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Vagus Nerve Stimulation for Generalized Epilepsy?…Show Me the Evidence!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epilepsy Currents, Volume 8, Issue 2, Page 35-36, March/April 2008. Is Vagus Nerve Stimulation a Treatment Option for Patients with Drug-Resistant Idiopathic Generalized Epilepsy? Kostov H, Larsson PG, Røste GK. Acta Neurol Scand Suppl 2007;187:55–58. BACKGROUND: The value of vagus nerve stimulation (VNS) for treating ...
Source: Epilepsy Currents - February 27, 2008 Category: Neurology Tags: article Source Type: journals

Vagus nerve stimulation: current concepts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vagus nerve stimulation (VNS) has become an accepted treatment option for pharmacologically resistant epilepsy. Although initially approved for adults, it increasingly has gained acceptance in children. In this article the author reviews the current state of knowledge of VNS therapy and discusses its potential utility. PMID: 18759633 [PubMed - as supplied by publisher]
Source: Neurosurgical Focus - September 1, 2008 Category: Neurosurgery Authors: Mapstone TB Tags: Neurosurg Focus Source Type: journals

Vagus nerve stimulation might have a unique effect in reflex eating seizuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We studied the effects of vagus nerve stimulation (VNS) on eating seizures, which theoretically would be triggered by neural activity and signaling from organs innervated by the vagus nerve. Three adult patients with daily nonreflex and reflex eating seizures were studied; one patient also had hot-water seizures. One patient had bilateral polymicrogyria and two had normal magnetic resonance imaging (MRI) findings. All patients were submitted to VNS implantation and had at least 2 years of postimplantation follow-up. Final stimulation parameters were 2.0[ndash]2.5 mA, 500 [mu]s, and 30 Hz. Eating seizures decreased 70[ndash...
Source: Epilepsia - September 22, 2009 Category: Neurology Authors: Arthur Cukiert, Pedro Paulo Mariani, Jose Augusto Burattini, Cristine Mella Cukiert, Cassio Forster, Carla Baise, Meire Argentoni-Baldochi, Valeria Mello Source Type: journals

New Study Supports Efficacy Of Vagus Nerve Stimulation For Treatment-Resistant DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medical University of South Carolina (MUSC) today announced the results of a functional MRI (fMRI) study examining the effects of VNS (Vagus Nerve Stimulation) Therapy(TM) for patients with treatment-resistant depression (TRD). The study, led by Ziad Nahas, M.D., associate professor, MUSC Department of Psychiatry, appears in the August 2007 issue of peer-reviewed Neuropsychopharmacology. The results show that VNS Therapy modulates areas of the brain that control mood. [click link for full article]
Source: Depression News From Medical News Today - August 21, 2007 Category: Psychiatry Source Type: news

FDA approves Demipulse and Demipulse Duo Generators for use in vagus nerve stimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cyberonics, Inc. has announced that the Demipulse and Demipulse Duo Generators for use in Vagus Nerve Stimulation ("VNS") Therapy were approved by the United States Food and Drug Administration ("FDA") for commercial release.
Source: News-Medical News Feed - July 18, 2007 Category: Consumer Health News Source Type: news

Noninvasive techniques for probing neurocircuitry and treating illness: vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gary Aston-Jones Keywords: TMS, VNS, neuromodulation
Source: Neuropsychopharmacology - July 19, 2009 Category: Neurology Authors: Mark S GeorgeGary Aston-Jones Source Type: journals

Vagus nerve stimulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vagus nerve stimulation (VNS) is a key tool in the treatment of patients with medically refractory epilepsy. Although the mechanism of action of VNS remains poorly understood, this modality is now the most widely used nonpharmacological treatment for drug-resistant epilepsy. The goal of this work is to review the history of VNS and provide information on recent advances and applications of this technology. PMID: 19722820 [PubMed - in process]
Source: Neurosurgical Focus - September 1, 2009 Category: Neurosurgery Authors: Lulic D, Ahmadian A, Baaj AA, Benbadis SR, Vale FL Tags: Neurosurg Focus Source Type: journals

Vagus Nerve Stimulation in the Treatment of Refractory EpilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Many patients with epilepsy suffer from persistent seizures despite maximal anti-epileptic drug therapy. Chronic, intermittent vagus nerve stimulation has been proven to be an effective option for many patients suffering from refractory seizures who are not candidates for surgical resection. Although only a small minority of patients will be entirely seizure-free, vagus nerve stimulation, as an adjunct to medical therapy, may result in significant improvements in quality of life. Vagus nerve stimulation is generally well-tolerated, as device implantation is associated with a low rate of perioperative complications...
Source: Neurotherapeutics - April 1, 2009 Category: Neurology Authors: Andrew H. Milby, Casey H. Halpern, Gordon H. Baltuch Tags: Theme 1: Brain Stimulation and Cooling Source Type: journals

Clinical Benefits and Cost Effectiveness of Vagus Nerve Stimulation in a Long-term Treatment of Patients with Major DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pharmacopsychiatry 2009; 42: 85-88DOI: 10.1055/s-0028-1103294Abstract To evaluate clinical aspects and cost effectiveness of the treatment with vagus nerve stimulation (VNS), a group of 9 VNS-implanted patients and 9 age- and sex-matched patients suffering from treatment-resistant depression were included in a prospective study.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text
Source: Pharmacopsychiatry - May 19, 2009 Category: Psychiatry Tags: Original Paper Source Type: journals

FDA Approves Demipulse and Demipulse Duo GeneratorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HOUSTON, July 16 (HSMN NewsFeed) -- Cyberonics, Inc. (Nasdaq: CYBX ) today announced that the Demipulse(TM) and Demipulse Duo(TM) Generators for use in Vagus Nerve Stimulation ("VNS") Therapy were approved by the United States Food and Drug Adm... Devices, Neurology, FDACyberonics, Demipulse, Vagus Nerve Stimulation, neuromodulation
Source: HSMN NewsFeed - July 16, 2007 Category: Pharmaceuticals Source Type: news

Long-term effect of vagus nerve stimulation on interictal epileptiform discharges in refractory epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: Vagus nerve stimulation (VNS) therapy has been widely recognized as an effective alternative for the treatment of refractory epilepsy. However, the precise mechanism of VNS is poorly understood. The purpose of this study was to observe the long-term interictal EEG changes induced by VNS, and to investigate the probable mechanism of action of VNS in achieving seizure control.Methods: Eight patients with VNS were selected from two epilepsy centers in China (Harbin and Shanghai) between 2001 and 2004. We studied the clinical efficacy by long-term follow-up, ranging from 37 to 81 months (mean 55.8 month...
Source: Journal of the Neurological Sciences - May 12, 2009 Category: Neurology Authors: Haiyang Wang, Xiaoguang Chen, Zhiguo Lin, Zhengbo Shao, Bomin Sun, Hong Shen, Li Liu Tags: Original Articles Source Type: journals

Vagus Nerve Stimulation May Treat Refractory Rapid-Cycling Bipolar DisorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results of a small open-label study indicate that vagus nerve stimulation (VNS) may be an effective and well-tolerated option in patients with treatment-resistant rapid-cycling bipolar disorder. Reuters Health Information
Source: Medscape Medical News Headlines - March 24, 2008 Category: Consumer Health News Tags: Psychiatry Source Type: news

Cardiac responses of vagus nerve stimulation: Intraoperative bradycardia and subsequent chronic stimulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In case of intraoperative bradycardia VNS-therapy onset should be done under ECG-monitoring. Subsequent chronic stimulation is safe in respect to heart rate. Bradycardia during intraoperative device testing is no reason to abort the operation. PMID: 17825483 [PubMed - as supplied by publisher]
Source: Clinical Neurology and Neurosurgery - September 5, 2007 Category: Neurosurgery Authors: Ardesch JJ, Buschman HP, van der Burgh PH, Wagener-Schimmel LJ, van der Aa HE, Hageman G Tags: Clin Neurol Neurosurg Source Type: journals

Vagus Nerve Stimulation, Sleep Apnea, and CPAP TitrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epilepsy and obstructive sleep apnea (OSA) are two relatively common disorders known to coexist and potentially exacerbate each other.1 Vagus nerve stimulation (VNS) is a currently used, adjunctive treatment for partial epilepsy and is generally well tolerated with few associated side effects. Some of the more common side effects include hoarseness of voice, laryngeal irritation and cough, especially after VNS current increases and the first few weeks of treatment. VNS therapy also affects respiration during sleep and has been shown to worsen preexisting obstructive sleep apnea/hypopnea syndrome (OSAHS) by increasing the n...
Source: Journal of Clinical Sleep Medicine : JCSM - October 16, 2008 Category: Sleep Medicine Source Type: journals

Vagus nerve stimulation may be used in the therapy of myocarditisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Although a large number of different causes have been identified as leading to myocarditis, inflammation plays a pivotal role in its pathological process. No specific methods are available in the therapy of myocarditis except symptomatic treatment. Vagus nerve stimulation has been found to lower the heart rate and recover the normal heart rhythm which may relieve the cardiac symptoms in myocarditis. Furthermore, the acetylcholine that secreted by vagus nerve stimulation was found to inhibit the production of such inflammatory cytokines as tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β). Based on the ab...
Source: Medical Hypotheses - June 1, 2009 Category: Biomedical Science Authors: Hong Li, Tian-De Yang Source Type: journals

Centers for Medicare and Medicaid Services (CMS) Declines Cyberonics' Formal Request to Expand Coverage of VNS TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Expanded Reimbursement Coverage Sought for VNS Therapy for Treatment-Resistant Depression HOUSTON, Feb. 5 /PRNewswire-FirstCall/ -- Cyberonics, Inc. (NASDAQ:CYBX) today announced that the Centers for Medicare and Medicaid Services (CMS) has declined the Company's formal request for reconsideration of its existing coverage policy for Vagus Nerve Stimulation (VNS) Therapy....
Source: Drug Newswire - February 7, 2007 Category: Pharmaceuticals Source Type: news

Late-onset periodic asystolia during vagus nerve stimulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present another case of late asystole in a patient whose VNS had been implanted 9 years before the arrhythmia onset. In our patient, each run of stimulation produced bradyarrhythmias and very often severe asystolia due to atrium-ventricular block. PMID: 19055490 [PubMed - as supplied by publisher]
Source: Epilepsia - December 2, 2008 Category: Neurology Authors: Iriarte J, Urrestarazu E, Alegre M, Macías A, Gómez A, Amaro P, Artieda J, Viteri C Tags: Epilepsia Source Type: journals

New Study Supports Efficacy of Vagus Nerve Stimulation for Treatment-Resistant DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mark S. George, M.D. Named Editor-in-Chief of New Brain Stimulation Journal CHARLESTON, S.C., Aug. 20 (HSMN NewsFeed) -- Medical University of South Carolina (MUSC) today announced the results of a functional MRI (fMRI) study examining the effects of ... Devices, NeurologyVagus Nerve Stimulation, VNS Therapy
Source: HSMN NewsFeed - August 20, 2007 Category: Pharmaceuticals Source Type: news

Tonic and atonic seizures: What's next—VNS or callosotomy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medically intractable tonic and atonic seizures may be responsive to either vagus nerve stimulation (VNS) or corpus callosum section. VNS has been shown to be effective and is associated with very low morbidity. Callosotomy is a more ambitious procedure, with a higher risk of complications but greater likelihood of seizure improvement.
Source: Epilepsia - August 12, 2009 Category: Neurology Authors: William E. Rosenfeld, David W. Roberts Source Type: journals

Vagus nerve stimulation: Can it be used in adolescents or children with treatment-resistant depression?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Vagus nerve stimulation (VNS) therapy has been approved by the US Food and Drug Administration for treatment-resistant depression in patients 18 years of age and older and for intractable epilepsy. Long-term studies suggest VNS has an antidepressant effect in adults. This paper reviews the available clinical data for VNS therapy. Its potential application for treatment-resistant depression in adolescents and children is also discussed. Content Type Journal ArticleDOI 10.1007/s11920-008-0021-6Authors Zheya Jenny Yu, Children’s Hospital of Philadelphia 3440 Market Street, 2nd Floor Philadelphia ...
Source: Current Psychiatry Reports - May 5, 2008 Category: Psychiatry Tags: Current Psychiatry Reports Source Type: journals

Cyberonics, Inc - VNS Therapy System Generator - Class 3 RecallEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cyberonics VNS Therapy Demipulse Generator, Model 103; an implantable, multiprogrammable, vagus nerve stimulator.
Source: Medical Device Recalls since July 07, 2006 - April 23, 2009 Category: Medical Equipment Source Type: organizations

Cyberonics, Inc - VNS Therapy System Generator - Class 3 RecallEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cyberonics VNS Therapy Demipulse Duo Generator, Model 104; an implantable, multiprogrammable, vagus nerve stimulator.
Source: Medical Device Recalls since July 07, 2006 - April 23, 2009 Category: Medical Equipment Source Type: organizations

[Vagus nerve stimulation for the treatment of refractory epilepsy.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Proposed as an additive symptomatic treatment of refractory epilepsy, vagus nerve stimulation (VNS) has proven to be effective and well-tolerated in patients presenting with refractory epilepsy for whom cortical resection is not indicated. After two years of treatment, the overall reduction of seizure frequency averaged 40%. In 50% of the patients, the frequency of seizures decreased by at least 50%. Moreover, even in absence of a significant reduction of seizures, patients who undergo this treatment reported an improvement in their quality of life. Economic surveys also demonstrate a favorable impact of VNS on the man...
Source: Neuro-Chirurgie - April 16, 2008 Category: Neurosurgery Authors: Roux FX, Turak B, Landré E Tags: Neurochirurgie Source Type: journals

Vagus Nerve Stimulation Therapy for Treatment of Drug-Resistant Epilepsy and DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vagal nerve stimulation therapy is a new adjunctive treatment for drug-resistant epilepsy and depression. It consists of a pulse generator that transmits impulses to the left vagus nerve via an implantable electrode and can be performed by surgeons familiar with the anatomy of the cervical vagus nerve. The minimum age for vagal nerve stimulation therapy for epilepsy is 12 years, and for depression, 18 years. Hoarseness and cough are the most common side effects. Response rates to vagal nerve stimulation therapy vary and depend on several other factors. If used as adjunctive therapy, vagal nerve stimulation has shown better...
Source: Perspectives in Vascular Surgery and Endovascular Therapy - March 9, 2007 Category: Surgery Authors: Shafique, S., Dalsing, M. C. Tags: Article Source Type: journals

Lutheran General Hospital Neurologist Treats Epilepsy With Vagal Nerve Stimulation (VNS) TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Daniel Brewer of Palatine has gone from having four to five epileptic seizures a day to a few minor ones in the six months since his surgery for vagal nerve stimulation (VNS) therapy to help control electric signals from his brain.
Source: Health News from Medical News Today - November 7, 2008 Category: Consumer Health News Tags: Epilepsy Source Type: news

[Vagus nerve stimulation for the treatment of refractory epilepsy. State of the art.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The vagus nerve stimulation (VNS) therapy is a new neurostimulation technique used for treating pharmacoresistant epilepsy. It can be considered an effective and safe alternative for the treatment of refractory epilepsy patients. In the present review, we describe the surgical implantation technique, its indications and results achieved until now. We will also summarize the possible mechanisms of action of VNS therapy. Finally, we will comment on the difficulties and inconvenients that did not allow this antiepileptic surgical technique to become more widely used. PMID: 18936858 [PubMed - as supplied by publisher]
Source: Neurocirugia - October 1, 2008 Category: Neurosurgery Authors: García-March G, Sánchez-Ledesma MJ, Broseta J Tags: Neurocirugia (Astur) Source Type: journals

Discovery Health Channel to Feature Medical Breakthrough Treatment for Depression, Vagus Nerve Stimulation, June 26, 9 p.m. EDTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 'Medical Incredible' series will feature Charles E. Donovan III, a former sufferer of chronic depression and patient in the study of vagus nerve stimulation therapy for chronic depression. Donovan is author of 'Out of the Black Hole: The Patient's Guide to Vagus Nerve Stimulation and Depression' and founder of...
Source: Drug Newswire - June 20, 2006 Category: Pharmaceuticals Source Type: news

Animal model of the short-term cardiorespiratory effects of intermittent vagus nerve stimulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Various VNS parameter settings induce different and concomitant cardiorespiratory variations in conscious sleeping rats. These effects correlate with the intensity of the VNS parameters. Understanding the effects of the intensity of VNS parameters may allow for further optimization of VNS parameters in patients receiving VNS. PMID: 18757249 [PubMed - as supplied by publisher]
Source: Autonomic Neuroscience - August 29, 2008 Category: Neuroscience Authors: Zaaimi B, Grebe R, Wallois F Tags: Auton Neurosci Source Type: journals

Vagus nerve stimulation confuses appetite: Comment on Bodenlos et al. (2007).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a recent research report, Bodenlos et al. [2007. Vagus nerve stimulation (VNS) acutely alters food craving in adults with depression. Appetite, 48, 145-153] concluded that, in depressed patients, acute activation of a device for VNS caused a significant change in cravings specifically for sweet foods. We argue that there is no evidence for any effect on food cravings. Rather, the findings indicate that VNS confuses the patient's appetite for sweet foods: this might result from contextually unexpected internal afferent signals generated by the vagal stimulation. Unfortunately, their multiple regression of potential p...
Source: Appetite - October 26, 2007 Category: Nutrition Authors: Gibson EL, Mohiyeddini C Tags: Appetite Source Type: journals

Effects of vagus nerve stimulation on rat hippocampal progenitor proliferation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vagus nerve stimulation (VNS), used in the treatment of epilepsy, was approved recently for treatment-resistant depression. The mechanisms of action of the VNS anti-depressive effects are not yet fully elucidated. Modulation of hippocampal neurogenesis has been proposed as an important factor in depression pathogenesis. We evaluated the effects of VNS on hippocampal progenitor turnover in the adult rat brain. Rats receiving VNS at the output current of 0.75 mA VNS for 2 days showed a significant 50% increase in dentate gyrus BrdU-incorporation consistent with an increase in progenitor proliferation. Output currents of ...
Source: Experimental Neurology - September 4, 2008 Category: Neurology Authors: Revesz D, Tjernstrom M, Ben-Menachem E, Thorlin T Tags: Exp Neurol Source Type: journals

Vagus nerve stimulation affects pain perception in depressed adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: VNS appears to affect pain perception in depressed adults. Different VNS parameter settings may be associated with unique effects from patient to patient. More studies are needed to determine the long-term effects of VNS on pain perception. PMID: 15782242 [PubMed - indexed for MEDLINE]
Source: Pain Research and Management - January 1, 2005 Category: Anesthesiology Authors: Borckardt JJ, Kozel FA, Anderson B, Walker A, George MS Tags: Pain Res Manag Source Type: journals

Vagus Nerve Stimulation for Intractable Epilepsy: Outcomes in Children and AdultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These results suggest that VNS may be a more effective treatment in children with intractable epilepsy than in adults. It remains difficult to predict which patients will respond to VNS therapy.
Source: Neuromodulation - August 20, 2009 Category: Neurology Authors: Won Chul Namgung, Tae Sung Ko, Sang-Ahm Lee, Joong Ku Kang, Seok Ho Hong, Il Young Shin, Jung-Kyo Lee Source Type: journals

Vagus nerve stimulation in intractable childhood epilepsy: a korean multicenter experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We evaluated the long-term outcome of vagus nerve stimulation (VNS) in 28 children with refractory epilepsy. Of these 28 children, 15 (53.6%) showed a >50% reduction in seizure frequency and 9 (32.1%) had a >75% reduction. When we compared seizure reduction rates according to seizure types (generalized vs. partial) and etiologies (symptomatic vs. cryptogenic), we found no significant differences. In addition, there was no correlation between the length of the stimulation period and treatment effect. The seizure reduction rate, however, tended to be inversely related to the seizure duration before VNS implantation...
Source: J Korean Med Sci - June 1, 2007 Category: Journals (General) Authors: You SJ, Kang HC, Kim HD, Ko TS, Kim DS, Hwang YS, Kim DS, Lee JK, Park SK Tags: J Korean Med Sci Source Type: journals

Cyberonics Receives FDA Real-Time Review Approval for New VNS Therapy Perennia LeadEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HOUSTON, July 18 /PRNewswire-FirstCall/ -- Cyberonics, Inc. (NASDAQ:CYBX) today announced that it received FDA Real-Time Review approval for its new VNS Therapy(TM) Perennia(TM) Lead. The Perennia Lead, which is connected to the VNS Therapy System Generator and attached to the left vagus nerve, can be used with the current Model...
Source: Drug Newswire - July 19, 2006 Category: Pharmaceuticals Source Type: news

Vagus nerve stimulation for intractable epilepsy in tuberous sclerosis complex.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The findings suggest that the vagus nerve stimulation can be an effective and safe therapy for patients with TSC with intractable epilepsy. PMID: 18468492 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - May 7, 2008 Category: Neurology Authors: Major P, Thiele EA Tags: Epilepsy Behav Source Type: journals

Comparison of corpus callosotomy and vagus nerve stimulation in children with Lennox-Gastaut syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The efficacy and safety of corpus callosotomy and VNS were comparable in children with LGS. PMID: 17825516 [PubMed - as supplied by publisher]
Source: Brain & Development - September 5, 2007 Category: Neurology Authors: You SJ, Kang HC, Ko TS, Kim HD, Yum MS, Hwang YS, Lee JK, Kim DS, Park SK Tags: Brain Dev Source Type: journals

Trends in the use of vagus nerve stimulation for epilepsy: analysis of a nationwide database.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Trends from a national database reveal consistent use of VNS for intractable epilepsy. Greater use of the procedure appears to be reflected in the female population, and the procedure has been performed most often at tertiary care teaching hospitals, where a comprehensive evaluation for all forms of therapy is arguably best able to target appropriate patients for appropriate therapies. With the recent application of VNS to target populations without epilepsy, such as patients with refractory depression, the trend of continued use of this treatment for epilepsy appears likely. PMID: 18759611 [PubMed - as supplied by publisher]
Source: Neurosurgical Focus - September 1, 2008 Category: Neurosurgery Authors: Baaj AA, Benbadis SR, Tatum WO, Vale FL Tags: Neurosurg Focus Source Type: journals

New Peer-Reviewed Publication Authored By Leading Scientists Provides Comprehensive Review of VNS Therapy Mechanism of Action in Treatment-Resistant DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HOUSTON, July 5 /PRNewswire-FirstCall/ -- Cyberonics, Inc. (NASDAQ:CYBX) today announced publication in the July 2006 issue of Neuropsychopharmacology (Neuropsychopharmacology 2006;31:1345-1355) of a peer-reviewed review article summarizing the results of a large body of studies that have investigated the mechanism of action of Vagus Nerve Stimulation (VNS) Therapy. The review also...
Source: Drug Newswire - July 7, 2006 Category: Pharmaceuticals Source Type: news

Vagus nerve stimulation induces changes in respiratory sinus arrhythmia of epileptic children during sleepEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Together with disorders of respiration, cardiac activity, and oxygen saturation (SaO2) described previously. VNS also modifies synchronization between cardiac and respiratory activity, resulting in poor optimization of oxygen delivery to tissues that can be regarded as an additive side effect, which should be considered in patients with already altered brain function. This interaction between the effects of VNS and potential autonomic nervous system (ANS) dysfunction already reported in epileptic patients should be considered to be potentially life-threatening. In addition, evaluation of changes in respiratory ...
Source: Epilepsia - July 20, 2009 Category: Neurology Authors: Boubker Zaaimi, Reinhard Grebe, Patrick Berquin, Fabrice Wallois Source Type: journals

Vagus nerve stimulation acutely alters food craving in adults with depression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vagus nerve stimulation (VNS) is now available as a treatment for epilepsy and treatment-resistant depression. The vagus nerve plays a central role in satiety and short-term regulation of food intake and research suggests a relationship between VNS and weight loss. The underlying mechanisms of this relationship are unknown. The purpose of the current study was to determine whether acute cervical VNS might temporarily alter food cravings. Thirty-three participants were recruited for three groups; depression VNS, depression non-VNS, and healthy controls. Participants viewed 22 computerized images of foods twice in one se...
Source: Appetite - February 19, 2007 Category: Nutrition Authors: Bodenlos JS, Kose S, Borckardt JJ, Nahas Z, Shaw D, O'neil PM, George MS Tags: Appetite Source Type: journals

Relationship between right cervical vagus nerve stimulation and atrial fibrillation inducibility: therapeutic intensities do not increase arrhythmogenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: AF inducibility by right cervical VNS is intensity dependent: strong VNS (producing > or =60% SCL prolongation) facilitates AF, while moderate VNS (producing < or =40% SCL prolongation) appears not to affect AF. The nonarrhythmogenic effect of therapeutic chronic VNS was further verified in conscious animals. We conclude that VNS with moderate intensities can be used to deliver therapeutic benefits without arrhythmogenic risk. PMID: 19187919 [PubMed - in process]
Source: Heart Rhythm - February 1, 2009 Category: Cardiology Authors: Zhang Y, Ilsar I, Sabbah HN, Ben David T, Mazgalev TN Tags: Heart Rhythm Source Type: journals

Improved Mood and Remission of Symptoms in Long-term Major Depression Using Vagus Nerve StimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The study reports results seen with a patient, including her response to traditional antidepressants and the positive results seen using vagus nerve stimulation therapy. Medscape General Medicine
Source: Medscape Pharmacist Headlines - December 20, 2007 Category: Drugs & Pharmacology Tags: Internal Medicine Source Type: info

Right-sided vagus nerve stimulation inhibits induced spinal cord seizuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have previously shown that left-sided vagus nerve stimulation results in cessation of induced spinal cord seizures. To test our hypothesis that right-sided vagus nerve stimulation will also abort seizure activity, we have initiated seizures in the spinal cord and then performed right-sided vagus nerve stimulation in an animal model. Four pigs were anesthetized and placed in the lateral position and a small laminectomy performed in the lumbar region. Topical penicillin, a known epileptogenic drug to the cerebral cortex and spinal cord, was next applied to the dorsal surface of the exposed cord. With the exception of the ...
Source: Clinical Anatomy - September 21, 2006 Category: Anatomy Authors: R. Shane Tubbs, E. George Salter, Cheryl Killingsworth, Dennis L. Rollins, William M. Smith, Raymond E. Ideker, John C. Wellons III, Jeffrey P. Blount, W. Jerry Oakes Source Type: journals

BOLD fMRI deactivation of limbic and temporal brain structures and mood enhancing effect by transcutaneous vagus nerve stimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Our study shows the feasibility and beneficial effects of transcutaneous nerve stimulation in the left auditory canal of healthy subjects. Brain activation patterns clearly share features with changes observed during invasive vagus nerve stimulation. Content TypeJournal Article JournalJournal of Neural TransmissionOnline ISSN 1435-1463Print ISSN 0300-9564
Source: Journal of Neural Transmission - June 13, 2007 Category: Neurology Tags: Journal of Neural Transmission Source Type: journals

Effects of vagus nerve stimulation on pro- and anti-inflammatory cytokine induction in patients with refractory epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The role of the vagus nerve in controlling and modulating inflammatory responses under physiological conditions has been investigated. The purpose of this study is to assess changes in the immunological state evoked by vagus nerve stimulation in humans, by measuring cytokines produced by peripheral blood mononuclear cells (PBMC).We compared induction of IL-1β, IL-6, IL-8, IL-10 and TNF-α by lipopolysaccharide (LPS)-stimulated PBMC which were isolated from patients treated with vagus nerve stimulation for refractory epilepsy. We observed a significant decrease in IL-8 induction by LPS-stimulated PBMC after 6mont...
Source: Journal of Neuroimmunology - July 16, 2009 Category: Allergy & Immunology Authors: Veerle De Herdt, Sara Bogaert, Ken R. Bracke, Robrecht Raedt, Martine De Vos, Kristl Vonck, Paul Boon Tags: Clinical Neuroimmunology Source Type: journals

Vagus nerve stimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
— Overview covers definition, risks, results of this procedure to treat depressionSponsored by:Chemotherapy.com - http://www.chemotherapy.com
Source: MayoClinic.com Full Feed - July 31, 2008 Category: Consumer Health News Source Type: news

Vagus nerve stimulation effective for rapid-cycling bipolar disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vagus nerve stimulation is an efficacious and well-tolerated therapy for patients with treatment-resistant rapid-cycling bipolar disorder, results of a 12-month pilot study show.
Source: MedWire News - Psychiatry - March 6, 2008 Category: Psychiatry Source Type: news

Preservation of a subcutaneous pocket for vagus nerve stimulation pulse generator during magnetoencephalography. Technical note.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with epilepsy and an implanted vagus nerve stimulation (VNS) device who are referred for consideration of definitive epilepsy surgery (removal of the epileptogenic cortex) may require magnetoencephalography (MEG), a study requiring explantation of the pulse generator, as part of their evaluation. Nonetheless, these patients may not wish to abandon palliative VNS therapy should definitive surgery prove unsuccessful or impossible. To avoid obliteration of the pocket by scar tissue after the pulse generator is explanted, the authors have preserved the dead space in several patients with insertion of a similarly s...
Source: Journal of Neurosurgery - December 1, 2007 Category: Neurosurgery Authors: Donahue D, Sanchez R, Hernandez A, Malik S, Black CT, Honeycutt J Tags: J Neurosurg Source Type: journals

Cyberonics Announces Patient Enrollment In New TRD Dosing StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cyberonics, Inc. (Nasdaq: CYBX) today announced that the first nine patients have been enrolled in a year-long Vagus Nerve Stimulation (VNS) Therapy dosing study that will examine treatment outcomes for patients with treatment-resistant depression (TRD) who are randomized to three different doses of VNS Therapy.Approximately 460 patients at 30 study sites will be enrolled in themulti-center, double-blind, randomized study. [click link for full article]
Source: Bipolar News From Medical News Today - May 18, 2006 Category: Psychiatry Source Type: news