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Initial Antimicrobial Therapy for Septic Shock Is Key to SurvivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The initial empiric antimicrobial therapy used to treat septic shock may be the most important determinant of whether a patient will survive to hospital discharge. Inappropriate therapy can reduce the chances of survival by fivefold or more, according to an article in the November issue of Chest. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 19, 2009 Category: Consumer Health News Tags: Critical Care Source Type: news

Malignant Ameloblastoma: A Case Report of a Recent Onset of Neck Swelling in a Patient With a Previously Treated AmeloblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 41-year-old black man presented to the Montefiore Medical Center in 1990 with a chief complaint of a “bump on my gums.” The patient reported the lesion to be of several months in duration and denied any paresthesia or pain. His medical history was significant for tuberculosis, for which he stated that he was treated with appropriate antibiotic therapy. Upon examination, an indurated expansion was noted lingual to the mandibular central incisors with intact overlying mucosa, and a periapical radiolucency was present. The radiolucency was enucleated via a standard intraoral approach, and the tissue submitted for histop...
Source: Journal of Oral and Maxillofacial Surgery - November 19, 2009 Category: ENT & OMF Authors: T. Volong Dao, Jairo A. Bastidas, Robert Kelsch, Richard A. Kraut Tags: Case Reports Source Type: journals

Principles of antibiotic therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Continuing Education in Anaesthesia, Critical Care)
Source: Continuing Education in Anaesthesia, Critical Care - November 17, 2009 Category: Anesthesiology Authors: Varley, A.J., Sule, J., Absalom, A.R. Tags: Articles Source Type: journals

The leading causes of death after burn injury in a single pediatric burn centerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IntroductionSevere thermal injury is characterized by profound morbidity and mortality. Advances in burn and critical care, including early excision and grafting, aggressive resuscitation and advances in antimicrobial therapy have made substantial contributions to decrease morbidity and mortality. Despite these advances, death still occurs. Our aim was to determine the predominant causes of death in burned pediatric patients in order to develop new treatment avenues and future trajectories associated with increased survival. Methods: Primary causes of death were reviewed from 144 pediatric autopsy reports. Percentages of p...
Source: Critical Care - November 17, 2009 Category: Intensive Care Authors: Felicia WilliamsDavid HerndonHal HawkinsJong LeeRobert CoxGabriela KulpCeleste FinnertyDavid ChinkesMarc Jeschke Source Type: journals

Clinical characteristics and outcomes of patients with vancomycin-susceptible Enterococcus faecalis and Enterococcus faecium bacteraemia—a five-year retrospective reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The purpose of this study was to assess the epidemiology and outcomes of enterococcal bacteraemia. A retrospective review of demographic, microbiological and clinical data in patients 16 years of age and over with Enterococcus faecalis or E. faecium bacteraemia at Auckland City Hospital, New Zealand, from June 2002 to May 2007 was carried out. A total of 212 patients fulfilled the inclusion criteria, with 205 being included in the analysis. E. faecalis accounted for 86% (176/205) and E. faecium 14% (29/205) of the patients. Amoxycillin resistance occurred in 69% (20/29) of E. faecium isolates. Hi...
Source: European Journal of Clinical Microbiology & Infectious Diseases - November 14, 2009 Category: Microbiology Tags: European Journal of Clinical Microbiology & Infectious Diseases Source Type: journals

Cerebrospinal fluid leakage and pneumocephalus secondary to spine stab woundsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe two cases of spinal stab wounds complicated by cerebro-spinal fluid leakage, one of them developing into severe pneumocephalus. Both patients recovered completely with the following treatment protocol: (a) trendelenburg positioning of the patient, (b) insertion of a continuous-drainage cerebro-spinal fluid catheter into the lumbar thecal sac, (c) primary suture of the leaking skin wound, (d) IV antibiotic therapy. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10195-009-0070-6Authors Nimrod Rahamimov, Western Galilee Hospital Spine Surgery Unit P.O. Box 21 Naharia 22100 IsraelHani Mulla, W...
Source: Journal of Orthopaedics and Traumatology - November 13, 2009 Category: Orthopaedics Tags: Journal of Orthopaedics and Traumatology Source Type: journals

The role of thyme in the treatment of pyodermia in newborn infants: A retrospective analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion and conclusions: Inspite of being a department with focus on complementary and integrative medicine, patients often receive systemic antibiotic treatment. Thyme is an often preferred supplement, sometimes when under clinical control even the alternative treatment.The amount of data ascertained was not large enough in order to allow making statements on the role of thyme tea as alternative or supplementary treatment, especially not in the sense of making treatment recommendations.Whether a local treatment with thyme tea might be sufficient for a subgroup of patients would have to be examined prospectively with a ...
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: M. Thiel, F. Sitzmann, A. Längler Source Type: journals

Identifying Antimicrobial Multiresistance Patterns of Escherichia coli Sampled From Diarrhoeic Calves by Cluster Analysis Techniques: A Way to Guide Research on Multiresistance MechanismsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study points out the usefulness of cluster analysis techniques to describe concisely the antimicrobial susceptibility patterns of bacterial isolates in a way that could effectively help in generating hypotheses on multiresistance mechanisms. Data were selected from the French antimicrobial resistance survey network on veterinary pathogens (Resapath). They were related to 1545 Escherichia coli isolates, which were isolated from faecal samples of diarrhoeic calves in France between 2002 and 2006. Ten clusters of isolates displaying similar features in terms of resistance profile to 13 relevant antimicrobials were comput...
Source: Zoonoses and Public Health - November 13, 2009 Category: Infectious Diseases Authors: M.-A. Botrel, E. Morignat, D. Meunier, J.-Y. Madec, D. Calavas Source Type: journals

Pharmacokinetics and Pharmacodynamics of Antibacterial AgentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews pharmacodynamics of antibacterial drugs, which can be used to optimize treatment strategies, prevent emergence of resistance and rationalize the determination of antimicrobial susceptibility. Important pharmacodynamic concepts include the requirements for bactericidal therapy for endocarditis and meningitis, for synergistic combinations to treat enterococcal endocarditis or to shorten the course of antimicrobial therapy, for obtaining maximal plasma concentration/minimal inhibitory concentration (MIC) ratios that are greater than 10 or 24 hour-area under the plasma concentration curve (AUC)/MIC ratios ...
Source: Infectious Diseases Clinics of North America - November 12, 2009 Category: Infectious Diseases Authors: Matthew E. Levison, Julie H. Levison Source Type: journals

Antibacterial Agents in the ElderlyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Older patients disproportionately suffer the burden of infection in the community and in health care facilities. The rational approach to antimicrobial therapy for older patients with infection requires an appreciation and understanding of the complex immunologic, epidemiologic, pharmacologic, and microbiologic factors that influence the manifestations and consequences of infection in this group. Specific recommendations for common infectious syndromes must take into account the unique needs of older patients and should be tailored for each individual case. (Source: Infectious Diseases Clinics of North America)
Source: Infectious Diseases Clinics of North America - November 12, 2009 Category: Infectious Diseases Authors: Stephen Weber, Emily Mawdsley, Donald Kaye Source Type: journals

Strategies and New Developments in the Management of Bacterial MeningitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The principles of antimicrobial therapy for acute bacterial meningitis include use of agents that penetrate well into cerebrospinal fluid and attain appropriate cerebrospinal fluid concentrations, are active in purulent cerebrospinal fluid, and are bactericidal against the infecting pathogen. Recommendations for treatment of bacterial meningitis have undergone significant evolution in recent years, given the emergence of pneumococcal strains that are resistant to penicillin. Clinical experience with use of newer agents is limited to case reports, but these agents may be necessary to consider in patients who are failing sta...
Source: Infectious Diseases Clinics of North America - November 12, 2009 Category: Infectious Diseases Authors: Justine Miranda, Allan R. Tunkel Source Type: journals

Streptococcus anginosus (Streptococcus milleri Group) Pyomyositis in a 50-Year-Old Man with Acquired Immunodeficiency Syndrome: Case Report and Review of LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the first reported case of bacterial pyomyositis of the right thigh caused by Streptococcus anginosus (S. milleri group) in an HIV-infected patient. The clinical presentation was complicated by multiple ring-enhancing lesions detected on magnetic resonance imaging of the brain. Evaluation for central nervous system toxoplasmosis, syphilis, and cryptococcal infection was negative. Aggressive antibiotic therapy directed against S. anginosus and surgical debridement were limb salvaging. Clinicians should consider S. anginosus as a causative pathogen in HIV-associated pyomyositis, particularly in complex presenta...
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma. A 72-year-old patient was submitted to an elective laparoscopic cholecystectomy, and a tubular adenocarcinoma in the gallbladder was incidentally diagnosed. CT scan and ultrasound before the surgery did not show any tumor. After the surgery a Pet scan was positive for a hot-spot in the left colon. The colonic lesion was conveniently removed and the histology evaluation confirmed the diagnosis of adenocarcinoma tubular. The patient was then submitted to three sections of 1,600 mg/m2 of gem...
Source: Cancer Chemotherapy and Pharmacology - November 10, 2009 Category: Cancer & Oncology Tags: Cancer Chemotherapy and Pharmacology Source Type: journals

Clinical efficacy and cost-effectiveness of outpatient parenteral antibiotic therapy (OPAT): a UK perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Using this service model, OPAT is safe and clinically effective, with low rates of complications/readmissions and high levels of patient satisfaction. OPAT is cost-effective when compared with equivalent inpatient care in the UK healthcare setting. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Chapman, A. L. N., Dixon, S., Andrews, D., Lillie, P. J., Bazaz, R., Patchett, J. D. Tags: Original research Source Type: journals

Comment on: Developments in outpatient parenteral antimicrobial therapy (OPAT) for Gram-positive infections in Europe, and the potential impact of daptomycinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Adriaenssens, N., Goossens, H., Coenen, S., on behalf of the ESAC Project Group Tags: Letter to the Editor Source Type: journals

Phase II Study of Alemtuzumab in Combination With Pentostatin in Patients With T-Cell Neoplasms [Hematologic Malignancies]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The combination of alemtuzumab and pentostatin is feasible and effective in T-cell neoplasms. Although infections, including cytomegalovirus reactivation, are a concern, they may be minimized with adequate prophylactic antibiotic therapy. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Authors: Ravandi, Aribi, O'Brien, Faderl, Jones, Ferrajoli, Huang, York, Pierce, Wierda, Kontoyiannis, Verstovsek, Pro, Fayad, Keating, Kantarjian Tags: Combined Therapy Hematologic Malignancies Source Type: journals

Enhancement effect of terpenes on silver sulphadiazine permeation through third-degree burn escharEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Antimicrobial therapy remains one of the most important methods of wound management. Systemically administered antimicrobials may not achieve therapeutic levels in wound and most agents cannot penetrate burn eschar well enough when applied topically. Therefore, we tested the notion to increase permeability of eschar toward topical agents using terpenes, a well-known class of skin permeation enhancers.Four terpenes, limonene (hydrocarbon), eucalyptol (ether), α-pinene oxide (epoxide) and geraniol (alcohol) were chosen and their effects on permeation of silver sulphadiazine (SSD), a widely used topical antimicrobi...
Source: Burns : Journal of the International Society for Burn Injuries - November 6, 2009 Category: Cosmetic Surgery Authors: Hamid R. Moghimi, Behzad S. Makhmalzadeh, Ali Manafi Tags: Articles Source Type: journals

Inappropriate Sepsis Therapy Leads To Fivefold Reduction In SurvivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients experiencing septic shock who receive inappropriate therapy may have a fivefold reduction in survival, shows a new study. Researchers from the University of Manitoba, Winnipeg, MB, Canada, retrospectively reviewed the cases of 5,715 patients with septic shock to determine the appropriateness of initial antimicrobial therapy, clinical infection site, and relevant pathogens. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 6, 2009 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

Inappropriate Sepsis Therapy Leads To Fivefold Reduction In SurvivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients experiencing septic shock who receive inappropriate therapy may have a fivefold reduction in survival, shows a new study. Researchers from the University of Manitoba, Winnipeg, MB, Canada, retrospectively reviewed the cases of 5,715 patients with septic shock to determine the appropriateness of initial antimicrobial therapy, clinical infection site, and relevant pathogens. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 6, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news

Self-Inflicted Penile Strangulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Constricting devices for the penis are used to increase the sexual performance or with autoerotic intentions. Removal of the con-stricting devices can become impossible second-ary to a hefty swelling of the penis. The treatment consists, primarily, of an immediate decompres-sion of the strangulated penis to en-sure a free blood flow and an uninhibited mic-turation. The removal of the various objects -re-quires in part craft instruments. A supplementary therapy must be selected based on existing additional complications. PMID: 19899049 [PubMed - as supplied by publisher] (Source: Aktuelle Urologie)
Source: Aktuelle Urologie - November 6, 2009 Category: Urology & Nephrology Authors: Nelius T, Filleur S Tags: Aktuelle Urol Source Type: journals

Rare association of hyper IgE syndrome with cervical rib and natal teethEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here a classical case of HIES with rare associations of natal teeth, bilateral cervical ribs, and conductive deafness. The patient was being treated with monteleukast and dapsone. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - November 5, 2009 Category: Dermatology Authors: Roshan Anupama S, Janaki C, Parveen B, Gomathy N Source Type: journals

SAPHO syndrome: is a range of pathogen-associated rheumatic diseases extended?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAPHO syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis and osteitis, is now recognized as a distinct medical entity, a reactive infectious osteitis. Genetic, immunological and bacterial mechanisms are implicated in the development of the disease. Diagnostic problems may rise due to non complete manifestations of SAPHO: acne and arthritis, or acne and anterior wall osteitis with an unclear pustulosis history. The interventional study of Assman et al. is a significant addition to a long range of publications, showing an association of SAPHO with P. acnes. Randomized control st...
Source: Arthritis Research and Therapy - November 5, 2009 Category: Rheumatology Authors: Alexander Rozin Source Type: journals

Periorbital Necrotizing Fasciitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Necrotizing fasciitis involving the periorbita is a devastating infection which potential outcomes range from severe disfigurement, loss of the eye, and even to death. Early recognition is critical though its initially nondistinctive appearance frequently delays diagnosis and treatment. Herein, the authors have performed a systematic review of previously published cases including clinical features, diagnoses and differential diagnoses, pathologic characteristics, and management. Periorbital necrotizing fasciitis is seen mainly in adults with a female predominance (54%); about half (47%) of the patients are previously h...
Source: The British Journal of Ophthalmology - November 5, 2009 Category: Opthalmology Authors: Lazzeri D, Lazzeri S, Figus M, Tascini C, Bocci G, Colizzi L, Giannotti G, Lorenzetti F, Gandini D, Danesi R, Menichetti F, Del Tacca M, Nardi M, Pantaloni M Tags: Br J Ophthalmol Source Type: journals

Epidemiology and Outcomes of Hospitalizations with Complicated Skin and Skin‐Structure Infections: Implications of Healthcare‐Associated Infection Risk Factors • Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Healthcare‐associated cSSSIs are common and are likely to be caused by gram‐negative organisms. Mixed infections carry a >2‐fold greater risk of inappropriate treatment. Healthcare‐associated cSSSIs are associated with increased mortality and prolonged length of hospital stay, compared with community‐acquired cSSSIs. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - November 4, 2009 Category: Epidemiology Tags: article Original Article Source Type: journals

Risk Factors for Mortality in Patients with Nosocomial Stenotrophomonas maltophilia Pneumonia • Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. S. maltophilia pneumonia is associated with a high mortality rate and is commonly associated with concomitant polymicrobial colonization or infection. Underlying comorbidities and inadequate initial empirical antibiotic therapy substantially account for increased mortality rates. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - November 4, 2009 Category: Epidemiology Tags: article ORIGINAL ARTICLE Source Type: journals

Pouchitis disease activity index (PDAI) does not predict patients with symptoms of pouchitis who will respond to antibioticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Antibiotic treatment was effective in a considerable number of ulcerative colitis patients whose PDAI score was less than 7 after IPAA. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00595-009-3988-7Authors Mohei Kohyama, Hiroshima General Hospital Department of Surgery 1-3-3 Jigozen, Hatsukaichi Hiroshima 738-8503 JapanYoshio Takesue, Hyogo College of Medicine Department of Infection Control and Prevention Nishinomiya, Hyogo JapanHiroki Ohge, Hiroshima University Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences Hiroshima ...
Source: Surgery Today - November 2, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Primary care management of otitis media among Australian children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acute otitis media (AOM) is diagnosed on the basis of acute onset of pain and fever; a red, bulging tympanic membrane; and middle ear effusion. AOM is managed with analgesia (paracetamol or non-steroidal anti-inflammatory drugs). Antibiotic therapy is minimally effective for most patients; it is most effective for children < 2 years with bilateral otitis media and for children with discharging ears. National guidelines recommend antibiotic therapy for Indigenous children with AOM. Evidence for corticosteroids, topical analgesia and xylitol are scant. Otitis media with effusion (OME) is diagnosed as the presence of m...
Source: Med J Aust - November 2, 2009 Category: Journals (General) Authors: Gunasekera H, O'Connor TE, Vijayasekaran S, Del Mar CB Tags: Med J Aust Source Type: journals

Otitis media: viruses, bacteria, biofilms and vaccines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Otitis media typically presents as either acute otitis media (AOM), with symptoms including fever, otalgia, otorrhoea or irritability and short duration; or as otitis media with effusion (OME), which is often asymptomatic and characterised by accumulation of fluid in the middle ear. Diagnostic certainty of otitis media is challenging, given the young age of patients and variability of symptoms. Otitis media predominantly occurs as coincident to viral upper respiratory tract infections and/or bacterial infections. Common viruses that cause upper respiratory tract infection are frequently associated with AOM and new-onse...
Source: Med J Aust - November 2, 2009 Category: Journals (General) Authors: Massa HM, Cripps AW, Lehmann D Tags: Med J Aust Source Type: journals

Antimicrobial Resistance in Haemophilus influenzae Respiratory Tract Isolates in Korea: Results of the Nationwide Acute Respiratory Infections Surveillance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antimicrobial susceptibility patterns and beta-lactam resistance mechanisms of 544 H. influenzae isolates through the nationwide Acute Respiratory Infections Surveillance (ARIS) network in Korea during 2005 and 2006 were determined. Resistance to ampicillin was 58.5%, followed by cefuroxime (23.3%), clarithromycin (18.7%), cefaclor (17.0%), amoxicillin/clavulanate (10.4%), and chloramphenicol (8.1%). Levofloxacin and cefotaxime were the most active agents tested in this study. beta-lactamase production (52.4%) was the main mechanism of ampicillin resistance, with the rate (96.1%) of TEM-1 type beta-lactamase. According...
Source: Antimicrobial Agents and Chemotherapy - November 2, 2009 Category: Microbiology Authors: Bae S, Lee J, Lee J, Kim E, Lee S, Yu J, Kang Y Tags: Antimicrob Agents Chemother Source Type: journals

Association between Plaque-Type Psoriasis and Perianal Streptococcal Cellulitis and Review of the Literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a four-year-old boy with perianal streptococcal dermatitis who was brought to our clinic with plaque type psoriasis. PMID: 19877754 [PubMed - in process] (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - November 1, 2009 Category: Middle East Health Authors: Rasi A, Pour-Heidari N Tags: Arch Iran Med Source Type: journals

Office Endometrial Ablation with Local Anesthesia Using the HydroThermAblator System: Comparison of Outcomes in Patients with Submucous Myomas with Those with Normal Cavities in 246 Cases Performed Over 5½ YearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hydrothermablation performed in the medical office using local anesthesia seems to be a safe, effective, and cost-saving procedure for treatment of abnormal uterine bleeding in women with both normal and myomatous uteri. Although the success rate in patients with normal cavities was higher than that achieved in patients with submucous myomas, hysterectomy because of abnormal bleeding related to myomas was avoided in 88.4% of the group with myomas. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - November 1, 2009 Category: OBGYN Authors: Mark H. Glasser, Peter K. Heinlein, Yun-Yi Hung Tags: Original Articles Source Type: journals

Scar Abscess Six Years after Cesarean Section: Laparoscopic and Hysteroscopic ManagementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the case of a patient who presented an abscess in the cesarean section scar tissue 6 years after the surgery. The myometrium covering the abscess was almost absent. This lesion was first managed with antibiotic therapy and ultrasound-guided aspiration. After failure of the initial therapy, this situation was managed by hysteroscopic fulguration of the capsule under laparoscopic control. For patients with abscesses spreading into the uterine cavity, endoscopic management is a feasible and safe intervention that may be offered to the patient after a correct evaluation. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - November 1, 2009 Category: OBGYN Authors: César Diaz-Garcia, Juan Gilabert Estellés, Alicia Marzál Escrivá, Juan José Hidalgo Mora, Rafael Romaguera Torregrosa, Javier Monleón Sancho Tags: Case Reports Source Type: journals

[A case of acute and necrotizing cutaneous Mycobacterium marinum infection in a patient treated with infliximab for Crohn's disease.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of severe cutaneous Mycobacterium marinum infection in a patient treated with infliximab and we discuss therapeutic options. PATIENTS AND METHODS: A man treated with infliximab for Crohn's disease developed a severe cutaneous infection with M. marinum. Despite withdrawal of infliximab and the introduction of triple antibiotic therapy, the patient's lesions worsened and surgical treatment was required. DISCUSSION: The worsening experienced by our patient 1 week after the beginning of the treatment is comparable with the immune reconstitution syndrome occasionally observed in tuberculosis in immunocompromise...
Source: Annales de Dermatologie et de Cenereologie - November 1, 2009 Category: Dermatology Authors: Guyot A, Begon E, Abramowitz L, Landry J, Marinho E, Descamps V, Crickx B Tags: Ann Dermatol Venereol Source Type: journals

Suture-related complications after cataract surgery: A patient safety issueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The recent case series by Lee et al. highlights the potential morbidity that may result from a retained corneal suture placed during routine cataract surgery via a clear corneal incision. We managed a similar case at our institution. Cataract extraction and intraocular lens implantation via a superotemporal corneal incision had been performed in the right eye of a 67-year-old man 18 months previously at another hospital. The clinical appearance was suggestive of small-incision cataract surgery. On presentation to us, a retained 10-0 nylon corneal suture was found at 10 o'clock, associated with a 1.5 mm stromal abscess and...
Source: Journal of Cataract and Refractive Surgery - October 31, 2009 Category: Opthalmology Authors: Roxane J. Hillier, Rajitha R. Ajit, Simon P. Kelly Tags: Letters Source Type: journals

Role of antibiotic lock therapy for the treatment of catheter-related bloodstream infections.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Catheter-related bloodstream infections are often difficult to treat because they are caused by organisms that embed themselves in a biofilm layer on the catheter surface, resulting in an increased resistance to antimicrobial agents. Systemic antibiotics are usually administered but, although generally effective in eliminating circulating bacteria, they frequently fail to sterilize the line, leaving the patient at a continuing risk of complications or recurrence. A successful approach to managing these infections requires making an appropriate decision regarding whether the catheter should be removed or retained using ...
Source: The International Journal of Artificial Organs - October 31, 2009 Category: Transplant Surgery Authors: Del Pozo JL Tags: Int J Artif Organs Source Type: journals

Inappropriate Initial Antibiotic Treatment May Extend Stays for Patients with Healthcare-Associated Skin InfectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Philadelphia, PA – October 30, 2009 – Patients who acquire skin and soft tissue infections (SSTIs) in a hospital or other healthcare setting may be more likely to receive inappropriate antibiotic therapy at the beginning of... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - October 30, 2009 Category: Pharmaceuticals Source Type: clinical trials

[Childhood laterocervical abscess fistulized in the pharynx: A case study.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a case of an exceptional direct communication between a retropharyngeal abscess and a cervical adenophlegmon, observed in a 25-month-old child. Treatment comprised double antibiotic therapy and retropharyngeal drainage, which led to the subsidence of the laterocervical abscess. The progression was uncomplicated. PMID: 19880296 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - October 30, 2009 Category: Pediatrics Authors: Ondzotto G, Fouemina T, Oko A, Akolbout D, Itiere F Tags: Arch Pediatr Source Type: journals

Mitochondrial pharmacogenomics: barcode for antibiotic therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ribosomal RNA (rRNA)-targeting drugs inhibit protein synthesis and represent effective antibiotics for the treatment of infectious diseases. Given the bacterial origins of mitochondria, the molecular and structural components of the protein expression system are much alike. Moreover, the mutational rate of mitochondrial rRNAs is higher than that of nuclear rRNAs, and some of these mutations might simulate the microorganism's rRNA structure. Consequently, individuals become more susceptible to antibiotics, the mitochondrial function is affected and toxic effects appear. Systems are available to analyze the interaction b...
Source: Drug Discovery Today - October 30, 2009 Category: Drugs & Pharmacology Authors: Pacheu-Grau D, Gómez-Durán A, López-Pérez MJ, Montoya J, Ruiz-Pesini E Tags: Drug Discov Today Source Type: journals

Actinomyces in Chronic Granulomatous Disease: An Emerging and Unanticipated PathogenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Actinomycosis should be vigorously sought and promptly treated in patients with CGD presenting with uncommon and prolonged clinical signs of infection. Actinomycosis is a catalase‐negative infection important to consider in CGD. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - October 29, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

Impact of stroke on therapeutic decision making in infective endocarditisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The diagnosis of infective endocarditis (IE) must be made as soon as possible to initiate antimicrobial therapy and identify patients at high risk for complications who may be best managed by early surgery. Cerebral complications make the timing of cardiac surgery difficult. The safety of cardiopulmonary bypass (CPB) surgery in stroke patients remains controversial. Stroke complicates the outcome of left-sided IE in 20–40% of cases and is associated with poor outcome. The risk of stroke in IE falls rapidly after the initiation of effective antimicrobial therapy. The risk of embolization is highest...
Source: Journal of Neurology - October 29, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals

Commentary: Adjustment of dosing of antimicrobial agents for bodyweight in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Lancet Area: News The Lancet has featured a commentary discussing body size characteristics of patients for the prescribing of antimicrobial agents in the general population. The authors are of the opinion that the "one-size-fits-all strategy for prescribing antimicrobial agents to adults is outdated in the era of increasing antimicrobial drug resistance." They conclude that relevant studies are required to provide guidance to clinicians on the common clinical question of how to achieve optimum eff ectiveness and safety of antimicrobial therapy for patients whose physical characteristics deviate from av...
Source: NeLM - News - October 28, 2009 Category: Drugs & Pharmacology Source Type: organizations

Antibiotic Prophylaxis May Halt UTI Recurrence in ChildrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In children with recurrent urinary tract infections, low-dose, continuous oral antibiotic therapy may help prevent future recurrences, according to an Australian study in the Oct. 29 issue of the New England Journal of Medicine. (Source: Modern Medicine)
Source: Modern Medicine - October 28, 2009 Category: Journals (General) Source Type: info

Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in ChildrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study from four Australian centers examined whether low-dose, continuous oral antibiotic therapy would prevent urinary tract infection in children (under the age of 18 years) who had already had one or more microbiologically proven urinary tract infections. Long-term, low-dose trimethoprim-sulfamethoxazole was associated with a modest decrease in the number of urinary tract infections in predisposed children. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - October 28, 2009 Category: Internal Medicine Authors: Craig, J. C., Simpson, J. M., Williams, G. J., Lowe, A., Reynolds, G. J., McTaggart, S. J., Hodson, E. M., Carapetis, J. R., Cranswick, N. E., Smith, G., Irwig, L. M., Caldwell, P. H.Y., Hamilton, S., Roy, L. P., the Prevention of Recurrent Urinary Tract Tags: ORIGINAL ARTICLES Source Type: journals

Clinical evaluation of NucliSENS magnetic extraction and NucliSENS analytical specific reagents for the real-time detection of respiratory syncytial virus (RSV) in paediatric respiratory specimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: NRSVA is sensitive and specific for RSV detection in respiratory samples. The R-IC monitored the test process, including NA extraction, target amplification and detection. The rapid detection of respiratory pathogens can foster appropriate patient management. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Manji, R, Lotlikar, M, Zhang, F, Ginocchio, C C Tags: TB and other respiratory infections Original articles Source Type: journals

Clinical Practice: Topical Antimicrobial Therapy for Treating Chronic WoundsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Infectious Diseases, Volume 49, Issue 10, Page 1541-1549, 15 November 2009. Various agents have been applied topically to treat infected wounds for millennia, but their proper role remains unclear. Topical therapy affords many potential advantages but also has disadvantages. Opinions differ on which clinical signs define wound infection and on whether quantitative microbiological studies are useful. Clinically infected wounds usually require systemic antibiotic therapy, whereas clinically uninfected wounds that are healing as expected do not require antimicrobials. There is controversy over how to treat poor...
Source: Clinical Infectious Diseases Latest Issue - October 27, 2009 Category: Infectious Diseases Tags: article CLINICAL PRACTICE Source Type: journals

The influence of tigecycline on the expression of virulence factors in biofilm-associated cells of methicillin resistant Staphylococcus aureus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests that tigecycline may reduce the expression of important virulence factors in S. aureus and supports further investigation to determine whether it could be a useful adjunct to therapy for the treatment of biofilm-mediated infections. PMID: 19858261 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - October 26, 2009 Category: Microbiology Authors: Smith K, Gould KA, Ramage G, Gemmell CG, Hinds J, Lang S Tags: Antimicrob Agents Chemother Source Type: journals

Empiric antibiotic therapy in acute uncomplicated urinary tract infections and fluoroquinolone resistance: a prospective observational studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The aims of this study were to determine the antimicrobial susceptibility patterns of urinary isolates from community acquired acute uncomplicated urinary tract infections (uUTI) and to evaluate which antibiotics were empirically prescribed in the outpatient management of uUTI. Methods: Among the patients which were admitted to outpatient clinics of Ankara University Medical Faculty, Ibni-Sina Hospital during 2005-2006, a total of 429 women between the age of 18 and 65 years old who were clinically diagnosed with uUTI and to whom prescribed empirical antibiotics were enrolled in this prospective observational s...
Source: BioMed Central - October 23, 2009 Category: Journals (General) Authors: Cenk AypakAdalet AltunsoyNursen Duzgun Source Type: journals

Risk Factors for Mortality in Patients with Nosocomial Stenotrophomonas maltophilia PneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. S. maltophilia pneumonia is associated with a high mortality rate and is commonly associated with concomitant polymicrobial colonization or infection. Underlying comorbidities and inadequate initial empirical antibiotic therapy substantially account for increased mortality rates. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - October 23, 2009 Category: Epidemiology Tags: article ORIGINAL ARTICLE Source Type: journals

Management of acne vulgaris: an evidence-based updateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review summarizes clinically important findings from 3 systematic reviews, 1 updated guideline and a selection from the 62 randomized controlled trials (RCTs) published between February 2007 and January 2009 on the topic of acne vulgaris. Low glycaemic-load diets might reduce acne severity but this remains unproven. Written patient information leaflets have not been surpassed by other communication methods. New combination topical treatments have not shown convincing advantages over current combination products such as clindamycin/benzoyl peroxide. Topical dapsone is superior to placebo but has yet to be compared with...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: J. R. Ingram, D. J. C. Grindlay, H. C. Williams Source Type: journals

Epidemiology and Outcomes of Hospitalizations with Complicated Skin and Skin‐Structure Infections: Implications of Healthcare‐Associated Infection Risk FactorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Healthcare‐associated cSSSIs are common and are likely to be caused by gram‐negative organisms. Mixed infections carry a >2‐fold greater risk of inappropriate treatment. Healthcare‐associated cSSSIs are associated with increased mortality and prolonged length of hospital stay, compared with community‐acquired cSSSIs. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - October 22, 2009 Category: Epidemiology Tags: article Original Article Source Type: journals