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1969 records returned

Algorithm for correcting optimization convergence errors in Eclipse.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IMRT plans generated in Eclipse use a Dose Volume Optimizer (DVO) algorithm to evaluate dose for optimization and a more accurate algorithm for a final Volume Dose (VD) calculation, the Analytical Anisotropic Algorithm (AAA). The use of the DVO introduces Optimization Convergence Errors (OCE's) into an IMRT plan. Eclipse has a feature where optimization may be performed on top of an existing base plan. When the base plan is an optimized IMRT plan, a second optimization can compensate for errors in the base plan. Errors in the base plan are demonstrated to originate in the DVO. An IMRT plan containing the same field arr...
Source: Journal of Applied Clinical Medical Physics - November 20, 2009 Category: Physics Authors: Zacarias AS, Mills MD Tags: J Appl Clin Med Phys Source Type: journals

Branched Endograft for Aortoiliac Artery Aneurysms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Iliac aneurysms can occur concomitantly in 15 to 20% of abdominal aortic aneurysms. The common iliac arteries serve as the distal landing zones for the iliac limbs of abdominal aortic stent grafts, and for most currently available devices, the maximum treatable iliac size is 20 mm. When the iliac artery diameter exceeds this, alternative landing zones or adjunctive techniques are required to achieve an adequate distal seal and fixation, which typically involves occlusion of the hypogastric artery origin and extension to the external iliac artery. The clinical sequelae of acute hypogastric occlusion mostly involve sympt...
Source: Vascular - November 19, 2009 Category: Surgery Authors: Lee WA Tags: Vascular Source Type: journals

Clinical trials update from the European Society of Cardiology Meeting 2009: AAA, RELY, PROTECT, ACTIVE-I, European CRT survey, German pre-SCD II registry, and MADIT-CRTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides information and a commentary on trials relevant to the pathophysiology, prevention, and treatment of heart failure presented at the annual meeting of the European Society of Cardiology held in Barcelona in 2009. The AAA study does not support the routine use of aspirin for the prevention of vascular events in patients with asymptomatic atherosclerosis. RELY suggests that dabigatran may be more effective than warfarin for the prevention of stroke in patients with atrial fibrillation. Rolofylline was not superior to placebo in improving outcomes in patients with acute heart failure enrolled in the PROTE...
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Cleland, J. G.F., Coletta, A. P., Yassin, A., Buga, L., Torabi, A., Clark, A. L. Tags: MEETING REPORT Source Type: journals

Gore Announces Availability of the Q50 Stent Graft Balloon CatheterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Balloon Catheter from QXMédical complements GORE EXCLUDER® AAA Endoprosthesis for endovascular aortic repair FLAGSTAFF, Ariz., Nov 18--(HSMN NewsFeed)--W. L. Gore & Associates (Gore) today announced it has entered into a partnership with QXM&... Devices, InterventionalW. L. Gore, QXMédical, Q50, Stent Graft Balloon Catheter, AAA, (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 18, 2009 Category: Pharmaceuticals Source Type: news

Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease [Biophysics_And_Computational_Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ClpXP is an ATP-fueled molecular machine that unfolds and degrades target proteins. ClpX, an AAA+ enzyme, recognizes specific proteins, and... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 17, 2009 Category: Science Authors: Shin, Y., Davis, J. H., Brau, R. R., Martin, A., Kenniston, J. A., Baker, T. A., Sauer, R. T., Lang, M. J. Tags: Biophysics_And_Computational_Biology Source Type: journals

Screening for abdominal aortic aneurysm (AAA) in men 65 to 74 years of age was cost-effective for AAA mortality at 10 years.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19920260 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - November 17, 2009 Category: Internal Medicine Tags: Ann Intern Med Source Type: journals

Micromechanical Characterization of Intra-luminal Thrombus Tissue from Abdominal Aortic Aneurysms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The reliable assessment of Abdominal Aortic Aneurysm rupture risk is critically important in reducing related mortality without unnecessarily increasing the rate of elective repair. Intra-luminal thrombus (ILT) has multiple biomechanical and biochemical impacts on the underlying aneurysm wall and thrombus failure might be linked to aneurysm rupture. Histological slices from 7 ILTs were analyzed using a sequence of automatic image processing and feature analyzing steps. Derived microstructural data was used to define Representative Volume Elements (RVE), which in turn allowed the estimation of microscopic material prope...
Source: Annals of Biomedical Engineering - November 17, 2009 Category: Biomedical Engineering Authors: Gasser TC, Martufi G, Auer M, Folkesson M, Swedenborg J Tags: Ann Biomed Eng Source Type: journals

Structures of Asymmetric ClpX Hexamers Reveal Nucleotide-Dependent Motions in a AAA+ Protein-Unfolding MachineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Steven E. Glynn, Andreas Martin, Andrew R. Nager, Tania A. Baker, Robert T. Sauer. ClpX is a AAA+ machine that uses the energy of ATP binding and hydrolysis to unfold native proteins and translocate unfolded polypeptides into the ClpP peptidase. The crystal structures presented .... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals

Advantage of a one-stop referral and management service for ruptured abdominal aortic aneurysmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the referral and management patterns of this condition within one English county.West Sussex has a population of 811 000 and is served by five hospitals with two main vascular networks. Between January 2005 and December 2007, data for community and in-hospital RAAA interventions and deaths were obtained. Probability of intervention and outcome for each network were calculated.Of 341 RAAA, 228 (66·9 per cent) presented to hospital. The mean distance travelled to hospitals with a full on-site vascular service was 17·6 (95 per cent confidence interval 15·5 to 19·7) km (124 patients) compared with 11·0...
Source: British Journal of Surgery - November 13, 2009 Category: Surgery Authors: H. Hafez, L. W. Owen, C. F. K. Lorimer, A. Bajwa Tags: Original Articles Source Type: journals

Co-evolution of multipartite interactions between an extended tmRNA tag and a robust Lon protease in MycoplasmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Messenger RNAs that lack in-frame stop codons promote ribosome stalling and accumulation of aberrant and potentially harmful polypeptides. The SmpB-tmRNA quality control system has evolved to solve problems associated with non-stop mRNAs, by rescuing stalled ribosomes and directing the addition of a peptide tag to the C-termini of the associated proteins, marking them for proteolysis. In Escherichia coli, the ClpXP system is the major contributor to disposal of tmRNA-tagged proteins. We have shown that the AAA+ Lon protease can also degrade tmRNA-tagged proteins, but with much lower efficiency. Here, we present a unique ca...
Source: Molecular Microbiology - November 13, 2009 Category: Microbiology Authors: Zhiyun Ge, A. Wali Karzai Source Type: journals

Advantage of a one-stop referral and management service for ruptured abdominal aortic aneurysms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION:: Patients with RAAA should be offered a one-stop emergency vascular service even if this involves further travel. Such a strategy offers significantly higher chance of intervention and survival from ruptured AAA. Copyright (c) 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. PMID: 19918851 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - November 13, 2009 Category: Surgery Authors: Hafez H, Owen LW, Lorimer CF, Bajwa A Tags: Br J Surg Source Type: journals

Hemorphin 7 Reflects Hemoglobin Proteolysis in Abdominal Aortic Aneurysm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results suggest that circulating H7 peptides may reflect proteolysis of hemoglobin in the aneurysmal intraluminal thrombus and may be used as a biological marker of pathological vascular remodeling. PMID: 19910633 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Dejouvencel T, Féron D, Rossignol P, Sapoval M, Kauffmann C, Piot JM, Michel JB, Fruitier-Arnaudin I, Meilhac O Tags: Arterioscler Thromb Vasc Biol Source Type: journals

B7-H4 gene polymorphisms are associated with sporadic breast cancer in a Chinese Han populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that B7-H4 gene polymorphism may contribute to the sporadic breast cancer risk and prognosis in Chinese Han women. (Source: BMC Cancer)
Source: BMC Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Jie ZhangMingyan ZhangWei JiangLihong WangZhenkun FuDalin LiDa PangDianjun Li Source Type: journals

A 66-Year-Old Man With an Abdominal Aortic Aneurysm: Review of Screening and Treatment [Clinical Crossroads]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ruptured abdominal aortic aneurysm (AAA) is a common cause of death. Abdominal aortic aneurysms tend to be asymptomatic until the time of rupture, which has a mortality rate of greater than 80%. Therefore, elective repair prior to rupture is preferred if life expectancy is reasonable and the risk of rupture outweighs the risk of repair. Mr F, a 66-year-old man with a 5.2-cm AAA, illustrates the issues surrounding monitoring and treating AAA. Risk factors for AAA include older age, male sex, smoking history, and a family history of AAA. Screening for AAA with ultrasound has been shown to prevent rupture, prevent AAA-related...
Source: JAMA - November 10, 2009 Category: Journals (General) Authors: Schermerhorn, M. Tags: Aging/ Geriatrics, Cardiovascular System, Other, Cardiovascular System, Surgery, Surgical Interventions, Cardiovascular/ Cardiothoracic Surgery, Vascular Surgery Clinical Crossroads Source Type: journals

Three Dimensional Active Contours for the Reconstruction of Abdominal Aortic Aneurysms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we describe a technique to reconstruct AAA geometry from CT images in an inexpensive and streamlined fashion. A 3D reconstruction technique was implemented with a GUI interface in MATLAB using the active contours technique. The lumen and the thrombus of the AAA were segmented individually in two separate protocols and were then joined together into a hybrid surface. This surface was then used to obtain the aortic wall. This method can deal with very poor contrast images where the aortic wall is indistinguishable from the surrounding features. Data obtained from the segmentation of image sets were smoothed in...
Source: Annals of Biomedical Engineering - November 10, 2009 Category: Biomedical Engineering Authors: Ayyalasomayajula A, Polk A, Basudhar A, Missoum S, Nissim L, Vande Geest JP Tags: Ann Biomed Eng Source Type: journals

Critical roles of T-LAK cell-originated protein kinase in cytokinesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We previously reported up-regulation of T-LAK cell-originated protein kinase (TOPK), a novel mitotic kinase, in the great majority of breast cancers. Here we report its critical roles in mitosis, especially in cytokinesis. We found that protein phosphatase 1 alpha (PP1[alpha]) inactivation by cyclin-dependent kinase 1 (CDK1)/cyclin B1 caused enhancement of autophosphorylation of TOPK and resulted in its activation at an early stage of mitosis. Then TOPK interacted with and phosphorylated p97, a member of the AAA+ family of ATPase proteins, through an interaction with p47 protein as an adaptor protein. Interestingly, knockd...
Source: Cancer Science - November 9, 2009 Category: Cancer & Oncology Authors: Jae-Hyun Park, Toshihiko Nishidate, Yusuke Nakamura, Toyomasa Katagiri Source Type: journals

The Role of Geometric Parameters in the Prediction of Abdominal Aortic Aneurysm Wall Stress.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Specific geometric parameters in AAA models in the presence of ILT could serve as potential predictors of elevated PWS. PWS correlated significantly with the maximum diameter and the degree of centreline tortuosity. Centreline tortuosity may become a useful addition to maximum diameter in the decision-making process of AAA treatment. PMID: 19906549 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - November 9, 2009 Category: Surgery Authors: Georgakarakos E, Ioannou CV, Kamarianakis Y, Papaharilaou Y, Kostas T, Manousaki E, Katsamouris AN Tags: Eur J Vasc Endovasc Surg Source Type: journals

Intra-aneurysm Sac Pressure in Patients with Unchanged AAA Diameter after EVAR.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: AAAs without endoleak and unchanged diameter more than 1 year after EVAR will often continue unchanged. Expansion can eventually occur in the absence of intra-sac fluid accumulation and is associated with higher and more pulsatile intra-sac pressure. However, in patients with intra-sac fluid, expansion can occur with low intra-sac pressures. PMID: 19906545 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - November 9, 2009 Category: Surgery Authors: Dias NV, Ivancev K, Kölbel T, Resch T, Malina M, Sonesson B Tags: Eur J Vasc Endovasc Surg Source Type: journals

[Abdominal aorta aneuyrsms - endovascular and open surgery.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background. In Norway, repair of abdominal aortic aneurysms is performed in more than 800 patients annually. Open repair is an established procedure, but an increasing number of patients have undergone endovascular repair during the last decades. The paper delivers an up to date discussion of infrarenal abdominal aortic aneurysm repair. Materials and methods. A systematic search was performed in Pubmed and literature containing the search terms <<abdominal aortic aneurysm>> and <<mortality>> (from 2004 to 2009) was retrieved. The review is based on randomized, multi-centre and registry studies e...
Source: Tidsskrift for den Norske Laegeforening - November 5, 2009 Category: Journals (General) Authors: Vetrhus M, Viddal B, Loose H, Neverdal NO, Nordang E Tags: Tidsskr Nor Laegeforen Source Type: journals

Routine Screening for Asymptomatic Abdominal Aortic Aneurysm in High-risk Patients Is Not Recommended in Emergency Departments That Are Frequently CrowdedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Routine screening for asymptomatic AAA required substantial ED resources for a relatively low success rate of completed screens. The prevalence rate of AAA in our ED sample was not significantly different than prevalence estimates obtained from older men in the general population. ED sonographers reported benefits of screening in terms of improving the quality of emergency care and patient satisfaction, but also reported that it reduced operational efficiency. For EDs that have problems with crowding, we do not recommend implementing a routine screening program for AAA, even among high-risk patients. ACADEMIC ...
Source: Academic Emergency Medicine - November 4, 2009 Category: Emergency Medicine Authors: Beatrice Hoffmann, Patrick Um, Edward S. Bessman, Ru Ding, Gabor D. Kelen, Melissa L. McCarthy Tags: Original Contributions Source Type: journals

Efficacy of TachoSil patches in controlling Dacron suture-hole bleeding after abdominal aortic aneurysm open repairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose.The aim of this study is evaluate the efficacy of TachoSil patches in controlling suture-hole bleeding after elective infrarenal abdominal aortic aneurysm (AAA) replacement with Dacron graft.Materials and Methods.Patients undergoing elective replacement of infrarenal AAA with Dacron grafts were prospectively randomized to TachoSil patches (Group I) or standard compression with surgical swabs (Group II). We evaluated time to haemostasis, blood loss during the operation, blood loss after cross-clamp removal, duration of operation, drain volume, requirement for blood transfusion and surgeons rating of efficacy. Result...
Source: BioMed Central - November 4, 2009 Category: Journals (General) Authors: Guido BajardiFelice PecoraroDomenico Mirabella Source Type: journals

Accounting for near-normal glucose sensitivity in Kir6.2[AAA] transgenic mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
K(ir)6.2[AAA] transgenic mouse islets exhibit mosaicism such that approximately 70% of the beta-cells have nonfunctional ATP-sensitive potassium (K(ATP)) channels, whereas the remainder have normal K(ATP) function. Despite this drastic reduction, the glucose dose-response curve is only shifted by approximately 2 mM. We use a previously published mathematical model, in which K(ATP) conductance is increased by rises in cytosolic calcium through indirect effects on metabolism, to investigate how cells could compensate for the loss of K(ATP) conductance. Compensation is favored by the assumption that only a small fraction ...
Source: Biophysical Journal - November 4, 2009 Category: Physics Authors: Tsaneva-Atanasova K, Sherman A Tags: Biophys J Source Type: journals

Contrast in usage of FCAT-approved anatomical terminology between members of two anatomy associations in North AmericaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Almost 12 years since the publishing of Terminologia Anatomica (TA) by the Federative Committee on Anatomical Terminology (FCAT), there has yet to be a unified adoption of FCAT-recommended anatomical terms by North American anatomists. A survey was sent to members of the Human Anatomy & Physiology Society (HAPS) to compare the frequency of FCAT term usage with a previous study involving the American Association of Anatomists (AAA). The HAPS differed from AAA in being composed mostly of biologists (56.5%) who teach anatomy with only 18.3% of respondents having terminal degrees in anatomy. The survey included the same 25 set...
Source: Anatomical Sciences Education - November 4, 2009 Category: Anatomy Authors: Bradford D. Martin, Donna Thorpe, Victoria Merenda, Brian Finch, Wendy Anderson-Smith, Zane Consiglio-Lahti Source Type: journals

Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine [Biochemistry]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AAA+ proteases are ATP-fueled machines that bind protein substrates via a degradation tag, unfold the molecule if necessary, and then... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 3, 2009 Category: Science Authors: Gur, E., Sauer, R. T. Tags: Biochemistry Source Type: journals

First Device Designed to Preserve Blood Flow to Iliac Arteries During Aneurysm Repair Receives Approval from Health CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Minimally Invasive Treatment for Aortic Disease Is Safe, Effective Alternative to Open Surgery BLOOMINGTON, Ind.--(HSMN NewsFeed)--Canadian physicians can now treat patients suffering from life-threatening aneurysms in one of the bodys largest arteries... Devices, Interventional, RegulatoryCook Medical, Endovascular Graft, abdominal aortic aneurysm, iliac artery (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 3, 2009 Category: Pharmaceuticals Source Type: news

Management of Hyperlipidemia in Patients With Abdominal Aortic Aneurysm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19884630 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - November 3, 2009 Category: Internal Medicine Authors: Sethi A Tags: Ann Intern Med Source Type: journals

The incidence of epidural abscess following epidural analgesia in open abdominal aortic aneurysm repair.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS The incidence of epidural abscess following epidural analgesia in patients undergoing open AAA repair withinour department was 0.48%. Although a rare complication, epidural abscess can cause significant morbidity. Epidural abscessesrarely develop before the third postoperative day. PMID: 19887020 [PubMed - as supplied by publisher] (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - November 2, 2009 Category: Surgery Authors: Wallace D, Bright E, London N Tags: Ann R Coll Surg Engl Source Type: journals

Endovascular aneurysm repair is associated with less malnutrition than open abdominal aortic aneurysm repairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients undergoing EVAR developed significantly less postoperative malnutrition compared with those having open repair. EVAR may be a strategy to avoid malnutrition and improve outcomes in patients at risk for malnutrition after undergoing AAA repair. (Source: American Journal of Surgery)
Source: American Journal of Surgery - November 1, 2009 Category: Surgery Authors: Cassius Iyad Ochoa Chaar, Tamara N. Fitzgerald, Michael Dewan, Matthew Huddle, Felix J. Schlosser, Melissa Perkal, Bart E. Muhs, Alan Dardik Tags: The Association of VA Surgeons Source Type: journals

Screening for abdominal aortic aneurysm with electronic clinical remindersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Recognition of newly diagnosed AAA compared favorably with that of previous screening studies. Electronic clinical reminders identify undiagnosed, life-threatening AAAs before rupture. Immediate counseling is available in the vascular setting. (Source: American Journal of Surgery)
Source: American Journal of Surgery - November 1, 2009 Category: Surgery Authors: Frank T. Padberg, Karen Hauck, Richard G. Mercer, B.K. Lal, Peter J. Pappas Tags: The Association of VA Surgeons Source Type: journals

Anthropometric and Performance Comparisons in Professional Baseball PlayersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study compared anthropometric and performance variables in professional baseball players and examined the relationship between these variables and baseball-specific performance (i.e., home runs, total bases, slugging percentage, and stolen bases). During a 2-year period, 343 professional baseball players were assessed for height, weight, body composition, grip strength, vertical jump power, 10-yard sprint speed, and agility. Subject population consisted of players on the rosters of one of the minor league affiliates (Rookie, A, AA, AAA) or major league team (MLB). All testing occurred at the beginning of spring traini...
Source: Journal of Strength and Conditioning Research - November 1, 2009 Category: Sports Medicine Tags: Original Research Source Type: journals

Diastasis recti and abdominal aortic aneurysm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An association between abdominal aortic aneurysm (AAA) and abdominal wall hernia has been suggested, possibly reflecting a common collagen disorder. The same mechanism may also cause a greater frequency of diastasis recti among patients at risk of developing AAA. Diastasis recti could be used to identify patients at risk of AAA, with implications for AAA screening. The aim of this study was to determine whether an association between diastasis recti and AAA could be demonstrated.The preoperative computed tomographic (CT) scans of 75 male patients undergoing elective AAA repair were retrospectively examined and linea al...
Source: Vascular - November 1, 2009 Category: Surgery Authors: Moesbergen T, Law A, Roake J, Lewis DR Tags: Vascular Source Type: journals

Patients with abdominal aortic aneurysm and chronic obstructive pulmonary disease have improved outcomes with endovascular aneurysm repair compared with open repair.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of our study was to evaluate outcomes in abdominal aortic aneurysm (AAA) patients with chronic obstructive pulmonary disease (COPD) undergoing open or endovascular abdominal aortic aneurysm repair (EVAR). We retrospectively examined the records of consecutive patients with AAA and COPD who underwent either open repair or EVAR between 2001 and 2008. In-hospital and follow-up outcomes were compared between open repair and EVAR using SPSS (SPSS Inc, Chicago, IL). Sixty-nine patients were included for analysis (mean age 71 +/- 1.0 years; 93% [n = 64] male). Open surgery was performed in 63% (n = 43). In-hospita...
Source: Vascular - November 1, 2009 Category: Surgery Authors: Jonker FH, Schlösser FJ, Dewan M, Huddle M, Sergi M, Dardik A, Muhs BE Tags: Vascular Source Type: journals

Delayed abdominal closure in the management of ruptured abdominal aortic aneurysm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to compare initial use of the open abdomen using the vacuum-pack technique followed by delayed abdominal closure with standard primary abdominal closure in the treatment of ruptured abdominal aortic aneurysm (rAAA) repair. A retrospective review identified 122 rAAA cases, which were divided into two management eras: era 1 (primarily closed) and era 2 (47% open abdomen).One hundred three patients were included in this review: 58 in era 1 and 45 in era 2. Evidence of one of three ischemia-reperfusion (IR) criteria, preoperative hypotension, estimated blood loss >/= 6 L, or intraoperative re...
Source: Vascular - November 1, 2009 Category: Surgery Authors: Kimball EJ, Adams DM, Kinikini DV, Mone MC, Alder SC Tags: Vascular Source Type: journals

Endovascular repair of ruptured abdominal aortic aneurysms in a rural center is both feasible and associated with reduced blood product requirements.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endovascular aneurysm repair (EVAR) of ruptured abdominal aortic aneurysm (rAAA) has been shown to be both feasible and associated with a reduced operative mortality when compared with conventional open repair (OR). The aim of this study was to show the feasibility of EVAR of rAAA in a rural vascular unit and to investigate the blood product requirements when compared to OR. The method used in this study was a retrospective case note review of patients presenting with rAAA to a small, rural vascular unit between February 2004 and November 2008. Admission demographics and hematological variables were recorded. Volumes o...
Source: Vascular - November 1, 2009 Category: Surgery Authors: Vun S, Walker SR Tags: Vascular Source Type: journals

Regarding “Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with interest the study by Elmore and colleagues, which reported an association between a region on chromosome 3 and abdominal aortic aneurysm (AAA). We were intrigued to see if this association was also present in our New Zealand AAA cohort. An in silico validation was performed using 567 cases and 552 screened controls that have been genotyped using Affymetrix Genome-Wide Human SNP Array 6.0. We could not replicate the reported association with rs7635818. Nor was there any association with neighboring SNPs. Nevertheless, we also examined SNPs in the region of CNTN3, the nearest gene to the locus identified by Elm...
Source: Journal of Vascular Surgery - October 30, 2009 Category: Surgery Authors: Gregory T. Jones, André M. van Rij Tags: Letters to the editor Source Type: journals

ReplyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We thank the investigators for their interest in our paper, and would like to make several points regarding their observations. First, their sample size is underpowered for a replication study of the reported association. For an association with an odds ratio of 1.3 and minor allele frequency of 0.4, the statistical power is 0.45 (based on an allelic genetic model) at α = 0.05. Therefore, the failure to replicate the association is not conclusive. Second, the investigators do report a statistically significant association with single nucleotide polymorphisms (SNP) in intron 2 of the CNTN3 gene. This supports our working h...
Source: Journal of Vascular Surgery - October 30, 2009 Category: Surgery Authors: James R. Elmore, Melissa A. Obmann, Helena Kuivaniemi, Gerard Tromp, Glenn S. Gerhard, David P. Franklin, David J. Carey, Amy M. Boddy Tags: Letters to the editor Source Type: journals

The Visceral Hybrid Repair of Thoraco-abdominal Aortic Aneurysms – A Collaborative ApproachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: To report the collaborative data of 3 major European Vascular Units using the ‘visceral hybrid' procedure for thoraco-abdominal aortic aneurysms and dissections. Methods: A consecutive series of 107 urgent and elective high-risk patients were included in a prospectively collected database. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - October 30, 2009 Category: Surgery Authors: S.L. Drinkwater, D. Böckler, H. Eckstein, N.J.W. Cheshire, D. Kotelis, O. Wolf, M.S. Hamady, P. Geisbüsch, M. Clark, J.R. Allenberg, J.H. Wolfe, R.G. Gibbs, M.P. Jenkins Tags: Selected abstracts from the November issue of the European Journal of Vascular and Endovascular Surgery Source Type: journals

Regarding “Prediction of 30-day mortality after endovascular repair or open surgery in patients with ruptured abdominal aortic aneurysms”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with interest the article by Dr Visser and colleagues. The Glasgow Aneurysm Score (GAS) was described in 1994 as a tool for prognostic scoring in patients undergoing open repair of either intact or ruptured abdominal aortic aneurysm (AAA). A retrospective, multicentred, nonconsecutive sample of 500 patients undergoing aneurysm repair at general surgical units in Glasgow between 1980 and 1990 was examined for risk factors associated with death. Recently, this risk-scoring instrument has been the subject of external validation. When applied to our own series' of both retrospective and prospective data on patients un...
Source: Journal of Vascular Surgery - October 30, 2009 Category: Surgery Authors: Elaine Yeap, Andrew L. Tambyraja, Roderick T.A. Chalmers Tags: Letters to the editor Source Type: journals

Laparoscopic-assisted treatment of abdominal aortic aneurysm requiring suprarenal cross-clampingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The HALS technique proved to be feasible and safe not only for patients with IAAA, but also for the management of patients with JAAA. No significant difference could be shown in the comparison between the two groups, apart from the expected higher rate of postoperative renal dysfunction after suprarenal clamping. In view of the demonstrated benefit of this minimally invasive approach, we believe that it should be included among the alternative options of treatment for these patients. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - October 30, 2009 Category: Surgery Authors: Mauro Ferrari, Daniele Adami, Raffaella Berchiolli, Andrea Del Corso, Andrea Pietrabissa Tags: Clinical research studies Source Type: journals

Spectrum of PEX6 mutations in Zellweger syndrome spectrum patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The autosomal recessive Zellweger syndrome spectrum (ZSS) disorders comprise a main subgroup of the peroxisome biogenesis disorders. The ZSS disorders can be caused by mutations in any of 12 different currently identified PEX genes resulting in severe, often lethal, multi-systemic disorders. Defects in the PEX6 gene are the second most common cause for ZSS disorders. The encoded protein PEX6 belongs to the AAA ATPase family and contains two AAA cassettes and an AAA protein family signature. The PEX6 gene consists of 17 exons and previously mutations in the PEX6 gene were found to be scattered over all exons. We developed a...
Source: Human Mutation - October 30, 2009 Category: Genetics & Stem Cells Authors: Merel S. Ebberink, Janet Kofster, Ronald J.A. Wanders, Hans R. Waterham Source Type: journals

Purification, crystallization and preliminary X-ray diffraction analysis of disease-related mutants of p97Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The human type II AAA+ protein p97 participates in various cellular activities, presumably through its involvement in the ubiquitin–proteasome degradation pathway. Mutations in p97 have been implicated in patients with inclusion-body myopathy associated with Paget's disease of the bone and frontotemporal dementia (IBMPFD). In this work, three mutant p97 N-D1 fragments, R86A, R95G and R155H, were crystallized in the presence of ATPγS with PEG 3350 as a main precipitant, yielding two different crystal forms. The R155H mutant crystal belonged to space group R3, with unit-cell parameters in the hexagonal setting of a = b = ...
Source: Acta Crystallographica Section F - October 30, 2009 Category: Biochemistry Authors: Tang, W.-K.Li, D.Esser, L.Xia, D. Tags: p97 AAA proteins disease-related mutants crystallization communications Source Type: journals

Re-interventions, Readmissions and Discharge Destination: Modern Metrics for the Assessment of the Quality of Care.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Administrative data can be used to identify metrics other than mortality and length of stay. These metrics might be used to inform service provision. In particular for AAA repair, differences in these outcomes were identified between open repair and EVAR and between octogenarians and younger patients. PMID: 19879782 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - October 29, 2009 Category: Surgery Authors: Holt PJ, Poloniecki JD, Hofman D, Hinchliffe RJ, Loftus IM, Thompson MM Tags: Eur J Vasc Endovasc Surg Source Type: journals

The Influence of Different Types of Stent Grafts on Aneurysm Neck Dynamics after Endovascular Aneurysm Repair.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The aorta expands significantly and asymmetrically throughout the cardiac cycle. After implantation of abdominal aortic stent grafts, the aortic distension and direction of distension remain equally preserved in all three groups. The three stent graft types studied seem to be able to adapt to the asymmetric dynamic aortic shape changes. PMID: 19879781 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - October 29, 2009 Category: Surgery Authors: van Keulen JW, Vincken KL, van Prehn J, Tolenaar JL, Bartels LW, Viergever MA, Moll FL, van Herwaarden JA Tags: Eur J Vasc Endovasc Surg Source Type: journals

Paddling mechanism for the substrate translocation by AAA+ motor revealed by multiscale molecular simulations [Biophysics_And_Computational_Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hexameric ring-shaped AAA+ molecular motors have a key function of active translocation of a macromolecular chain through the central pore.... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - October 27, 2009 Category: Science Authors: Koga, N., Kameda, T., Okazaki, K.-i., Takada, S. Tags: Biophysics_And_Computational_Biology Source Type: journals

Severe Acute Pancreatitis after Surgical Treatment of a Ruptured Abdominal Aortic AneurysmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of severe AP after surgical treatment of a ruptured abdominal aorta aneurysm and discuss its etiopathogenic mechanisms. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - October 27, 2009 Category: Surgery Authors: Mohammed Drissi, Mouhcine Madani, Abeddayem Hatim, Driss Ibat, Mohammed Athmani, Mustapha Taberkant, Mehdi Ait Houssa, Mustapha Alaoui, A. Boulahya Tags: Case Report Abstracts Source Type: journals

Laparoscopic Aortic Surgery in Obese PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Obesity is not an operative risk factor for laparoscopic aortic surgery. Our results confirm its feasibility and durability for this high-risk population. Laparoscopy should be considered as the technique of choice whenever direct AAA repair is planned in obese patients. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - October 27, 2009 Category: Surgery Authors: Raphaël Coscas, Marc Coggia, Isabelle Di Centa, Isabelle Javerliat, Frederic Cochennec, Olivier Goëau-Brissonniere Tags: Papers Presented to the French Society for Vascular Surgery Source Type: journals

Acute thrombosis of abdominal aortic aneurysm during cardiac surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a unique case of thrombosis of an abdominal aortic aneurysms during the course of cardiac surgery, in a fully anticoagulated patient on cardiopulmonary bypass. Prompt diagnosis and immediate surgical management were critical for a successful outcome. PMID: 19853134 [PubMed - in process] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 27, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Haddad F, Yazigi A, El-Rassi I, Madi-Jebara S, Jabbour K, Jebara V, Al Ayle N Tags: Ann Thorac Surg Source Type: journals

Addressing Health Disparities Among African Americans: Using the Stages of Change Model to Document Attitudes and Decisions About Nutrition and Physical ActivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Physical activity (PA) and poor fruit/vegetable intake are contributors of health disparities among African Americans (AA). In order to design effective interventions to address these behaviors, it is essential to assess where individuals are in terms of their attitudes and decisions. The aim of this study was to use the Stages of Change Model to assess AA’s attitudes and decisions regarding pertinent health behaviors and provide suggestions about how to address them. A survey was administered to 242 low-income, medically underserved adults (47% AA, 27% White, and 26% “Others”). The majority w...
Source: Journal of Community Health - October 24, 2009 Category: Global & Universal Tags: Journal of Community Health Source Type: journals

Infected abdominal aortic aneurysm caused by nontyphoid Salmonella in an immunocompromised patient with rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Nontyphoid Salmonella strains are important pathogens commonly found worldwide, typically causing gastrointestinal illness. Here, we report a case of a 66-yearold man with an abdominal aortic infected (or so-called mycotic) aneurysm caused by Salmonella enterica subsp. enterica serovar Enteritidis (S. Enteritidis). He had multiple risk factors for atherosclerosis: age over 60, a long history of smoking, an 8-year history of diabetes mellitus, and a 10-year history of rheumatoid arthritis treated with low-dose corticosteroids. Although he had presented with no episode of diarrhea or abdominal pain, th...
Source: Journal of Infection and Chemotherapy - October 24, 2009 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: journals

Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the behaviour of meiotic mouse HORMA-domain proteins—HORMAD1 and HORMAD2—in wild-type and meiotic mutants. HORMAD1/2 preferentially accumulate on unsynapsed chromosome axes. Our data suggest that HORMAD1/2 depletion from chromosomes is a response to synaptonemal complex formation and it that is a conserved process supported by TRIP13/Pch2 AAA-ATPase. Assuming that HORMA-domain functions are conserved in mammals, we speculate that depletion of HORMADs from axes might contribute to the down-regulation of inter-homologue bias and the prophase checkpoint once homology search is completed and synaptonemal comple...
Source: PLoS Genetics - October 22, 2009 Category: Genetics & Stem Cells Authors: Lukasz Wojtasz et al. Source Type: journals