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Vincristine-Induced Unilateral Ptosis in a ChildEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vincristine is a vinca alkaloid used in combination with other agents in the treatment of solid tumors, lymphoma, and leukemia, as well as for idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia. A dose-limiting complication of vinca alkaloids is neurotoxicity. Vincristine is the oldest and also the most neurotoxic agent in this group. Described here is the case of a 4-year-old girl with unilateral palpebral ptosis. She has been diagnosed with precursor B-cell acute lymphoblastic leukemia. Ptosis was noted on the 45th day of therapy, and the last vincristine was administered on the 28th day of protocol 1. V...
Source: Pediatric Neurology - November 20, 2009 Category: Neurology Authors: Orhan Gursel, Erkan Sari, Demet Altun, A. Avni Atay, Ridvan Akin Tags: Case Reports Source Type: journals

Diagnosis of biphenotypic acute leukemia: a paradigmatic approach.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biphenotypic acute leukemia (BAL), or acute leukemia with a single population of blasts coexpressing markers of two different lineages, is a rare clinical entity. To define BAL, a scoring system was proposed by the European Group of Immunological Markers for Leukemias (EGIL) in 1995. However, increasing evidence suggests that this system has limitations, as acknowledged by the 2008 World Health Organization (WHO) Classification of Tumors of Hematopoietic and Lymphoid Tissues. Although substantially improved in relation to the EGIL, the new WHO Classification is still not optimal for guiding the clinical management of p...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Zhao XF, Gojo I, York T, Ning Y, Baer MR Tags: Int J Clin Exp Pathol Source Type: journals

AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of childhood acute lymphoblastic leukemia (ALL) with both acute myeloid leukemia 1 (AML1) amplification and 17q25 deletion. AML1 gene is located on 21q22 and encodes a transcription factor. AML1 amplification is a common finding in childhood ALL, and itis observed as an increase in gene copy number by the FISH analysis. The mechanism of AML1 amplification is not associated with AML1 gene mutations. The 17q25 is a gene-rich chromosomal location and distinct abnormalities of this region have been observed in previous cases of different kinds of leukemia. Deletion of the 17q25 region has been reported in two ...
Source: Journal of Clinical Laboratory Analysis - November 19, 2009 Category: Laboratory Medicine Authors: Tuna Gulten, Tahsin Yakut, Mutlu Karkucak, Birol Baytan, Adalet Meral Gune[scedil] Tags: Original Articles Source Type: journals

Expression of interleukin 15 in primary adult acute lymphoblastic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Interleukin-15 (IL-15) has been associated with the growth, survival and biological behavior of leukemic cells and response to therapy. We determined the expression of IL-15 in lymphoblasts and evaluated its potential impact on the outcome in adult acute lymphoblastic leukemia (ALL).Between June 1999 and June 2006, ALL samples were collected from 87 adult patients before initiation of antineoplastic therapy. These patients were enrolled in the German Multicenter Acute Lymphoblastic Leukemia June 1999 and July 2003 study trials. The expression of IL-15 in leukemic cells was analyzed by real-time polymerase chain reaction.Th...
Source: Cancer - November 18, 2009 Category: Cancer & Oncology Authors: Shuling Wu, Lars Fischer, Nicola Gökbuget, Stefan Schwartz, Thomas Burmeister, Michael Notter, Dieter Hoelzer, Hendrik Fuchs, Igor Wolfgang Blau, Wolf K Hofmann, Eckhard Thiel Source Type: journals

Structure of Helicobacter pyloril-asparaginase at 1.4 Å resolutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bacterial l-asparaginases have been used in the treatment of childhood acute lymphoblastic leukaemia for over 30 years. Their therapeutic effect is based on their ability to catalyze the conversion of l-asparagine, an essential amino acid in certain tumours, to l-aspartic acid and ammonia. Two l-asparaginases, one from Escherichia coli and the other from Erwinia chrysanthemi, have been widely employed in clinical practice as anti-leukaemia drugs. However, l-asparaginases are also able to cause severe side effects owing to their intrinsic glutaminase activity. Helicobacter pylori l-asparaginase (HpA) has been reported to ...
Source: Acta Crystallographica Section D - November 17, 2009 Category: Biochemistry Authors: Dhavala, P.Papageorgiou, A.C. Tags: l-asparaginases active site leukaemia treatment therapeutic enzymes research papers Source Type: journals

Molecular diagnostics in acute leukemiasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1333-1341 Abstract Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) both represent highly heterogeneous entities on the basis of diverse cyto- and molecular genetic alterations with considerable influence on prognosis and therapeutic decisions. In recent years, insights into the complex network of molecular markers underlying this diversity have shown marked progress due to the detection of novel mutations, such as nucleophosmin gene (NPM1) in AML, and due to the description of cooperation pathways in leukemogenesis. Also, targeted therapeutic strategie...
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Voxel-Based Analysis of T2 Hyperintensities in White Matter during Treatment of Childhood Leukemia [PEDIATRICS]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These analyses identified specific WM tracts involving predominantly the anterior, superior, and posterior corona radiata and superior longitudinal fasciculus, which were at increased risk for the development of T2-weighted hyperintensities during therapy for childhood ALL. These vulnerable regions may be the cause of subsequent cognitive difficulties consistently observed in survivors. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - November 13, 2009 Category: Radiology Authors: Reddick, W.E., Glass, J.O., Johnson, D.P., Laningham, F.H., Pui, C.-H. Tags: PEDIATRICS Source Type: journals

Stage-specific Arf tumor suppression in Notch1-induced T-cell acute lymphoblastic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Frequent hallmarks of T-cell acute lymphoblastic leukemia (T-ALL) include aberrant NOTCH signaling and deletion of the CDKN2A locus, which contains 2 closely linked tumor suppressor genes (INK4A and ARF). When bone marrow cells or thymocytes transduced with a vector encoding the constitutively activated intracellular domain of Notch1 (ICN1) are expanded ex vivo under conditions that support T-cell development, cultured progenitors rapidly induce CD4+/CD8+ T-ALLs after infusion into healthy syngeneic mice. Under these conditions, enforced ICN1 expression also drives formation of T-ALLs in unconditioned CD-1 nude mice, bypas...
Source: Blood - November 12, 2009 Category: Hematology Authors: Volanakis, E. J., Williams, R. T., Sherr, C. J. Tags: Lymphoid Neoplasia Source Type: journals

Gene expression-based classification and regulatory networks of pediatric acute lymphoblastic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pediatric acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Subtype classification can be also achieved through gene expression profiling. However, how to apply such classifiers to a single patient and correctly diagnose the disease subtype in an independent patient group has not been addressed. Furthermore, the underlying regulatory mechanisms responsible for the subtype-specific gene expression patterns are still largely unknown. Here, by combining 3 published microarray datasets on 535 mostly white children's samples and generating a new dataset on...
Source: Blood - November 12, 2009 Category: Hematology Authors: Li, Z., Zhang, W., Wu, M., Zhu, S., Gao, C., Sun, L., Zhang, R., Qiao, N., Xue, H., Hu, Y., Bao, S., Zheng, H., Han, J.-D. J. Tags: Lymphoid Neoplasia Source Type: journals

Experimental protein for leukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study has developed a new method for targeting the NOTCH1 transcription factor. The technique may eventually lead to the development of new drugs for T-ALL and other Notch-related conditions. However, this will be a long-term goal as much more animal and human research will be needed to determine the effectiveness and safety of this new approach. Links To The Headlines Cancer protein 'can be disarmed'. BBC News, November 12 2009 Links To Science Moellering RE, Cornejo M, Davis TN. Direct inhibition of the NOTCH transcription factor complex. Nature 2009; 462: 182-188 (Source: NHS News Feed)
Source: NHS News Feed - November 12, 2009 Category: Consumer Health News Tags: Cancer Source Type: news

Polo-like-kinase 1 (PLK1) as a molecular target to overcome SYK-mediated resistance of B-lineage acute lymphoblastic leukaemia cells to oxidative stressEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is the first to identify PLK1 as a regulator of SYK tyrosine kinase and a molecular target to overcome SYK-mediated resistance of B-lineage ALL cells to OS. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 12, 2009 Category: Hematology Authors: Fatih M. Uckun, Zahide Ozer, Sanjive Qazi, Lisa Tuel-Ahlgren, Chen Mao Source Type: journals

Peripheral neuropathy in survivors of childhood acute lymphoblastic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to determine the prevalence of neuropathy and its impact on motor function and quality of life (QOL) among children who survived ALL. Thirty-seven survivors of childhood ALL aged 8[ndash]18 underwent evaluation for neuropathy through self-reported symptoms, standardized examinations, and nerve conduction studies (NCS). Functional impact of neuropathy was assessed using the Bruininks-Oseretsky test of Motor Proficiency (BOT-2). QOL was assessed using the PedsQL. Nerve conduction study abnormalities were seen in 29.7% of children who were longer than 2 years off therapy for ALL. Most children ...
Source: Journal of the Peripheral Nervous System - November 10, 2009 Category: Neurology Authors: Sindhu Ramchandren, Marcia Leonard, Rajen J. Mody, Janet E. Donohue, Judith Moyer, Raymond Hutchinson, James G. Gurney Tags: RESEARCH REPORTS Source Type: journals

Epidemiological Study on Survival of Chronic Myeloid Leukemia (CML) and Ph+ Acute Lymphoblastic Leukemia (ALL) Patients With BCR-ABL T315I MutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In patients with BCR-ABL–positive (Ph+) leukemia, the T315I mutation is associated with a high degree of resistance to imatinib, dasatinib, and nilotinib. Little published information exits regarding the... The... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - November 7, 2009 Category: Cancer & Oncology Source Type: journals

ERYtech Pharma Starts Its Pivotal Clinical Trial For GRASPA(R) In Acute Lymphoblastic LeukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ERYtech Pharma announces the start of its pivotal clinical trial for GRASPA®, its lead product in Acute Lymphoblastic Leukaemia. This phase III trial has begun in France and will be enlarged to a European scale. Up to 80 patients with relapsed Acute Lymphoblastic Leukaemia, aged from 1 to 55 years old will be enrolled. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 7, 2009 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news

ERYtech Pharma Starts Its Pivotal Clinical Trial For GRASPA(R) In Acute Lymphoblastic LeukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ERYtech Pharma announces the start of its pivotal clinical trial for GRASPA®, its lead product in Acute Lymphoblastic Leukaemia. This phase III trial has begun in France and will be enlarged to a European scale. Up to 80 patients with relapsed Acute Lymphoblastic Leukaemia, aged from 1 to 55 years old will be enrolled. The endpoint combines safety and efficacy with regard to the asparagine depletion level. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 7, 2009 Category: Cancer & Oncology Tags: Lymphoma / Leukemia / Myeloma Source Type: news

Revision of the risk of secondary leukaemia after mitoxantrone in multiple sclerosis populations is requiredEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective in this paper is to compare the cumulative incidence and incidence density of therapy-related acute myeloid leukaemia in two cohorts of patients with multiple sclerosis treated with mitoxantrone, and with previously reported data in the literature. Six new cases of acute myeloid leukaemia were observed by prospectively following two Spanish series of 142 and 88 patients with worsening relapsing multiple sclerosis and secondary-progressive disease treated with mitoxantrone. A literature review shows 32 further cases of acute myeloid leukaemia reported, 65.6% of which are therapy-related acute promyelocytic leu...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Pascual, A. M, Tellez, N., Bosca, I., Mallada, J., Belenguer, A., Abellan, I., Sempere, A. P, Fernandez, P., Magraner, M. J., Coret, F., Sanz, M. A, Montalban, X., Casanova, B. Tags: Articles Source Type: journals

Antigen receptor gene rearrangements reflect on the heterogeneity of adult Acute Lymphoblastic Leukaemia (ALL) with implications of cell-origin of ALL subgroups – a UKALLXII studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cytogenetic and molecular investigations of Acute Lymphoblastic Leukaemia (ALL) have identified the existence of distinct clinical subgroups. Molecular monitoring of clonal Immunoglobulin and T cell receptor (IG/TR) gene rearrangements has become an important tool in stratification of therapy of ALL. In order to determine whether certain features of the patient-specific rearrangements could hold further prognostic clues or provide information on the cell of origin of ALL, a comprehensive analysis of structural and biological features (V gene usage, coding frame and mutational status and complementarity-determining region -...
Source: British Journal of Haematology - November 6, 2009 Category: Hematology Authors: Lena Rai, Anouska Casanova, Anthony V. Moorman, Sue Richards, Georgina Buck, Anthony H. Goldstone, Adele K. Fielding, Letizia Foroni Source Type: journals

Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 unitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Umbilical cord blood (UCB) transplantation is potentially curative for acute leukemia. This analysis was performed to identify risk factors associated with leukemia relapse following myeloablative UCB transplantation. Acute leukemia patients (n = 177; 88 with acute lymphoblastic leukemia and 89 with acute myeloid leukemia) were treated at a single center. Patients received a UCB graft composed of either 1 (47%) or 2 (53%) partially human leukocyte antigen (HLA)–matched unit(s). Conditioning was with cyclophosphamide and total body irradiation with or without fludarabine. The incidence of relapse was 26% (95% confiden...
Source: Blood - November 5, 2009 Category: Hematology Authors: Verneris, M. R., Brunstein, C. G., Barker, J., MacMillan, M. L., DeFor, T., McKenna, D. H., Burke, M. J., Blazar, B. R., Miller, J. S., McGlave, P. B., Weisdorf, D. J., Wagner, J. E. Tags: Transplantation, Free Research Articles Source Type: journals

Remission Rate After First Early ALL Relapse Better Than Expected in Retrospective StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A retrospective study of children with acute lymphoblastic leukemia (ALL) suggests that the remission rate after first relapse may be higher than previously reported. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 4, 2009 Category: Consumer Health News Tags: Hematology-Oncology Source Type: news

Therapy-related myelodysplastic syndrome/acute myeloid leukemia after treatment with temozolomide in a patient with glioblastoma multiforme.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Therapy-related myelodysplastic syndrome and acute leukemia after treatment with temozolomide have rarely been described in the literature. Only 10 cases in association with temozolomide have been documented. The cases included anaplastic astrocytoma (4 cases), anaplastic oligodendroglioma (2 cases), low grade astrocytoma (2 cases), low grade oligodendroglioma (1 case), and one case of secondary Philadelphia-positive acute lymphoblastic leukemia in a patient with glioblastoma multiforme. Here we report a novel case of therapy-related myelodysplastic syndrome/acute myeloid leukemia associated with der(1;7)(q10;p10) in a...
Source: Annals of Clinical and Laboratory Science - November 3, 2009 Category: Laboratory Medicine Authors: Kim SJ, Park TS, Lee ST, Song J, Suh B, Kim SH, Jang SJ, Lee CH, Choi JR Tags: Ann Clin Lab Sci Source Type: journals

Dasatinib-induced complete molecular response after allogeneic hematopoietic stem cell transplantation in Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to prior imatinib-containing regimen: a case report and discussionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Presence of the Philadelphia chromosome in acute lymphoblastic leukemia is the single most adverse prognostic marker associated with high risk of disease relapse and poor prognosis. Allogeneic haematopoietic stem cell transplantation is considered as the only curative option in adults with Philadelphia-positive acute lymphoblastic leukemia, but relapse remains the main cause of treatment failure. Moreover, long-term survival rates are markedly decreased when transplanted patients are not in complete remission. Incorporation of tyrosine kinase inhibitors into transplantation strategy in patients with...
Source: Medical Oncology - November 3, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Survival outcome in childhood acute lymphoblastic leukemia in India: ResponseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Ketan Prasad Kulkarni, Ram Kumar Marwaha, Amita Trehan, Deepak Bansal Source Type: journals

Inhibitory role of cAMP on doxorubicin-induced apoptosis in pre-B ALL cells through dephosphorylation of p53 serine residuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our results suggest that activation of cAMP-signaling system may repress p53-dependent apoptosis in malignant cells exposed to doxorubicin. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10495-009-0417-8Authors Majid Safa, Iran University of Medical Sciences Department of Hematology, Faculty of Allied Medicine P.O. Box # 14155-6183 Tehran IranAhmad Kazemi, Iran University of Medical Sciences Department of Hematology, Faculty of Allied Medicine P.O. Box # 14155-6183 Tehran IranHamid Zand, Shahid Beheshti University M. C. Department of Basic Medical Sciences, National Nutrition and Food ...
Source: Apoptosis - November 2, 2009 Category: Molecular Biology Tags: Apoptosis Source Type: journals

p16INK4A Sensitizes Human Leukemia Cells to FAS- and Glucocorticoid-induced Apoptosis via Induction of BBC3/Puma and Repression of MCL1 and BCL2 [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Loss of CDKN2A/p16INK4A in hematopoietic stem cells is associated with enhanced self-renewal capacity and might facilitate progression of damaged stem cells into pre-cancerous cells that give rise to leukemia. This is also reflected by the frequent loss of the INK4A locus in acute lymphoblastic T-cell leukemia. T-cell acute lymphoblastic leukemia cells designed to conditionally express p16INK4A arrest in the G0/G1 phase of the cell cycle and show increased sensitivity to glucocorticoid- and tumor necrosis factor receptor superfamily 6-induced apoptosis. To investigate the underlying molecular mechanism for increased death ...
Source: Journal of Biological Chemistry - October 30, 2009 Category: Chemistry Authors: Obexer, P., Hagenbuchner, J., Rupp, M., Salvador, C., Holzner, M., Deutsch, M., Porto, V., Kofler, R., Unterkircher, T., Ausserlechner, M. J. Tags: Mechanisms Of Signal Transduction Source Type: journals

Accurate molecular classification of cancer using simple rulesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In cancerous gene expression datasets, a small number of genes, even one or two if selected correctly, is capable of achieving an ideal cancer classification effect. This finding also means that very simple rules may perform well for cancerous class prediction. (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - October 30, 2009 Category: Genetics & Stem Cells Authors: Xiaosheng WangOsamu Gotoh Source Type: journals

Toward a Total Cure for Acute Lymphoblastic Leukemia [EDITORIALS]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Pui Tags: Diagnosis & Staging, Combined Therapy, acute lymphoblastic leukemia EDITORIALS Source Type: journals

Risk of Relapse of Childhood Acute Lymphoblastic Leukemia Is Predicted By Flow Cytometric Measurement of Residual Disease on Day 15 Bone Marrow [Pediatric Oncology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Measurement of FCM MRD in day 15 bone marrow was the most powerful early predictor of relapse, applicable to virtually all patients; it may complement PCR MRD–based stratification including later time points, thus allowing additional treatment tailoring. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Basso, Veltroni, Valsecchi, Dworzak, Ratei, Silvestri, Benetello, Buldini, Maglia, Masera, Conter, Arico, Biondi, Gaipa Tags: acute lymphoblastic leukemia Pediatric Oncology Source Type: journals

Improved Early Event-Free Survival With Imatinib in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Children's Oncology Group Study [Pediatric Oncology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Imatinib plus intensive chemotherapy improved 3-year EFS in children and adolescents with Ph+ ALL, with no appreciable increase in toxicity. BMT plus imatinib offered no advantage over BMT alone. Additional follow-up is required to determine the impact of this treatment on long-term EFS and determine whether chemotherapy plus imatinib can replace BMT. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Schultz, Bowman, Aledo, Slayton, Sather, Devidas, Wang, Davies, Gaynon, Trigg, Rutledge, Burden, Jorstad, Carroll, Heerema, Winick, Borowitz, Hunger, Carroll, Camitta Tags: Clinical Trials, Chemotherapy, acute lymphoblastic leukemia Pediatric Oncology Source Type: journals

Young Adults With Acute Lymphoblastic Leukemia Have an Excellent Outcome With Chemotherapy Alone and Benefit From Intensive Postinduction Treatment: A Report From the Children's Oncology Group [Hematologic Malignancies]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Young adult patients with ALL showing a rapid response to induction chemotherapy benefit from early intensive postinduction therapy but do not benefit from a second interim maintenance and delayed intensification phase. Given the excellent outcome with this chemotherapy, there seems to be no role for the routine use of allogeneic stem-cell transplantation in first remission for young adults with ALL. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Nachman, La, Hunger, Heerema, Gaynon, Hastings, Mattano, Sather, Devidas, Freyer, Steinherz, Seibel Tags: Leukemia, Lymphoma, Solid Tumors (Pediatric) Hematologic Malignancies Source Type: journals

IKZF1 (Ikaros) Deletions in BCR-ABL1-Positive Acute Lymphoblastic Leukemia Are Associated With Short Disease-Free Survival and High Rate of Cumulative Incidence of Relapse: A GIMEMA AL WP Report [Hematologic Malignancies]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We conclude that IKZF1 deletions are likely to be a genomic alteration that significantly affects the prognosis of Ph-positive ALL in adults. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Martinelli, Iacobucci, Storlazzi, Vignetti, Paoloni, Cilloni, Soverini, Vitale, Chiaretti, Cimino, Papayannidis, Paolini, Elia, Fazi, Meloni, Amadori, Saglio, Pane, Baccarani, Foa Tags: Leukemia, Risk factors, Biology & Immunology Hematologic Malignancies Source Type: journals

Outcome of congenital acute lymphoblastic leukemia treated on the Interfant-99 protocolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acute lymphoblastic leukemia (ALL) diagnosed in the first month of life (congenital ALL) is very rare. Although congenital ALL is often assumed to be fatal, no studies have been published on outcome except for case reports. The present study reports the outcome of 30 patients with congenital ALL treated with the uniform Interfant-99 protocol, a hybrid regimen combining ALL treatment with elements designed for treatment of acute myeloid leukemia. Congenital ALL was characterized by a higher white blood cell count and a strong trend for higher incidence of MLL rearrangements and CD10-negative B-lineage ALL compared with olde...
Source: Blood - October 29, 2009 Category: Hematology Authors: van der Linden, M. H., Valsecchi, M. G., De Lorenzo, P., Moricke, A., Janka, G., Leblanc, T. M., Felice, M., Biondi, A., Campbell, M., Hann, I., Rubnitz, J. E., Stary, J., Szczepanski, T., Vora, A., Ferster, A., Hovi, L., Silverman, L. B., Pieters, R. Tags: Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: journals

Increased levels of tissue factor activity and procoagulant phospholipids during treatment of children with acute lymphoblastic leukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, these data indicate that, in addition to the well-identified increased in coagulation factors and inhibitor deficiencies, the injury of the endothelium could lead to the release of TF and PPL and could contribute to the hypercoagulability of children treated for ALL. (Source: British Journal of Haematology)
Source: British Journal of Haematology - October 29, 2009 Category: Hematology Authors: Pascale Schneider, Patrick Van Dreden, Aurélie Rousseau, Yusra Kassim, Elisabeth Legrand, Jean-Pierre Vannier, Marc Vasse Source Type: journals

Successful Treatment of Hepatic Encephalopathy in a Patient with Acute Lymphoblastic Leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of a 32-year-old woman with severe icterus, thrombocytopenia, neutropenia and hepatosplenomegaly. ALL was diagnosed. One day after admission, she developed hepatic encephalopathy with ammonia concentrations in plasma >100 mumol/l. Hepatic infiltration was presumed and chemotherapy was initiated immediately which led to resolution of hepatic encephalopathy and complete hematological remission. Clinicians should be aware of unusual presentations of ALL and difficulties for the application of chemotherapy in patients with liver failure. PMID: 19887778 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - October 29, 2009 Category: Hematology Authors: Dada R, Wilop S, Jost E, Galm O, Gassler N, Osieka R Tags: Acta Haematol Source Type: journals

Successful Treatment of Hepatic Encephalopathy in a Patient with Acute Lymphoblastic LeukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acta Haematol 2009;122:216-220 (DOI:10.1159/000253029) (Source: Karger Publishers)
Source: Karger Publishers - October 28, 2009 Category: Cancer & Oncology Source Type: journals

Childhood Acute Lymphoblastic LeukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Childhood Acute Lymphoblastic LeukemiaCategory: Diseases and ConditionsCreated: 10/28/2009 5:07:00 PMLast Editorial Review: 10/28/2009 5:07:19 PM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - October 28, 2009 Category: Cancer & Oncology Source Type: consumer

T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics and outcome from the large randomised prospective trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No standard of care exists for patients with adult T-lineage acute lymphoblastic leukemia (ALL). In this prospective, randomized trial of 356 patients, Marks et al describe clinical features, cytogenetics... The... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - October 27, 2009 Category: Cancer & Oncology Source Type: journals

Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Translocations resulting in ectopic expression of the TLX1 homeobox gene (previously known as HOX11) are recurrent events in human T-cell acute lymphoblastic leukemia (T-ALL). Transduction of primary murine hematopoietic stem/progenitor cells with retroviral vectors expressing TLX1 readily yields immortalized hematopoietic progenitor cell lines. Understanding the processes involved in TLX1-mediated cellular immortalization should yield insights into the growth and differentiation pathways altered by TLX1 during the development of T-ALL. In recent clinical gene therapy trials, hematopoietic clonal dominance or T-ALL-like di...
Source: Genes, Chromosomes and Cancer - October 27, 2009 Category: Cancer & Oncology Authors: Lynnsey A. Zweier-Renn, Teresa S. Hawley, Sandra Burkett, Ali Ramezani, Irene Riz, Rima L. Adler, Dennis D. Hickstein, Robert G. Hawley Source Type: journals

DNA Variants in Region for Noncoding Interfering Transcript of Dihydrofolate Reductase Gene and Outcome in Childhood Acute Lymphoblastic Leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The study provides a new insight into DHFR regulatory variations predisposing to an event in ALL patients. (Clin Cancer Res 2009;15(22):OF1-8). PMID: 19861437 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 27, 2009 Category: Cancer & Oncology Authors: Al-Shakfa F, Dulucq S, Brukner I, Milacic I, Ansari M, Beaulieu P, Moghrabi A, Laverdière C, Sallan SE, Silverman LB, Neuberg D, Kutok JL, Sinnett D, Krajinovic M Tags: Clin Cancer Res Source Type: journals

Fathers' Views and Understanding of their Roles in Families with a Child with Acute Lymphoblastic Leukaemia: An Interpretative Phenomenological AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study explored how fathers of children diagnosed with acute lymphoblastic leukaemia (ALL) perceived and understood the roles they had within their family over the course of their child’s illness and treatment. In-depth semi-structured interviews were conducted with five fathers. Transcripts were analysed using interpretative phenomenological analysis (IPA). The major themes that emerged were: adjusting to the diagnosis; the experience of maternal gate-keeping; striving for normalization; experiences of giving and receiving support. Overall, the fathers perceived themselves as having significant responsibility in...
Source: Journal of Health Psychology - October 26, 2009 Category: Psychiatry & Psychology Authors: Hill, K., Higgins, A., Dempster, M., McCarthy, A. Tags: Articles Source Type: journals

Minimal residual disease is a significant predictor of treatment failure in non T-lineage adult acute lymphoblastic leukaemia: final results of the international trial UKALL XII/ECOG2993Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The predictive value of molecular minimal residual disease (MRD) monitoring using polymerase chain reaction amplification of clone-specific immunoglobulin or T-cell Receptor rearrangements was analysed in 161 patients with non T-lineage Philadelphia-negative acute lymphoblastic leukaemia (ALL) participating in the UK arm of the international ALL trial UKALL XII/Eastern Cooperative Oncology Group (ECOG) 2993. MRD positivity ([ge]10[minus]4) in patients treated with chemotherapy alone was associated with significantly shorter relapse-free survival (RFS) at several time-points during the first year of therapy. MRD status best...
Source: British Journal of Haematology - October 26, 2009 Category: Hematology Authors: Bella Patel, Lena Rai, Georgina Buck, Sue M. Richards, Yeasmin Mortuza, Wayne Mitchell, Gareth Gerrard, Anthony V. Moorman, Veronique Duke, A. Victor Hoffbrand, Adele K. Fielding, Anthony H. Goldstone, Letizia Foroni Source Type: journals

The Wnt signaling pathway regulates Nalm-16 b-cell precursor acute lymphoblastic leukemic cell line survival and etoposide resistance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common malignancy in children. The Wnt signaling pathway has been found to be extensively involved in cancer onset and progression but its role in BCP-ALL remains controversial. We evaluate the role of the Wnt pathway in maintenance of BCP-ALL cells and resistance to chemotherapy. Gene expression profile revealed that BCP-ALL cells are potentially sensitive to modulation of Wnt pathway. Nalm-16 and Nalm-6 cell lines displayed low levels of canonical activation, as reflected by the virtually complete absence of total beta-catenin in Nalm-6 and the beta-...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - October 26, 2009 Category: Drugs & Pharmacology Authors: Thiago LS, Costa ES, Lopes DV, Otazu IB, Nowill AE, Mendes FA, Portilho DM, Abreu JG, Mermelstein CS, Orfao A, Rossi MI, Borojevic R Tags: Biomed Pharmacother Source Type: journals

Aberrant underexpression of CD81 in precursor B-cell acute lymphoblastic leukemia: utility in detection of minimal residual disease by flow cytometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We studied CD81 expression by flow cytometry (FC) on benign precursor B cells (hematogones) and leukemic blasts in precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) and established its usefulness in minimal residual disease (MRD) assays. Hematogones showed uniformly bright CD81 expression. In 98 pre-B-ALLs at diagnosis or overt relapse, 80 (82%) showed aberrantly decreased CD81 intensity. We used hematogones in 139 MRD- specimens to set a lower threshold for normal CD81 expression. In 133 specimens positive for residual pre-B-ALL, 87.2% showed increased CD81-dim immature B cells (>10%) and/or a discrete clus...
Source: American Journal of Clinical Pathology - October 24, 2009 Category: Pathology Authors: Muzzafar T, Medeiros LJ, Wang SA, Brahmandam A, Thomas DA, Jorgensen JL Tags: Am J Clin Pathol Source Type: journals

Components of the metabolic syndrome in 500 adult long-term survivors of childhood cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Adult survivors of childhood cancer, especially those treated with cranial irradiation, are at increased risk of developing the metabolic syndrome. PMID: 19850641 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 22, 2009 Category: Cancer & Oncology Authors: van Waas M, Neggers SJ, Pieters R, van den Heuvel-Eibrink MM Tags: Ann Oncol Source Type: journals

Turbid serum in a patient of acute lymphoblastic leukemia on treatment-What to look for?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Singh Tejinder, Satheesh C T, Madhumathi D S, Goyal Mukul, Rajeev L K, Lakshmaiah K C, Suresh T M, Babu K GovindJournal of Cancer Research and Therapeutics 2009 5(3):219-220 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - October 21, 2009 Category: Cancer & Oncology Authors: Singh Tejinder, Satheesh C T, Madhumathi D S, Goyal Mukul, Rajeev L K, Lakshmaiah K C, Suresh T M, Babu K Govind Source Type: journals

New Chromosomal Abnormality Identified In Leukemia Associated With Down SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers identified a new chromosomal abnormality in acute lymphoblastic leukemia that appears to work in concert with another mutation to give rise to cancer. This latest anomaly is particularly common in children with Down syndrome. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 19, 2009 Category: Science Source Type: news

Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The biological behavior of childhood B-lineage acute lymphoblastic leukemia (B-ALL) is different from that of adults. We performed a comprehensive analysis of the deletion and the methylation profile of CDKN2A (hereafter identified separately as p16 and p14, for the different proteins encoded) and CDKN2B (hereafter p15) in 91 newly diagnosed B-ALL patients (61 children, 30 adults). The prognostic significance of the profiles of these genes and the association between alterations in these genes and known cytogenetic prognostic factors (BCR/ABL; ETV6/RUNX1, formerly TEL/AML1; MLL rearrangement; and ploidy changes o...
Source: Cancer Genetics and Cytogenetics - October 19, 2009 Category: Genetics & Stem Cells Authors: Miyoung Kim, Seon-Hee Yim, Nam-Sun Cho, Seong-Ho Kang, Dae-Hyun Ko, Bora Oh, Tae Young Kim, Hyun Jung Min, Cha Ja She, Hyoung Jin Kang, Hee Yung Shin, Hyo-Sup Ahn, Sung Soo Yoon, Byoung Kook Kim, Hai-Rim Shin, Kyu Sup Han, Han Ik Cho, Dong Soon Lee Tags: Original articles Source Type: journals

TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Genomic and immunologic surveillance mechanisms are crucial in protection from cancer. The tumor suppressor protein p53, encoded by TP53, is a major regulator of genome surveillance. Among the natural sequence variants of TP53, rs1042522 (R72P) modifies the risk for solid tumors. To investigate its relevance in childhood acute lymphoblastic leukemia (ALL) susceptibility, we genotyped 114 cases and 414 newborn controls from Wales (UK) for polymorphisms in TP53 (R72P), its negative regulator MDM2 (single-nucleotide polymorphism SNP309, rs2279744), and selected HLA complex genes whose products interact with TP53. TP...
Source: Cancer Genetics and Cytogenetics - October 19, 2009 Category: Genetics & Stem Cells Authors: Thuy N. Do, Esma Ucisik-Akkaya, Charronne F. Davis, Brittany A. Morrison, M. Tevfik Dorak Tags: Original articles Source Type: journals

New chromosomal abnormality identified in leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists identified a new chromosomal abnormality in acute lymphoblastic leukemia (ALL) that appears to work in concert with another mutation to give rise to cancer. This latest anomaly is especially common in children with Down syndrome. The findings have already resulted in new diagnostic tests and potential tools for tracking a patient's response to therapy. The research, led by researchers from St. Jude Children's Research Hospital, also highlights a new potential ALL therapy. Clinicians are already planning trials of an experimental medicine targeting one of the altered genes........ (Source: Medicineworld.org: New Article Alert)
Source: Medicineworld.org: New Article Alert - October 19, 2009 Category: Consumer Health News Source Type: info

New Chromosomal Abnormality Identified In Leukemia Associated With Down SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers identified a new chromosomal abnormality in acute lymphoblastic leukemia (ALL) that appears to work in concert with another mutation to give rise to cancer. This latest anomaly is particularly common in children with Down syndrome. The findings have already resulted in new diagnostic tests and potential tools for tracking a patient's response to treatment. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 19, 2009 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news

Abnormality in Leukemia Associated with Down SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A study led by St. Jude Children's Research Hospital investigators expands understanding of acute lymphoblastic leukemia in children with Down syndrome, fueling hope for new treatment. Researchers identified a new chromosomal abnormality in acute lymphoblastic leukemia (ALL) that appears to work in concert with another mutation to give rise to cancer. This latest anomaly is particularly common in children with Down syndrome. (Source: Disabled World)
Source: Disabled World - October 19, 2009 Category: Disability Tags: Leukemia Source Type: info