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Reply to the Editor
In their letter, Koster and coworkers refer to our recent articles on a comprehensive blood-sparing approach in pediatric cardiac surgery and the effects of this approach on blood transfusion incidence and on potential effects of blood transfusion on postoperative morbidity. They propose a pair of simple but plausible mechanisms to explain how morbidity may contribute to the need for blood transfusion, rather than vice versa. The first is based on the well-known vasodilatory effect of analgosedation. We fully agree that the resulting volume treatment could induce hemodilution to such an extent that it would contribute to t...
Source: The Journal of Thoracic and Cardiovascular Surgery - May 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Matthias Redlin, Marian Kukucka, Wolfgang Boettcher, Helge Schoenfeld, Michael Huebler, Hermann Kuppe, Helmut Habazettl Tags: Letters to the Editor Source Type: research

The effects of ‘old’ red blood cell transfusion on mortality and morbidity in elderly patients with hip fractures – A retrospective study
Conclusion: Patients undergoing surgery for hip fractures who received ‘old’ units of blood did not differ from those receiving ‘new’ units with regard to mortality and morbidity. Large-scale clinical trials are needed to further investigate this association. (Source: Injury)
Source: Injury - May 15, 2013 Category: Orthopaedics Authors: Assaf Kadar, Ofir Chechik, Eldad Katz, Itay Blum, Gabrielle Meghiddo, Moshe Salai, Ely Steinberg, Amir Sternheim Tags: Clinical Papers – Proximal femoral fractures Source Type: research

Abstract 198: Racial Disparity In Resuming Anticoagulation For Atrial Fibrillation After An Episode Of Major Gastrointestinal Bleeding [Poster Session II]
Conclusion: In conclusion, the racial disparity in resuming warfarin after an episode of major GIB in anticoagulated patients for atrial fibrillation was more for Caucasians than African American. This may be explained by uncertainty of outcomes that frequently leads to overtreatment of minority patients. Cultural beliefs for not resuming warfarin might have also played a role. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Qureshi, W., Garikapati, K., Patsias, I., Cheema, G., Mittal, C., Alirhayim, Z., Paje, D. Tags: Poster Session II Source Type: research

Distraction by a monotube fixator to achieve limb lengthening: predictive factors for tibia trauma
Conclusion: Distraction by a monotube fixator appears effective in achieving correction >38.0% original tibia lengthening following traumatic bone gap. Predictive factors for poor outcome were useful for prognostication. (Source: Journal of Trauma Management and Outcomes)
Source: Journal of Trauma Management and Outcomes - May 14, 2013 Category: Emergency Medicine Authors: Olayinka AdegbehingbeOwolabi OjoPaul AbiolaAbimbola AriyibiLawrence OginniJohn Obateru Source Type: research

How important is transfusion avoidance in 2013?
Prior to the advent of recombinant erythropoietin in the late-1980s, blood transfusions were the mainstay of anaemia management in patients with end-stage renal failure, many of whom required "top-up" transfusions every 2 to 4 weeks to relieve the debilitating symptoms of severe anaemia. Erythropoietin therapy, however, allowed for the first time, such patients to achieve a sustained correction of anaemia, and there was a dramatic fall in both the use of red cell transfusions in dialysis units, as well as the associated transfusional iron overload prevalent in dialysis patients. Avoidance of blood transfusions improved acc...
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Macdougall, I. C., Obrador, G. T., El Nahas, M. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Is single-unit blood transfusion bad post-coronary artery bypass surgery?
CONCLUSIONS Cox regression and propensity matching both indicate that a single-unit transfusion is not a significant cause of reduced long-term survival. Preoperative anaemia is a significant confounding factor. Despite demonstrating the negligible risks of a single-unit blood transfusion, we are not advocating liberal transfusion and would recommend changing from a double-unit to a single-unit transfusion policy. We speculate that blood is not bad, but that the underlying reason that it is given might be. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - May 14, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Warwick, R., Mediratta, N., Chalmers, J., Pullan, M., Shaw, M., Mcshane, J., Poullis, M. Tags: Adult Cardiac Source Type: research

The effect of retrograde autologous priming volume on haemodilution and transfusion requirements during cardiac surgery
CONCLUSIONS Retrograde autologous priming is an effective adjunct to decrease the blood transfusion rate, coping with the CPB-related haemodilution and its adverse clinical effects. A RAP volume individualized to each patient offers most benefit as part of a multidisciplinary blood conservation approach. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - May 14, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Vandewiele, K., Bove, T., De Somer, F. M. J. J., Dujardin, D., Vanackere, M., De Smet, D., Moerman, A. T., Bouchez, S., Francois, K. Tags: Adult Cardiac Source Type: research

Strategic and operational aspects of a transfusion-free neonatal arterial switch operation
We report an overview of the literature regarding blood transfusion-free complex congenital cardiac surgery. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - May 14, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Schweiger, M., Dave, H., Kelly, J., Hubler, M. Tags: Congenital Source Type: research

Thalassaemia major and the heart: a toxic cardiomyopathy tamed?
Introduction Disorders of haemoglobin synthesis, such as thalassaemia, are the most common monogenetic disorders worldwide. When first described, thalassaemia major (TM) was universally fatal in childhood, but after the adoption of regular blood transfusion, survival until early teenage and adulthood was to be expected. Sadly as these individuals aged organ failure followed, due to the accumulated iron secondary to regular blood transfusion. Principal among the tissues affected by iron overload is the heart and even to the present day, heart disease accounts for the overwhelming majority of premature deaths in this populat...
Source: Heart - May 13, 2013 Category: Cardiology Authors: Walker, J. M. Tags: Reviews Source Type: research

The perioperative course of factor XIII and associated chest tube drainage in newborn and infants undergoing cardiac surgery
ConclusionFactor XIII activity in infants with congenital heart defects is within the lower range of normal adults, independent of patient's age and the presence of cyanosis. Reconstituted blood prime maintains factor XIII activity at sufficient levels during pediatric cardiac surgery. We could not detect a correlation between FXIII and CTD. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - May 13, 2013 Category: Anesthesiology Authors: Ralph Gertler, Klaus Martin, Alexander Hapfelmeier, Peter Tassani‐Prell, Siegmund Braun, Gunther Wiesner Tags: Original Article Source Type: research

What Precautions Should Be Used for a Child Whose Parent is Hepatitis C Positive?
Discussion Hepatitis C virus (HCV) is a single-stranded RNA Flavivus that was first identified in 1989 and universal screening in the blood supply was begun in 1992 in the United States. Overall incidence of acute HCV in children under age 19 is 0.1 per 100,000. In adults, the transmission is mainly from contaminated blood and body fluids, primarily intravenous drug use. It is the most common reason for liver transplantation in adults. Of those that acquire the acute infection, about 70% go on to become chronically infected. Adults have a slow progression of their disease with 20% having cirrhosis within 20 years. Being ma...
Source: PediatricEducation.org - May 12, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

External quality assessment of human neutrophil antigen (HNA)‐specific antibody detection and HNA genotyping from 2000 to 2012
Since 2000, Quality Assurance (QA) exercises for the detection and identification of granulocyte antibodies and DNA typing for human neutrophil antigens (HNA) have been distributed within the International Granulocyte Immunobiology Workshops, which are linked to International Society of Blood Transfusion. The exercises were standardised at the outset to enable laboratory performance to be monitored. Between 2000 and 2012, nine exercises were distributed to 20 laboratories. Overall, 45 examples of 42 unique samples containing defined granulocyte reactive antibodies were distributed for serological analysis together with 20 ...
Source: Vox Sanguinis - May 11, 2013 Category: Hematology Authors: G. Lucas, L. Porcelijn, Y. L. Fung, F. Green, A. Reil, M. Hopkins, R. Schuller, A. Green, M. Haas, J. Bux Tags: Report Source Type: research

Fitness, the most important factor before my hysterectomy – Vibeke’s Story
My journey of sheer hell started when I was 47 years old. Having had quite light periods all though painful most of my life, my body suddenly turned on me and started bleeding severely. Before I had control and knew when it was coming pretty much to the date, to bleeding ¾ of the month which ranged from spotting to huge clumps of blood coming out and sometimes shooting out of me which really was quite scary. I went to look into what I could do and it appeared that everyone just thought that having a Hysterectomy was the answer. Having read some horror stories about this I was not ready to travel down this road. It was fou...
Source: The Hysterectomy Association - May 9, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Your Stories fitness hysterectomy recovery Source Type: news

Better Outcomes In Anemic Surgical Patients With Fewer Transfusion-Related Complications With Single, High-Dose Erythropoietin
Anemia increases operative mortality and morbidity in non-cardiac and cardiac surgical procedures. Anemic surgical patients may require more blood transfusions, raising the risk of transfusion-related complications and increasing costs. For those reasons, optimizing patient readiness by correcting anemia prior to surgery is an important clinical goal. A simple new protocol has been proposed that helps correcting anemia using a single, high dose of recombinant human erythropoietin (HRE) administered only two days prior to surgery... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 8, 2013 Category: Consumer Health News Tags: Blood / Hematology Source Type: news

Impact of surgical waiting time on paediatric spinal deformity patients
ConclusionIncreased waiting time for surgery has a negative impact on quality of life of patients with scoliosis. (Source: ANZ Journal of Surgery)
Source: ANZ Journal of Surgery - May 8, 2013 Category: Surgery Authors: Riana Calman, Troy Smithers, Robert Rowan Tags: Original Article Source Type: research

Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis
Conclusions: TXA should be considered for routine use in primary knee and hip arthroplasty to decrease blood loss. (Source: BMC Research Notes)
Source: BMC Research Notes - May 7, 2013 Category: Research Authors: Rajiv GandhiHeather EvansSafiyyah MahomedNizar Mahomed Source Type: research

Feasibility of robotic pancreaticoduodenectomy
ConclusionSelected patients can safely undergo robotic pancreaticoduodenectomy. The main downsides are high costs and prolonged operating times compared with open resection. (Source: British Journal of Surgery)
Source: British Journal of Surgery - May 3, 2013 Category: Surgery Authors: U. Boggi, S. Signori, N. De Lio, V. G. Perrone, F. Vistoli, M. Belluomini, C. Cappelli, G. Amorese, F. Mosca Tags: Original article Source Type: research

Analysis of Autologous Platelet-Rich Plasma During Ascending and Transverse Aortic Arch Surgery [ORIGINAL ARTICLES: ADULT CARDIAC]
Conclusions The utilization of aPRP was associated with a reduction in allogeneic blood transfusions as well as a decrease in early postoperative morbidity during repairs of the ascending and transverse arch aorta using PHCA. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Zhou, S.-F., Estrera, A. L., Miller, C. C., Ignacio, C., Panthayi, S., Loubser, P., Sagun, D. L., Sheinbaum, R., Safi, H. J. Tags: Cardiac - pharmacology, Great vessels ORIGINAL ARTICLES: ADULT CARDIAC Source Type: research

Severe cerebral injury in a recipient with twin anemia–polycythemia sequence
We report a case of TAPS detected antenatally by Doppler ultrasound examination at 15 + 6 weeks' gestation. After counseling, the parents opted for expectant management. Regular Doppler measurements were performed and these remained fairly stable. An emergency Cesarean section was performed at 34 + 5 weeks following signs of fetal distress. The donor twin was severely anemic while the recipient twin had severe polycythemia–hyperviscosity syndrome. On day 1, the recipient developed respiratory insufficiency and subclinical status epilepticus. Magnetic resonance imaging showed a total loss of gray–white matt...
Source: Ultrasound in Obstetrics and Gynecology - April 28, 2013 Category: Radiology Authors: E. Lopriore, F. Slaghekke, K. J. Kersbergen, L. S. de Vries, A. P. Drogtrop, J. M. Middeldorp, D. Oepkes, M. J. Benders Tags: Case Report Source Type: research

Giving blood: important in a crisis, important all year long
By Scott Howe Following the tragedy in Boston on Marathon Monday, thousands of people asked, “what can I do to help?” For many, the answer was “give blood.” In fact, the desire to donate in days after the marathon was so great that appointments at the Boston Children’s Blood Donor Center booked up quickly, and many eager donors were asked to schedule future appointments. The generosity was truly remarkable and the donations very much needed. But it also spurred curiosity. More than once I heard someone ask, “How does the blood you donate go on to help others?” The answer is a little more complex than ...
Source: Thrive, Children's Hospital Boston - April 26, 2013 Category: Pediatrics Authors: Guest Blogger Tags: All posts blood donation Blood Donor Center Source Type: news

Well: God and Doctor
When a patient who had refused blood transfusions on religious grounds died quickly, the staff of the leukemia floor was plagued by a question: Had we done enough for him? (Source: NYT Health)
Source: NYT Health - April 25, 2013 Category: Consumer Health News Authors: By MIKKAEL A. SEKERES, M.D. Tags: Chemotherapy Doctors doctor patient relationship Cancer Featured Religion and Belief Source Type: news

DRC: Urgent Action Needed to Prevent Malaria Deaths in Orientale Province
DRC 2012 © Aurelie Lachant/MSF A child is tested for malaria in Orientale Province. APRIL 25, 2013—An upsurge in malaria is likely to have serious consequences for people in Orientale Province in Democratic Republic of Congo (DRC) unless immediate action is taken, the international medical humanitarian organization Doctors Without Borders/Médecins Sans Frontières (MSF) warned on World Malaria Day today. Mosquito nets and medical supplies are urgently needed as the rainy season approaches in a region where malaria is one of the main causes of death. Tackling recurrent outbreaks demands a fi...
Source: MSF News - April 25, 2013 Category: Global & Universal Source Type: news

Literature Review of Passenger Lymphocyte Syndrome Following Renal Transplantation and Two Case Reports
We report two cases of PLS occurring after renal transplantation. Both recipients received live related kidney transplants; one from his mother and the other from his brother. The direction of blood group transfer, from donor to recipient, was O Rh D+ to A Rh D+ in both cases. Approximately 12 days after transplantation, both recipients showed a rapid fall in their hemoglobin levels with no identifiable bleeding source. DAT positive hemolysis was confirmed and anti‐A antibodies were detected in recipient sera, confirming a diagnosis of PLS. Both cases required blood transfusion support to maintain their hemoglobin and bo...
Source: American Journal of Transplantation - April 25, 2013 Category: Transplant Surgery Authors: L. Nadarajah, N. Ashman, R. Thuraisingham, C. Barber, S. Allard, L. Green Tags: Case Report Source Type: research

Inspection finds major deficiencies in quality procedures at blood transfusion service
(Source: The Irish Times - Health)
Source: The Irish Times - Health - April 23, 2013 Category: Consumer Health News Source Type: news

Extreme hyperferritinaemia; clinical causes
There are many causes of raised serum ferritin concentrations including iron overload, inflammation and liver disease to name but a few examples. Cases of extreme hyperferritinaemia (serum ferritin concentration equal to or greater than 10 000 ug/l) are being reported in laboratories but the causes of this are unclear. We conducted an audit study to explore this further. Extreme hyperferritinaemia was rare with only 0.08% of ferritin requests displaying this. The main causes of extreme hyperferritinaemia included multiple blood transfusions, malignant disease, hepatic disease and suspected Still's disease. (Sourc...
Source: Journal of Clinical Pathology - April 21, 2013 Category: Pathology Authors: Crook, M. A., Walker, P. L. C. Tags: Liver disease, Haematology (incl blood transfusion), Immunology (including allergy), Inflammation Short report Source Type: research

Accumulation profiles of PrPSc in hemal nodes of naturally and experimentally scrapie-infected sheep
Conclusion: Despite the anatomical difference in leukocyte trafficking between lymph nodes and hemal nodes, the follicles of hemal nodes appear to process PrPSc similarly to lymph nodes. (Source: BMC Veterinary Research - Latest articles)
Source: BMC Veterinary Research - Latest articles - April 19, 2013 Category: Veterinary Research Authors: Rohana DassanayakeThomas TruscottM Özyi¿itDongyue ZhuangDavid SchneiderKatherine O¿Rourke Source Type: research

Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions
This article focuses on the laboratory, animal, and clinical evidence to date on the mechanistic understanding of inflammatory and immune-modulatory effects of blood products and their significance for recurrence in the cancer surgical patient. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - April 18, 2013 Category: Anesthesiology Authors: Cata, J. P., Wang, H., Gottumukkala, V., Reuben, J., Sessler, D. I. Tags: Review Articles Source Type: research

Post Transfusion Lung Injury in the Neonatal PopulationPost Transfusion Lung Injury in the Neonatal Population
Are blood transfusions associated with the need for increased respiratory support in neonates? Journal of Perinatology : Official Journal of the California Perinatal Association (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 17, 2013 Category: Consumer Health News Tags: Pediatrics Journal Article Source Type: news

West Nile virus in Europe: emergence, epidemiology, diagnosis, treatment, and prevention
Abstract West Nile virus (WNV), a mosquito‐borne flavivirus in the Japanese encephalitis antigenic group, has caused sporadic outbreaks in humans, horses and birds throughout many of the warmer regions of Europe for at least 20 years. Occasional cases of West Nile encephalitis have also been associated with infected blood transfusions and organ donations. Currently, WNV appears to be expanding its geographical range in Europe and causing increasing numbers of epidemics/outbreaks associated with human morbidity and mortality. This brief review reports on the current epidemic situation regarding WNV in Europe, highlightin...
Source: Clinical Microbiology and Infection - April 17, 2013 Category: Microbiology Authors: V. Sambri, M. Capobianchi, R. Charrel, M. Fyodorova, P. Gaibani, E. Gould, M. Niedrig, A. Papa, A. Pierro, G. Rossini, S. Varani, C. Vocale, M. P. Landini Tags: Review Source Type: research

Successful coil embolization for life‐threatening hemorrhage in childhood leukemia induction therapy
Abstract An 11‐year‐old boy was experienced severe life‐threatening hemorrhage from a branch of the superior mesenteric artery (SMA) after acute lymphoblastic leukemia induction therapy. The patient had a history of attention deficit hyperactivity disorder (ADHD), diagnosed at 3 years of age. Subsequent to discontinuing his psychotropic medication, the patient’s mental status deteriorated and treatment with midazolam for 3 weeks was necessary to allow the completion of the leukemia induction regimen. On day 51, although there was no indication of thrombocytopenia or a coagulation disorder, the patient began to hemo...
Source: Pediatrics International - April 16, 2013 Category: Pediatrics Authors: Jun Hayakawa, Takahiro Ueda, Yusuke Fujiwara, Yusuke Ozaki, Satoshi Wakita, Miho Maeda, Yoshitaka Fukunaga Tags: PATIENT REPORT Source Type: research

Thrombelastography (TEG(R)): practical considerations on its clinical use in trauma resuscitation
Conclusions: Thrombelastography has characteristics of an ideal coagulation test for use in early trauma resuscitation. It has limitations, but may prove useful as an additional test. Future studies should evaluate its potential to guide blood transfusion and the understanding of the mechanisms of trauma coagulopathy. (Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine)
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - April 16, 2013 Category: Emergency Medicine Authors: Luis da LuzBartolomeu NascimentoSandro Rizoli Source Type: research

Delivering stents in congenital heart disease using the double wire technique: Technical considerations
Conclusions: The dual wire stenting technique is effective to accurately deliver and anchor stents into lesions close to side branches and bifurcations. Side branch patency is maintained; the clinical objective (gradient relief, aneurysm exclusion, relief of external compression) can safely be reached. Technique and balloon selection should be based on the underlying anatomical substrate. © 2013 Wiley Periodicals, Inc. (Source: Catheterization and Cardiovascular Interventions)
Source: Catheterization and Cardiovascular Interventions - April 16, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Stephen C Brown, Bjorn Cools, Derize E Boshoff, Nazan Özbarlas, Ruth Heying, Werner Budts, Daniël Buys, Marc Gewillig Tags: Original Study Source Type: research

Thrombelastography (TEG®): practical considerations on its clinical use in trauma resuscitation
Conclusions: Thrombelastography has characteristics of an ideal coagulation test for use in early trauma resuscitation. It has limitations, but may prove useful as an additional test. Future studies should evaluate its potential to guide blood transfusion and the understanding of the mechanisms of trauma coagulopathy. (Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine)
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - April 16, 2013 Category: Emergency Medicine Authors: Luis da LuzBartolomeu NascimentoSandro Rizoli Source Type: research

Why a newborn baby's cord should not be cut too soon
In the first minutes after birth, as it starts to breathe on its own, a newborn can receive a substantial blood transfusion from the placenta, says Glenda Cooper (Source: Telegraph Health)
Source: Telegraph Health - April 15, 2013 Category: Consumer Health News Source Type: news

Ultrasonography-guided PNL in comparison with laparoscopic ureterolithotomy in the management of large proximal ureteral stone
Conclusion: According to our study, percutaneous nephrolithotomy under ultrasonography guidance is comparable with the laparoscopic ureterolithotomy for the treatment of proximal ureteral stones larger than 1 cm. (Source: International Braz J Urol)
Source: International Braz J Urol - April 14, 2013 Category: Urology & Nephrology Source Type: research

Alternative techniques to reduce warm ischemia time in laparoscopic partial nephrectomy
Conclusion: Warm ischemia time can be reduced and kidney function can be preserved during laparoscopic nephrectomy if either early unclamping or on demand clamping are selectively applied. (Source: International Braz J Urol)
Source: International Braz J Urol - April 14, 2013 Category: Urology & Nephrology Source Type: research

The race to save Hannah
Hannah After she was stricken with a serious illness almost overnight, and then rushed to Boston Children’s Hospital where in a matter of hours she received multiple treatments—including an extremely rare liver transplant—Hannah Swift could be the most aptly named eleven-year-old in the world. In an age where close monitoring, drugs and advanced therapies can prevent or delay transplant surgeries for weeks or months, Hannah’s story is an amazing example of medical collaboration where every minute counted in saving her life. More than a stomach bug Hannah had been coughing and vomiting for a few days when h...
Source: Thrive, Children's Hospital Boston - April 12, 2013 Category: Pediatrics Authors: Tripp Underwood Tags: All posts Our patients’ stories heapatology Heung Bae Kim Liver transplant our patients' stories Pediatric Transplant Center (PTC) Scott Elisofon Source Type: news

Question 1 * Do feeding practices during transfusion influence the risk of developing necrotising enterocolitis in preterm infants?
Scenario An otherwise well 4-week-old 28-week gestation male infant has a haemoglobin level of 69 g/l associated with a low reticulocyte count. He is currently on full enteral feeds. The medical plan is to give him a blood transfusion, but the nursing staff ask whether feeding should be stopped around the time of transfusion to reduce his chance of developing complications. What is the evidence that feeding practices during transfusion influence the risk of developing transfusion-associated necrotising enterocolitis (TANEC)? Structured clinical question In a preterm infant [patient] with anaemia of prematurity, do fee...
Source: Archives of Disease in Childhood - April 12, 2013 Category: Pediatrics Authors: Keir, A. K., Wilkinson, D. Tags: ADC Archimedes, Clinical trials (epidemiology), Epidemiologic studies, Childhood nutrition, Child health, Infant health, Infant nutrition (including breastfeeding), Neonatal health Source Type: research

Blood group typing in five Afghan populations in the North Hindu‐Kush region: implications for blood transfusion practice
ConclusionThese findings expand the current knowledge about key antigen frequencies. Regarding occurrence of viral markers, further blood transfusion in the region requires rigorous typing. (Source: Transfusion Medicine)
Source: Transfusion Medicine - April 11, 2013 Category: Hematology Authors: S. Mazières, S. A. Temory, H. Vasseur, P. Gallian, J. Di Cristofaro, J. Chiaroni Tags: ORIGINAL ARTICLE Source Type: research

Risk factors for superficial wound complications in hip and knee arthroplasty
Abstract Superficial wound complications have been consistently implicated in the development of prosthetic joint infection. This cohort study aimed to determine perioperative risk factors associated with superficial wound complications. The study was performed over an 18‐month period (January 2011 to June 2012) and included 964 patients undergoing prosthetic hip or knee replacement surgery. The factors associated with superficial wound complication differed according to arthroplasty site. In the combined cohort the following factors were associated with superficial wound complications: the use of 0.5% chlorhexidine in 7...
Source: Clinical Microbiology and Infection - April 10, 2013 Category: Microbiology Authors: K. Carroll, M. Dowsey, P. Choong, T. Peel Tags: Original Article Source Type: research

Gene Underlies Vel Blood Group And Influences Red Blood Cell Traits, Will Lead To Safer Blood Transfusions
Researchers have uncovered the gene at the root of a human blood group that has remained a mystery for the past 60 years. They showed that a genetic deletion on this gene is responsible for the lack of this blood group in some people. With the discovery of the gene behind the Vel blood group, medical scientists can now develop a more reliable DNA test to identify people who lack this group. This will reduce the risk of severe, and sometimes life threatening, destruction of the Vel-positive donor red blood cells in patients with antibodies against Vel... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 9, 2013 Category: Consumer Health News Tags: Blood / Hematology Source Type: news

Improved early postoperative outcome for extracardiac Fontan operation without cardiopulmonary bypass: a single-centre experience [CONGENITAL]
CONCLUSIONS The ECFO without CPB is an established low-risk surgical procedure that improves the early postoperative course and significantly reduces the use of blood products and the duration of pleural effusions in selected patients. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - April 8, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Ovroutski, S., Sohn, C., Miera, O., Peters, B., Alexi-Meskishvili, V., Hetzer, R., Berger, F., Hubler, M. Tags: CONGENITAL Source Type: research

Hydroxyethyl starch 6%, 130/0.4 vs. a balanced crystalloid solution in cardiopulmonary bypass priming: a randomized, prospective study
Conclusions: 6% hydroxyethyl starch 130/0.4 when used as a prime solution did not adversely affect postoperative outcomes including renal functions and postoperative blood transfusion following coronary bypass surgery. (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - April 8, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Hasan Alper GurbuzAhmet Baris DurukanNevriye SalmanMurat TavlasogluElif DurukanHalil ¿brahim UcarCem Yorgancioglu Source Type: research

Adverse maternal outcomes associated with fetal macrosomia: what are the risk factors beyond birthweight?
Conclusion: In women delivering infants with a birthweight of 4000 g or greater, some maternal characteristics as well as labor parameters may worsen maternal outcome beyond the influence of increased fetal weight. (Source: BMC Pregnancy and Childbirth - Latest articles)
Source: BMC Pregnancy and Childbirth - Latest articles - April 8, 2013 Category: OBGYN Authors: Florent FuchsJean BouyerPatrick RozenbergMarie-Victoire Senat Source Type: research

Final chapter to 60-year-old blood group mystery
In this study, published in Nature Genetics online 7 April, they identified the gene that underlies the Vel blood group and will lead to the development of more reliable blood tests and reduce the risk for transfusion patients who lack this blood group. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 7, 2013 Category: Global & Universal Source Type: news

A Martian Stranded on Earth: Alexander Bogdanov, Blood Transfusions, and Proletarian Science
(Source: Journal of the History of Medicine and Allied Sciences)
Source: Journal of the History of Medicine and Allied Sciences - April 4, 2013 Category: History of Medicine Authors: Rogers, J. Tags: Book Reviews Source Type: research

Mesohepatectomy with total caudate lobectomy of the liver for hepatocellular carcinoma
Conclusion: Although mesohepatectomy with total caudate lobectomy of the liver is technically more difficult than mesohepatectomy of the liver because the caudate lobe must be completely detached from the inferior vena cava and the hilar plate, it is a safe and effective treatment method in selected patients with hepatocellular carcinoma located at both the central bisections and the paracaval portion of the caudate lobe. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - April 4, 2013 Category: Cancer & Oncology Authors: Hiromichi IshiiShinpei OginoKoki IkemotoAtsushi TomaKenji NakamuraTsuyoshi ItohToshiya Ochiai Source Type: research

The impact of tubal ectopic pregnancy in Papua New Guinea - a retrospective case review
Conclusions: Tubal EP is a common gynaecological emergency in a referral hospital in coastal PNG, and causes significant morbidity, in particular amongst women residing in rural areas. Sexually transmitted infections are likely to represent the most important risk factor for tubal EP in PNG. Interventions to reduce the morbidity due to tubal EP include the prevention, detection and treatment of sexually transmitted infections, identification and reduction of barriers to prompt presentation, increasing health workers' awareness of ectopic pregnancy, providing pregnancy test kits to rural health centres, and strengthening ho...
Source: BMC Pregnancy and Childbirth - Latest articles - April 4, 2013 Category: OBGYN Authors: Nancy HamuraJohn BolngaRegina WangnapiAndrew HorneStephen RogersonHolger Unger Source Type: research

Hepatitis Safeguards Needed For HIV Sufferers
Stronger protections are needed to prevent people with HIV from also becoming infected with hepatitis, researchers argue in a new study led by Michigan State University. Behaviors that put people at higher risk of contracting HIV - sharing needles, having unprotected sex or getting blood transfusions, for instance - also raise their risk of getting hepatitis B or C, diseases that attack the liver and, if untreated, can be deadly. The study, which included all registered cases of HIV in Michigan, found about four percent of HIV-positive people also had hepatitis... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 1, 2013 Category: Consumer Health News Tags: HIV / AIDS Source Type: news