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Pediatric cardiac surgery: Effect of a miniaturized bypass circuit in reducing homologous blood transfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: I read with great interest the excellent article by Koster and colleagues. We have recently published our experience in treating 150 pediatric patients with a 120-mL prime volume miniaturized bypass circuit, vacuum-assisted venous drainage, and intermittent warm blood microplegia. Our results, although less impressive than those of Koster and colleagues, confirmed the efficiency of a small prime volume for reduction of allogeneic blood transfusion. With a nadir hemoglobin value of 8 g/dL during cardiopulmonary bypass, we demonstrated the good tolerance of hemodilution using 2 markers: preoperative and posto...
Source: The Journal of Thoracic and Cardiovascular Surgery - November 20, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Yves Dominique Durandy Tags: Letters to the Editor Source Type: journals

West Nile Virus Transmission via Organ Transplantation and Blood Transfusion --- Louisiana, 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - November 20, 2009 Category: American Health Source Type: organizations

Islet Cell Transplantation In ScotlandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Scottish National Blood Transfusion Service has opened a new laboratory in Edinburgh to offer around 12 people a year islet cell transplant therapy. Islet cell transplant therapy is a pioneering treatment for diabetes that was part-funded by Diabetes UK in its research stages. About islets Islets are groups of cells in the pancreas that contain the insulin-producing beta cells. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Diabetes Source Type: news

Islet Cell Transplantation In ScotlandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Scottish National Blood Transfusion Service has opened a new laboratory in Edinburgh to offer around 12 people a year islet cell transplant therapy. Islet cell transplant therapy is a pioneering treatment for diabetes that was part-funded by Diabetes UK in its research stages. About islets Islets are groups of cells in the pancreas that contain the insulin-producing beta cells. (Source: Diabetes News From Medical News Today)
Source: Diabetes News From Medical News Today - November 20, 2009 Category: Endocrinology Tags: Diabetes Source Type: news

Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic blood transfusion is increasingly indicated in patients with sickle cell disease. Measuring resulting iron overload remains a challenge. Children without viral hepatitis enrolled in 2 trials for stroke prevention were examined for iron overload (STOP and STOP2; n = 271). Most received desferrioxamine chelation. Serum ferritin (SF) changes appeared nonlinear compared with prechelation estimated transfusion iron load (TIL) or with liver iron concentrations (LICs). Averaged correlation coefficient between SF and TIL (patients/observations, 26 of 164) was r = 0.70; between SF and LIC (patients/observations, 33 of 47) w...
Source: Blood - November 19, 2009 Category: Hematology Authors: Adamkiewicz, T. V., Abboud, M. R., Paley, C., Olivieri, N., Kirby-Allen, M., Vichinsky, E., Casella, J. F., Alvarez, O. A., Barredo, J. C., Lee, M. T., Iyer, R. V., Kutlar, A., McKie, K. M., McKie, V., Odo, N., Gee, B., Kwiatkowski, J. L., Woods, G. M., C Tags: Free Research Articles, Red Cells, Iron, and Erythropoiesis, Clinical Trials and Observations Source Type: journals

Use of Solid and Cancellous Autologous Bone Graft for Fractures and NonunionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article describes the use of solid and cancellous bone graft in the treatment of acute bone loss and nonunion. (Source: Orthopedic Clinics of North America)
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: James T. Marino, Bruce H. Ziran Source Type: journals

A woman with acute myelopathy in pregnancy: case progressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 19, 2009 Category: Journals (General) Authors: Reuss, R., Rommer, P. S, Bruck, W., Paul, F., Bolz, M., Jarius, S., Boettcher, T., Grossmann, A., Bock, A., Zipp, F., Benecke, R., Zettl, U. K Tags: Infectious diseases, Urology, Journalology, Haematology (incl blood transfusion), Immunology (including allergy), Multiple sclerosis, Spinal cord, Pregnancy, Reproductive medicine, Radiology, Clinical diagnostic tests, Urological surgery PRACTICE Source Type: journals

Dengue virus during blood donation: Pre-screen using NS1 antigenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Estimates for dengue transmission during blood donations have been upsetting in diverse geographical locations. During the 2004 dengue virus (DENV) outbreak in Cairns, Australia, the risk of collecting a viremic donation could have been as high as 1 in 1028 during the peak of the outbreak . Using a mathematical model and assuming a ratio of asymptomatic to symptomatic infections of 2:1–10:1, the risk for dengue-infected blood transfusions in Singapore, a city-state in Asia, during 2005 was estimated to be 1625–6/10,000 blood transfusions . In a tertiary care teaching hospital that provides care in Northeast Mexico, 800...
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Subhash C. Arya, Nirmala Agarwal Tags: Letter to the Editor Source Type: journals

Blood transfusion therapy for 41 earthquake casualtiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Blood transfusion was an effective therapy for the earthquake casualties. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Zhongjun Li, Weidong Wang, Te Chen Tags: Submitted Papers Source Type: journals

Postop Anemia in High-CV-Risk Patients: No CV Gains From Fixed Hemoglobin Target in TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A randomized trial found no protection from in-hospital cardiovascular events with a strategy of blood transfusions to maintain hemoglobin above 10 g/dL, compared with a more conservative approach to transfusion therapy, in patients with CV disease or risk factors who underwent hip surgery. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 18, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

Dose reduction of epoetin-alpha in the prevention of chemotherapy-induced anaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  Dose reduction was as effective as fixed doses in anaemia prophylaxis but reduced the amount of prescribed epoetin substantially. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00520-009-0773-5Authors François Lüthi, University Hospital–CHUV BH06 Centre Pluridisciplinaire d’Oncologie Rue du Bugnon 46 1011 Lausanne SwitzerlandMiklos Pless, University of Basel Department of Oncology Basel SwitzerlandSerge Leyvraz, University Hospital–CHUV BH06 Centre Pluridisciplinaire d’Oncologie Rue du Bugnon 46 1011 Lausanne SwitzerlandBeat Biedermann, University of Basel Departm...
Source: Supportive Care in Cancer - November 17, 2009 Category: Cancer & Oncology Tags: Supportive Care in Cancer Source Type: journals

Miracle baby survives 11 blood transfusions INSIDE the wombEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Doctors performed multiple blood transfusions on baby Jasmine, after they discovered her blood type was incompatible with that of her mother Melanie. (Source: the Mail online | Health)
Source: the Mail online | Health - November 17, 2009 Category: Consumer Health News Source Type: news

Postop anemia in high-CV-risk patients: No CV gains from fixed hemoglobin target in trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A randomized trial found no protection from in-hospital cardiovascular events with a strategy of blood transfusions to maintain hemoglobin above 10 g/dL, compared with a more conservative approach to transfusion therapy, in patients with CV disease or risk factors who underwent hip surgery. (Source: theHeart.org)
Source: theHeart.org - November 16, 2009 Category: Cardiology Source Type: info

Percutaneous nephrolithotomy in horseshoe Kidneys: is rigid nephroscopy sufficient tool for complete clearance? a case series studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Percutaneous nephrolithotomy is generally safe and successful in the management of stones in horseshoe kidneys. However, location of the stones in these patients is crucial to decide the proper tool for optimal stone clearance result. (Source: BioMed Central)
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Mohamed El GhoneimyAhmed KoderaAshraf EmranTamer OrbanAhmed ShabanMohamed El Gammal Source Type: journals

Drugs to Lower Anemia Risk Linked to Pulmonary EmbolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of erythropoiesis-stimulating agents to reduce anemia risk has rapidly increased since their approval to nearly half of advanced cancer patients undergoing chemotherapy, but they are associated with a higher risk of deep vein thrombosis and pulmonary embolism while having no effect on the rate of blood transfusion, according to a study published online Nov. 10 in the Journal of the National Cancer Institute. (Source: Modern Medicine)
Source: Modern Medicine - November 16, 2009 Category: Journals (General) Source Type: info

Do Blood Transfusions Affect the INR?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Whether or not the international normalized ratio (INR) will be "preserved" depends on the type of blood transfusion given. Medscape Pharmacists (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 13, 2009 Category: Consumer Health News Tags: Pharmacist Source Type: news

Epidural anesthesia and cancer recurrence rates after radical prostatectomy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: No difference was observed between the epidural and control groups in disease-free survival at a median follow-up time of 4.5 years. There is a need for large randomized controlled trials to determine the ability of epidural analgesia to alter disease recurrence rates following radical prostatectomy. PMID: 19911247 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - November 13, 2009 Category: Anesthesiology Authors: Tsui BC, Rashiq S, Schopflocher D, Murtha A, Broemling S, Pillay J, Finucane BT Tags: Can J Anaesth Source Type: journals

Direct assessment of cytomegalovirus transfusion-transmitted risks after universal leukoreduction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Among all 46 baseline seronegative recipients and 1316 evaluable transfusions, the calculated overall CMV-TTD risk was up to 6.5% (95% confidence interval [CI], 1.0%-18.0%) in terms of TRs and up to 0.23% (95% CI, 0.06%-0.62%) in terms of non-CMV-screened leukoreduced cellular products. In summary, after universal leukoreduction, CMV-TTD, while uncommon, may still occur. PMID: 19912585 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 13, 2009 Category: Hematology Authors: Wu Y, Zou S, Cable R, Dorsey K, Tang Y, Hapip CA, Melmed R, Trouern-Trend J, Wang JH, Champion M, Fang C, Dodd R Tags: Transfusion Source Type: journals

Declining hepatitis C virus (HCV) prevalence in pregnant women: impact of anti-HCV screening of donated blood.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Anti-HCV screening of donated blood and hygienic improvements have markedly decreased HCV infection of pregnant women with a transfusion history; however, 70% of anti-HCV-reactive women were deemed to be infected via routes other than transfusion. PMID: 19912584 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 13, 2009 Category: Hematology Authors: Ohto H, Ishii T, Kitazawa J, Sugiyama S, Ujiie N, Fujimori K, Ariga H, Satoh T, Nollet KE, Okamoto H, Hoshi T Tags: Transfusion Source Type: journals

The quality of stored umbilical cord and adult-donated whole blood in Mombasa, Kenya.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Variable volumes of UC-WB can be stored for 35 days without prestorage processing and further work into its suitability for transfusion to children is justified. The quality of conventional AD-WB is a concern and needs further evaluation. PMID: 19912583 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 13, 2009 Category: Hematology Authors: Hassall O, Maitland K, Fegan G, Thitiri J, Pole L, Mwakesi R, Denje D, Wambua K, Mandaliya K, Bates I Tags: Transfusion Source Type: journals

Gyrus PlasmaKinetic bipolar coagulation device for liver resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The Gyrus PlasmaKinetic coagulation device is a novel instrument for hepatic parenchymal transection in liver resection, which can be safely used in cirrhotic and non-cirrhotic patients. (Source: ANZ Journal of Surgery)
Source: ANZ Journal of Surgery - November 12, 2009 Category: Surgery Authors: Jeremy Tan, Andrew Hunt, Ruwan Wijesuriya, Luc Delriviere, Andrew Mitchell Source Type: journals

Blood transfusion linked to STEMI mortality, causality remains uncertainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Red blood cell transfusion is associated with increased mortality in patients with ST-segment elevation myocardial infarction, researchers report. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - November 12, 2009 Category: Cardiology Source Type: news

Blood transfusions after thoracoscopic anterior thoracolumbar vertebrectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Thoracoscopic AVBR with expandable cages can be accomplished safely with acceptable operative times and blood loss and low transfusion rates. Content Type Journal ArticleCategory Clinical ArticleDOI 10.1007/s00701-009-0549-1Authors Brian T. Ragel, University of Utah Department of Neurosurgery Salt Lake City UT USAPeter Kan, University of Utah Department of Neurosurgery Salt Lake City UT USAMeic H. Schmidt, University of Utah Department of Neurosurgery Salt Lake City UT USA Journal Acta NeurochirurgicaOnline ISSN 0942-0940Print ISSN 0001-6268 (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - November 11, 2009 Category: Neurology Tags: Acta Neurochirurgica Source Type: journals

Postoperative Morbidity and Mortality of Head and Neck Cancers in Patients With Liver Cirrhosis Undergoing Surgical Resection Followed by Microsurgical Free Tissue TransferEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions  Child’s class, along with its several components, and intraoperative blood transfusion of ≥2 units are predictive factors for morbidity and mortality. Content Type Journal ArticleCategory Reconstructive OncologyDOI 10.1245/s10434-009-0805-xAuthors Huang-Kai Kao, Chang Gung Memorial Hospital and Chang Gung University Department of Plastic and Reconstructive Surgery Tao-Yuan TaiwanKai-Ping Chang, Chang Gung Memorial Hospital, Chang Gung University Department of Otolaryngology-Head and Neck Surgery Tao-Yuan TaiwanWei-Cheng Ching, Chang Gung Memorial Hospital and Chang Gung University Depar...
Source: Annals of Surgical Oncology - November 11, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

One year period prevalence of blood transfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transfusion practice is reported to differ considerably between countries. Comparisons often rely on transfusion rates, incidence - or prevalence rates. In this paper, the one-year period prevalence rate (1-YPPR) of transfusion of red cells (RBC) is presented. Transfusion data, demographic data and patient data were retrospectively combined to calculate sex and diagnosis specific and age standardized 1-YPPR s of RBC transfusion for the complete population in a Danish county. During the calendar year of 2006, 4427 patients received RBC transfusion in Funen County. The crude 1-YPPR of RBC transfusion was 9.2/1000 citizens. M...
Source: Transfusion Medicine - November 11, 2009 Category: Hematology Authors: J. T. Madsen, M. L. Kimper-Karl, U. Sprogøe, J. Georgsen, K. Titlestad Source Type: journals

Erythropoiesis-stimulating agents: concern over patterns of use in the US and risksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: J Nat Cancer Inst Area: News According to research published early online in the Journal of the National Cancer Institute, use of erythropoiesis-stimulating agents in US cancer patients undergoing chemotherapy has increased 10-fold since their introduction, yet there has been no associated decline in the rate of blood transfusions.   Researchers sought to evaluate the impact of erythropoiesis-stimulating agents on the blood transfusion rate, long-term risk of venous thromboembolism, and overall survival in patients who were aged 65 years or older, who had a pathologically confirmed primary diagnosis of di...
Source: NeLM - Renal medicine - November 11, 2009 Category: Urology & Nephrology Source Type: organizations

No Reduction in Transfusions with ESAs (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Widespread use of erythropoiesis-stimulating agents among cancer patients undergoing chemotherapy has not resulted in the expected decrease in the rate of blood transfusions, a large retrospective cohort study found. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - November 10, 2009 Category: Hematology Source Type: news

Surgical Management of Infrahilar/Suprapancreatic Cholangiocarcinoma: an Analysis of the Surgical Procedures, Surgical Margins, and Survivals of 77 PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  Perineural invasion, rather than the type of surgical procedure, had a significant impact on surgical curability and survival of patients with infrahilar/suprapancreatic cholangiocarcinoma treated according to our intention-to-treat strategy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11605-009-1072-7Authors Yoshihiro Sakamoto, National Cancer Center Hospital Hepatobiliary and Pancreatic Surgery Division 5-1-1 Tsukiji Chuo-ku Tokyo 104-0045 JapanKazuaki Shimada, National Cancer Center Hospital Hepatobiliary and Pancreatic Surgery Division 5-1-1 Tsukiji Chuo-ku Tokyo 10...
Source: Journal of Gastrointestinal Surgery - November 10, 2009 Category: Surgery Tags: Journal of Gastrointestinal Surgery Source Type: journals

New Swine Flu Victim: Blood SupplyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The swine-flu pandemic is creating unexpected problems for the nation's blood supply—keeping some donors away and raising questions whether the flu can be spread through a blood transfusion. (Source: WSJ.com: Health)
Source: WSJ.com: Health - November 10, 2009 Category: Pharmaceuticals Tags: FREE Source Type: news

Pregnancy and {beta}-thalassemia: an Italian multicenter experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Provided that a multidisciplinary team is available, pregnancy is possible, safe and usually has a favorable outcome in patients with thalassemia. In women with hypogonadotropic hypogonadism, gonadal function is usually intact and fertility is usually retrievable. PMID: 19903676 [PubMed - as supplied by publisher] (Source: Haematologica)
Source: Haematologica - November 10, 2009 Category: Hematology Authors: Origa R, Piga A, Quarta G, Forni GL, Longo F, Melpignano A, Galanello R Tags: Haematologica Source Type: journals

New Swine Flu Victim: Blood SupplyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The swine-flu pandemic is creating unexpected problems for the nation's blood supply—keeping some donors away and raising questions whether the flu can be spread through a blood transfusion. (Source: WSJ.com: Health)
Source: WSJ.com: Health - November 9, 2009 Category: Pharmaceuticals Tags: FREE Source Type: news

Detecting autologous blood transfusions: a comparison of three passport approaches and four blood markersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Blood passport has been suggested as an indirect tool to detect various kinds of blood manipulations. Autologous blood transfusions are currently undetectable, and the objective of this study was to examine the sensitivities of different blood markers and blood passport approaches in order to determine the best approach to detect autologous blood transfusions. Twenty-nine subjects were transfused with either one (n=8) or three (n=21) bags of autologous blood. Hemoglobin concentration ([Hb]), percentage of reticulocytes (%ret) and hemoglobin mass (Hbmass) were measured 1 day before reinfusion and six times after reinfusion....
Source: Scandinavian Journal of Medicine and Science in Sports - November 9, 2009 Category: Sports Medicine Authors: J. Mørkeberg, K. Sharpe, B. Belhage, R. Damsgaard, W. Schmidt, N. Prommer, C. J. Gore, M. J. Ashenden Source Type: journals

Improvement of an ultrasensitive human immunodeficiency virus Type 1 real-time reverse transcriptase-polymerase chain reaction targeting the long terminal repeat region.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Surveillance of HIV-1 genetic diversity is essentially required to continually evaluate its impact on performance of diagnostic and patient monitoring assays. PMID: 19906037 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 9, 2009 Category: Hematology Authors: Edelmann A, Kalus U, Oltmann A, Stein A, Unbehaun A, Drosten C, Krüger DH, Hofmann J Tags: Transfusion Source Type: journals

Storage of murine red blood cells enhances alloantibody responses to an erythroid-specific model antigen.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These findings demonstrate that HOD murine RBCs become more immunogenic with storage and generate the rationale for clinical trials to test if the same phenomenon is observed in humans. Length of storage of RBCs may represent a previously unappreciated variable in whether or not a transfusion recipient becomes alloimmunized. PMID: 19906034 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 9, 2009 Category: Hematology Authors: Hendrickson JE, Hod EA, Spitalnik SL, Hillyer CD, Zimring JC Tags: Transfusion Source Type: journals

Risk factors for indications of intraoperative blood transfusion among patients undergoing surgical treatment for colorectal adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONTEXT: Identification of risk factors for requiring transfusions during surgery for colorectal cancer may lead to preventive actions or alternative measures, towards decreasing the use of blood components in these procedures, and also rationalization of resources use in hemotherapy services. This was a retrospective case-control study using data from 383 patients who were treated surgically for colorectal adenocarcinoma at "Fundação Pio XII", in Barretos-SP, Brazil, between 1999 and 2003. OBJECTIVE: To recognize significant risk factors for requiring intraoperative blood transfusion in colorectal cancer surgical proced...
Source: Arquivos de Gastroenterologia - November 6, 2009 Category: Gastroenterology Source Type: journals

Comparison between hepatitis B and C epidemiological profiles at a public institution in São Paulo, BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONTEXTO: As hepatites virais constituem doença de notificação compulsória e apresentam grande importância em nosso meio devido à elevada prevalência. OBJETIVO: Comparar o perfil epidemiológico dos casos confirmados de hepatites B e C notificados no Núcleo de Vigilância Epidemiológica do Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, no período entre janeiro de 2004 e abril de 2007. MATERIAL: Os resultados foram analisados através do teste do qui ao quadrado. RESULTADOS: Observou-se 112 casos confirmados de hepatite B e 651 de hepatite C. Houve predominância do sexo masculino dentre os ...
Source: Arquivos de Gastroenterologia - November 6, 2009 Category: Gastroenterology Source Type: journals

Affymax And Takeda Announce Hematide™ Publication In The New England Journal Of MedicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Affymax, Inc. (Nasdaq:AFFY) and Takeda Pharmaceutical Global Research & Development Center, Inc., announced data from a Phase 2 clinical trial of Hematide™ showing that Hematide increased hemoglobin and reduced or eliminated the need for blood transfusion in most patients with erythropoietin-induced pure red cell aplasia (PRCA). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 5, 2009 Category: Consumer Health News Tags: Blood / Hematology Source Type: news

"X marks the spot" is not a pleural guaranteeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Postgraduate Medical Journal)
Source: Postgraduate Medical Journal - November 5, 2009 Category: Journals (General) Authors: Medford, A R L, Entwisle, J J Tags: Journalology, Haematology (incl blood transfusion), Drugs: cardiovascular system, Radiology, Clinical diagnostic tests, Radiology (diagnostics), Ethics Images in medicine Source Type: journals

[Autoimmune hemolytic anemia.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background. Knowledge of autoimmune hemolytic anemia is rapidly increasing, especially on pathogenesis, associated disorders and aspects of transfusion immunology. New treatment options have emerged. Material and method. This review is based on selected publications, a non-systematic search in PubMed and the authors' own research. Results. Autoimmune hemolytic anemia is a heterogeneous group of diseases. The warm-antibody type is frequently associated with chronic lymphocytic leukemia or autoimmune systemic disease. Corticosteroids are still the first-line therapy and splenectomy is second-line, while rituximab has bec...
Source: Tidsskrift for den Norske Laegeforening - November 5, 2009 Category: Journals (General) Authors: Berentsen S, Sundic T, Hervig T, Tjønnfjord GE Tags: Tidsskr Nor Laegeforen Source Type: journals

Efficacy of TachoSil patches in controlling Dacron suture-hole bleeding after abdominal aortic aneurysm open repairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose.The aim of this study is evaluate the efficacy of TachoSil patches in controlling suture-hole bleeding after elective infrarenal abdominal aortic aneurysm (AAA) replacement with Dacron graft.Materials and Methods.Patients undergoing elective replacement of infrarenal AAA with Dacron grafts were prospectively randomized to TachoSil patches (Group I) or standard compression with surgical swabs (Group II). We evaluated time to haemostasis, blood loss during the operation, blood loss after cross-clamp removal, duration of operation, drain volume, requirement for blood transfusion and surgeons rating of efficacy. Result...
Source: BioMed Central - November 4, 2009 Category: Journals (General) Authors: Guido BajardiFelice PecoraroDomenico Mirabella Source Type: journals

Drug May Boost Hemoglobin in Chronic Kidney DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with chronic kidney disease and a deficit in red blood cells resulting from anti-erythropoietin antibodies were able to stop supportive blood transfusions following injections of an erythropoietin-receptor agonist in a British study reported in the Nov. 5 New England Journal of Medicine. (Source: Modern Medicine)
Source: Modern Medicine - November 4, 2009 Category: Journals (General) Source Type: info

[Situation and perspectives of blood transfusion in Togo.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the successive stages of the reorganization of the blood transfusion sector in Togo. The starting point was the elaboration of the national policy of blood transfusion, then the adoption of a decree organizing the sector as well the various decree of application, particularly that related to transfusion good practices. The current policy recommends two poles of qualification of the blood ant its components and the creation of six stations of collection and distribution attached to these poles. The reorganization started with the rehabilitation of the National Blood Transfusion Centre (CNTS) in Lomé. If the p...
Source: Transfusion Clinique et Biologique - November 4, 2009 Category: Hematology Authors: Ségbéna AY, Fétéké L, Bikandou B, Awitala EJ, Koura AG Tags: Transfus Clin Biol Source Type: journals

Iron Infusions Do Not Cut Blood Transfusions With Colorectal Cancer SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intravenous infusions of iron sucrose before planned colorectal cancer surgery do not reduce perioperative blood transfusions, according to a report in the British Journal of Surgery for October 9. Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - November 3, 2009 Category: Surgery Tags: General Surgery Source Type: info

Iron therapy in chronic kidney disease: current controversiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anaemia in chronic kidney disease (CKD) is a complex disease that requires an integrated approach to incorporate both diagnostic and therapeutic interventions and to address the different facets of its aetiology and pathophysiology. The advent of erythropoiesis stimulating agents (ESA) has revolutionised the therapy of anaemia of CKD, and has resulted in a significant decline in the need for blood transfusions in CKD patients. The routine application of ESA has also led to the need for concomitant iron supplementation. ESA and iron therapy now form the cornerstone of anaemia management in CKD. Intravenous iron administrati...
Source: Journal of Renal Care - November 3, 2009 Category: Urology & Nephrology Authors: Csaba P Kovesdy, Kamyar Kalantar-Zadeh Tags: ARTICLES Source Type: journals

Frequency of Positive XmnI(G)gamma polymorphism and coinheritance of common alpha thalassemia mutations do not show statistically significant difference between thalassemia major and intermedia cases with homozygous IVSII-1 mutation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
From 362 thalassemia cases referred to adult thalassemia clinic of the Iranian blood transfusion organization (IBTO) for genotyping, 103 cases (28.5%) had a common primary disease factor, IVSII-1 mutation in homozygous state. 61 (59.2%) of these individuals represented thalassemia major and 42 (40.8%) thalassemia intermedia clinical phenotype. To re-evaluate our current diagnostic criteria, XmnI(G)gamma polymorphism and coexistence of alpha thalassemia mutations, frequently recalled as important factors modifying the clinical phenotype of homozygous beta zero thalassemia cases in our country, were examined in both grou...
Source: Blood Cells, Molecules & Diseases - November 3, 2009 Category: Hematology Authors: Neishabury M, Azarkeivan A, Najmabadi H Tags: Blood Cells Mol Dis Source Type: journals

Inhibitory role of cAMP on doxorubicin-induced apoptosis in pre-B ALL cells through dephosphorylation of p53 serine residuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our results suggest that activation of cAMP-signaling system may repress p53-dependent apoptosis in malignant cells exposed to doxorubicin. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10495-009-0417-8Authors Majid Safa, Iran University of Medical Sciences Department of Hematology, Faculty of Allied Medicine P.O. Box # 14155-6183 Tehran IranAhmad Kazemi, Iran University of Medical Sciences Department of Hematology, Faculty of Allied Medicine P.O. Box # 14155-6183 Tehran IranHamid Zand, Shahid Beheshti University M. C. Department of Basic Medical Sciences, National Nutrition and Food ...
Source: Apoptosis - November 2, 2009 Category: Molecular Biology Tags: Apoptosis Source Type: journals

Hemispherectomy-associated complications from the Kids’ Inpatient DatabaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In-hospital mortality of HS is low, and blood transfusion was performed in over one third of patients. There appear to be several risk factors that can predict the likelihood of transfusion and may warrant close observation before hemispherectomy. (Source: Epilepsy Research)
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Mohamad Z. Koubeissi, Tanvir U. Syed, Ishtiaq Syed, James Jordan, Amer Alshekhlee, Eric H. Kossoff Tags: Research Papers Source Type: journals

Cellular prion protein in blood platelets associates with both lipid rafts and the cytoskeleton.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The recently shown transmissibility of variant Creutzfeldt-Jakob disease (vCJD) by blood transfusion emphasises the need for better understanding of the cellular prion protein (PrPc) in blood. A substantial amount of cell-associated PrPc in blood resides in platelets. Platelet activation leads to up-regulation of PrPc on the platelet surface and its release on exosomes and microparticles. The sub-cellular localisation and function of platelet PrPc, however, is poorly understood. In the present study, we investigated the association of PrPc with platelet lipid rafts and the platelet cytoskeleton. Immuno-fluorescence mic...
Source: Thrombosis and Haemostasis - November 1, 2009 Category: Hematology Authors: Brouckova A, Holada K Tags: Thromb Haemost Source Type: journals

Hepatitis C seroprevalence and associated risk factors, Anyang, China.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatitis C virus screening was conducted among 8,226 residents 25-65 years of age in 4 counties of China; virus prevalence was 0.9%. A subsequent case-control study indicated blood transfusion (odds ratio [OR] 4.55), esophageal balloon examination (OR 3.78), and intravenous injection (OR 5.83) were associated with infection. PMID: 19891874 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - November 1, 2009 Category: Infectious Diseases Authors: Liu F, Chen K, He Z, Ning T, Pan Y, Cai H, Ke Y Tags: Emerg Infect Dis Source Type: journals

Anti-HLA Antibody Profile of Turkish Patients With End-Stage Renal DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Exposure to human leukocyte antigens (HLA) via blood transfusions, pregnancies, and previous transplantations can result in anti-HLA antibody production. The presence of anti-HLA antibodies in recipient sera before transplantation is an important risk factor. To demonstrate the anti-HLA antibody status of Turkish end-stage renal disease (ESRD) patients, 674 patients (mean age, 40.35 ± 13.15 years; female/male, 328/346) were enrolled into the study. Anti-HLA antibody screening and identification tests were performed using an enzyme-linked immunosorbent assay (ELISA) method. The panel-reactive antibody (PRA)-negat...
Source: Transplantation Proceedings - November 1, 2009 Category: Transplant Surgery Authors: G.E. Karahan, Y. Seyhun, F. Oguz, C. Kekik, E. Onal, Y. Caliskan, H. Bakkaloglu, H. Yazici, A. Turkmen, A.E. Aydin, M.S. Sever, U. Eldegez, M.N. Carin Tags: Renal Transplantation Source Type: journals