Basal Cell CarcinomaThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

• By Date
• Specialty Filter
• Discussions
• Top 20

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  

Initial presentation of stasis dermatitis mimicking solitary lesions: A previously unrecognized clinical scenarioEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Stasis dermatitis may present as a solitary lesion mimicking a neoplasm. Early recognition of stasis dermatitis can lead to appropriate treatment and possibly prevent further morbidity. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 19, 2009 Category: Dermatology Authors: Joshua Weaver, Steven D. Billings Tags: Dermatopathology Source Type: journals

Are patients with non-muscle-invasive bladder cancer a suitable population for a lung cancer screening trial?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To estimate the relative risk of developing a second primary neoplasm, in particular lung cancer, after having non-muscle-invasive bladder cancer (NMIBC). Patients were included in the study if they had developed NMIBC between 1995 and 2003. All clinical data were extracted from the medical records of our institution's database. The interval between neoplasms, smoking habits, histological subtypes and survival were also analysed. Patient follow-up was [ge]5 years. We found 231 patients with NMIBC, 39 of which had a second primary neoplasm: 10 lung cancer, one pancreas, one gastric, one pharynx, one liver, one parathyroid, ...
Source: BJU International - November 17, 2009 Category: Urology & Nephrology Authors: Javier del Rey, José Placer, Felip Vallmanya, Núria Pujol, Esther Prat, Rosa Miró, Antoni Gelabert Source Type: journals

Contribution of Dermatologic Surgery in WarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report outlines the important contribution of dermatologic surgery in the combat environment. The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - November 13, 2009 Category: Dermatology Authors: MAJOR J. SCOTT HENNING, BAHAR F. FIROZ Source Type: journals

Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma: further explanation of a dose-escalating pilot study conducted primarily to consider the safety of this pharmacological modificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 10, 2009 Category: Dermatology Authors: A. Curnow, S.M. Campbell Source Type: journals

Factors affecting histological tumour-free margin after excision of Basal Cell Carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. We underestimated tumour extent at only 4% of margins. The most important factor affecting eventual histological margin was tissue shrinkage. Our novel technique allowed us to demonstrate that this shrinkage is not uniform across the specimen, but is disproportionately high in the tumour free margin. This suggests that previous estimates of margin shrinkage, based on whole-specimen contraction measurements, may have been erroneously low. PMID: 19906070 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 10, 2009 Category: Dermatology Authors: Blasdale C, Charlton FG, Weatherhead SC, Ormond P, Lawrence CM Tags: Br J Dermatol Source Type: journals

Multiple primary malignancies in patients with Merkel cell carcinoma1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our figures reflect a higher incidence of multiple malignancies in those with Merkel cell tumour than has previously been reported. This has important implications for the care and surveillance of these patients. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - November 9, 2009 Category: Dermatology Authors: JK Gass, SK Chan, E Rytina, DC Greenberg, NP Burrows Source Type: journals

Fractionated 5-aminolevulinic acid photodynamic therapy in the treatment of a giant recurrent superficial basal cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Photodermatology, Photoimmunology and Photomedicine)
Source: Photodermatology, Photoimmunology and Photomedicine - November 9, 2009 Category: Radiology Authors: Eleni Sotiriou, Zoi Apalla, Demetris Ioannides Tags: Letters to the Editor Source Type: journals

Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma: further explanation of a dose-escalating pilot study conducted primarily to consider the safety of this pharmacological modification.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19903172 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 9, 2009 Category: Dermatology Authors: Curnow A, Campbell SM Tags: Br J Dermatol Source Type: journals

Cloning of the Human GLI2 Promoter: TRANSCRIPTIONAL ACTIVATION BY TRANSFORMING GROWTH FACTOR-{beta} VIA SMAD3/{beta}-CATENIN COOPERATION [Transcription, Chromatin, and Epigenetics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report herein that TGF-β-driven GLI2 expression is transcriptional and does not result from stabilization of GLI2 transcripts. We describe the characterization of the 5'-flanking sequence of human GLI2 mRNA, the identification of a transcription start site, the cloning of ~1,600 bp of the regulatory promoter region and the identification and functional analysis of a TGF-β-responsive region mapped to a 91-bp sequence between nucleotides –119 and –29 of the promoter. This region harbors SMAD and lymphoid enhancer factor/T cell factor binding sites that allow functional cooperation between SMAD3 and &...
Source: Journal of Biological Chemistry - November 6, 2009 Category: Chemistry Authors: Dennler, S., Andre, J., Verrecchia, F., Mauviel, A. Tags: Transcription, Chromatin, and Epigenetics Source Type: journals

Pulmonary Metastasis from a Giant Polypoid Basal Cell Carcinoma in the Lumbosacral AreaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - November 4, 2009 Category: Dermatology Authors: JUNG RYUL KIM, NAE HO LEE, YOUNG SIN KIM, JONG HYUK PARK, SEOK KWEON YUN Source Type: journals

Elevated Expression Levels of Testis Specific Genes, TEX101 and SPATA19 in Basal Cell Carcinoma and their Correlation with Clinical and Pathological Features.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: Here we report 5 new CT antigens, from which, SPATA19 and TEX101 can be possible targets for cancer immunotherapy and novel markers for BCC early detection. PMID: 19886887 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 3, 2009 Category: Dermatology Authors: Ghafouri-Fard S, Abbasi A, Moslehi H, Faramarzi N, Taba Taba Vakili S, Mobasheri MB, Modarressi MH Tags: Br J Dermatol Source Type: journals

Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, skin biopsies from both healthy-looking and lesional skin of patients with psoriasis and superficial spreading BCC were collected and the expression of PAR-2 immunoreactivity in tryptase-positive mast cells was analysed. PAR-2 expression was confirmed in vitro in different mast cell populations. Cord-blood derived mast cells (CBMC) were stimulated with a PAR-2 activating peptide, 2-furoyl-LIGRLO-NH2. Consequently, IL-8 and histamine production was analysed in the supernatants. We observed a significant increase in the percentage of mast cells expressing PAR-2 in the lesional skin of psoriasis and BCC patient...
Source: Experimental Dermatology - November 2, 2009 Category: Dermatology Authors: Ricardo Filipe da Silva Carvalho, Gunnar Nilsson, Ilkka Tapani Harvima Source Type: journals

Basal Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We read with interest the recent article by Auw-Haedrich et al in which they set out to recommend an appropriate and reliable histological safety margin in the surgical excision of periorbital basal cell carcinoma (BCC). The authors conclude that in certain cases of incomplete excision where re-excision may lead to functional or cosmetic morbidity it may be reasonable to observe. This conclusion is based on their data of 11 patients with incompletely excised tumors of which 27% recurred. (Source: Ophthalmology)
Source: Ophthalmology - November 1, 2009 Category: Opthalmology Authors: Paul S. Cannon, Shyamala C. Huilgol, Dinesh Selva, Raman Malhotra Tags: Letters to the Editor Source Type: journals

Author replyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We are grateful to Cannon et al for their valuable comments on our study. For the patient's management it is important to differentiate between solid and fibrous basal cell carcinoma (BCC). We emphasize that we routinely re-excise cases with incompletely excised BCC, as we've recommended in our discussion. Even in solid BCC, when the histological margins are small (under 80 μm), we prefer to re-excise rather than leave a small histological safety margin. However, we believe our study's results could serve as a basis for discussing alternative approaches deserving of consideration when clinicians have to treat patients who...
Source: Ophthalmology - November 1, 2009 Category: Opthalmology Authors: Claudia Auw-Haedrich, Stefanie Frick, Daniel Boehringer, Hans Mittelviefhaus Tags: Letters to the Editor Source Type: journals

Cutaneous Manifestations in Renal Transplant Recipients of Santiago, ChileEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study 58% of patients developed cutaneous side effects of immunosuppressive drugs. Among the evaluated patients, 16% showed premalignant or malignant manifestations on physical examination. The most frequent manifestations were actinic keratosis (17%), basal cell carcinoma (1%), and squamous cell carcinoma (1%). On a retrospective analysis, 12% of patients developed skin cancer after transplantation, 66% squamous cell carcinoma and 34% basal cell carcinoma, with a ratio of 1.9 to 1.Discussion: Cutaneous manifestations in renal transplant recipients are generally secondary to immunosuppression. These patients show a...
Source: Transplantation Proceedings - November 1, 2009 Category: Transplant Surgery Authors: M. Sandoval, M. Ortiz, C. Díaz, D. Majerson, M. Molgó Tags: Renal Transplantation Source Type: journals

Vulval location: an indication for staging in basal cell carcinoma?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19916978 [PubMed - in process] (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - November 1, 2009 Category: Dermatology Authors: Suarez-Amor O, Monteagudo B, Cabanillas M, de las Heras C Tags: Australas J Dermatol Source Type: journals

Treatment of cutaneous tumors with topical 5% imiquimod creamEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our experience confirms imiquimod as an effective treatment option for several types of cutaneous tumors, especially in patients without the cutaneous comorbidities cited above and with low-risk tumors. Imiquimod has a relatively low cost compared to other therapeutic options and can be delivered via ambulatory care to patients with surgery contraindications, and its side effects are tolerable. (Source: Clinics)
Source: Clinics - October 30, 2009 Category: Journals (General) Source Type: journals

Cytokeratin expression patterns in multiple infundibulocystic basal cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of multiple IBCC which developed on a patient's scalp by performing histopathological and immunohistochemical examinations, using monoclonal antibodies against cytokeratins (CKs). A 76-year-old female had noticed multiple small papules on her scalp. She noticed that the tumors were growing when she underwent systemic chemotherapy for metastatic lung cancer. Routine histopathological specimens from skin biopsies revealed findings typical of IBCC. The tumor cells expressed CK14 and CK17. However, CK1 and CK10 were expressed only in a few cells in the inner area of the tumors. The present case is unique in tw...
Source: Journal of Cutaneous Pathology - October 27, 2009 Category: Pathology Authors: Tokimasa Hida, Kenji Saga, Tetsunori Kimura Source Type: journals

Five-Year Cycle of Basal Cell Carcinoma Management Re-audit.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There was no evidence of significant recurrence to justify the 5-years' follow-up. Patients with histologically cleared tumours and satisfactory functional and cosmetic reconstruction outcome can safely be discharged to their GP and should be re referred for new lesions. The functional and cosmetic outcome of the reconstruction was generally satisfactory. PMID: 19839887 [PubMed - in process] (Source: Orbit)
Source: Orbit - October 22, 2009 Category: Opthalmology Authors: Stafanous S Tags: Orbit Source Type: journals

[Myasis associated with nasal basal cell carcinoma.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19853835 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)
Source: Acta Otorrinolaringologica Espanola - October 22, 2009 Category: ENT & OMF Authors: Tamarit-Conejeros JM, Cuesta González MA, Dalmau Galofre J Tags: Acta Otorrinolaringol Esp Source Type: journals

Probing tumor and peritumoral tissues in superficial and nodular basal cell carcinoma using polarized Raman microspectroscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reports the use of polarized Raman microspectroscopy on the nodular and superficial types to discriminate between healthy epidermis and tumor, and between normal and peritumoral stroma. This technique probes additional information than conventional Raman spectroscopy because it is sensitive to the molecular ordering of tissue components. Depolarization ratios and hierarchical cluster analysis demonstrate that polarized Raman microspectroscopy can better identify the tumor and the peritumoral dermis than conventional Raman microspectroscopy, and hence gives potential complementary data about their molecular chara...
Source: Experimental Dermatology - October 20, 2009 Category: Dermatology Authors: Elodie Ly, Anne Durlach, Frank Antonicelli, Philippe Bernard, Michel Manfait, Olivier Piot Source Type: journals

An Unusual Presentation of an Odontogenic Keratocyst in the Buccal Space: Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Odontogenic keratocysts occur predominately in the mandible and maxilla. There are reports of gingival cysts with the histologic features of odontogenic keratocysts that have been termed peripheral odontogenic keratocyst. The location of these cysts in the gingiva supports the concept of their genesis from remnants of the dental lamina found in the gingiva or from the basal cells of the oral epithelium. There are also reports of odontogenic keratocysts in the soft tissues of the head and neck having spread from the maxilla or mandible and cutaneous keratocysts associated with nevoid basal cell carcinoma syndrome. There is ...
Source: Journal of Oral and Maxillofacial Surgery - October 20, 2009 Category: ENT & OMF Authors: Harry V. Precheur, Sigurds O. Krolls Tags: Case Reports Source Type: journals

Therapeutic resistance: Smoothing the wayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Reviews Cancer 9, 768 (2009). doi:10.1038/nrc2751 Author: Sarah Seton-Rogers There is a compelling rationale for using hedgehog pathway inhibitors to treat both medulloblastoma and basal cell carcinoma. Phase I clinical trial data in basal cell carcinoma and a case study of a patient with medulloblastoma reported recently in the New England Journal of Medicine (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - October 14, 2009 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: journals

Occupational exposure to non-artificial UV-light and non-melanocytic skin cancer – a systematic review concerning a new occupational diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The association between occupational UV exposure and SCC is well and consistently documented epidemiologically (approximately 2-fold increased risk), so that the criteria for a new occupational disease are fulfilled. The association with BCC is unclear due to significant methodological limitations in the published studies. (Source: JDDG)
Source: JDDG - October 12, 2009 Category: Dermatology Authors: Jochen Schmitt, Thomas Diepgen, Andrea Bauer Source Type: journals

Simulations of measured photobleaching kinetics in human basal cell carcinomas suggest blood flow reductions during ALA-PDTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a recently completed pilot clinical study at Roswell Park Cancer Institute, patients with superficial basal cell carcinoma (sBCC) received topical application of 20% 5-aminolevulinic acid (ALA) and were irradiated with 633 nm light at 10-150 mW cm-2. Protoporphyrin IX (PpIX) photobleaching in the lesion and the adjacent perilesion normal margin was monitored by fluorescence spectroscopy. In most cases, the rate of bleaching slowed as treatment progressed, leaving a fraction of the PpIX unbleached despite sustained irradiation. To account for this feature, we hypothesized a decrease in blood flow during ALA-photodynamic ...
Source: Lasers in Surgery and Medicine - October 1, 2009 Category: Laser Surgery Authors: Ken Kang-Hsin Wang, William J. Cottrell, Soumya Mitra, Allan R. Oseroff, Thomas H. Foster Source Type: journals

Sunscreen abuse for intentional sun exposure.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Skin cancer is caused by exposure to ultraviolet radiation (UV) and the sun is the main source of this radiation. Sunscreens were initially formulated to prevent sunburns; laboratory studies later revealed that in rodents they could reduce UV-induced skin cancer which resembles human squamous cell carcinoma. Three randomized trials in older adults showed the ability of sunscreens to moderately reduce the occurrence of solar keratoses and of squamous cell carcinoma. However, no effect was observed for basal cell carcinoma. There is no animal model for human melanoma and observational studies often found sunscreen use as...
Source: The British Journal of Dermatology - October 1, 2009 Category: Dermatology Authors: Autier P Tags: Br J Dermatol Source Type: journals

Prevention of non-melanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case-control study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BACKGROUND: Skin cancers represent a major challenge within the ever growing group of long time surviving organ transplant recipients (OTR) world wide. Especially UV-induced non-melanoma skin cancers (NMSC) like invasive squamous cell carcinomas (SCC) and actinic keratoses (AK), and basal cell carcinoma (BCC), outnumber every other form of cancer in organ transplant recipients. Despite encouraging reports of protective effects of broad-spectrum sunscreens in immunocompetent patients, evidence for the prevention of NMSC in immunocompromised patients is still missing. OBJECTIVES: To assess preventive effects of regular s...
Source: The British Journal of Dermatology - October 1, 2009 Category: Dermatology Authors: Ulrich C, Jürgensen JS, Degen A, Hackethal M, Ulrich M, Patel MJ, Eberle J, Terhorst D, Sterry W, Stockfleth E Tags: Br J Dermatol Source Type: journals

UV-induced squamous cell carcinoma--a role for antiapoptotic signalling pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The incidence of nonmelanoma skin cancer including squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) has dramatically increased in the last decades, and chronic sun exposure was identified as a main etiologic agent. UV radiation may produce DNA damage either directly or through reactive oxygen species (ROS). As mutations caused by UV may lead to skin cancer due to oncogene activation and tumor suppressor gene inactivation, efficient safeguard mechanisms have been developed during evolution. These enclose induction of apoptosis and formation sunburn cells aiming at the removal of premalignant cells. The kerat...
Source: The British Journal of Dermatology - October 1, 2009 Category: Dermatology Authors: Rodust PM, Stockfleth E, Ulrich C, Leverkus M, Eberle J Tags: Br J Dermatol Source Type: journals

Hereditary hair loss and the ancient signaling pathways that regulate ectodermal appendage formation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
All epidermal appendages, including hair, teeth, and nails, begin as a thickening of the ectoderm, called a placode. The placode arises from a primary induction signal that is sent from the underlying mesenchyme to the overlying epidermis. In mammals, the precise arrangement of hair follicles in the skin is due to the amount and distribution of signals that promote and inhibit hair placode formation. Continued development of a hair follicle after placode formation requires a complex cross-talk between the mesenchyme and epidermis. Here, I will review recent studies in humans and mice that have increased our understandi...
Source: Clinical Genetics - September 30, 2009 Category: Genetics & Stem Cells Authors: Van Raamsdonk CD Tags: Clin Genet Source Type: journals

Ocular metastasis of cutaneous malignant melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The primary care optometric setting, by the way a patient's visual symptoms present or the appearance of fundus abnormalities, can offer the capability of first detection and referral for the discovery of metastatic lesions. Although orbital metastasis is considered a terminal finding in these cases, timely diagnosis enables, while limited, the best options for management. (Source: Optometry - Journal of the American Optometric Association)
Source: Optometry - Journal of the American Optometric Association - September 30, 2009 Category: Opthalmology Authors: Tehseena Ullah, Andrew S. Gurwood, Marc D. Myers Tags: Clinical Care Source Type: journals

Hedgehog Pathway Inhibitor Helps Fight CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new drug that inhibits the hedgehog signaling pathway has shown “remarkable” antitumor activity against basal cell carcinoma and medulloblastoma, according to two reports. The hedgehog signaling pathway regulates cell growth and differentiation during early development but is inactive in healthy adults. However, it appears that mutations in components of the pathway can cause malignant growth in some cases of medulloblastoma, the most common brain cancer in children, and in several cancers in adults, notably basal cell carcinoma. (Source: Skin and Allergy News)
Source: Skin and Allergy News - September 30, 2009 Category: Dermatology Authors: MARY ANN MOON Tags: Cutaneous Oncology Source Type: journals

Cutaneous leishmaniasis of the eyelid masquerading as basal cell carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cutaneous leishmaniasis of the eyelid masquerading as basal cell carcinoma. Can J Ophthalmol. 2009 Oct;44(5):e47 Authors: Jaouni T, Deckel Y, Frenkel S, Ilsar M, Pe'er J PMID: 19798817 [PubMed - in process] (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - September 30, 2009 Category: Opthalmology Authors: Jaouni T, Deckel Y, Frenkel S, Ilsar M, Pe'er J Tags: Can J Ophthalmol Source Type: journals

Ocular metastasis of cutaneous malignant melanoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The primary care optometric setting, by the way a patient's visual symptoms present or the appearance of fundus abnormalities, can offer the capability of first detection and referral for the discovery of metastatic lesions. Although orbital metastasis is considered a terminal finding in these cases, timely diagnosis enables, while limited, the best options for management. PMID: 19801341 [PubMed - in process] (Source: Optometry)
Source: Optometry - September 30, 2009 Category: Opthalmology Authors: Ullah T, Gurwood AS, Myers MD Tags: Optometry Source Type: journals

Longstanding lupus vulgaris with basal cell carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19805990 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - September 30, 2009 Category: Pathology Authors: Kate MS, Dhar R, Borkar DB, Ganbavale DR Tags: Indian J Pathol Microbiol Source Type: journals

[Microcystic adnexal carcinoma: mohs micrographic surgery as the treatment of choice.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The absence of perineural involvement and substantial cell atypia can be attributed to the lesions being primary tumors. This would provide a rationale for definitive radical treatment of the primary tumor from the outset to avoid the complications associated with recurrence. The site and the absence of recurrence in all our patients who underwent Mohs micrographic surgery support the use of this technique as the treatment of choice in microcystic adnexal carcinoma. PMID: 19775547 [PubMed - in process] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - September 26, 2009 Category: Dermatology Authors: Martorell-Calatayud A, Requena-Caballero C, Botella-Estrada R, Almenar-Medina S, Sanmartín-Jiménez O, Llombart-Cussac B, Nagore-Enguídanos E, Serra-Guillén C, Echeverría-García B, Guillén-Barona C Tags: Actas Dermosifiliogr Source Type: journals

[CD1a+ Langerhans Cells in the Peritumoral Epidermis of Basal Cell Carcinoma.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The lower density and fewer morphological changes of LCs in the epidermis overlying BCC may give rise to alterations in the immune response to BCC. Digital image analysis is a reliable method for the morphometric evaluation of LCs. PMID: 19775548 [PubMed - in process] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - September 26, 2009 Category: Dermatology Authors: Mardones F, Zemelman V, Zemelman V, Sazunic I, Sazunic I, Morales C, Morales C, Palma K, Palma K, Vargas M, Vargas M Tags: Actas Dermosifiliogr Source Type: journals

Tumorigenesis: No frills attachedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Reviews Cancer 9, 685 (2009). doi:10.1038/nrc2739 Author: Gemma K. Alderton Primary cilia are sites of regulation of the Hedgehog (HH) pathway, deregulation of which can cause basal cell carcinoma (BCC) or medulloblastoma. Two groups provide evidence that primary cilia have a functional role in modulating oncogenic HH signalling.HH binding to its receptor, patched ( (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 24, 2009 Category: Cancer & Oncology Authors: Gemma K. Alderton Tags: Research Highlight Source Type: journals

Radiotherapy for basal cell carcinoma of the medial canthus regionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To report outcome for patients treated with radiotherapy (RT) for basal cell carcinoma of the medial canthus.Retrospective review.Thirty-three patients treated with RT at the University of Florida between 1965 and 2005 for basal cell carcinoma of the medial canthus were retrospectively reviewed. RT was the primary treatment for gross disease in 70% of patients and for positive margin after resection in 30%. The prescribed dose was 50 to 60 Gy at 2.0 to 2.5 Gy per fraction.Surviving patients were followed for a median of 14 years. Tumor recurred at the primary site in 10%. There were no regional recurrences or distant metas...
Source: The Laryngoscope - September 23, 2009 Category: ENT & OMF Authors: Erika L. Swanson, Robert J. Amdur, William M. Mendenhall, Christopher G. Morris, Jessica M. Kirwan, Franklin Flowers Source Type: journals

PTH-independent hypercalcaemia and non-melanoma skin cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions PTH-independent hypercalcaemia has a low prevalence in SCC patients. Hypercalcaemia is correlated with susceptibility to develop metastases in SCC. A possible mechanism is PTHrp hypersecretion by malignant keratinocytes. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - September 22, 2009 Category: Dermatology Authors: I Nicolae, S Schipor Source Type: journals

One-stage reconstruction of the entire upper lip and the columella with a modified bilateral nasolabial flapEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a modification of the nasolabial flap technique using cheek tissue for the reconstruction of the defect. The modified flap is used for both the full-thickness reconstruction of the subtotal upper-lip defect and the restoration of the function and appearance of the columella. This technique allows excellent cosmetic and functional results to be obtained in a single-stage procedure. Content Type Journal ArticleCategory MiscellaneousDOI 10.1007/s00405-009-1104-7Authors Kai Johannes Lorenz, German Armed Forces Hospital Department of Otolaryngology-Head and Neck Surgery Oberer Eselsberg 40 89081 Ulm GermanyH...
Source: European Archives of Oto-Rhino-Laryngology - September 21, 2009 Category: ENT & OMF Tags: European Archives of Oto-Rhino-Laryngology Source Type: journals

Immunolocalisation of laminin-1 in keratocystic odontogenic tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Keratocystic odontogenic tumors (KOTs) are distinct odontogenic lesions frequently affecting the jawbones. They may be associated with nevoid basal cell carcinoma syndrome (NBCCS), and may exhibit disorders involving the extracellular matrix. The aim of this study was to investigate the immunolocalisation of laminin-1 in 20 cases of KOTs in order to contribute to the characterization of this protein, which is little studied in odontogenic tumors. Our results showed laminin-1 in all 20 KOTs studied; its labelling intensity was weak in three cases (15%), moderate in five (25%) and strong in 12 cases (60%). Laminin-1 immu...
Source: Acta Histochemica - September 18, 2009 Category: Biochemistry Authors: Silva Gurgel CA, Gonçalves Ramos EA, Araújo Melo L, Brandi Schlaepfer C, de Souza RO, Campos Oliveira M, Dos Santos JN Tags: Acta Histochem Source Type: journals

Mohs Surgery for Basal Cell Carcinoma Assisted by Dermoscopy: Report of Two CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - September 16, 2009 Category: Dermatology Authors: VITALY TERUSHKIN, STEVEN Q. WANG Source Type: journals

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The hedgehog pathway is active during embryonic development but dormant after birth. Mutations constitutively activate hedgehog genes in basal-cell carcinoma. This phase 1 trial tested the safety and antitumor activity of an inhibitor of the hedgehog pathway (GDC-0449) in patients with locally advanced or metastatic basal-cell carcinoma whose tumors were inoperable or had not responded to previous therapy. The drug appeared to have antitumor activity in patients with basal-cell carcinoma. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - September 15, 2009 Category: Internal Medicine Authors: Von Hoff, D. D., LoRusso, P. M., Rudin, C. M., Reddy, J. C., Yauch, R. L., Tibes, R., Weiss, G. J., Borad, M. J., Hann, C. L., Brahmer, J. R., Mackey, H. M., Lum, B. L., Darbonne, W. C., Marsters, J. C., de Sauvage, F. J., Low, J. A. Tags: ORIGINAL ARTICLES Source Type: journals

Potential Skin Cancer Breakthrough Tested At Scottsdale Healthcare Published Today In New England Journal Of MedicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A study published in the New England Journal of Medicine reports a potential new investigational therapy for advanced and metastatic basal cell skin cancer tested at the Virginia G. Piper Cancer Center at Scottsdale Healthcare and other sites appears to demonstrate tumor shrinkage and limited side effects in patients. "Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma" is authored by lead investigator Daniel D. Von Hoff, MD, a world-renowned expert in developing new drugs for patients with cancer. Dr. Von Hoff is an oncologist and chief scientific officer at the Virginia G. Piper Cancer Center at Scottsda...
Source: Cancercompass News: Other Cancer - September 15, 2009 Category: Cancer & Oncology Source Type: news

Pigmented reticular structures in basal cell carcinoma and collision tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The presence of a pigment network in the context of a BCC is uncommon, and it usually reflects the association of BCC with a solar lentigo, naevus or a specific location of the lesion on photodamaged skin. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - September 14, 2009 Category: Dermatology Authors: A. Gulia, D. Altamura, S. De Trane, T. Micantonio, M.C. Fargnoli, K. Peris Source Type: journals

Pigmented reticular structures in basal cell carcinoma and collision tumours.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The presence of a pigment network in the context of a BCC is uncommon, and it usually reflects the association of BCC with a solar lentigo, naevus or a specific location of the lesion on photodamaged skin. PMID: 19754866 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 14, 2009 Category: Dermatology Authors: Gulia A, Altamura D, De Trane S, Micantonio T, Fargnoli MC, Peris K Tags: Br J Dermatol Source Type: journals

Sebaceous lesions and their associated syndromes: Part IEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discusses the clinical and pathologic features of sebaceous hyperplasia, nevus sebaceous of Jadassohn, sebaceous adenoma, seboacanthoma, sebaceous epithelioma, sebaceoma, mantleoma, basal cell carcinoma with sebaceous differentiation, sebomatricoma (sebomatrixoma), and sebaceous carcinoma. Controversies regarding these lesions will be explored, and any relationship with Muir–Torre syndrome will be discussed.Learning objectives: After completing this learning activity, participants should be able to discuss controversies regarding the nomenclature of sebaceous neoplasms, discuss management strategies regardin...
Source: Journal of the American Academy of Dermatology - September 14, 2009 Category: Dermatology Authors: Daniel B. Eisen, Daniel J. Michael Tags: Continuing Medical Education Source Type: journals

An unusual basal cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the case of a 62-year-old woman who presented a histological diagnostic conundrum. The patient presented with a four year history of a slow growing painless papular lesion on her left nostril. On clinical examination, a firm, red lesion 15mm in diameter was located just lateral to the left nostril, penetrating deeply beneath the alar base to involve the nasal sill. It was palpable from the inner aspect of the lip. Biopsy suggested the diagnosis of basal cell carcinoma. This was compatible with the clinical appearance. However histological examination of the excised lesion showed that it was either a trichoblasto...
Source: The British Journal of Oral & Maxillofacial Surgery - September 11, 2009 Category: ENT & OMF Authors: Ihsaan Al-Hadad, A. Chadha, C. Liew, A. Robson, G. Bounds Tags: On-line Only Abstracts Source Type: journals

Determination of the relationship between basal cell carcinoma and human papilloma virus, based on immunohistochemistry staining methodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: </b> In this study we did not find a significant relationship between BCC and HPV, but based on review of articles it appears that large multicentric studies are to be conducted in this regard. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - September 10, 2009 Category: Dermatology Authors: Mokhtari M, Mesbah A, Rajabi P, Rajabi M Ali, Chehrei A, Mougouei K Source Type: journals

Histology-based treatment of basal cell carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Basal cell carcinoma is the most common type of skin cancer and its incidence is still rising. In recent years, new treatment modalities have been developed and existing modalities refined. The aim of this article is to give a histology-based overview of the available evidence-based research. The literature was searched for randomized controlled trials from which the efficacy of investigated treatments was obtained. Where possible, treatment modalities were evaluated specifically. Selection criteria were histological subtype, primary or recurrent basal cell carcinoma and tumour localization. Although surgery remains th...
Source: Acta Derm Venereol A... - September 9, 2009 Category: Dermatology Authors: Mosterd K, Arits AH, Thissen MR, Kelleners-Smeets NW Tags: Acta Derm Venereol Source Type: journals