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[Multiple primary neoplasms - coincidence or tumor syndrom?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the history of an actually asymptomatic female patient with four different malignancies within 30 years: malignant melanoma (1976), liposarcoma (1983), carcinoma of the appendix (2006) and lymphoma (2006). Discussion: There is not only a remarkable variety of malignant tumors but also an extraordinary long survival without recurrence of the generalised malignomas of the skin and soft tissue (malignant melanoma and liposarcoma). It is difficult to explain the entire restitution with the implemented treatments (several tumor resections, chemotherapy with Ifosfamide). More than 20 years after chemotherapy, the lymp...
Source: Praxis - September 8, 2009 Category: Journals (General) Authors: Schrofer C, Villiger P, Cathomas R Tags: Praxis (Bern 1994) Source Type: journals

Incidence, Risk Factors, and Impact of Severe Neutropenia After Hyperthermic Intraperitoneal Mitomycin CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Neutropenia is a frequent complication associated with MMC-HIPEC. Female sex and MMC dose per BSA are independent risk factors for neutropenia. These differences must be considered in the management of patients undergoing MMC-HIPEC to minimize the toxicity of the procedure. Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-009-0523-4Authors Laura A. Lambert, The University of Texas M.D. Anderson Cancer Center Department of Surgical Oncology Houston TX USATerri S. Armstrong, University of Texas–Houston School of Nursing Houston TX USAJ. Jack Lee, The Universi...
Source: Annals of Surgical Oncology - May 28, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Epithelial Appendiceal Neoplasms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The appendiceal malignancies usually arise within a mucocele. The tumor within this structure can be minimally aggressive or of an invasive character. If a low-grade appendiceal malignancy is removed intact, recurrence does not occur. If rupture of the wall of the mucocele occurs with either low-grade or high-grade disease, the epithelial cells within will disseminate to the peritoneal surfaces. Sometimes a second-look surgery must be performed to determine if intraperitoneal spread of mucus and cancer cells has occurred. If the diagnosis of peritoneal dissemination of an appendiceal malignancy has been established, a ...
Source: Cancer Journal - April 30, 2009 Category: Cancer & Oncology Authors: Sugarbaker PH Tags: Cancer J Source Type: journals

The Current Role of Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Dissemination of Appendiceal TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Appendiceal malignancies are rare with an age-adjusted incidence of about 0.12 cases per 1 million individuals per year. Appendiceal tumors are infrequently diagnosed before surgery and often present with peritoneal dissemination. In cases with low-grade cytology, this peritoneal dissemination is hypothesized to arise from perforation of the appendiceal tumor and subsequent dissemination of mucous-producing adenomatous epithelial cells throughout the abdomen and pelvis. This may lead to mucinous ascites or pseudomyxoma peritonei (PMP). In cases with high-grade cytology, the peritoneal dissemination is usually seen in assoc...
Source: Current Problems in Cancer - April 30, 2009 Category: Cancer & Oncology Authors: John H. Stewart, Edward A. Levine, Perry Shen Source Type: journals

Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: Report of a caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of appendiceal adenocarcinoma manifesting as a colonic obstruction with a lower abdominal mass. Laparotomy revealed bilateral ovarian tumors and a small appendiceal tumor with peritoneal metastases. We performed ileocecal resection, colectomy, and oophorectomy, following which a histological diagnosis of signet ring cell carcinoma was made. Immunohistochemical analysis revealed positive expression of cytokeratin 7 and 20, and mucin core protein 2 (MUC2), compatible with appendiceal cancer and Kruckenberg metastases. When a patient is found to have disseminated pelvic signet ring cell carcinoma of unkn...
Source: Surgery Today - March 12, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Peritoneal carcinomatosis: patients selection, perioperative complications and quality of life related to cytoreductive surgery and hyperthermic intraperitoneal chemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide a promising combined treatment strategy for selected patients with peritoneal carcinomatosis that can improve patient survival and quality of life. The extent of intraperitoneal tumor dissemination and the completeness of cytoreduction are the leading predictors of postoperative patient outcome. Thus, consistent preoperative diagnostics and patient selection are crucial to obtain a complete macroscopic cytoreduction (CCR-0/1). (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - January 8, 2009 Category: Cancer & Oncology Authors: Gabriel Glockzin, Hans J Schlitt and Pompiliu Piso Source Type: journals

Early carcinoma of the appendix vermiformisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is difficult to preoperatively diagnose early carcinoma of the vermiform appendix because of its rarity and few specific clinical features. In the present study, we report a preoperatively diagnosed mucosal carcinoma of the vermiform appendix. (Source: Digestive Endoscopy)
Source: Digestive Endoscopy - December 22, 2008 Category: Gastroenterology Authors: Shingo Oya, Kanji Miyata, Norihiro Yuasa, Eiji Takeuchi, Yasutomo Goto, Hideo Miyake, Keiichi Nagasawa, Yoichiro Kobayashi, Terutomo Ito, Masafumi Ito Tags: ENDOSCOPIC IMAGES OF INTEREST Source Type: journals

Adenocarcinoma of the Appendix Is Rarely Detected by ColonoscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Appendiceal abnormalities are infrequently seen on colonoscopy and rarely yield a diagnostic biopsy in patients with appendiceal carcinoma. We found that nearly 42% of patients with carcinoma of the appendix have synchronous colonic polyps, a much higher prevalence than would be expected, supporting a role for a perioperative colonoscopy. Content Type Journal ArticleDOI 10.1007/s11605-008-0774-6Authors Apurva N. Trivedi, Wake Forest University Baptist Medical Center Section of Gastroenterology Medical Center Blvd Winston-Salem NC 27157 USAEdward A. Levine, Wake Forest University Baptist Me...
Source: Journal of Gastrointestinal Surgery - December 17, 2008 Category: Surgery Tags: Journal of Gastrointestinal Surgery Source Type: journals

Treatment of appendiceal adenocarcinoma in the United States: penetration and outcomes of current guidelines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluates appendiceal cancer outcomes in the United States and treatment guideline compliance. Data for patients diagnosed with appendiceal adenocarcinoma in the Surveillance, Epidemiology, and End Results database (1988 to 2003) were analyzed. The 2511 patients with appendiceal adenocarcinoma had an average age of 59.3 years, average tumor size of 4.05 cm, and 5-year survival rate of 57 per cent. The 5-year survival rate by stage was statistically different (P < 0.001): Stage 0, 95.7 per cent; Stage I, 88 per cent; Stage II, 75.2 per cent; Stage III, 37.1 per cent; and Stage IV, 25.6 per cent. Appendectomy w...
Source: The American Surgeon - November 1, 2008 Category: Surgery Authors: Walters KC, Paton BL, Schmelzer TS, Gersin KS, Iannitti DA, Kercher KW, Heniford BT Tags: Am Surg Source Type: journals

Primary signet ring cell carcinoma of the appendix: A rare case report and our 18-year experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary adenocarcinoma of the appendix is a rare malignancy that constitutes < 0.5% of all gastrointestinal neoplasms. Moreover, primary signet ring cell carcinoma of the appendix is an exceedingly rare entity. We have encountered 15 cases of primary appendiceal cancer among 3389 patients who underwent appendectomy over the past 18 years. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastases and unresectable peritoneal dissemination occurring in a 67-year-old female patient. She underwent appendectomy and bilateral salpingo-oophorectomy with a la...
Source: World Journal of Gastroenterology : WJG - October 7, 2008 Category: Gastroenterology Authors: Ko YH, Jung CK, Oh SN, Kim TH, Won HS, Kang JH, Kim HJ, Kang WK, Oh ST, Hong YS Tags: World J Gastroenterol Source Type: journals

Consensus guidelines for the management of patients with digestive neuroendocrine tumours - well-differentiated tumour carcinoma of the appendixEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aims: This is the most up to date guideline for the management of patients with neuroendocrine tumours. This consensus document has been produced under the auspices of the European Neuroendocrine Tumour Society. Intended audience: All healthcare professionals involved in managing patients with digestive NETs. (Source: NHS Evidence - gastroenterology and liver diseases - Updates for Neuroendocrine Tumours)
Source: NHS Evidence - gastroenterology and liver diseases - Updates for Neuroendocrine Tumours - May 1, 2008 Category: Gastroenterology Source Type: organizations

Researchers Study New Drug And Indications For Heated Chemotherapy TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Studies have shown that surgery combined with Intraperitoneal Hyperthermic Chemotherapy (IPHC) can improve survival rates for select patients with peritoneal carcinoma (cancer of the lining of the abdominal cavity) that has spread from colorectal or appendix cancer. Researchers from Wake Forest University School of Medicine will present findings from two studies on the use of IPHC in treating peritoneal cancer that has spread from these two primary cancer sites at the annual meeting of the Society of Surgical Oncology in Chicago, March 13-16. John H. Stewart, IV, M.D., assistant professor of surgery, section of surgical on...
Source: Cancercompass News: Colorectal Cancer - April 5, 2008 Category: Cancer & Oncology Source Type: news

Studies Review New Drug And Indications For Heated ChemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Studies have shown that surgery combined with Intraperitoneal Hyperthermic Chemotherapy (IPHC) can improve survival rates for select patients with peritoneal carcinoma (cancer of the lining of the abdominal cavity) that has spread from colorectal or appendix cancer. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - March 15, 2008 Category: Cancer & Oncology Source Type: news

Diagnostic limitations of 10 mm thickness single-slice computed tomography for patients with suspected appendicitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion CT examination is useful for patients with suspected appendicitis, but radiologists should be aware of the limitation of thick-sliced single helical CT. They should also be aware of the possibility of other diseases, including coincident abdominal neoplasms and underlying cecal-appendiceal cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11604-007-0196-5Authors Motoki Kaidu, Sado General Hospital Department of Diagnostic Imaging and Internal Medicine 113-1 Chigusa Sado 952-1209 JapanManabu Oyamatu, Sado General Hospital Department of Surgery Sado JapanKenji Sato, Sa...
Source: Radiation Medicine - February 27, 2008 Category: Radiology Tags: Radiation Medicine Source Type: journals

[Treatment of peritoneal carcinomatosis with surgery and hyperthermic peroperative intraperitoneal chemotherapy (HIPEC): new aspects and validated indications]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is now an entire part of treatment of peritoneal dissemination of colorectal malignancy, and it's possible to hope prolonged survival. This treatment is more and more codified. Four indications are recognized by some tree national evaluation committees: the French ANAES, the British NICE and the Canadian CEPO: colorectal carcinoma, carcinoma of the appendix, pseudomyxoma peritonei and mesothelioma. Last big published series results show a decrease of morbidity and mortality and interest of using new drugs like oxaliplatine. Indications have to be more hom...
Source: Bulletin du Cancer - January 1, 2008 Category: Cancer & Oncology Authors: Eveno C, Dagois S, Guillot E, Gornet JM, Pocard M Tags: Bull Cancer Source Type: journals

Aggressive Surgical Management of Peritoneal Carcinomatosis With Low Mortality in a High-Volume Tertiary Cancer CenterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In a high-volume center with extensive experience treating peritoneal malignancies, perioperative mortality can be lowered to nearly zero, although morbidity remains high. CS-HIPEC procedures should be studied further in a controlled manner to help define their important role in the care of patients with PC. Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-007-9701-4Authors Niraj J. Gusani, University of Pittsburgh Medical Center Division of Surgical Oncology, Department of Surgery Pittsburgh Pennsylvania USASung W. Cho, University of Pittsburgh Medical Cent...
Source: Annals of Surgical Oncology - December 14, 2007 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Survival and Health Outcomes After Cytoreductive Surgery With Intraperitoneal Hyperthermic Chemotherapy for Disseminated Peritoneal Cancer of Appendiceal OriginEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Although complications can affect short-term recovery, survival in appendix cancer patients with peritoneal cancer is good and for some can be achieved without major decrements in QOL at 1 year. Depressive symptoms and some physical limitations remain in surviving patients. Content Type Journal ArticleCategory Healthcare Policy and OutcomesDOI 10.1245/s10434-007-9678-zAuthors Richard P. McQuellon, Wake Forest University School of Medicine Department of Internal Medicine, Section of Hematology and Oncology Medical Center Blvd Winston-Salem North Carolina 27157-1082 USAGregory B. Russell, Wa...
Source: Annals of Surgical Oncology - November 21, 2007 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Treatment of patients with appendiceal cancer and peritoneal dissemination.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 17850854 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - September 10, 2007 Category: Cancer & Oncology Authors: van Nagell JR, Desimone CP Tags: Gynecol Oncol Source Type: journals

Carcinoma of the appendix: Report of two casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content TypeJournal Article JournalDiseases of the Colon & RectumOnline ISSN 1530-0358Print ISSN 0012-3706 Journal VolumeVolume 17 Journal IssueVolume 17, Number 3 / May, 1974 (Source: Diseases of the Colon & Rectum)
Source: Diseases of the Colon & Rectum - March 24, 2007 Category: Gastroenterology Tags: Diseases of the Colon & Rectum Source Type: journals

Signet ring cell carcinoma of the appendix presenting with intestinal obstructionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report our patient who presented with intestinal obstruction due to a signet ring cell carcinoma of the appendix, (studies proved that it was not a primary colonic lesion invading the appendix) and review literature of this very uncommon lesion. (Source: Indian Journal of Surgery)
Source: Indian Journal of Surgery - February 17, 2007 Category: Surgery Authors: Arcot Rekha, Thanka J, Rajendiran S, Ravi A Source Type: journals

Perioperative intraperitoneal chemotherapy for peritoneal surface malignancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The treatment of peritoneal surface malignancy mainly focuses on diffuse malignant peritoneal mesothelioma, pseudomyxoma peritonei from appendiceal cancer, and peritoneal dissemination from gastrointestinal and ovarian cancers. Cancer progression causes peritoneal implants to be distributed throughout the abdominopelvic cavity. These nodules plus the ascitic fluid result in abdominal distension. As the disease progresses, these tumors cause intestinal obstruction leading to debilitating symptoms and a greatly impaired quality of life. In the past, the prognosis of patients with peritoneal surface malignancy was regarded di...
Source: Journal of Translational Medicine - April 10, 2006 Category: Research Authors: Tristan D Yan, Oswald A Stuart, Dal Yoo and Paul H Sugarbaker Source Type: journals