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Frequency of antibodies against the etiologic agents of acquired imunodeficiency syndrome, syphilis, hepatitis B and C, and Chagas' disease in patients with rheumatic diseases treated with anti-tumor necrosis factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The frequency of seropositivity for different infectious diseases in patients under anti-TNF therapy is low. Individuals with positive serology for hepatitis C deserve close attention. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals

Pulmonary fungal infection with hyalohyphomycosis associated with zygomycosis and Actinomyces spp. in a patient with ankylosing spondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A espondilite anquilosante (EA) pode cursar com manifestações extra-articulares e, dentre elas, as pulmonares. A fibrose nos ápices pulmonares ocorre em até 30% dos casos e as formações císticas são menos frequentes e observadas em casos avançados. A colonização dessas cavidades é uma complicação rara. Um paciente com diagnóstico de EA desde 1998, com comprometimento axial, histórico de tuberculose pulmonar tratada em 2002 e 2007, evoluiu com um quadro de aspergilose bilateral em ápices pulmonares associada à zigomicose e Actinomyces spp. Havia sido internado para investigar queixa de emagrecimento, sudor...
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals

ErrataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A espondilite anquilosante (EA) pode cursar com manifestações extra-articulares e, dentre elas, as pulmonares. A fibrose nos ápices pulmonares ocorre em até 30% dos casos e as formações císticas são menos frequentes e observadas em casos avançados. A colonização dessas cavidades é uma complicação rara. Um paciente com diagnóstico de EA desde 1998, com comprometimento axial, histórico de tuberculose pulmonar tratada em 2002 e 2007, evoluiu com um quadro de aspergilose bilateral em ápices pulmonares associada à zigomicose e Actinomyces spp. Havia sido internado para investigar queixa de emagrecimento, sudor...
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals

Infliximab and anterior optic neuropathy: case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion It is important to consider the possibility of anterior optic neuropathy, in addition to retrobulbar optic neuritis, in patients who experience sudden-onset visual loss while being treated with infliximab. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00417-009-1227-yAuthors Jane W. Chan, University of Kentucky College of Medicine Department of Neurology and Ophthalmology KY Clinic L-445 Lexington KY 40536 USAAlberto Castellanos, Central Baptist Hospital Department of Internal Medicine Lexington KY 40503 USA Journal Graefe's Archive for Clinical and Experimental Ophthal...
Source: Graefe's Archive for Clinical and Experimental Ophthalmology - November 16, 2009 Category: Opthalmology Tags: Graefe's Archive for Clinical and Experimental Ophthalmology Source Type: journals

Surgical Outcome After Spinal Fractures in Patients With Ankylosing SpondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A recent study presents the surgical experience of spinal fractures in patients with ankylosing spondylitis and highlights the difficulties that exist regarding diagnosis and surgical management. BMC Musculoskeletal Disorders (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 16, 2009 Category: Consumer Health News Tags: Orthopaedics Source Type: news

Agreement Between Quantiferon-TB Gold Test and Tuberculin Skin Test in the Identification of Latent Tuberculosis Infection in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The comparable prevalence of LTBI among the study groups according to QTF-G supports the view that QTF-G is less susceptible to external factors than TST. Sequential testing for QTF-G in patients with indeterminate or negative results may also be helpful in discriminating LTBI better. PMID: 19918035 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 16, 2009 Category: Rheumatology Authors: Inanc N, Aydin SZ, Karakurt S, Atagunduz P, Yavuz S, Direskeneli H Tags: J Rheumatol Source Type: journals

HLA-E gene polymorphism associates with ankylosing spondylitis in SardiniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: There is a strong association between the presence of a haplotype in genes mapping between HLA-E and HLA-C and AS due to an increase of homozygous markers in patients. The strongest association however, is with the HLA-E functional polymorphism rs1264457. Since HLA-E is the ligand for the NKG2A receptor, these data point to the natural killer (NK) activity as possible player in the pathogenesis of AS. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 13, 2009 Category: Rheumatology Authors: Fabiana PaladiniFrancesca BelfioreElisa CoccoCarlo CarcassiAlberto CauliAlessandra VaccaMaria Teresa FiorilloAlessandro MathieuIsabella CascinoRosa Sorrentino Source Type: journals

Adalimumab safety and mortality rates from global clinical trials of six immune-mediated inflammatory diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Based on 10 years of clinical trial experience across six diseases, this safety report and the established efficacy of adalimumab in these diseases provide the foundation for a better understanding of its benefit–risk profile. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - November 12, 2009 Category: Rheumatology Authors: Burmester, G R, Mease, P, Dijkmans, B A C, Gordon, K, Lovell, D, Panaccione, R, Perez, J, Pangan, A L Tags: Unlocked, Immunology (including allergy), ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology, Calcium and bone Clinical and epidemiological research Source Type: journals

ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The ASDAS is a validated, highly discriminatory instrument for assessing disease activity in AS, including patient-reported outcomes and CRP levels. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - November 12, 2009 Category: Rheumatology Authors: van der Heijde, D, Lie, E, Kvien, T K, Sieper, J, Van den Bosch, F, Listing, J, Braun, J, Landewe, R, for the Assessment of SpondyloArthritis international Society (ASAS) Tags: Immunology (including allergy), Pain (neurology), ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Clinical and epidemiological research Source Type: journals

Ankylosing spondylitis and the risk of fracture: results from a large primary care-based nested case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients with AS have an increased risk of clinical vertebral fracture but not of non-vertebral fractures, while the risk of any clinical fracture is increased in patients with concomitant inflammatory bowel disease. The mechanism by which non-steroidal anti-inflammatory drugs reduce the risk of any clinical fracture warrants further research. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - November 12, 2009 Category: Rheumatology Authors: Vosse, D, Landewe, R, van der Heijde, D, van der Linden, S, van Staa, T-P, Geusens, P Tags: Inflammatory bowel disease, Immunology (including allergy), Pain (neurology), ankylosing spondylitis, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoi Source Type: journals

Reliability of high-resolution ultrasonography in the assessment of Achilles tendon enthesopathy in seronegative spondyloarthropathiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: US assessment of Achilles tendon enthesopathy in patients with SpA, using the OMERACT preliminary definition, was found to be reliable. Bone irregularity and entheseal hypoechogenicity were the most difficult abnormalities to reach agreement on. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - November 12, 2009 Category: Rheumatology Authors: Filippucci, E, Aydin, S Z., Karadag, O, Salaffi, F, Gutierrez, M, Direskeneli, H, Grassi, W Tags: Immunology (including allergy), Inflammation, Radiology, ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics), Calcium and bone Source Type: journals

The use of tumour necrosis factor alpha-blockers in daily routine. An Austrian consensus projectEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To define relevant disease parameters and their respective limits indicating the initiation of TNF-α-blockers in individual patients. Subsequently, to analyze retrospectively patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) or ankylosing spondylitis (AS), who started TNF-α inhibition in 2006. Points to consider, regarded relevant for individual treatment decisions as well as their assessment methods, were ascertained by experts’ consensus applying the Delphi technique. Subsequently, these parameters’ thresholds with respect to the initiation of a TNF-α-blocker were identifie...
Source: Clinical Rheumatology - November 10, 2009 Category: Rheumatology Tags: Clinical Rheumatology Source Type: journals

Insights into the pathogenesis of axial spondyloarthropathy based on gene expression profilesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study tested the hypothesis that SpA is characterized by a distinct pattern of gene expression in peripheral blood of affected individuals compared with healthy controls. Methods: High-density, human GeneChip(R) probe arrays (HG-U133 plus 2.0, Affymetrix, Inc.) were used to profile mRNA of peripheral blood cells from 18 subjects with SpA and 25 normal individuals. Samples were processed as two separate sets at different times (11 SpA + 12 control subjects in primary set (Set 1); 7 SpA+ 13 control subjects in the validation set (Set 2)). Blood samples were taken at a time when patients were not receiving systemic immun...
Source: BioMed Central - November 9, 2009 Category: Journals (General) Authors: Srilakshmi SharmaDongseok ChoiStephen PlanckChristina HarringtonCarrie AustinJinnell LewisTessa DiebelTammy MartinJustine SmithJames Rosenbaum Source Type: journals

The silent progression of metastatic malignancy during the treatment with soluble tumor necrosis factor receptorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Etanercept is singular among anti-tumor necrosis factor alpha (TNF-α) agents, for being a soluble antibody to both TNF and lymphtoxin-alpha. The long-term neutralization of two cachexins by etanercept would theoretically compromise early detection of malignancy. This case reports a patient who was treated by etanercept for 21 months due to ankylosing spondylitis. Metastatic malignancy of unknown origin developed, and silently led the patient to lethal hepatic rupture. With an example of a malignancy masking effect of soluble TNF receptor, this article questions a need for vigilant attention to...
Source: Clinical Rheumatology - November 6, 2009 Category: Rheumatology Tags: Clinical Rheumatology Source Type: journals

Ankylosing Spondylitis - Knee, Hip and Spine PainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Information on Ankylosing Spondylitis a chronic inflammatory arthritis and autoimmune disease affecting spinal joints and causing eventual fusion of the spine. (Source: Disabled World)
Source: Disabled World - November 5, 2009 Category: Disability Tags: Autoimmune Diseases Source Type: info

Ankylosing spondylitis has 'substantial impact' on sex lifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
People with ankylosing spondylitis often find that their disease has a major impact on their sexual relationships, according to a new study carried out by the Arthritis Research Campaign National Primary Care Centre at Keele University. (Source: Arthritis Research Campaign)
Source: Arthritis Research Campaign - November 5, 2009 Category: Rheumatology Authors: Arthritis Research Campaign (mailto:info at arc.org.uk) Source Type: news

IL-23 and IL-17 in ankylosing spondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00296-009-1226-7Authors Daniel Wendling, University Teaching Hospital Department of Rheumatology Boulevard Fleming 25030 Besançon France Journal Rheumatology InternationalOnline ISSN 1437-160XPrint ISSN 0172-8172 (Source: Rheumatology International)
Source: Rheumatology International - November 4, 2009 Category: Rheumatology Tags: Rheumatology International Source Type: journals

Pattern of Disease Onset, Diagnostic Delay, and Clinical Features in Juvenile Onset and Adult Onset Ankylosing Spondylitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: JOAS and AOAS had distinctive courses and Turkish patients with AS had similar features compared to other Caucasian patient populations. PMID: 19884272 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 2, 2009 Category: Rheumatology Authors: Ozgocmen S, Ardicoglu O, Kamanli A, Kaya A, Durmus B, Yildirim K, Baysal O, Gur A, Karatay S, Altay Z, Cevik R, Erdal A, Ersoy Y, Sarac AJ, Tekeoglu I, Ugur M, Nas K, Senel K, Ulusoy H Tags: J Rheumatol Source Type: journals

Cardiovascular involvement of ankylosing spondylitis: report of three cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiovascular involvement is one of the extra-articular manifestations of ankylosing spondylitis. Of these, aortic disease and aortic regurgitation are the most commonly associated cardiovascular disorders. Since 2005, three male patients with ankylosing spondylitis were referred to The Chaim Sheba Medical Center for surgical treatment of cardiovascular associations. The diagnosis of ankylosing spondylitis was evidenced by radiography and/or laboratory tests of C-reactive protein or HLA-B27. Apart from the usual cardiac manifestations including heart block and left ventricular hypertrophy, usual associated disorders s...
Source: Vascular - November 1, 2009 Category: Surgery Authors: Yuan SM Tags: Vascular Source Type: journals

No association of KIR3DL1 or KIR3DS1 or their alleles with ankylosing spondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We determined the alleles of KIR3DL1 and KIR3DS1 in a cohort of British Caucasian ankylosing spondylitis (AS) patients and HLA-B27-positive controls. We found no association in frequencies of the alleles of these genes in AS. In addition, no differences were found when the patients and controls were differentiated by gender. (Source: Tissue Antigens)
Source: Tissue Antigens - October 29, 2009 Category: Allergy & Immunology Authors: J. McCappin, D. Harvey, B. P. Wordsworth, D. Middleton Source Type: journals

Progress in Studies of the Genetics of Ankylosing SpondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The advent of high throughput SNP genotyping methods has advanced research into the genetics of common complex genetic diseases such as ankylosing spondylitis rapidly in recent times. The identification of associations with the genes IL23R and ERAP1 have been robustly replicated, and advances have been made in studies of the MHC genetics of AS, and of KIR gene variants and the disease. The findings are already being translated into increased understanding of the immunological pathways involved in AS, and raising novel potential therapies. The IL23R findings and subsequent immunological investigations suggest that targeted ...
Source: Arthritis Research and Therapy - October 29, 2009 Category: Rheumatology Authors: Matthew Brown Source Type: journals

Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Osteocytes are considered to be sensors of bone damage and regulators of bone mass by specifically expressing sclerostin, an inhibitor of bone formation. The contribution of osteocytes in regulating local bone remodeling in arthritis is unknown. The aim of this study was to investigate the role of osteocytes as contributors to bone remodeling in ankylosing spondylitis (AS).Sclerostin expression and osteocyte death were assessed by immunohistochemistry in joints derived from patients with AS, patients with rheumatoid arthritis (RA), and patients with osteoarthritis (OA), as well as from control subjects. In addition, the se...
Source: Arthritis and Rheumatism - October 29, 2009 Category: Rheumatology Authors: Heiner Appel, Gisela Ruiz-Heiland, Joachim Listing, Jochen Zwerina, Martin Herrmann, Ruediger Mueller, Hildrun Haibel, Xenofon Baraliakos, Axel Hempfing, Martin Rudwaleit, Joachim Sieper, Georg Schett Tags: Spondylarthritis Source Type: journals

Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The results of a recent genome-wide association study have shown that ERAP1 and IL23R are associated with ankylosing spondylitis (AS) in Caucasian populations from North America and the UK. Based on these findings, we undertook the current study to investigate whether single-nucleotide polymorphisms (SNPs) covering the genes ERAP1 and IL23R are associated with AS in a Han Chinese population.A case-control study was performed in Han Chinese patients with AS (n = 527) and controls (n = 945) from Shanghai and Nanjing. All patients met the modified New York criteria for AS. The Sequenom iPlex platform was used to genotype case...
Source: Arthritis and Rheumatism - October 29, 2009 Category: Rheumatology Authors: Stuart I. Davidson, Xin Wu, Yu Liu, Meng Wei, Patrick A. Danoy, Gethin Thomas, Qing Cai, Linyun Sun, Emma Duncan, Niansong Wang, Qinghong Yu, Anlong Xu, Yonggui Fu, Matthew A. Brown, Huji Xu Tags: Spondylarthritis Source Type: journals

Identification of RGS1 as a candidate biomarker for undifferentiated spondylarthritis by genome-wide expression profiling and real-time polymerase chain reactionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To compare gene expression profiles between ankylosing spondylitis (AS) and undifferentiated spondylarthritis (uSpA) patients with inflammatory low back pain.Peripheral blood mononuclear cells (PBMCs) from patients with AS, patients with uSpA, and healthy subjects were screened using genome-wide microarrays, followed by validation by real-time polymerase chain reaction (PCR).Microarray profiling and real-time PCR assays showed only minor differences between AS patients and healthy subjects. In contrast, 20 genes were strikingly more highly expressed in uSpA patients. Regulator of G protein signaling 1 (RGS1) was identified...
Source: Arthritis and Rheumatism - October 29, 2009 Category: Rheumatology Authors: Jieruo Gu, Yu-Ling Wei, James C. C. Wei, Feng Huang, Ming-Shiou Jan, Michael Centola, Mark B. Frank, David Yu Tags: Spondylarthritis Source Type: journals

Time to prove the infective etiology of ankylosing spondylitis and related spondylarthritides: Comment on the article by Carter et alEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 29, 2009 Category: Rheumatology Authors: Henning Zeidler, Markus Rihl Tags: Letter Source Type: journals

Erythrocyte sedimentation rate, C-reactive protein level, and serum amyloid a protein for patient selection and monitoring of anti-tumor necrosis factor treatment in ankylosing spondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To study the usefulness of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum amyloid A (SAA) for response prediction and monitoring of anti-tumor necrosis factor (anti-TNF) treatment in ankylosing spondylitis (AS) patients.Patients were included consecutively before starting etanercept or infliximab treatment. ASsessment in Ankylosing Spondylitis (ASAS) response, defined as a 50% improvement or an absolute improvement of 2 points of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI; 0-10 scale), was assessed at 3 months. Inflammatory markers and the BASDAI were collected at baseline and...
Source: Arthritis Care and Research - October 29, 2009 Category: Rheumatology Authors: Mirjam K. de Vries, Izhar C. van Eijk, Irene E. van der Horst-bruinsma, Mike J. L. Peters, Michael T. Nurmohamed, Ben A. C. Dijkmans, Bouke P. C. Hazenberg, Gerrit J. Wolbink Tags: ankylosing spondylitis Source Type: journals

Progress in spondylarthritis. Progress in studies of the genetics of ankylosing spondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The advent of high-throughput SNP genotyping methods has advanced research into the genetics of common complex genetic diseases such as ankylosing spondylitis (AS) rapidly in recent times. The identification of associations with the genes IL23R and ERAP1 have been robustly replicated, and advances have been made in studies of the major histocompatibility complex genetics of AS, and of KIR gene variants and the disease. The findings are already being translated into increased understanding of the immunological pathways involved in AS, and raising novel potential therapies. The current studies in AS remain underpowered, and ...
Source: Arthritis Research and Therapy - October 29, 2009 Category: Rheumatology Authors: Matthew Brown Source Type: journals

Association of IL-1F7 gene with susceptibility to human leukocyte antigen-B27 positive Ankylosing Spondylitis in Han Chinese population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19874811 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - October 26, 2009 Category: Chemistry Authors: Pan F, Liao F, Xia G, Ge R, Mei Y, Tang X, Xu S, Xu J, Pan H, Ye D, Zou Y Tags: Clin Chim Acta Source Type: journals

Uncommon case of ankylosing spondylitis associated with spontaneous occurring hypoparathyroidismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an exceptional case of a patient with an association between ankylosing spondylitis and a severe idiopathic hypoparathyroidism with difficulties in diagnosis. To our knowledge, this is the first case of such an occurrence. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00296-009-1220-0Authors Yousra Ibn Yacoub, University Hospital of Rabat-Sale Department of Rheumatology, El Ayachi Hospital 11000 Salé MoroccoSamira Rostom, University Hospital of Rabat-Sale Department of Rheumatology, El Ayachi Hospital 11000 Salé MoroccoNajia Hajjaj-Hassouni, University Hospital of Rabat-Sale Department of R...
Source: Rheumatology International - October 23, 2009 Category: Rheumatology Tags: Rheumatology International Source Type: journals

A 2-year comparative open label randomized study of efficacy and safety of etanercept and infliximab in patients with ankylosing spondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The signs and symptoms of ankylosing spondylitis (AS) respond inadequately to nonsteroidal antiinflammatory drugs, corticosteroids, and disease modifying antirheumatic drugs in quite a number of patients. Tumor necrosis factor inhibitors have demonstrated to be of value in reducing AS disease activity in clinical trials. The efficacy and safety of both etanercept and infliximab in patients with ankylosing spondylitis were compared in a 2-year open label randomised study. Our results are consistent with a significant more rapid clinical improvement in the infliximab treated group. Treatment with both...
Source: Rheumatology International - October 22, 2009 Category: Rheumatology Tags: Rheumatology International Source Type: journals

Mannose binding lectin levels are not related to radiographic damage in ankylosing spondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In the current study we aimed to investigate the effect of MBL deficiency in radiographic damage of the spine in a large group of AS patients. One hundred and ninety-one AS patients and 85 healthy controls were studied. Disease activity, radiological scores, and demographic features were recorded. MBL levels were measured with standard ELISA kits. Results showed that median MBL levels in AS and healthy controls were 2,530 (range 0–5,861) ng/ml and 3,415 (0–7,950) ng/ml, respectively (p = 0.1). MBL deficiency (<500 ng/ml) was comparable in both groups (%21.5 in AS, % 17.6; p ...
Source: Rheumatology International - October 21, 2009 Category: Rheumatology Tags: Rheumatology International Source Type: journals

Etanercept Improves Pulmonary Capacity in Patients With Advanced Ankylosing SpondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Etanercept improves pulmonary vital capacity and spinal mobility in patients with advanced ankylosing spondylitis. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 21, 2009 Category: Consumer Health News Tags: Rheumatology Source Type: news

The colon in patients with ankylosing spondylitis and in normal controls in BangladeshEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this paper is to study the macroscopic and microscopic aspects of colonic mucosa in patients with ankylosing spondylitis (AS) and in controls without colonic symptoms in Bangladesh. This observational study was done in a tertiary care center of Dhaka. Twenty-eight consecutive cases of AS were included, fulfilling modified New York Criteria with pure axial form or combined axial and peripheral joint involvement. Ten controls were enrolled in the study from people in whom endoscopy of upper gastrointestinal tract (GI) tract was performed and who had no musculoskeletal complaints and no colonic symptoms. ...
Source: Clinical Rheumatology - October 21, 2009 Category: Rheumatology Tags: Clinical Rheumatology Source Type: journals

Original paper Open study to evaluate etidronate influence on bone markers, inflammation and RANKL/OPG system in ankylosing spondylitis (AS) patients with active inflammation. Effect of etidronate on number and metabolic activity of proinflammatory subpopulation of blood monocytes CD14+CD16+ in AS patients – a pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: 1. Etidronate has anti-resorptive and anti-inflammatory properties in men with AS. 2. There was no correlation between CRP and bone markers, sRANKL, OPG and sRANKL/OPG ratio which may suggest a lack of relationship between inflammation and bone remodeling in AS. 3. Etidronate treatment does not influence the number of proinflammatory monocytes CD14+CD16+ in peripheral blood and increases the PHA-stimulated cytokine production by peripheral blood mononuclear cells, with prevalent immunosuppressive IL-10 synthesis. (Source: Articles of Rheumatology - TERMEDIA publishing house)
Source: Articles of Rheumatology - TERMEDIA publishing house - October 19, 2009 Category: Rheumatology Source Type: journals

Standards of treatment Total hip replacement in patients with ankylosing spondylitis – rehabilitationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Total hip alloplasty in patients with ankylosing spondylitis needs specifical kinds of physiotherapy treatment. Biomechanical condition of the organism connected with typical changes in ankylosing spondylitis require to compromise in therapy between optimal, effective geit pattern and control of ankylosing process of succesive joints. Our aim was to present factors impacting the good effects of rehabilitation after surgical treatment, with special attention at early hospital period. (Source: Articles of Rheumatology - TERMEDIA publishing house)
Source: Articles of Rheumatology - TERMEDIA publishing house - October 19, 2009 Category: Rheumatology Source Type: journals

Lack of association of TNF-{alpha} promoter polymorphisms with ankylosing spondylitis: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. This meta-analysis including 2247 subjects has shown that there is a lack of association of the TNF- –308 A/G and –238 A/G polymorphisms with AS. (Source: Rheumatology)
Source: Rheumatology - October 16, 2009 Category: Rheumatology Authors: Lee, Y. H., Song, G. G. Tags: Spondylarthropathies BASIC SCIENCE Source Type: journals

Ankylosing spondylitis and its impact on sexual relationshipsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. AS has a substantial impact on patients’ sexual relationships. Management of AS and its impact on sexual relationships should be directed not only towards physical outcomes such as disease activity and physical function, but also take into consideration the psychological state of the patient. (Source: Rheumatology)
Source: Rheumatology - October 16, 2009 Category: Rheumatology Authors: Healey, E. L., Haywood, K. L., Jordan, K. P., Garratt, A. M., Ryan, S., Packham, J. C. Tags: Spondylarthropathies CLINICAL Source Type: journals

IgA nephropathy associated with ankylosing spondylitis is not controlled by infliximab therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here a case of IgA nephropathy associated with AS that became symptomatic, whereas infliximab therapy efficiently controlled the rheumatological disease. This suggests that even though infliximab therapy effectively controls rheumatological manifestations, it may not be able to prevent IgA nephropathy associated with AS. Thus, this case report illustrates the complexity of the physiopathology of both diseases. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - October 15, 2009 Category: Urology & Nephrology Authors: Jacquet, A., Francois, H., Frangie, C., Yahiaoui, Y., Ferlicot, S., Micelli, C., Mariette, X., Durrbach, A. Tags: Exceptional Case Source Type: journals

Which Aspects of Functioning Are Relevant for Patients with Ankylosing Spondylitis: Results of Focus Group Interviews.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Relevant aspects of the influence of AS are not covered by the classic disease-specific instruments. In particular, the influence of AS on socializing and leisure and the relevance of environmental and personal factors are not adequately assessed by available instruments. PMID: 19833752 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 14, 2009 Category: Rheumatology Authors: Boonen A, van Berkel M, Cieza A, Stucki G, van der Heijde D Tags: J Rheumatol Source Type: journals

Work Disability in Patients with Ankylosing Spondylitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The prevalence of permanent work disability in Spanish patients with AS is significant, and the main factors related to it are age, disease duration, structural damage, and physical functioning. Longitudinal studies are needed to confirm these results. PMID: 19833749 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 14, 2009 Category: Rheumatology Authors: Ariza-Ariza R, Hernández-Cruz B, Collantes E, Batlle E, Fernández-Sueiro JL, Gratacós J, Juanola X, Linares LF, Mulero J, Zarco P Tags: J Rheumatol Source Type: journals

Toll-like receptors and NOD-like receptors in rheumatic diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The past 10 years has seen the description of families of receptors which drive pro-inflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease - the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4 are being implicated in the pathology of rheumatoid arthritis, ankylosing spondylitis, lyme arthritis and osteoarthritis. Nalp3 has been identified as a key NLR for IL-1beta production and has been shown to have a particular role in gout. These findings present new therapeutic opportunities, possibly allowi...
Source: Arthritis Research and Therapy - October 13, 2009 Category: Rheumatology Authors: William McCormackAndrew ParkerLuke O'Neill Source Type: journals

Genetics of rheumatic diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many of the chronic inflammatory and degenerative disorders that present to the clinical rheumatologists have a complex genetic aetiology. Over the last decade there has been a dramatic improvement in technology and methodology that has accelerated the pace of gene discovery in complex disorders in an exponential fashion. In this review, we focus on rheumatoid arthritis, SLE and ankylosing spondylitis and describe some of the recently described genes that underlie these conditions and the extent to which they overlap. The next decade will witness a full account of the main disease susceptibility genes in these diseases and...
Source: Arthritis Research and Therapy - October 13, 2009 Category: Rheumatology Authors: Timothy VyseAlex Clarke Source Type: journals

Antibodies to human tissue transglutaminase and alterations of vitamin D metabolism in ankylosing spondylitis and psoriatic arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Both in ankylosing spondylitis (ASP) and psoriatic arthritis (PsA), osteopenia is present in one-third of women and men, whereas osteoporosis mainly affects men, even in their 30 s. Subclinical gut inflammation has been described in patients with AS or PsA. Joint involvement also occurs with other gastrointestinal diseases such as celiac disease. We tested the hypothesis, whether elevated serum levels of human anti-tissue-transglutaminase-IgA (htTG) are associated with changes in disease activity, vitamin D metabolism and bone mineral density (BMD) in patients with ASP and PsA. In a cross-secti...
Source: Rheumatology International - October 13, 2009 Category: Rheumatology Tags: Rheumatology International Source Type: journals

Elevated synovial expression of triggering receptor expressed on myeloid cells 1 in patients with septic arthritis or rheumatoid arthritis [Basic and translational research]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Synovial TREM-1 expression is increased in septic arthritis and RA. In patients with acute inflammatory arthritis, elevated SF sTREM-1 levels may point the clinician to a diagnosis of septic arthritis or RA. In RA patients, targeting TREM-1 may have therapeutic benefits by reducing local proinflammatory cytokine and chemokine release. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - October 12, 2009 Category: Rheumatology Authors: Collins, C E, La, D T, Yang, H-T, Massin, F, Gibot, S, Faure, G, Stohl, W Tags: Genetics, Immunology (including allergy), Inflammation, ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Rheumatoid arthritis, Calcium and bone Basic and translational research Source Type: journals

Genetic polymorphisms of the matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases-1 (TIMP-1) modulate the development of ankylosing spondylitis [Basic and translational research]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The findings highlight the importance of the MMP-3 and TIMP-1 genes as crucial elements in AS development. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - October 12, 2009 Category: Rheumatology Authors: Wei, J C-C, Lee, H-S, Chen, W-C, Shiu, L-J, Yang, S-F, Wong, R-H Tags: Genetics, Immunology (including allergy), Inflammation, ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Basic and translational research Source Type: journals

Decreased clinical response to adalimumab in ankylosing spondylitis is associated with antibody formation [Letters]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - October 12, 2009 Category: Rheumatology Authors: de Vries, M K, Brouwer, E, van der Horst-Bruinsma, I E, Spoorenberg, A, van Denderen, J C, Jamnitski, A, Nurmohamed, M T, Dijkmans, B A C, Aarden, L A, Wolbink, G J Tags: Letters Source Type: journals

Elevated synovial expression of triggering receptor expressed on myeloid cells 1 in patients with septic arthritis or rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Synovial TREM-1 expression is increased in septic arthritis and RA. In patients with acute inflammatory arthritis, elevated SF sTREM-1 levels may point the clinician to a diagnosis of septic arthritis or RA. In RA patients, targeting TREM-1 may have therapeutic benefits by reducing local proinflammatory cytokine and chemokine release. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - October 12, 2009 Category: Rheumatology Authors: Collins, C E, La, D T, Yang, H-T, Massin, F, Gibot, S, Faure, G, Stohl, W Tags: Genetics, Immunology (including allergy), Inflammation, ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Rheumatoid arthritis, Calcium and bone Basic and translational research Source Type: journals

Genetic polymorphisms of the matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases-1 (TIMP-1) modulate the development of ankylosing spondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The findings highlight the importance of the MMP-3 and TIMP-1 genes as crucial elements in AS development. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - October 12, 2009 Category: Rheumatology Authors: Wei, J C-C, Lee, H-S, Chen, W-C, Shiu, L-J, Yang, S-F, Wong, R-H Tags: Genetics, Immunology (including allergy), Inflammation, ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Basic and translational research Source Type: journals

Decreased clinical response to adalimumab in ankylosing spondylitis is associated with antibody formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - October 12, 2009 Category: Rheumatology Authors: de Vries, M K, Brouwer, E, van der Horst-Bruinsma, I E, Spoorenberg, A, van Denderen, J C, Jamnitski, A, Nurmohamed, M T, Dijkmans, B A C, Aarden, L A, Wolbink, G J Tags: Letters Source Type: journals

Comparison of the Bath Ankylosing Spondylitis Disease Activity Index and a modified version of the index in assessing disease activity in patients with ankylosing spondylitis without peripheral manifestations [Clinical and epidemiological research]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: On a group level using the mini-BASDAI did not result in an advantage to assess disease activity or in the subgroup without peripheral involvement. In only approximately 5% of AS patients was the mini-BASDAI superior to the original BASDAI. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - October 12, 2009 Category: Rheumatology Authors: Song, I H, Rudwaleit, M, Listing, J, Sieper, J Tags: Immunology (including allergy), ankylosing spondylitis, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Clinical and e Source Type: journals