problem, the use of reserved antibiotics such as carbapenems has become necessary. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - April 28, 2011 Category: Infectious Diseases Authors: Mohd Shahid Tags: Comment Source Type: research

New Killer NDM-1 Superbugs Pose World ThreatEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Through mutation and horizontal gene transfer harmful bacteria once controlled through antibiotics are now virtually uncontrollable.  Years of excessive and indiscriminate use of antibiotics have contributed significantly to fostering the problem.  Existing antibiotics are now ineffective.  “The absence of new antibiotics has led to a growing reliance on older, more toxic drugs such as colistin, but resistance to these is already arising."  French and Chinese researchers both herald this as the "end of the antibiotic era".  The excessive use of antibiotics has been discussed and cr...
Source: ChiroACCESS: Tools for Better Patient Care - April 26, 2011 Category: Complementary Medicine Source Type: news

Real-time PCR assay allows detection of the New Delhi metallo-β-lactamase (NDM-1)-encoding gene in FranceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we report the development of a rapid real-time polymerase chain reaction (PCR) assay with TaqMan® probe to detect the New Delhi metallo-β-lactamase (NDM-1)-encoding gene directly from bacterial isolates. The specificity of the assay was verified in silico as well as with a large panel of 84 clinically relevant bacteria, including the Klebsiella pneumoniae NCTC 13443 NDM-1-positive reference strain. Using this assay retrospectively on a local series of 44 K. pneumoniae isolates from Marseille Hospitals (France), it was possible to detect and identify an NDM-1-producing K. pneumoniae strain isolated from bro...
Source: International Journal of Antimicrobial Agents - April 17, 2011 Category: Drugs & Pharmacology Authors: Seydina M. Diene, Nicolas Bruder, Didier Raoult, Jean-Marc Rolain Tags: Short communications Source Type: research

Drug-Resistant Bacteria, With NDM-1 Gene, Found In New Delhi Drinking WaterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NDM-1, a pathogenic bacteria which is resistant to most antibiotics, has been found in the public drinking water supply of India's capital, New Delhi, by scientists from Cardiff University, Wales. Among the disease-causing bacteria are those that cause dysentery and cholera. You can read about this in the medical journal The Lancet Infectious Disease. Action is urgently required by health authorities to fight the new strains and stem their spread around the world, the scientists said... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 7, 2011 Category: Consumer Health News Tags: MRSA / Drug Resistance Source Type: news

Antibiotic-resistant bacteria in Indian public water supplyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Disease-causing bacteria carrying the new genetic resistance to antibiotics, NDM-1, have been discovered in New Delhi's drinking water supply. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 7, 2011 Category: Science Source Type: news

Bacteria are winning the warEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The insidious spread of the latest form of antibiotic resistance is just one more sign that governments haven't grasped the gravity of the situation, writes Frank SwainIn what has surely become the most ritualised medical practice since the Hippocratic Oath, the World Health Organization took to the stage again today to warn that the misuse of antibiotics was threatening to render one of our most potent medicines useless. This comes a decade after an identical appeal from the organisation warned of a global crisis in the making.Health experts have been ringing the alarm over antimicrobial resistance for so long that it see...
Source: Guardian Unlimited Science - April 7, 2011 Category: Science Authors: Frank Swain Tags: Drugs Microbiology Medical research Science Antibiotics Society Health guardian.co.uk Blogposts Source Type: news

Antibiotic resistance: Bacteria are winning the war | Frank SwainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The insidious spread of the latest form of antibiotic resistance is just one more sign that governments haven't grasped the gravity of the situation, writes Frank SwainIn what has surely become the most ritualised medical practice since the Hippocratic Oath, the World Health Organization took to the stage again today to warn that the misuse of antibiotics was threatening to render one of our most potent medicines useless. This comes a decade after an identical appeal from the organisation warned of a global crisis in the making.Health experts have been ringing the alarm over antimicrobial resistance for so long that it see...
Source: Guardian Unlimited Science - April 7, 2011 Category: Science Authors: Frank Swain Tags: Drugs Microbiology Medical research Science Antibiotics Society Health guardian.co.uk Blogposts Source Type: news

WHO warns of drug resistant superbugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, researchers from Cardiff University in the UK, together with journalists from Channel 4, investigated how common NDM-1 producing bacteria are in community waste seepage (water pools in streets or rivulets) and tap water in urban New Delhi. They found the NDM-1 gene in two of the 50 drinking water samples, and 51 of 171 seepage samples. Bacteria that were positive for NDM-1 were grown from two drinking water samples and 12 seepage samples. Fourteen different types of bacteria were grown, including 11 bacteria in which NDM-1 had not previously been reported, such as Shigella boydii and Vibrio cholera. As a con...
Source: NHS News Feed - April 7, 2011 Category: Consumer Health News Tags: Medication QA articles Source Type: news

Discovery Of Antibiotic-Resistant Bacteria In Indian Public Water SupplyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Disease-causing bacteria carrying the new genetic resistance to antibiotics, NDM-1, have been discovered in New Delhi's drinking water supply. A Cardiff University-led team found new strains of resistant bacteria in the Indian capital, including species which cause cholera and dysentery. The findings are the first evidence of the environmental spread of NDM-1, which had previously only been found in hospitals. The scientists are calling for urgent action by health authorities worldwide to tackle the new strains and prevent their global spread... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 7, 2011 Category: Consumer Health News Tags: Water - Air Quality / Agriculture Source Type: news

Super Bug Researcher Calls For Global Action, AustraliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The World Health Organisation (WHO) must take a tougher stance on super bugs, according to a University of Queensland infectious diseases expert. Professor Tim Walsh, from UQ's Centre for Clinical Research, suggests that bacteria is more widespread than previously thought, with his research published in today's issue of The Lancet. The research indicates NDM-1 is present in New Delhi's drinking water and seepage, and thus is widely prevalent in the Indian environment... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 7, 2011 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Drug resistant superbug retains Delhi tagEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Naming the drug resistant superbug New Delhi Metallo Beta Lactamase-I (NDM-1 ) after India's capital city was 'a big mistake' admitted Lancet editor Dr Richard Horton. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 7, 2011 Category: Pharmaceuticals Source Type: news

NDM-1-Positive Multidrug-Resistant Bacteria In Public Water Supplies And Urban Effluent In New Delhi Suggesting NDM-1 Is Widespread In The EnvironmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The New Delhi metallo-beta-lactamase (NDM) 1 gene that enables bacteria to be highly resistant to almost all antibiotics has been found in bacteria in public water supplies in New Delhi, India, that are used by local residents for drinking, washing, and food preparation. Worryingly, the gene has spread to bacteria that cause cholera and dysentery. These findings, published Online First in The Lancet Infectious Diseases, suggest that NDM-1 is widespread in the environment and highlight the urgent need for global action to limit the worldwide spread of NDM-1 producing bacteria... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 6, 2011 Category: Consumer Health News Tags: Water - Air Quality / Agriculture Source Type: news

Superbug gene rife in Delhi water supplyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Global implications as NDM-1 gene is found to be widespread in water used for cooking, washing and drinkingA gene that causes a wide range of bacteria to become resistant to antibiotics has been found in the water supply in Delhi, with worrying implications for the rest of the globe.International travel and medical tourism have already brought the gene, known as NDM-1, to the UK. A team of scientists reported last year that they had found NDM-1 positive bacteria in a small number of patients who had visited India for kidney or bone marrow transplants, dialysis, pregnancy care or burns treatment, while others had undergone ...
Source: Guardian Unlimited Science - April 6, 2011 Category: Science Authors: Sarah Boseley Tags: India World news Water Environment Drug resistance Health Society Microbiology Genetics Medical research Drugs Science MRSA and superbugs The Guardian Source Type: news

Antibiotic resistance shows up in India's drinking waterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discovery of NDM-1 outside hospital environment raises alarm. (Source: news@nature.com)
Source: news@nature.com - April 6, 2011 Category: Consumer Health News Source Type: research

Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human healthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Lancet Infectious Diseases, Health Protection Agency (HPA), Lancet Area: News Research by the Health Protection Agency (HPA) and collaborators published early online in the Lancet Infectious Diseases in 2010 identified a new antibiotic resistance mechanism, due to the bacteria carrying a gene that produces an enzyme called New Delhi metallo-?-lactamase 1 (NDM-1), that confers resistance to multiple antibiotics, including the carbapenems.   In this current report in the Lancet Infectious Diseases, the researchers measured the prevalence of the NDM-1 gene in drinking water and seepage samples in New Delhi, ...
Source: NeLM - News - April 6, 2011 Category: Drugs & Pharmacology Source Type: news

Drinking Water in New Delhi Contaminated With NDM-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The New Delhi metallo-β-lactamase gene has been found in drinking and seepage water in New Delhi, according to a study published online April 7 in The Lancet Infectious Diseases. (Source: Modern Medicine)
Source: Modern Medicine - April 6, 2011 Category: Journals (General) Source Type: news

The perils of medical tourism: NDM-1-positive Escherichia coli causing febrile neutropenia in a medical tourist.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of NDM-1 infection in an immunocompromised foreign patient, and discuss its implications. PMID: 21552793 [PubMed - in process] (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - March 31, 2011 Category: Journals (General) Authors: Chan HL, Poon LM, Chan SG, Teo JW Tags: Singapore Med J Source Type: research