University of Pennsylvania
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Indices of orbitofrontal and prefrontal function in Cluster B and Cluster C personality disorders
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Abstract: Neuropsychological studies implicate disruption of frontal systems in personality disorders. Few studies have examined the performance of Cluster B and Cluster C personality disorder patients on tests of orbitofrontal (OFC) and prefrontal (PFC) cortex function. Patients carrying diagnoses of either Cluster B (n=56) or Cluster C (n=19) personality disorders were compared with healthy control subjects (n=61) on the Iowa Gambling Task and University of Pennsylvania Smell Identification Test. They also completed the Wechsler Abbreviated Scale of Intelligence as a control for general intellectual ability. On the gambl...
Source: Psychiatry Research - November 20, 2009 Category: Psychiatry Authors: Anthony C. Ruocco, Michael S. McCloskey, Royce Lee, Emil F. Coccaro Tags: Brief Reports Source Type: journals
Sangamo BioSciences Provides Update On Phase 1 Safety Trial Of SB-728-T For HIV/AIDSEmail this article to a colleague.
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Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced that data from the University of Pennsylvania investigator sponsored Phase 1 safety study of Sangamo's zinc finger nuclease (ZFN) based product, SB-728-T, for HIV/AIDS were inadvertently and prematurely disclosed on the internet. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: HIV / AIDS Source Type: news
Sangamo BioSciences Provides Update On Phase 1 Safety Trial Of SB-728-T For HIV/AIDSEmail this article to a colleague.
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Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced that data from the University of Pennsylvania investigator sponsored Phase 1 safety study of Sangamo's zinc finger nuclease (ZFN) based product, SB-728-T, for HIV/AIDS were inadvertently and prematurely disclosed on the internet. (Source: HIV / AIDS News From Medical News Today)
Source: HIV / AIDS News From Medical News Today - November 19, 2009 Category: Infectious Diseases Tags: HIV / AIDS Source Type: news
Sangamo BioSciences Provides Update on Phase 1 Safety Trial of SB-728-T for HIV/AIDSEmail this article to a colleague.
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RICHMOND, Calif., Nov. 18 /PRNewswire-FirstCall/ -- Sangamo
BioSciences, Inc. (NASDAQ:SGMO) announced today that data from the
University of Pennsylvania investigator sponsored Phase 1 safety
study of Sangamo's zinc finger nuclease (ZFN) based... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - November 18, 2009 Category: Pharmaceuticals Source Type: clinical trials
Vision and vacuum tubesEmail this article to a colleague.
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Sir Maurice Wilkes, 96, one of the pioneers of British computing, strolls through the history the he helped createWalk round the National Museum of Computing at Bletchley Park and sooner or later you'll hear a cry of recognition and someone will say: "I remember using one of those." It probably doesn't happen often to The Millionaire, a mechanical calculator that went into production in 1893, but Sir Maurice Wilkes spotted it, adding: "We used to have one in the lab. I hope it's still there."In this case, "the lab" was what became the Cambridge University Computer Lab, which Wilkes headed from 1945 until 1980. It was where...
Source: Guardian Unlimited Science - November 18, 2009 Category: Science Authors: Jack Schofield Tags: Computing Technology Science People in science Physics The Guardian Interviews Source Type: news
Antioxidant Found In Vegetables Has Implications For Treating Cystic FibrosisEmail this article to a colleague.
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Scientists at the University of Pennsylvania School of Medicine discovered that a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body's inflammatory response to infection and injury. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Cystic Fibrosis Source Type: news
Antioxidant Found In Vegetables Has Implications For Treating Cystic FibrosisEmail this article to a colleague.
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Scientists at the University of Pennsylvania School of Medicine discovered that a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body's inflammatory response to infection and injury. The finding has implications for such inflammation-based disorders as cystic fibrosis (CF), diabetes, heart disease, and neurodegeneration. (Source: Diabetes News From Medical News Today)
Source: Diabetes News From Medical News Today - November 18, 2009 Category: Endocrinology Tags: Cystic Fibrosis Source Type: news
Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriersEmail this article to a colleague.
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This study showed no evidence for altered risk of breast cancer for individuals with the GSTT1 and GSTM1 deletion variants, but did report that the GSTP1 Ile105Val (rs1695) variant was associated with increased breast cancer risk in carriers. We investigated the association
between these three GST polymorphisms and breast cancer risk using existing data from 718 women BRCA1 and BRCA2 mutation carriers from Australia, the UK, Canada, and the USA. Data were analyzed within a proportional hazards framework
using Cox regression. There was no evidence to show that any of the polymorphisms modified disease risk for BRCA1 or BR...
Source: Breast Cancer Research and Treatment - November 18, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Looped Penrose Drain for Minimally Invasive Treatment of Complex Superficial Abscesses of the HandEmail this article to a colleague.
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Abstract Complex superficial abscesses are a common occurrence that traditionally have been treated by making relatively large incisions
over the surface of the abscess, in order to ensure drainage and access for packing and dressing changes. The authors outline
a minimally invasive technique that can be used for draining complex subcutaneous abscesses that extend over a large surface
area. It is a simple technique utilizing multiple small incisions and looped penrose drains. This technique has been found
to be very effective in many areas of the body and has multiple advantages over traditional incision, dr...
Source: Hand - November 17, 2009 Category: Surgery Tags: Hand Source Type: journals
A Challenge To Dartmouth Atlas' Claims Of Wasteful Health Care SpendingEmail this article to a colleague.
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Kaiser Health News staff writer Jordan Rau reports on Dr. Richard Cooper's contrarian views. "Cooper, a 73-year-old University of Pennsylvania medical school professor, ... denounced as 'malarkey' a reigning premise of the health care debate -- that one-third of the nation's $2.5 trillion in annual health spending is unnecessary -- and said that the idea came from 'a bunch of clowns' (11/16). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 17, 2009 Category: Consumer Health News Tags: Public Health Source Type: news
A Challenge To Dartmouth Atlas' Claims Of Wasteful Health Care SpendingEmail this article to a colleague.
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Kaiser Health News staff writer Jordan Rau reports on Dr. Richard Cooper's contrarian views. "Cooper, a 73-year-old University of Pennsylvania medical school professor, ... denounced as 'malarkey' a reigning premise of the health care debate -- that one-third of the nation's $2. (Source: Public Health News From Medical News Today)
Source: Public Health News From Medical News Today - November 17, 2009 Category: Primary Care Tags: Public Health Source Type: news
Jeff Boyd, PhD, Appointed Chair of OCRF Scientific Advisory CommitteeEmail this article to a colleague.
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The Board of Directors of the Ovarian Cancer Research Fund (OCRF) is pleased to announce that Jeff Boyd, PhD, Chief Scientific Officer at the Fox Chase Cancer Center in Philadelphia, PA, has been appointed Chair of the OCRF Scientific Advisory Committee (SAC). The Board of Directors of the Ovarian Cancer Research Fund (OCRF) is pleased to announce that Jeff Boyd, PhD, Chief Scientific Officer at the Fox Chase Cancer Center in Philadelphia, PA, has been appointed Chair of the OCRF Scientific Advisory Committee (SAC). The Scientific Advisory Committee is charged with evaluating research proposals to ensure that OCRF's ...
Source: OCRF News - November 17, 2009 Category: Cancer & Oncology Source Type: organizations
Penn study finds that antioxidant found in vegetables has implications for treating cystic fibrosisEmail this article to a colleague.
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(University of Pennsylvania School of Medicine) Scientists at the University of Pennsylvania School of Medicine discovered that a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body's inflammatory response to infection and injury. The finding has implications for such inflammation-based disorders as cystic fibrosis, diabetes, heart disease and neurodegeneration. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 16, 2009 Category: Global & Universal Source Type: news
Urgency as the cardinal symptom of overactive bladder: a critical analysisEmail this article to a colleague.
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Content Type Journal ArticleCategory EditorialDOI 10.1007/s00345-009-0445-6Authors
Linda Cardozo, King’s College Hospital Urogynaecology 8 Devonshire Place London W1G 6HP UKChris Chapple, Sheffield Teaching Hospitals NHS Foundation Trust Sheffield S10 2JF UKAlan Wein, University of Pennsylvania School of Medicine 9 Penn Tower, 3400 Spruce St Philadelphia PA 19104 USA
Journal World Journal of UrologyOnline ISSN 1433-8726Print ISSN 0724-4983 (Source: World Journal of Urology)
Source: World Journal of Urology - November 14, 2009 Category: Urology & Nephrology Tags: World Journal of Urology Source Type: journals
Metronidazole-induced cerebellar toxicityEmail this article to a colleague.
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Content Type Journal ArticleCategory Clinical ImageDOI 10.1007/s00247-009-1453-9Authors
Jonathan A. Chatzkel, University of Pennsylvania School of Medicine Department of Radiology, Children’s Hospital of Philadelphia 34th St. and Civic Center Boulevard Philadelphia PA 19104 USAArastoo Vossough, University of Pennsylvania School of Medicine Department of Radiology, Children’s Hospital of Philadelphia 34th St. and Civic Center Boulevard Philadelphia PA 19104 USA
Journal Pediatric RadiologyOnline ISSN 1432-1998Print ISSN 0301-0449 (Source: Pediatric Radiology)
Source: Pediatric Radiology - November 13, 2009 Category: Radiology Tags: Pediatric Radiology Source Type: journals
Study Provides First Clear Idea Of How Rare Bone Disease ProgressesEmail this article to a colleague.
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An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ossificans progressiva (FOP), in which the body's skeletal muscles and soft connective tissue turns to bone, immobilizing patients over a lifetime with a second skeleton. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 13, 2009 Category: Consumer Health News Tags: Bones / Orthopaedics Source Type: news
Study Provides First Clear Idea Of How Rare Bone Disease ProgressesEmail this article to a colleague.
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An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ossificans progressiva (FOP), in which the body's skeletal muscles and soft connective tissue turns to bone, immobilizing patients over a lifetime with a second skeleton. (Source: Bones / Orthopaedics News From Medical News Today)
Source: Bones / Orthopaedics News From Medical News Today - November 13, 2009 Category: Orthopaedics Tags: Bones / Orthopaedics Source Type: news
Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured AdultsEmail this article to a colleague.
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Conclusions DCS measurements of CBF and NIRS measurements of tissue blood oxygenation were successfully obtained in neurocritical care
patients. The potential for DCS to provide continuous, noninvasive bedside monitoring for the purpose of CBF management and
individualized care is demonstrated.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9305-xAuthors
Meeri N. Kim, University of Pennsylvania Department of Physics and Astronomy 209 South 33rd Street Philadelphia PA 19104 USATurgut Durduran, University of Pennsylvania Department of Physics and Astronomy 209 South 33rd Str...
Source: Neurocritical Care - November 12, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals
Penn study provides first clear idea of how rare bone disease progressesEmail this article to a colleague.
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(University of Pennsylvania School of Medicine) An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ossificans progressiva (FOP), in which the body's skeletal muscles and soft connective tissue turns to bone, immobilizing patients over a lifetime with a second skeleton. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 12, 2009 Category: Global & Universal Source Type: news
Six Universities Aim To Expand Drug Access In Developing CountriesEmail this article to a colleague.
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Six universities have agreed to an effort to "encourage companies to give poor countries better access to drugs and medical products stemming from discoveries made on their campuses," Bloomberg reports (Lauerman, 11/9). For the effort - Boston University, Brown, Harvard, Oregon Health & Science University, the University of Pennsylvania and Yale - issued a statement (. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 11, 2009 Category: Consumer Health News Tags: Pharma Industry / Biotech Industry Source Type: news
Six Universities Aim To Expand Drug Access In Developing CountriesEmail this article to a colleague.
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Six universities have agreed to an effort to "encourage companies to give poor countries better access to drugs and medical products stemming from discoveries made on their campuses," Bloomberg reports (Lauerman, 11/9). For the effort - Boston University, Brown, Harvard, Oregon Health & Science University, the University of Pennsylvania and Yale - issued a (Source: HIV / AIDS News From Medical News Today)
Source: HIV / AIDS News From Medical News Today - November 11, 2009 Category: Infectious Diseases Tags: Pharma Industry / Biotech Industry Source Type: news
Subject of the year: Who are we missing, who are we overtreating, and who is best served? Refining the prescription of implantable cardioverter-defibrillator therapyEmail this article to a colleague.
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Content Type Journal ArticleCategory EDITOR’S FORUMDOI 10.1007/s10840-009-9439-yAuthors
Andrew E. Epstein, University of Pennsylvania Electrophysiology Section, Cardiovascular Division 9 Founders, 3400 Spruce Street Philadelphia PA 19104 USA
Journal Journal of Interventional Cardiac ElectrophysiologyOnline ISSN 1572-8595Print ISSN 1383-875X (Source: Journal of Interventional Cardiac Electrophysiology)
Source: Journal of Interventional Cardiac Electrophysiology - November 10, 2009 Category: Cardiology Tags: Journal of Interventional Cardiac Electrophysiology Source Type: journals
Effect of bevacizumab in older patients with metastatic colorectal cancer: pooled analysis of four randomized studiesEmail this article to a colleague.
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Conclusions In medically fit older patients, bevacizumab provides similar PFS and OS benefits as in younger patients.
Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0712-3Authors
James Cassidy, Cancer Research UK Glasgow UKLeonard B. Saltz, Memorial Sloan-Kettering Cancer Center New York NY USABruce J. Giantonio, University of Pennsylvania Philadelphia PA USAFairooz F. Kabbinavar, UCLA School of Medicine Los Angeles CA USAHerbert I. Hurwitz, Duke University Medical Center Durham NC USAUlrich-Peter Rohr, F. Hoffmann-La Roche Basel Switzerland
Journal Journal of Cancer Re...
Source: Journal of Cancer Research and Clinical Oncology - November 10, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals
David A. Asch, M.D., M.B.A., receives AAMC Distinguished Teacher AwardEmail this article to a colleague.
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(University of Pennsylvania School of Medicine) David A. Asch, M.D., M.B.A., the Robert D. Eilers Professor of Medicine and Health Care Management and Economics at the University of Pennsylvania School of Medicine and the Wharton School, was presented with the Alpha Omega Alpha Robert J. Glaser Distinguished Teacher Award by the Association American of Medical Colleges. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 10, 2009 Category: Global & Universal Source Type: news
Children with Special Physical Health Care Needs: Restraint Use and Injury Risk in Motor Vehicle CrashesEmail this article to a colleague.
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Abstract Physical disabilities may affect a child passenger’s fit within a conventional motor vehicle restraint. The aim of this study
is to describe and compare injury risk in motor vehicle crashes (MVC) among children with and without special physical health
care needs (SPHCN). This analysis, conducted in 2007–2008, utilizes data collected between December 1998 and November 2002
in a cross-sectional study of children ≤15 years old involved in crashes of State-Farm insured vehicles in 15 states and the
District of Columbia. Parent reports via telephone survey were used to define pre-crash SPHCN, ...
Source: Maternal and Child Health Journal - November 9, 2009 Category: Health Management Tags: Maternal and Child Health Journal Source Type: journals
Association Between Higher Carotid Arterial Stenting Rates And Poorer Clinical OutcomesEmail this article to a colleague.
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Among eligible Medicare beneficiaries, increased use of carotid arterial stenting (CAS) procedures to treat carotid stenosis - the narrowing of the carotid artery - is associated with higher rates of mortality and adverse clinical outcomes, including heart attack and stroke, according to researchers from the University of Pennsylvania School of Medicine. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 9, 2009 Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news
Association Between Higher Carotid Arterial Stenting Rates And Poorer Clinical OutcomesEmail this article to a colleague.
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Among eligible Medicare beneficiaries, increased use of carotid arterial stenting (CAS) procedures to treat carotid stenosis - the narrowing of the carotid artery - is associated with higher rates of mortality and adverse clinical outcomes, including heart attack and stroke, according to researchers from the University of Pennsylvania School of Medicine. (Source: Cardiovascular / Cardiology News From Medical News Today)
Source: Cardiovascular / Cardiology News From Medical News Today - November 9, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news
The pneumococcus: why a commensal misbehavesEmail this article to a colleague.
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Abstract Several characteristics of Streptococcus pneumoniae (pneumococcus) combine to make it a particularly problematic pathogen. Firstly, the pneumococcus has the capacity to cause
disease through the expression of virulence factors such as its polysaccharide capsule and pore-forming toxin. In addition,
the pneumococcus is highly adaptable as demonstrated by its ability to acquire and disseminate resistance to multiple antibiotics.
Although the pneumococcus is a major cause of disease, the organism is most commonly an “asymptomatic” colonizer of its human
host (the carrier state), with transmission oc...
Source: Journal of Molecular Medicine - November 6, 2009 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals
Higher carotid arterial stenting rates associated with poorer clinical outcomesEmail this article to a colleague.
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(University of Pennsylvania School of Medicine) Among eligible Medicare beneficiaries, increased use of carotid arterial stenting procedures to treat carotid stenosis -- the narrowing of the carotid artery -- is associated with higher rates of mortality and adverse clinical outcomes, including heart attack and stroke, according to researchers from the University of Pennsylvania School of Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 6, 2009 Category: Global & Universal Source Type: news
How the heart is formed?Email this article to a colleague.
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While studying how the heart is formed, researchers at the University of Pennsylvania School of Medicine serendipitously found a novel cellular source of atrial fibrillation (AF), the most common type of abnormal heart beat. Jonathan Epstein, MD, William Wikoff Smith Professor, and Chair, Department of Cell and Developmental Biology, and Vickas Patel, MD, PhD, Assistant Professor of Medicine, have identified a population of cells in the atria of the heart and pulmonary veins of humans and mice that appear to be the seat of AF. The finding may lead to a more precise way to treat AF, with reduced side effects. Their finding...
Source: Medicineworld.org: New Article Alert - November 5, 2009 Category: Consumer Health News Source Type: info
Cellular Source Of Most Common Type Of Abnormal Heart Beat Study: Findings Could Point To More Precise Treatments For Atrial FibrillationEmail this article to a colleague.
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While studying how the heart is formed, scientists at the University of Pennsylvania School of Medicine serendipitously found a novel cellular source of atrial fibrillation (AF), the most common type of abnormal heart beat. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 5, 2009 Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news
Cellular Source Of Most Common Type Of Abnormal Heart Beat Study: Findings Could Point To More Precise Treatments For Atrial FibrillationEmail this article to a colleague.
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While studying how the heart is formed, scientists at the University of Pennsylvania School of Medicine serendipitously found a novel cellular source of atrial fibrillation (AF), the most common type of abnormal heart beat. (Source: Cardiovascular / Cardiology News From Medical News Today)
Source: Cardiovascular / Cardiology News From Medical News Today - November 5, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news
Penn's Arthur H. Rubenstein receives Distinguished Service award from AAMCEmail this article to a colleague.
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(University of Pennsylvania School of Medicine) Arthur H. Rubenstein, MBBCh, Executive Vice President of the University of Pennsylvania for the Health System, and Dean, School of Medicine, will receive the Abraham Flexner Award for Distinguished Service to Medical Education from the Association of American Medical Colleges. The award will be presented on Saturday, Nov. 7, during the association's annual meeting in Boston. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 5, 2009 Category: Global & Universal Source Type: news
Epidemiology and Impact of Imipenem Resistance in Acinetobacter baumannii • Email this article to a colleague.
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Conclusions. Many A. baumannii isolates exhibit imipenem resistance, which is strongly associated with prior use of carbapenems. Given the high mortality rate associated with A. baumannii infection or colonization, interventions to curb further emergence of cases of IRAB infection and strategies to optimize therapy are needed. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - November 4, 2009 Category: Epidemiology Tags: article Original Article Source Type: journals
Weight training for breast cancer survivorsEmail this article to a colleague.
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In addition to building muscle, weightlifting is also a prescription for self-esteem among breast cancer survivors, as per new University of Pennsylvania School of Medicine research. Breast cancer survivors who lift weights regularly feel better about bodies and their appearance and are more satisfied with their intimate relationships compared with survivors who do not lift weights, as per a newly released study reported in the journal Breast Cancer Research and Treatment........ (Source: Medicineworld.org: New Article Alert)
Source: Medicineworld.org: New Article Alert - November 4, 2009 Category: Consumer Health News Source Type: info
Weight Training Boosts Breast Cancer Survivors' Body Image And Satisfaction With Intimate RelationshipsEmail this article to a colleague.
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In addition to building muscle, weightlifting is also a prescription for self-esteem among breast cancer survivors, according to new University of Pennsylvania School of Medicine research. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 4, 2009 Category: Consumer Health News Tags: Breast Cancer Source Type: news
Penn Biologists Say There's A Speed Limit To The Pace Of EvolutionEmail this article to a colleague.
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Researchers at the University of Pennsylvania have developed a theoretical model that informs the understanding of evolution and determines how quickly an organism will evolve using a catalogue of "evolutionary speed limits. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 4, 2009 Category: Consumer Health News Tags: Biology / Biochemistry Source Type: news
Penn researchers describe cellular source of most common type of abnormal heart beatEmail this article to a colleague.
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(University of Pennsylvania School of Medicine) While studying how the heart is formed, scientists serendipitously found a novel cellular source of atrial fibrillation (AF), the most common type of abnormal heart beat. They identified a population of cells in the atria of the heart and pulmonary veins of humans and mice that appear to be the seat of AF. The finding may lead to a more precise way to treat AF, with reduced side effects. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 4, 2009 Category: Global & Universal Source Type: news
Breast cancer risks in individuals testing negative for a known family mutation in BRCA1 or BRCA2Email this article to a colleague.
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Abstract Genetic testing for BRCA1 and BRCA2 mutations in family members of individuals with known deleterious mutations can distinguish between patients at high risk
of disease and those who are not. Some studies have suggested that individuals testing negative for known familial mutations
(true negatives), may still have a higher risk of breast cancer (BC) than the general population. We have examined a prospectively
followed cohort of true negative women in the US. Subjects were close relatives of known BRCA1 and BRCA2 mutation carriers who had undergone genetic testing, were negative for the known familia...
Source: Breast Cancer Research and Treatment - November 3, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Weight training boosts breast cancer survivors' body image and intimate relationship satisfactionEmail this article to a colleague.
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(University of Pennsylvania School of Medicine) In addition to building muscle, weightlifting is also a prescription for self-esteem among breast cancer survivors, according to new University of Pennsylvania School of Medicine research. Breast cancer survivors who lift weights regularly feel better about bodies and their appearance and are more satisfied with their intimate relationships compared with survivors who do not lift weights, according to a new study published in the journal Breast Cancer Research and Treatment. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 3, 2009 Category: Global & Universal Source Type: news
Penn Medicine leads $45 million NIH-supported trial to study testosterone therapy in older menEmail this article to a colleague.
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(University of Pennsylvania School of Medicine) Penn Medicine will lead a $45 million clinical trial to test whether testosterone therapy can favorably affect certain conditions affecting older men. Low serum testosterone may contribute to problems affecting older men, including decreased ability to walk, loss of muscle mass and strength, decreased vitality, decreased sexual function, impaired cognition, cardiovascular disease and anemia. While testosterone normally decreases with age, in some men, low levels of testosterone may contribute to these debilitating conditions. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 2, 2009 Category: Global & Universal Source Type: news
There's a speed limit to the pace of evolution, Penn biologists sayEmail this article to a colleague.
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(University of Pennsylvania) A major conclusion of the work is that for some organisms, possibly including humans, continued evolution will not translate into ever-increasing fitness. Moreover, a population may accrue mutations at a constant rate -- a pattern long considered the hallmark of "neutral" or non-Darwinian evolution -- even when the mutations experience Darwinian selection. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 2, 2009 Category: Biology Source Type: news
Obstetric Residencies Ranked by Grads' SkillsEmail this article to a colleague.
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Obstetric residency programs can be ranked according to the complication rates among patients delivered by the programs' graduates, according to a report in JAMA. Moreover, the difference in maternal complication rates between graduates of the highest-ranked residency programs and graduates of the lowest-ranked programs was deemed relatively large. “A woman choosing an obstetrician who trained at a program in the top tier would face a 10.3% risk of a major complication, compared with 13.6% if she chose an obstetrician trained at a program from the bottom tier,” said Dr. David A. Asch of the Leonard Davis Institute of ...
Source: Ob.Gyn. News - November 1, 2009 Category: OBGYN Authors: MARY ANN MOON Tags: Practice Trends Source Type: journals
Tell ‘Em What You Want!Email this article to a colleague.
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As patients become more involved in their health care, the demand for access to health information has grown accordingly. Four of every 10 cancer patients look for cancer treatment information on the Internet. A study by Dr Stacy Gray and colleagues of the University of Pennsylvania Annenberg School assessed the relationship between information-seeking among 633 patients with colorectal cancer and the use of new treatments (bevacizumab and cetuximab) for the disease. Patients who sought information about possible treatments were 2.83 times more likely to know about these targeted therapies and 3.22 times more likely to rec...
Source: Dental Abstracts - November 1, 2009 Category: Dentistry Tags: Extracts Source Type: journals
Should There Be Direct Entry from a BSN Program Into an NP Graduate Program?Email this article to a colleague.
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Deborah Becker, PhD, RN, ACNP-BC, assistant professor, is the director of the Adult Acute Care NP Program and the Adult Health CNS Program at the University of Pennsylvania. She is a graduate of Villanova University (BS), Thomas Jefferson University School of Allied Health (BSN), the University of Pennsylvania School of Nursing (MSN and post-master's nurse practitioner certificate), and Drexel University School of Education (PhD). She is a member of the American Association of Critical Care Nurses, the American Heart Association Cardiovascular Nursing Council, and Sigma Theta Tau. (Source: The Journal for Nurse Practitioners)
Source: The Journal for Nurse Practitioners - November 1, 2009 Category: Nursing Authors: Janet Selway Tags: Point/Counterpoint Source Type: journals
FDG PET/CT in carcinoma of unknown primaryEmail this article to a colleague.
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This article will review the
use, diagnostic performance, and utility of FDG PET/CT in CUP and will discuss challenges and future considerations in the
diagnostic management of CUP.
Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s00259-009-1295-6Authors
Thomas C. Kwee, University Medical Center Utrecht Department of Radiology Heidelberglaan 100 3584 CX Utrecht The NetherlandsSandip Basu, Hospital of the University of Pennsylvania Division of Nuclear Medicine, Department of Radiology Philadelphia PA USAGang Cheng, Hospital of the University of Pennsylvania Division of Nuclear Medicine, Department of R...
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 31, 2009 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals
The molecular biology of addictive drugsEmail this article to a colleague.
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This article reviews those experiments that have studied drug-induced alterations in gene transcription.
Ethanol has diverse effects on the amounts of messenger RNA molecules within the central nervous system. Ion channels, neuropeptides,
membrane receptors, and immediate early genes represent several regulated mRNAs. The effects are selective, however, as many
other specific products are not altered. Evidence for a genetic predisposition to ethanol use reinforces the importance of
the genotype.
Opioids, cocaine, and amphetamine also affect gene transcription. Messenger RNAs studied have included many of those...
Source: Molecular Neurobiology - October 29, 2009 Category: Neurology Tags: Molecular Neurobiology Source Type: journals
Inhibitor of heat shock protein is a potential anticancer drug, Penn study findsEmail this article to a colleague.
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(University of Pennsylvania School of Medicine) Researchers identified a small molecule that inhibits the heat shock protein HSP70. They also showed that the HSP inhibitor, called PES, could stop tumor formation, and significantly extend survival of mice. PES seems to be specifically targeting HSP70, a protein that is differentially expressed in normal vs. cancerous cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 29, 2009 Category: Global & Universal Source Type: news
Gene Therapy Restores Sight To Children With Congenital BlindnessEmail this article to a colleague.
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Results from a breakthrough study, conducted by researchers at The Children's Hospital of Philadelphia (CHOP) and the University of Pennsylvania School of Medicine, show that gene therapy has restored significant vision in five children and seven adults who were previously blind. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 28, 2009 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news
The effect of the antiscatter grid on full-field digital mammography phantom imagesEmail this article to a colleague.
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This article reports on a recent application of this method to a prototype full-field digital mammography (FFDM) machine.
Images of a modified ACR phantom were acquired on the General Electric Diagnostic Molybdenum Rhodium (GE-DMR) FFDM machine
at a number of x-ray techniques, both with and without the scatter reduction grid. The techniques were chosen so that one
had sets of grid and non-grid images with matched doses (200 mrads) and matched gray-scale values (1500). A third set was
acquired at constant 26 kVp and varying mAs for both grid conditions. Analyses of the images yielded signal-to-noise-ratio
(SNR), contra...
Source: Journal of Digital Imaging - October 28, 2009 Category: Radiology Tags: Journal of Digital Imaging Source Type: journals
