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Secondary Tics or Tourettism Associated With a Brain TumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tourette syndrome is generally considered to be a genetic disorder, but symptoms mimicking Tourette syndrome can be secondary to an underlying lesion disrupting the basal ganglia circuitry. Described here is a case of secondary tics, or tourettism, in a child with a large oligodendroglioma of the right temporal lobe extending to the basal ganglia. He presented with attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and stimulant-induced tic disorder at the age of 11 years, and later also had also seizures. The family history was unremarkable. Cranial magnetic resonance imaging disclosed a right tempor...
Source: Pediatric Neurology - November 20, 2009 Category: Neurology Authors: Aimee F. Luat, Michael E. Behen, Csaba Juhász, Sandeep Sood, Harry T. Chugani Tags: Case Reports Source Type: journals

Assessment of 1p/19q status by fluorescence <i>in situ</i> hybridization assay: A comparative study in oligodendroglial, mixed oligoastrocytic and astrocytic tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion</b> : Loss of 1p/19q is strongly associated with oligodendroglial phenotype, while astrocytic tumors are more likely to show p53 over-expression. p53 expression and 1p/19q status appear to be mutually exclusive. (Source: Neurology India)
Source: Neurology India - November 20, 2009 Category: Neurology Authors: Shukla Bhaskar, Agarwal Shipra, Suri Vaishali, Pathak Pankaj, Sharma Mehar Chand, Gupta Deepak, Sharma Bhavani Shankar, Suri Ashish, Halder Ashutosh, Sarkar Chitra Source Type: journals

University College Hospital In London Introduces Treatments Delivering Faster Form Of RadiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two female brain tumor patients have become the first people in the south of England to be treated using a faster form of radiotherapy that extends more advanced care to more patients. RapidArc technology from Varian Medical Systems (NYSE: VAR) makes it possible to deliver image-guided IMRT (intensity modulated radiotherapy) two to eight times faster than is possible with conventional IMRT. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Radiology / Nuclear Medicine Source Type: news

University College Hospital In London Introduces Treatments Delivering Faster Form Of RadiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two female brain tumor patients have become the first people in the south of England to be treated using a faster form of radiotherapy that extends more advanced care to more patients. RapidArc technology from Varian Medical Systems (NYSE: VAR) makes it possible to deliver image-guided IMRT (intensity modulated radiotherapy) two to eight times faster than is possible with conventional IMRT. (Source: Radiology / Nuclear Medicine News From Medical News Today)
Source: Radiology / Nuclear Medicine News From Medical News Today - November 20, 2009 Category: Radiology Tags: Radiology / Nuclear Medicine Source Type: news

Cytotoxic Effects of Temozolomide and Radiation are Additive- and Schedule-DependentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: TMZ is not a radiosensitizing agent but yields additive cytotoxicity in combination with radiation. Our data indicate that TMZ treatment should commence at least 3 days before radiation to achieve maximum benefit. Activation of G2/M checkpoint signaling by TMZ and radiation has a cytoprotective effect that can be overcome by dual inhibition of ATM and ATR. More specific inhibition of checkpoint signaling will be required to increase treatment efficacy without exacerbating toxicity. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Anthony J. Chalmers, Elliot M. Ruff, Christine Martindale, Nadia Lovegrove, Susan C. Short Tags: Biology Contributions Source Type: journals

CIRM Awards Two $19 Million Grants for Brain Tumor ResearchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Of the 14 research teams to receive 4-year grants expected to result in clinical trials, two focus on brain tumor research. (Source: National Brain Tumor Society)
Source: National Brain Tumor Society - November 19, 2009 Category: Cancer & Oncology Source Type: organizations

Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
mp; Sebastian Brandner (Source: The EMBO Journal AOP)
Source: The EMBO Journal AOP - November 19, 2009 Category: Research Authors: Thomas S JacquesAlexander SwalesMonika J BrzozowskiNico V HenriquezJacqueline M LinehanZaman MirzadehCatherine O' MalleyHeike NaumannArturo Alvarez-BuyllaSebastian Brandner Tags: Article Source Type: journals

Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimuriumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that S. typhimurium A1-R monotherapy can effectively treat spinal cord glioma. (Source: Cell Proliferation)
Source: Cell Proliferation - November 19, 2009 Category: Cytology Authors: H. Kimura, L. Zhang, M. Zhao, K. Hayashi, H. Tsuchiya, K. Tomita, M. Bouvet, J. Wessels, R. M. Hoffman Source Type: journals

The novel ruthenium - [gamma]-linolenic complex [Ru2(aGLA)4Cl] inhibits C6 rat glioma cell proliferation and induces changes in mitochondrial membrane potential, increased reactive oxygen species generation and apoptosis in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present study reports the synthesis of a novel compound with the formula [Ru2(aGLA)4Cl] according to elemental analyses data, referred to as Ru2GLA. The electronic spectra of Ru2GLA is typical of a mixed valent diruthenium(II,III) carboxylate. Ru2GLA was synthesized with the aim of combining and possibly improving the anti-tumour properties of the two active components ruthenium and [gamma]-linolenic acid (GLA). The properties of Ru2GLA were tested in C6 rat glioma cells by analysing cell number, viability, lipid droplet formation, apoptosis, cell cycle distribution, mitochondrial membrane potential and reactive oxygen...
Source: Cell Biochemistry and Function - November 19, 2009 Category: Biochemistry Authors: Geise Ribeiro, Marcel Benadiba, Denise de Oliveira Silva, Alison Colquhoun Source Type: journals

Functional Modulation of Mitochondria by Eicosapentaenoic Acid Provides Protection against Ceramide Toxicity to C6 Glioma CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Agricultural and Food Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - November 18, 2009 Category: Food Science Tags: article Source Type: journals

World's First Delivery Of Intra-Arterial Avastin Directly Into Brain TumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neurosurgeons from NewYork-Presbyterian Hospital/Weill Cornell Medical Center performed the world's first intra-arterial cerebral infusion of Avastin (bevacizumab) directly into a patient's malignant brain tumor. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

World's First Delivery Of Intra-Arterial Avastin Directly Into Brain TumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neurosurgeons from NewYork-Presbyterian Hospital/Weill Cornell Medical Center performed the world's first intra-arterial cerebral infusion of Avastin (bevacizumab) directly into a patient's malignant brain tumor. This novel intra-arterial (IA) technique may expose the cancer to higher doses of the drug therapy, while possibly sparing the patient common side effects of receiving the drug intravenously (IV) or throughout their body. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 18, 2009 Category: Cancer & Oncology Tags: Neurology / Neuroscience Source Type: news

Cytotoxic, cytoprotective and antioxidant activities of resveratrol and analogues in C6 astroglioma cells in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Resveratrol (3,4',5-trans-trihydroxystilbene) and other hydroxystilbenes exhibit in vitro antioxidant as well as prooxidant effects. The antioxidant properties are assumed to enable these compounds to protect cells from oxidative damage. The prooxidant effects are held likely to be responsible for their cytotoxic, anti-proliferative or pro-apoptotic effects observed in vitro. Regarding antioxidant/prooxidant activities in the past various studies were performed aiming at defining structure-activity relationships for hydroxystilbenes using cell-free systems. In the present study cultured C6 glioma cells were used in ord...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Rüweler M, Gülden M, Maser E, Murias M, Seibert H Tags: Chem Biol Interact Source Type: journals

Patient Receives World's First Delivery Of Intra-arterial Avastin Directly Into A Malignant Brain TumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neurosurgeons from NewYork-Presbyterian Hospital/Weill Cornell Medical Center performed the world's first intra-arterial cerebral infusion of Avastin (bevacizumab) directly into a patient's malignant brain tumor. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Patient Receives World's First Delivery Of Intra-arterial Avastin Directly Into A Malignant Brain TumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neurosurgeons from NewYork-Presbyterian Hospital/Weill Cornell Medical Center performed the world's first intra-arterial cerebral infusion of Avastin (bevacizumab) directly into a patient's malignant brain tumor. This novel intra-arterial (IA) technique may expose the cancer to higher doses of the drug therapy, while possibly sparing the patient common side effects of receiving the drug intravenously (IV) or throughout their body. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 18, 2009 Category: Cancer & Oncology Tags: Cancer / Oncology Source Type: news

World's first delivery of intra-arterial Avastin directly into brain tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neurosurgeons have performed the world's first intra-arterial cerebral infusion of Avastin (bevacizumab) directly into a patient's malignant brain tumor. This novel technique may expose the cancer to higher doses of the drug therapy, while possibly sparing the patient common side effects of receiving the drug intravenously or throughout their body. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 18, 2009 Category: Science Source Type: news

A multidimensional examination of correlates of fatigue during radiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the current study was to investigate cancer-related fatigue in a radiotherapy sample using a multidimensional conceptualization to determine whether correlates of fatigue are consistent across all dimensions or whether each fatigue dimension has its own unique pattern of correlates.The study used a prospective cohort design with data collected from radiotherapy patients at 3 time points; before, after, and 6 weeks after radiotherapy treatment.A total of 210 participants were enrolled in the study. Results indicated the following relations. Increased general fatigue was found to be associated with lower per...
Source: Cancer - November 18, 2009 Category: Cancer & Oncology Authors: Amanda Purcell, Jennifer Fleming, Sally Bennett, Kathleen McGuane, Bryan Burmeister, Terry Haines Source Type: journals

Snail and Cox-2 expressions are associated with WHO tumor grade and survival rate of patients with gliomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, Snail and Cox-2 expressions were associated with WHO grade in gliomas and may be used as prognostic indicators. (Source: Neuropathology)
Source: Neuropathology - November 18, 2009 Category: Neurology Authors: Jaekyung Myung, Byung-Kyu Cho, Young-Soon Kim, Sung-Hye Park Source Type: journals

Regenerative biology: Brainy stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature 462, 255 (2009). doi:10.1038/462255d Proc. Natl Acad. Sci. USA106, 19150–19155 (2009) 10.1073/pnas.0909293106Patients undergoing irradiation for brain tumours often display signs of cognitive dysfunction, owing in part to the loss of healthy neural stem and precursor cells. To investigate possible treatments, Charles (Source: Nature)
Source: Nature - November 18, 2009 Category: Research Tags: Research Highlights Source Type: journals

Clinical and Mutational Spectrum of Neurofibromatosis Type 1-like Syndrome [Original Contribution]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A high SPRED1 mutation detection rate was found in NF1 mutation–negative families with an autosomal dominant phenotype of CALMs with or without freckling and no other NF1 features. Among individuals in this study, NFLS was not associated with the peripheral and central nervous system tumors seen in NF1. (Source: JAMA)
Source: JAMA - November 17, 2009 Category: Journals (General) Authors: Messiaen, L., Yao, S., Brems, H., Callens, T., Sathienkijkanchai, A., Denayer, E., Spencer, E., Arn, P., Babovic-Vuksanovic, D., Bay, C., Bobele, G., Cohen, B. H., Escobar, L., Eunpu, D., Grebe, T., Greenstein, R., Hachen, R., Irons, M., Kronn, D., Lemire Tags: Neurology, Neurogenetics, Neurocutaneous Diseases, Neuromuscular diseases, Diagnosis, Genetics, Genetic Disorders Original Contribution Source Type: journals

Policewoman is first in UK to have part of her skull replaced with ceramic plateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A police officer who was diagnosed with five brain tumours has become the first person in the UK to have part of their skull replaced with a ceramic implant. (Source: the Mail online | Health)
Source: the Mail online | Health - November 17, 2009 Category: Consumer Health News Source Type: news

Diagnosis of childhood cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Childhood cancer is uncommon but remains the leading cause of disease-related death in children. Symptoms are often vague or insidious; they may suggest a more common alternative diagnosis, and they are quite different from those associated with adult malignancy. The skilled office practitioner must consider cancer as a diagnosis when symptoms/signs persist or when multiple symptoms point toward a possible diagnosis of malignancy. Early diagnosis is critical, as survival rates have increased dramatically over the past decades. Prolonged delay in diagnosis is common, especially for brain tumors and certain lymphomas (Ho...
Source: Primary Care - November 17, 2009 Category: Primary Care Authors: Raab CP, Gartner JC Tags: Prim Care Source Type: journals

World's first delivery of intra-arterial Avastin directly into brain tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College) Neurosurgeons from NewYork-Presbyterian Hospital/Weill Cornell Medical Center performed the world's first intra-arterial cerebral infusion of Avastin (bevacizumab) directly into a patient's malignant brain tumor. This novel technique may expose the cancer to higher doses of the drug therapy, while possibly sparing the patient common side effects of receiving the drug intravenously or throughout their body. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 17, 2009 Category: Global & Universal Source Type: news

MeningiomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diagnosis, Treatment, and Outcome Meningiomas contains the most up-to-date information currently available on this increasingly common type of brain tumour, with contributions from internationally recognized experts in their respective fields working towards the uniform vision of one world-renowned editor.As the reported incidences of meningiomas found among otherwise healthy patients has increased over the last ... (Source: Springer Medicine titles)
Source: Springer Medicine titles - November 17, 2009 Category: Databases & Libraries Tags: Neurosurgery Source Type: organizations

Breaching a Barrier to Fight Brain CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An experimental treatment for glioblastoma suppresses a barrier to deliver a drug directly to brain tumors. (Source: NYT > Health)
Source: NYT > Health - November 16, 2009 Category: Consumer Health News Authors: By DENISE GRADY Tags: Avastin (Drug) Tumors Brain Medicine and Health Chemotherapy Source Type: news

Bevacizumab for recurrent ependymomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The radiographic response rate to bevacizumab-containing regimens is high. A prospective study is warranted. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Green, R. M., Cloughesy, T. F., Stupp, R., DeAngelis, L. M., Woyshner, E. A., Ney, D. E., Lassman, A. B. Tags: All Oncology, Primary brain tumor, Spinal cord tumor, Chemotherapy-tumor ARTICLES Source Type: journals

Image of brain tumour wins competitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 16, 2009 Category: Journals (General) Authors: Christie, B. Tags: Neurooncology, CNS cancer NEWS Source Type: journals

FAQ:Is an arachnoid cyst 4.25cm x 1.7 cm in the left middle cranial fossa with a mass effect on the temporal lobe concerning...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - November 15, 2009 Category: Cancer & Oncology Source Type: clinical trials

Goldhirsh Foundation 2010 Grant Cycle of the Brain Tumor Research Awards ProgramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Goldhirsh Foundation is pleased to announce the 2010 Grant Cycle of the Brain Tumor Research Awards Program. The next application deadline is Thursday, January 7, 2010, 12:00 Noon, U.S. and Canada Eastern Time (GMT-5) for awards beginning on July 1, 2010. The Goldhirsh Foundation was established by Bernard A. Goldhirsh in 2000, shortly after he was diagnosed with brain cancer. Since his death in 2003, the Board of Directors of the Foundation (which includes his two children) has been shaping a grantmaking program that reflects his values and entrepreneurial spirit. We are dedicated to making a difference in the lives ...
Source: ScanGrants feed - November 15, 2009 Category: Research Authors: Goldhirsh Foundation Source Type: funding

New Way To Biopsy Brain Tumors In Real TimeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new miniature, hand-held microscope may allow more precise removal of brain tumors and an easier recognition of tumor locations during surgery. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 14, 2009 Category: Science Source Type: news

Software For Solving Life-threatening Medical PuzzlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New software is under development that doctors hope will help them identify brain tumors in children that will grow aggressively. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 14, 2009 Category: Science Source Type: news

Impact of Pattern of Admission on ICH OutcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Patients with ICH brought directly to our ED had significantly better outcomes than IHT; we hypothesize this may be caused by delays in optimizing management prior to arrival at the facility with a dedicated Neuro-ICU. Nevertheless, other equally plausible hypotheses need to be prospectively tested. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12028-009-9302-0Authors Neeraj Sunderrajan Naval, Oregon Health & Science University Portland OR USAJ. Ricardo Carhuapoma, Johns Hopkins University Baltimore MD USA Journal Neurocritical CareOnline ISSN 1556-0961Print ISSN...
Source: Neurocritical Care - November 14, 2009 Category: Neurology Tags: Neurocritical Care Source Type: journals

Artificial Sweeteners are Continually Found to be Unsafe and ToxicEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) A recent study presented at the annual meeting of the American Society of Nephrology in San Diego found that adult women who drink at least two diet sodas a day experience a 30 percent drop in kidney function over the course of a decade. Findings indicate that artificial sweeteners such as aspartame and sucralose are the culprits in the rapid degeneration of glomerular filtration rates in the kidneys of those consuming excessive amounts of artificially-sweetened diet sodas.Dr. Julie Lin of Brigham and Women's Hospital in Boston and her colleague Dr. Gary Curhan conducted the research correlating artificial sw...
Source: NaturalNews.com - November 14, 2009 Category: Consumer Health Advice Source Type: news

S-Adenosylhomocysteine Promotes the Invasion of C6 Glioma Cells via Increased Secretion of Matrix Metalloproteinase-2 in Murine Microglial BV2 CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined the hypothesis that SAH may indirectly enhance the invasion of C6 glioma cells by induction of matrix metalloproteinase-2 (MMP-2) secreted from the murine microglia BV2 cells. We obtained conditioned medium (CM) by incubating BV2 cells with SAH (1–50nM) for 24 h. We found that the SAH-containing CM (SAH-BV2-CM) strongly enhanced the invasiveness of C6 glioma cells and that this effect increased with increasing concentrations of SAH in the SAH-BV2-CM. The effect of CM could be attributed to its MMP-2 activity, as a result of increased protein and messenger RNA expression of MMP-2 in BV2 cell...
Source: Toxicological Sciences - November 13, 2009 Category: Toxicology Authors: Lin, H.-C., Song, T.-Y., Hu, M.-L. Tags: CARCINOGENICITY Source Type: journals

Clinical impact of 11C-methionine PET on expected management of patients with brain neoplasmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion 11C-MET PET can provide useful information in initial diagnosis and differentiating tumor recurrence from radiation necrosis. The intended management was changed in half of the scans. Since a few cases did not receive the requisite treatment due to false-negative results of 11C-MET PET, management decision should be made carefully, especially in the case of a negative scan. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1302-yAuthors Tomohiko Yamane, Institution of Biomedical Research and Innovation Division of Molecular imaging 2-2 Minatojima-Minamimachi, Chu...
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 13, 2009 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

An Automatic Procedure for Normalization of Cerebral Blood Volume Maps in Dynamic Susceptibility Contrast-Based Glioma Imaging [BRAIN]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SUMMARY: To characterize gliomas from dynamic susceptibility contrast (DSC)–based cerebral blood volume (CBV) maps, a CBV value from a normal-appearing region of interest is typically identified manually and used to normalize the CBV maps. This method is user-dependent and time-consuming. We propose an alternative approach based on automatic identification of normal-appearing first-pass curves from brain tissue. Our results in 101 patients suggest similar or better diagnostic accuracy values than the manual approach. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - November 13, 2009 Category: Radiology Authors: Emblem, K.E., Bjornerud, A. Tags: BRAIN Source Type: journals

Focal Neuronal Gigantism: A Rare Complication of Therapeutic Radiation [BRAIN]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report this rare delayed complication in a patient following treatment of a right frontal anaplastic oligodendroglioma. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - November 13, 2009 Category: Radiology Authors: Gaughen, J.R., Bourne, T.D., Aregawi, D., Shah, L.M., Schiff, D. Tags: BRAIN Source Type: journals

The Dexamethasone-induced Inhibition of Proliferation, Migration, and Invasion in Glioma Cell Lines Is Antagonized by Macrophage Migration Inhibitory Factor (MIF) and Can Be Enhanced by Specific MIF Inhibitors [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we characterized several glioma cell lines for their MIF production. U373 MG cells were selected for their very low endogenous levels of MIF. We showed that dexamethasone inhibits the migration and invasion of U373 MG cells, through a glucocorticoid receptor (GR)- dependent inhibition of the ERK1/2 MAPK pathway. Oppositely, we found that exogenous MIF increases U373 MG migration and invasion through the stimulation of the ERK1/2 MAP kinase pathway and that this activation is CD74 independent. Finally, we used the Hs 683 glioma cells that are resistant to GCs and produce high levels of endogenous MIF, and sho...
Source: Journal of Biological Chemistry - November 13, 2009 Category: Chemistry Authors: Piette, C., Deprez, M., Roger, T., Noel, A., Foidart, J.-M., Munaut, C. Tags: Mechanisms Of Signal Transduction Source Type: journals

NBTS Funds Groundbreaking Study on Prevalence of Brain TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Study predicts incidence and underscores support needed for increased awareness. (Source: National Brain Tumor Society)
Source: National Brain Tumor Society - November 13, 2009 Category: Cancer & Oncology Source Type: organizations

Neurosurgery Resident`s Book Helps Ease Youths` Fears About Brain SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - November 13, 2009 Category: Cancer & Oncology Source Type: clinical trials

Cooking up a CURE for brain tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - November 13, 2009 Category: Cancer & Oncology Source Type: clinical trials