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Systolic function of patients with myocardial infarction undergoing autologous bone marrow transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Autologous mononuclear bone marrow cell transplantation did not improve the echocardiographic parameters of systolic function. (Source: Arquivos Brasileiros de Cardiologia)
Source: Arquivos Brasileiros de Cardiologia - November 20, 2009 Category: Cardiology Source Type: journals

Hyperlipidemic myeloma: review of 53 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the clinical characteristics, the therapeutic options, and the pathophysiologic mechanisms of hyperlipidemic myeloma are comprehensively reported using the available data from all 53 published cases in the literature. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0849-9Authors Benjamin Misselwitz, University Hospital Zürich Department of Internal Medicine Rämistr. 100 8091 Zürich SwitzerlandJeroen S. Goede, University Hospital Zürich Clinic of Haematology Rämistr. 100 8091 Zürich SwitzerlandBernhard C. Pestalozzi, University Hospital Zürich Clinic of Oncology Rämi...
Source: Annals of Hematology - November 18, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals

Stem Cells May Improve Heart Bypass ResultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients who had bone marrow transplant with surgery did better, study finds Source: HealthDay Related MedlinePlus Topics: Coronary Artery Bypass Surgery, Stem Cells (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - November 17, 2009 Category: Consumer Health News Source Type: consumer

Bone marrow transplant for severe combined immunodeficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this issue of The Journal, Railey et al report a quarter-century experience at Duke University Medical Center and the long-term outcome of non-ablative bone marrow transplantation for severe combined immunodeficiency (SCID) in a cohort of 161 infants who had related, predominantly non-identical, donors. Outcome at 6 months to 27 years follow-up (mean 8.7 years) showed 77% survival. Critical determinant of survival was early transplant at (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 16, 2009 Category: Pediatrics Authors: Sarah S. Long Tags: The Editors' Perspectives Source Type: journals

Cord blood and bone marrow transplantation in inherited metabolic diseases: scientific basis, current status and future directionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Progressive degeneration of the central nervous system leading to the loss of neuromotor, neurophysiological and cognitive abilities is the fundamental clinical problem in patients with many inherited metabolic diseases (IMD). Worldwide experience shows that morbidity, quality of life, and survival in these patients can be improved by allogeneic haematopoietic stem cell transplantation (HSCT), particularly when performed early in the course of the disease. At present, while available for some conditions, exogenous enzyme replacement therapy is unable to correct cognitive and central nervous system disease because of its in...
Source: British Journal of Haematology - November 16, 2009 Category: Hematology Authors: Vinod K. Prasad, Joanne Kurtzberg Source Type: journals

Severe oral mucositis associated with cancer therapy: impact on oral functional status and quality of lifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Severe OM can cause profound pain and oral functional incapability and clinical significant impairment of QoL. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00520-009-0771-7Authors Karis Kin-Fong Cheng, The Chinese University of Hong Kong Faculty of Medicine, The Nethersole School of Nursing Room732, Esther Lee Building, Sha Tin Hong Kong N.T. ChinaS. F. Leung, Prince of Wales Hospital Department of Clinical Oncology Hong Kong N.T. ChinaRaymond H. S. Liang, The University of Hong Kong Division of Hematology, Medical Oncology and Bone Marrow transplantation, Faculty of Med...
Source: Supportive Care in Cancer - November 14, 2009 Category: Cancer & Oncology Tags: Supportive Care in Cancer Source Type: journals

Successful bone marrow transplantation in chronic granulomatous diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pediatrics International)
Source: Pediatrics International - November 13, 2009 Category: Pediatrics Authors: Mizuka Miki, Atsushi Ono, Ayumi Awaya, Shinichiro Miyagawa, Rie Onodera, Emi Kurita, Asako Hiraoka, Fumio Hidaka, Tomoyuki Mizukami, Hiroyuki Nunoi, Masao Kobayashi Tags: PATIENT REPORTS Source Type: journals

Recombinant human bone morphogenetic protein-7 enhances fracture healing in an ischemic environmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our results indicate that rhBMP7 is a promising treatment for fractures with severely disrupted blood supply. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res (Source: Journal of Orthopaedic Research)
Source: Journal of Orthopaedic Research - November 13, 2009 Category: Orthopaedics Authors: Chuanyong Lu, Zhiqing Xing, Yan-yiu Yu, Celine Colnot, Theodore Miclau, Ralph S. Marcucio Source Type: journals

Response of refractory immune thrombocytopenia after bone marrow transplantation to romiplostimEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Jill C. Beck, Michael J. Burke, Jakub Tolar Source Type: journals

Targeting PKC-theta Protein: A Way To Inhibit Harmful Immune Responses?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For some individuals with leukemia, the best treatment option is to receive a bone marrow transplant from a person who is not an identical genetic match. The donor bone marrow gives rise to immune cells that attack the leukemia (a response known as a graft-versus leukemia [GVL] response). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 10, 2009 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news

Targeting PKC-theta Protein: A Way To Inhibit Harmful Immune Responses?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For some individuals with leukemia, the best treatment option is to receive a bone marrow transplant from a person who is not an identical genetic match. The donor bone marrow gives rise to immune cells that attack the leukemia (a response known as a graft-versus leukemia [GVL] response). In some cases, however, the immune cells generated by the donor bone marrow attack other cells in the patient's body and this highly toxic response is known as graft-versus-host disease (GVHD). (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 10, 2009 Category: Allergy & Immunology Tags: Lymphoma / Leukemia / Myeloma Source Type: news

SMC accepts use of bortezomib (Velcade®) as mono-therapy for progressive multiple myeloma in NHSScotlandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Scottish Medicines Consortium (SMC) Area: Evidence > Drug Specific Reviews The Scottish Medicines Consortium (SMC) has accepted for use within NHSScotland, bortezomib (Velcade®) as mono-therapy for the treatment of progressive multiple myeloma in patients who have received at least one prior therapy and who have already undergone or are unsuitable for bone marrow transplantation. This SMC advice takes account of the benefits of a Patient Access Scheme (PAS) that improves the cost-effectiveness of bortezomib and this advice is contingent upon the continuing availability of the PAS in NHSScotland. (Source: NeLM - Oncology)
Source: NeLM - Oncology - November 10, 2009 Category: Cancer & Oncology Source Type: organizations

SMC accepts use of filgrastim (Ratiograstim®) in NHSScotlandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Scottish Medicines Consortium (SMC) Area: Evidence > Drug Specific Reviews The Scottish Medicines Consortium (SMC) has accepted for use within NHSScotland filgrastim (Ratiograstim) for the following licensed indications: 1. Reduction in the duration of neutropenia and the incidence of febrile neutropenia (FN) in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes). 2. Reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation con...
Source: NeLM - Haematology - November 10, 2009 Category: Hematology Source Type: organizations

Lorenzo's oil disease gene trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This research indicates the potential of gene therapy in ALD. The study is important as, although the disease is rare, its effects are serious and fatal if not treated. The boys have been followed for about 30 months and the longer-term effects of the treatment are not yet clear. As the authors note, larger studies with longer follow-up are needed to determine the longer-term effects of this treatment and any risks associated with it. Further studies are also needed to determine how well the therapy compares to stem-cell transplant in boys who have a matched donor. Links To The Headlines Gene therapy could cure...
Source: NHS News Feed - November 9, 2009 Category: Consumer Health News Tags: Genetics/stem cells Source Type: news

Cutaneous T-cell lymphoma (mycosis fungoides) relapsed with different immunological phenotype after bone marrow transplantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 9, 2009 Category: Dermatology Authors: S. Okada, Y. Nannya, S. Ota, Y. Takazawa, G. Yamamoto, K. Kumano, K. Izutsu, T. Takahashi, S. Chiba, M. Kurokawa Source Type: journals

Narrowband ultraviolet B phototherapy in the treatment of cutaneous graft-versus-host disease in oncohaematological paediatric patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This study provides evidence that NB-UVB phototherapy represents a valid second-line treatment in paediatric patients affected by GVHD and refractory to immunosuppressive first-line treatment. PMID: 19903177 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 9, 2009 Category: Dermatology Authors: Brazzelli V, Grasso V, Muzio F, Moggio E, Zecca M, Locatelli F, Borroni G Tags: Br J Dermatol Source Type: journals

Cutaneous T-cell lymphoma (mycosis fungoides) relapsed with different immunological phenotype after bone marrow transplant.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19903173 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 9, 2009 Category: Dermatology Authors: Okada S, Nannya Y, Ota S, Takazawa Y, Yamamoto G, Kumano K, Izutsu K, Takahashi T, Chiba S, Kurokawa M Tags: Br J Dermatol Source Type: journals

Boy beats phobia to save life of sick sisterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A SCHOOLBOY has overcome his phobia of needles to give his older sister a lifesaving bone marrow transplant. (Source: Scotsman.com News - Health)
Source: Scotsman.com News - Health - November 8, 2009 Category: Consumer Health News Source Type: news

Cooley's Anemia Foundation 2010-2011 Research FellowshipsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Cooley's Anemia Foundation invites national and international applications for 2010-2011 Research Fellowships. Postdoctoral and junior faculty members investigating clinical or basic research related to thalassemia are eligible. Applications studying iron overload, iron chelation, methods of non-invasive iron measurement, quality of life, hepatitis C, osteoporosis, fertility, bone marrow transplantation and gene therapy are encouraged. Postdoctoral fellows should hold MD, PhD or equivalent degrees and require sponsorship by a faculty mentor. Junior faculty applicants should not have held the rank of Assistant Professo...
Source: ScanGrants feed - November 8, 2009 Category: Research Authors: Cooley's Anemia Foundation Source Type: funding

Update on invasive opportunistic mycoses: Clinical trials review, 2008–2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article summarizes five of the most relevant clinical trials related to prevention and treatment of opportunistic fungal infections in adult patients published between 2008 and 2009. Content Type Journal ArticleDOI 10.1007/s11908-009-0060-0Authors Andreas H. Groll, Children’s University Hospital Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology/Oncology Albert-Schweitzer-Strasse 33 48129 Münster Germany Journal Current Infectious Disease ReportsOnline ISSN 1534-3146Print ISSN 1523-3847 Journal Volume Volume 11 Journal Issue Volume...
Source: Current Infectious Disease Reports - November 5, 2009 Category: Infectious Diseases Tags: Current Infectious Disease Reports Source Type: journals

Obituary: Humphrey KayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Haematologist with a radical approach to leukaemia treatmentHumphrey Kay, who has died aged 86, was an early pioneer in the scientific approach to the diagnosis and treatment of leukaemia. When Humphrey joined the Royal Marsden hospital in London as a consultant in haematology in 1956, leukaemia, or cancer of the blood, was usually fatal within weeks. With characteristic insight, he set about instituting a collaborative approach to treatment, combining practical strategies with scientific method. From these beginnings, the treatment of leukaemia went on to become one of science's great success stories of the 20th cent...
Source: Guardian Unlimited Science - November 5, 2009 Category: Science Tags: Cancer Medical research People in science The Guardian Obituaries Source Type: news

Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent reports describe hematopoietic abnormalities in mice with targeted instability of the mitochondrial genome. However, these abnormalities have not been fully described. We demonstrate that mutant animals develop an age-dependent, macrocytic anemia with abnormal erythroid maturation and megaloblastic changes, as well as profound defects in lymphopoiesis. Mice die of severe fatal anemia at 15 months of age. Bone-marrow transplantation studies demonstrate that these abnormalities are intrinsic to the hematopoietic compartment and dependent upon the age of donor hematopoietic stem cells. These abnormalities are phenotypi...
Source: Blood - November 5, 2009 Category: Hematology Authors: Chen, M. L., Logan, T. D., Hochberg, M. L., Shelat, S. G., Yu, X., Wilding, G. E., Tan, W., Kujoth, G. C., Prolla, T. A., Selak, M. A., Kundu, M., Carroll, M., Thompson, J. E. Tags: Hematopoiesis and Stem Cells Source Type: journals

Very Early Bone Marrow Transplant Best for Severe Combined ImmunodeficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Most infants with severe combined immunodeficiency (SCID) do well with related donor marrow transplants, researchers report. However, those transplanted in the first few months of life tend to have even better survival rates, fewer clinical problems, less need for booster transplants, and better nutritional status. Reuters Health Information (Source: Medscape Pediatrics Headlines)
Source: Medscape Pediatrics Headlines - November 5, 2009 Category: Pediatrics Tags: Pediatrics Source Type: info

Epithelial Mesenchymal Transition in Human Ocular Chronic Graft-Versus-Host Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we used immunohistochemistry and electron microscopy to investigate whether epithelial mesenchymal transition (EMT) contributed to the pathogenesis of ocular cGVHD. We detected down-regulation of E-cadherin and translocation of beta-catenin from the intercellular junction to the cytoplasm and nucleus of cGVHD conjunctival basal epithelia and lacrimal gland myoepithelia. Notable findings included expression of Snail, an inducer of EMT, in the nucleus of ocular cGVHD epithelia. The fibrosis markers heat shock protein 47, alpha-smooth muscle actin, and fibroblast specific protein-1 were overexpressed in ocular ...
Source: The American Journal of Pathology - November 5, 2009 Category: Pathology Authors: Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K Tags: Am J Pathol Source Type: journals

Immune Therapy Can Protect Against Or Treat Later LymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Specially developed immune system cells that target the common Epstein-Barr virus can protect immune-suppressed bone marrow transplant recipients against lymph system disease and cancers that arise from the viral infection, said a group of researchers led by those from Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 3, 2009 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news

StemEx(R) Noted As A Reliable Investigational Product Of An Expanded Population Of Stem Cells At Umbilical Cord Blood Symposium In IsraelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
At a symposium today in Herzliya entitled Umbilical Cord Blood: An Alternative for Bone Marrow Transplantation in Adults, bone marrow transplantation experts Professor Patrick Stiff and Professor Guillermo Sanz addressed participants on the current challenges presented by bone marrow transplantation (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 3, 2009 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

Nigeria: UPTH to Treat Bone Marrow, Renal Failure Cases - MDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sick Nigerians who desire bone marrow transplant and those with renal failure could now be treated at the University of Port Harcourt Teaching Hospital (UPTH), outgoing Chief Medical Director, Dr. Uriel S. Etawo, has said. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 2, 2009 Category: African Health Source Type: news

Immune therapy can protect against or treat later lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Baylor College of Medicine) Specially developed immune system cells that target the common Epstein-Barr virus can protect immune-suppressed bone marrow transplant recipients against lymph system disease and cancers that arise from the viral infection, said a group of researchers led by those from Baylor College of Medicine, the Methodist Hospital and Texas Children's Hospital. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 2, 2009 Category: Global & Universal Source Type: news

Immune therapy can protect against or treat later lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Specially developed immune system cells that target the common Epstein-Barr virus can protect immune-suppressed bone marrow transplant recipients against lymph system disease and cancers that arise from the viral infection, said a group of researchers led by those from Baylor College of Medicine , The Methodist Hospital and Texas Children's Hospital. "Therapy with EBV-specific CTLs (cytotoxic lymphocytes) was effective for these patients who were severely immune-compromised, as the cells successfully reached the tumor, multiplied and were able to kill tumor cells," said Dr. Helen Heslop, lead author of the study,...
Source: Baylor College of Medicine News - November 2, 2009 Category: Universities & Medical Training Source Type: news

Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic low-grade inflammation, particularly in adipose tissue, is an important modulator of obesity-induced insulin resistance. The Toll-like receptor 4 (Tlr4) is a key initiator of inflammatory responses in macrophages. We performed bone marrow transplantation (BMT) of Tlr4lps-del or control C57Bl/10J donor cells into irradiated wild-type C57Bl6 recipient mice to generate hematopoietic cell-specific Tlr4 deletion mutant (BMT-Tlr4(-/-)) and control (BMT-WT) mice. After 16 weeks of a high-fat diet (HFD), BMT-WT mice developed obesity, hyperinsulinemia, glucose intolerance, and insulin resistance. In contrast, BMT-Tlr4(...
Source: Cell Metabolism - November 1, 2009 Category: Cytology Authors: Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, Bandyopadhyay G, Verma IM, Olefsky JM Tags: Cell Metab Source Type: journals

Hematopoietic stem cell transplantation nursing: a practice variation study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although published standards are under consideration, practice variation exists across transplantation centers. Whether the variation is caused by a lack of compliance with published guidelines or by the poor delineation of details for providers to translate the guidelines into practice is not known. INTERPRETATION: Identifying gaps in the literature and inconsistencies in HSCT practices is an important first step in designing evidence-based projects that can be used to standardize practice and link best practices to improved patient outcomes. PMID: 19887345 [PubMed - in process] (Source: Oncology Nursing Forum)
Source: Oncology Nursing Forum - November 1, 2009 Category: Nursing Authors: Bevans M, Tierney DK, Bruch C, Burgunder M, Castro K, Ford R, Miller M, Rome S, Schmit-Pokorny K Tags: Oncol Nurs Forum Source Type: journals

Rehabilitation of exacerbated case of oral mucositis associated with renal failure following bone marrow transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pavesi VCS, Martins MAT, Seneda L M, Massumoto C, Fernandes KPS, Bussadori S K, Martins M DIndian Journal of Dental Research 2009 20(3):365-369Inflammation of oral mucosa induced by anti neoplastic drugs is an important, dose limiting and costly side effect of cancer therapy. Here is presented an exacerbated case of oral mucositis associated with renal failure in a patient who underwent bone marrow transplantation. The clinical aspects and an integrated rehabilitation program are discussed below. (Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3))
Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3) - October 31, 2009 Category: Dentistry Authors: Pavesi VCS, Martins MAT, Seneda L M, Massumoto C, Fernandes KPS, Bussadori S K, Martins M D Source Type: journals

Fibrocytes are associated with vascular and parenchymal remodelling in patients with obliterative bronchiolitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results indicate that fibrocytes are associated with pathological remodelling processes in patients with obliterative bronchiolitis and that tissue fibrocytes might be a possible useful biomarker in these processes. (Source: Respiratory Research)
Source: Respiratory Research - October 30, 2009 Category: Respiratory Medicine Authors: Annika Andersson-SjolandJonas ErjefaltLeif BjermerLeif ErikssonGunilla Westergren-Thorsson Source Type: journals

Plasmacytoid Dendritic Cells: Physiologic Roles and Pathologic StatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Plasmacytoid dendritic cells (PDCs) have perplexed pathologists for decades, undergoing multiple adjustments in nomenclature as their lineage and functions have been characterized. Although PDCs account for less than 0.1% of peripheral blood mononuclear cells, they serve as a principal source of interferon-[alpha] and are also known as interferon-I producing cells (IPCs). Upon activation in vitro, they can differentiate into dendritic cells, and recent studies have substantiated a potential role in antigen presentation. Thus, PDCs may act as a link between innate and adaptive immunity. Normally found in small quantities in...
Source: Advances in Anatomic Pathology - October 29, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Pre-transplant lung function is predictive of survival following pediatric bone marrow transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary toxicity is well described in recipients of bone marrow transplants (BMT), and accounts for a sizeable proportion of post-transplant mortality. The majority of the data on post-transplant pulmonary function is from adults, although several small pediatric case series have been described. In adults, pre-transplant lung function has been predictive of post-transplant respiratory failure and mortality. This use of pulmonary function testing, that is, for pre-transplant risk counseling, is novel but has never been applied to pediatric patients. We hypothesized that in children, as in adults, pre-transplant pulmonary ...
Source: Pediatric Blood and Cancer - October 29, 2009 Category: Cancer & Oncology Authors: Jill P. Ginsberg, Richard Aplenc, Joseph McDonough, James Bethel, John Doyle, Daniel J. Weiner Source Type: journals

Autologous stem cell transplantation in myeloma: the St James’s Hospital experience, 1997–2003Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Centre outcome is comparable to published international series and supports the use of ASCT in the treatment of this malignancy. Content Type Journal ArticleCategory Original PapersDOI 10.1007/BF03169125Authors P. J. Hayden, St James’s Hospital Dept. of Haematology Dublin 8A. O’Driscoll, St James’s Hospital Dept. of Haematology Dublin 8N. Gardiner, St James’s Hospital Dept. of Haematology Dublin 8R. Swords, Beaumont Hospital Dept of Haematology Dublin 9J. Sargent, Mid-West Regional Hospital Dept. of Haematology Dooradoyle Co. LimerickF. Ni Ainle, Waterford Regional Hospital Dept. of H...
Source: Irish Journal of Medical Science - October 28, 2009 Category: Journals (General) Tags: Irish Journal of Medical Science Source Type: journals

Left ventricular aneurysm in a child with severe combined immunodeficiency syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the case of a 23-month-old girl with combined immunodeficiency syndrome and a left ventricular aneurysm. Due to the size of the aneurysm and development of an intramural thrombus, repair was performed after confirmation of bone marrow transplant engraftment. Endoventricular circular patch plasty (Dor procedure) was performed, with excellent outcome and normalization of ventricular geometry and function. PMID: 19853138 [PubMed - in process] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 27, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Jamshidi R, Hornberger LK, Karl TR Tags: Ann Thorac Surg Source Type: journals

Comparison on In Vitro Characterization of Fucospheres and Chitosan Microspheres Encapsulated Plasmid DNA (pGM-CSF): Formulation Design and Release Characteristics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the characterizations of the microspheres can be modulated by changing the formulation variables, and it can be concluded that fucospheres might be a potential carrier system for the controlled delivery of GM-CSF encoding plasmid DNA. PMID: 19859814 [PubMed - as supplied by publisher] (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - October 27, 2009 Category: Drugs & Pharmacology Authors: Demir Sezer A, Akbuğa J Tags: AAPS PharmSciTech Source Type: journals

Natural course of HCV infection in childhood cancer survivorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The outcome of hepatitis C in our patients is comparable to the one described in European cohorts of adult cancer survivors and perinatally infected subjects. Nevertheless, progression to high degrees of hepatic damage has to be monitored by a careful follow-up. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00520-009-0763-7Authors Francesca Fioredda, Giannina Gaslini Children’s Hospital Department of Pediatric Hematology, Oncology, and Bone Marrow Transplantation Largo Gerolamo Gaslini 5 16147 Genoa ItalyAndrea Moser, Medical University of Graz Division of Pediatric H...
Source: Supportive Care in Cancer - October 26, 2009 Category: Cancer & Oncology Tags: Supportive Care in Cancer Source Type: journals

Erratum to: Lenalidomide in patients with cisplatin-refractory and multiply relapsed germ cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00432-009-0697-yAuthors Karin Oechsle, University Medical Center Eppendorf Departments of Oncology, Hematology, Bone Marrow Transplantation and Pneumology Martinistr. 52 20246 Hamburg GermanyCarsten Bokemeyer, University Medical Center Eppendorf Departments of Oncology, Hematology, Bone Marrow Transplantation and Pneumology Martinistr. 52 20246 Hamburg GermanyFriedemann Honecker, University Medical Center Eppendorf Departments of Oncology, Hematology, Bone Marrow Transplantation and Pneumology Martinistr. 52 20246 Hamburg Germany Journal Journal of Cancer ...
Source: Journal of Cancer Research and Clinical Oncology - October 26, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Enhanced B cell activation in the absence of CD81Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CD81 is a component of the CD19/CD21 co-receptor complex in B cells. However, the role of CD81 in B cell activation has not been clearly elucidated. Here, we demonstrate that Cd81–/– B cells stimulated via their B cell receptor fluxed higher intracellular-free calcium ion along with increased phosphorylation of spleen tyrosine kinase and phospholipase gamma 2. Additionally, Cd81–/– B cells responded to toll like receptor 4 stimulation with increased nuclear factor-kappa B activation, cell proliferation and antibody secretion compared with wild-type B cells. Cd81–/– mice also mounted a si...
Source: International Immunology - October 26, 2009 Category: Allergy & Immunology Authors: Sanyal, M., Fernandez, R., Levy, S. Tags: ORIGINAL RESEARCH PAPERS Source Type: journals

Management of relapse after allo-SCT for AML and the role of second transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& K Rezvani (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - October 26, 2009 Category: Hematology Authors: B N SavaniS MielkeN ReddyS GoodmanM JagasiaK Rezvani Source Type: journals

Viral-load and B-lymphocyte monitoring of EBV reactivation after allogeneic hemopoietic SCT in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
C Moroni & E Castagnola (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - October 26, 2009 Category: Hematology Authors: M FaraciI CavigliaG MorrealeE LaninoD CuzzubboS GiardinoE Di MarcoC CirilloF ScuderiS DallorsoP TerranovaC MoroniE Castagnola Source Type: journals

Autologous haematopoietic stem cell transplantation for secondary progressive multiple sclerosis: an exploratory cost-effectiveness analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
R Akehurst & J Snowden (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - October 26, 2009 Category: Hematology Authors: P TappendenR SaccardiC ConfavreuxB SharrackP A MuraroG L MancardiT KozakD Farge-BancelJ MadanR RafiaR AkehurstJ Snowden Source Type: journals

Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALLEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
S Kyrcz-Krzemien & J Holowiecki (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - October 26, 2009 Category: Hematology Authors: S GiebelB Stella-HolowieckaM Krawczyk-KulisN GökbugetD HoelzerM DoubekJ MayerB Piatkowska-JakubasA B SkotnickiH DombretJ M RiberaP P PiccalugaT CzerwS Kyrcz-KrzemienJ Holowiecki Source Type: journals

Achievement of complete donor-type chimerism and remission with dasatinib in Philadelphia chromosome-positive ALL relapsing after allogeneic transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
rliac & F L Dulley (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - October 26, 2009 Category: Hematology Authors: M ConchonS S SanabaniI BenditM SerpaU A FilhoP de Barros FerreiraM M Y NovaesR SaboyaP E Llacer-DorliacF L Dulley Source Type: journals

Acute cholecystitis caused by Haemophilus influenzae in a childEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A 6-year old girl was admitted to our hospital with high fever and right upper quadrant abdominal pain. At 5 years of age she had undergone allogeneic bone marrow transplantation because of intractable congenital pure red cell aplasia, after which she had asymptomatic cholelithiasis. Imaging studies and laboratory findings on admission suggested acute cholecystitis with a gallstone. The patient recovered completely after laparoscopic cholecystectomy was performed and was discharged on day 7 after the operation. Haemophilus influenzae grew on the aspirated purulent bile. It should be noted that H. in...
Source: Journal of Infection and Chemotherapy - October 24, 2009 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: journals

Recipient-derived HPA-1a antibodies: a cause of prolonged thrombocytopenia after unrelated donor stem cell transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: HPA-1a antibodies were associated with protracted PLT-transfusion dependence and significant hemorrhagic complications. Appropriate and timely laboratory investigation for HPA-specific antibodiesfollowed by transfusion support with HPA-selected PLTs provided the cornerstone of the hemostatic management in these cases. PMID: 19874563 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 23, 2009 Category: Hematology Authors: Lucas G, Culliford S, Green F, Sidra G, Calvert A, Green A, Harrison P, Harvey J, Allen D, Smillie D, Masurekar A, Marks D, Russell N, Massey E Tags: Transfusion Source Type: journals

Left Ventricular Aneurysm in a Child With Severe Combined Immunodeficiency Syndrome [CASE REPORTS]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the case of a 23-month-old girl with combined immunodeficiency syndrome and a left ventricular aneurysm. Due to the size of the aneurysm and development of an intramural thrombus, repair was performed after confirmation of bone marrow transplant engraftment. Endoventricular circular patch plasty (Dor procedure) was performed, with excellent outcome and normalization of ventricular geometry and function. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 22, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Jamshidi, R., Hornberger, L. K., Karl, T. R. Tags: Cardiac - other CASE REPORTS Source Type: journals

What is the role of bone marrow transplant in myeloma?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Edward Stadtmauer discusses the role of BMT in myeloma in his webcast, one of several from the Washington, DC Patient & Family Seminar (Source: International Myeloma Foundation)
Source: International Myeloma Foundation - October 22, 2009 Category: Hematology Source Type: organizations