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This page shows you the latest news and research items in this category.

Imaging joints for calcium pyrophosphate crystal deposition: a knock to the knees
With advanced age, articular calcium pyrophosphate crystal deposition (CPPD) is common. Defining who has CPPD is of growing importance, given increases in longevity in many countries and the frequent association of chondrocalcinosis with osteoarthritis. Chondrocalcinosis detected by plain radiography serves as a major screening tool, but how many and which sites to screen have not been adequately defined in the past. The work of Abhishek and colleagues in the previous issue of Arthritis Research and Therapy sheds new light on the incomplete information from knee radiographs, and helps position us to learn more about the ep...
Source: Arthritis Research and Therapy - December 27, 2012 Category: Rheumatology Authors: Robert Terkeltaub Source Type: research

Imaging joints for calcium pyrophosphate crystal deposition: a knock to the knees
With advanced age, articular calcium pyrophosphate crystal deposition (CPPD) is common. Defining who has CPPD is of growing importance, given increases in longevity in many countries and the frequent association of chondrocalcinosis with osteoarthritis. Chondrocalcinosis detected by plain radiography serves as a major screening tool, but how many and which sites to screen have not been adequately defined in the past. The work of Abhishek and colleagues in the previous issue of Arthritis Research and Therapy sheds new light on the incomplete information from knee radiographs, and helps position us to learn more about the ep...
Source: BioMed Central - December 27, 2012 Category: Journals (General) Authors: Robert Terkeltaub Source Type: research

Leukopenia associated with long-term colchicine administration.
Conclusion A patient with CLL developed leukopenia in association with colchicine administration for pseudogout. PMID: 23230037 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - December 15, 2012 Category: Drugs & Pharmacology Authors: Beggs AE, Reeves DJ, Noel NS Tags: Am J Health Syst Pharm Source Type: research

Cauda equina syndrome caused by pseudogout involving the lumbar intervertebral disc.
Abstract Calcium pyrophosphate dihydrate (CPPD) deposition disease, also known as pseudogout, is a disease that causes inflammatory arthropathy in peripheral joints, however, symptomatic involvement of the intervertebral disc is uncommon. Herein, we describe a 59-yr-old patient who presented with cauda equina syndrome. Magnetic resonance imaging of the patient showed an epidural mass-like lesion at the disc space of L4-L5, which was compressing the thecal sac. Biopsy of the intervertebral disc and epidural mass-like lesion was determined to be CPPD deposits. We reviewed previously reported cases of pseudogout invol...
Source: J Korean Med Sci - December 1, 2012 Category: Journals (General) Authors: Lee J, Cho KT, Kim EJ Tags: J Korean Med Sci Source Type: research

Calcium Pyrophosphate Dihydrate Deposition Disease Involving the Temporomandibular Joint
Background: Calcium pyrophosphate dehydrate (CPPD) crystal deposition disease is a type of crystal-forming arthritis with deposition of CPPD in the joint tissues. Deposition of CPPD often occurs in the articular tissues of the appendicular skeleton and less commonly the temporomandibular joint (TMJ). (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - October 19, 2012 Category: ENT & OMF Tags: 16th International Congress on Oral Pathology and Medicine and 20th Brazilian Congress of Oral Medicine and Pathology 2012 (São Pedro-Brazil, 30th July – 03rd August 2012) Source Type: research

Asymptomatic calcium pyrophosphate dihydrate deposition disease causing carpal tunnel syndrome: case report.
We describe an 87-year-old male who presented to us with asymptomatic form of deposition with multiple flexor tendon calcifications causing chronic median nerve compression. Simple carpal tunnel decompression relieved his median nerve symptoms. PMID: 22351540 [PubMed - indexed for MEDLINE] (Source: Hand Surgery)
Source: Hand Surgery - August 12, 2012 Category: Surgery Authors: Dodakundi C, Hattori Y, Doi K, Sakamoto S, Fujihara Y Tags: Hand Surg Source Type: research

The diagnosis of calcium pyrophosphate dihydrate crystal deposition disease: the good, the bad and… ultrasonography!
Abstract The diagnosis of calcium pyrophosphate dihydrate crystal deposition disease (CPPD) until recent years has been mainly based on the finding of typical crystals of calcium pyrophosphate dihydrate (CPP) in the synovial fluid of affected patients and on the presence of typical calcifications on plain X-rays.... PMID: 22842294 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - August 12, 2012 Category: Rheumatology Authors: Filippou G, Frediani B Tags: Reumatismo Source Type: research

Imaging studies of crystalline arthritides.
Abstract Gout, calcium pyrophosphate dihydrate (CPPD) deposition disease, and calcium hydroxyapatite deposition disease (HADD) are the three most common crystal-induced arthropathies. Multimodality imaging may help in their diagnosis, and is useful for a precise and comprehensive assessment and grading of the related osteoarticular damage. Plain film radiography, due to its low cost and wide availability, is the first imaging technique to be used in crystal deposition diseases, providing well-known and specific findings for CPPD deposition disease and HADD, while it may undergrade the early osteoarticular lesions i...
Source: Reumatismo - August 12, 2012 Category: Rheumatology Authors: Paparo F, Fabbro E, Ferrero G, Piccazzo R, Revelli M, Camellino D, Garlaschi G, Cimmino MA Tags: Reumatismo Source Type: research

Calcium pyrophosphate deposition disease: clinical manifestations.
Abstract Calcium pyrophosphate deposition (CPPD) disease is an arthropathy caused by calcium pyrophosphate dihydrate (CPP) crystal deposits in articular tissues, most commonly fibrocartilage and hyaline cartilage. According to EULAR, four different clinical presentations can be observed: 1) asymptomatic CPPD; 2) osteoarthritis (OA) with CPPD; 3) acute CPP crystal arthritis; 4) chronic CPP inflammatory crystal arthritis. Acute CPP crystal arthritis is characterized by sudden onset of pain, swelling and tenderness with overlying erythema, usually in a large joint, most often the knee, wrist, shoulder, and hip. Occasi...
Source: Reumatismo - August 12, 2012 Category: Rheumatology Authors: Ferrone C, Andracco R, Cimmino MA Tags: Reumatismo Source Type: research

Metabolism of crystals within the joint.
Abstract Monosodium urate (MSU), calcium pyrophosphate dihydrate (CPPD) and basic calcium phosphate (BCP) crystals deposit in joints and surrounding tissues causing acute inflammation and chronic cartilage damage. A number of endogenous substances and physicochemical conditions affect their precipitation, growth and even dissolution, regulating their metabolism and inflammatory activity. We review how MSU and calcium crystals form within the joints and the various factor which regulate their formation. PMID: 22303528 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - August 12, 2012 Category: Rheumatology Authors: Oliviero F, Scanu A, Punzi L Tags: Reumatismo Source Type: research

Treatment of hyperuricemia, gout and other crystalline arthritidies.
Abstract Gout is a very common joint disease which is due to chronic hyperuricemia and its related articular involvements. Yet it can be cured when appropriately managed. Comprehensive management of gout involves correct identification and addressing all causes of hyperuricemia, treating and preventing attacks of gouty inflammation (using colchicine NSAIDs, and/or steroids), and lowering serum urate (SUA) to an appropriate target level indefinitely. The ideal SUA target is, at a minimum, less than 6 mg/dL (60 mg/L or 360 μmol/L), or even less than 5 mg/dL in patients with tophi. The SUA target should remain at les...
Source: Reumatismo - August 12, 2012 Category: Rheumatology Authors: Lioté F Tags: Reumatismo Source Type: research

Progressive thoracic myelopathy caused by spinal calcium pyrophosphate crystal deposition because of proximal junctional vertebral compression fracture after lumbopelvic fusion
Conclusions The combination of mechanical stress plus PJF and CPPD crystal deposition followed by a foreign body reaction to the deposited crystals caused myelopathy. Patients with radiographic evidence of PJF, especially UIV collapse, after lumbopelvic fusion should be followed carefully for the emergence of myelopathy. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00586-012-2410-0Authors Seiichi Odate, Department of Orthopaedic Surgery, Spine Center, Gakkentoshi Hospital, 7-4-1 Seikacho, Seikadai, Sorakugun, Kyoto, JapanJitsuhiko Shikata, Department of Orthopaedic Surg...
Source: European Spine Journal - June 21, 2012 Category: Orthopaedics Tags: European Spine Journal Source Type: research

Relationship between the degeneration of the cruciate ligaments and calcium pyrophosphate dihydrate crystal deposition: anatomic, radiologic study with histologic correlation
Abstract: To investigate the association of calcium pyrophosphate dihydrate (CPPD) crystal deposition and cruciate ligament (CL) degeneration, 10 cadaveric knees were studied with 1.5-T magnetic resonance imaging and sectioned in three planes. The slices were evaluated with high-resolution Faxitron radiography. The images and specimens were evaluated by two radiologists. Histologic sections were obtained from eight that contained calcifications and from two without calcifications. Radiographs and histologic analysis demonstrated CPPD crystal deposition in 80% of specimens and 75% of CLs in these eight specimens. Degenerati...
Source: Clinical Imaging - May 28, 2012 Category: Radiology Authors: Berna Dirim, Donald Resnick, Marcelo Abreu, Mani Wangwinyuvirat, Debra J. Trudell, Parviz Haghighi Tags: Original Articles Source Type: research

Mineralization of articular cartilage in the sprague-dawley rat: characterization and mechanical analysis
The formation of mineralized deposits in human articular cartilage is a common occurrence; however, the relationship between mineral deposition and material properties of the articular cartilage is not well understood nor the relationship between mineral deposition and the development of degenerative joint disease. Several different crystalline structures have been identified in articular cartilage and synovial fluid including monosodium urate, calcium pyrophosphate dihydrate (CPPD), and basic calcium phosphates (BCPs). These distinct mineral phases are associated with specific pathologies and mechanisms of crystal formati...
Source: Osteoarthritis and Cartilage - May 18, 2012 Category: Rheumatology Authors: M.L. Roemhildt, B.D. Beynnon, M. Gardner-Morse Tags: Original Articles Source Type: research

Dried cytospin preparations of synovial fluid are a stable material for long-time storage and delayed crystal analysis
In conclusion, dried cytospin preparations were confirmed as a suitable material for long-time storage and delayed crystal identification. Content Type Journal ArticleCategory Brief ReportPages 1-2DOI 10.1007/s10067-012-1967-7Authors Christoph Robier, Central Laboratory, Department of Internal Medicine, Hospital Barmherzige Brueder, Bergstrasse 27, 8020 Graz-Eggenberg, AustriaManfred Neubauer, Central Laboratory, Department of Internal Medicine, Hospital Barmherzige Brueder, Bergstrasse 27, 8020 Graz-Eggenberg, AustriaMariana Stettin, Central Laboratory, Department of Internal Medicine, Hospital Barmherzige Brueder...
Source: Clinical Rheumatology - March 14, 2012 Category: Rheumatology Tags: Clinical Rheumatology Source Type: research

Tophaceous pseudogout of the thoracic spine
We present the case of a 72-year-old man with 6 months of left chest pain; magnetic resonance imaging revealed a T9/T10 herniated disc. Intraoperatively, the material was sent for pathological analysis revealing pseudogout. Axial calcium pyrophosphate crystal deposition is rare but reported in the literature and found at the craniocervical junction and skull. Spinal calcium pyrophosphate crystal deposition is rare in the thoracic spine. It is often asymptompatic and can involve the disc or ligaments. This case demonstrates a unique presentation of CPDD. Content Type Journal ArticleCategory Case ReportPages 1-4DOI...
Source: Acta Neurochirurgica - February 26, 2012 Category: Neurology Tags: Acta Neurochirurgica Source Type: research

Magnetic Resonance Imaging of Shoulder Arthropathies
This article reviews 4 of the major arthropathies: septic arthritis, rheumatoid arthritis, calcium pyrophosphate dihydrate (CPPD) deposition disease, and hydroxyapatite disease (HAD), with special attention to their magnetic resonance imaging features. Comfort with identifying these entities allows appropriate and prompt treatment, which is critical for joint preservation in the case of infection, for maximal therapeutic efficacy of disease-modifying drugs in the case of rheumatoid arthritis, and for expediting symptomatic relief in the cases of CPPD deposition disease and HAD. (Source: Magnetic Resonance Imaging Clinics of North America)
Source: Magnetic Resonance Imaging Clinics of North America - February 20, 2012 Category: Radiology Authors: A. Ross Sussmann, Jodi Cohen, George C. Nomikos, Mark E. Schweitzer Source Type: research

Metabolism of crystals within the joint.
Abstract Monosodium urate (MSU), calcium pyrophosphate dihydrate (CPPD) and basic calcium phosphate (BCP) crystals deposit in joints and surrounding tissues causing acute inflammation and chronic cartilage damage. A number of endogenous substances and physicochemical conditions affect their precipitation, growth and even dissolution, regulating their metabolism and inflammatory activity. We review how MSU and calcium crystals form within the joints and the various factor which regulate their formation. PMID: 22303528 [PubMed - in process] (Source: Reumatismo)
Source: Reumatismo - February 14, 2012 Category: Rheumatology Authors: Oliviero F, Scanu A, Punzi L Tags: Reumatismo Source Type: research

Imaging studies of crystalline arthritides.
Abstract Gout, calcium pyrophosphate dihydrate (CPPD) deposition disease, and calcium hydroxyapatite deposition disease (HADD) are the three most common crystal-induced arthropathies. Multimodality imaging may help in their diagnosis, and is useful for a precise and comprehensive assessment and grading of the related osteoarticular damage. Plain film radiography, due to its low cost and wide availability, is the first imaging technique to be used in crystal deposition diseases, providing well-known and specific findings for CPPD deposition disease and HADD, while it may undergrade the early osteoarticular lesions i...
Source: Reumatismo - February 14, 2012 Category: Rheumatology Authors: Paparo F, Fabbro E, Ferrero G, Piccazzo R, Revelli M, Camellino D, Garlaschi G, Cimmino MA Tags: Reumatismo Source Type: research

Treatment of hyperuricemia, gout and other crystalline arthritidies.
Abstract Gout is a very common joint disease which is due to chronic hyperuricemia and its related articular involvements. Yet it can be cured when appropriately managed. Comprehensive management of gout involves correct identification and addressing all causes of hyperuricemia, treating and preventing attacks of gouty inflammation (using colchicine NSAIDs, and/or steroids), and lowering serum urate (SUA) to an appropriate target level indefinitely. The ideal SUA target is, at a minimum, less than 6 mg/dL (60 mg/L or 360 μmol/L), or even less than 5 mg/dL in patients with tophi. The SUA target should remain at les...
Source: Reumatismo - February 14, 2012 Category: Rheumatology Authors: Lioté F Tags: Reumatismo Source Type: research

Calcium pyrophosphate deposition disease: clinical manifestations.
Abstract Calcium pyrophosphate deposition (CPPD) disease is an arthropathy caused by calcium pyrophosphate dihydrate (CPP) crystal deposits in articular tissues, most commonly fibrocartilage and hyaline cartilage. According to EULAR, four different clinical presentations can be observed: 1) asymptomatic CPPD; 2) osteoarthritis (OA) with CPPD; 3) acute CPP crystal arthritis; 4) chronic CPP inflammatory crystal arthritis. Acute CPP crystal arthritis is characterized by sudden onset of pain, swelling and tenderness with overlying erythema, usually in a large joint, most often the knee, wrist, shoulder, and hip. Occasi...
Source: Reumatismo - February 14, 2012 Category: Rheumatology Authors: Ferrone C, Andracco R, Cimmino MA Tags: Reumatismo Source Type: research

Ultrasonographic findings of Achilles tendon and plantar fascia in patients with calcium pyrophosphate deposition disease
Abstract The aims of the study were to detect the frequency of involvement of the Achilles tendon and plantar fascia in patients with calcium pyrophosphate deposition disease (CPPD) by high-frequency gray-scale ultrasonography (US) and power Doppler sonography (PDS) and to correlate these findings with demographic and clinical data. Two groups of patients were enrolled: group I (38 patients with CPPD) and group II (22 patients with knee OA). US/PDS examination of the heels was performed to both groups. In the CPPD group, US/PDS examination of the Achilles tendon revealed: calcification in 57.9%, enthesophyto...
Source: Clinical Rheumatology - December 28, 2011 Category: Rheumatology Tags: Clinical Rheumatology Source Type: research

Genetics and Mechanisms of Crystal Deposition in Calcium Pyrophosphate Deposition Disease
Abstract Calcium pyrophosphate deposition (CPPD) disease (common in older adults) can be asymptomatic, associated with osteoarthritis, or can present as acute/chronic inflammatory arthritis. Due to the phenotypic complexity of CPPD, the European League Against Rheumatism (EULAR) recently made recommendations on terminology, diagnosis, and management based on available research evidence and expert consensus. There are no disease-modifying treatments for CPPD disease, and therapy remains nonspecific with the use of anti-inflammatory and analgesic drugs. For years, it has been known that inorganic phosphate and...
Source: Current Rheumatology Reports - December 23, 2011 Category: Rheumatology Tags: Current Rheumatology Reports Source Type: research

Ultrasonographic diagnosis of articular chondrocalcinosis
Abstract To investigate the role of high-frequency ultrasonography in the diagnosis of calcium pyrophosphate dihydrate (CPPD) calcifications, in the most commonly affected joints in CPPD disease. Sixty patients with knee effusion were included in the study. All patients underwent musculoskeletal ultrasonography (on the shoulder, elbow, wrist, and knee joints), radiological examination of the sites examined by US, and synovial fluid analysis (using polarized light microscopy). Out of 60 patients with knee effusion, ultrasonographic calcifications (knees, shoulders, and wrists) were present in 38 patients (63....
Source: Rheumatology International - December 22, 2011 Category: Rheumatology Tags: Rheumatology International Source Type: research

Does Primary or Secondary Chondrocalcinosis Influence Long-term Survivorship of Unicompartmental Arthroplasty?
CONCLUSION: Our findings show chondrocalcinosis does not influence progression and therefore is not a contraindication to UKA. LEVEL OF EVIDENCE: Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence. PMID: 22161084 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - December 13, 2011 Category: Orthopaedics Authors: Hernigou P, Pascale W, Pascale V, Homma Y, Poignard A Tags: Clin Orthop Relat Res Source Type: research

Bartter’s and Gitelman’s diseases
Bartter’s and Gitelman’s syndromes are two different genetic renal diseases, but are both characterised by hypokalaemia and metabolic alkalosis. Bartter’s syndrome is characterised by multiple gene mutations (Na–K–2Cl cotransporter; K+ channels renal outer medullary potassium channel (ROMK); Cl channels, chloride channel Kb (ClCNKb); regulatory protein Barttin; and Ca2+ -sensing receptor, CaSR) at the thick ascending limb of Henle’s loop, while Gitelman’s syndrome is caused by a mutation in the gene encoding the renal thiazide sensitive Na+–Cl− cotransporter, located in the apical membrane of the distal c...
Source: Best Practice and Research. Clinical Rheumatology - October 1, 2011 Category: Rheumatology Authors: Marta Favero, Lorenzo A. Calò, Franco Schiavon, Leonardo Punzi Source Type: research

[The rheumatic hand - diagnostics in practice].
Abstract Many rheumatic diseases show changes and are visible in the hands. The pattern of distribution in the relevant joints, soft-tissue changes, skin manifestations, neurological and vascular symptoms and clinical findings provide fundamental information. Imaging and lab results provide diagnostic support. In this review, common diseases are presented in terms of their clinical expressions in the hands: osteoarthritis, rheumatoid arthritis, gout, calcium pyrophosphate dihydrate deposition disease, psoriatic arthritis, reactive arthritis, systemic sclerosis, dermatomyositis/polymyositis and systemic lupus erythe...
Source: Praxis - September 7, 2011 Category: Journals (General) Authors: Micheroli R, Kyburz D, Ciurea A, Tamborrini G Tags: Praxis (Bern 1994) Source Type: research

Tophaceuos Calcium Pyrophosphate Dihydrate Deposition Disease of the Temporomandibular Joint: The Preferential Site?
Calcium pyrophosphate dihydrate deposition disease (CPPD) is a metabolic disorder characterized by noninfectious joint inflammation with intra- or periarticular calcification. In 1962, Kohn et al were the first to describe the association of CPPD crystals in the synovial fluid of the knees of patients with cartilage calcifications visible on standard radiographs, termed “chondrocalcinosis,” and acute symptoms commonly associated with gout. Most population-based research uses chondrocalcinosis as the basis for the presence of CPPD, and this is strongly associated with an increase in age. Of the patients older than 60 ye...
Source: Journal of Oral and Maxillofacial Surgery - August 22, 2011 Category: ENT & OMF Authors: Daniel Zweifel, Dominik Ettlin, Bernhard Schuknecht, Joachim Obwegeser Tags: Anesthesia/Facial Pain Source Type: research

A case of destructive calcium pyrophosphate dihydrate crystal deposition disease of the temporomandibular joint: a diagnostic challenge
Abstract: The authors present the case of a 64-year-old woman with a destructive calcium pyrophosphate dihydrate (CPPD) crystal deposition disease of the temporomandibular joint. Progressive pain, swelling and a malocclusion were her chief complaints. A few granular calcified masses surrounding the left condylar head and extending to the infratemporal fossa and middle cranial base were presented in CT images. It occurred alone without other joints being affected. A provisional diagnosis of occupying lesion with invasion was made preoperatively, but histologically, the mass contained numerous deposits of rod-shaped or rhomb...
Source: International Journal of Oral and Maxillofacial Surgery - June 15, 2011 Category: ENT & OMF Authors: J. Meng, C. Guo, H. Luo, S. Chen, X. Ma Tags: Case Reports Source Type: research

Coincidence of calcium pyrophosphate and monosodium urate crystals in the synovial fluid of patients with gout determined by the cytocentrifugation technique
Monosodium urate (MSU) crystals are pathognomonic for gout, whereas calcium pyrophosphate dihydrate crystals (CPPD) are the typical morphological substrate of chondrocalcinosis (CC).1 2 CC is frequently associated with osteoarthritis (OA) but does not appear to cause advanced cartilage damage.3 The clinical implication of CPPD crystal deposition in OA is still unknown.4 Furthermore, it has been shown that OA predisposes to the formation of MSU crystals at the osteoarthritic joint site.5 In a previous retrospective trial without the use of cytoconcentration techniques, a coincidence of MSU and CPPD crystals was found in 17/...
Source: Annals of the Rheumatic Diseases - May 1, 2011 Category: Rheumatology Authors: Robier, C., Neubauer, M., Quehenberger, F., Rainer, F. Tags: Letters Source Type: research

Monoarticular pseudogout of the hip presenting as septic arthritis: a case report.
We present a case of monoarticular pseudogout of the hip joint whose symptoms mimicked septic arthritis. The definitive diagnosis was only confirmed after the microscopic analysis of joint aspirate. PMID: 21765235 [PubMed - as supplied by publisher] (Source: Acta Orthopaedica et Traumatologica Turcica)
Source: Acta Orthopaedica et Traumatologica Turcica - April 30, 2011 Category: Orthopaedics Authors: Mukhopadhyay S, Guha A, Perera A Tags: Acta Orthop Traumatol Turc Source Type: research

Ankylosing Spondylitis, Late Osteoarthritis, Vascular Calcification, Chondrocalcinosis and Pseudo Gout: Toward a Possible Drug Therapy.
In this review we consider diseases associated with pathological mineralization/ossification, namely, ankylosing spondylitis (AS), osteoarthritis (OA), generalized artery calcification of infancy (GACI), vascular calcification as well as chondrocalcinosis (CC) and pseudo gout. Deciphering the key enzymes implicated in the calcification process is an objective of prime importance and the ultimate goal is to synthesize inhibitors of these enzymes in order to provide efficient alternate therapeutic strategies that will slow down the pathologic mineralization and complement the arsenal of anti-inflammatory drugs. One of th...
Source: Current Medicinal Chemistry - April 25, 2011 Category: Chemistry Authors: Mebarek S, Hamade E, Thouverey C, Bandorowicz-Pikula J, Pikula S, Magne D, Buchet R Tags: Curr Med Chem Source Type: research

Calcifications in human osteoarthritic articular cartilage: ex vivo assessment of calcium compounds using XANES spectroscopy
Calcium (Ca2+)-containing crystals (CCs), including basic Ca2+ phosphate (BCP) and Ca2+ pyrophosphate dihydrate (CPPD) crystals, are associated with severe forms of osteoarthritis (OA). Growing evidence supports a role for abnormal articular cartilage mineralization in the pathogenesis of OA. However, the role of Ca2+ compounds in this mineralization process remains poorly understood. Six patients, who underwent total knee joint replacement for primary OA, have been considered in this study. Cartilage from femoral condyles and tibial plateaus in the medial and lateral compartments was collected as 1 mm-thick slices cut t...
Source: Journal of Synchrotron Radiation - April 8, 2011 Category: Physics Authors: Nguyen, C.Ea, H.K.Thiaudiere, D.Reguer, S.Hannouche, D.Daudon, M.lioté, F.Bazin, D. Tags: calcium-containing crystals cartilage osteoarthritis Fourier-transform infrared spectroscopy X-ray absorption spectroscopy research papers Source Type: research

European League Against Rheumatism recommendations for calcium pyrophosphate deposition. Part I: terminology and diagnosis
Conclusion New terms for CPPD were agreed and 11 key recommendations for diagnosis of CPPD were developed using research evidence and expert consensus. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - March 2, 2011 Category: Rheumatology Authors: Zhang, W., Doherty, M., Bardin, T., Barskova, V., Guerne, P.-A., Jansen, T. L., Leeb, B. F., Perez-Ruiz, F., Pimentao, J., Punzi, L., Richette, P., Sivera, F., Uhlig, T., Watt, I., Pascual, E. Tags: Radiology, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Clinical diagnostic tests, Radiology (diagnostics) Recommendations Source Type: research

EULAR recommendations for calcium pyrophosphate deposition. Part II: Management
Conclusion Nine key recommendations for management of CPP crystal associated arthritis were developed using both research evidence and expert consensus. Strength of recommendations was provided to assist the application of these recommendations. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - March 2, 2011 Category: Rheumatology Authors: Zhang, W., Doherty, M., Pascual, E., Barskova, V., Guerne, P.-A., Jansen, T. L., Leeb, B. F., Perez-Ruiz, F., Pimentao, J., Punzi, L., Richette, P., Sivera, F., Uhlig, T., Watt, I., Bardin, T. Tags: Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes Recommendations Source Type: research

Diagnosis of Calcium Pyrophosphate Dihydrate Deposition Disease by Fine Needle Aspiration Biopsy
Acta Cytologica 2002;46:46-49 (DOI:10.1159/000326715) (Source: Karger Publishers)
Source: Karger Publishers - February 24, 2011 Category: Cancer & Oncology Source Type: research

Pseudogout of the acromioclavicular joint: report of two cases and review of the literature
We describe two cases of acute pseudogout attacks of the AC joint in elderly patients. Radiological findings showed chondrocalcinosis in the AC joints. Microscopically, aspirated articular synovial fluid demonstrated CPPD crystals. Conservative therapy with non-steroidal anti-inflammatory drugs completely resolved all symptoms within 1 week. Content Type Journal ArticlePages 1-4DOI 10.1007/s10165-011-0417-8Authors Michiyuki Hakozaki, Department of Orthopaedic Surgery, Fukushima Prefectural Minami-Aizu Hospital, 14-1 Kazashita, Nagata, Minami-Aizu-machi, Fukushima 967-0006, JapanShinichi Kikuchi, Department o...
Source: Modern Rheumatology - February 5, 2011 Category: Rheumatology Tags: Modern Rheumatology Source Type: research

Slac wrist in the absence of recognised trauma and cppd.
Conclusions: This study suggests that non-traumatic SLAC does exist. We believe that non-traumatic SLAC begins with abnormal wrist kinematics and that the dorsal radiolunate ligament restricts lunate flexion but not scaphoid flexion, leading to increased SL angles and, with years, eventual attrition of the SL ligament. Type of Study/Level of Evidence: Prognostic, Level IV. PMID: 21089194 [PubMed - as supplied by publisher] (Source: Hand Surgery)
Source: Hand Surgery - November 24, 2010 Category: Surgery Authors: Pollock J, Giachino AA, Rakhra K, Diprimio G, Hrushowy H, Conway AF, Andreyechen M Tags: Hand Surg Source Type: research

Preface: Rheumatic Manifestations of Endocrine Disease
Rheumatologists in the clinic are faced with different presentations of various musculoskeletal complaints every day. Every new patient encounter requires the differential diagnosis of these complaints. The first task is usually to decide with what disease in Internal Medicine these complaints are associated. The endocrinopathies are a group of illnesses that either present initially or exhibit sometime during the course of the disease as a variety of musculoskeletal complaints. Rheumatic manifestations may often be the initial presentation of an endocrine disorder. Each endocrine disorder may also have its own arthritic c...
Source: Rheumatic Disease Clinics of North America - October 31, 2010 Category: Rheumatology Authors: Joseph A. Markenson Source Type: research

Gout and coexisting pseudogout in the knee joint
Conclusions Our findings suggest that the coexistence of gout and pseudogout should be considered in the diagnosis of crystal-induced arthritis. Careful crystal evaluation using compensated polarized microscopy may reveal similar cases with MSU and CPPD crystals in the same joint. Content Type Journal ArticleDOI 10.1007/s00167-010-1236-8Authors Yonsik Yoo, Center for Arthroscopy, Department of Orthopaedic Surgery, Hallym University Hangang Sacred Heart Hospital, 94-200 Youngdeungpo-Dong, Youngdeungpo-Ku, 150-719 Seoul, KoreaYoung-Jin Seo, Center for Arthroscopy, Department of Orthopaedic Surgery, Ha...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - August 27, 2010 Category: Orthopaedics Tags: Knee Surgery, Sports Traumatology, Arthroscopy Source Type: research

Diagnostic Guidelines Issued for CPPD Disorders
Calcium pyrophosphate deposition is a common musculoskeletal condition and the cause of calcium pyrophosphate arthropathy, the third most common inflammatory arthritis. The condition can be diagnosed definitively through the identification of CPP crystals in the synovial fluid by using joint fluid analysis, according to new diagnostic guidelines for the condition. (Source: Rheumatology News)
Source: Rheumatology News - June 30, 2010 Category: Rheumatology Authors: DIANA MAHONEY Tags: News Source Type: research

CPPD crystal deposition disease of the cervical spine: A common cause of acute neck pain encountered in the neurology department
Conclusions: CPPD crystal deposition disease of the cervical spine is one of the most common underrecognized causes of acute neck pain in the neurology department, especially in elderly patients. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - June 20, 2010 Category: Neurology Authors: Yoshiki Sekijima, Takuhiro Yoshida, Shu-ichi Ikeda Tags: Original Articles Source Type: research

EULAR: First Set of CPPD Guidelines Outlined (CME/CE)
ROME (MedPage Today) -- New recommendations for the management of calcium pyrophosphate deposition (CPPD), an illness manifested by swollen joints and often misdiagnosed as gouty arthritis, were presented here by a guideline development group of the European League Against Rheumatism. (Source: MedPage Today Meeting Coverage)
Source: MedPage Today Meeting Coverage - June 19, 2010 Category: Journals (General) Source Type: news

Calcium pyrophosphate dihydrate deposition disease of the spleen
Abstract: Calcium pyrophosphate dihydrate deposition disease (CPPD), also known as pseudogout or chondrocalcinosis, is a variety of metabolic arthropathy caused by the deposition of calcium pyrophosphate dihydrate crystals in and around joints. Despite many case reports, extra-articular CPPD often goes unrecognized. Here, we report a unique case of pancreatic tail pseudocyst and CPPD of the spleen. To the best of our knowledge, CPPD of the spleen has not been reported in the literature. (Source: American Journal of Surgery)
Source: American Journal of Surgery - June 9, 2010 Category: Surgery Authors: Yuan-Chun Hsu, Chen-Wang Chang, Chun-Lu Lin, Chuan-Tsai Lai Tags: Clinical Images Source Type: research

Gitelman syndrome, calcium pyrophosphate dihydrate deposition disease and crowned dens syndrome. A new association?
(Source: Rheumatology)
Source: Rheumatology - February 11, 2010 Category: Rheumatology Authors: Gutierrez, M., Silveri, F., Bertolazzi, C., Salaffi, F., Giacchetti, G., Girolimetti, R., Filippucci, E., Grassi, W. Tags: Crystal Arthritis CASE REPORTS Source Type: research

Cervical myelopathy from calcium pyrophosphate dihydrate crystal deposition: a case report
We present a 56-year-old man with spinal stenosis secondary to CPPD disease and subacute cervical myelopathy following minor trauma. The patient had no history of CPPD disease. Posterior C4-C6 decompression and instrumented fusion were performed. Intraoperative findings were densely thickened ligamentum flavum and distortion of the cervical dura mater due to impingement. Histological sections of discs and ligamentum flavum specimens showed CPPD crystals. Postoperatively, neck pain and paresthesias improved immediately. At 2 weeks after spinal surgery, the patient experienced acute right knee swelling. Standard ra...
Source: European Journal of Orthopaedic Surgery & Traumatology - February 2, 2010 Category: Orthopaedics Tags: European Journal of Orthopaedic Surgery & Traumatology Source Type: research

Articular cartilage mineralization in osteoarthritis of the hip
Conclusions: Articular cartilage calcification is a common event in osteoarthritis of the hip. The amount of calcification correlates with clinical symptoms and histological OA grade. (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - December 28, 2009 Category: Orthopaedics Authors: Martin FuerstOliver NiggemeyerLydia LammersFritz SchaferChristoph LohmannWolfgang Ruther Source Type: research

Mercaptopyruvate Inhibits Tissue-Nonspecific Alkaline Phosphatase and Calcium Pyrophosphate Dihydrate Crystal Dissolution.
CONCLUSION: Endogenous amino acids like cysteine and its derivative MPA have the capacity to inhibit TNAP activities at physiologic concentrations. Downregulation of their inhibiting concentration in the cartilage interstitial fluid environment may provide a therapeutic avenue to controlled dissolution of CPPD crystal deposition in tissues. PMID: 19884277 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 1, 2009 Category: Rheumatology Authors: Kannampuzha JV, Tupy JH, Pritzker KP Tags: J Rheumatol Source Type: research

An Idiopathic Case of Calcium Pyrophosphate Dihydrate Crystal Deposition Disease with Crowned Dens Syndrome in a Young Patient.
We report a case with severe idiopathic CPPD crystal deposition disease including crowned dens syndrome in the cervical spine.Page: 949DOI: 10.1097/SMJ.0b013e3181b08c26Authors: Unlu, Zeliha MD; Tarhan, Serdar MD; Ozmen, Eylem Mete MD (Source: Southern Medical Journal)
Source: Southern Medical Journal - September 15, 2009 Category: Journals (General) Tags: Abstract HTML PDF (359 K) Source Type: research

Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis [Clinical and epidemiological research]
Conclusions: IL1 inhibition both prevented and relieved pain and ankle joint inflammation in response to intra-articular MSU crystals in mice. Results suggested that IL1 Trap has the potential to both prevent and treat gouty arthritis. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - September 11, 2009 Category: Rheumatology Authors: Torres, R, Macdonald, L, Croll, S D, Reinhardt, J, Dore, A, Stevens, S, Hylton, D M, Rudge, J S, Liu-Bryan, R, Terkeltaub, R A, Yancopoulos, G D, Murphy, A J Tags: Editor's choice, Genetics, Immunology (including allergy), Pain (neurology), Inflammation, Degenerative joint disease, Musculoskeletal syndromes Clinical and epidemiological research Source Type: research