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Smoking May Now Be Considered An Established Risk Factor For ALS, Also Known As Lou Gehrig's Disease
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While previous studies have indicated a "probable" connection between smoking and ALS, a new study published in the Nov. 17, 2009 issue of Neurology®, the medical journal of the American Academy of Neurology, states that smoking may now be considered an "established" risk factor for Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news
Smoking May Now Be Considered An Established Risk Factor For ALS, Also Known As Lou Gehrig's DiseaseEmail this article to a colleague.
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While previous studies have indicated a "probable" connection between smoking and ALS, a new study published in the Nov. 17, 2009 issue of Neurology®, the medical journal of the American Academy of Neurology, states that smoking may now be considered an "established" risk factor for Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease. The findings come from Baystate Medical Center neurologist Dr. (Source: Multiple Sclerosis News From Medical News Today)
Source: Multiple Sclerosis News From Medical News Today - November 18, 2009 Category: Neurology Tags: Multiple Sclerosis Source Type: news
Fragment C of tetanus toxin, more than a carrier. Novel perspectives in non-viral ALS gene therapyEmail this article to a colleague.
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Abstract The non-toxic carboxy-terminal fragment of tetanus toxin heavy chain (TTC) has been implicated in the activation of cascades
responsible for trophic actions and neuroprotection by inhibition of apoptosis. Previous in vitro studies have described signalling
pathways that underlie the administration of TTC to neurons. We investigated whether these properties were maintained in a
mouse model of neurodegenerative disease. Naked DNA encoding for TTC was injected intramuscularly and neuromuscular function
and clinical behaviour were monitored until endstage in the transgenic SOD1G93A mouse model that expr...
Source: Journal of Molecular Medicine - November 18, 2009 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals
BrainStorm Stem Cell Therapy Technology Possesses Promising Potential For The Future Treatment Of Multiple SclerosisEmail this article to a colleague.
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BrainStorm Cell Therapeutics Inc. (OTCBB:BCLI), a leading developer of adult stem cell technologies and therapeutics, is pleased to announce that the company's therapeutic approach for treating neurodegenerative diseases, particularly ALS and Parkinson's disease, was found to have a positive effect in a mouse model of multiple sclerosis (MS). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news
BrainStorm Stem Cell Therapy Technology Possesses Promising Potential For The Future Treatment Of Multiple SclerosisEmail this article to a colleague.
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BrainStorm Cell Therapeutics Inc. (OTCBB:BCLI), a leading developer of adult stem cell technologies and therapeutics, is pleased to announce that the company's therapeutic approach for treating neurodegenerative diseases, particularly ALS and Parkinson's disease, was found to have a positive effect in a mouse model of multiple sclerosis (MS). (Source: Multiple Sclerosis News From Medical News Today)
Source: Multiple Sclerosis News From Medical News Today - November 18, 2009 Category: Neurology Tags: Multiple Sclerosis Source Type: news
Smoking Lou Gehrig's disease risk factorEmail this article to a colleague.
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SPRINGFIELD, Mass., Nov. 18 (UPI) -- Smoking may now be considered an established risk factor for Amyotrophic Lateral Sclerosis, also known as Lou Gehrig's disease, U.S. researchers said. (Source: Health News - UPI.com)
Source: Health News - UPI.com - November 18, 2009 Category: Consumer Health News Source Type: news
Activation of STAT3 and inhibitory effects of pioglitazone on STAT3 activity in a mouse model of SOD1-mutated amyotrophic lateral sclerosisEmail this article to a colleague.
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Signal transducer and activator of transcription-3 (STAT3) is a member of the proinflammatory transcription factor STAT family. Several studies have documented implications for neuroinflammation in amyotrophic lateral sclerosis (ALS). We recently demonstrated activation of STAT3 in spinal cords obtained at autopsy from sporadic ALS patients. To determine the involvement of STAT3 and effects of pioglitazone on STAT3 activity in familial ALS with superoxide dismutase-1 (SOD1) mutation, we performed immunoblot and immunohistochemical analyses of the active form of STAT3 (p-STAT3) in spinal cords from mice overexpressing mutan...
Source: Neuropathology - November 18, 2009 Category: Neurology Authors: Noriyuki Shibata, Tomoko Yamamoto, Atsuko Hiroi, Yoko Omi, Yoichiro Kato, Makio Kobayashi Source Type: journals
Non-antibiotic selection systems for soybean somatic embryos:
the lysine analog aminoethyl-cysteine as a selection agentEmail this article to a colleague.
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Conclusions:
Genetically engineered soybeans expressing a lysine insensitive DHPS gene can be selected with the non-antibiotic selection agent AEC. We also report here the inhibitory effects of glufosinate, (isopropylamine-glyphosate) (Roundup(R)), AEC and the ALS inhibitors Exceed(R) and Synchrony(R) against different tissues of soybean. (Source: BMC Biotechnology - Latest articles)
Source: BMC Biotechnology - Latest articles - November 18, 2009 Category: Biotechnology Authors: Suryadevara RaoLewamy MamadouMatt McConnellRaghuveer PolisettyPrachuab KwanyuenDavid Hildebrand Source Type: journals
The occurrence of mutations in FUS in a Belgian cohort of patients with familial ALSEmail this article to a colleague.
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Conclusions: These results show that mutations in FUS are also a significant cause of familial ALS in Belgium. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 18, 2009 Category: Neurology Authors: P. Van Damme, A. Goris, V. Race, N. Hersmus, B. Dubois, L. Van Den Bosch, G. Matthijs, W. Robberecht Source Type: journals
Compliance bei langzeiterkrankten NarkolepsiepatientenEmail this article to a colleague.
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Zusammenfassung
Fragestellung Die Therapietreue gilt als Grundvoraussetzung für die Wirksamkeitsbeurteilung einer Therapie. In dieser Pilotstudie wurde
erstmals versucht, die Therapietreue mit und ohne Medikation bei Narkolepsiepatienten operationalisiert zu erfassen.
Patienten und Methodik Mit 49 Patienten, bei denen seit mindestens 5 Jahren die Diagnose „Narkolepsie“ besteht, wurde ein Telefoninterview zur Compliance
geführt. Hierbei wurde ein neu entwickelter Fragebogen erprobt.
Ergebnisse Mit Hilfe des neuen Fragebogens wurde bei 18,4% der Probanden ein hohes...
Source: Somnologie - Schlafforschung und Schlafmedizin - November 17, 2009 Category: Sleep Medicine Tags: Somnologie - Schlafforschung und Schlafmedizin Source Type: journals
Die diagnostische Genauigkeit der Polygraphie bei Patienten mit HerzinsuffizienzEmail this article to a colleague.
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Zusammenfassung
Hintergrund und Fragestellung Die Prävalenz von schlafbezogenen Atmungsstörungen (SBAS) bei Herzinsuffizienz ist hoch. Die ambulante Polygraphie (PG) wird
v. a. in der kardiologischen Diagnostik zunehmend eingesetzt. Zu ihrer Genauigkeit bei Patienten mit Herzinsuffizienz kann
zzt. keine zuverlässige Aussage gemacht werden. Ziel dieser Studie war es, den durch Polysomnographie (PSG) mit dem durch
PG ermittelten Apnoe-Hypopnoe-Index (AHI) als Basis der Entscheidung für ein Therapieverfahren zu vergleichen.
Methoden Patienten mit symptomatischer Herzinsuffizienz und e...
Source: Somnologie - Schlafforschung und Schlafmedizin - November 17, 2009 Category: Sleep Medicine Tags: Somnologie - Schlafforschung und Schlafmedizin Source Type: journals
Bewältigungsstrategien beim Restless-legs-SyndromEmail this article to a colleague.
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Zusammenfassung Das Restless-legs-Syndrom (RLS) gehört nach heutigem Wissen zu den häufigsten neurologischen Erkrankungen. Es ist durch einen
Bewegungsdrang in den Beinen gekennzeichnet, der meistens mit Missempfindungen oder Schmerzen assoziiert ist. Typisch dabei
ist, dass die Beschwerden abends und in der Nacht bzw. in Ruhesituationen auftreten und sich durch Bewegung oder Aktivität
lindern lassen. Die Indikation zur Therapie stellt sich aufgrund des Leidensdrucks, meistens infolge der Schlafstörungen und
der damit verbundenen Beeinträchtigung. Der Verlauf der Erkrankung ist meistens chronisch, komor...
Source: Somnologie - Schlafforschung und Schlafmedizin - November 17, 2009 Category: Sleep Medicine Tags: Somnologie - Schlafforschung und Schlafmedizin Source Type: journals
Smoking May Now Be Considered An Established Risk Factor For ALSEmail this article to a colleague.
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While previous studies have indicated a "probable" connection between smoking and ALS, a new study published in the Nov. 17, 2009 issue of Neurology®, the medical journal of the American Academy of Neurology, states that smoking may now be considered an "established" risk factor for Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 17, 2009 Category: Consumer Health News Tags: Smoking / Quit Smoking Source Type: news
Smoking May Now Be Considered An Established Risk Factor For ALSEmail this article to a colleague.
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While previous studies have indicated a "probable" connection between smoking and ALS, a new study published in the Nov. 17, 2009 issue of Neurology®, the medical journal of the American Academy of Neurology, states that smoking may now be considered an "established" risk factor for Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease. The findings come from Baystate Medical Center neurologist Dr. (Source: Muscular Dystrophy News From Medical News Today)
Source: Muscular Dystrophy News From Medical News Today - November 17, 2009 Category: Neurology Tags: Smoking / Quit Smoking Source Type: news
Neuropathology of Olfactory Ensheathing Cell Transplantation into the Brain of Two Amyotrophic Lateral Sclerosis (ALS) PatientsEmail this article to a colleague.
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In conclusion, the present neuropathologic analysis does not support a beneficial effect of fetal OEC implantation into the frontal lobes of ALS patients. (Source: Brain Pathology)
Source: Brain Pathology - November 17, 2009 Category: Neurology Authors: Maria Teresa Giordana, Silvia Grifoni, Barbara Votta, Michela Magistrello, Marco Vercellino, Alessia Pellerino, Roberto Navone, Consuelo Valentini, Andrea Calvo, Adriano Chiò Source Type: journals
Lower serum lipid levels are related to respiratory impairment in patients with ALSEmail this article to a colleague.
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Conclusion: Our findings do not support the observation that patients with amyotrophic lateral sclerosis have hyperlipidemia or that hyperlipidemia in this population is related to longer survival. However, some evidence emerged that respiratory impairment, but not a worse clinical status or a lower body mass index, is related to a decrease in blood lipids and LDL/HDL ratio. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Chio, A., Calvo, A., Ilardi, A., Cavallo, E., Moglia, C., Mutani, R., Palmo, A., Galletti, R., Marinou, K., Papetti, L., Mora, G. Tags: amyotrophic lateral sclerosis ARTICLES Source Type: journals
Study of 962 patients indicates progressive muscular atrophy is a form of ALSEmail this article to a colleague.
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Conclusion: Although patients with progressive muscular atrophy (PMA) tended to live longer than those with amyotrophic lateral sclerosis (ALS), shorter survival in PMA is associated with the same risk factors that predict poor survival in ALS. Additionally, PMA is relentlessly progressive, and UMN involvement can occur, as also reported in imaging and postmortem studies. For these reasons, PMA should be considered a form of ALS. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Kim, W. -K., Liu, X., Sandner, J., Pasmantier, M., Andrews, J., Rowland, L. P., Mitsumoto, H. Tags: MRS, Anterior nerve cell disease, amyotrophic lateral sclerosis, Class III, Cohort studies ARTICLES Source Type: journals
Smoking may be considered an established risk factor for sporadic ALSEmail this article to a colleague.
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Conclusions: Smoking may be considered an established risk factor for sporadic amyotrophic lateral sclerosis (ALS) (level A rating; 3 class II studies, 1 class III study). Evidence-based analysis of epidemiologic data shows concordance among results of better-designed studies linking smoking to ALS, and lets those results drive the conclusions. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Armon, C. Tags: amyotrophic lateral sclerosis, Risk factors in epidemiology VIEWS AND REVIEWS Source Type: journals
Smoking may now be considered an established risk factor for ALS, also known as Lou Gehrig's DiseaseEmail this article to a colleague.
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(Baystate Medical Center) While previous studies have indicated a "probable" connection between smoking and ALS, a new study published in the Nov. 17, 2009, issue of Neurology, the medical journal of the American Academy of Neurology, states that smoking may now be considered an "established" risk factor for amyotrophic lateral sclerosis, also known as Lou Gehrig's disease. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 16, 2009 Category: Global & Universal Source Type: news
Does neuroinflammation fan the flame in neurodegenerative diseases?Email this article to a colleague.
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While peripheral immune access to the central nervous system (CNS) is restricted and tightly controlled, the CNS is capable of dynamic immune and inflammatory responses to a variety of insults. Infections, trauma, stroke, toxins and other stimuli are capable of producing an immediate and short lived activation of the innate immune system within the CNS. This acute neuroinflammatory response includes activation of the resident immune cells (microglia) resulting in a phagocytic phenotype and the release of inflammatory mediators such as cytokines and chemokines. While an acute insult may trigger oxidative and nitrosative str...
Source: Molecular Neurodegeneration - November 16, 2009 Category: Neurology Authors: Tamy Frank-CannonLaura AltoFiona McAlpineMalu Tansey Source Type: journals
Call for Entries: Submit Your Short Video to the Neuro Film FestivalEmail this article to a colleague.
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One in six Americans is affected by a brain disorder such as Alzheimer's disease, migraine, autism, MS, Parkinson's disease, epilepsy, ALS, stroke, and more. Make a film telling us your story, or the story of a loved one, affected by a brain disorder. Help us make the case for why more brain research is needed to find cures. Win Up to $1,500 in Prizes Eligible entries could win up to $1,500 in prizes. You don't have to be an expert filmmaker to share your story. Learn more about contest rules and guidelines and judging criteria. DEADLINE: February 16, 2010
Contest Prizes Three prizes are offered for different audien...
Source: ScanGrants feed - November 16, 2009 Category: Research Authors: American Academy of Neurology Source Type: funding
Tesco Takes The Biscuit For Charity - Muscular Dystrophy Campaign, UKEmail this article to a colleague.
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Tesco customers are being asked to get dunking to raise at least £1,500 for children with muscle-wasting diseases. The retailer has created this limited edition biscuit exclusively to raise funds for the Muscular Dystrophy Campaign, Tesco Charity of the Year 2009. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 15, 2009 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news
Statement On The Baby RB Case - Muscular Dystrophy CampaignEmail this article to a colleague.
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A baby with a rare neuromuscular condition who has been on a ventilator in hospital since birth, known for legal reasons as Baby RB, has been at the centre of a legal debate between his parents - a debate which has now ended with the baby's father withdrawing his objections to the ventilator being switched off. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 15, 2009 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news
Statement On The Baby RB Case - Muscular Dystrophy CampaignEmail this article to a colleague.
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A baby with a rare neuromuscular condition who has been on a ventilator in hospital since birth, known for legal reasons as Baby RB, has been at the centre of a legal debate between his parents - a debate which has now ended with the baby's father withdrawing his objections to the ventilator being switched off. He was born with congenital myasthenic syndrome, a muscle weakness that limits the movement of his limbs and his ability to breathe on his own. (Source: Muscular Dystrophy News From Medical News Today)
Source: Muscular Dystrophy News From Medical News Today - November 15, 2009 Category: Neurology Tags: Muscular Dystrophy / ALS Source Type: news
Tesco Takes The Biscuit For Charity - Muscular Dystrophy Campaign, UKEmail this article to a colleague.
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Tesco customers are being asked to get dunking to raise at least £1,500 for children with muscle-wasting diseases. The retailer has created this limited edition biscuit exclusively to raise funds for the Muscular Dystrophy Campaign, Tesco Charity of the Year 2009. (Source: Muscular Dystrophy News From Medical News Today)
Source: Muscular Dystrophy News From Medical News Today - November 15, 2009 Category: Neurology Tags: Muscular Dystrophy / ALS Source Type: news
Massachusetts Towns Move Forward with Regional Paramedic Service - JEMS.comEmail this article to a colleague.
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Bedford, Mass. - Since 1982, Emerson Hospital has provided advanced life support (ALS) service to Lincoln and 12 other area communities. But with the hospital phasing out the program in the next year due... (Source: JEMS Latest News)
Source: JEMS Latest News - November 13, 2009 Category: Emergency Medicine Source Type: news
DEGAM-SymposiumEmail this article to a colleague.
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Einführung: Am 16./17. Januar 2009 fand in Bonn auf dem Hintergrund der universitären Lehrverpflichtungen der erste akademische Seminarkongress Forschung und Lehre für Naturheilverfahren (NHV) und Komplementärmedizin (CAM) statt. Der Kongress war konzipiert als Arbeitstagung für deutschsprachige Hochschullehrer/Dozenten für NHV/CAM zusammen mit Forschern und interessierten Studierenden.Methoden: Plenarbeiträge beschränkten sich beim Kongress auf eine Impulsfunktion. In thematisch zugeordneten, fachlich moderierten und mitprotokollierten Arbeitsgruppen wurden die Impulse weiterbearbeitet. Die Arbeitsgruppen von 6–...
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: D. Jobst Source Type: journals
South Florida Man Inspires 'Ian's Law'Email this article to a colleague.
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McClatchy/The Miami Herald reports on Ian Pearl, a South Florida man born with muscular dystrophy who is drawing attention to discriminatory health insurance practices against the disabled. (Source: Public Health News From Medical News Today)
Source: Public Health News From Medical News Today - November 12, 2009 Category: Primary Care Tags: Muscular Dystrophy / ALS Source Type: news
Treatment To Improve Degenerating Muscle Gains StrengthEmail this article to a colleague.
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A study appearing in Science Translational Medicine puts scientists one step closer to clinical trials to test a gene delivery strategy to improve muscle mass and function in patients with certain degenerative muscle disorders. Severe weakness of the quadriceps is a defining feature of several neuromuscular disorders. (Source: Genetics News From Medical News Today)
Source: Genetics News From Medical News Today - November 12, 2009 Category: Genetics & Stem Cells Tags: Muscular Dystrophy / ALS Source Type: news
Treatment To Improve Degenerating Muscle Gains StrengthEmail this article to a colleague.
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A study appearing in Science Translational Medicine puts scientists one step closer to clinical trials to test a gene delivery strategy to improve muscle mass and function in patients with certain degenerative muscle disorders. Severe weakness of the quadriceps is a defining feature of several neuromuscular disorders. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 12, 2009 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news
South Florida Man Inspires 'Ian's Law'Email this article to a colleague.
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McClatchy/The Miami Herald reports on Ian Pearl, a South Florida man born with muscular dystrophy who is drawing attention to discriminatory health insurance practices against the disabled. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 12, 2009 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news
MDA Grantees Prove Gene Therapy Grows Muscle Strength & Size In PrimatesEmail this article to a colleague.
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Four macaque monkeys that received injections of genes for a protein called follistatin into upper leg muscles experienced pronounced and durable increases in muscle size and strength and no adverse effects, the Muscular Dystrophy Association (MDA) announced. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 12, 2009 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news
MDA Grantees Prove Gene Therapy Grows Muscle Strength & Size In PrimatesEmail this article to a colleague.
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Four macaque monkeys that received injections of genes for a protein called follistatin into upper leg muscles experienced pronounced and durable increases in muscle size and strength and no adverse effects, the Muscular Dystrophy Association (MDA) announced. The findings could have implications particularly for injured and aging people worldwide; and for tens of millions experiencing muscle loss associated with cancer, AIDs and muscle diseases. (Source: Muscular Dystrophy News From Medical News Today)
Source: Muscular Dystrophy News From Medical News Today - November 12, 2009 Category: Neurology Tags: Muscular Dystrophy / ALS Source Type: news
Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS.Email this article to a colleague.
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Exposure to environmental lead (Pb) is a mild risk factor for Amyotrophic Lateral Sclerosis (ALS), a paralytic disease characterized by progressive degeneration of motor neurons. However, recent evidence has paradoxically linked higher Pb levels in ALS patients with longer survival. We investigated the effects of low-level Pb exposure on survival of mice expressing the ALS-linked superoxide dismutase-1 G93A mutation (SOD1(G93A)). SOD1(G93A) mice exposed to Pb showed longer survival and increased expression of VEGF in the ventral horn associated with reduced astrocytosis. Pretreatment of cultured SOD1(G93A) astrocytes w...
Source: Neurobiology of Disease - November 12, 2009 Category: Neurology Authors: Barbeito AG, Martinez-Palma L, Vargas MR, Pehar M, Mañay N, Beckman JS, Barbeito L, Cassina P Tags: Neurobiol Dis Source Type: journals
Vocal Cord Dysfunction in Amyotrophic Lateral Sclerosis: Four Cases and a Review of the Literature [Neurological Review]Email this article to a colleague.
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We describe 4 patients with amyotrophic lateral sclerosis (ALS) and glottic narrowing due to vocal cord dysfunction, and review the literature found using the following search terms: amyotrophic lateral sclerosis, motor neuron disease, stridor, laryngospasm, vocal cord abductor paresis, and hoarseness. Neurological literature rarely reports vocal cord dysfunction in ALS, in contrast to otolaryngology literature (4%-30% of patients with ALS). Both infranuclear and supranuclear mechanisms may play a role. Vocal cord dysfunction can occur at any stage of disease and may account for sudden death in ALS. Treatment of severe cas...
Source: Archives of Neurology - November 9, 2009 Category: Neurology Authors: van der Graaff, M. M., Grolman, W., Westermann, E. J., Boogaardt, H. C., Koelman, H., van der Kooi, A. J., Tijssen, M. A., de Visser, M. Tags: Neurology, amyotrophic lateral sclerosis, Motor Neuron Disease, Neuromuscular diseases, Neurology, Other, Otolaryngology/ Head & Neck Surgery, Voice Disorders, Pulmonary Diseases, Pulmonary Diseases, Other, Review Neurological Review Source Type: journals
Survival Profiles of Patients With Frontotemporal Dementia and Motor Neuron Disease [Original Contribution]Email this article to a colleague.
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Conclusions Distinct patterns of survival profiles exist in patients with frontotemporal dementia and motor neuron disease, and overall survival may depend on the relative timing of the emergence of secondary symptoms. (Source: Archives of Neurology)
Source: Archives of Neurology - November 9, 2009 Category: Neurology Authors: Hu, W. T., Seelaar, H., Josephs, K. A., Knopman, D. S., Boeve, B. F., Sorenson, E. J., McCluskey, L., Elman, L., Schelhaas, H. J., Parisi, J. E., Kuesters, B., Lee, V. M.-Y., Trojanowski, J. Q., Petersen, R. C., van Swieten, J. C., Grossman, M. Tags: Neurology, amyotrophic lateral sclerosis, Cognitive Disorders, Dementias, Neurogenetics, Motor Neuron Disease, Neuromuscular diseases, Neurology, Other, Prognosis/ Outcomes Original Contribution Source Type: journals
What Is Really New in Progressive Muscle Atrophy? [Correspondence]Email this article to a colleague.
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(Source: Archives of Neurology)
Source: Archives of Neurology - November 9, 2009 Category: Neurology Authors: de Carvalho, M., Swash, M. Tags: Neurology, amyotrophic lateral sclerosis, Motor Neuron Disease, Neuromuscular diseases, Neurology, Other Correspondence Source Type: journals
What Is Really New in Progressive Muscle Atrophy?--Reply [Correspondence]Email this article to a colleague.
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(Source: Archives of Neurology)
Source: Archives of Neurology - November 9, 2009 Category: Neurology Authors: Van den Berg-Vos, R. M. Tags: Neurology, amyotrophic lateral sclerosis, Motor Neuron Disease, Neuromuscular diseases, Neurology, Other Correspondence Source Type: journals
North East MP Takes Fight For Muscle Disease Patients To The CommonsEmail this article to a colleague.
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MP Dave Anderson fought for better services for children and adults with neuromuscular conditions during a House of Commons debate when he called for "real improvements throughout the country" for patients earlier this week. Mr Anderson, the Chair of the All Party Parliamentary Group for Muscular Dystrophy also met with ministers and peers to look forward to the launch of a new investigation and subsequent report into wheelchair provision for people with muscle disease. (Source: Muscular Dystrophy News From Medical News Today)
Source: Muscular Dystrophy News From Medical News Today - November 9, 2009 Category: Neurology Tags: Muscular Dystrophy / ALS Source Type: news
North East MP Takes Fight For Muscle Disease Patients To The CommonsEmail this article to a colleague.
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MP Dave Anderson fought for better services for children and adults with neuromuscular conditions during a House of Commons debate when he called for "real improvements throughout the country" for patients earlier this week. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 9, 2009 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news
Post-transcriptional control of neurofilaments: New roles in development, regeneration and neurodegenerative disease.Email this article to a colleague.
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Neurofilament (NF) protein expression is coupled to axon development and the maintenance of neuronal homeostasis. Here, we present evidence that this tight regulation depends critically on post-transcriptionally regulated changes in NF mRNA transport, translation and stability. Recent studies have shown that post-transcriptional mechanisms modulate increases in NF gene transcription during axon regeneration to yield the final pattern of NF protein expression. Other recent work has found that post-transcriptional control of NFs shares elements with that of other axonal proteins and that its dysregulation contributes to ...
Source: Trends in Neurosciences - November 9, 2009 Category: Neuroscience Authors: Szaro BG, Strong MJ Tags: Trends Neurosci Source Type: journals
Possible Help In Fight Against Muscle-wasting DiseaseEmail this article to a colleague.
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A compound already used to treat pneumonia could become a new therapy for an inherited muscular wasting disease, according to researchers at the University of Oregon and the University of Rochester School of Medicine and Dentistry in New York. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 8, 2009 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news
Possible Help In Fight Against Muscle-wasting DiseaseEmail this article to a colleague.
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A compound already used to treat pneumonia could become a new therapy for an inherited muscular wasting disease, according to researchers at the University of Oregon and the University of Rochester School of Medicine and Dentistry in New York. (Source: Muscular Dystrophy News From Medical News Today)
Source: Muscular Dystrophy News From Medical News Today - November 8, 2009 Category: Neurology Tags: Muscular Dystrophy / ALS Source Type: news
Possible Help In Fight Against Muscle Wasting DiseaseEmail this article to a colleague.
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A compound already used to treat pneumonia could become a new therapy for an inherited muscular wasting disease, according to researchers at the University of Oregon and the University of Rochester School of Medicine and Dentistry in New York. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 7, 2009 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news
Possible Help In Fight Against Muscle Wasting DiseaseEmail this article to a colleague.
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A compound already used to treat pneumonia could become a new therapy for an inherited muscular wasting disease, according to researchers at the University of Oregon and the University of Rochester School of Medicine and Dentistry in New York. (Source: Muscular Dystrophy News From Medical News Today)
Source: Muscular Dystrophy News From Medical News Today - November 7, 2009 Category: Neurology Tags: Muscular Dystrophy / ALS Source Type: news
Bistable twisted-bend and twisted-nematic liquid crystal displayEmail this article to a colleague.
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Y. W. Li and H. S. Kwok Bistability of twisted-bend and twisted configuration is found. It is based on the elastic and topological inequivalency of director orientation. Multiple states of minimum local energy exist, with appropriate boundary conditions. The effects of elastic constants, d/P ratio and pretilt angle are als ... [Appl. Phys. Lett. 95, 181107 (2009)] published Thu Nov 5, 2009. (Source: Applied Physics Letters)
Source: Applied Physics Letters - November 6, 2009 Category: Physics Source Type: journals
Analysis of time course (1)H NMR metabolomics data by multivariate curve resolution.Email this article to a colleague.
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Modeling NMR-based metabolomics data often involves linear methods such as principal component analysis (PCA) and partial least squares (PLS). These methods have the objective of describing the main variance in the data and maximum covariance between the predictor variables and some response variable respectively. If the experiment is designed to investigate temporal biological fluctuations, however, the factors obtained become difficult to interpret in a biological context. Moreover, when these methods are applied to analyze data, an implicit assumption is made that the measurement errors exhibit an iid-normal distrib...
Source: Magnetic Resonance in Chemistry : MRC - November 6, 2009 Category: Chemistry Authors: Karakach TK, Knight R, Lenz EM, Viant MR, Walter JA Tags: Magn Reson Chem Source Type: journals
Puusepp's sign—Clinical significance of a forgotten pyramidal signEmail this article to a colleague.
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Abstract: The pyramidal signs in the lower extremity can be divided into three groups: (1) Babinski's group characterised by dorsoflexion of the great toe, (2) pyramidal signs marked by plantar flexion of the toes (e.g. Rossolimo's sign), and (3) synkinetic movements such as Strümpell's phenomenon. Puusepp's sign described by the Estonian neurologist and neurosurgeon Ludvig Puusepp belongs to none of these three groups. Its eliciting does not differ from that of Babinski's sign. The response, however, is different and consists of a tonic slow abduction of the little toe. We showed its relevance on the basis of clinical ex...
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Pawel Tacik, M. Krasnianski, S. Zierz Tags: Letters to the Editor Source Type: journals
Cervical spondylotic amyotrophy presenting as dropped head syndromeEmail this article to a colleague.
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We report a case of acute-onset dropped head syndrome in a 65-year-old patient in whom the diagnosis of amyotrophic lateral sclerosis (ALS) was initially proposed based on electromyographic signs of neck and shoulder muscle denervation. There were no signs of pyramidal involvement and the clinical and electromyographic signs of motor denervation never evolved beyond the neck and shoulder girdle muscles after a 6-year follow-up period, which argued against ALS. Other causes of dropped head syndrome were carefully ruled out based on clinical findings, electrodiagnostic studies and blood investigations. The restriction of mus...
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Rechdi Ahdab, Alain Créange, Sandrine Benaderette, Jean-Pascal Lefaucheur Tags: Case reports Source Type: journals
Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice.Email this article to a colleague.
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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons (MNs). The molecular pathogenesis of ALS is not understood, thus effective therapies for this disease are lacking. Some forms of ALS are inherited by mutations in the superoxide dismutase-1 (SOD1) gene. Transgenic mice expressing human Gly93 --> Ala (G93A) mutant SOD1 (mSOD1) develop severe MN disease, oxidative and nitrative damage, and mitochondrial pathology that appears to involve nitric oxide-mediated mechanisms. We used G93A-mSOD1 mice to test the hypothesis that the degeneration of MNs is associated with an aberrant up-r...
Source: Brain Structure and Function - November 4, 2009 Category: Neuroscience Authors: Chen K, Northington FJ, Martin LJ Tags: Brain Struct Funct Source Type: journals
