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462 records returned

Asymptomatic diffuse "encephalitic" cerebral toxoplasmosis in a patient with chronic lymphocytic leukemia: case report and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 70 year old male with stage IV chronic lymphocytic leukemia complicated by aplastic anemia. Neurological examination and imaging revealed no significant abnormalities. At autopsy, the brain revealed multifocal cysts and free tachyzoites of Toxoplasma gondii with diffuse microglial nodules and no necrosis. To the best of our knowledge, this case represents the first report of the "encephalitic" form of toxoplasmosis in a non-AIDS patient. PMID: 19918334 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Abedalthagafi M, Rushing EJ, Garvin D, Cheson B, Ozdemirli M Tags: Int J Clin Exp Pathol Source Type: journals

Spontaneous liver rupture in a patient with peliosis hepatis: a case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Peliosis hepatis is a rare pathological entity and may cause fatal hepatic hemorrhage and liver failure. Here, we present a young male patient with aplastic anemia, who had received long-term treatment with oxymetholone. The patient suffered from sudden onset of intra-abdominal hemorrhage with profuse hemoperitoneum. The patient was treated successfully with a right hemihepatectomy and is in good health after 13 postoperative months. We suggest that peliosis hepatis be considered in patients with hepatic parenchymal hematoma, especially in patients under prolonged synthetic anabolic steroid medication. The possibility ...
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Choi SK, Jin JS, Cho SG, Choi SJ, Kim CS, Choe YM, Lee KY Tags: World J Gastroenterol Source Type: journals

Deferasirox (Exjade) for the treatment of iron overload.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deferasirox is a once-daily oral iron chelator with established dose-dependent efficacy in both adult and pediatric patients with transfusional iron overload. The clinical development program has demonstrated the efficacy of deferasirox for up to 4.5 years of treatment in patients with various underlying anemias, including beta-thalassemia, myelodysplastic syndromes, sickle cell disease, aplastic anemia, and other rare anemias. In addition to reducing key indicators of total body iron levels (serum ferritin, liver iron concentration, and toxic labile plasma iron), deferasirox has also demonstrated the ability to remove...
Source: Acta Haematologica - November 13, 2009 Category: Hematology Authors: Cappellini MD, Taher A Tags: Acta Haematol Source Type: journals

A Pharmacovigilance Program From Laboratory Signals for the Detection and Reporting of Serious Adverse Drug Reactions in Hospitalized Patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the implementation of a prospective pharmacovigilance program based on automatic laboratory signals (ALSs) at a hospital. We also report the general findings after the first year of operation of the program, which involved ALSs that indicate various SADRs: agranulocytosis, aplastic anemia, liver injury, thrombocytopenia, hyponatremia, and rhabdomyolysis. The number of hospitalizations during the year was 54,525, and 1,732 patients experienced at least one ALS. The review of electronic medical records (EMRs) showed that no alternative cause (i.e., no non-SADR explanation) for the ALS was identified in 520 (30%) o...
Source: Clinical Pharmacology and Therapeutics - November 4, 2009 Category: Drugs & Pharmacology Authors: Ramirez E, Carcas AJ, Borobia AM, Lei SH, Piñana E, Fudio S, Frias J Tags: Clin Pharmacol Ther Source Type: journals

Comparison on In Vitro Characterization of Fucospheres and Chitosan Microspheres Encapsulated Plasmid DNA (pGM-CSF): Formulation Design and Release Characteristics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the characterizations of the microspheres can be modulated by changing the formulation variables, and it can be concluded that fucospheres might be a potential carrier system for the controlled delivery of GM-CSF encoding plasmid DNA. PMID: 19859814 [PubMed - as supplied by publisher] (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - October 27, 2009 Category: Drugs & Pharmacology Authors: Demir Sezer A, Akbuğa J Tags: AAPS PharmSciTech Source Type: journals

Temozolomide: Aplastic anaemia in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 26, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

The transplant iron score as a predictor of stem cell transplant survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent studies have suggested that the presence of iron overload prior to stem cell transplantation is associated with decreased survival. Within these studies, the criteria used to define iron overload have varied considerably. Given the lack of consensus regarding the definition of iron overload in the transplant setting, we sought to methodically examine iron status among transplant patients. We studied 78 consecutive patients at risk for transfusion-related iron overload (diagnoses included AML, ALL, MDS, and aplastic anemia) who received either autologous or allogeneic stem cell transplant. Multiple measures of iron s...
Source: Journal of Hematology and Oncology - October 23, 2009 Category: Hematology Authors: Jonathan StoreyRebecca ConnorZachary LewisDavid HurdGregory PomperYi KeungManisha GroverJames LovatoSuzy TortiFrank TortiIstvan Molnar Source Type: journals

Chicken anemia virus infection in broiler chickens in Shahrekord, Iran: serological, hematological, and histopathological findingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Chicken infectious anemia caused by a single-strand DNA circovirus is a disease in young chickens that is characterized by aplastic anemia, generalized lymphoid atrophy, and immunosuppression. In the present study, the presence of chicken anemia virus (CAV) infection and the hematologic and histopathologic changes in CAV seropositive broiler chickens in Shahrekord region, center of Iran, were investigated. Blood and lymphoid tissue samples were obtained from 271, 2–6-week-old chicks of 23 commercial broiler chicken flocks. Measurement of CAV antibody titers by enzyme-linked immunosorbent assay (EL...
Source: Comparative Clinical Pathology - October 14, 2009 Category: Pathology Tags: Comparative Clinical Pathology Source Type: journals

Hairy cell leukemia responsive to anti-thymocyte globulin used as immunosuppressive therapy for aplastic anemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hairy cell leukemia (HCL) is occasionally misdiagnosed as aplastic anemia when only a few leukemic cells are present in the circulation. Here, we describe a patient with HCL who initially presented with pancytopenia and received a diagnosis of aplastic anemia. The patient was treated with immunosuppressive therapy including cyclosporine A and anti-thymocyte globulin (ATG). No blood cell transfusion was required for approximately 3 years after ATG therapy. She was referred to our hospital because of an abdominal mass and requiring periodic blood transfusions. A bone marrow biopsy at this time revealed proliferation of l...
Source: International Journal of Hematology - October 13, 2009 Category: Hematology Authors: Fujiwara S, Miyake H, Nosaka K, Yoshida M, Ishihara S, Horikawa K, Yonemura Y, Iyama K, Mitsuya H, Asou N Tags: Int J Hematol Source Type: journals

High-dose cyclophosphamide treatment for refractory severe aplastic anemia in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To determine if high-dose cyclophosphamide is an effective therapy for children with refractory severe aplastic anemia (SAA).SAA is an illness characterized by the depletion of hematopoietic precursors associated with life-threatening complications. Hematopoietic stem cell transplant (HSCT) is the treatment of choice if a human leukocyte antigen (HLA)-related donor is available. Immunosuppression with anti-thymocyte globulin (ATG) and cyclosporine A (CSA) is an option for patients who are not HSCT candidates. Unrelated donor HSCT has been used with limited success. High-dose cyclophosphamide has been used successfully in t...
Source: Pediatric Blood and Cancer - October 12, 2009 Category: Cancer & Oncology Authors: Anthony N. Audino, Julie Blatt, Benjamin Carcamo, Victoria Castaneda, Patricia Dinndorf, Winfred C. Wang, James A. Whitlock, Jeffrey D. Hord Source Type: journals

Varicella zoster virus vaccine live: Aplastic anaemia in an infant: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 12, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Implications of CD34+ cell dose on clinical and haematological outcome of allo-SCT for acquired aplastic anaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Implications of CD34+ cell dose on clinical and haematological outcome of allo-SCT for acquired aplastic anaemia Bone Marrow Transplantation advance online publication, October 12, 2009. doi:10.1038/bmt.2009.267 Authors: M S Islam, P Anoop, P Datta-Nemdharry, D Sage, E C Gordon-Smith, D Turner, S Wiltshire, L O'Regan & J C W Marsh (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - October 11, 2009 Category: Hematology Authors: M S IslamP AnoopP Datta-NemdharryD SageE C Gordon-SmithD TurnerS WiltshireL O'ReganJ C W Marsh Source Type: journals

Association of HLA class II alleles with response to immunosuppressive therapy in Korean aplastic anemia patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HLA-DR15 (DR2) is overrepresented in aplastic anemia (AA) patients, and its presence is associated with a better response to cyclosporine-based immunosuppressive therapy (IST). However, little is known about other HLA alleles affecting therapy response. We investigated 37 Korean patients with severe AA for the association of HLA class II alleles with response to IST: cyclosporine A combined with anti-thymocyte globulin or anti-lymphocyte globulin. Molecular or serologic typing of HLA-DR and HLA-DQ alleles was performed. In responders (13/37, 35.1%), the frequency of HLA-DR15 was increased (69.2% vs 8.3%, p = 0.0002) an...
Source: Human Immunology - October 7, 2009 Category: Allergy & Immunology Authors: Song EY, Kang HJ, Shin HY, Ahn HS, Kim I, Yoon SS, Park S, Kim BK, Park MH Tags: Hum Immunol Source Type: journals

Nobel prize for medicine awarded for work on cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discovery of how chromosomes are protected earns US trio top prize in medicine. Ian Sample reportsThe discovery of a biological gatekeeper that prevents genetic code from fraying with age has won a trio of American scientists this year's Nobel prize for medicine.The prestigious award – and the 10m Swedish kronor (£818,000) prize money – is shared by Elizabeth Blackburn, 60, Carol Greider, 48, and Jack Szostak, 56. It is the first time the prize has honoured two women at once.The researchers identified one of the most critical and intriguing processes in living organisms, one that has deep implications for understandin...
Source: Guardian Unlimited Science - October 5, 2009 Category: Science Authors: Ian Sample Tags: Medical research Science United States World news guardian.co.uk Source Type: news

Advances in the treatment of aplastic anemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Impressive response rates and the good tolerability have allowed imatinib to become the gold standard frontline therapy for all CML patients in the early chronic phase. Optimal outcomes are attained with more than two thirds of the CML cases treated with standard dose imatinib (400 mg daily). Criteria to establish failure and suboptimal responses to imatinib have been defined. Treatment guidelines have also suggested imatinib dose escalation based on clinical assessments of disease response. However, despite all the effort to optimize therapy with imatinib, cases of real resistance exist. For imatinib resistant and intoler...
Source: Revista Brasileira de Hematologia e Hemoterapia - October 2, 2009 Category: Hematology Source Type: journals

Aplastic Anemia & MDS International Foundation Research Grant OpportunitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aplastic Anemia & MDS International Foundation Research Grant Opportunities AA&MDSIF is pleased to help researchers advance the understanding and treatment of aplastic anemia, myelodysplastic syndromes (MDS) and paroxysmal nocturnal hemoglobinuria (PNH). For more than twenty years, the AA&MDSIF has provided financial support to research that leads to new insights into the causes of bone marrow failure and the development of new therapeutic approaches.Each year the AA&MDSIF invites researchers to apply for two-year grants of $30,000 per year to test new ideas and to explore other research leads. The applicat...
Source: ScanGrants feed - October 1, 2009 Category: Research Authors: aplastic anemia & MDS International Foundation Source Type: funding

Spectrum of anemia associated with chronic liver disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anemia of diverse etiology is a common complication of chronic liver diseases. The causes of anemia include acute or chronic gastrointestinal hemorrhage, and hypersplenism secondary to portal hypertension. Severe hepatocellular disease predisposes to hemorrhage because of impaired blood coagulation caused by deficiency of blood coagulation factors synthesized by hepatocytes, and/or thrombocytopenia. Aplastic anemia, which is characterized by pancytopenia and hypocellular bone marrow, may follow the development of hepatitis. Its presentation includes progressive anemia and hemorrhagic manifestations. Hematological compl...
Source: World Journal of Gastroenterology : WJG - October 1, 2009 Category: Gastroenterology Authors: Gonzalez-Casas R, Jones EA, Moreno-Otero R Tags: World J Gastroenterol Source Type: journals

Systematic review - hepatitis-associated aplastic anaemia - a syndrome associated with abnormal immunological functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Published September 2009Bottom-line conclusion: Hepatitis-associated bone marrow aplasia is mediated by immunological mechanisms. Treatment options include hematopoietic cell transplantation and immunosuppressive therapy. (Source: Gastroenterology and Liver Diseases Specialist Library - Liver)
Source: Gastroenterology and Liver Diseases Specialist Library - Liver - October 1, 2009 Category: Gastroenterology Source Type: organizations

Thoracoscopic extended thymothymectomy for myasthenia gravis with aplastic anemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is very rare for both myasthenia gravis and aplastic anemia to be complicated with a thymoma. A 74-year-old female was diagnosed to have aplastic anemia with pancytopenia and systemic myasthenia gravis with severe restrictive respiratory dysfunction. Chest CT showed a 5-cm diameter thymoma. After platelets and packed red blood cells were transfused before surgery, an extended thymothymectomy was performed with a bilateral thoracoscopic approach. The thymoma was noninvasive, stage I, and was classified as B1 according to the World Health Organization classification. After the operation, the patient was managed on art...
Source: Annals of Thoracic and Cardiovascular Surgery - October 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Nakamura H, Miwa K, Adachi Y, Fujioka S, Haruki T, Taniguchi Y Tags: Ann Thorac Cardiovasc Surg Source Type: journals

Transfusion related acute lung injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of 10-year-old male child with aplastic anemia, platelet count of 7800/l, B positive blood group who developed fever (39.2C), difficulty in breathing and cyanosis within 2 hrs after transfusion of a random platelet concentrate. Despite the best resuscitative efforts, the child died within next 24 hrs. The present case highlights the fact that TRALI should be kept as a differential diagnosis in all patients developing acute respiratory discomfort within 6 hrs of transfusion. Without a 'gold standard' the diagnosis of TRALI relies on a high index of suspicion and on excluding other types of transfusion rea...
Source: Indian Journal of Pathology and Microbiology - September 30, 2009 Category: Pathology Authors: Sharma RR, Bhattacharya P, Thakral B, Saluja K, Marwaha N Tags: Indian J Pathol Microbiol Source Type: journals

Downregulation of GATA-2 and overexpression of adipogenic gene-PPARγ in mesenchymal stem cells from patients with aplastic anemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aplastic anemia (AA) is characterized by a reduced number of hematopoietic stem cells and fatty replacement in the bone marrow. Transcriptional factor GATA-2 plays several important roles in both hematopoiesis and adipogenesis. Decreased levels of GATA-2 compromise the proliferation and survival of hematopoietic stem cells. GATA-2 suppresses adipocyte differentiation through direct inhibition of adipogenic factors, including peroxisome proliferator-activated receptor−γ (PPARγ). Previous studies have shown that expression of GATA-2 is decreased in marrow CD34-positive cells in AA. To elucidate the mechanisms of fatty ma...
Source: Experimental Hematology - September 23, 2009 Category: Hematology Authors: Yinyan Xu, Yoshiyuki Takahashi, Yue Wang, Asahito Hama, Nobuhiro Nishio, Hideki Muramatsu, Makito Tanaka, Nao Yoshida, Itzel Bustos Villalobos, Hiroshi Yagasaki, Seiji Kojima Tags: General Hematopoiesis Source Type: journals

Ticlopidine: Aplastic anaemia: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 21, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Use of a FLAER-based WBC assay in the primary screening of PNH clones.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) with flow cytometry traditionally involves the analysis of CD55 and CD59 on RBCs and neutrophils. However, the ability to accurately detect PNH RBCs is compromised by prior hemolysis and/or transfused RBCs. Patients with aplastic anemia (AA) and myelodysplastic syndrome (MDS) can also produce PNH clones. We recently described a multiparameter fluorescent aerolysin (FLAER)-based flow assay using CD45, CD33, and CD14 that accurately identified PNH monocyte and neutrophil clones in PNH, AA, and MDS. Here, we compared the efficiency of this WBC assay with a CD59-based ...
Source: American Journal of Clinical Pathology - September 21, 2009 Category: Pathology Authors: Sutherland DR, Kuek N, Azcona-Olivera J, Anderson T, Acton E, Barth D, Keeney M Tags: Am J Clin Pathol Source Type: journals

A Rare Case of Aplastic Anemia Caused by Temozolomide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 65-year-old female with glioblastoma multiforme (GBM) who developed aplastic anemia from temozolomide is reported. The patient presented with rapidly developing slurred speech, apathy, memory difficulties, an ataxic gait, and right-sided weakness. She was found to have GBM. She received standard external beam radiotherapy concomitant with temozolomide, followed by adjuvant temozolomide. On day 14 of adjuvant treatment, she presented with profound fatigue and spontaneous bruising and was noted to be severely pancytopenic. After an extensive workup, she was found to have aplastic anemia on bone marrow biopsy. This case rep...
Source: Southern Medical Journal - September 15, 2009 Category: Journals (General) Tags: Abstract HTML PDF (511 K) Source Type: journals

Tacrolimus/Methotrexate versus Cyclosporine/Methotrexate as Graft-versus-Host Disease Prophylaxis in Patients with Severe Aplastic Anemia Who Received Bone Marrow Transplantation from Unrelated Donors: Results of Matched Pair AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tacrolimus (FK) and cyclosporine (CsA) have been shown to be effective in the prophylaxis of graft-versus-host disease (GVHD). However, no comparative studies have yet been conducted to examine the efficacy of FK/methotrexate (MTX) and CsA/MTX in patients with severe aplastic anemia (SAA) given unrelated donor bone marrow transplantation (U-BMT). We used matched-pair analysis to compare FK/MTX with CsA/MTX in patients with SAA who received U-BMT through the Japan Marrow Donor Program. Forty-seven pairs could be matched exactly for recipient age and conditioning regimens. Forty-five patients achieved engraftment in the FK g...
Source: Biology of Blood and Marrow Transplantation - September 14, 2009 Category: Hematology Authors: Hiroshi Yagasaki, Seiji Kojima, Hiromasa Yabe, Koji Kato, Hisato Kigasawa, Hisashi Sakamaki, Masahiro Tsuchida, Shunichi Kato, Takakaza Kawase, Hideki Muramatsu, Yasuo Morishima, Yoshihisa Kodera Tags: Clinical Research Source Type: journals

Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Androgens have been used in the treatment of bone marrow failure syndromes without a clear understanding of their mechanism of action. Blood counts of patients with dyskeratosis congenita or aplastic anemia with mutations in telomerase genes can improve with androgen therapy. Here we observed that exposure in vitro of normal peripheral blood lymphocytes and human bone marrow–derived CD34+ cells to androgens increased telomerase activity, coincident with higher TERT mRNA levels. Cells from patients who were heterozygous for telomerase mutations had low baseline telomerase activity, which was restored to normal levels ...
Source: Blood - September 9, 2009 Category: Hematology Authors: Calado, R. T., Yewdell, W. T., Wilkerson, K. L., Regal, J. A., Kajigaya, S., Stratakis, C. A., Young, N. S. Tags: Hematopoiesis and Stem Cells Source Type: journals

Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When successful, human leukocyte antigen (HLA)–matched bone marrow transplantation with reduced-intensity conditioning is a cure for several nonmalignant hematologic disorders that require chronic transfusion, such as sickle cell disease and aplastic anemia. However, there are unusually high bone marrow transplant (BMT) rejection rates in these patients. Rejection correlates with the number of transfusions before bone marrow transplantation, and it has been hypothesized that preimmunization to antigens on transfused blood may prime BMT rejection. Using a novel mouse model of red blood cell (RBC) transfusion and major...
Source: Blood - September 9, 2009 Category: Hematology Authors: Desmarets, M., Cadwell, C. M., Peterson, K. R., Neades, R., Zimring, J. C. Tags: Immunobiology, Transfusion Medicine, Transplantation Source Type: journals

Improved outcome of patients older than 30 years receiving HLA-identical sibling hematopoietic stem cell transplantation for severe acquired aplastic anemia using fludarabine-based conditioning: a comparison with conventional conditioning regimen.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Older age is a limitation for HLA-identical sibling hematopoietic stem cell transplantation (HSCT) as first-line therapy for severe acquired idiopathic aplastic anemia (SAA). Fludarabine (Flu)-based conditioning might improve outcome in older patients. We analyzed retrospectively 30 patients older than 30 years receiving such reduced-intensity conditioning HSCT according to recommendations of the European Group for Blood and Marrow Transplantation (EBMT) and compared their outcome to a control group receiving the standard regimen (cyclophosphamide+/-antithymocyte globulin) over the same study period (1998-2007). Patie...
Source: Haematologica - August 31, 2009 Category: Hematology Authors: Maury S, Bacigalupo A, Anderlini P, Aljurf M, Marsh J, Socié G, Oneto R, Passweg JR, Tags: Haematologica Source Type: journals

Incidence and risk factors of aplastic anemia in Latin American countries: the LATIN case-control study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The incidence of aplastic anemia in Latin America countries is low. Although the research study centers had a high coverage of health services, the underreporting of cases of aplastic anemia in selected regions can be discussed. Frequent exposure to benzene-based products increases the risk for aplastic anemia. Few associations with specific drugs were found, and it is likely that some of these were due to chance alone. PMID: 19734415 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - August 31, 2009 Category: Hematology Authors: Maluf E, Hamerschlak N, Cavalcanti AB, Júnior AA, Eluf-Neto J, Falcão RP, Lorand-Metze IG, Goldenberg D, Santana CL, de Oliveira Werneck Rodrigues D, Passos LN, Rosenfeld LG, Pitta M, Loggetto S, Feitosa Ribeiro AA, Velloso ED, Kondo AT, de Mira Tags: Haematologica Source Type: journals

Feasibility and eligibility of retreatment with rabbit anti-T lymphocyte globulin for aplastic anemia previously treated with horse anti-thymocyte globulin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19728019 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 28, 2009 Category: Hematology Authors: Miura K, Hatta Y, Kobayashi S, Iriyama Y, Takei K, Takeuchi J Tags: Int J Hematol Source Type: journals

Subcutaneous alemtuzumab plus cyclosporine for the treatment of aplastic anemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Aplastic anemia (AA) is most frequently due to autoimmune attack on its own stem cells. Alemtuzumab is a monoclonal antibody which recognizes the CD52 antigen on the surface of T and B cells. It has proved useful in autoimmune diseases, lymphoproliferative conditions, and graft versus host disease. Based on its immunosuppressive properties, we treated 14 AA patients with alemtuzumab. Median age was 23 years. Ten milligrams of alemtuzumab were injected subcutaneously each day for five consecutive days. Cyclosporine A was also administered orally at a dose of 2 mg/kg every 12 h for 3&nb...
Source: Annals of Hematology - August 24, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals

Erosion of telomeric single-stranded overhang in patients with aplastic anaemia carrying telomerase complex mutationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Telomeric overhang erosion does not participate in physiological ageing but support a role for eroded telomeric overhangs and abnormal telomere structure in pathological shortening of telomeres, especially caused by loss-of-function telomerase mutations. Disrupted telomere structure caused by short telomeric overhangs may contribute to the mechanisms of abnormal haematopoietic compartment senescence and chromosomal instability in human bone marrow failure. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - August 12, 2009 Category: Journals (General) Authors: R. T. Calado, J. A. Regal, S. Kajigaya, N. S. Young Source Type: journals

Squamous cell carcinoma of base of tongue in a patient with Fanconi's anemia treated with radiation therapy: Case report and review of literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of Fanconi's anemia in a 27-year-old man with carcinoma of the base of tongue (T2N0M0) who was treated with radical radiation therapy to a dose of 70 Gy/35 fractions/51 days. We have also done in vitro radiosensitivity tests.The patient tolerated the radiation treatment well and completed it without any interruptions. In vitro studies did not show any increased radiosensitivity in this patient.Head and neck cancer in a patient with FA requires individualized treatment. The decision about opting for different modalities should be based on a balanced approach with respect to locoregional control and toxiciti...
Source: Head and Neck - August 10, 2009 Category: ENT & OMF Authors: Ashwini Budrukkar, Tanweer Shahid, Vedang Murthy, Tabish Hussain, Rita Mulherkar, Babu Rao Vundinti, Mandar Deshpande, Manju Sengar, Sarbani Ghosh-Laskar, Jai Prakash Agarwal Source Type: journals

Guidelines for the diagnosis and management of aplastic anaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Haematology)
Source: British Journal of Haematology - August 9, 2009 Category: Hematology Authors: Judith C. W. Marsh, Sarah E. Ball, Jamie Cavenagh, Phil Darbyshire, Inderjeet Dokal, Edward C. Gordon-Smith, Jane Keidan, Andrew Laurie, Anna Martin, Jane Mercieca, Sally B. Killick, Rhona Stewart, John A. L. Yin Source Type: journals

Salvage Allogeneic Hematopoietic Cell Transplantation with Fludarabine and Low-Dose Total Body Irradiation after Rejection of First AllograftsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We summarized results in 38 consecutive patients (median age=56 years) with hematologic malignancies (n=35), aplastic anemia (n=2), or renal cell carcinoma (n=1), who underwent salvage hematopoietic cell transplantation (HCT) for allograft rejection. In 14 patients, the original donors were used for salvage HCT, and, in 24 cases, different donors were used. Conditioning for salvage HCT consisted of fludarabine (Flu) and either 3 or 4Gy total body irradiation (TBI). Sustained engraftment was achieved in 33 patients (87%). Grafts were rejected in 5 patients (13%), 4 of whom had myelofibrosis. With a median follow-up of 2 yea...
Source: Biology of Blood and Marrow Transplantation - August 2, 2009 Category: Hematology Authors: Boglarka Gyurkocza, Thai M. Cao, Rainer F. Storb, Thoralf Lange, Wendy Leisenring, Georg N. Franke, Mohamed Sorror, Richard Hoppe, David G. Maloney, Robert S. Negrin, Judith A. Shizuru, Brenda M. Sandmaier Tags: Clinical Research Source Type: journals

Successful salvage unrelated umbilical cord blood transplantation with two units after engraftment failure with single unit in severe aplastic anemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Severe aplastic anemia (SAA) patients without an HLA-matched sibling donor need alternative treatment options. Umbilical cord blood transplantation (UCBT) has become an alternative means for treating various diseases, but it has not been proved to be a satisfactory method to treat SAA. Here, we report the case of a girl who underwent successful two-unit UCBT after engraftment failure with a single unit. Two-unit UCBT is proposed to have better engraftment potential and to offer a better chance of survival, according to some reports. Increased cell dose and graft-versus-graft reaction could contribute to these advantage...
Source: J Korean Med Sci - July 31, 2009 Category: Journals (General) Authors: Lee JW, Kang HJ, Kim EK, Shin HY, Ahn HS Tags: J Korean Med Sci Source Type: journals

[Detection of Putative T cell Clones Using T cell Receptor beta Chain Gene Clonality Assay in Korean Patients with Aplastic Anemia.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Putative pathogenetic T cell clones were detected in most of AA patients in the current study. T cell clonality assay would be useful for investigating the pathophysiology of acquired AA. PMID: 19726886 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine)
Source: The Korean Journal of Laboratory Medicine - July 31, 2009 Category: Laboratory Medicine Authors: Choi HJ, Shin MG, Kim HR, Kim HJ, Kook H, Kee SJ, Kim SH, Shin JH, Suh SP, Ryang DW Tags: Korean J Lab Med Source Type: journals

Understanding aplastic anaemia/bone-marrow failure syndromesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The term ‘aplastic anaemias/bone-marrow failure syndromes’ encompasses a heterogeneous group of disorders, including rare inherited genetic diseases and ‘acquired’ idiopathic aplastic anaemia, all characterized by failure of haematopoiesis. In the majority of these conditions the natural history is progressive, and the clinical spectrum includes non-haematological manifestations and a predisposition to cancer. Recent advances have identified mutations in more than 30 different genes which can be grouped into five functional cellular pathways in inherited bone-marrow failure syndromes. Some of these genes ...
Source: Paediatrics and Child Health - July 31, 2009 Category: Pediatrics Authors: Momin Ahmed, Inderjeet Dokal Tags: Symposium: Haematology Source Type: journals

Origin and fate of blood cells deficient in glycosylphosphatidylinositol-anchored protein among patients with bone marrow failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Peripheral blood from 489 recently diagnosed patients with aplastic anaemia (AA) and 316 with refractory anaemia (RA) of myelodysplastic syndrome was evaluated to characterize CD55[minus]CD59[minus] [paroxysmal nocturnal haemoglobinuria (PNH)]-type blood cells associated with bone marrow (BM) failure. PNH-type cells were detected in 57% and 20% of patients with AA and RA, respectively. The percentages of PNH-type granulocytes ranged from 0·003% to 94·2% and the distribution was log-normal with a median of 0·178%. Serial analyses of 75 patients with PNH-type cells over 5 years revealed that the percentage of PNH-type cel...
Source: British Journal of Haematology - July 27, 2009 Category: Hematology Authors: Chiharu Sugimori, Kanako Mochizuki, Zhirong Qi, Naomi Sugimori, Ken Ishiyama, Yukio Kondo, Hirohito Yamazaki, Akiyoshi Takami, Hirokazu Okumura, Shinji Nakao Source Type: journals

Successful first-line treatment with double umbilical cord blood transplantation in severe aplastic anemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& H S Ahn (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - July 27, 2009 Category: Hematology Authors: H J KangJ W LeeH KimH Y ShinH S Ahn Source Type: journals

Allogeneic hematopoietic stem cell transplantation for acquired aplastic anemia using cyclophosphamide and antithymocyte globulin: a single center experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
n & A Ben Abdeladhim (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - July 26, 2009 Category: Hematology Authors: S LadebA AbdelkefiL TorjmanH Ben NejiA LakhalH KaabiL Ben HamedS EnnigrouS HmidaT Ben OthmanA Ben Abdeladhim Source Type: journals

Anti-moesin antibodies derived from patients with aplastic anemia stimulate monocytic cells to secrete TNF-{alpha} through an ERK1/2-dependent pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antibodies specific to moesin, which are frequently detectable in the serum of patients with aplastic anemia (AA), can induce tumor necrosis factor- (TNF-) secretion from monocytes and a human monocytic leukemia cell line THP-1. We investigated the mechanisms responsible for TNF- secretion from monocytic cells induced by the auto-antibodies that are purified from the sera of AA patients. TNF- induction by anti-moesin antibodies depended on the amount of cell surface moesin expressed by THP-1 cells. F(ab')2 fragments prepared from the anti-moesin antibodies were able to stimulate THP-1 cells to secrete TNF- and this stimula...
Source: International Immunology - July 26, 2009 Category: Allergy & Immunology Authors: Espinoza, J. L., Takamatsu, H., Lu, X., Qi, Z., Nakao, S. Tags: ORIGINAL RESEARCH PAPERS Source Type: journals

Thrombopoietin Agonists for the Treatment of Thrombocytopenia in Liver Disease and Hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article examines the nature of thrombocytopenia, ITP, and TPO. (Source: Clinics in Liver Disease)
Source: Clinics in Liver Disease - July 23, 2009 Category: Gastroenterology Authors: Geoffrey Dusheiko Source Type: journals

Myelodysplastic syndromes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Session 4 of the 2007 Workshop of the Society for Hematopathology/European Association for Haematopathology was devoted to myelodysplastic syndromes (MDSs). Submitted cases highlighted important issues and difficulties in relation to the diagnosis and classification of MDS. Much of the discussion focused on the correlation, or lack of it, between morphologic examination and other diagnostic techniques, cytogenetics in particular. The cases included examples of isolated del(5q) chromosomal abnormality, including the "classical" 5q- syndrome and other myeloid neoplasms. Other cytogenetic abnormalities in MDSs and the rol...
Source: American Journal of Clinical Pathology - July 18, 2009 Category: Pathology Authors: Orazi A, Czader MB Tags: Am J Clin Pathol Source Type: journals

Myocardial infarction caused by Aspergillus embolization in a patient with aplastic anemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Itoh M, Takahashi M, Mori M, Tamekiyo H, Yoshida H, Yago K, Shimada H, Arai K (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - July 15, 2009 Category: Respiratory Medicine Source Type: consumer

Changes of cytokine profile pre and post immunosuppression in acquired aplastic anemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests that IS does not fully clear excess TNF-alpha and IFN-gamma from marrow of patients with good outcome and raises the hypothesis that additional cytokine blockade might be useful in IS for AAA. PMID: 19586939 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - July 6, 2009 Category: Hematology Authors: Dufour C, Ferretti E, Bagnasco F, Burlando O, Lanciotti M, Ramenghi U, Saracco P, Van Lint MT, Longoni D, Torelli GF, Pillon M, Locasciulli A, Misuraca A, La Spina M, Bacigalupo A, Pistoia V, Corcione A, Svahn J, Tags: Haematologica Source Type: journals

NKG2D-mediated immunity underlying paroxysmal nocturnal haemoglobinuria and related bone marrow failure syndromesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is considered that a similar immune mechanism acts in the pathogenesis of bone marrow (BM) failure in paroxysmal nocturnal haemoglobinuria (PNH) and its related disorders, such as aplastic anaemia (AA) and myelodysplastic syndromes (MDS). However, the molecular events in immune-mediated marrow injury have not been elucidated. We recently reported an abnormal expression of stress-inducible NKG2D (natural-killer group 2, member D) ligands, such as ULBP (UL16-binding protein) and MICA/B (major histocompatibility complex class I chain-related molecules A/B), on granulocytes in some PNH patients and the granulocyte killing b...
Source: British Journal of Haematology - July 5, 2009 Category: Hematology Authors: Nobuyoshi Hanaoka, Hideki Nakakuma, Kentaro Horikawa, Shoichi Nagakura, Yasuchika Tsuzuki, Masaya Shimanuki, Kensuke Kojima, Yuji Yonemura, Tatsuya Kawaguchi Source Type: journals

Patterns of infection in patients with aplastic anemia and the emergence of Aspergillus as a major cause of deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Weinberger M, Elattar I, Marshall D, Steinberg SM, Redner RL, Young NS, Pizzo PA (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - July 2, 2009 Category: Respiratory Medicine Source Type: consumer

Bartonellosis as cause of death after red blood cell unit transfusion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors present the case of a young man with aplastic anemia who went into shock and died after several red blood cell unit transfusions. Immunohematological studies did not show any abnormality and blood cultures from patients and blood bags were negative. The ultrastructural findings, allied with current scientific knowledge, permitted the diagnosis of Bartonella sp. infection. In face of this diagnosis, two possibilities should be considered: the first one is that the patient was already infected by the bacteria before the last RBC unit transfusion. The pathogen could be involved in aplastic anemia etiology and ...
Source: Ultrastructural Pathology - June 30, 2009 Category: Pathology Authors: Magalhães RF, Urso Pitassi LH, Lania BG, Barjas-Castro ML, Neves Ferreira Velho PE Tags: Ultrastruct Pathol Source Type: journals