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What Is Bone Cancer (Sarcoma)? What Causes Bone Cancer?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bone cancer is an uncommon cancer that begins in a bone. It can originate in any bone in the body, but the long bones that make up the arms and legs are most commonly affected. Several types of bone cancer exist. Some types of bone cancer occur primarily in children, while others affect mostly adults. Primary bone cancer is cancer that starts in the bone. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

What Is Bone Cancer (Sarcoma)? What Causes Bone Cancer?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bone cancer is an uncommon cancer that begins in a bone. It can originate in any bone in the body, but the long bones that make up the arms and legs are most commonly affected. Several types of bone cancer exist. Some types of bone cancer occur primarily in children, while others affect mostly adults. Primary bone cancer is cancer that starts in the bone. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 19, 2009 Category: Cancer & Oncology Tags: Cancer / Oncology Source Type: news

Fas expression in metastatic osteosarcoma cells is not regulated by CpG island methylation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our data indicate that decreased Fas expression in OS cells is not secondary to DNA methylation of CpG islands in the Fas gene and that Fas expression cannot be increased by using demethylation agents. PMID: 19911702 [PubMed - in process] (Source: Oncology Research)
Source: Oncology Research - November 18, 2009 Category: Cancer & Oncology Authors: Huang G, Koshkina NV, Kleinerman ES Tags: Oncol Res Source Type: journals

The value of local treatment in patients with primary, disseminated, multifocal Ewing sarcoma (PDMES)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
was investigated.We analyzed 120 patients registered into the European Ewing Tumor Working Initiative of National Groups (EURO-E.W.I.N.G. 99) trial at the trial center of Muenster from 1998 to 2006. Median age was 16.2 years. Local treatment of the primary tumor was surgery in 26 of 120 patients, surgery and radiotherapy in 21 patients, and definitive radiotherapy in 40 patients. For treatment of metastases, 6 of 120 patients received surgery; 9 patients, surgery and radiotherapy; and 33 patients, definitive radiotherapy. Forty-seven (39%) patients had local treatment of both the primary tumor and metastases, 41 (34%) pat...
Source: Cancer - November 18, 2009 Category: Cancer & Oncology Authors: Julia Haeusler, Andreas Ranft, Tobias Boelling, Georg Gosheger, Gabriele Braun-Munzinger, Volker Vieth, Stefan Burdach, Henk van den Berg, Heribert Juergens, Uta Dirksen Source Type: journals

Differential Presentations, Clinical Courses, and Survivals of Osteosarcomas of the Proximal Humerus over Other Extremity LocationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The association between proximal humeral osteosarcoma and poor survival could be the result of unresponsiveness to chemotherapy, which was expressed by a tumor volume increase in our patients. Content Type Journal ArticleCategory Bone and Soft Tissue SarcomasDOI 10.1245/s10434-009-0825-6Authors Wan Hyeong Cho, Korea Cancer Center Hospital Departments of Orthopedic Surgery Seoul KoreaWon Seok Song, Korea Cancer Center Hospital Departments of Orthopedic Surgery Seoul KoreaDae-Geun Jeon, Korea Cancer Center Hospital Departments of Orthopedic Surgery Seoul KoreaChang-Bae Kong, Korea Cancer Cent...
Source: Annals of Surgical Oncology - November 17, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment StrategyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. From our data, postirradiation sarcoma should not be managed differently from primary sarcoma. Chemotherapy has to be included in the treatment plan of postirradiation sarcoma, in future studies. (Source: Sarcoma)
Source: Sarcoma - November 17, 2009 Category: Cancer & Oncology Source Type: journals

Gene Expression Profiles Classify Human Osteosarcoma Xenografts According to Sensitivity to Doxorubicin, Cisplatin, and Ifosfamide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The expression profiles contained several novel biomarker candidates that may help predict the responsiveness of osteosarcoma to doxorubicin, cisplatin, and ifosfamide. The potential of selected candidates will be further validated on clinical specimens from osteosarcoma patients. (Clin Cancer Res 2009;15(23):OF1-9). PMID: 19920113 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 17, 2009 Category: Cancer & Oncology Authors: Bruheim S, Xi Y, Ju J, Fodstad O Tags: Clin Cancer Res Source Type: journals

Doxorubicin Loaded Polymeric Nanoparticulate Delivery System to Overcome Drug Resistance in OsteosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Lipid-modified dextran nanoparticles loaded with doxorubicin showed pronounced anti-proliferative effects against osteosarcoma cell lines. These findings may lead to new treatment options for MDR osteosarcoma. (Source: BMC Cancer)
Source: BMC Cancer - November 16, 2009 Category: Cancer & Oncology Authors: Michiro SusaArun IyerKeinosuke RyuFrancis HornicekHenry MankinMansoor AmijiZhenfeng Duan Source Type: journals

Approved Lymphoma Drug Shows Promise In Early Tests Against Bone CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A drug already approved for the treatment of lymphoma may also slow the growth of the most deadly bone cancer in children and teens, according to an early-stage study published online today in the International Journal of Cancer. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 14, 2009 Category: Cancer & Oncology Source Type: news

Rethinking Fluoride?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Have your views on fluoridation changed given new findings about osteosarcoma in dogs and studies linking fluoride to bone cancer in young boys? (Source: Dr. Weil Q&A)
Source: Dr. Weil Q&A - November 13, 2009 Category: Consumer Health Advice Source Type: info

Bicarbonate of Soda Used to Cure Stage Four Prostate CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionThe last quote from Dr. Sircus sums it up. When dealing with any natural cancer cures, it is wise to take a literally holistic approach, one that does not compromise any of the protocols used in the holistic combination. Obviously there will be disagreements among practitioners as to what a root cause is for any disease, especially cancer.So finding one`s course of action can be baffling at first. But considering the low costs with the battery of options in the field of natural medicine, it seems worth investigating until one finds what is right or what combination of protocols is right.We are fortunate that desp...
Source: NaturalNews.com - November 13, 2009 Category: Consumer Health Advice Source Type: news

Titanium surfaces with adherent selenium nanoclusters as a novel anticancer orthopedic material.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this in vitro study was to create a new biomaterial which can both restore bone and prevent cancer growth at the implant-tissue interface. Elemental selenium was chosen as the biologically active agent in this study because of its known chemopreventive and chemotherapeutic properties. It was found that when selenite salts were reduced by glutathione in the presence of an immersed titanium substrate, elemental selenium nucleated and grew into adherent, hemispherical nanoclusters that formed a nanostructured composite surface. Three types of surfaces with different selenium surface densities on titanium were...
Source: Biomed Res - November 13, 2009 Category: Research Authors: Tran PA, Sarin L, Hurt RH, Webster TJ Tags: J Biomed Mater Res A Source Type: journals

Soft tissue sarcomas with complex genomic profilesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed of spindle cell/pleomorphic sarcomas, including leiomyosarcoma, myxofibrosarcoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, malignant peripheral nerve sheath tumor, angiosarcoma, extraskeletal osteosarcoma, and spindle cell/pleomorphic unclassified sarcoma (previously called spindle cell/pleomorphic malignant fibrous histiocytoma). These neoplasms show, characteristically, gains and losses of numerous chromosomes or chromosome regions, as well as amplifications. Many of them share recurr...
Source: Virchows Archiv - November 12, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Expression and its clinical significance of heat shock protein gp96 in human osteosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the study was to observe the expression of heat shock protein gp96 (HSPgp96) and explore its clinical significance in human osteosarcoma. <br />The expression of HSPgp96 was studied in 44 osteosarcoma tissues including 24 osteoblastic sarcoma and 20 chondroblastic sarcoma, normal tissues adjacent to the sarcomas were evaluated simultaneously. <br />The immunoreactivity was found positive in all osteosarcoma tissues (44/44), but 21.5% (9/44) in normal tissues. HSPgp96 was mainly expressed in cytoplasm of osteoblastic sarcoma, while in nucleus of chondroblastic sarcoma. HSPgp96 immunolabelling had ...
Source: Neoplasma - November 11, 2009 Category: Cancer & Oncology Authors: Guo WC, Zhao SH, Yu L, Tang J, Wu GX, Chen JL Tags: Neoplasma Source Type: journals

Tissue-Selective Regulation of Aromatase Expression by Calcitriol: Implications for Breast Cancer Therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aromatase, the enzyme that catalyzes estrogen synthesis, is critical for the progression of estrogen receptor-positive breast cancer (BCa) in postmenopausal women. We show that calcitriol, the hormonally active form of vitamin D, regulates the expression of aromatase in a tissue-selective manner. Calcitriol significantly decreased aromatase expression in human BCa cells and adipocytes and caused substantial increases in human osteosarcoma cells (a bone cell model exhibiting osteoblast phenotype in culture) and modest increases in ovarian cancer cells. Calcitriol administration to immunocompromised mice bearing human BC...
Source: Endocrinology - November 11, 2009 Category: Endocrinology Authors: Krishnan AV, Swami S, Peng L, Wang J, Moreno J, Feldman D Tags: Endocrinology Source Type: journals

The role of interferons in the treatment of osteosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the rationale for the use of interferon in cancer with special reference to the treatment of osteosarcoma, including all published data of clinical efficacy in this disease. Pediatr Blood Cancer © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 10, 2009 Category: Cancer & Oncology Authors: Jeremy Whelan, Daniel Patterson, Martha Perisoglou, Stefan Bielack, Neyssa Marina, Sigbjorn Smeland, Mark Bernstein Source Type: journals

Long-Term Evaluation of Ifosfamide-Related Nephrotoxicity in Children [Pediatric Oncology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Renal toxicity is moderate with a moderate dose of ifosfamide. However, since it can be permanent and can get worse with time, repeated long-term evaluations are important, and this risk should be balanced against efficacy. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Authors: Oberlin, Fawaz, Rey, Niaudet, Ridola, Orbach, Bergeron, Defachelles, Gentet, Schmitt, Rubie, Munzer, Plantaz, Deville, Minard, Corradini, Leverger, de Vathaire Tags: Long Term Survival & Late Effects, osteosarcoma & Ewing sarcomas:, Chemotherapy, Rhabdo & Other Soft Tissue sarcomas:, Chemotherapy Pediatric Oncology Source Type: journals

Identification of the GATA Factor TRPS1 as a Repressor of the Osteocalcin Promoter [Transcription, Chromatin, and Epigenetics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A proteomic analysis of proteins bound to the osteocalcin OSE2 sequence of the mouse osteocalcin promoter identified TRPS1 as a regulator of osteocalcin transcription. Mutations in the TRPS1 gene are responsible for human tricho-rhino-phalangeal syndrome, which is characterized by skeletal and craniofacial abnormalities. TRPS1 has been shown to bind regulatory promoter sequences containing GATA consensus binding sites and to repress transcription of genes involved in chondrocyte differentiation. Here we show that TRPS1 can directly bind the osteocalcin promoter in the presence or absence of Runx2. TRPS1 binds through a GAT...
Source: Journal of Biological Chemistry - November 6, 2009 Category: Chemistry Authors: Piscopo, D. M., Johansen, E. B., Derynck, R. Tags: Transcription, Chromatin, and Epigenetics Source Type: journals

Approved Lymphoma Drug Shows Promise In Early Tests Against Bone CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A drug already approved for the treatment of lymphoma may also slow the growth of the most deadly bone cancer in children and teens, according to an early-stage study published online in the International Journal of Cancer. The study drug, Bortezomib, was found to be effective against bone cancer in human cancer cell studies and in mice. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 6, 2009 Category: Cancer & Oncology Tags: Bones / Orthopaedics Source Type: news

Approved Lymphoma Drug Shows Promise In Early Tests Against Bone CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A drug already approved for the treatment of lymphoma may also slow the growth of the most deadly bone cancer in children and teens, according to an early-stage study published online in the International Journal of Cancer. The study drug, Bortezomib, was found to be effective against bone cancer in human cancer cell studies and in mice. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 6, 2009 Category: Consumer Health News Tags: Bones / Orthopaedics Source Type: news

Approved Lymphoma Drug Shows Promise in Early Tests Against Bone CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ROCHESTER, N.Y., Nov. 5 /PRNewswire-USNewswire/ -- A drug already approved for the treatment of lymphoma may also slow the growth of the most deadly bone cancer in children and teens, according to an early-stage study published online today in... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - November 5, 2009 Category: Pharmaceuticals Source Type: clinical trials

Approved lymphoma drug shows promise in early tests against bone cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(University of Rochester Medical Center) A drug already approved for the treatment of lymphoma may also slow the growth of the most deadly bone cancer in children and teens, according to an early-stage study published online today in the International Journal of Cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 5, 2009 Category: Global & Universal Source Type: news

Noninvasive Imaging Surrogate of Angiogenesis in OsteosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests an important role of DCE-MRI as a noninvasive imaging surrogate of tumor angiogenesis in osteosarcoma based on visual inspection of TIC. Pediatr Blood Cancer. © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Jyoti Bajpai, Shivanand Gamanagatti, Mehar C. Sharma, Rakesh Kumar, Sreenivas Vishnubhatla, Shah Alam Khan, Shishir Rastogi, Arun Malhotra, Sameer Bakhshi Source Type: journals

Prognostic factors in pulmonary metastasized high-grade osteosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Resection of pulmonary metastases has previously been reported to improve outcome in high-grade osteosarcoma (OS) patients. Factors influencing survival in OS patients with pulmonary metastases are important for clinical decision making.All 88 OS patients with pulmonary metastases either at diagnosis or during follow-up treated at the Leiden University Medical Center between January 1, 1990 and January 1, 2008 under the age of 40 were included in this study, including 79 cases of conventional, 8 cases of telangiectatic and 1 case of small cell OS.In total, 56 of 88 patients with pulmonary metastases were treated by metasta...
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Emilie P. Buddingh, Jakob K. Anninga, Michel I.M. Versteegh, Antonie H.M. Taminiau, R. Maarten Egeler, Catherina S.P. van Rijswijk, Pancras C.W. Hogendoorn, Arjan C. Lankester, Hans Gelderblom Source Type: journals

Isolated CNS vasculitis: Unusual presentation of relapsed Ewing sarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 12-year-old boy male who presented with an expressive dysphasia after completion of treatment for unifocal Ewing sarcoma. CNS vasculitis was diagnosed by MRI/MRA and cerebral angiography. Extensive rheumatologic work-up failed to identify an underlying primary process. Restaging studies showed no evidence of tumor. Complete neurologic recovery was achieved on prednisone. Four months later the patient developed overt, extensive metastases, confirmed by biopsy to represent recurrent Ewing sarcoma. Despite intensive therapy the patient succumbed 6 months later. This case demonstrates the unique finding of isolat...
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Polina Stepensky, Elisha Waldman, Natalia Simanovsky, Iris Fried, Shoshana Revel-Vilk, Igor B. Resnick, Michael Weintraub Source Type: journals

Wnts, bone and cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Wnt pathway plays vital roles in bone and in cancer. In this issue of The Journal of Pathology, Cai and colleagues report results that suggest that the Wnt pathway is inactivated in bone cancers, a finding that could have significant implications for the development of Wnt agonists as bone anabolic agents. While these findings are at odds with the prevailing view that the Wnt pathway is oncogenic in all systems studied to date, they remind us how complex and still poorly understood this important signalling pathway remains. At the very least, these findings should provoke debate and stimulate further research into the ...
Source: The Journal of Pathology - November 3, 2009 Category: Pathology Authors: David M Thomas Source Type: journals

Staged Lengthening Arthroplasty for Pediatric Osteosarcoma around the Knee.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our approach is one option for skeletally immature patients, especially in situations where an expandable prosthesis is not available. However, this technique requires multiple stages and would be inappropriate for patients who cannot accept prolonged functional deficit owing to a limited lifespan or other reasons. LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence. PMID: 19885713 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - November 3, 2009 Category: Orthopaedics Authors: Kong CB, Lee SY, Jeon DG Tags: Clin Orthop Relat Res Source Type: journals

Innovative Trident Fixation Technique for Allograft Knee Arthrodesis for High-grade Osteosarcoma around the KneeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This straightforward technique was successful in knee arthrodesis with minimized limb length inequality. Accordingly, in light of bone stock preservation and longevity for the young children, it may be a surgical alternative for malignant bone tumors around the knee. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Su, A. W., Chen, W.-M., Chen, C.-F., Chen, T.-H. Tags: Original Articles Source Type: journals

Synergistic Increase in Osteosarcoma Cell Sensitivity to Photodynamic Therapy with Aminolevulinic Acid Hexyl Ester in the Presence of HyperthermiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Photomedicine and Laser Surgery Oct 2009, Vol. 27, No. 5: 791-797. (Source: Photomedicine and Laser Surgery)
Source: Photomedicine and Laser Surgery - November 1, 2009 Category: Laser Surgery Tags: article Source Type: journals

Neoplastic conditions of working dogsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The South African Police Services (SAPS) Roodeplaat Veterinary Hospital serves as a referral hospital for the working dogs of the SAPS. As such, many diverse medical and surgical conditions are seen, including a wide range of malignant neoplastic conditions. The main breed of dog used in the SAPS is the German shepherd dog (GSD), followed by the Rottweiler and the Belgian shepherd dog, or Malanois. These breeds are all large breeds and are therefore prone to certain types of tumors that occur more commonly in the large breeds. The average lifespan of the working dog in the South African security services is 8 to 10 years, ...
Source: Journal of Veterinary Behavior: Clinical Applications and Research - November 1, 2009 Category: Veterinary Research Authors: J.R. Birrell Tags: Abstracts Source Type: journals

MR Imaging of Primary Bone Tumors and Tumor-like Conditions in ChildrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides a review of the MR imaging features of the major primary malignant and benign bone tumors and tumorlike conditions encountered in the pediatric population. Malignant tumors discussed include osteosarcoma, Ewing sarcoma, chondrosarcoma, lymphoma, and malignant fibrous histiocytoma. Benign lesions discussed include simple bone cysts, aneurysmal bone cysts, giant cell tumor, osteochondroma, enchondroma, chondroblastoma, osteoid osteoma, osteoblastoma, nonossifying fibroma, fibrous dysplasia, osteofibrous dysplasia, hemangioma, and histiocytosis. The use of MR imaging in the diagnosis of these lesions is ...
Source: Radiologic Clinics of North America - November 1, 2009 Category: Radiology Authors: Sandra L. Wootton-Gorges Source Type: journals

Primary bone lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary bone lymphomas are rare, even though secondary involvement of the bone marrow is a common event in systemic lymphomas. Most primary bone lymphomas are primary bone diffuse large B-cell lymphomas (PBDLBCLs) with a rare occurrence of follicular, marginal zone, anaplastic large cell, Hodgkin, and T-cell lymphomas. The PBDLBCL affects the middle-aged to elderly population, with a slight predominance in men. The patients present with bone pain, palpable mass, fractures, or neurologic symptoms. The metaphysis of bones is a common location of PBDLBCL. Morphologically, the lymphoma consists of a polymorphous mixture of...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Bhagavathi S, Fu K Tags: Arch Pathol Lab Med Source Type: journals

Sarcomatoid chromophobe renal cell carcinoma with heterologous sarcomatoid elements. A case report and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chromophobe renal cell carcinoma (CRCC) is a distinct subtype of renal cell carcinoma (RCC) that is well known for its relatively good prognosis. Sarcomatoid transformation in this tumor, although rare, has been well documented in the literature and, as in other types of RCC, carries an ominous prognosis for the patient. The finding of heterologous elements in the sarcomatoid component of CRCC is an extraordinary event, which has been reported in only 2 previous cases. Here, we present the third such case, occurring in the left kidney of a previously healthy 63-year-old woman. The nephrectomy specimen showed CRCC with ...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Quiroga-Garza G, Khurana H, Shen S, Ayala AG, Ro JY Tags: Arch Pathol Lab Med Source Type: journals

MR imaging of primary bone tumors and tumor-like conditions in children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides a review of the MR imaging features of the major primary malignant and benign bone tumors and tumor-like conditions encountered in the pediatric population. Malignant tumors discussed include osteosarcoma, Ewing sarcoma, chondrosarcoma, lymphoma, and malignant fibrous histiocytoma. Benign lesions discussed include simple bone cysts, aneurysmal bone cysts, giant cell tumor, osteochondroma, enchondroma, chondroblastoma, osteoid osteoma, osteoblastoma, nonossifying fibroma, fibrous dysplasia, osteofibrous dysplasia, hemangioma, and histiocytosis. The use of MR imaging in the diagnosis of these lesions is...
Source: Radiologic Clinics of North America - November 1, 2009 Category: Radiology Authors: Wootton-Gorges SL Tags: Radiol Clin North Am Source Type: journals

Synchronous and metachronous skeletal osteosarcomas: the Norwegian Radium Hospital experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. The prognosis for patients with synchronous and metachronous skeletal osteosarcoma is poor. However, because long-term survival is seen, aggressive treatment to selected cases, e.g., patients with an osteosarcoma predisposing syndrome and/or late occurring metachronous tumours, is justified. Revealing a possible clonal relationship between these tumors, e.g., by karyotyping, may be of interest for estimating prognosis and guide therapy intensiveness. PMID: 19863225 [PubMed - in process] (Source: Acta Oncologica)
Source: Acta Oncologica - October 31, 2009 Category: Cancer & Oncology Authors: Brandal P, Bjerkehagen B, Bruland OS, Skjeldal S, Bogsrud TV, Hall KS Tags: Acta Oncol Source Type: journals

In Medical First, Packard Children's Orthopedic Surgeon Implants High-Tech Artificial Bone In Three-Year-Old's ArmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When little Mark Blinder was diagnosed with a rare bone cancer, doctors at Lucile Packard Children's Hospital gave his parents three agonizing options: amputate the affected arm at the shoulder, irradiate the tumor and risk a second malignancy, or try a limb-preserving surgery that had never been attempted in a toddler. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 28, 2009 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Cell cycle inhibition and apoptosis induced by curcumin in Ewing sarcoma cell line SK-NEP-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Curcumin is a naturally occurring polyphenolic compound found in the turmeric, which is used as food additive in Indian cooking and as a therapeutic agent in traditional Indian medicine. Curcumin is currently under investigation as a chemotherapeutic and chemopreventive agent in adult cancer models at both pre-clinical and clinical levels. In this preliminary study, we show that curcumin is effective in causing cell cycle arrest, inducing apoptosis, and suppressing colony formation in the Ewing sarcoma cell line SK-NEP-1. Curcumin causes upregulation of cleaved caspase 3 and downregulation of phosph...
Source: Medical Oncology - October 27, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Primary Ewing’s sarcoma of the orbit: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A 22-year-old man presented with tenderness and swelling of the left lateral part of the orbit. Computed tomography revealed a left intraorbital mass measuring 3 cm × 3 cm involving the left lateral wall of the orbit and the greater wing of the left sphenoid bone. Magnetic resonance imaging revealed that the intraorbital mass was extraneuroaxial. During surgery, the tumor was seen to arise from the lateral wall of the orbit and infiltrate into the left temporal muscle. Following the surgery, the patient was administered radiation therapy for the whole cranium and chemotherapy for the residual tumor...
Source: Brain Tumor Pathology - October 26, 2009 Category: Neurology Tags: Brain Tumor Pathology Source Type: journals

Use of force plate analysis to evaluate the efficacy of external beam radiation to alleviate osteosarcoma painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A standard of therapy for osteosarcoma includes amputation with or without adjuvant chemotherapy. There is a subset of dogs with osteosarcoma that are unsuitable for amputation. We evaluated kinetic variables in dogs with appendicular osteosarcoma treated with a single 8 Gy dose of radiation. Eighteen pet dogs with appendicular osteosarcoma received one 8 Gy fraction of palliative radiation on day 0. Force plate measurements and clinical assessments were made on days 0, 7, 14, and 21. Peak vertical forces (Fz) were recorded for each limb and a symmetric index (SI) was calculated. There were no significant changes in kineti...
Source: Veterinary Radiology & Ultrasound - October 26, 2009 Category: Veterinary Research Authors: JEFF I. WEINSTEIN, SARAH PAYNE, JEAN M. POULSON, CHIEKO AZUMA Tags: RADIATION ONCOLOGY Source Type: journals

Orthopedic Oncologist Treats Musculoskeletal TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bone cancer, as a primary cancer diagnosis, is not a common form of cancer in the United States. It makes up less than one percent of all cancers, with approximately 2,300 people newly diagnosed last year. Thomas R. Bowen, M.D., is a fellowship-trained, board-certified orthopedic oncologist specializing in the diagnosis and treatment of musculoskeletal tumors. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 23, 2009 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Importance and mechanism of 'switch' function of SAP family adaptersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: The signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) family of adapters includes SAP, Ewing's sarcoma-associated transcript-2 (EAT-2), and EAT-2-related transducer (ERT). These Src homology-2 (SH2) domain-only molecules play critical roles in immune regulation. The prototype of the SAP family, SAP, is mutated in X-linked lymphoproliferative disease in humans. Moreover, genetically engineered mice lacking one or more SAP family members have defects in multiple immune cell types including T cells, natural killer (NK) cells, NKT cells, and B cells. Accumulating data show that SAP family adapt...
Source: Immunological Reviews - October 23, 2009 Category: Allergy & Immunology Authors: André Veillette, Zhongjun Dong, Luis-Alberto Pérez-Quintero, Ming-Chao Zhong, Mario-Ernesto Cruz-Munoz Tags: Review Articles Source Type: journals

Acanthamoeba spp.: in vitro effects of clinical isolates on murine macrophages, osteosarcoma and HeLa cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates the ability of these amoebae to degrade any of the tested cell lines. To the best of our knowledge, this is the first report of the in vitro effects of acanthamoebae on osteosarcoma cells. PMID: 19857490 [PubMed - as supplied by publisher] (Source: Experimental Parasitology)
Source: Experimental Parasitology - October 23, 2009 Category: Parasitology Authors: Martín-Navarro CM, Lorenzo-Morales J, Machín RP, López-Arencibia A, Valladares B, Piñero JE Tags: Exp Parasitol Source Type: journals

Ewing sarcoma of the neckEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Sandrin Schmidt, Herwig Lackner, Christian Urban Source Type: journals

Gene Duplication Identified in an Uncommon Form of Bone CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
: Scientists discover that a familial form of a rare bone cancer called chordoma is explained not by typical types of changes or mutations in the sequence of DNA in a gene, but rather by the presence of a second copy of an entire gene. The findings appeared online Oct. 4, 2009, in Nature Genetics and was done by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues. NHGRI researcher David Ng co-authored the study. (Source: NHGRI-Related News)
Source: NHGRI-Related News - October 21, 2009 Category: Genetics & Stem Cells Source Type: news

Air Embolism and Needle Track Implantation Complicating CT-Guided Percutaneous Thoracic Biopsy: Single-Institution ExperienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION. The incidence of air embolism with clinical symptoms and needle track implantation complicating percutaneous thoracic biopsy is more frequent than the previously reported rate. (Source: American Journal of Roentgenology)
Source: American Journal of Roentgenology - October 20, 2009 Category: Radiology Authors: Ibukuro, K., Tanaka, R., Takeguchi, T., Fukuda, H., Abe, S., Tobe, K. Tags: Vascular and Interventional Radiology Source Type: journals

Histological heterogeneity of Ewing’s sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical supportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the diagnosis of atypical ES is a challenge for the pathologist and needs support from molecular techniques to perform an optimal differential diagnosis with other small round cell tumors. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00428-009-0842-7Authors Antonio Llombart-Bosch, University of Valencia Department of Pathology Ave. Blasco Ibañez, 17 46010 Valencia SpainIsidro Machado, University of Valencia Department of Pathology Ave. Blasco Ibañez, 17 46010 Valencia SpainSamuel Navarro, University of Valencia Department of Pathology Ave. Blasco Ibañez, 17 46010 Valencia SpainF...
Source: Virchows Archiv - October 20, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Spectroscopic Behavior and Biological Activity of K(2)[VO(O (2))NTA].2H (2)O.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The dihydrated potassium salt of the complex anion [VO(O(2))NTA](2-) (NTA = nitrilotriacetate anion, [N(CH(2)-COO)(3)](3-)) was thoroughly characterized by electronic and vibrational (infrared and Raman) spectroscopies. The bioactivity of the complex on the cell proliferation was tested on three cell lines in culture (UMR106 rat osteosarcoma-derived cells, Caco-2 derived from a human colon adenocarcinoma, and RAW 264.7, a macrophage murine cell line). PMID: 19841872 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - October 19, 2009 Category: Biology Authors: Arrambide G, Barrio DA, Etcheverry SB, Gambino D, Baran EJ Tags: Biol Trace Elem Res Source Type: journals

Scientists Find Cause Of Familial ChordomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DURHAM, N.C. -- U.S. scientists say they've found a genetic alteration is the cause of familial chordoma, an uncommon bone cancer that also affects the nervous system. Duke University Medical Center and National Cancer Institute researchers said the genetic alteration -- a second copy of an entire gene -- produces inherited differences in gene copy number, known as copy number variation, that have been implicated in some hereditary diseases. "This alteration is unlike anything we have ever seen before in families that tend to develop the same kind of cancers," said Dr. Michael Kelley, an associate professor at Duke Univers...
Source: Cancercompass News: Other Cancer - October 19, 2009 Category: Cancer & Oncology Source Type: news

Metastatic potential of an aneurysmal bone cystEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Aneurysmal bone cysts (ABCs) are benign bone tumors consisting of blood-filled cavities lined by connective tissue septa. Recently, the hypothesis that ABCs are lesions reactive to local hemodynamics has been challenged after the discovery of specific recurrent chromosomal abnormalities. Multiple cases of malignant transformation of ABC into (osteo)sarcoma have been described, as well as a number of cases of telangiectatic osteosarcoma which had been misdiagnosed as ABC. We herewith document a case of a pelvic ABC metastatic to the lung, liver, and kidneys. Diagnosis was confirmed by the presence of...
Source: Virchows Archiv - October 16, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals