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5474 records returned

[Effect of cytotoxin interleukin-2-pseudomonas exotoxin 66 on corneal allograft rejection in mice.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: IL-2-PE66 can delay the development of corneal graft rejection, significantly reduce the percentage of T helper cells, and weaken the aggregation of the peripheral T cells. PMID: 19923053 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Wu J, Yu J Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

Biological Rationale for the Intramedullary Canal as a Source of Autograft MaterialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bone harvested by intramedullary reaming offers a minimally invasive alternative to harvesting bone from the iliac crest, which has long been considered the gold standard for autogenous bone grafting. The biologic potential of intramedullary reaming material has been studied both in vitro and in vivo. The material provides osteogenic, osteoinductive, and osteoconductive properties that are comparable to the material harvested from the iliac crest. In addition to the ability to obtain a large volume of bone, the graft harvested by the Reamer-Irrigator-Aspirator has been shown to be rich in growth factors, including BMP-2, T...
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: David J. Hak, Jason L. Pittman Source Type: journals

Treatment of Large Segmental Bone Defects with Reamer-Irrigator-Aspirator Bone Graft: Technique and Case SeriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Treatment of large segmental defects using conventional autogenous iliac crest bone graft can be limited by volume of cancellous bone and donor site morbidity. The reamer-irrigator-aspirator (RIA) technique allows access to a large volume of cancellous bone graft containing growth factors with potency equal to or greater than autograft material from the iliac crest. The purpose of this study was to evaluate the effectiveness of RIA-harvested autogenous bone graft for treating large segmental defects of long bones. (Source: Orthopedic Clinics of North America)
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: Todd A. McCall, David S. Brokaw, Bradley A. Jelen, D. Kevin Scheid, Angela V. Scharfenberger, Dean C. Maar, James M. Green, Melanie R. Shipps, Marcus B. Stone, Dana Musapatika, Timothy G. Weber Source Type: journals

Autograft and Nonunions: Morbidity with Intramedullary Bone Graft versus Iliac Crest Bone GraftEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article focuses on comparing patient morbidity with harvesting bone graft for the treatment of nonunions from three different sites. Anterior iliac crest graft is the most commonly used site; however, the posterior iliac crest and intramedullary canal provide greater quantities of bone. The anterior and posterior iliac crests also have some donor site complications such as nerve injury and persistent pain. The intramedullary canal, when compared with anterior and posterior iliac crest, offers the largest quantity of bone graft with the least amount of patient donor site morbidity. The intramedullary canal also appears...
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: Janet D. Conway Source Type: journals

Autologous Bone Graft: When Shall We Add Growth Factors?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although the unquestionable value of autologous bone grafting and the analogous value of the reaming by-products in nonunion treatment have been mentioned extensively in the literature, there is ongoing vivid discussion for the treatment of those case scenarios where the fracture nonunion is complicated by other local environment adverse circumstances. The graft expansion with growth factors as the bone morphogenetic proteins (BMPs) offers the possibility to reduce the number of operative procedures, complications, length of hospital stay, and time to union. In this article, we consider the potential clinical scenarios for...
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: Peter V. Giannoudis, Haralampos T. Dinopoulos Source Type: journals

Quantitative Analysis of Growth Factors from a Second Filter Using the Reamer-Irrigator-Aspirator System: Description of a Novel TechniqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on our novel technique of using a second filter containing beta-tricalcium phosphate (TCP) as a graft extender while using the RIA system. We also quantify growth factor concentrations in the collections from the TCP filter. A second filter attached in series with the standard RIA filtration system yields TCP with substantial concentrations of bioactive proteins that are equal to those seen in the bone graft that is harvested in the first filter. (Source: Orthopedic Clinics of North America)
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: James P. Stannard, Ashoke K. Sathy, Fariba Moeinpour, Rena L. Stewart, David A. Volgas Source Type: journals

RIA: One Community's ExperienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Reamer Irrigator Aspirator (RIA) has three main indications in our community trauma practice. The most common indication for RIA is harvesting of autololgous bone graft from the femur for nonstructural bone graft. The second most common indication is for irrigation and debridement of intramedullary osteomyelitis. The final indication for RIA is for acute nailing of femoral shaft fractures in patients with multiple long bone fractures with or without pulmonary injury. If one pays careful attention to the details of the technique, RIA is a safe and effective method of harvesting autologous bone graft with minimal morbidi...
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: Christopher G. Finkemeier, Rafael Neiman, Domingo Hallare Source Type: journals

Managing Bone Deficiency and Nonunions of the Proximal FemurEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article presents a technique of deformity correction, bone graft techniques that reconstitute residual defects, and definitive fixation using load-sharing devices that provide immediate stability for bone healing and early rehabilitation. Preoperative planning and the potential advantages and disadvantages of newer fixed-angled plates versus established implants are discussed. With proper planning, surgical execution with proved techniques, augmented by the addition of newer graft harvesting techniques, anatomic restoration, and bone reconstitution with healing, has invariably been the result. (Source: Orthopedic Clin...
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: John J. Perry, Brent Winter, Jeffrey W. Mast Source Type: journals

Viable Bone and Circulatory Factors Required for Survival of Bone GraftsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The healing of fractures and nonunions has significant science background to it; however, the application of the products in the surgeon's hands should be considered an art in the science of bone healing. The surgeon must choose adequate fixation for stability and to promote healing by not making the construct too stiff. If a bone graft substitute is necessary, the surgeon must choose the type of bone graft substitute depending on patient factors and surgeon factors involving the treatment of the fracture. (Source: Orthopedic Clinics of North America)
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: Lisa K. Cannada Source Type: journals

Use of Solid and Cancellous Autologous Bone Graft for Fractures and NonunionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article describes the use of solid and cancellous bone graft in the treatment of acute bone loss and nonunion. (Source: Orthopedic Clinics of North America)
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: James T. Marino, Bruce H. Ziran Source Type: journals

The Concept of Induced Membrane for Reconstruction of Long Bone DefectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical, experimental, and fundamental studies have shown the interest of a foreign body-induced membrane to promote the consolidation of a conventional cancellous bone autograft for reconstruction of long bone defects. The main properties of the membrane are to prevent the resorption of the graft and to secrete growth factors. The induced membrane appears as a biological chamber, which allows the conception of numerous experimental models of bone reconstruction. This concept could probably be extended to other tissue repair. (Source: Orthopedic Clinics of North America)
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: Alain C. Masquelet, Thierry Begue Source Type: journals

Clinical Use of Resorbable Polymeric Membranes in the Treatment of Bone DefectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The reconstruction of large bone defects remains a clinically challenging condition. Although many treatment approaches exist, they all have limitations. Recently, bioresorbable polylactide membranes have become commercially available. These membranes, when applied to bone defects, enhance bone healing by direct osteoconduction, exclusion of nonosseous tissues, and enhancing the osteogenic environment for autologous grafts. When combined with appropriate internal fixation and autologous bone graft, bioresorbable polylactide membranes allow for single-step reconstruction of large bone defects. (Source: Orthopedic Clinics of North America)
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: Richard P. Meinig Source Type: journals

Use of the Induced Membrane Technique for Bone Tissue Engineering Purposes: Animal StudiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Animal experiments using the induced membrane procedure for bone tissue engineering purposes have provided evidence that the membrane has structural characteristics and biologic properties that may be used for bone tissue engineering purposes. Clinically relevant animal models have demonstrated that standardized particulate bone constructs can be used to repair large bone defects using the procedure and that the osteogenic ability of these constructs partially approaches that of bone autografts. (Source: Orthopedic Clinics of North America)
Source: Orthopedic Clinics of North America - November 19, 2009 Category: Orthopaedics Authors: Véronique Viateau, Morad Bensidhoum, Geneviève Guillemin, Hervé Petite, Didier Hannouche, Fani Anagnostou, Philippe Pélissier Source Type: journals

Fresh-frozen vs. irradiated allograft bone in orthopaedic reconstructive surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The use of allograft bone is increasingly common in orthopaedic reconstruction procedures. The optimal method of preparation of allograft bone is subject of great debate. Proponents of fresh-frozen graft cite improved biological and biomechanical characteristics relative to irradiated material, whereas fear of bacterial or viral transmission warrants some to favour irradiated graft. Careful review of the literature is necessary to appreciate the influence of processing techniques on bone quality. Whereas limited clinical trials are available to govern the selection of appropriate bone graft, this review presents ...
Source: Injury - November 19, 2009 Category: Orthopaedics Authors: D.J. Costain, R.W. Crawford Tags: Reviews Source Type: journals

Percutaneous plating in paediatric tibial fracturesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: Although non-operative treatment is a mainstay of tibial fracture management in children, certain fractures require a surgical approach. However, choices concerning optimal methods and implants are difficult. The purpose of this study was to determine the effectiveness of percutaneous plating of tibial fractures in children.Materials and methods: Sixteen tibial fractures treated using the percutaneous plating technique between 2000 and 2007 were reviewed. The mean age at operation was 10 years 9 months (range: 6–16 years). There were eight open and closed fractures each. Operative indications were a...
Source: Injury - November 19, 2009 Category: Orthopaedics Authors: Nazri Mohd Yusof, Chang-Wug Oh, Jong-Keon Oh, Joon-Woo Kim, Woo-Kie Min, Il-Hyung Park, Hee-June Kim Tags: Articles Source Type: journals

Fracture healing and bone regeneration: Autologous bone grafting or BMPs?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 1915, autologous bone grafting was introduced as a useful surgical technique in the clinical setting. It was not long before its efficacy and safety was recognised and nowadays it is no surprise that over half a million graft harvesting procedures are performed annually in the USA. Common autologous bone graft harvesting sites include the pelvis (anterior/posterior iliac crest), proximal tibia, femur, and distal radius. (Source: Injury)
Source: Injury - November 19, 2009 Category: Orthopaedics Authors: Peter V. Giannoudis Tags: Editorial Source Type: journals

Reconstruction of Mandibular Continuity Defects Using Recombinant Human Bone Morphogenetic Protein 2: A Note of Caution in an Atmosphere of ExuberanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Loss of mandibular continuity most commonly occurs because of traumatic, infectious, or neoplastic processes and can be psychologically and physiologically debilitating. The goals of mandibular reconstruction are the restoration of appearance, mastication, deglutition, speech, and oral competence. Although the timing and prioritization of these goals within the context of ablative surgery have been controversial, it is clear that successful reconstruction of bony defects is dependent on the survival of the transplanted tissue, which in turn is dependent on an adequate blood supply or soft tissue envelope. Numerous reconstr...
Source: Journal of Oral and Maxillofacial Surgery - November 19, 2009 Category: ENT & OMF Authors: R. Bryan Bell, Curtis Gregoire Tags: Clinical Controversies in Oral and Maxillofacial Surgery: Part One Source Type: journals

HMGB1, an innate alarmin, in the pathogenesis of type 1 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HMGB1, an evolutionarily conserved chromosomal protein, was recently re-discovered to act as a "danger signal" (alarmin) to alert the innate immune system for the initiation of host defense or tissue repair. Extracellular HMGB1 can be either passively released from damaged/necrotic cells or secreted by activated immune cells. Upon stimulation, dendritic cells (DCs), macrophages and natural killer (NK) cells secrete high levels of HMGB1 into the intercellular milieu. HMGB1 is potent to target DCs, macrophages, neutrophils and CD4(+) T cells. It also upregulates the expression of BCL-XL by which it may prevent the elimin...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Zhang S, Zhong J, Yang P, Gong F, Wang CY Tags: Int J Clin Exp Pathol Source Type: journals

Functional and morphologic evaluation of kidney proximal tubuli and correlation with renal allograft prognosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the histologic pattern associated with PTD and its correlation with graft outcome. Forty-nine transplant patients with stable graft function were submitted to a biopsy. Simultaneously, urinary retinol-binding protein (uRBP) was measured and creatinine clearance was also determined. Banff's score and semi-quantitative histologic analyses were performed to assess tubulointerstitial alterations. Patients were followed for 24.0 ± 7.8 months. At biopsy time, mean serum creatinine was 1.43 ± 0.33 mg/dl. Twelve patients (24.5%) had uRBP [ge]1 mg/l, indicating PTD and 67% of biopsies had some degre...
Source: Transplant International - November 19, 2009 Category: Transplant Surgery Authors: Ana Cristina Carvalho de Matos, Niels Olsen Saraiva Câmara, Ana Francisca Franco de Oliveira, Marcello F. Franco, Luiz Antonio Ribeiro Moura, Sonia Nishida, Aparecido Bernardo Pereira, Alvaro Pacheco-Silva Source Type: journals

[Sexuality after kidney transplantation.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The quality of life of patients after kidney transplantation is of increasing interest. In this connection, issues of sexuality are meaningful too. Many patients with end-stage kidney disease suffer from sexual disorders. More than 50% of the male patients on dialysis and even more females are affected by disturbances such as erectile dysfunction and loss of libido or abnormal menstrual cycles. After successful kidney transplantation most symptoms in women are improved, whereas in men disturbances in erectile function often persist or even deteriorate. In these patients treatment with inhibitors of phosphodiesterase ty...
Source: Der Urologe. Ausg. A - November 19, 2009 Category: Urology & Nephrology Authors: Steiner T, Wunderlich H, Ott U Tags: Urologe A Source Type: journals

Fracture of the tibial bone block after posterior cruciate ligament allograft reconstruction using double cross pinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the fracture of the tibial bone block after posterior cruciate ligament reconstruction using double cross pins for bone block fixation in the postoperative period. The possible reasons include the size of bone block, direction of cross pin or the quality of bone block. This case emphasizes the biomechanical properties and failure of modes of double cross pin. Content Type Journal ArticleCategory Arthroscopy and Sports MedicineDOI 10.1007/s00402-009-1005-7Authors Hong Chul Lim, Korea University College of Medicine, Guro Hospital Department of Orthopaedic Surgery 80 Guro-dong, Guro-gu Seoul 152-703 Republic ...
Source: Archives of Orthopaedic and Trauma Surgery - November 18, 2009 Category: Orthopaedics Tags: Archives of Orthopaedic and Trauma Surgery Source Type: journals

Evolution of open-wedge high-tibial osteotomy: experience with a special angular stable device for internal fixation without interposition materialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we believe that open-wedge high-tibial osteotomy using the TomoFix® plate has proved to be successful in treating unicompartmental gonarthrosis, even without bone grafts or bone-substitute material. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00264-009-0902-2Authors Alex E. Staubli, Orthopaedic Surgery, Privatklinik Sonnmatt Hemschlenstrasse 6000 Lucerne 15 SwitzerlandHilaire A. C. Jacob, Orthop. Biomechanics Gernstrasse 128 8409 Winterthur Switzerland Journal International OrthopaedicsOnline ISSN 1432-5195Print ISSN 0341-2695 (Source: International Orthopaedics)
Source: International Orthopaedics - November 18, 2009 Category: Orthopaedics Tags: International Orthopaedics Source Type: journals

An Anterior Ablation Line Is Preferred for Perimitral Flutter After Heart TransplantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report 2 cases where an anterior ablation line was easily performed to eliminate perimitral flutter and produce bidirectional block. (J Cardiovasc Electrophysiol, Vol. pp. 1[ndash]3) (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - November 18, 2009 Category: Cardiology Authors: BHAVANESH MAKANJEE, GEORGE J. KLEIN, NICHOLAS DERVAL, ALLAN C. SKANES Source Type: journals

Antibody-mediated rejection of renal allograft in combined liver–kidney transplantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of CLKT in a sensitized patient with antibody-mediated rejection (AMR) of the renal allograft. AMR was confirmed with C4d staining and serial monitoring of donor-specific antibody (DSA). Despite intensive therapy directed against AMR and the presence of the liver allograft, the patient demonstrated increasing titers of alloantibody, never demonstrated adequate renal function, and ultimately expired after two months. This result demonstrates the potential for AMR of the renal allograft in sensitized recipients of CLKT. (Source: Clinical Transplantation)
Source: Clinical Transplantation - November 18, 2009 Category: Transplant Surgery Authors: Rolf N. Barth, Luis Campos, Debra L. Kukuruga, Cinthia Drachenberg, Benjamin Philosophe Source Type: journals

Endothelial dysfunction in hemodialysis patients with failed renal transplantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: ED is more prominent in fTx-HD than the nHD patients. Inflammation, caused by failed renal allograft can be responsible for this abnormality. (Source: Clinical Transplantation)
Source: Clinical Transplantation - November 18, 2009 Category: Transplant Surgery Authors: Numan Gorgulu, Berna Yelken, Yasar Caliskan, Ali Elitok, Arif Oguzhan Cimen, Halil Yazici, Huseyin Oflaz, Ebru Golcuk, Ahmet Ekmekci, Aydin Turkmen, Alaattin Yildiz, Mehmet Sukru Sever Source Type: journals

Prospective study of polyomavirus BK replication and nephropathy in renal transplant recipients in China: a single-center analysis of incidence, reduction in immunosuppression and clinical courseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Choice of FK506 as immunosuppressive agent is an independent risk factor affecting BKV infection. Monitoring and pre-emptive of immunosuppression reduction were associated with resolution of viremia and showed effective in BKVAN recipients at the early stage without acute rejection or graft loss. Quantitative count of urine cytology is a very convenient, useful, and sensitive method for evaluating BKV infection in renal transplant recipients. (Source: Clinical Transplantation)
Source: Clinical Transplantation - November 18, 2009 Category: Transplant Surgery Authors: Gang Huang, Li-Zhong Chen, Jiang Qiu, Chang-Xi Wang, Ji-Guang Fei, Su-Xiong Deng, Jun Li, Guo-Dong Chen, Lei Zhang, Qian Fu, Wen-Tao Zeng, Da-Qiang Zhao Source Type: journals

Percutaneous nephrolithotomy and cystolithalapaxy for a "forgotten" stent in a transplant kidney: case report and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case report of a renal transplant patient with a heavily encrusted forgotten stent. We employed a simultaneous approach, using percutaneous nephrostolithotomy and cystolithalapaxy, for complete removal of the encrusted stent and associated stones. A MEDLINE literature review was then performed to identify and analyze similar cases in which a forgotten stent in a renal allograft was removed. Our experience and that found in the medical literature suggest that removal of forgotten stents can be achieved safely and effectively with proper endourological techniques. We also reviewed the current status of ureteral ...
Source: Clinical Transplantation - November 18, 2009 Category: Transplant Surgery Authors: Yevgeniy Veltman, John M. Shields, Gaetano Ciancio, Vincent G. Bird Source Type: journals

Decreasing plasma soluble IL-1 receptor antagonist and increasing monocyte activation early post-transplant may be involved in pathogenesis of delayed graft function in renal transplant recipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sadeghi M, Daniel V, Naujokat C, Schmidt J, Mehrabi A, Zeier M, Opelz G. Decreasing plasma soluble IL-1 receptor antagonist and increasing monocyte activation early post-transplant may be involved in pathogenesis of delayed graft function in renal transplant recipientsClin Transplant 2009 DOI: 10.1111/j.1399-0012.2009.01130.x.© 2009 John Wiley & Sons A/S.Abstract: Delayed graft function (DGF) increases the risk of acute allograft rejection and may affect long-term graft survival. We compared pre-transplant, early post-transplant, and late post-transplant serum creatinine (Cr) and plasma levels of neopterin, cytokines, and...
Source: Clinical Transplantation - November 18, 2009 Category: Transplant Surgery Authors: Mahmoud Sadeghi, Volker Daniel, Cord Naujokat, Jan Schmidt, Arianeb Mehrabi, Martin Zeier, Gerhard Opelz Source Type: journals

Controlled antegrade single lung reperfusion during double lung transplant [New ideas - Pulmonary]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prompt controlled reperfusion of a pulmonary allograft in a sequential double lung transplant may correct cellular ischemia prior to exposure to full hydrostatic pressures and minimize organ dysfunction. We reviewed the process of a sequential double lung transplant and describe the technique of controlled antegrade graft reperfusion of the initial implant as performed at our institution. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - November 17, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Khalpey, Z., Gilfeather, M. S., Camp, P. C., Jaklitsch, M. T. Tags: New ideas - Pulmonary Source Type: journals

Role of Cellular Cholesterol in Pharmacologic Preconditioning with Cyclosporine in Experimental Kidney Transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CsA preconditioning leads to better outcomes in kidney transplantation and is associated with up-regulation of renal FC content. The latter may then contribute to acquired cytoresistance, possibly by stabilizing the plasma membrane. Thus, use of statins around the time of transplantation may need to be evaluated until further studies are conducted to determine the clinical relevance of this observation. PMID: 19923799 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 17, 2009 Category: Urology & Nephrology Authors: Shihab FS, Bennett WM, Andoh TF Tags: Am J Nephrol Source Type: journals

The Technical and Anatomical Aspects of the World's First Near-Total Human Face and Maxilla Transplant [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Successful near-total face and maxilla allograft transplant can be accomplished based on the facial arterial system and its arcades. This presents a novel method for reconstructing massive facial injuries with significant involvement of the facial skeleton. (Source: Archives of Facial Plastic Surgery)
Source: Archives of Facial Plastic Surgery - November 16, 2009 Category: Cosmetic Surgery Authors: Alam, D. S., Papay, F., Djohan, R., Bernard, S., Lohman, R., Gordon, C. R., Hendrickson, M., Siemionow, M. Tags: Otolaryngology/ Head & Neck Surgery, Surgery, Surgical Interventions, Surgical Interventions, Other, Surgical Physiology, Surgical Physiology, Other, Transplantation, Transplantation, Other, Facial Plastic Surgery, Reconstructive Facial Surgery, Trauma/ M Source Type: journals

Immune tolerance induction by integrating innate and adaptive immune regulators.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A diversity of immune tolerance mechanisms have evolved to protect normal tissues from immune damage. Immune regulatory cells are critical contributors to peripheral tolerance. These regulatory cells, exemplified by the CD4Foxp3 regulatory T (Treg) cells and a recently identified population named myeloid-derived suppressor cells (MDSCs), regulate immune responses and limiting immune-mediated pathology. In a chronic inflammatory setting, such as allograft-directed immunity, there may be a dynamic "crosstalk" between the innate and adaptive immunomodulatory mechanisms for an integrated control of immune damage. CTLA4-B7-...
Source: Cell Transplantation - November 16, 2009 Category: Cytology Authors: Suzuki J, Ricordi C, Chen Z Tags: Cell Transplant Source Type: journals

Peroneal nerve damage by bicortical tibial screw in ACL reconstructionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Arthroscopically assisted anterior cruciate ligament reconstruction is regarded as a minimally invasive surgery with low morbidity but complications still occur. Reports of neurovascular injuries related to graft harvesting, tunnel placement, or graft fixation are limited. A rare case of peroneal nerve injury related to hardware used for graft fixation in the tibial in a 28-year-old female patient who underwent an anterior cruciate ligament reconstruction surgery using a patellar tendon graft (bone-tendon-bone graft) is presented. Post-operatively, the patient presented with clinical signs of perone...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - November 14, 2009 Category: Orthopaedics Tags: Knee Surgery, Sports Traumatology, Arthroscopy Source Type: journals

ACL prosthesis: any promise for the future?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides a review of the history of the use of prosthetics with respect to ACL reconstruction grafts including Carbon Fibre, Gore-Tex and Dacron prosthetics, as well as the Leeds-Keio Artificial Ligament and the Kennedy Ligament Augmentation Device (LAD). Emphasis is placed on the ligament advanced reinforcement system (LARS) as preliminary investigations of its use have been encouraging. Significant progress has been made recently with respect to the understanding of ACL anatomy, composition, biomechanics, and healing processes, leading to innovative techniques using approaches based in tissue engineerin...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - November 14, 2009 Category: Orthopaedics Tags: Knee Surgery, Sports Traumatology, Arthroscopy Source Type: journals

Polyglactin Mesh Less Costly Than Aceullar Dermal Allograft for Breast ReconstructionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Polyglactin mesh yields similar results in breast reconstruction surgery, at one twelfth the cost. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 13, 2009 Category: Consumer Health News Tags: Plastic Surgery & Aesthetic Medicine Source Type: news

Ultrastructural alterations in endothelial mitochondria are associated with enhanced nitrotyrosine accumulation and progressive reduction of VEGF expression in sequential protocol renal allograft biopsies with calcineurin inhibitor toxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study shows a relatively high incidence of CNIT in protocol renal allograft biopsies, indicating that this might be an important mechanism of background damage to the allograft. Structural alterations in endothelial mitochondria are consistent findings in protocol biopsies with CNIT and this relatively specific mitochondrial damage may stem from the peroxynitrite-mediated damage associated with progressive loss of protective function of VEGF. (Source: Transplant International)
Source: Transplant International - November 13, 2009 Category: Transplant Surgery Authors: Alok Sharma, Sumeet Jain, Ruchika Gupta, Kishore Gopal Banerjee, Sandeep Guleria, Sanjay Kumar Agarwal, Amit Kumar Dinda Source Type: journals

[Preserving foot surgery for diabetics.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The reconstruction of a diabetic foot is still a challenge for the orthopedic surgeon. Untreated fractures, dislocations and foot and ankle deformities with consequent ulcerations may increase the risk of limb amputation. For patients who refuse a major amputation a surgical reconstruction can be started using bone grafts, angle stable locking plates and ankle arthrodesis nails. The goal of reconstruction in all patients is to avoid amputation. PMID: 19908026 [PubMed - as supplied by publisher] (Source: Der Orthopade)
Source: Der Orthopade - November 13, 2009 Category: Orthopaedics Authors: Müller S, Wenz W Tags: Orthopade Source Type: journals

A case of recurrent type 1 diabetes mellitus with insulitis of transplanted pancreas in simultaneous pancreas–kidney transplantation from cardiac death donorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions/interpretation The histological features of insulitis in transplanted pancreas were consistent with common type 1 diabetes mellitus, but the clinical course of the recurrence appeared to be more rapid. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00125-009-1593-3Authors M. Ishida-Oku, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences Maidashi 3-1-1, Higashi-ku Fukuoka 812-8582 JapanM. Iwase, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences Maidashi 3-1-1, Higashi-ku Fuk...
Source: Diabetologia - November 12, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals

Biomarkers for early and late stage chronic allograft nephropathy by proteogenomic profiling of peripheral blood.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study identifies several unique signatures of transcript and protein biomarkers with high predictive accuracies for mild and moderate/severe CAN, the most common cause of late allograft failure. These biomarkers are the necessary first step to a proteogenomic classification of CAN based on peripheral blood profiling and will be the targets of a prospective clinical validation study. PMID: 19593431 [PubMed - indexed for MEDLINE] (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 12, 2009 Category: Genetics & Stem Cells Authors: Kurian SM, Heilman R, Mondala TS, Nakorchevsky A, Hewel JA, Campbell D, Robison EH, Wang L, Lin W, Gaber L, Solez K, Shidban H, Mendez R, Schaffer RL, Fisher JS, Flechner SM, Head SR, Horvath S, Yates JR, Marsh CL, Salomon DR Tags: PLoS One Source Type: journals

Plasma cell infiltrates in polyomavirus nephropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Polyomavirus (PV) associated nephropathy (PVAN) has become an important cause of allograft dysfunction. We studied plasma cells (PCs) [ndash] which have not yet been characterized [ndash] present in the cellular infiltrate of 20 PVAN cases using immunohistochemistry and morphometry. The results were correlated with morphological, clinical and anti-BK virus serological findings. PC-rich cellular infiltrates occurred in 50% of cases (>15% PCs in the cellular infiltrate) and in these IgM producing PCs were commonly seen (70%): IgM PC predominance in 50% of cases and a comparable number of IgM and IgG PCs in 20% of cases. We f...
Source: Transplant International - November 12, 2009 Category: Transplant Surgery Authors: Éva Kemény, Hans H. Hirsch, József Eller, Ursula Dürmüller, Helmut Hopfer, Michael J. Mihatsch Source Type: journals

From stem cells and cadaveric matrix to engineered organs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The definitive treatment for end-stage heart failure, organ transplant, is limited by the supply of donor organs. Successful allograft recipients suffer significant adverse effects from chronic antirejection medications. Positive clinical treatment of injured myocardium with stem/progenitor cells has led to hope that one day autologous stem-cell-derived whole or partial donor organs can be generated. Advances in the ability to isolate (or generate) stem or progenitor cells that can give rise to beating cardiocyte-like cells and vascular components, and the advent of human iPS cell technology when combined with recent a...
Source: Current Opinion in Biotechnology - November 12, 2009 Category: Biotechnology Authors: Taylor DA Tags: Curr Opin Biotechnol Source Type: journals

Advanced glycation end products enhance monocyte activation during human mixed lymphocyte reaction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Posttransplant diabetes mellitus (PTDM) is a frequent complication among transplant recipients. Ligation of advanced glycation end products (AGEs) with their receptor (RAGE) on monocytes/macrophages plays roles in the diabetes complications. The enhancement of adhesion molecule expression on monocytes/macrophages activates T-cells, leading to reduced allograft survival. We investigated the effect of four distinct AGE subtypes (AGE-2/AGE-3/AGE-4/AGE-5) on the expressions of intracellular adhesion molecule (ICAM)-1, B7.1, B7.2 and CD40 on monocytes, the production of interferon (IFN)-gamma and tumor necrosis factor (TNF)...
Source: Clinical Immunology - November 12, 2009 Category: Allergy & Immunology Authors: Ohashi K, Takahashi HK, Mori S, Liu K, Wake H, Sadamori H, Matsuda H, Yagi T, Yoshino T, Nishibori M, Tanaka N Tags: Clin Immunol Source Type: journals

Osteotome Sinus Floor Elevation without Bone Grafts – A 3-Year Retrospective Study with Astra Tech ImplantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The OSFE technique, without bone grafts, was found to produce predictable results in the treatment of 36 patients with restricted bone volume in the posterior part of the maxilla. (Source: Clinical Implant Dentistry and Related Research)
Source: Clinical Implant Dentistry and Related Research - November 10, 2009 Category: Dentistry Authors: Robert Fermergård, Per Åstrand Source Type: journals

Osteotomy of distal radius fracture malunion using a fast remodeling bone substitute consisting of calcium sulphate and calcium phosphate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study a novel fast resorbing biphasic bone substitute consisting of a mixture of calcium sulphate and calcium phosphate is used (Cerament BoneSupport AB, Sweden). Fifteen consecutive patients, with a mean age of 52 (27-71) years were included. All had a malunion after a distal radius fracture and underwent an osteotomy. A fragment specific fixation system, TriMed(R) (TriMed, Valencia, CA), consisting of a Buttress Pin(R) and a Radial Pin Plate(R) were used for fixation and a calcium sulphate and calcium phosphate mixture as bone substitute. The patients were followed for 1 year. Grip strength increased from 61 (28-...
Source: Biomed Res - November 10, 2009 Category: Research Authors: Abramo A, Geijer M, Kopylov P, Tägil M Tags: J Biomed Mater Res B Appl Biomater Source Type: journals

The significance of C4d staining with minimal histologic abnormalities.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PURPOSE OF REVIEW: C4d deposition within peritubular capillaries (PTCs) in renal allograft biopsies is a specific marker for interaction of antibody with the graft, and is an extremely useful tool for the diagnosis of antibody-mediated rejection (AMR). Whereas PTC C4d itself is not diagnostic of AMR, it is usually accompanied by histologic features of acute and/or chronic AMR. However, some biopsies, mainly from ABO-incompatible renal allografts, show C4d staining without histologic findings of AMR or cell-mediated rejection. The significance of such C4d staining remains a topic of debate, and this finding may have dif...
Source: Current Opinion in Organ Transplantation - November 10, 2009 Category: Transplant Surgery Authors: Haas M Tags: Curr Opin Organ Transplant Source Type: journals

Long-term Outcomes of Keratolimbal Allograft for Total Limbal Stem Cell Deficiency Using Combined Immunosuppressive Agents and Correction of Ocular Surface Deficits [Clinical Sciences]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Correction of ocular surface deficits combined with an immunosuppressive regimen further improves the long-term outcome of KLAL in eyes with total limbal stem cell deficiency. (Source: Archives of Opthalmology)
Source: Archives of Opthalmology - November 9, 2009 Category: Opthalmology Authors: Liang, L., Sheha, H., Tseng, S. C. G. Tags: Ophthalmology, Ophthalmological Disorders, Corneal Disorders, Ophthalmological Procedures, Ophthalmological Procedures, Other, Transplantation, Transplantation, Other, Drug Therapy, Drug Therapy, Other, Immunology, Immunology, Other Clinical Sciences Source Type: journals

In situ surgical procedures for locally advanced pancreatic cancer: partial abdominal evisceration and intestinal autotransplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We were able to perform in situ procedures including partial abdominal evisceration and intestinal autotransplantation for two cases of pancreatic cancer with possible invasion to the root of the mesentery. There are few reports of such procedures. There has been one report of a case which applied an ex vivo technique. It is expected that the development of adequate adjuvant therapy will lead to further improvement in the prognosis of pancreatic cancers. Content Type Journal ArticleCategory Surgeon at workDOI 10.1007/s00534-009-0188-1Authors Hodaka Amano, Teikyo University School of Medic...
Source: Journal of Hepato-Biliary-Pancreatic Surgery - November 9, 2009 Category: Surgery Tags: Journal of Hepato-Biliary-Pancreatic Surgery Source Type: journals

Benefits of PRP and PRGF: Does the Clinical Experience Support the Literature?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I have read about PRP and PRGF and have attended lectures on the subject. It seems like the literature establishes a strong case for the benefits of using these in bone grafts to enhance regeneration and healing. >>Read More and Comment (Source: Dental Implants Discussed by Experts)
Source: Dental Implants Discussed by Experts - November 9, 2009 Category: Dentistry Authors: osseonews Tags: bone grafting en Regenerative Products Source Type: info

AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We reported earlier on the oncogenic properties of Grm1 by demonstrating that stable Grm1-mouse-melanocytic clones proliferate in the absence of growth supplement and anchorage in vitro. In addition, these clones also exhibit aggressive tumorigenic phenotypes in vivo with short latency in tumor formation in both immunodeficient and syngeneic mice. We also detected strong activation of AKT in allograft tumors specifically AKT2 as the predominant isoform involved. In parallel, we assessed several human melanoma biopsy samples and found again that AKT2 was the predominantly activated AKT in these human melanoma biopsies. In c...
Source: Pigment Cell Research - November 9, 2009 Category: Cytology Authors: Seung-Shick Shin, Brian A. Wall, James S. Goydos, Suzie Chen Source Type: journals

Impact of glucose metabolism abnormalities on histopathological changes in kidney transplant protocol biopsiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the association of glucose metabolism abnormalities on the progression of histopathological changes in serial protocol biopsies. Helsinki University Hospital kidney transplant recipients during 2004[ndash]2006 were followed up. Patients with pre-existing diabetes or 2-h oral glucose tolerance test (OGTT) performed at 3 months, and protocol biopsies taken at 0 and 12 months were analyzed (n = 76). Diabetes was defined according to WHO/ADA. Histology was analyzed with chronic allograft damage index (CADI). Altogether 32 patients had pre-existing diabetes. In OGTT at 3 months, four showed PTDM, eight impaired gluc...
Source: Transplant International - November 9, 2009 Category: Transplant Surgery Authors: Ilkka Helanterä, Fernanda Ortiz, Anne Räisänen-Sokolowski, Petri Koskinen Source Type: journals