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Early Detection of Breast Cancer: New Biomarker Tests on the Horizon?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Diagnosis)
Source: Molecular Diagnosis - November 21, 2009 Category: Pathology Authors: Jotwani, Aparna C.Gralow, Julie R. Tags: Review Articles Source Type: journals

Human Epidermal Growth Factor Receptor Dimerization Analysis in Breast Cancer Diagnosis: Potential for Improving Testing Accuracy and Treatment SelectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Diagnosis)
Source: Molecular Diagnosis - November 21, 2009 Category: Pathology Authors: Spears, MelanieBartlett, John M.S. Tags: Review Articles Source Type: journals

Molecular Imaging: A Potential New Tool for Early Detection and Monitoring of Targeted Breast Cancer Therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19922302 [PubMed - as supplied by publisher] (Source: Acta Radiologica)
Source: Acta Radiologica - November 21, 2009 Category: Radiology Authors: Skaane P Tags: Acta Radiol Source Type: journals

Characterizing Breast Cancer Xenograft Epidermal Growth Factor Receptor Expression by Using Near-Infrared Optical Imaging.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Erbitux-Cy5.5 may be used as a specific NIR contrast agent for the noninvasive characterization of EGFR expression level in breast cancer xenografts. PMID: 19922304 [PubMed - as supplied by publisher] (Source: Acta Radiologica)
Source: Acta Radiologica - November 21, 2009 Category: Radiology Authors: Wang K, Wang K, Li W, Huang T, Li R, Wang D, Shen B, Chen X Tags: Acta Radiol Source Type: journals

Breast cancer imaging: A multidisciplinary, multimodality approach. Third edition. By M. Tartar, C. E. Comstock, & M. S. Kipper. Philadelphia, PA: Mosby Elsevier, 2008. 614 pages. ISBN: 978-0-323-04677-0. Hardcover.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breast cancer imaging: A multidisciplinary, multimodality approach. Third edition. By M. Tartar, C. E. Comstock, & M. S. Kipper. Philadelphia, PA: Mosby Elsevier, 2008. 614 pages. ISBN: 978-0-323-04677-0. Hardcover. Acta Radiol. 2009 Dec;50(10):1186 Authors: Skaane P PMID: 19922318 [PubMed - as supplied by publisher] (Source: Acta Radiologica)
Source: Acta Radiologica - November 21, 2009 Category: Radiology Authors: Skaane P Tags: Acta Radiol Source Type: journals

Will Women in Their 40s Be Denied Yearly Mammograms?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deciding not to do mammograms on young women because the current technology is imperfect shouldn't result in the decision to use no technology at all. (Source: Breast Cancer Chronicles)
Source: Breast Cancer Chronicles - November 21, 2009 Category: Consumer Health Advice Source Type: consumer

Getting to the facts in the debate on mammogramsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The U.S. Preventive Services Task Force's revised guidelines have been praised and criticized. The American Cancer Society is one group that disagrees. It's such an appealing idea -- catch breast cancer early, treat accordingly and your patients will live. (Source: L.A. Times - Health)
Source: L.A. Times - Health - November 21, 2009 Category: Consumer Health News Source Type: news

Scrutiny for cancer screeningsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It's been a confusing week for women, with new guidelines for breast cancer and cervical cancer exams. Though the guidelines triggered controversy, one expert said, there could be a silver lining. (Source: CNN.com - Health)
Source: CNN.com - Health - November 21, 2009 Category: Consumer Health News Source Type: news

Cancer Guidelines ScrutinizedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Having read the front-page story "Changing Strategy" [Nov. 17], I was absolutely shocked. I am a breast cancer survivor and it was a self-examination that led to my diagnosis. Yet, the U.S. Preventive Services Task Force has the audacity to recommend... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - November 21, 2009 Category: American Health Source Type: news

Latissimus DorsiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The latissimus dorsi is a broad, triangular flat muscle on your back. It is connected to bones in your spine, shoulder and arms. (Source: About.com Breast Cancer)
Source: About.com Breast Cancer - November 21, 2009 Category: Cancer & Oncology Authors: breastcancer.guide at about.com Tags: health Source Type: consumer

Screening for Prostate and Breast CancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Have the benefits of screening for prostate and breast cancer been overstated? Journal Watch (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 20, 2009 Category: Consumer Health News Tags: Internal Medicine Source Type: news

Mammography Guidelines Jolt Medical FieldEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The new guidelines on breast cancer screening have instantly ignited an emotionally charged firestorm among physicians across the country. (Source: WebMD Health)
Source: WebMD Health - November 20, 2009 Category: Consumer Health News Source Type: news

Preoperative Sonographic Classification of Axillary Lymph Nodes in Patients With Breast Cancer: Node-to-Node Correlation With Surgical Histology and Sentinel Node Biopsy ResultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION. Sonographic classification of axillary lymph nodes is effective for predicting the presence of metastases to avoid sentinel node biopsy or to reduce unsuccessful lymphatic mapping during sentinel node biopsy. (Source: American Journal of Roentgenology)
Source: American Journal of Roentgenology - November 20, 2009 Category: Radiology Authors: Cho, N., Moon, W. K., Han, W., Park, I. A., Cho, J., Noh, D.-Y. Tags: Women's Imaging Source Type: journals

Docetaxel, Trastuzumab Both Improve Survival in Early Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In women with node-positive or high-risk node-negative early breast cancer, disease-free survival was better when docetaxel was substituted for vinorelbine as an adjuvant therapy to fluorouracil, epirubicin and cyclophosphamide (FEC). Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 20, 2009 Category: Consumer Health News Tags: Hematology-Oncology Source Type: news

Serum Insulin Level Tied to Postmenopausal Breast Cancer RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Elevated serum levels of insulin may increase the risk of breast cancer in postmenopausal women, according to research reported in the December 15 issue of the International Journal of Cancer. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 20, 2009 Category: Consumer Health News Tags: Hematology-Oncology Source Type: news

Blocking Tissue Stiffening Enzyme Could Be Key To Preventing Aggressive CancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A team of scientists from the US and the UK have shown that blocking an enzyme called lysyl oxidase (LOX) that causes tissue to stiffen reduces the likelihood of abnormal but non-malignant breast tissue turning into tumors, suggesting that LOX and similar enzymes could be new targets for effective anti-cancer drug therapies. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: breast cancer Source Type: news

Blocking Tissue Stiffening Enzyme Could Be Key To Preventing Aggressive CancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A team of scientists from the US and the UK have shown that blocking an enzyme called lysyl oxidase (LOX) that causes tissue to stiffen reduces the likelihood of abnormal but non-malignant breast tissue turning into tumors, suggesting that LOX and similar enzymes could be new targets for effective anti-cancer drug therapies. (Source: Breast Cancer News From Medical News Today)
Source: Breast Cancer News From Medical News Today - November 20, 2009 Category: Cancer & Oncology Tags: breast cancer Source Type: news

Research Library: KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Nature Signaling Update)
Source: Nature Signaling Update - November 20, 2009 Category: Research Source Type: info

Protein Kinase C{delta} Supports Survival of MDA-MB-231 Breast Cancer Cells by Suppressing the ERK1/2 Pathway [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mechanisms that mediate apoptosis resistance are attractive therapeutic targets for cancer. Protein kinase C (PKC) is considered a pro-apoptotic factor in many cell types. In breast cancer, however, it has shown both pro-survival and pro-apoptotic effects. Here, we report for the first time that down-regulation of PKC per se leads to apoptosis of MDA-MB-231 cells. Inhibition of MEK1/2 by either PD98059 or U0126 suppressed the induction of apoptosis of PKC-depleted MDA-MB-231 cells but did not support survival of MCF-7 or MDA-MB-468 cells. Basal ERK1/2 phosphorylation was substantially higher in MDA-MB-231 cells than in the...
Source: Journal of Biological Chemistry - November 20, 2009 Category: Chemistry Authors: Lonne, G. K., Masoumi, K. C., Lennartsson, J., Larsson, C. Tags: Mechanisms Of Signal Transduction Source Type: journals

Breast Cancer-derived Factors Stimulate Osteoclastogenesis through the Ca2+/Protein Kinase C and Transforming Growth Factor-{beta}/MAPK Signaling Pathways [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breast cancer commonly metastasizes to bone where its growth depends on the action of bone-resorbing osteoclasts. We have previously shown that breast cancer cells secrete factors able to directly stimulate osteoclastogenesis from receptor activator of nuclear factor B ligand (RANKL)-primed precursors and that transforming growth factor-β (TGFβ) plays a permissive role in this process. Now, we evaluate the signaling events triggered in osteoclast precursors by soluble factors produced by MDA-MB-231 human breast carcinoma cells. In mouse bone marrow cultures and RAW 264.7 murine monocytic cells, MDA-MB-231-derived...
Source: Journal of Biological Chemistry - November 20, 2009 Category: Chemistry Authors: Tiedemann, K., Hussein, O., Sadvakassova, G., Guo, Y., Siegel, P. M., Komarova, S. V. Tags: Mechanisms Of Signal Transduction Source Type: journals

CYP2D6 predicted treatment outcome in tamoxifen-treated metastatic breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: HemOncToday.com)
Source: HemOncToday.com - November 20, 2009 Category: Cancer & Oncology Source Type: info

Lapatinib monotherapy feasible for HER2-positive metastatic breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lapatinib monotherapy is an effective treatment for patients with human epidermal growth factor receptor 2-positive advanced or metastatic breast cancer that has relapsed after trastuzumab treatment, Japanese research suggests. (Source: MedWire News - Breast Cancer)
Source: MedWire News - Breast Cancer - November 20, 2009 Category: Cancer & Oncology Source Type: news

Lapatinib monotherapy feasible for HER2-positive metastatic breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lapatinib monotherapy is an effective treatment for patients with human epidermal growth factor receptor 2-positive advanced or metastatic breast cancer that has relapsed after trastuzumab treatment, Japanese research suggests. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - November 20, 2009 Category: Cancer & Oncology Source Type: news

Insurers Say They Won't Alter Mammogram Coverage Despite New GuidelinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Insurance companies say mammogram coverage is unlikely to change despite the debate over the effectiveness of breast cancer screenings for women in their forties. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: breast cancer Source Type: news

Columnists, Rep. Stupak Comment On Abortion Restrictions In House Health Reform BillEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several newspapers recently published opinion pieces regarding an amendment sponsored by Reps. Bart Stupak's (D-Mich.) and Joe Pitts (R-Pa.) to the House health care reform bill (HR 3962) that would prohibit abortion coverage in private and public health plans that receive federal subsidies. Summaries appear below. (Source: Breast Cancer News From Medical News Today)
Source: Breast Cancer News From Medical News Today - November 20, 2009 Category: Cancer & Oncology Tags: Abortion Source Type: news

Insurers Say They Won't Alter Mammogram Coverage Despite New GuidelinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Insurance companies say mammogram coverage is unlikely to change despite the debate over the effectiveness of breast cancer screenings for women in their forties. (Source: Breast Cancer News From Medical News Today)
Source: Breast Cancer News From Medical News Today - November 20, 2009 Category: Cancer & Oncology Tags: breast cancer Source Type: news

Ultrasound targets lymph node recurrence in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ultrasound is an effective way to monitor lymph node recurrence after breast cancer surgery, South Korean researchers reported. Regional lymph node recurrence affects just 2% to 16% of patients with any stage of breast cancer, but is difficult to manage and associated with poor prognosis. (Source: Cancer Network)
Source: Cancer Network - November 20, 2009 Category: Cancer & Oncology Source Type: info

HHS Sec. Sebelius Says New Mammogram Guidelines Will Not Change Federal PoliciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HHS Secretary Kathleen Sebelius on Wednesday said that federal health insurance programs will not alter their mammogram coverage policies following new recommendations from the U.S. Preventive Services Task Force, the New York Times reports. The guidelines, released earlier this week, promote mammograms every two years for most women starting at age 50. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: breast cancer Source Type: news

HHS Sec. Sebelius Says New Mammogram Guidelines Will Not Change Federal PoliciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HHS Secretary Kathleen Sebelius on Wednesday said that federal health insurance programs will not alter their mammogram coverage policies following new recommendations from the U.S. Preventive Services Task Force, the New York Times reports. The guidelines, (Source: Breast Cancer News From Medical News Today)
Source: Breast Cancer News From Medical News Today - November 20, 2009 Category: Cancer & Oncology Tags: breast cancer Source Type: news

Esteemed Endorsements Recognize Promising Future Of Breast-Specific Gamma Imaging (BSGI)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breast-Specific Gamma Imaging/Molecular Breast Imaging (BSGI/MBI) has been recognized and endorsed by two highly esteemed organizations for the fight against breast cancer: The Society of Breast Imaging (SBI) and the American College of Surgeons. Both societies published articles supporting the further application of this breakthrough imaging technology for the early detection of breast cancer. (Source: Breast Cancer News From Medical News Today)
Source: Breast Cancer News From Medical News Today - November 20, 2009 Category: Cancer & Oncology Tags: breast cancer Source Type: news

Esteemed Endorsements Recognize Promising Future Of Breast-Specific Gamma Imaging (BSGI)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breast-Specific Gamma Imaging/Molecular Breast Imaging (BSGI/MBI) has been recognized and endorsed by two highly esteemed organizations for the fight against breast cancer: The Society of Breast Imaging (SBI) and the American College of Surgeons. Both societies published articles supporting the further application of this breakthrough imaging technology for the early detection of breast cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: breast cancer Source Type: news

Group recommends less-frequent Pap testsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cervical cancer screening advice follows another panel's controversial mammogram report, but experts say it's a much different situation. Still, Paps are the only reason some women see a doctor. Only days after a federal panel scaled back on breast cancer screening recommendations for many women, another organization -- the American College of Obstetricians and Gynecologists -- has done the same for a screening credited with drastically reducing the rates of cervical cancer in the U.S. (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - November 20, 2009 Category: Science Source Type: news

Group recommends less-frequent Pap testsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cervical cancer screening advice follows another panel's controversial mammogram report, but experts say it's a much different situation. Still, Paps are the only reason some women see a doctor. Only days after a federal panel scaled back on breast cancer screening recommendations for many women, another organization -- the American College of Obstetricians and Gynecologists -- has done the same for a screening credited with drastically reducing the rates of cervical cancer in the U.S. (Source: L.A. Times - Health)
Source: L.A. Times - Health - November 20, 2009 Category: Consumer Health News Source Type: news

Adding tools against breast tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
At the end of a 10-year, coast-to-coast study of women with an unusual form of breast cancer, medical researchers are making the case for a particular combination of treatments to stop the tumors in their tracks. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 20, 2009 Category: Science Source Type: news

Twenty-one questions about mammograms, cancer screenings and early detectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) There's a lot of talk about mammograms and cancer screenings this week. A U.S. government task force altered its recommendations, saying that women under 50 should receive no mammograms at all because the risk of harm far outweighs any promise of saving lives. This, in turn, led to a very vocal backlash from cancer industry promoters and even a few deeply misinformed celebrities like Sheryl Crow who swear by mammograms. (Sheryl Crow has a poor understanding of the effects of ionizing radiation.)Rather than providing new answers, this week's debates on mammograms have actually raised all sorts of new questions...
Source: NaturalNews.com - November 20, 2009 Category: Consumer Health Advice Source Type: news

Mammogram Debate Took Group by SurpriseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Preventive Services Task Force, which urged women to get less-frequent screening for breast cancer, was created to be apolitical. (Source: NYT > Health)
Source: NYT > Health - November 20, 2009 Category: Consumer Health News Authors: By GINA KOLATA Tags: Mammography Medicine and Health Reform and Reorganization Tests and Testing Cancer American Cancer Society Source Type: news

Effect of Collimator and Couch Angle Change on Breast IMRT Dose Distributions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this work is to investigate the effects of the collimator and the couch angle change on the dose distribution for breast cancer treatment using intensity modulated tangential photon beams, and thus to determine the clinical acceptable range of the angle change for routine treatment. Ten breast cases treated with intensity modulated tangential photon beams were analyzed in this study. Patient-specific CT data and the RTP files obtained from our home-grown Monte Carlo based breast IMRT treatment planning system were used for IMRT dose re-calculation with collimator or couch angle changes. The isodose distrib...
Source: Journal of Applied Clinical Medical Physics - November 20, 2009 Category: Physics Authors: Yang J, Ma C, Wang L, Chen L, Li J Tags: J Appl Clin Med Phys Source Type: journals

Group Clarifies Mammography AdviceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The task force that loosened breast-cancer screening guidelines this week clarified its position, in response to the intense backlash its new recommendations have prompted. (Source: WSJ.com: Health)
Source: WSJ.com: Health - November 20, 2009 Category: Pharmaceuticals Tags: FREE Source Type: news

Group Clarifies Mammograph AdviceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The task force that loosened breast-cancer screening guidelines this week clarified its position, in response to the intense backlash its new recommendations have prompted. (Source: WSJ.com: Health)
Source: WSJ.com: Health - November 20, 2009 Category: Pharmaceuticals Tags: FREE Source Type: news

Management of Symptomatic Bone Metastases from Breast Cancer with Concomitant Use of External Radiotherapy and Ibandronate: Results of a Prospective, Pilot StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The Breast Journal)
Source: The Breast Journal - November 20, 2009 Category: Cancer & Oncology Authors: Vassilios Vassiliou, Christine Kalogeropoulou, Leotsinidis Mihael, Athanassios Tsamandas, Theodoros Petsas, Efstathia Giannopoulou, Dimitrios Kardamakis Source Type: journals

Breast Cancer Survivors Disagree With New Mammogram AdviceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
After losing her mother to cancer, Shelia Weeks, 61, was advised by her doctor to begin receiving mammograms when she was 36. Her mother's cancer was found in her liver, but started in her breast. There was no widespread detection method such as mammograms at that time. She passed away in 1982. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - November 20, 2009 Category: Cancer & Oncology Source Type: news

Characterisation of microRNA expression in post-natal mouse mammary gland developmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: MicroRNAs were expressed in likely co-regulated clusters during mammary gland development. Breast cancer-associated miRNAs were significantly enriched in these clusters. The mechanism and functional consequences of this miRNA co-regulation provide new avenues for research into mammary gland biology and generate candidates for functional validation. (Source: BioMed Central)
Source: BioMed Central - November 20, 2009 Category: Journals (General) Authors: Stefanie Avril-SassenLeonard GoldsteinJohn StinglCherie BlenkironJohn Le QuesneInmaculada SpiteriKonstantina KaragavriilidouChristine WatsonSimon TavareEric MiskaCarlos Caldas Source Type: journals

Ligand-specific sequential regulation of transcription factors for differentiation of MCF-7 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our analysis indicated that a time-dependent transcriptional regulatory network including c-FOS, FRA-1, and FHL2 is vital in controlling the ERK signaling pathway through a negative feedback loop for MCF-7 cell differentiation. (Source: BMC Genomics - Latest articles)
Source: BMC Genomics - Latest articles - November 20, 2009 Category: Genetics & Stem Cells Authors: Yuko SaekiTakaho EndoKaori IdeTakeshi NagashimaNoriko YumotoTetsuro ToyodaHarukazu SuzukiYoshihide HayashizakiYoshiyuki SakakiMariko Okada-Hatakeyama Source Type: journals

Anaphylaxis to patent blue V: a case series and proposed diagnostic protocolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patent blue V is widely used in the identification of sentinel lymph nodes in patients with breast cancer and other malignancies. Individual case reports of allergy to patent blue V have been described in the medical literature since the 1960s. However, there is little data on clinical features and little experience of which allergy tests are appropriate or useful. We gathered all cases of patent blue V allergy that had been seen and diagnosed in the Department of Allergy, Addenbrooke's Hospital over a 3-year period. We collected clinical details of each case including skin test results. For comparison we recruited 12 heal...
Source: Allergy - November 20, 2009 Category: Allergy & Immunology Authors: R. A. Haque, A. Wagner, J. A. Whisken, S. M. Nasser, P. W. Ewan Source Type: journals

Disruption of the blood brain barrier by brain metastases of triple-negative and basal-type breast cancer but not HER2/neu-positive breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Generally, the blood-brain barrier (BBB) of brain metastasis was thought to be disrupted.We retrospectively performed immunohistochemical staining for glucose transporter 1 (GLUT1) and breast cancer resistance protein (BCRP) to evaluate the status of the BBB in resected brain metastases. Associations between expression of GLUT1 and/or BCRP and the immunohistochemical profiles of breast cancers, such as the statuses of hormone receptors, human epidermal growth factor receptor 2 (HER2/neu), and a basal-type marker (cytokeratin 5/6, HER1), were also analyzed.The study included 29 breast cancer patients with brain metastasis w...
Source: Cancer - November 20, 2009 Category: Cancer & Oncology Authors: Kan Yonemori, Koji Tsuta, Makiko Ono, Chikako Shimizu, Akihiro Hirakawa, Tadashi Hasegawa, Yutaka Hatanaka, Yoshitaka Narita, Soichiro Shibui, Yasuhiro Fujiwara Source Type: journals

[Correlation analysis of vascular endothelial growth factor-C expression and clinicopathology in breast cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The high expressions of VEGF-C and C-erbB-2 are closely related to lymph node metastasis in breast cancer patients, and may cooperate in promoting lymph node metastasis of breast carcinoma. Combined detection of VEGF-C, C-erbB-2, p53, ER and PR may help clinical treatment and prognostic evaluation of breast cancer patients. PMID: 19923084 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Fu JM, Shi J, Zhou J Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

[Abnormal expression of beta-catenin and E-cadherin in Her2-positive breast cancer and its implications.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A direct correlation between positive Her2 expression and abnormal beta-catenin expression exists in human breast carcinoma, and positive Her2 expression may have functional interactions with abnormal activation of Wnt/beta-catenin signaling pathway. PMID: 19923077 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Niu LG, He JJ, Wang K, Zhang W, Zhou C Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

[Evaluation on parallel HER-2 testing using in situ hybridization and immunohistochemistry in breast cancer tissues.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: IHC can be used as a screening method for detecting HER-2 gene amplification, and FISH should be performed in cases of HER-2 gene overexpression (3+/2+) as detected by IHC. PMID: 19923073 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Pan XY, Gao HY, Zhang JL, Fu WT, Liu S Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

[Construction of an expression vector carrying short hairpin RNA targeting hTERT gene and its effects on breast cancer cell telomerase activity and proliferation in vivo.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Transfection with the recombinant plasmid containing the shRNA targeting hTERT gene can down-regulate telomerase activity and inhibit proliferation of breast cancer cells in vitro, suggesting the potential of gene therapy targeting telomerase in the treatment of breast cancer. PMID: 19923062 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Liu XX, Yao C, Zhang H, Wang SM, Wang SM Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals