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This page shows you the latest news and research items in this category.

Long-Term Use of Ventricular Assist Device as a Bridge to Recovery in Acute Fulminant Myocarditis [CASE REPORTS]
We report the successful long-term use of a left ventricular assist device (Berlin EXCOR) as a bridge to recovery in a patient with fulminant parvovirus B19 myocarditis. The use of this device allowed time for myocardial recovery, avoiding the need for cardiac transplantation. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 28, 2013 Category: Cardiovascular & Thoracic Surgery Authors: George, C. L. S., Ameduri, R. K., Reed, R. C., Dummer, K. B., Overman, D. M., St. Louis, J. D. Tags: Mechanical Circulatory Assistance CASE REPORTS Source Type: research

Human parvovirus B19 infection in a renal transplant recipient: a case report
Conclusion: This case report suggests that the diagnostic process for parvovirus B19 in renal transplant recipients should include a polymerase chain reaction assay to detect B19-DNA, since specific serological tests may be unreliable given their impaired humoral responses. These results also indicate the importance of considering parvovirus B19 infection in the differential diagnosis of persistent anemia in transplanted patients. (Source: BMC Research Notes)
Source: BMC Research Notes - January 23, 2013 Category: Research Authors: Michelle AlvesSandra VilaçaMaria CarvalhoAna FernandesLuci DusseKarina Gomes Source Type: research

Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature.
Abstract Human parvovirus B19 is a well-known cause of severe conditions in patients with sickle cell disease, but the molecular mechanisms of the infection are insufficiently understood. The different clinical outcome of the acute parvovirus B19 infection in two pediatric patients with sickle cell disease has been examined. One of them developed life-threatening condition requiring emergency transfusions, while the other had asymptomatic infection, diagnosed occasionally. Both cases had high viral load and identical subgenotype, indicating that the viral molecular characteristics play a minimal role in the infecti...
Source: Braz J Infect Dis - January 2, 2013 Category: Infectious Diseases Authors: Slavov SN, Kashima S, Silva-Pinto AC, Amarilla AA, Aquino VH, Covas DT Tags: Braz J Infect Dis Source Type: research

IVIg treats red cell aplasia due to human parvovirus B19
NEW YORK (Reuters Health) - A single course of intravenous immunoglobulin (IVIg) can restore normal hemoglobin levels in most patients with pure red cell aplasia due to human parvovirus B19 infection (HPV-B19), new research shows. (Source: Modern Medicine)
Source: Modern Medicine - December 24, 2012 Category: Journals (General) Source Type: news

[Observations on human parvovirus B19 infection diagnosed in 2011].
Conclusion: The observations of this study may contribute to a better recognition of clinical symptoms of human parvovirus B19 infection. Orv. Hetil., 2012, 153, 1948-1957. PMID: 23204301 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - December 8, 2012 Category: Journals (General) Authors: Mihály I, Trethon A, Arányi Z, Lukács A, Kolozsi T, Prinz G, Marosi A, Lovas N, Dobner IS, Prinz G, Szalai Z, Pék T Tags: Orv Hetil Source Type: research

Common Variable Immunodeficiency Presenting With Persistent Parvovirus B19 Infection
Parvovirus B19 infection in healthy hosts is self-limited, but persistent infection has been described in patients with cellular immune defects. A 6-year-old boy presented with a 6-month history of weight loss and malaise and a 1-month history of fever and polyarticular arthritis. Parvovirus DNA was detected in plasma at 10 300 copies/mL. Levels of immunoglobulin (Ig)G, IgA, IgM, IgG-1, and IgG-2 were low, and antibody responses to vaccine antigens were impaired. HIV antibody and DNA polymerase chain reaction were negative, and the patient had normal immunophenotype, mitogen stimulation response, CD40 ligand and inducible ...
Source: PEDIATRICS - November 30, 2012 Category: Pediatrics Authors: Adams, S. T. M., Schmidt, K. M., Cost, K. M., Marshall, G. S. Tags: Case Report Source Type: research

Portable chemiluminescence multiplex biosensor for quantitative detection of three B19 DNA genotypes.
Abstract A miniaturized multiplex biosensor exploiting a microfluidic oligonucleotide array and chemiluminescence (CL) lensless imaging detection has been developed for parvovirus B19 genotyping. The portable device consists of a reaction chip, comprising a glass slide arrayed with three B19 genotype-specific probes and coupled with a polydimethylsiloxane microfluidic layer, and a charge-coupled device camera modified for lensless CL imaging. Immobilized probes were used in DNA hybridization reactions with biotin-labeled targets, and then hybrids were measured by means of an avidin-horseradish peroxidase (HRP) conj...
Source: Analytical and Bioanalytical Chemistry - November 28, 2012 Category: Chemistry Authors: Mirasoli M, Bonvicini F, Dolci LS, Zangheri M, Gallinella G, Roda A Tags: Anal Bioanal Chem Source Type: research

Detection of human parvovirus B19 in cancer patients using ELISA and real-time PCR
Conclusion: We found a high incidence of B19 infection among patients diagnosed with different types of haematological malignancies. We recommend that all cases of haematological disorders should be examined for specific antibodies and tested for the presence of B19 DNA in serum by PCR technique. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 24, 2012 Category: Microbiology Authors: SA Zaki Source Type: research

Neurologic consequence of a parvovirus B19 infection
We present the case of a patient with Guillain–Barre syndrome (GBS) associated with PVB 19. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - November 21, 2012 Category: Virology Authors: Gabriella Terhes, Márta Jenei, Edit Bereg, Sándor Túri, Judit Deák Tags: Full length articles Source Type: research

Investigation of human parvovirus B19 occurrence and genetic variability in different leukaemia entities
Abstract Human parvovirus B19V (B19V) has been associated with various haematological disorders, but data on its prevalence in leukaemia are scarce. In this cross‐sectional study, we investigated patients in Sao Paulo, Brazil with leukaemia to determine the molecular frequency of B19 variants and characterize the viral genetic variability by partial and complete sequencing of the coding of non‐structural protein 1 (NS1)/viral capsid proteins 1 and 2 (VP1/VP2). The presence of B19V infections was investigated by PCR amplification of the viral NS1 gene fragment and confirmed by sequencing analysis. The NS1/VP1/VP2 and pa...
Source: Clinical Microbiology and Infection - November 20, 2012 Category: Microbiology Authors: A. C. Costa, I. Bendit, A. C. S. Oliveira, E. G. Kallas, E. C. Sabino, S. S. Sanabani Tags: Original Article Source Type: research

Impact of chemiluminescent enzyme immunoassay screening for human parvovirus B19 antigen in Japanese blood donors.
CONCLUSION: CLEIA-B19V can detect all three genotypes of B19V (viral load >6.3 log IU/mL) and limit the viral load (<4 log IU/mL) in pooled plasma, and thus such screening has further reduced the risk of transfusion-transmitted B19V infection. These results show that CLEIA-B19V screening at the JRC Blood Centers can be an alternative approach to comply with recommendations regarding B19V in the United States and Europe. PMID: 23145866 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 12, 2012 Category: Hematology Authors: Sakata H, Matsubayashi K, Ihara H, Sato S, Kato T, Wakisaka A, Tadokoro K, Yu MY, Baylis SA, Ikeda H, Takamoto S Tags: Transfusion Source Type: research

Severe bone marrow failure associated with human parvovirus B19 infection in a case with no underlying disorder.
PMID: 23143653 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - November 10, 2012 Category: Hematology Authors: Kawakami C, Kono Y, Inoue A, Takitani K, Ikemoto T, Tamai H Tags: Int J Hematol Source Type: research

Polymicrogyria in a fetus with human parvovirus B19 infection: a case with radiologic–pathologic correlation
We report the prenatal magnetic resonance imaging (MRI) appearance of polymicrogyria with pathologic correlation in a fetus with congenital parvovirus B19 infection. Prenatal ultrasound revealed non‐immune hydrops, but detected no fetal brain abnormalities. A subsequent fetal MRI scan performed at 23 weeks' gestation demonstrated bilateral polymicrogyria, which was confirmed at autopsy. To our knowledge, prenatal diagnosis of polymicrogyria in association with congenital parvovirus B19 infection has not been previously described. This case provides further evidence for brain abnormalities resulting from congenital parvov...
Source: Ultrasound in Obstetrics and Gynecology - November 5, 2012 Category: Radiology Authors: J. Courtier, G. M. Schauer, J. T. Parer, A. C. Regenstein, P. W. Callen, O. A. Glenn Tags: Case Report Source Type: research

The effects of the 11 kDa protein and the putative X protein on the p6 promoter activity of Parvovirus B19 in Hela cells
Abstract Human parvovirus B19 (B19) is a small nonenveloped icosahedral virus with a single-stranded, linear 5.6 kb DNA genome. The p6 promoter, at map unit 6 of the viral genome, controls the expression of all B19 transcripts. Some previous reports revealed that this promoter is transactivated by NS1 protein. In an attempt to investigate the roles of other small viral proteins in the control of the p6 promoter activity, various truncated promoter/reporter constructs along with these nonstructural protein expression vectors were introduced into Hela cells. The results showed that the putative X protein ...
Source: Virus Genes - November 1, 2012 Category: Genetics & Stem Cells Tags: Virus Genes Source Type: research

Sweet’s syndrome and acute parvovirus B19 infection
(Source: International Journal of Dermatology)
Source: International Journal of Dermatology - November 1, 2012 Category: Dermatology Authors: Enrique Gutiérrez‐González, Adriana Álvarez‐Pérez, Dolores Sánchez‐Aguilar, Jaime Toribio Tags: Correspondence Source Type: research

A study on the association between parvovirus B19 infection, serum tumour necrosis factor and C-reactive protein levels among Nigerian patients with sickle cell anaemia.
Conclusion: We conclude that parvovirus B19 infection is common in this environment, and that serum TNF-α and CRP are predictors of clinical inflammatory episodes in infected SCA patients. PMID: 23192499 [PubMed - in process] (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - November 1, 2012 Category: Journals (General) Authors: Iwalokun BA, Iwalokun SO, Hodonu SO, Aina OA, Omilabu S Tags: Singapore Med J Source Type: research

Anterior ischemic optic neuropathy in patient with hereditary spherocytosis and coexisting angioid streaks.
Conclusions. This is the first report of AION in HE and coexisting angioid streaks. The infection by parvovirus itself might be involved in the development of AION. PMID: 23112036 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - October 26, 2012 Category: Opthalmology Authors: Sawada A, Oie S, Mochizuki K, Yamamoto T Tags: Eur J Ophthalmol Source Type: research

Parvovirus B19 Infection in the First Trimester of Pregnancy and Risk of Fetal Loss: A Population-based Case-Control Study
In conclusion, acute parvovirus B19 infection during the first trimester of pregnancy was associated with an increased risk of fetal loss. However, the impact on the overall burden of fetal losses appeared small even during epidemics. (Source: American Journal of Epidemiology)
Source: American Journal of Epidemiology - October 26, 2012 Category: Epidemiology Authors: Lassen, J., Jensen, A. K. V., Bager, P., Pedersen, C. B., Panum, I., Norgaard-Pedersen, B., Aaby, P., Wohlfahrt, J., Melbye, M. Tags: RESEARCH-ARTICLE Source Type: research

Parvovirus B19-induced pure red cell aplasia in a heart transplant recipient
(Source: Blood)
Source: Blood - October 25, 2012 Category: Hematology Authors: Fong, C. Y., Kaplan, Z. S. Tags: Blood Work, Red Cells, Iron, and Erythropoiesis Source Type: research

Viral myocarditis: from experimental models to molecular diagnosis in patients
Abstract Cardiotropic viruses have been implicated as major pathogenetic agents in acute and chronic forms of myocarditis. By the introduction of molecular tools, such as (RT-) polymerase chain reaction ((RT-) PCR) and in situ hybridization in the diagnosis of inflammatory heart disease, genomes of various RNA and DNA viruses comprising enteroviruses, adenoviruses, parvovirus B19 (B19V) and herpesviruses (EBV, HHV6, HCMV) were detected in endomyocardial biopsies of patients with myocarditis and dilated cardiomyopathy. Meanwhile, it is known that the outcome of a virus infection in the heart resulting in myoc...
Source: Heart Failure Reviews - October 15, 2012 Category: Cardiology Tags: Heart Failure Reviews Source Type: research

Acute isolated velopharyngeal insufficiency in children: case report and systematic review of the literature
Abstract Acute isolated velopharyngeal insufficiency (VPI) is a clinical entity mainly reported in children. We undertook a systematic review in order to better characterize its features. Following a Medline search (1960–2012), the authors reviewed and analyzed the cases of acute VPI in children; 36 cases were found. The most common presenting features were hypernasal speech (97 %), nasal reflux (73 %), and dysphagia (49 %). 73 % of the children were males and 27 % females, of 8.9 ± 2.5 years. In all the cases the VPI was unilateral. One quarter of the children had ...
Source: European Archives of Oto-Rhino-Laryngology - October 8, 2012 Category: ENT & OMF Tags: European Archives of Oto-Rhino-Laryngology Source Type: research

Investigation of Human Parvovirus B19 Occurrence and Genetic Variability in Different Leukemia Entities
Abstract Human parvovirus B19V (B19V) has been associated with various hematological disorders, but data on its prevalence in leukemia is scarce. In this cross‐sectional study, we investigated leukemic patients in Sao Paulo, Brazil to determine the molecular frequency of B19 variants and characterize the viral genetic variability by partial and complete coding NS1/VP1/VP2 sequencing. The presence of B19V infections was investigated by polymerase chain reaction (PCR) amplification of the viral NS1 gene fragment and confirmed by sequencing analysis. The NS1/VP1/VP2 and partially larger gene fragments of the NS1‐positive ...
Source: Clinical Microbiology and Infection - October 1, 2012 Category: Microbiology Authors: Antonio Charlys da Costa, Israel Bendit, Ana Carolina Soares Oliveira, Esper Georges Kallas, Ester Cerdeira Sabino, Sabri Saeed Sanabani Tags: Original Article Source Type: research

Parvovirus transmission by blood products – a cause for concern?
Summary The introduction of dual viral inactivation of clotting factor concentrates has practically eliminated infections by viruses associated with significant pathogenicity over the last 20 years. Despite this, theoretical concerns about transmission of infection have remained, as it is known that currently available viral inactivation methods are unable to eliminate parvovirus B19 or prions from these products. Recently, concern has been raised following the identification of the new parvoviruses, human parvovirus 4 (PARV4) and new genotypes of parvovirus B19, in blood products. Parvoviruses do not cause chronic pathog...
Source: British Journal of Haematology - October 1, 2012 Category: Hematology Authors: Päivi Norja, Riitta Lassila, Mike Makris Tags: Review Source Type: research

Emerging viral infections ‑ a potential threat for blood supply in the 21st century.
Abstract During the last 25 years the safety of blood products has improved dramatically with regard to infectious risk, notably to the threat represented by retroviruses (HIV and human T‑cell lymphotropic virus) and hepatitis B and C viruses. However, both residual and emergent viral infections are still responsible for contaminations in recipients of blood products. Along with other viruses (human herpesvirus‑8, human parvovirus B19, hepatitis A and E viruses, etc.), special attention has recently been paid to emerging arboviruses, such as West Nile virus in North America, and Dengue and Chikungunya viruses i...
Source: AIDS Reviews - October 1, 2012 Category: Infectious Diseases Authors: de Mendoza C, Altisent C, Aznar JA, Batlle J, Soriano V Tags: AIDS Rev Source Type: research

Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening.
CONCLUSION: These results are consistent with continued B19V transmission through plasma-derived factor concentrates. Effective viral inactivation and detection processes are needed to protect users of these products from infection with B19V or other new or emerging viruses. PMID: 22998193 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 24, 2012 Category: Hematology Authors: Soucie JM, De Staercke C, Monahan PE, Recht M, Chitlur MB, Gruppo R, Hooper WC, Kessler C, Kulkarni R, Manco-Johnson MJ, Powell J, Pyle M, Riske B, Sabio H, Trimble S, the US Hemophilia Treatment Center Network Tags: Transfusion Source Type: research

Wells syndrome in a child triggered by parvovirus B19 infection?
To the Editor: Eosinophilic cellulitis–Wells syndrome–was first described by Wells in 1971. It is a rare recurrent inflammatory dermatosis of uncertain pathogenesis. Wells reported the cases of 4 patients with characteristically cutaneous lesions, similar to bacterial cellulitis and histopathologically showing dermal eosinophilia with distinctive “flame figures.” In 1979 Wells and Smith introduced the term “eosinophilic cellulitis.” (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - September 17, 2012 Category: Dermatology Authors: Hugo Barreiros, Diogo Matos, Constança Furtado, Henriqueta Cunha, Elvira Bártolo Tags: JAAD Online Source Type: research

Absence of viruses in amniotic fluid of women with PPROM: a case series
The objective was to examine the amniotic fluid of women with PPROM for viral genomic content, and to correlate with the presence of bacterial infection and markers of intrauterine inflammation. A case series of 13 women with PPROM is presented. Amniocentesis was performed in each of these women. DNA/RNA isolated from amniotic fluid was tested using polymerase chain reaction (PCR) for the presence of herpes simplex virus (HSV)-1 and -2, adenovirus, adeno-associated virus-2 (AAV-2), cytomegalovirus (CMV), parvovirus B19, human papilloma viruses (HPV), and enteroviruses. Maternal and neonatal hospital course and laboratory i...
Source: Journal of Reproductive Immunology - September 17, 2012 Category: Allergy & Immunology Authors: Amber Naresh, Hyagriv Simhan Tags: Clinical Research Source Type: research

[Predictive factors for fetal tolerance to cordocentesis: A monocentric retrospective study.]
CONCLUSION: FBS remains a tricky procedure with a substantial risk of fetal loss or complications especially when performed on high-risk fœtuses. The length of the procedure should be shortened as much as possible (trained operator, postponed procedure when all favourable condition are not available). Fetal thrombocytopenia is a meaningful risk factor encouraging carefulness when exploring allo-immune fetal thrombocytopenia. PMID: 22981975 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique et Fertilite)
Source: Gynecologie, Obstetrique et Fertilite - September 13, 2012 Category: OBGYN Authors: De Jesus I, Simon E, Potin J, Arlicot C, Perrotin F Tags: Gynecol Obstet Fertil Source Type: research

The lack of routine surveillance of parvovirus B19 infection in pregnancy prevents an accurate understanding of this regular cause of fetal loss and the risks posed by occupational exposure.
Abstract In Europe fetal loss due to parvovirus B19 (B19V) is under-reported and a poorly addressed occupational risk to pregnant women. This is exemplified internationally, where it was unmentioned in the last 2 ECDC annual surveillance reports or its 2009 special report on infections in pregnancy. To assess this potential for under estimating B19V fetal loss in pregnancy, we undertook a systematic review of practice in Northern Ireland in the management and reporting of B19V infections over a 12 month period of heightened transmission, 1 of 6 observed in a span of 9 years. Pregnant and non-pregnant women presente...
Source: Journal of Medical Microbiology - September 13, 2012 Category: Microbiology Authors: Watt A, Brown M, Pathiraja M, Anbazhagan A, Coyle PV Tags: J Med Microbiol Source Type: research

Capsid protein expression and adeno-associated virus like particles assembly in Saccharomyces cerevisiae
Conclusions: Taken together, the results show for the first time that yeast can be used to assemble AAV capsid and, therefore, as a genetic system to identify novel cellular factors involved in AAV biology. (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - September 11, 2012 Category: Microbiology Authors: Ana BackovicTiziana CervelliAlessandra SalvettiLorena ZentilinMauro GiaccaAlvaro Galli Source Type: research

Development of chemiluminescent assays for the quantitative detection and imaging of 5-bromo-2'deoxyuridine-labeled DNA in parvovirus B19-infected cells.
Abstract Incorporation of exogenous analogues is a widely used method to evaluate DNA synthesis in cultured cells exposed to exogenous factors such as infectious agents. Herein, two new quantitative methodologies exploiting ultrasensitive chemiluminescence (CL) detection of 5-bromo-2'-deoxyuridine (BrdU) have been developed: a CL microscope imaging assay to evaluate BrdU labelling at single-cell level and a CL dot-blot assay to measure the amounts of DNA produced in the course of an in vitro infection of proliferating cells. The assays have been optimized on UT7/EpoS1 cells cultured in presence of different concent...
Source: Analytical and Bioanalytical Chemistry - September 8, 2012 Category: Chemistry Authors: Bonvicini F, Mirasoli M, Manaresi E, Gentilomi GA, Roda A, Gallinella G Tags: Anal Bioanal Chem Source Type: research

Detection of Five Rash-Associated Viruses Using Multiplex Real-Time PCR during 2006-2011.
Abstract Many viruses have been reported to be associated with rash development. Multiplex real-time PCR was used to investigate the presence of 5 viruses associated with rashes: measles virus (MV), rubella virus (RV), human parvovirus B19 (PVB19), human herpes virus 6 (HHV-6), and HHV-7. A total of 187 clinical specimens from 169 patients with erythema were collected between January 2006 and December 2011. Virus-positive specimens were as follows: MV (n = 23), PVB19 (n = 8), RV (n = 2), HHV-6 (n = 5), HHV-7 (n = 1), MV and PVB19 (n = 1), and HHV-6 and HHV-7 (n = 1). All of the MV-positive specimens were collected ...
Source: Japanese Journal of Infectious Diseases - September 1, 2012 Category: Infectious Diseases Authors: Kaida A, Kubo H, Sekiguchi J, Ohyama M, Goto K, Hase A, Iritani N Tags: Jpn J Infect Dis Source Type: research

Kikuchi-Fujimoto lymphadenitis: role of parvovirus B-19, Epstein-Barr virus, human herpesvirus 6, and human herpesvirus 8
Summary: Kikuchi-Fujimoto lymphadenitis is a self-limited disorder that typically presents in young females as painless cervical lymphadenopathy with fever, anemia, and leukopenia. The clinical manifestations and pathologic findings suggest a viral etiology, yet specific etiologic agents remain unknown. Although there are studies reporting positive associations between Kikuchi-Fujimoto lymphadenitis and parvovirus B19 and herpesviruses, other studies have failed to find an association with these viruses. To our knowledge, this current study is the largest study of Kikuchi-Fujimoto lymphadenitis in Western patients that use...
Source: Human Pathology - August 31, 2012 Category: Pathology Authors: Flavia Guimaraes Nunes Rosado, Yi-Wei Tang, Robert Paul Hasserjian, Colt M. McClain, Beverly Wang, Claudio A. Mosse Tags: Original Contributions Source Type: research

Anemia as a complication of parvovirus b19 infection in renal transplant recipients.
CONCLUSIONS. Active B19 infection was documented only in the anemic recipients and could be associated with the development of severe anemia after renal transplantation. This allows us to recommend concurrent screening for viral DNA in plasma and detection of anti-B19 IgM class antibodies. To find the association between B19 infection and the development of anemia, further investigations are necessary. PMID: 22885363 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - August 26, 2012 Category: Universities & Medical Training Authors: Capenko S, Kozireva S, Folkmane I, Bernarde K, Rozentāls R, Murovska M Tags: Medicina (Kaunas) Source Type: research

Intermittent rash, lymph node swelling, arthralgia and vaccinal viral detection after rubella immunization
A 26-year-old woman was immunized on August 2008 with the rubella/measles vaccine (MR, Serum Institute of India). She had been in good health previously, with no medical history of any rheumatologic affection. The patient had already been vaccinated against rubella two years before, in an immunization campaign that occurred in Brazilian the state of São Paulo, and had no adverse reactions. She inadvertently took the vaccine again in the national campaign in 2008. Five days after the most recent vaccination, she developed fever, retroauricular lymph node swelling, erythematous maculopapular rash on her trunk, back, abdomen...
Source: Journal of Clinical Virology - August 20, 2012 Category: Virology Authors: Felipe Augusto Souza Gualberto, Suely Pires Curti, Maria Isabel de Oliveira, Dewton Moraes-Vasconcelos, Cristina Adelaide Figueiredo Tags: VIROQAS Source Type: research

Idiopathic dilated cardiomyopathy and persistent viral infection: Lack of association in a controlled study using a quantitative assay
Conclusions: Our preliminary results disfavour the hypothesis that persistent myocardial viral infection might be a frequent cause of DCM. The detection of parvovirus B19 from both cardiomyopathy and non-cardiomyopathy patients supports the notion that this virus is widely spread in the population. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - August 16, 2012 Category: Cardiology Authors: Silvia Moimas, Serena Zacchigna, Marco Merlo, Alessandra Buiatti, Marco Anzini, Lorella Dreas, Alessandro Salvi, Andrea Di Lenarda, Mauro Giacca, Gianfranco Sinagra Tags: Original Articles Source Type: research

Molecular and phylogenetic analyses of human Parvovirus B19 isolated from Brazilian patients with sickle cell disease and β‐thalassemia major and healthy blood donors
This study investigates B19V infection in patients with sickle cell disease and β‐thalassemia using different experimental approaches. A total of 183 individuals (144 with sickle cell disease and 39 with β‐thalassemia major) and 100 healthy blood donors were examined for B19V using anti‐B19V IgG enzyme immunoassay, quantitative PCR, DNA sequencing, and phylogenetic analysis. Viremia was documented in 18.6% of patients and 1% of donors, and was generally characterized by low viral load (VL); however, acute infections were also observed. Anti‐B19V IgG was detected in 65.9% of patients with sickle cell disease and i...
Source: Journal of Medical Virology - August 15, 2012 Category: Virology Authors: Svetoslav Nanev Slavov, Simone Kashima Haddad, Ana Cristina Silva‐Pinto, Alberto Anastacio Amarilla, Helda Liz Alfonso, Victor Hugo Aquino, Dimas Tadeu Covas Tags: Research Article Source Type: research

Idiopathic dilated cardiomyopathy and persistent viral infection: Lack of association in a controlled study using a quantitative assay.
CONCLUSIONS: Our preliminary results disfavour the hypothesis that persistent myocardial viral infection might be a frequent cause of DCM. The detection of parvovirus B19 from both cardiomyopathy and non-cardiomyopathy patients supports the notion that this virus is widely spread in the population. PMID: 22901461 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - August 14, 2012 Category: Infectious Diseases Authors: Moimas S, Zacchigna S, Merlo M, Buiatti A, Anzini M, Dreas L, Salvi A, Di Lenarda A, Giacca M, Sinagra G Tags: Heart Lung Circ Source Type: research

Virus safety of plasma products using 20 nm instead of 15 nm filtration as virus removing step.
In this study, using optimised conditions, the virus removal capacity of 20 nm filters appears to be comparable or even better when compared to that of 15 nm filters. PMID: 22901944 [PubMed - as supplied by publisher] (Source: Biologicals : Journal of the International Association of Biological Standardization)
Source: Biologicals : Journal of the International Association of Biological Standardization - August 14, 2012 Category: Biotechnology Authors: Koenderman AH, Ter Hart HG, Prins-de Nijs IM, Bloem J, Stoffers S, Kempers A, Derksen GJ, Al B, Dekker L, Over J Tags: Biologicals Source Type: research

Parvovirus B19 Myocarditis Causes Significant Morbidity and Mortality in Children
Abstract Although parvovirus B19 (PVB19) currently is the most common cause of viral myocarditis, limited pediatric data exist. Whereas other viruses infect cardiomyocytes, PVB19 targets coronary endothelium, leading to myocardial ischemia and dysfunction. A retrospective review investigated patients with polymerase chain reaction (PCR)-verified PVB19 myocarditis at Texas Children’s Hospital and Arkansas Children’s Hospital (January 2005 to August 2008). The primary end points of the study were transplant-free survival and circulatory collapse (death, mechanical support, or transplantation). For the 19 p...
Source: Pediatric Cardiology - August 9, 2012 Category: Cardiology Tags: Pediatric Cardiology Source Type: research

Investigation of parvovirus B19 seroprevalence, endothelin-1 synthesis, and nitric oxide levels in the etiology of essential hypertension.
CONCLUSIONS: The role of HPV B19 in the etiology of essential HT was not shown in the present study. A larger sample may be needed for the investigation of these relations. PMID: 22468640 [PubMed - in process] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - August 7, 2012 Category: Cardiology Authors: Motor VK, Arica S, Motor S, Yilmaz N, Evirgen O, Inci M, Gokce C, Onlen Y Tags: Clin Exp Hypertens Source Type: research

Presence of the viral genome in the myocardial tissue of patients without clinical suspicion of myocarditis
Viral nucleic acids are detected in the myocardium of up to two thirds of patients with clinical suspicion of myocarditis, but also commonly persist in multiple tissues of healthy individuals. We read with great interest the recent article by Koepsell et al., who suggested parvovirus B19 (PV B19) located in mononuclear inflammatory cells to be a bystander in adult myocarditis. The authors found PV B19 in 26% of autopsy samples from myocarditis-negative hearts, which is in agreement with previously reported results in which 7.7% and 66% were detected in such samples. Moreover, PV B19 was detected in up to 85% of samples of ...
Source: Cardiovascular Pathology - August 3, 2012 Category: Cardiology Authors: Kateřina Linhartová, Petr Hubáček, David Zemánek, Daniela Kodetová, Miroslav Zajac, Marek Šetina, Josef Veselka Tags: Correspondence Source Type: research

Evaluation of two, commercial, multi‐dye, nucleic acid amplification technology tests, for HBV/HCV/HIV‐1/HIV‐2 and B19V/HAV, for screening blood and plasma for further manufacture
Conclusion These multiplex and multi‐dye blood screening assays represent a flexible NAT screening system for mini‐pools between 6 and 96 samples per pool and fulfil all requirements of the European Pharmacopoeia for HCV and B19V testing of plasma for fractionation. The inclusion of a new multi‐dye technology means discriminatory assays are no longer required for either test thus improving workflow, turn‐around time and minimize the risk of obtaining a reactive result for which the virus cannot be identified. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 1, 2012 Category: Hematology Authors: M. M. Müller, M. I. G. Fraile, M. K. Hourfar, L. B. Peris, W. Sireis, M. G. Rubin, E. M. López, G. T. Rodriguez, E. Seifried, J. Saldanha, M. Schmidt Tags: ORIGINAL PAPER Source Type: research

[Seroprevalence of antibodies against infectious pathogens relevant to pregnancy among healthcare workers].
Abstract Healthcare workers (HCWs) are exposed to infectious diseases throughout the course of their work. The concerns of pregnant HCWs are considerable because certain otherwise mild infections may affect fetal development. We studied 424 pregnant HCWs at the University Hospital Frankfurt between March 2007 and July 2011. Serological tests were carried out for varicella zoster virus (VZV), measles, mumps, rubella (MMR), cytomegalovirus (CMV) and parvovirus B19. Our overall seroprevalence data with regard to VZV, MMR, CMV and parvovirus B 19 corresponded to the general population. However, physicians demonstrated ...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - August 1, 2012 Category: Global & Universal Authors: Wicker S, Friedrichs I, Rabenau HF Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research

How many times can parvovirus B19‐related anemia recur in solid organ transplant recipients?
In this report, we describe in detail the cases of 2 kidney recipients with PB19 infection. They experienced, respectively, 9 and 7 PB19‐related anemia recurrences. Immunosuppression level was decreased and IVIg were administered at each recurrence followed by a transitory normalization of hemoglobin level and a decrease of serum PB19 viral load. Episodes were separated by several months. These patients raise an original therapeutic management question about a frequent viral infection in SOT recipients. One patient is currently receiving IVIg every 3 months as a secondary prophylaxis without recurrence to date. These 2 ...
Source: Transplant Infectious Disease - August 1, 2012 Category: Transplant Surgery Authors: C. Gosset, D. Viglietti, K. Hue, C. Antoine, D. Glotz, E. Pillebout Tags: Case report Source Type: research

miRNA and tropism of human parvovirus B19.
Abstract Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation of these results is an inhibition of translation in nonpermissive cells by human miRNAs. We bring support to our hypothesis and propose detailed experimental procedure to test it. PMID: 22902951 [PubMed -...
Source: Computational Biology and Chemistry - July 31, 2012 Category: Bioinformatics Authors: Berillo O, Khailenko V, Ivashchenko A, Perlmuter-Shoshany L, Bolshoy A Tags: Comput Biol Chem Source Type: research

A preterm infant with anaemia and left leg mild hemihypertrophy
AbstractA 29 years‐old primiparous woman presented with spontaneous pregnancy.Ultrasound performed at 29 weeks of gestation showed a thickened placenta with hypoechoic areas, umbilical vein dilatation and 2 hepatic masses in the fetus. Maternal infections for toxoplasma, rubella, syphilis, herpes, cytomegalovirus and parvovirus B19 were ruled out. At 31 weeks of gestation the mother developed preeclampsia and an increased peak systolic velocity of middle cerebral artery suggested fetal anaemia.© 2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica (Source: Acta Paediatrica)
Source: Acta Paediatrica - July 30, 2012 Category: Pediatrics Authors: Jose María Lloreda‐García, Jose Luis Leante Castellanos, Joaquin Susmozas Sánchez Source Type: research

Proliferative glomerulonephritis with monoclonal immunoglobulin G3κ deposits in association with parvovirus B19 infection
Summary: Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is a recently described disease entity, characterized by nonorganized electron-dense deposits in glomeruli and immunofluorescence findings indicating monoclonal immunoglobulin G deposits. The pathogenesis of many cases of proliferative glomerulonephritis with monoclonal immunoglobulin G deposits remains unknown. We herein report 2 patients with parvovirus B19 infection who developed acute nephritic syndrome with hypocomplementemia (patient 1) or persistent proteinuria and congestive heart failure (patient 2); however, neither patient had de...
Source: Human Pathology - July 23, 2012 Category: Pathology Authors: Emiko Fujita, Akira Shimizu, Tomohiro Kaneko, Yukinari Masuda, Chikara Ishihara, Akiko Mii, Seiichiro Higo, Yusuke Kajimoto, Go Kanzaki, Shinya Nagasaka, Yasuhiko Iino, Yasuo Katayama, Yuh Fukuda Tags: Original Contributions Source Type: research

Parvovirus B19 with a scarlatiniform/rubelliform rash and small joint arthritis mimicking rubella in an adult
Rubella, in adults, is a difficult diagnosis if posterior auricular/occipital adenopathy is not present. Rubella should be considered if rash accompanied by small joint arthralgias/arthritis. (Source: Travel Medicine and Infectious Disease)
Source: Travel Medicine and Infectious Disease - July 16, 2012 Category: Infectious Diseases Authors: Burke A. Cunha, Joseph Chandrankunnel Tags: Correspondence Source Type: research

PVB19-associated purpuric–petechial eruption with Henoch Schönlein-like distribution
We report the case of an afebrile patient with atypical presentation of papular–purpuric eruption entirely compatible with the newly described PAPPE. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 12, 2012 Category: Virology Authors: Elena Conde-Montero, Minia Campos-Domínguez, María Dolores Mendoza-Cembranos, Ricardo Suárez-Fernández Tags: Letters to the Editor Source Type: research