Age-Related Macular Degeneration (AMD)This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Patients Win With Immediate Avastin Payment ReversalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Following efforts by the American Academy of Ophthalmology with the help of the American Society of Retina Specialists, the Macula Society, the Retina Society and Congressional allies, the Center for Medicare and Medicaid Services (CMS) said that it will retract an Oct. 1 payment policy for small doses of Avastin. Avastin, a cancer drug, is used in smaller doses to treat eye diseases such as age-related macular degeneration (AMD). (Source: Eye Health / Optometry News From Medical News Today)
Source: Eye Health / Optometry News From Medical News Today - November 20, 2009 Category: Opthalmology Tags: Eye Health / Blindness Source Type: news

Optic disc image in advanced age-related macular degenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aging Health , December 2009, Vol. 5, No. 6, Pages 733-741. (Source: Future Medicine: Aging Health)
Source: Future Medicine: Aging Health - November 19, 2009 Category: Geriatrics Tags: article Source Type: journals

Smoking Causes BlindnessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AMD Alliance International strongly urges all smokers to participate in the Great American Smokeout on November 19 to save their eyes and protect their vision from the debilitating effects of macular degeneration. Research has demonstrated that age-related macular degeneration (AMD), a progressive disease that causes the loss of central vision, is two to three times as frequent among tobacco smokers, and the risk is dose dependent(1, 2). (Source: Eye Health / Optometry News From Medical News Today)
Source: Eye Health / Optometry News From Medical News Today - November 18, 2009 Category: Opthalmology Tags: Smoking / Quit Smoking Source Type: news

The anti-angiogenic isoforms of VEGF in health and disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anti-angiogenic VEGF (vascular endothelial growth factor) isoforms, generated from differential splicing of exon 8, are widely expressed in normal human tissues but down-regulated in cancers and other pathologies associated with abnormal angiogenesis (cancer, diabetic retinopathy, retinal vein occlusion, the Denys-Drash syndrome and pre-eclampsia). Administration of recombinant VEGF(165)b inhibits ocular angiogenesis in mouse models of retinopathy and age-related macular degeneration, and colorectal carcinoma and metastatic melanoma. Splicing factors and their regulatory molecules alter splice site selection, such that...
Source: Biochemical Society Transactions - November 18, 2009 Category: Biochemistry Authors: Qiu Y, Hoareau-Aveilla C, Oltean S, Harper SJ, Bates DO Tags: Biochem Soc Trans Source Type: journals

Cataract Surgery Unlikely to Affect the Progression of AMDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In patients with non-neovascular age-related macular degeneration (AMD), cataract surgery is not associated with an increased risk of AMD progression. In addition, dietary fats may have differential effects on the risk of AMD, according to two studies in the November issue of the Archives of Ophthalmology. (Source: Modern Medicine)
Source: Modern Medicine - November 16, 2009 Category: Journals (General) Source Type: info

Does neuroinflammation fan the flame in neurodegenerative diseases?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
While peripheral immune access to the central nervous system (CNS) is restricted and tightly controlled, the CNS is capable of dynamic immune and inflammatory responses to a variety of insults. Infections, trauma, stroke, toxins and other stimuli are capable of producing an immediate and short lived activation of the innate immune system within the CNS. This acute neuroinflammatory response includes activation of the resident immune cells (microglia) resulting in a phagocytic phenotype and the release of inflammatory mediators such as cytokines and chemokines. While an acute insult may trigger oxidative and nitrosative str...
Source: Molecular Neurodegeneration - November 16, 2009 Category: Neurology Authors: Tamy Frank-CannonLaura AltoFiona McAlpineMalu Tansey Source Type: journals

[N,N-Bis(diphenylphosphino)propylamine-κ2P,P]bromidotricarbonylrhenium(I)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the title compound, [ReBr(C27H27NP2)(CO)3], the ReI atom is octahedrally surrounded by three carbonyl ligands in a facial arrangement, a bromide ligand and the P,P′-bidentate ligand Bis(diphenylphosphino)propylamine. The compound exhibits substitutional disorder of the bromide ligand and the axial carbonyl ligand, with almost 50% occupancy for both Br amd CO [0.538 (4) and 0.462 (4), respectively]. In addition, the propyl chain on the N atom of the bidentate ligand exhibits a 0.648 (9):0.352 (9) disorder. C—H...O and C—H...Br hydrogen bonding consolidates the crystal packing. (Source: Acta Crystallographica Section E)
Source: Acta Crystallographica Section E - November 14, 2009 Category: Chemistry Authors: Schutte, M.Visser, H.G.Brink, A. Tags: metal-organic compounds Source Type: journals

Egg Yolks May Reduce Risk of Age-Related Macular DegenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Regular egg yolk consumption may reduce the risk of dry, age-related macular degeneration by raising macular pigment concentrations, according to a report in the November issue of the American Journal of Clinical Nutrition. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 13, 2009 Category: Consumer Health News Tags: Ophthalmology Source Type: news

Does cataract surgery make eye disease worse?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW YORK (Reuters Health) - Cataract surgery does not appear to worsen the course of age-related macular degeneration (AMD), a progressive loss of vision due to deterioration of nerve tissue in the retina, a new study shows. (Source: Reuters: Health)
Source: Reuters: Health - November 13, 2009 Category: Consumer Health News Tags: healthNews Source Type: news

Cystatin C in macular and neuronal degenerations: Implications for mechanism(s) of Age-related Macular Degeneration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cystatin C is a strong inhibitor of cysteine proteinases expressed by diverse cells. Variant B cystatin C, which was associated with increased risk of developing age-related macular degeneration, differs from the wild type protein by a single amino acid (A25T) in the signal sequence responsible for its targeting to the secretory pathway. The same variant conveys susceptibility to Alzheimer disease. Our investigations of the trafficking and processing of variant B cystatin C in living RPE cells highlight impaired secretion of extracellular modulators and inappropriate protein retention in RPE cells as potential molecula...
Source: Vision Research - November 13, 2009 Category: Opthalmology Authors: Paraoan L, Hiscott P, Gosden C, Grierson I Tags: Vision Res Source Type: journals

Does cataract surgery make eye disease worse?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW YORK (Reuters Health) - Cataract surgery does not appear to worsen the course of age-related macular degeneration (AMD), a progressive loss of vision due to deterioration of nerve tissue in the retina, a new study shows. (Source: Reuters: Health)
Source: Reuters: Health - November 12, 2009 Category: Consumer Health News Tags: healthNews Source Type: news

NeoVista, Inc. Announces First Neovascular AMD Patient Treated with VIDION® ANV® Therapy System in Europe Following CommercializationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ophthalmic Clinic in Pisa, Italy is First in Europe to Treat Neovascular AMD Patients with New Epimacular Brachytherapy System (PRWeb Nov 12, 2009) Read the full story at http://www.prweb.com/releases/2009/11/prweb3192374.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - November 12, 2009 Category: Pharmaceuticals Source Type: news

Atrial Natriuretic Peptide Reduces Vascular Leakage and Choroidal Neovascularization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atrial natriuretic peptide (ANP) is a hormone with diuretic, natriuretic, and vasodilatory properties. ANP blocks vascular endothelial growth factor (VEGF) production and signaling in vitro; however, its role in vascular leakage and angiogenesis is unknown. In vitro, retinal barrier permeability (transepithelial electrical resistance (TEER)) was measured in cultured retinal endothelial (HuREC) and retinal epithelial (ARPE-19) cells with VEGF (10 ng/ml), ANP (1 pM to 1 mumol/L), and/or isatin, an ANP receptor antagonist. In vivo, blood-retinal barrier (BRB) leakage was studied using the Evans Blue dye technique in rats ...
Source: The American Journal of Pathology - November 12, 2009 Category: Pathology Authors: Lara-Castillo N, Zandi S, Nakao S, Ito Y, Noda K, She H, Ahmed M, Frimmel S, Ablonczy Z, Hafezi-Moghadam A Tags: Am J Pathol Source Type: journals

Complex Picture Emerges for Fat's Impact on the Eye (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A fat-filled diet may put younger women at risk for future age-related macular degeneration, although the effect varies by type of fat, researchers found. (Source: MedPage Today Ophthalmology)
Source: MedPage Today Ophthalmology - November 11, 2009 Category: Opthalmology Source Type: news

Aspirin/warfarin: Spontaneous suprachoroidal haemorrhage in an elderly patient with ARMD: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 11, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

No Increase in Macular Degeneration after Cataract Surgery (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cataract surgery does not increase the risk of progression of age-related macular degeneration, a prospective study found. Previous observational and case-control studies had suggested an acceleration in degeneration after surgery. (Source: MedPage Today Ophthalmology)
Source: MedPage Today Ophthalmology - November 10, 2009 Category: Opthalmology Source Type: news

Aging eye disorder no worse with cataract surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cataract surgery might not speed up age-related macular degeneration as previously thought, a new study suggests. (Source: CBC | Health)
Source: CBC | Health - November 10, 2009 Category: Consumer Health News Source Type: news

Variation in genetic admixture and population structure among Latinos - The Los Angeles Latino Eye Study (LALES)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings reflect the historic migration patterns of Native Americans and suggest that while the 'Latino' label is used to categorize the entire population, there exists a strong degree of heterogeneity within that population, and that it will be important to assess this heterogeneity within future association studies on Latino populations. Our study raises awareness of the diversity within "Latinos" and the necessity to assess appropriate risk and treatment management. (Source: BMC Genetics - Latest articles)
Source: BMC Genetics - Latest articles - November 10, 2009 Category: Genetics & Stem Cells Authors: Corina ShtirPaul MarjoramStanley AzenDavid ContiLoic Le MarchandChristopher HaimanRohit Varma Source Type: journals

Cataract Surgery Does Not Worsen Age-Related Macular DegenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from a new study do not support the hypothesis that cataract surgery increases the risk for age-related macular degeneration progression. Medscape Medical News (Source: Medscape Ophthalmology Headlines)
Source: Medscape Ophthalmology Headlines - November 9, 2009 Category: Opthalmology Tags: Ophthalmology Source Type: info

Progression of Age-Related Macular Degeneration After Cataract Surgery [Clinical Sciences]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The low incidence rate of neovascular AMD development between 1 week and 1 year after cataract surgery did not support the hypothesis that cataract surgery increases the risk of AMD progression. Several eyes appeared to have disease progression on postsurgery week 1 fluorescein angiograms, suggesting that many cases of presumed progression to neovascular AMD following cataract surgery may have been present prior to cataract surgery, but not recognized owing to lens opacity. (Source: Archives of Opthalmology)
Source: Archives of Opthalmology - November 9, 2009 Category: Opthalmology Authors: Dong, L. M., Stark, W. J., Jefferys, J. L., Al-Hazzaa, S., Bressler, S. B., Solomon, S. D., Bressler, N. M. Tags: Aging/ Geriatrics, Ophthalmology, Ophthalmological Disorders, Cataracts/ Lens, macular Degeneration, Ophthalmological Procedures, Ophthalmological Procedures, Other Clinical Sciences Source Type: journals

Association Between Dietary Fat Intake and Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): An Ancillary Study of the Women's Health Initiative [Epidemiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These results support a growing body of evidence suggesting that diets high in several types of fat may contribute to the risk of intermediate AMD and that diets high in monounsaturated fatty acids may be protective. (Source: Archives of Opthalmology)
Source: Archives of Opthalmology - November 9, 2009 Category: Opthalmology Authors: Parekh, N., Voland, R. P., Moeller, S. M., Blodi, B. A., Ritenbaugh, C., Chappell, R. J., Wallace, R. B., Mares, J. A., for the CAREDS Research Study Group Tags: Aging/ Geriatrics, Ophthalmology, Ophthalmological Disorders, macular Degeneration, Public Health, Diet Epidemiology Source Type: journals

Is the Risk of Incidence or Progression of Age-Related Macular Degeneration Increased After Cataract Surgery? [Editorial]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of Opthalmology)
Source: Archives of Opthalmology - November 9, 2009 Category: Opthalmology Authors: Klein, B. E. K. Tags: Aging/ Geriatrics, Ophthalmology, Ophthalmological Disorders, Cataracts/ Lens, macular Degeneration, Ophthalmological Procedures, Ophthalmological Procedures, Other, Patient-Physician Relationship/ Care, Patient-Physician Communication Editorial Source Type: journals

Cataract Surgery May Benefit Macular DegenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Individuals with varying degrees of age-related macular degeneration may benefit in terms of visual acuity from cataract surgery, according to the Age-Related Eye Disease Study published in the November issue of Ophthalmology. (Source: Modern Medicine)
Source: Modern Medicine - November 9, 2009 Category: Journals (General) Source Type: info

Intrasession repeatability of optical coherence tomography measures in active neovascular age-related macular degenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Optical coherence tomography-derived retinal thickness measurements are subject to measurement variability in patients with active nAMD. The results suggest a change criterion of more than 59 [mu]m in central 1 mm (A1) subfield macular thickness is necessary to distinguish true clinical change from measurement variability in these patients. (Source: Acta Ophthalmologica)
Source: Acta Ophthalmologica - November 9, 2009 Category: Opthalmology Authors: Praveen J. Patel, Fred K. Chen, Felicia Ikeji, Matthew Richardson, Lyndon Da Cruz, Adnan Tufail Source Type: journals

A spontaneous suprachoroidal haemorrhage: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Anticoagulation is common in those with cardiovascular disease, which increases the risk of haemorrhagic complications. These patients are also more likely to suffer from age related macular degeneration. Suprachoroidal haemorrhage should be considered in such patients presenting with suspicious signs and a low threshold should be had for investigating for this condition in such circumstances. Early detection may reduce the morbidity. (Source: BioMed Central)
Source: BioMed Central - November 6, 2009 Category: Journals (General) Authors: Aman ChandraAllon BarsamCharles Hugkulstone Source Type: journals

Persistent Spikes Seen in Intraocular Pressure After Anti-VEGF Injections for AMDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers find sustained spikes in intraocular pressure after treatment for wet age-related macular degeneration (AMD), even in patients with no known risk factors. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 5, 2009 Category: Consumer Health News Tags: Ophthalmology Source Type: news

Characterization of complement factor H-related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The factor H–related protein family (CFHR) is a group of minor plasma proteins genetically and structurally related to complement factor H (fH). Notably, deficiency of CFHR1/CFHR3 associates with protection against age-related macular degeneration and with the presence of anti-fH autoantibodies in atypical hemolytic uremic syndrome (aHUS). We have developed a proteomics strategy to analyze the CFHR proteins in plasma samples from controls, patients with aHUS, and patients with type II membranoproliferative glomerulonephritis. Here, we report on the identification of persons carrying novel deficiencies of CFHR1, CFHR3...
Source: Blood - November 5, 2009 Category: Hematology Authors: Abarrategui-Garrido, C., Martinez-Barricarte, R., Lopez-Trascasa, M., Rodriguez de Cordoba, S., Sanchez-Corral, P. Tags: Immunobiology, Thrombosis and Hemostasis, Clinical Trials and Observations Source Type: journals

Dietary n-3 PUFA Vascular Targeting and the Prevention of Tumor Growth and Age-Related Macular Degeneration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The protective role of dietary n-3 polyunsaturated fatty acids (PUFAs) against cardiovascular diseases has been partly related to their ability to modulate the risk condition known as "endothelial dysfunction", by reverting the endothelial alterations associated to it (reduced vascular reactivity, the proinflammatory state, and the prothrombotic properties). Moreover, vasculature represents the target for inhibition of pathologic neo-angiogenesis by n-3 PUFAs. This effect is believed to contribute to the beneficial action of these fatty acids against disorders which recognize neovascularization as a crucial pathogeneti...
Source: Current Medicinal Chemistry - November 5, 2009 Category: Chemistry Authors: Serini S, Piccioni E, Calviello G Tags: Curr Med Chem Source Type: journals

Current treatment options for retinal angiomatous proliferans (RAP).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Retinal angiomatous proliferation (RAP) accounts for 12-15% of all patients with neovascular age related macular degeneration (NV-AMD). However, this subtype is often excluded from clinical trials aimed at assessing the efficacy of various treatment options for NV-AMD. So, there are no established protocols for the management of RAP. This review of current literature on RAP compares the outcomes of various treatment options for this condition and highlights the lack of clinical trials and paucity of long-term data on this relatively common condition. PMID: 19897475 [PubMed - as supplied by publisher] (Source: The B...
Source: The British Journal of Ophthalmology - November 5, 2009 Category: Opthalmology Authors: Gupta BM, Jyothi S, Sivaprasad S Tags: Br J Ophthalmol Source Type: journals

Cataract Surgery Benefits AMD Patients; Steroid Drug May Restore Vision In DME Patients; Top Online Eye Health Forums AnalyzedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This month's Ophthalmology, the journal of the American Academy of Ophthalmology (Academy) reports on a national study that finds cataract surgery is likely to benefit patients with age-related macular degeneration (AMD) at all stages of the disease, on a clinical trial indication that the steroid (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 3, 2009 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news

Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In age-related macular degeneration (AMD), reduced lysosomal capacity may contribute to lipofuscinogenesis and progressive dysfunction of the retinal pigment epithelium (RPE). We previously demonstrated that lipid peroxidation-related protein modifications inhibit lysosomal degradation of photoreceptor outer segment (POS) proteins in RPE cells. Herein, we investigate the effects of lipid peroxidation products on activities of key RPE lysosomal proteases. In lysosomes isolated from primary human RPE cells, lipid peroxidation products 4-hydroxynonenal (HNE) and malondialdehyde (MDA) exerted a dose-dependent inhibitory ef...
Source: Experimental Eye Research - November 3, 2009 Category: Opthalmology Authors: Krohne TU, Kaemmerer E, Holz FG, Kopitz J Tags: Exp Eye Res Source Type: journals

AMD Patients Benefit From Cataract Surgery, StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new US study found that cataract surgery is likely to benefit pateints with all stages of age-related macular degeneration (AMD), from mild to advanced. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 2, 2009 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news

Increased Vitronectin Production by Complement-Stimulated Human Retinal Pigment Epithelial Cells [Immunology and Microbiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This experimental work shows that RPE cells produce vitronectin in an enhanced amount after stimulation with human complement serum. This may explain how complement activation can contribute to AMD. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Wasmuth, S., Lueck, K., Baehler, H., Lommatzsch, A., Pauleikhoff, D. Tags: Immunology and Microbiology Source Type: journals

CREB1/ATF1 Activation in Photoreceptor Degeneration and Protection [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The CREB1/ATF1 pathway is activated in canine and human rods and cones undergoing degeneration. The pathway is also activated by exposure to the neuroprotective agent CNTF. These data suggest that CREB1/ATF1 contributes to an innate protective response and is of potential therapeutic value in the treatment of RP and AMD. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Beltran, W. A., Allore, H. G., Johnson, E., Towle, V., Tao, W., Acland, G. M., Aguirre, G. D., Zeiss, C. J. Tags: Retina Source Type: journals

Interobserver Agreement for the Detection of Optical Coherence Tomography Features of Neovascular Age-Related Macular Degeneration [Retina]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reports the interobserver agreement for OCT features of neovascular AMD in a clinical setting. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Patel, P. J., Browning, A. C., Chen, F. K., Cruz, L. D., Tufail, A. Tags: Retina Source Type: journals

Contribution of Copy Number Variation in the Regulation of Complement Activation Locus to Development of Age-Related Macular Degeneration [Biochemistry and Molecular Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, both deletions and duplications of genes in the regulation of complement activation locus segregated in Caucasians. Deletion of CFHR3 and CFHR1 protected against the development of AMD, at least in part because the deletion tagged a protective haplotype and did not occur on the risk haplotype. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - November 2, 2009 Category: Opthalmology Authors: Schmid-Kubista, K. E., Tosakulwong, N., Wu, Y., Ryu, E., Hecker, L. A., Baratz, K. H., Brown, W. L., Edwards, A. O. Tags: Biochemistry and Molecular Biology Source Type: journals

Rapid inexpensive genome-wide association using pooled whole blood [METHODS]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genome-wide association studies (GWAS) have now successfully identified important genetic variants associated with many human traits and diseases. The high cost of genotyping arrays in large data sets remains the major barrier to wider utilization of GWAS. We have developed a novel method in which whole blood from cases and controls, respectively, is pooled prior to DNA extraction for genotyping. We demonstrate proof of principle by clearly identifying the associated variants for eye color, age-related macular degeneration, and pseudoexfoliation syndrome in cohorts not previously studied. Blood pooling has the potential to...
Source: Genome Research - November 2, 2009 Category: Genetics & Stem Cells Authors: Craig, J. E., Hewitt, A. W., McMellon, A. E., Henders, A. K., Ma, L., Wallace, L., Sharma, S., Burdon, K. P., Visscher, P. M., Montgomery, G. W., MacGregor, S. Tags: METHODS Source Type: journals

Cataract surgery helps AMD patients; steroid improves DME; online eye health forumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(American Academy of Ophthalmology) This month's Ophthalmology, the journal of the American Academy of Ophthalmology reports on a national study that finds cataract surgery is likely to benefit patients with age-related macular degeneration (AMD) at all stages of the disease, on a clinical trial showing that the steroid triamcinolone may be effective in advanced diabetic macular edema (DME) patients when standard treatment fails, and on the public's use of two Academy-sponsored online eye health forums. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 2, 2009 Category: Global & Universal Source Type: news

Nerve fiber layer thickness in exudative age-related macular degeneration in Japanese patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion There is no relationship between exudative AMD and peripapillary RNFL thickness in Japanese patients. Content Type Journal ArticleCategory Retinal DisordersDOI 10.1007/s00417-009-1222-3Authors Kentaro Yuda, University of Tokyo School of Medicine Department of Ophthalmology 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanYuji Inoue, University of Tokyo School of Medicine Department of Ophthalmology 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanAtsuo Tomidokoro, University of Tokyo School of Medicine Department of Ophthalmology 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanYasuhiro Tamaki, University of T...
Source: Graefe's Archive for Clinical and Experimental Ophthalmology - October 31, 2009 Category: Opthalmology Tags: Graefe's Archive for Clinical and Experimental Ophthalmology Source Type: journals

$16 Million Grant From State Stem Cell Agency To Speed Research Of Stem Cell-Based Treatment For Age-Related Macular DegenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Physician-researchers at the University of Southern California (USC) received a nearly $16 million grant from the California Institute of Regenerative Medicine (CIRM) to fund the development of a stem cell-based treatment for age-related macular degeneration, the leading cause of vision loss and blindness among the elderly. Mark Humayun, M.D., Ph.D. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 31, 2009 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news

Effects of combination therapy with verteporfin photodynamic therapy and ranibizumab in patients with age-related macular degenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Same-day verteporfin plus ranibizumab improved VA, reduced CRT, prevented CNV perfusion and reduced lesion area safely over 12 months. Further investigation is warranted to confirm whether this combination improves long-term vision and reduces the need for retreatment. (Source: Acta Ophthalmologica)
Source: Acta Ophthalmologica - October 30, 2009 Category: Opthalmology Authors: Ute E. K. Wolf-Schnurrbusch, Christian K. Brinkmann, Lisa Berger, Sebastian Wolf Source Type: journals

AAO: Photodynamic Therapy No Help in Treating Macular Degeneration (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAN FRANCISCO (MedPage Today) -- Photodynamic therapy doesn't add to the effectiveness of standard treatment of wet age-related macular degeneration or decrease the need for intravitreal injections, researchers said. (Source: MedPage Today Meeting Coverage)
Source: MedPage Today Meeting Coverage - October 29, 2009 Category: Journals (General) Source Type: info

Reticular Macular DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: RMD is a single disease entity with stereotypical presentations in multiple imaging methods, of which RPD is one. Autofluorescence, infrared imaging, and indocyanine green angiography suggest that it involves the retinal pigment epithelium and choriocapillaris, whereas photographic patterns implicate the inner choroid. Infrared imaging, unlike other methods, can demonstrate RMD in the central macula. RMD is associated with progression to advanced age-related macular degeneration, perhaps on an inflammatory basis. RMD deserves wider recognition among clinicians caring for elderly patients. (Source: American Jou...
Source: American Journal of Ophthalmology - October 29, 2009 Category: Opthalmology Authors: R. Theodore Smith, Mahsa A. Sohrab, Mihai Busuioc, Gaetano Barile Tags: Original Articles Source Type: journals

Cataract Surgery Helps AMD Patients; Steroid Improves DME; Online Eye Health ForumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This month's Ophthalmology, the journal of the American Academy of Ophthalmology (Academy) reports on a national study that finds cataract surgery is likely to benefit patients with age-related macular degeneration (AMD) at all stages of the disease, on a clinical trial showing that the steroid triam (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 29, 2009 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news

Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated the molecular and cellular effects of cigarette smoke exposure on human RPE cells. ARPE-19 or primary human RPE cells were exposed to cigarette smoke extract (CSE) or hydroquinone (HQ), a component of cigarette smoke. The effect of this exposure on key aspects of RPE vitality including viability, cell size, mitochondrial membrane potential (m), superoxide production, 4-hydroxy-2-nonenal (4-HNE), vascular endothelial growth factor (VEGF), and heme oxygenase-1 (HO-1) expression was determined. Exposure of RPE cells to CSE or HQ caused oxidative damage and apoptosis, characterized by a reduction in cel...
Source: AJP: Cell Physiology - October 29, 2009 Category: Cytology Authors: Bertram, K. M., Baglole, C. J., Phipps, R. P., Libby, R. T. Tags: NERVOUS SYSTEM CELL BIOLOGY Source Type: journals

USC physician-researchers receive $16 million grant from state stem cell agencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(University of Southern California) Physician-researchers at the University of Southern California received a nearly $16 million grant from the California Institute of Regenerative Medicine to fund the development of a stem cell-based treatment for age-related macular degeneration, the leading cause of vision loss and blindness among the elderly. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - October 28, 2009 Category: Global & Universal Source Type: news

AAO: Genes Linked to Response in Macular Degeneration (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAN FRANCISCO (MedPage Today) -- Genes may predict response to ranibizumab (Lucentis) for patients with neovascular age-related macular degeneration, according to a genome-wide association study. (Source: MedPage Today Meeting Coverage)
Source: MedPage Today Meeting Coverage - October 27, 2009 Category: Journals (General) Source Type: info

Protecting Against Age-Related Vision Loss With Blue Light-Filtering LensesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Age-related macular degeneration, a major cause of vision loss, affects millions of older persons Results of an important new study show that implantation of blue light-filtering intraocular lens (IOLs) at the time of cataract surgery increases a nutritional component of the eye, which may afford protection against the development and/or progression of age-related macular degeneration (AMD). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 27, 2009 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news

AMD Medication Raises Eye Pressure In Some Patients; Low-cost Vision Testing Could Benefit Millions WorldwideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A first-time finding of intraocular pressure increases in patients with no personal or family history of glaucoma following anti-VEGF treatment for wet age-related macular degeneration (AMD) , and a report on a simple, low-cost method that could revolutionize vision screening and treatment in develo (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 27, 2009 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news