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Early FDG-PET/CT scans may help direct head and neck cancer therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Changes in standardized uptake values on FDG-PET/CT scans may be "significantly (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 20, 2009 Category: Radiology Source Type: info

The Comparison of Clinical Effect of Rh-endostar on Retreated Non-Small Cell Lung Cancer and Colorectal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The clinical efficacy of rh-endostatin on retreated colorectal cancer was better than on retreated non-small cell lung cancer, which suggested that it was necessary to perform more clinical observations on the digestive tumors. (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Promising New Cancer Drugs in the PipelineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A number of novel and promising cancer therapies are currently in the pipeline, and researchers might be discovering new uses for older drugs. Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - November 19, 2009 Category: Internal Medicine Tags: Hematology-Oncology Source Type: info

Core/shell pH-sensitive micelles self-assembled from cholesterol conjugated oligopeptides for anticancer drug deliveryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A doxorubicin (DOX) delivery system of pH-sensitive micelles self-assembled from cholesterol conjugated His5Arg10 (HR15-Chol) and His10Arg10 (HR20-Chol) has been described in this article. The amphiphilic molecules have low critical micelle concentrations of 17.8 and 28.2 [mu]g/mL for HR15-Chol and HR20-Chol, respectively, even at a low pH of 5.0. The pH-sensitive histidine segment of the polypeptide block is insoluble at pH 7.4 but becomes positively charged and soluble via protonation at pH lower than 6.0. The size and zeta potential of DOX-loaded micelles increases with the decrease in pH. Coarse-grained simulations wer...
Source: AIChE Journal - November 19, 2009 Category: Science Authors: Xin Dong Guo, Li Juan Zhang, Yun Chen, Yu Qian Source Type: journals

Review: Personalised cancer therapy with selective kinase inhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: J Clin Oncol Area: News In this review, the authors summarise recent developments in personalised cancer therapy with selective kinase inhibitors under the following headings: . Genomic heterogeneity in cancer and the response to drug therapy . Targeting kinases in cancer therapy . Mutationally activated kinases and the clinical response to kinase-targeted therapeutics . Genotype-directed kinase inhibition: the case of epidermal growth factor receptor mutations in lung cancer . Expanding the domain of genotype-associated response to ki...
Source: NeLM - Oncology - November 19, 2009 Category: Cancer & Oncology Source Type: organizations

Laparoscopic splenectomy may be a superior supportive intervention for cirrhotic patients with hypersplenismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Laparoscopic splenectomy may be superior to partial splenic embolization as a supportive intervention for cirrhotic patients with hypersplenism. Future prospective, randomized controlled patient studies are required to confirm these findings. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Morimasa Tomikawa, Tomohiko Akahoshi, Keishi Sugimachi, Yasuharu Ikeda, Kisaku Yoshida, Yuichi Tanabe, Hirofumi Kawanaka, Kenji Takenaka, Makoto Hashizume, Yoshihiko Maehara Source Type: journals

Personalized Cancer Therapy With Selective Kinase Inhibitors: An Emerging Paradigm in Medical Oncology [BIOLOGY OF NEOPLASIA]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Selective kinase inhibitors have emerged as an important class of anticancer agents, with demonstrated clinical efficacy and generally favorable toxicity profiles in several common disease settings where conventional treatments have previously provided only modest benefit. Consequently, a substantial effort is now underway to identify additional therapeutically relevant kinase targets and to develop and test inhibitors of those proteins in a variety of human malignancies. However, it has also become clear that the clinical benefit associated with these agents is typically limited to a subset of treated patients, who in man...
Source: Journal of Clinical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: McDermott, Settleman Tags: Signal Transduction, Cancer Biomarkers, Oncogenes BIOLOGY OF NEOPLASIA Source Type: journals

Association of Molecular Markers With Toxicity Outcomes in a Randomized Trial of Chemotherapy for Advanced Colorectal Cancer: The FOCUS Trial [Gastrointestinal Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results do not support the routine clinical use of the evaluated polymorphisms, including UGT1A1*28. Further investigation of XRCC1, ERCC2, and GSTP1 as potential predictors of irinotecan toxicity is warranted. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Braun, Richman, Thompson, Daly, Meade, Adlard, Allan, Parmar, Quirke, Seymour Tags: Clinical Trials, Chemotherapy, Translational Oncology, Gastrointestinal, Cancer Biomarkers Gastrointestinal Cancer Source Type: journals

Conference: MRI, NMR detect early cancer treatment responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BOSTON--Novel targeted cancer therapies could benefit from MRI and spectroscopy in obtaining an early indication of efficacy of the drug and in guiding personalized medicine, according to a presentation on Tuesday at AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics conference. (Source: Health Imaging News)
Source: Health Imaging News - November 18, 2009 Category: Radiology Tags: Latest News Source Type: news

Suzanne Somers speaks out against the conventional cancer industry: mammograms, chemotherapy vs. alternative curesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) As the author of the New York Times bestseller, "Knockout: Interviews with doctors who are curing cancer," Suzanne Somers is making waves across the cancer industry. Her powerful, inspired message of informed hope is reaching millions of readers who are learning about the many safe, effective options for treating cancer that exist outside the realm of the conventional cancer industry (chemotherapy, surgery and radiation).Recently, Suzanne Somers spoke with NaturalNews editor Mike Adams, the Health Ranger, to share the inspiration for her new book Knockout. "People are just starving for some new information......
Source: NaturalNews.com - November 18, 2009 Category: Consumer Health Advice Source Type: news

New Guidelines Developed for Lung Cancer TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The American Society of Clinical Oncology updated guidelines for chemotherapy and biologic therapy for stage IV non-small cell lung cancer were published online Nov. 16 in the Journal of Clinical Oncology. (Source: Modern Medicine)
Source: Modern Medicine - November 18, 2009 Category: Journals (General) Source Type: info

A powerful combination punch against breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A powerful new breast cancer therapy could result from packaging one of the newer drugs that inhibits cancer's hallmark wild growth with another that blocks a primordial survival technique in which the cancer cell eats part of itself, scientists say. While they are powerful killers of some breast cancer cells, new drugs called histone deacetylase inhibitors, or HDAC inhibitors, also increase self-digestion, or autophagy, in surviving, mega-stressed cells, Medical College of Georgia Cancer Center scientists reported during the Molecular Targets and Cancer Therapeutics International Conference this week in Boston. The confer...
Source: Medicineworld.org: New Article Alert - November 17, 2009 Category: Consumer Health News Source Type: info

Scientists Release New Data On Endometrial Cancer TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current study results from the report, 'A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcoma,' have been published. According to a study from the United Kingdom, Platinum compounds, taxanes and anthracyclines provide the major effective drug classes in the treatment of advanced and recurrent endometrial cancer and carcinosarcoma. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news

PrefaceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The randomized clinical trial (RCT) is the gold standard for proving the relative value of a medical intervention. Patients are assigned randomly by chance to different therapies so that the investigator cannot select patients for one particular treatment arm. Randomization also tends to distribute known, prognostic factors (as well as those that are unrecognized) equally between or among the study arms. Currently, there are over 350 active phase 3 trials in cancer therapy in the United States (http://www.cancer.gov). (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Adam C. Yopp, Ronald P. DeMatteo Source Type: journals

p53-based Anti-cancer Therapies: an Empty Promise?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since its discovery in 1979, p53 has become the focus of intensive cancer-based research in laboratories around the world. The p53 protein mediates critical cellular functions including the response to genotoxic stress, differentiation, senescence, and apoptosis, and has been shown to be mutated in a large proportion of human cancers. These observations led many to speculate that targeting the p53 pathway would result in the development of successful anti-cancer treatments. In spite of this, 30 years later, p53 has yet to fulfill this promise. However, new insights into small molecule combination therapies, microRNA re...
Source: Current Issues in Molecular Biology - November 16, 2009 Category: Molecular Biology Authors: Desilet N, Campbell TN, Choy FY Tags: Curr Issues Mol Biol Source Type: journals

Ideal nanoparticle cancer therapies surf the bloodstreamEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers are studying blood using computer models that simulate how the fluid and the cells it contains move around. One new study shows how components in blood line up to prepare for healing; another demonstrates the best shape to use for man-made nanoparticles that target cancers -- a surfboard. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 15, 2009 Category: Science Source Type: news

Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: ASAH1 is an estrogen-dependent member of the sphingolipid metabolism, which might provide further prognostic information in ER-positive breast cancers. PMID: 19905902 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Ruckhäberle E, Holtrich U, Engels K, Hanker L, Gätje R, Metzler D, Karn T, Kaufmann M, Rody A Tags: Climacteric Source Type: journals

Severe oral mucositis associated with cancer therapy: impact on oral functional status and quality of lifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Severe OM can cause profound pain and oral functional incapability and clinical significant impairment of QoL. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00520-009-0771-7Authors Karis Kin-Fong Cheng, The Chinese University of Hong Kong Faculty of Medicine, The Nethersole School of Nursing Room732, Esther Lee Building, Sha Tin Hong Kong N.T. ChinaS. F. Leung, Prince of Wales Hospital Department of Clinical Oncology Hong Kong N.T. ChinaRaymond H. S. Liang, The University of Hong Kong Division of Hematology, Medical Oncology and Bone Marrow transplantation, Faculty of Med...
Source: Supportive Care in Cancer - November 14, 2009 Category: Cancer & Oncology Tags: Supportive Care in Cancer Source Type: journals

Expression of IL-13Rα2 in liver cancer cells and its effect on targeted therapy of liver cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We reported the expression of IL-13Rα2 in liver cancer cell lines and tissues as well as investigated the cytotoxin (DT389-hIL13-13E13K) targeted killing efficiency of liver cancer cells and potential role of IL-13Rα2 in the cancer treatment. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0724-zAuthors Lingling Hou, Beijing Jiaotong University College of Life Sciences and Bioengineering 100044 Beijing People’s Republic of ChinaJuan Du, Beijing Jiaotong University College of Life Sciences and Bioengineering 100044 Beijing People’s Republic of ChinaJianwei Wan...
Source: Journal of Cancer Research and Clinical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Researchers From Harvard University Report Recent Findings In CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several components of the Writ signaling cascade have been shown to function either as tumor suppressor proteins or as oncogenes in multiple human cancers, underscoring the relevance of this pathway in oncogenesis and the need for further investigation of Wnt signaling components as potential targets for cancer therapy. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - November 14, 2009 Category: Cancer & Oncology Source Type: news

Macrophage migration inhibitory factor expression in cervical cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions MIF has been shown to promote tumor immune escape mechanisms in other cancer entities, which makes it an interesting target for cancer therapy, given the known significance of immune mechanisms for uterine cervical cancer. The overexpression of MIF on the protein and mRNA level, as well as its secretion by cervical cancer cells points to a critical role of the protein for the pathogenesis of uterine cervical cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0702-5Authors Mathias Krockenberger, University of Wuerzburg Department of Obstetrics and Gynecology ...
Source: Journal of Cancer Research and Clinical Oncology - November 13, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

NanoSystems Institute at UCLA to host global symposium on nanobiotechnologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WHAT: Nanotechnology has shown great promise for applications in the areas of energy, information technology and the environment. In the health and medicine fields, however, its promise has progressed beyond possibility to become reality. Nanoscale research has led to techniques and devices with the potential to revolutionize health care, including imaging tools that detect cancers at the atomic level, nanomachines programmed to release drugs within specific cells, and biosensors that monitor changes from deep within body organs. The impact of these and other developments on the current state of medicine and thei...
Source: UCLA Newsroom: Health Sciences - November 13, 2009 Category: Universities & Medical Training Source Type: organizations

Prostate cancer and its treatment with Iscucin®Populi—Introduction and case reports: der Merkurstab, Heft 3, 2009, pp. 255–261Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Since prostate cancer is the most frequently diagnosed malignancy among males, the treatment of this disease becomes more and more important. A number of well-established forms of treatment are available in conventional medicine. These treatments are effective, but patients often suffer from considerable side effects (particularly concerning their sexuality), leading to an increased interest in complementary treatments.Objectives: Misteltoe therapy is a frequently applied complementary treatment in oncological practice, however, the state of knowledge regarding misteltoe therapy in prostate cancer is so far lim...
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: R. Kempenich, U. Meyer, M. Willeke Source Type: journals

Strengthening self-healing—Integrative approaches to cancer therapy with mind/body medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cancer patients often perceive themselves as radically injured in their capacities to self-regulate their health and well being. Their mind literally feels betrayed by their bodies. This condition of hopelessness diminishes their self-efficacy and greatly adds to their suffering. At the Clinic for Naturopathy and Integrative Medicine in Essen we have developed an 11-week outpatient program in Mind/Body Medicine that empowers patients to regain responsibility for their own well being. In addition to their conventional therapies patients learn to use self-help strategies like regular exercise and a healthy diet as well as re...
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: A. Paul Source Type: journals

A pharmacokinetic and safety study of intravenous arsenic trioxide in adult cancer patients with renal impairmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Renal impairment did increase the systemic exposure to arsenic and its methylated metabolites following standard daily dosing of arsenic trioxide. The data from the limited number of patients with severe renal dysfunction did not suggest that severe renal impairment affected the safety profile of arsenic trioxide in cancer patients who received limited treatment with arsenic trioxide. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1169-4Authors Christopher J. Sweeney, Indiana University Department of Medicine 535 Barnhill Drive, Rm 473 Indianapolis IN 46202 USA...
Source: Cancer Chemotherapy and Pharmacology - November 12, 2009 Category: Cancer & Oncology Tags: Cancer Chemotherapy and Pharmacology Source Type: journals

Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we sought to examine the prognostic relevance of ALDH1, a putative cancer stem cell marker, by immunohistochemistry. The four cohorts analyzed included an adjuvantly treated series of 245 invasive cancers, a neoadjuvantly treated series of 34 cases, and two series of 58 and 40 triple negative cases, respectively. Both tumor cell and stromal expression for ALDH1 was evaluated, where possible. Tumor cell ALDH1 expression significantly correlated only with basal-like and HER2 tumor types in the adjuvant series and tumor grade in the neoadjuvant cohort. No significant enrichment for ALDH1 positive cells was...
Source: Breast Cancer Research and Treatment - November 12, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals

Survivorship: Childhood Cancer SurvivorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Long-term survivors of childhood and adolescent cancer are a high-risk population of patients who often seek acute or preventive health care with a primary care clinician. Of importance is that the curative therapy administered for the cancer also affects growing and developing organ systems. Following chemotherapy, radiotherapy, and surgery, many survivors will experience chronic or late-occurring health problems, often not becoming clinically apparent until decades after therapy. Survivors face an increase in risk of serious morbidity, premature mortality, and diminished health status associated with their previous cance...
Source: Primary Care: Clinics in Office Practice - November 12, 2009 Category: Primary Care Authors: Kevin C. Oeffinger, Melissa M. Hudson, Wendy Landier Source Type: journals

Correction: RLIP76: A Target for Kidney Cancer TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cancer Research)
Source: Cancer Research - November 12, 2009 Category: Cancer & Oncology Tags: Corrections Source Type: journals

Inhibition of Lipocalin 2 Impairs Breast Tumorigenesis and MetastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lipocalin 2 (LCN2; also known as NGAL) is a secreted glycoprotein and its elevated expression has been observed in breast cancers. However, the importance of LCN2 in breast tumorigenesis is unclear. Here, we employed a spontaneous mammary tumor mouse model showing that MMTV-ErbB2(V664E) mice lacking mouse LCN2 had significantly delayed mammary tumor formation and metastasis with reduced matrix metalloproteinase-9 activity in the blood. LCN2 expression is upregulated by HER2/phosphoinositide 3-kinase/AKT/NF-B pathway. Decreasing LCN2 expression significantly reduced the invasion and migration ability of HER2+ breast cancer ...
Source: Cancer Research - November 12, 2009 Category: Cancer & Oncology Authors: Leng, X., Ding, T., Lin, H., Wang, Y., Hu, L., Hu, J., Feig, B., Zhang, W., Pusztai, L., Symmans, W. F., Wu, Y., Arlinghaus, R. B. Tags: Cell, Tumor, and Stem Cell Biology Source Type: journals

Cytoplasmic mislocalization of the orphan nuclear receptor Nurr1 is a prognostic factor in bladder cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nurr1 belongs to a novel class of orphan nuclear receptors (the NR4A family). The authors have previously shown that Nurr1 is important in carcinogenesis. In the current study, they examined the clinicopathologic relevance of expression patterns of Nurr1 in bladder tumors.Nurr1 expression was determined using immunohistochemical staining in a bladder cancer tissue array (145 tumors). Tumors were classified according to Nurr1 protein levels in both cytoplasm and nucleus. Disease-specific survival and recurrence-free survival were investigated by Kaplan-Meier analysis and Cox proportional hazards analysis in multivariate mod...
Source: Cancer - November 12, 2009 Category: Cancer & Oncology Authors: Teruo Inamoto, Bogdan A. Czerniak, Colin P. Dinney, Ashish M. Kamat Source Type: journals

Cannabidiol Inhibits Cancer Cell Invasion Via Upregulation Of Tissue Inhibitor Of Matrix Metalloproteinases-1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although cannabinoids exhibit a broad variety of anticarcinogenic effects, their potential use in cancer therapy is limited by their psychoactive effects. Here we evaluated the impact of cannabidiol, a plant-derived non-psychoactive cannabinoid, on cancer cell invasion. Using Matrigel invasion assays we found a cannabidiol-driven impaired invasion of human cervical cancer (HeLa, C33A) and human lung cancer cells (A549) that was reversed by antagonists to both CB(1) and CB(2) receptors as well as to transient receptor potential vanilloid 1 (TRPV1). The decrease of invasion by cannabidiol appeared concomitantly with upre...
Source: Biochemical Pharmacology - November 12, 2009 Category: Drugs & Pharmacology Authors: Ramer R, Merkord J, Rohde H, Hinz B Tags: Biochem Pharmacol Source Type: journals

Intratumoral CD8+ T/FOXP3+ cell ratio is a predictive marker for survival in patients with colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, itCD8+ T/itFOXP3+ cell ratio is a predictive marker for both disease-free survival time and overall survival time in patients with colorectal cancer. Importantly, itCD8+ T/itFOXP3+ cell ratio may be an independent prognostic factor. And, tumor-producing TGF-β may contribute to the increased number of itFOXP3+ cells. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00262-009-0781-9Authors Hiroyuki Suzuki, Kyushu University Department of Cancer Therapy and Research, Graduate School of Medical Sciences 3-1-1 Maidashi, Higashi-Ku Fukuoka 812-8582 JapanNobuhito Chikazawa, Kyushu Universit...
Source: Cancer Immunology, Immunotherapy - November 11, 2009 Category: Cancer & Oncology Tags: Cancer Immunology, Immunotherapy Source Type: journals

Antibiotic Overuse Threatens Modern Medicine: ExpertsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Overuse of antibiotics in Europe is building widespread resistance and threatening to halt vital medical treatments such as hip replacements, intensive care for premature babies and cancer therapies, health experts say. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 11, 2009 Category: Consumer Health News Tags: Pharmacist Source Type: news

Sunitinib: A Multitargeted Receptor Tyrosine Kinase Inhibitor in the Era of Molecular Cancer TherapiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BioDrugs)
Source: BioDrugs - November 11, 2009 Category: Drugs & Pharmacology Authors: Papaetis, Georgios S.Syrigos, Kostas N. Tags: Review Articles Source Type: journals

Discovery in worms may lead to better cancer treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists at Queen's University have found a link between two genes involved in cancer formation in humans, by examining the genes in worms. The groundbreaking discovery provides a foundation for how tumor-forming genes interact, and may offer a drug target for cancer therapy. "When cancer hijacks a healthy system, it can create tumors by causing cells to divide when they shouldn't," says Ian Chin-Sang, a developmental biologist at Queen's and lead researcher on the study. "Certain genes control the normal movement and growth of cells, and by studying how these genes interact, we can understand what is abnormal when cance...
Source: Medicineworld.org: New Article Alert - November 11, 2009 Category: Consumer Health News Source Type: info

Data on Off-Label Targeted Cancer Drugs More Plentiful Than HelpfulEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Evidence within compendia to support the off-label use of targeted cancer therapies varies widely and is rapidly evolving, making it difficult to draw solid conclusions regarding safety and efficacy, according... (Source: OncologySTAT Latest News)
Source: OncologySTAT Latest News - November 11, 2009 Category: Cancer & Oncology Source Type: news

'Early days' for lung cancer drugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This early research has shown, for the first time, a large effect of a novel drug in reducing the growth of SCLC tumours in mice. This is early research, but its results are promising and will probably lead to much interest in this class of drugs. Some strengths of this study should be noted: The effect of the drug was dose-dependent, which means the more drug the researchers added to the cells, the less the cells proliferated. This makes it more likely that the drug has a direct effect on the cells. The combination of treatment and PET scanning in one study means that the response to the drug was tested i...
Source: NHS News Feed - November 11, 2009 Category: Consumer Health News Tags: Cancer Source Type: news

Reconsider screenings for breast and prostate cancer, experts sayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) According to the American Cancer Society (ACS), breast cancer is the most common cancer in women, affecting over 200,000 women in the U.S. each year and killing more than 40,000. For American men, cancer of the prostate is the type of malignancy that strikes with the greatest frequency.The ACS says an estimated 192,280 men will be diagnosed with the disease in 2009 and around 27,360 men will die from it. Based on the assumption that finding breast and prostate cancers in the earliest stages will make them easier to cure and slash mortality rates, for over twenty years the U.S. medical establishment has pushed...
Source: NaturalNews.com - November 11, 2009 Category: Consumer Health Advice Source Type: news

Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the proapoptotic protein Fem1b is downregulated by the proteasome in malignant colon cancer cells and mediates proteasome inhibitor-induced apoptosis of these cells. Therefore, Fem1b could represent a novel molecular target to overcome apoptosis resistance in therapy of colon cancer. © 2009 Wiley-Liss, Inc. (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - November 11, 2009 Category: Molecular Biology Authors: M. Cecilia Subauste, Owen J. Sansom, Nehal Porecha, Natacha Raich, Liqin Du, Joseph F. Maher Source Type: journals

Tissue-Selective Regulation of Aromatase Expression by Calcitriol: Implications for Breast Cancer Therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aromatase, the enzyme that catalyzes estrogen synthesis, is critical for the progression of estrogen receptor-positive breast cancer (BCa) in postmenopausal women. We show that calcitriol, the hormonally active form of vitamin D, regulates the expression of aromatase in a tissue-selective manner. Calcitriol significantly decreased aromatase expression in human BCa cells and adipocytes and caused substantial increases in human osteosarcoma cells (a bone cell model exhibiting osteoblast phenotype in culture) and modest increases in ovarian cancer cells. Calcitriol administration to immunocompromised mice bearing human BC...
Source: Endocrinology - November 11, 2009 Category: Endocrinology Authors: Krishnan AV, Swami S, Peng L, Wang J, Moreno J, Feldman D Tags: Endocrinology Source Type: journals

Targeted therapies in thyroid cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Differentiated thyroid carcinoma is the most frequent neoplasm of the endocrine system. Although thyroid cancer usually has an excellent prognosis, no therapeutic options are available for patients that develop metastases and are or became resistant to radioiodine therapy. The deeper knowledge of molecular aberrations that characterize tumor growth has provided novel targets in cancer therapy. Several proteins have been implicated as having a crucial role in the carcinogenesis of differentiated thyroid cancer, such as those involved in RET/PTC-RAS-RAF-MAPK pathway. Moreover, vascular aberrations and...
Source: Targeted Oncology - November 10, 2009 Category: Cancer & Oncology Tags: Targeted Oncology Source Type: journals

Urokinase plasminogen activator system as a potential target for cancer therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Future Oncology , November 2009, Vol. 5, No. 9, Pages 1487-1499. (Source: Future Oncology)
Source: Future Oncology - November 10, 2009 Category: Cancer & Oncology Tags: article Source Type: journals

Ideal Nanoparticle Cancer Therapies Surf The BloodstreamEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eric Shaqfeh studies blood at Stanford University, using computer models that simulate how the fluid and the cells it contains move around. On November 11 at a meeting of the scientific society AVS, he will present his latest unpublished findings from two studies. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 10, 2009 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Ideal Nanoparticle Cancer Therapies Surf The BloodstreamEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eric Shaqfeh studies blood at Stanford University, using computer models that simulate how the fluid and the cells it contains move around. On November 11 at a meeting of the scientific society AVS, he will present his latest unpublished findings from two studies. One shows how components in blood line up to prepare for healing; the other demonstrates the best shape to use for man-made nanoparticles that target cancers -- a surfboard. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 10, 2009 Category: Cancer & Oncology Tags: Cancer / Oncology Source Type: news

Antibiotic overuse threatens modern medicine: expertsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
LONDON (Reuters) - Overuse of antibiotics in Europe is building widespread resistance and threatening to halt vital medical treatments such as hip replacements, intensive care for premature babies and cancer therapies, health experts say. (Source: Reuters: Health)
Source: Reuters: Health - November 10, 2009 Category: Consumer Health News Tags: healthNews Source Type: news

Molecular Targets And Cancer Therapeutics International ConferenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists and industry leaders from around the world will gather in Boston Nov. 14-19, 2009, for the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International Conference, which will feature groundbreaking information on important cancer therapies in development. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 10, 2009 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Molecular Targets And Cancer Therapeutics International ConferenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists and industry leaders from around the world will gather in Boston Nov. 14-19, 2009, for the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International Conference, which will feature groundbreaking information on important cancer therapies in development. "Cancer is a complex disease and to treat it effectively we need a greater understanding of the activity that takes place at the molecular level," said Lewis Cantley, Ph.D. (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - November 10, 2009 Category: Biochemistry Tags: Cancer / Oncology Source Type: news

AACR, NCI And EORTC To Host Molecular Targets And Cancer Therapeutics International ConferenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists and industry leaders from around the world will gather in Boston Nov. 14-19, 2009, for the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International Conference, which will feature groundbreaking information on important cancer therapies in development. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 10, 2009 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

AACR, NCI And EORTC To Host Molecular Targets And Cancer Therapeutics International ConferenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists and industry leaders from around the world will gather in Boston Nov. 14-19, 2009, for the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International Conference, which will feature groundbreaking information on important cancer therapies in development. "Cancer is a complex disease and to treat it effectively we need a greater understanding of the activity that takes place at the molecular level," said Lewis Cantley, Ph.D. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 10, 2009 Category: Cancer & Oncology Tags: Cancer / Oncology Source Type: news