Erythema Infectiosum
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Pharmacological Activation of Guanine Nucleotide Exchange Factors for the Small GTPase Rap1 Recruits High-Affinity β1 Integrins as Coreceptors for Parvovirus B19: Improved Ex Vivo Gene Transfer to Human Erythroid Progenitor Cells
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Human Gene Therapy , Vol. 0, No. 0. (Source: Human Gene Therapy)
Source: Human Gene Therapy - November 16, 2009 Category: Genetics & Stem Cells Tags: article Source Type: journals
What Is Erythema Infectiosum? What Is Slapped Cheek Syndrome?
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Eythema infectiosum is also known as parvovirus infection, slapped cheek disease, or fifth disease. It is a disease caused by the parvovirus B19 and includes such symptoms as low-grade fever, tiredness, rash on the cheeks (hence "slapped cheek"), and also a rash all over the person's body. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 4, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
Prevalence of Parvovirus B19 and Human Bocavirus DNA in the Heart of Patients with no Evidence of Dilated Cardiomyopathy or Myocarditis
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Conclusions. Our data suggest that B19V but not HBoV demonstrates a lifelong persistence in the heart. The detection of B19V DNA in heart tissue showed no correlation with clinical symptoms. We strongly recommend that serological testing become a standardized procedure for future studies, to obtain representative data concerning the prevalence of B19V in the heart. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - October 28, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Intrahepatic long-term persistence of parvovirus B19 and its role in chronic viral hepatitis
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This study aimed to investigate the impact of B19V infection in European patients with viral hepatitis. B19V DNA was detected in 1/91 and 0/50 serum samples from patients with chronic hepatitis C and B, respectively. In contrast, B19V DNA was amplified frequently from explanted end-stage liver tissues (37/50, 74%) and from routine biopsy samples (14/32, 44%) (P < 0.05). However, there was no significant difference in B19V copy number per cell between these two groups. B19V-specific CD4+ T-cell responses to two dominant MHC-class-restricted epitopes were detected in a similar frequency in healthy anti-B19V-positive individu...
Source: Journal of Medical Virology - October 25, 2009 Category: Virology Authors: Chun Wang, Albert Heim, Verena Schlaphoff, P.V. Suneetha, Kerstin A. Stegmann, Hong Jiang, Martin Krueger, Paraskevi Fytili, Thomas Schulz, Markus Cornberg, Reinhard Kandolf, Michael P. Manns, C. Thomas Bock, Heiner Wedemeyer Tags: Research Article Source Type: journals
A linked donor-recipient study to evaluate parvovirus B19 transmission by blood component transfusion
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Parvovirus B19V infection can be a serious infection for hematology patients with underlying hemolysis or compromised erythropoiesis syndromes. Although case reports of B19V transmission by blood component transfusion (as contrasted to manufactured plasma derivatives) are rare, no studies have systematically determined a rate of transmission to recipients transfused with B19V DNA–positive components. We used a linked donor and recipient repository and a sensitive, quantitative B19V DNA polymerase chain reaction (PCR) assay to assess such transmission in B19V-susceptible (ie, anti-B19V immunoglobulin G [IgG] negative)...
Source: Blood - October 22, 2009 Category: Hematology Authors: Kleinman, S. H., Glynn, S. A., Lee, T.-H., Tobler, L. H., Schlumpf, K. S., Todd, D. S., Qiao, H., Yu, M.-y. W., Busch, M. P., for the National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study-II (NHLBI REDS-II) Tags: Transfusion Medicine, Free Research Articles, Red Cells, Iron, and Erythropoiesis Source Type: journals
Parvovirus B19-induced Thrombocytopenia and Anemia in a Child with Fatal Fulminant Hepatic Failure Coinfected with Hepatitis A and E Viruses
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A 5-year-old male, drowsy, jaundiced child presented with fulminant hepatitis and had HAV and HEV infection. He had hepatic encephalopathy grade 1, fever, pallor, hypotension, crepitations in his right lung base and hepatosplenomegaly with dyspnoea. He had highly raised liver enzymes and hypoalbuminemia (2.8 g/dl) but anemia (hemoglobin of 7.7 g/dl and 5.7 g/dl 2 days later), reticulocytopenia and severe thrombocytopenia (44 x 109/l) were unexplained. Parvovirus B19-specific IgM antibodies and B19 DNA were found in the serum of the child. Chest X-ray showed pleural effusion and bronchopneumonia, while blood culture isolate...
Source: Journal of Tropical Pediatrics - October 12, 2009 Category: Tropical Medicine Authors: Kishore, J., Sen, M. Tags: Case Reports Source Type: journals
Information on 5th disease (slapped cheek disease) for parents
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Information and photos of 5th disease, also known as slapped cheek disease, erythema infectiosum and parvovirus infection. (Source: Blog from a Pediatrician)
Source: Blog from a Pediatrician - October 6, 2009 Category: Pediatrics Source Type: consumer
Detection of Viral DNA in Kidney Graft Preservation and Washing Solutions Is Predictive of Posttransplant Infections in Pediatric Recipients
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Conclusions. Molecular testing of donor grafts for viruses that infect circulating and resident cells in the graft—such as B19 in the kidney—could be useful (in association with donor/recipient serostatus) for identifying recipients at high risk for posttransplant infections. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 5, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Management and Outcome of Pregnancies with Parvovirus B19 Infection over Seven Years in a Tertiary Fetal Medicine Unit
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Fetal Diagn Ther 2009;25:373-378 (DOI:10.1159/000236149) (Source: Karger Publishers)
Source: Karger Publishers - September 29, 2009 Category: Cancer & Oncology Source Type: journals
When Does the Rash of Roseola Occur?
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Discussion
Rashes, particularly ones caused by viruses, are common presenting problems. In his first edition of Pediatrics, Dr. Rotch spent 72 pages describing infectious exanthemata. The cause of the exanthemata was unknown at the time, and thankfully many of those that he wrote of have been eradicated (smallpox), have effective vaccines to prevent (measles, rubella, varicella) or effective antibiotics for treatment (streptococcus).
Dr. Rotch ends his extensive treatise with a table describing “the chief points of differential diagnosis in the exanthemata.” This is what was state-of-the-art in 1896 with his s...
Source: PediatricEducation.org - September 28, 2009 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: info
Maternal human parvovirus B19 infection and the risk of fetal death and low birthweight: a case-control study within 35 940 pregnant women.
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CONCLUSION: Maternal parvovirus B19 infection was not associated with fetal death in our study. Very few cases of fetal death may be attributed to maternal parvovirus B19 infection.
PMID: 19769750 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - September 24, 2009 Category: OBGYN Authors: Sarfraz AA, Samuelsen SO, Bruu AL, Jenum PA, Eskild A Tags: BJOG Source Type: journals
Prevalence of persistent and latent viruses in untreated patients infected with HIV-1 from Ghana, West Africa
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This study was conducted to determine the prevalence of persistent viruses in individuals with untreated HIV-1 infection and uninfected blood donors. Paired plasma and cellular samples from HIV-negative blood donors, asymptomatic HIV and symptomatic/AIDS cohorts were screened by multiplex PCR then qPCR for parvovirus B19 (B19V), hepatitis B virus (HBV), GB virus-C (GBV-C), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus-8 (HHV-8) and varicella-zoster virus (VZV). IgG antibodies specific to each target virus were tested to determine exposure rates. No evidence of viraemia was found for B19V and VZV in any...
Source: Journal of Medical Virology - September 21, 2009 Category: Virology Authors: Lara Isobel Compston, Chengyao Li, Francis Sarkodie, Shirley Owusu-Ofori, Ohene Opare-Sem, Jean-Pierre Allain Tags: Research Article Source Type: journals
A prospective study of multiple donor exposure blood recipients: surveillance value and limitations for hemovigilance.
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CONCLUSION: The risk of transfusion-associated B19 infection appears to be low but no conclusion of transfusion transmission can be made for Cp. The approach piloted through this study offers added value beyond the current hemovigilance strategy in the United States.
PMID: 19778336 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 21, 2009 Category: Hematology Authors: Zou S, Wu Y, Cable R, Dorsey K, Tang Y, Hapip CA, Melmed R, Trouern-Trend J, Carrano D, Champion M, Fujii K, Fang C, Dodd R Tags: Transfusion Source Type: journals
[Seroprevalence of human parvovirus B19 in ambulatory population of Cantabria, northern Spain.]
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PMID: 19783492 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - September 21, 2009 Category: Pediatrics Authors: Ruiz de Alegría Puig C, Balbás García de Bustos R, Herrera González MC, Martínez-Bernal MA Tags: An Pediatr (Barc) Source Type: journals
Epstein-Barr virus and parvovirus B19 coinfection in a Crohn's disease patient under azathioprine
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No abstract. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - September 15, 2009 Category: Gastroenterology Authors: Teresa Moreira, Paula Lago, Marta Salgado, Rita Pimentel Source Type: journals
Clinical and epidemiological aspects of parvovirus B19 infections in Ireland, January 1996-June 2008.
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Parvovirus B19 infection may be mistakenly reported as measles or rubella if laboratory testing is not performed. As Europe is seeking to eliminate measles, an accurate diagnosis of fever/rash illnesses is needed. The main purpose of this study was to describe the epidemiological pattern of parvovirus B19, a common cause of rash, in Ireland between January 1996 and June 2008, using times series analysis of laboratory diagnostic data from the National Virus Reference Laboratory. Most diagnostic tests for presumptive parvovirus B19 infection were done in children under the age of five years and in women of child-bearing ...
Source: Euro Surveill - September 11, 2009 Category: Infectious Diseases Authors: Nicolay N, Cotter S Tags: Euro Surveill Source Type: journals
Azathioprine: Parvovirus B19 infection leading to leucopenia: case report
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(Source: Reactions)
Source: Reactions - September 7, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals
[Risks and side effects of blood transfusion.]
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This article addresses the incidence, clinical picture, and etiology of adverse effects of transfusion. It also reports on current knowledge concerning transfusion-associated acute lung injury, which has gained much attention in the last few years. Besides hepatitis and human immunodeficiency viruses, cytomegalovirus, parvovirus B19, prion transmission, and the risk of variant Creutzfeld-Jakob disease are also discussed.
PMID: 19756492 [PubMed - as supplied by publisher] (Source: Der Orthopade)
Source: Der Orthopade - September 5, 2009 Category: Orthopaedics Authors: Fölsch B, Cassens U Tags: Orthopade Source Type: journals
Seroepidemiological study of human parvovirus B19 among human immunodeficiency virus-infected patients in a medium-sized city in Rio de Janeiro, Brazil.
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Parvovirus B19 (B-19) may cause chronic anaemia in immunosuppressed patients, including those infected with human immunodeficiency virus (HIV). We studied single serum samples from 261 consecutive HIV-infected patients using an enzyme immunoassay to detect IgG antibodies to B-19. The seroprevalence of B-19-IgG was 62.8%. The differences in seroprevalence across gender, age, educational categories, year of collection of the serum samples, clinical and antiretroviral therapy characteristics, CD4+ count, CD4+ and CD8+ percentage and CD4+/CD8+ ratios were neither substantial nor statistically significant. There was a non-s...
Source: Memorias do Instituto Oswaldo Cruz - September 1, 2009 Category: Infectious Diseases Authors: Azevedo KM, Setúbal S, Camacho LA, Velarde LG, Oliveira SA Tags: Mem Inst Oswaldo Cruz Source Type: journals
Relationship among epidemiological parameters of six childhood infections in a non-immunized Brazilian community.
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Epidemiological parameters, such as age-dependent force of infection and average age at infection (<IMG SRC='../img/13s1.gif' WIDTH=9 HEIGHT=12>) were estimated for rubella, varicella, rotavirus A, respiratory syncytial virus, hepatitis A and parvovirus B19 infections for a non-immunized Brazilian community, using the same sera samples. The for the aforementioned diseases were 8.45 years (yr) [95% CI: (7.23, 9.48) yr], 3.90 yr [95% CI: (3.51, 4.28) yr], 1.03 yr [95% CI: (0.96, 1.09) yr], 1.58 yr [95% CI: (1.39, 1.79) yr], 7.17 yr [95% CI: (6.48, 7.80) yr] and 7.43 yr [95% CI: (5.68, 9.59) yr], respectively. The d...
Source: Memorias do Instituto Oswaldo Cruz - September 1, 2009 Category: Infectious Diseases Authors: Amaku M, Azevedo RS, Castro RM, Massad E, Coutinho FA Tags: Mem Inst Oswaldo Cruz Source Type: journals
Facial rash in a pregnant woman
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Case presentation A 24-year-old pregnant woman presented to her General Practitioner at 20 weeks gestation. She gave a 5-day history of vague symptoms, consisting principally of epigastric pain and a mild cough. A community pharmacist had noted a facial rash, raised the concern of ‘slapped cheek syndrome’ and advised her to seek medical attention. She was otherwise well and the pregnancy had been uneventful. Rubella IgG had been detected on routine antenatal screening at 12 weeks gestation, and an ultrasound scan at that point had been unremarkable. A current serum sample and the booking serum sample were submitted fo...
Source: Journal of Clinical Virology - August 31, 2009 Category: Virology Authors: Sheila Waugh, Kevin E. Brown Tags: Virology Question and Answer Scheme Source Type: journals
Rashes and Fever in Children: Sorting Out the Potentially Dangerous, Part 3
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Children who present with rash and fever can be divided into 3 groups: those with features of serious illness who require immediate intervention, those with clearly recognizable viral syndromes, and those with early or undifferentiated rash. The morphology of lesions among children with symptoms of serious illness offers clues to the underlying cause. Fever accompanied by pharyngitis and a “sandpaper” rash that begins around the neck suggests scarlet fever. In most children with fever and rash who have clearly recognizable viral illnesses, such as measles or erythema infectiosum, diagnosis is clinical and therapy inclu...
Source: Consultant Live - August 28, 2009 Category: Primary Care Source Type: info
Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation.
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We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough ...
Source: World Journal of Gastroenterology : WJG - August 27, 2009 Category: Gastroenterology Authors: Krygier DS, Steinbrecher UP, Petric M, Erb SR, Chung SW, Scudamore CH, Buczkowski AK, Yoshida EM Tags: World J Gastroenterol Source Type: journals
Phylogenetic analysis of a near-full-length sequence of an erythrovirus genotype 3 strain isolated in Brazil
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Abstract Human parvovirus B19 is the only member of the genus Erythrovirus that causes human disease. Recent findings of several strains with considerable sequence divergence from B19 have suggested
a new classification for parvovirus genotypes as 1 (B19), 2 (A-6 and LaLi) and 3 (V9). In their overall DNA sequence, the
three genotypes differ by ~10%. Here, we report the isolation of a genotype-3-related strain named BR543 during a prospective
study conducted in Sao Paulo, Brazil. Analysis of the nearly full-length genome sequence of BR543 indicates that this B19
variant sequence clusters with Gh2768, a strai...
Source: Archives of Virology - August 22, 2009 Category: Virology Tags: Archives of Virology Source Type: journals
High Frequencies of Exposure to the Novel Human Parvovirus PARV4 in Hemophiliacs and Injection Drug Users, as Detected by a Serological Assay for PARV4 Antibodies
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Conclusions. The present study provides convincing evidence that PARV4 is primarily transmitted parenterally. Evidence for widespread infection of hemophiliacs treated with nonvirally inactivated clotting factor creates fresh safety concerns for plasma‐derived blood products, particularly because parvoviruses are relatively resistant to virus inactivation. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - August 19, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Influence of amplicon size on the polymerase chain reaction of Parvovirus B19 genome in formalin-fixed specimens
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In conclusion, although PCR is highly specific and sensitive in fresh or ideally fixed material, a careful standardization of PCR assays is necessary when using formalin fixed paraffin-embedded tissues by applying primers that require smaller DNA fragments for amplification.A reação em cadeia da polimerase (PCR) tem fornecido diagnóstico de material de arquivo, mas alguns métodos de fixação, tais como formalina, provocam danos ao DNA e subsequentemente afetam sua análise, particularmente tecidos embebidos em parafina. A PCR é conhecida pela sua alta especificidade e sensibilidade, embora algumas dificuldades ocorra...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - August 14, 2009 Category: Pathology Source Type: journals
Chronic parvovirus B19 infection leading to red cell aplasia following treatment of Hodgkin lymphoma
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(Source: British Journal of Haematology)
Source: British Journal of Haematology - August 12, 2009 Category: Hematology Authors: Sarah Poplar, Sarah Allford, Nicholas Rooney Source Type: journals
Fulminant parvovirus B19-associated pancarditis with haemophagocytic lympho-histiocytosis in an immunocompetent adult
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We describe autopsy findings of a patient who had a lethal myocarditis with haemophagocytic lympho-histiocytosis in a course of systemic PVB19 infection. The present case illustrates the unusually severe and rapid course of PVB19 myocarditis with associated haemophagocytic lympho-histiocytosis leading to death. (Source: APMIS)
Source: APMIS - August 12, 2009 Category: Research Authors: AMANJIT BAL, BAIJAYANTIMALA MISHRA, NAVNEET SINGH, ASHIM DAS, SK JINDAL Source Type: journals
Acute infection with parvovirus B19 in early pregnancy.
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PMID: 19644946 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - July 29, 2009 Category: Radiology Authors: Bizjak G, Blondin D, Hammer R, Kozlowski P, Siegmann HJ, Stressig R Tags: Ultrasound Obstet Gynecol Source Type: journals
Hyperthyroidism associated with human parvovirus B19 infection
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(Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - July 28, 2009 Category: Dermatology Authors: M. Seishima, Y. Shibuya, S. Suzuki Source Type: journals
Guidance for Industry: Nucleic Acid Testing (NAT) to Reduce the Possible Risk of Parvovirus B19 Transmission by Plasma-Derived Products
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Recommendations for performing nucleic acid testing (NAT) for human parvovirus B19 as an in-process test for Source Plasma and recovered plasma used in the further manufacturing of plasma-derived products. (Source: What's New at CBER)
Source: What's New at CBER - July 27, 2009 Category: Biomedical Science Source Type: organizations
Detection of parvovirus B19 in the lower respiratory tract
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Conclusions: Parvovirus B19 may be detected at low frequency in BAL specimens from patients with different pathological backgrounds. This finding could be due to chronic infection with virus persistence in the lower respiratory tract, also in the absence of symptoms unequivocally attributable to B19. The high rate of mortality warrants the need for further studies to evaluate the opportunity to consider parvovirus B19 in the diagnostic work-up of lower respiratory tract infections. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 26, 2009 Category: Virology Authors: Cristina Costa, Maria Elena Terlizzi, Paolo Solidoro, Daniela Libertucci, Massimiliano Bergallo, Rossana Cavallo Tags: Full length articles Source Type: journals
Persistent Adeno-associated Virus 2 and Parvovirus B19 Sequences in Post-mortem Human Cerebellum.
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We previously reported in a large cohort (N = 104) of post-mortem tissues the detection of both the non-pathogenic adeno-associated virus (AAV2) in approximately 13% and the pathogenic human parvovirus B19 (B19) in approximately 42% of human brains, particularly the dorsolateral prefrontal cortex. Multiple animal parvoviruses target the developing cerebellum (CBLM) resulting in hypoplasia and ataxia, but very little is known about the human parvoviruses and their ability to infect or cause disease in the CBLM. We have now confirmed in the above cohort the presence of AAV2 and B19 sequences in the CBLM. Our results show...
Source: Cerebellum - July 7, 2009 Category: Neuroscience Authors: Grant JK, Yin NC, Zaytoun AM, Waseem H, Hobbs JA Tags: Cerebellum Source Type: journals
Middle cerebral artery peak systolic velocity and ductus venosus velocity in the investigation of nonimmune hydrops
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This study was performed to investigate the cause of nonimmune hydrops fetalis by measuring the peak systolic velocity (PSV) in the middle cerebral artery (MCA) and velocity waveforms of the ductus venosus (DV) with Doppler.This cross-sectional study was done on 19 pregnancies referred to three university teaching hospitals for further investigation of nonimmune hydrops fetalis in 2007 and 2008. The MCA-PSV and DV velocity waveforms were recorded in all fetuses. Anemia was investigated in cases with MCA-PSV values greater than 1.50 MoM (multiple of the median). Cardiovascular causes and chromosomal abnormalities were inves...
Source: Journal of Clinical Ultrasound - July 6, 2009 Category: Radiology Authors: Sedigheh Borna, Fatemeh Mirzaie, Sedigheh Hanthoush-Zadeh, Soghra Khazardoost, Fatemeh Rahimi-Sharbaf Source Type: journals
Pancreas allograft thrombosis following intravenous immunoglobulin administration to treat parvovirus B19 infection
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A.S.R. Muthusamy, A.C. Vaidya, S. Sinha, S.F. Atabani, T. Haque, G. Jones, J. Cunningham, P.J. Friend. Pancreas allograft thrombosis following intravenous immunoglobulin administration to treat parvovirus B19 infection.Transpl Infect Dis 2009. All rights reserved Pancreas graft thrombosis is one of the commonest non-immunological causes for early graft loss after transplantation. This case report describes a patient who developed graft thrombosis after intravenous immunoglobulin administration to treat acute parvovirus B19 infection. The potential role of hypercoagulability in graft thrombosis and the implications for immu...
Source: Transplant Infectious Disease - July 4, 2009 Category: Transplant Surgery Authors: A.S.R. Muthusamy, A.C. Vaidya, S. Sinha, S.F. Atabani, T. Haque, G. Jones, J. Cunningham, P.J. Friend Source Type: journals
Performance of the Epstein-Barr Virus (EBV) and Herpes Simplex Immunoglobulin M (IgM) Assays Carried out on the Liaison Platform with Sera from Patients Displaying Acute Parvovirus B19 Infection.
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Acute parvovirus B19 infection has been reported to cause frequently false-positive results in the Epstein-Barr (EBV) and herpes simplex virus (HSV) IgM assays from DiaSorin performed on the Liaison platform. We tested 65 sera from patients with presumptive or conclusive diagnosis of acute parvovirus B19 infection in both assays and found no false-positive results in the EBV IgM test, and 10.4 % of nonspecific reactivities in the HSV IgM assay. Our data support the specificity of both assays in this clinical setting.
PMID: 19571110 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)
Source: Clinical and Vaccine Immunology - June 30, 2009 Category: Allergy & Immunology Authors: Costa E, Tormo N, Clari MA, Bravo D, Muñoz-Cobo B, Navarro D Tags: Clin Vaccine Immunol Source Type: journals
Right Ventricular Fibroma in a 61-Year-Old Man
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We report on a 61-year-old man who presented with new negative T-waves in V3 to V5. Coronary heart disease with a nonsignificant stenosis of the anterior interventricular artery was known for three years without any symptoms of heart failure. Harvested endomyocardial biopsies of the left ventricle during catheterization showed a chronic parvovirus B19-associated myocarditis. A magnetic resonance imaging was carried out and showed a 6 × 3 × 3-cm mass in the right ventricle extending from the apex. The tumor could be completely resected using cardiopulmonary bypass. Histopathological diagnosis was c...
Source: The Thoracic and Cardiovascular Surgeon - June 25, 2009 Category: Cardiovascular & Thoracic Surgery Tags: Short Communications Source Type: journals
Detection of human parvovirus B19 in cases of hydrops fetalis in São Paulo, Brazil
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In this study, 40 pregnant women with gestational age of approximately 25 weeks, prenatal diagnosis of non immune hydrops fetalis and suspected of human parvovirus B19 infection were studied between January 1999 and December 2005. Serology results and detection of DNA in the maternal serum, foetal serum and amniotic fluid confirmed that 20 pregnant women had been infected by human parvovirus B19. The ultrasound examination demonstrated foetal hydrops, anaemia, hepatosplenomegaly, ascites, cardiopathy and amniotic fluid disorders. Among the positive cases, there were three fatal losses, one by miscarriage and two by intraut...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - June 25, 2009 Category: Pathology Source Type: journals
Clinical and epidemiological aspects of parvovirus B19 infections in Ireland, January 1996-June 2008
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Parvovirus B19 infection may be mistakenly reported as measles or rubella if laboratory testing is not performed. As Europe is seeking to eliminate measles, an accurate diagnosis of fever/rash illnesses is needed. The main purpose of this study was to describe the epidemiological pattern of parvovirus B19, a common cause of rash, in Ireland between January 1996 and June 2008, using times series analysis of laboratory diagnostic data from the National Virus Reference Laboratory. Most diagnostic tests for presumptive parvovirus B19 infection were done in children under the age of five years and in women of child-bearing age ...
Source: Eurosurveillance latest news - June 25, 2009 Category: Infectious Diseases Source Type: journals
Persistent parvovirus B19 infection detected by specific CD4+ T-cell responses in a patient with hepatitis and polyarthritis
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Abstract. Pongratz G, Lindner J, Modrow S, Schimanski S, Schölmerich J, Fleck M (University Medical Center Regensburg, Regensburg; Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg; and Asklepios-Clinic, Bad Abbach; Germany). Persistent parvovirus B19 infection detected by specific CD4+ T-cell responses in a patient with hepatitis and polyarthritis (Case Report). J Intern Med 2009; We, here, report the case of a parvovirus B19 infection in an immunocompetent male patient presenting with acute hepatitis and polyarthritis. To follow the course of infection, we used a previously established...
Source: Journal of Internal Medicine - June 24, 2009 Category: Internal Medicine Authors: G. Pongratz, J. Lindner, S. Modrow, S. Schimanski, J. Schölmerich, M. Fleck Source Type: journals
High Rate of Severe Fetal Outcomes Associated with Maternal Parvovirus B19 Infection in Pregnancy
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Conclusions. These findings suggest that parvovirus B19 infection in pregnancy follows seasonal and annual trend variation, may produce a lower frequency of maternal symptoms and a higher fetal loss rate than previously reported. Synopsis.
Maternal parvovirus B19 infection follows seasonal and annual variation is often asymptomatic and may have higher fetal loss rates than previously reported. Continued surveillance is warranted. (Source: Infectious Diseases in Obstetrics and Gynecology)
Source: Infectious Diseases in Obstetrics and Gynecology - June 9, 2009 Category: OBGYN Source Type: journals
Successful Treatment with High-Dose Intravenous Immunoglobulin for Parvovirus B19 Infection Associated With Acute Fulminant Hepatitis in a Chinese Child
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(Source: Clinical Pediatrics)
Source: Clinical Pediatrics - June 4, 2009 Category: Pediatrics Authors: Cao, Y.-H., Zhang, G.-Y., Zhang, G.-C. Tags: Article Source Type: journals
Melkersson–Rosenthal syndrome associated with parvovirus b19 viraemia and haemophagocytic lymphohistiocytosis
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We describe a 23-year-old patient who presented acutely with haemophagocytic lymphohistiocytosis (HL) and Melkersson[ndash]Rosenthal syndrome (MRS). MRS and HL are two unusual and complex clinical patterns that may present acutely and to our knowledge, an association between them has never been reported. The clinical investigations in this patient led to identification of parvovirus B19 (PB19) viraemia by PCR. Parvovirus infection has been reported as a cause of virus-associated HL, but the presence of PB19 has never been sought or reported as a possible trigger for MRS. This observation suggests a possible association bet...
Source: Clinical And Experimental Dermatology - May 31, 2009 Category: Dermatology Authors: A. De Maria, A. Zolezzi, G. Passalacqua, M. Leva, F. Tarchino, P. Spaggiari, S. Balestracci, G. W. Canonica Source Type: journals
Viral causes of human myocarditis.
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The diagnosis of acute myocarditis is complex and challenging. The use of the Dallas criteria in the diagnosis of myocarditis is associated with poor sensitivity and specificity because of the sampling error related to the often focal distribution of the specific histological lesions in cardiac tissue and the variability in pathological interpretation. To improve histological diagnosis, additional virological evaluation of cardiac tissues is required, with immunohistochemical and polymerase chain reaction (PCR) techniques allowing identification and quantification of viral infection markers. The diagnostic gold standar...
Source: Archives of Cardiovascular Diseases - May 31, 2009 Category: Cardiology Authors: Andréoletti L, Lévêque N, Boulagnon C, Brasselet C, Fornes P Tags: Arch Cardiovasc Dis Source Type: journals
No detection of human bocavirus in amniotic fluid samples from fetuses with hydrops or isolated effusions
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Conclusion: We suggest that HBoV is not a common cause of fetal hydrops, anemia or isolated effusions. This has to be confirmed by further studies of proven gestational HBoV infection. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - May 26, 2009 Category: Virology Authors: Martin Enders, Juha Lindner, Jürgen J. Wenzel, Carola Baisch, Gunnar Schalasta, Gisela Enders, Susanne Modrow Tags: Full length articles Source Type: journals
[PostScript] Searching for intraocular antibody production against Parvovirus B19, Mumps virus and Measles virus in patients with intermediate and posterior uveitis
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(Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 22, 2009 Category: Opthalmology Authors: Visser, N, Rothova, A, de Groot-Mijnes, J D F, de Visser, L Tags: PostScript Source Type: journals
Antibody-mediated opsonization of red blood cells in parvovirus B19 infection.
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In this study, we report that in early, acute or persistent infection, B19 viremia is mostly associated with RBCs. The capacity of different patients' plasma or IgG to opsonize RBCs collected from patients with early B19 infection, was investigated. The highest opsonization activity was observed with plasma or IgG fractions from patients with past B19 infection. In contrast, IgG samples from patients with acute or persistent infection showed no or little opsonization activity. The depletion of antibodies specific to B19 VP1, but not VP2, from IgG samples, resulted in a significant suppression of opsonization. Furthermore, ...
Source: Virology - May 16, 2009 Category: Virology Authors: Chehadeh W, Halim MA, Al-Nakib W Tags: Virology Source Type: journals
Acute arthropathy in patients with rash diseases: a comparative study
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Abstract The aim of this study was to assess the association of acute arthropathy and selected clinical features in patients with acute
rash diseases. Serum samples from 1,554 patients were tested for anti-measles, dengue, human parvovirus B19, and rubella virus
IgM using enzyme immunoassay. Sera from children, in whom these infections were excluded, were studied for anti-human herpesvirus
type 6 IgG antibodies using an indirect immunofluorescence test. Joint complaints occurred in 31.2% of the 862 patients with
an etiologic diagnosis and were more frequently seen in adults than in children (OR 8.5). Among t...
Source: Clinical Rheumatology - May 5, 2009 Category: Rheumatology Tags: Clinical Rheumatology Source Type: journals
Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease
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Acute splenic sequestration crisis (ASSC) is a hematological emergency in young children with sickle cell disease (SCD), characterized by worsening anemia and splenomegaly, usually with reticulocytosis and thrombocytopenia. Transient aplastic crisis (TAC) due to parvovirus B19 infection occurs in older children with SCD, and typically manifests as worsening anemia with reticulocytopenia and no splenomegaly. Five older children with SCD (4 HbSC, 1 HbSS on hydroxyurea) developed ASSC concurrent with TAC and had a severe clinical course. Our cases suggest that older children with SCD and acute parvovirus infection should be m...
Source: Pediatric Blood and Cancer - May 5, 2009 Category: Cancer & Oncology Authors: Amber Mayfield Yates, Jane S. Hankins, Nicole A. Mortier, Banu Aygun, Russell E. Ware Source Type: journals
