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882 records returned

Novel de novo Mutation in the KCNJ2 Gene in a Patient With Andersen-Tawil SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Andersen-Tawil syndrome is a rare autosomal-dominant disease characterized by episodic muscle weakness, cardiac arrhythmias, and dysmorphic features. Mutations in the KCNJ2 gene (which encodes an inward-rectifying potassium channel protein, Kir2.1) have been reported to be responsible for this disorder. Reported here is a novel de novo mutation in the KCNJ2 gene in a patient with Andersen-Tawil syndrome. This mutation predicts the substitution of alanine for glycine at position 146 (Gly146Ala, c.437G > C) of Kir2.1 and is located at the extracellular pore loop region that serves as a principal ion-selective filter. The pat...
Source: Pediatric Neurology - November 20, 2009 Category: Neurology Authors: June-Bum Kim, Ki-Wha Chung Tags: Case Reports Source Type: journals

Genotype–Phenotype Relationship in the Long QT Syndrome: Brimming With Knowledge but Thirsting for a Therapeutic Solution⁎Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since it was first reported 50 years ago, the long QT syndrome (LQTS) is now recognized as a genetic disease caused by mutations of ion channel genes encoding a cardiac channel essential for the control of ventricular repolarization (). The LQTS is not only the most common and extensively researched genetic cardiac arrhythmia (), it has also attracted premier scientists and scholars in single-cell electrophysiology and molecular genetics. In turn, they have produced seminal discoveries that shaped our understanding of the syndrome. The mutated genes in LQTS patients cause delayed repolarization and, in turn, prolong the QT...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Koonlawee Nademanee Tags: Editorial Comment Source Type: journals

Does This Patient With Palpitations Have a Cardiac Arrhythmia? [The Rational Clinical Examination]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions While the presence of a regular rapid-pounding sensation in the neck or visible neck pulsations associated with palpitations makes the diagnosis of atrioventricular nodal reentry tachycardia likely, the reviewed studies suggest that the clinical examination is not sufficiently accurate to exclude clinically significant arrhythmias in most patients. Thus, prolonged electrocardiographic monitoring with demonstration of symptom-rhythm correlation is required to make the diagnosis of a cardiac arrhythmia for most patients with recurrent palpitations. (Source: JAMA)
Source: JAMA - November 17, 2009 Category: Journals (General) Authors: Thavendiranathan, P., Bagai, A., Khoo, C., Dorian, P., Choudhry, N. K. Tags: Physical Examination, Cardiovascular System, Radiologic Imaging, Diagnosis, Echocardiography, Arrhythmias, Cardiac Diagnostic Tests The Rational Clinical Examination Source Type: journals

Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Cardiac overexpression of a Ca2+-channel β2a-subunit alone is sufficient to induce Ca2+-channel properties characteristic of chronic human heart failure. β2a-overexpression by itself did not induce cardiac hypertrophy or contractile dysfunction, but aggravated the development of arrhythmia and fibrosis in Cav1.2-transgenic mice. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Beetz, N., Hein, L., Meszaros, J., Gilsbach, R., Barreto, F., Meissner, M., Hoppe, U. C., Schwartz, A., Herzig, S., Matthes, J. Tags: ORIGINAL ARTICLES Source Type: journals

Ca(V)1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mutations of human Ca(V)1.2 channel gene were identified only recently. The gain-of-function mutations were found at two mutually exclusive exons in patients with Timothy syndrome (TS). These patients exhibit prolonged QT interval and lethal cardiac arrhythmias. In contrast, the loss-of-function mutations of Ca(V)1.2 channel in patients with Brugada syndrome produce short QT interval that could result in sudden cardiac death. TS patients also suffer from multi-organ dysfunction that includes neurological disorder such as autism and mental retardation reflecting the wide tissue distribution of Ca(V)1.2 channel. Mutation...
Source: Pflugers Archiv : European Journal of Physiology - November 15, 2009 Category: Physiology Authors: Liao P, Soong TW Tags: Pflugers Arch Source Type: journals

A Single Exposure to Particulate or Gaseous Air Pollution Increases the Risk of Aconitine-Induced Cardiac Arrhythmia in Hypertensive RatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, a single exposure to air pollution may increase the sensitivity of cardiac electrical conduction to disruption. Moreover, there seem to be host factors (e.g., cardiovascular disease) that increase vulnerability to triggered arrhythmias regardless of the pollutant or its concentration. (Source: Toxicological Sciences)
Source: Toxicological Sciences - November 13, 2009 Category: Toxicology Authors: Hazari, M. S., Haykal-Coates, N., Winsett, D. W., Costa, D. L., Farraj, A. K. Tags: SYSTEMS TOXICOLOGY Source Type: journals

New Center For Cardiac Safety And Innovation Launched By URMCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The University of Rochester Medical Center (URMC) has announced the creation of a new center that will assist researchers studying the electrical activity of the heart with the goal of improving drug safety, understanding cardiac arrhythmias, and developing new electrocardiograph technologies. The Center for Quantitative Electrocardiology and Cardiac Safety - funded by a $2. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 13, 2009 Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news

New Center For Cardiac Safety And Innovation Launched By URMCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The University of Rochester Medical Center (URMC) has announced the creation of a new center that will assist researchers studying the electrical activity of the heart with the goal of improving drug safety, understanding cardiac arrhythmias, and developing new electrocardiograph technologies. The Center for Quantitative Electrocardiology and Cardiac Safety - funded by a $2. (Source: Cardiovascular / Cardiology News From Medical News Today)
Source: Cardiovascular / Cardiology News From Medical News Today - November 13, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news

New research center to focus on cardiac safety and innovationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(University of Rochester Medical Center) The University of Rochester Medical Center has announced the creation of a new center that will assist researchers studying the electrical activity of the heart with the goal of improving drug safety, understanding cardiac arrhythmias, and developing new electrocardiograph technologies. The Center for Quantitative Electrocardiology and Cardiac Safety -- funded by a $2.3 million grant from NIH -- brings together an international network of academic researchers, pharmaceutical and medical device companies, and government regulators. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 11, 2009 Category: Global & Universal Source Type: news

The Death of John Paul Jones and Resurrection as 'Father of the US Navy'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
John Paul Jones, 'father of the US Navy', died under mysterious circumstances on July 18, 1792. Although his remains were resurrected and autopsied 113 years later, the cause of his death has yet to be explained fully. In this detailed review of his clinical history and autopsy findings, we conclude, as have others, that Jones died of kidney failure of undermined etiology. Although 'interstitial nephritis' was diagnosed by the prosectors who performed his autopsy, we believe glomerulopathy (possibly IgA nephropathy) was more likely responsible for his kidney failure and that his death was due to a cardiac arrhythmia or...
Source: American Journal of Nephrology - November 11, 2009 Category: Urology & Nephrology Authors: Weir MR, Bogle LL, Mackowiak PA Tags: Am J Nephrol Source Type: journals

Clinical outcomes in medical outliers admitted to hospital with heart failure.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Patients admitted to the Department of Internal Medicine with heart failure had a longer stay if they initially start in other departments' wards. Significant differences were not seen in this group of patients with respect to mortality, readmission, or intra-hospital morbidity. PMID: 19892305 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - November 8, 2009 Category: Internal Medicine Authors: Alameda C, Suárez C Tags: Eur J Intern Med Source Type: journals

Application of HRV-CD for estimation of life expectancy in various clinical disorders.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Diminished HRV-CD is associated with heart failure, coronary artery disease, cardiac arrhythmia, renal dysfunction, diabetes mellitus and low serum potassium. Among the latter, heart failure is most significantly associated with decreased HRV-CD. Decreased HRV-CD values, especially in diabetics, are also associated with lower survival. PMID: 19892308 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - November 8, 2009 Category: Internal Medicine Authors: Almoznino-Sarafian D, Sarafian G, Zyssman I, Shteinshnaider M, Tzur I, Kaplan BZ, Berman S, Cohen N, Gorelik O Tags: Eur J Intern Med Source Type: journals

Predictive value of electrical restitution in hypokalemia-induced ventricular arrhythmogenicity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study highlights the superiority of ERP restitution at predicting increased arrhythmogenicity in hypokalemic myocardium. The lack of predictive value of APD90 restitution is presumably related to different mode of changes in ventricular repolarization and refractoriness in hypokalemic setting, whereby APD90 prolongation may be associated with shortened ERP. Key words: hypokalemia, cardiac arrhythmia, electrical restitution, ventricular refractoriness. PMID: 19897712 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - November 6, 2009 Category: Physiology Authors: Osadchii OE, Larsen AP, Olesen SP Tags: Am J Physiol Heart Circ Physiol Source Type: journals

Acetaminophen combinations protect against iron-induced cardiac damage in gerbils.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study tested if acetaminophen, N-methyl-D-glucamine dithiocarbamate (NMGDTC), deferoxamine, and combinations of these agents reduce excess iron content, prevent iron-induced pathology, reduce cardiac arrhythmias, and reduce mortality in iron-overloaded gerbils. Eight groups of 16 gerbils received iron dextran injections (ferric hydroxide dextran complex, 120 mg/kg, ip) or saline solution (controls) twice/wk for 8 wk. The 8 groups were treated every Monday, Wednesday, and Friday with one of the following: saline control, acetaminophen, 150 mg/kg, ip), acetaminophen (150 mg/kg, po), deferoxamine, 83 mg/kg, ip), NMGDTC (...
Source: Annals of Clinical and Laboratory Science - November 3, 2009 Category: Laboratory Medicine Authors: Walker EM, Morrison RG, Dornon L, Laurino JP, Walker SM, Studeny M, Wehner PS, Rice KM, Wu M, Blough ER Tags: Ann Clin Lab Sci Source Type: journals

Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atrial fibrillation is the most common clinical cardiac arrhythmia. It is often initiated by ectopic beats arising from the pulmonary veins and atrium, but the source and mechanism of these beats remains unclear. The melanin synthesis enzyme dopachrome tautomerase (DCT) is involved in intracellular calcium and reactive species regulation in melanocytes. Given that dysregulation of intracellular calcium and reactive species has been described in patients with atrial fibrillation, we investigated the role of DCT in this process. Here, we characterize a unique DCT-expressing cell population within murine and human hearts that...
Source: Journal of Clinical Investigation - November 3, 2009 Category: Biomedical Science Authors: Mark D. Levin, Min Min Lu, Nataliya B. Petrenko, Brian J. Hawkins, Tara H. Gupta, Deborah Lang, Peter T. Buckley, Jeanine Jochems, Fang Liu, Christopher F. Spurney, Li J. Yuan, Jason T. Jacobson, Christopher B. Brown, Li Huang, Friedrich Beermann, Kenneth Source Type: journals

Reduction in Cardiac Kir3.4 Channel Expression Causes Congenital Long QT Syndrome: A Functional Role of Girk Currents in Ventricular RepolarizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ventricular repolarization is promoted by delayed rectifier potassium currents. Mutations in the genes underlying these currents, primarily IKr, IKs, and IK1, have been found to cause congenital long QT syndrome (LQTS), which is an inherited disorder leading to sudden cardiac death from fatal cardiac arrhythmias. Kir3.1/3.4 channels have been ascribed a prominent role in atrial and nodal parasympathetic regulation, where acetylcholine-mediated muscarinic stimulation leads to activation of this channel complex, thereby generating G-protein-coupled inward rectifier potassium channel current (IK,ACh). However, a functional ro...
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Bo Liang, Yanzong Yang, Yiqing Yang, Jinqiu Liu, Morten Grunnet, Søren-Peter Olesen, Yi-Han Chen, Thomas Jespersen Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals

Epicardium-Derived Cells as Progenitors of Cardiac Fibroblasts: A Possible Role in Arrhythmogenic Right Ventricular Cardiomyopathy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC) is an inherited disease characterized by replacement of healthy myocardium with fibrous and fatty tissue, cardiac arrhythmias, and sudden death. ARVC has been associated with mutations in desmosomal proteins, most prominently in the gene coding for plakophilin-2 (PKP2). How disruption of desmosomal proteins in cardiac myocytes leads to the disproportionate extent of fibrosis, and fat accumulation, observed in ARVC-afflicted hearts is unclear. Here, we propose that fibrofatty infiltration has its origins (at least in part) in nonmyocyte cardiac cells. Our atte...
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Stephanie Matthes, Steven Taffet, Mario Delmar Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals

Coupling of Isolated Adult Rabbit Ventricular Myocytes to Fibroblasts Under Stress Induces AfterdepolarizationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ventricular fibrillation (VF) is the most lethal cardiac arrhythmia, yet the underlying mechanisms are poorly understood. VF occurs most commonly in the presence of markedly increased tissue fibrosis, as seen in aging or heart disease. We hypothesize that electrotonic coupling of ventricular myocytes to fibroblasts under stress can augment stress effects to impair myocyte repolarization reserve and promote the emergence of known VF triggers such as early afterdepolarizations (EADs) and triggered activity. (Source: Heart Rhythm)
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Thao P. Nguyen, James N. Weiss Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals

Homocysteine and P wave dispersion in patients with heart transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HHcy seems associated with an alteration in the electrical atrial conduction, possibly contributing, at least in part, to the increased risk of cardiac arrhythmias in the denervated hearts of OHT patients. (Source: Clinical Transplantation)
Source: Clinical Transplantation - October 30, 2009 Category: Transplant Surgery Authors: Maurizio Acampa, Pietro Enea Lazzerini, Francesca Guideri, Serena Rechichi, Pier Leopoldo Capecchi, Massimo Maccherini, Franco Laghi-Pasini Source Type: journals

Sleep apnoea induces cardiac electrical instability assessed by T-wave alternans in patients with congestive heart failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In CHF patients, sleep apnoea induces cardiac electrical instability manifested as TWA, reflecting increased risk of nocturnal SCD. Moreover, some CHF patients with sleep apnoea exhibit nighttime predominant TWA. Therefore, TWA should also be evaluated during the night. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - October 29, 2009 Category: Cardiology Authors: Takasugi, N., Nishigaki, K., Kubota, T., Tsuchiya, K., Natsuyama, K., Takasugi, M., Nawa, T., Ojio, S., Aoyama, T., Kawasaki, M., Takemura, G., Minatoguchi, S. Tags: SLEEP APNOEA Source Type: journals

Pathophysiological insights into atrial fibrillation following cardiac surgery: implications for current pharmaceutical design.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Atrial fibrillation (AF) following cardiac surgery is a common complication, which increases incidence of other complications, hospital and healthcare costs. The reported rate of the occurrence of postoperative AF varies with different studies, depending on population profile, type of surgery, arrhythmia definition and detection methods, design of study. Nonetheless, the precise mechanisms of AF related to cardiac surgery are poorly understood. A diverse variety of reasons have been proposed for the pathogenesis of this common cardiac arrhythmia. The aim of this review article is to provide an overview of pathophysiolo...
Source: Current Pharmaceutical Design - October 29, 2009 Category: Drugs & Pharmacology Authors: Kaireviciute D, Aidietis A, Lip GY Tags: Curr Pharm Des Source Type: journals

Sleep apnea-CV link bolsteredEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The occurrence of breathing disturbances during sleep can directly trigger cardiac arrhythmias in some individuals, study findings published in the Journal of the American College of Cardiology suggest. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - October 29, 2009 Category: Cardiology Source Type: news

Fundamental frequency and regularity of cardiac electrograms with Fourier organization analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dominant frequency analysis (DFA) and spectral organization analysis on cardiac electrograms (EGM) are receiving much attention to establish clinical targets for cardiac arrhythmia ablation. However, previous spectral descriptions of the EGM have been constrained to the 0- to 30-Hz band; in doing so, they often discard relevant information, as the harmonic structure, the spectral envelope, or the presence of several organized mechanisms. (Source: Journal of Electrocardiology)
Source: Journal of Electrocardiology - October 24, 2009 Category: Cardiology Authors: Óscar Barquero-Pérez, José Luis Rojo-Álvarez, Rebeca Goya-Esteban, Felipe Alonso-Atienza, J.J. Sánchez-Muñoz, Jesús Requena-Carrión, Arcadi García-Alberola Tags: Poster Session 1 and 2 Source Type: journals

Mitochondrial Involvement in Cardiac Apoptosis During Ischemia and Reperfusion: Can We Close the Box?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Myocardial ischemia is the main cause of death in the Western societies. Therapeutic strategies aimed to protect the ischemic myocardium have been extensively studied. Reperfusion is the definitive treatment for acute coronary syndromes, especially acute myocardial infarction; however, reperfusion has the potential to exacerbate tissue injury, a process termed reperfusion injury. Ischemia/reperfusion (I/R) injury may lead to cardiac arrhythmias and contractile dysfunction that involve apoptosis and necrosis in the heart. The present review describes the mitochondrial role on cardiomyocyte death and some potential pharm...
Source: Cardiovascular Toxicology - October 24, 2009 Category: Cardiology Authors: Machado NG, Alves MG, Carvalho RA, Oliveira PJ Tags: Cardiovasc Toxicol Source Type: journals

Rescue of a Trafficking Defective Human Pacemaker Channel via a Novel Mechanism: ROLES OF Src, Fyn, AND Yes TYROSINE KINASES [Membrane Transport, Structure, Function, and Biogenesis]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we demonstrate a novel mechanism using three endogenous Src kinases to rescue a trafficking defective HCN4 mutant channel (D553N) by enhancing the tyrosine phosphorylation of the mutant channel protein. (Source: Journal of Biological Chemistry)
Source: Journal of Biological Chemistry - October 23, 2009 Category: Chemistry Authors: Lin, Y.-C., Huang, J., Kan, H., Frisbee, J. C., Yu, H.-G. Tags: Membrane Transport, Structure, Function, and Biogenesis Source Type: journals

Occupational obstructive airway diseases caused by the natural gas odorant tetrahydrothiophene - two case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tetrahydrothiophene (THT) is frequently used to odorize natural (city) gas. Only sparse data on adverse health effects of THT on humans are available.We performed a literature search and clinical investigations including case history and cardiopulmonary diagnostic tests in two symptomatic THT-exposed outpatients.The two THT-exposed city workers developed transient neurologic symptoms such as nausea, vomiting, headaches, as well as skin and mucosa irritation, chronic rhinitis, chronic obstructive pulmonary disease, arterial hypertension, and cardiac arrhythmia. The neurological symptoms and respiratory disorders were found ...
Source: American Journal of Industrial Medicine - October 21, 2009 Category: Occupational Health Authors: X. Baur, C. Bittner Source Type: journals

Cardiac Arrhythmias in Multiple Organ Dysfunction Syndrome: A Mechanistic ApproachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiology 2010;115:37-38 (DOI:10.1159/000249281) (Source: Karger Publishers)
Source: Karger Publishers - October 19, 2009 Category: Cancer & Oncology Source Type: journals

Thyroid hormones and cardiac arrhythmias.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thyroid hormone plays an important role in cardiac electrophysiology and Ca(2+) handling through both genomic and nongenomic mechanisms of action, while both actions can interfere. Chronic changes in the amount of circulating thyroid hormone due to thyroid dysfunction or systemic disease result in structural, electrophysiological and Ca(2+) handling remodeling, while acute changes may affect basal activity of cardiac cells membrane systems. Consequently, long-term or rapid modulation of sarcolemmal ion channels, Ca(2+) cycling proteins and intercellular communicating channels by thyroid hormone may affect heart functio...
Source: Vascular Pharmacology - October 19, 2009 Category: Drugs & Pharmacology Authors: Tribulova N, Knezl V, Shainberg A, Seki S, Soukup T Tags: Vascul Pharmacol Source Type: journals

Coagulation alterations in treating arrhythmias with radiofrequency ablation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION. Despite diminished platelet aggregation and increased D-dimer level right after radiofrequency ablation, a risk of thrombosis increased in the next few days after radiofrequency ablation. PMID: 19834307 [PubMed - as supplied by publisher] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 17, 2009 Category: Universities & Medical Training Authors: Kozlovaitė V, Grybauskas P, Cimbolaitytė J, Mongirdienė A, Sileikis V, Zabiela V, Kažanienė J, Ptašekas J Tags: Medicina (Kaunas) Source Type: journals

Biosense Webster Receives FDA Clearance For The CARTO(R) 3 SystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biosense Webster, Inc., a worldwide leader in the diagnosis and treatment of cardiac arrhythmias, announced today that the U.S. Food and Drug Administration (FDA) has cleared for marketing the CARTO® 3 System, the most advanced three-dimensional imaging technology for use by electrophysiologists in treating cardiac arrhythmias, commonly referred to as irregular heart rhythms. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 16, 2009 Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news

Ankyrin protein networks in membrane formation and stabilization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In eukaryotic cells, ankyrins serve as adaptor proteins that link membrane proteins to the underlying cytoskeleton. These adaptor proteins form protein complexes consisting of integral membrane proteins, signaling molecules, and cytoskeletal components. With their modular architecture and ability to interact with many proteins, ankyrins organize and stabilize these protein networks, thereby establishing the infrastructure of membrane domains with specialized functions. To this end, ankyrin collaborates with a number of proteins including cytoskeletal proteins, cell adhesion molecules, and large structural prot...
Source: J Cell Mol Med - October 15, 2009 Category: Molecular Biology Authors: Cunha SR, Mohler PJ Tags: J Cell Mol Med Source Type: journals

Biosense Webster Receives FDA Clearance for the CARTO(R) 3 SystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
State-of-the-Art Navigational Mapping System Offers Unique Combination of Accuracy, Speed and Efficiency DIAMOND BAR, Calif.--(HSMN NewsFeed)--Biosense Webster, Inc., a worldwide leader in the diagnosis and treatment of cardiac arrhythmias, announced to... Devices, Cardiology, FDABiosense Webster, CARTO , electrophysiology, atrial fibrillation (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - October 15, 2009 Category: Pharmaceuticals Source Type: news

Biosense Webster Receives FDA Clearance for the CARTO® 3 SystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
State-of-the-Art Navigational Mapping System Offers Unique Combination of Accuracy, Speed and Efficiency DIAMOND BAR, Calif.--(HSMN NewsFeed)--Biosense Webster, Inc., a worldwide leader in the diagnosis and treatment of cardiac arrhythmias, announced to... Devices, CardiologyBiosense Webster, CARTO 3 System (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - October 15, 2009 Category: Pharmaceuticals Source Type: news

FDA clears Biosense Webster’s EP imaging technologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The FDA has cleared for marketing Biosense Webster’s Carto 3 system, its 3D imaging technology, for use by electrophysiologists (EP) in treating cardiac arrhythmias. (Source: Cardiovascular Business News)
Source: Cardiovascular Business News - October 15, 2009 Category: Cardiology Tags: Latest News Source Type: news

FDA clears Biosense Webster’s EP imaging technologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The FDA has cleared for marketing Biosense Webster’s Carto 3 system, its 3D imaging technology, for use by electrophysiologists (EP) in treating cardiac arrhythmias. (Source: Health Imaging News)
Source: Health Imaging News - October 15, 2009 Category: Radiology Tags: Latest News Source Type: news

A fatal case of myocardial damage due to misuse of the “designer drug” MDMAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A 39-year-old woman collapsed after oral intake of 3,4-methylenedioxymethyl-amphetamine (MDMA, “ecstasy”). After ingestion of the drug, she had felt persistent discomfort in her anterior chest area, and lost consciousness for a few minutes on the following morning. She was transported to a hospital and died seven days after collapse. A serum sample obtained on admission revealed an MDMA concentration of 1.2mg/L, but no evidence of any other drug including amphetamine, methamphetamine, or other ring-substituted amphetamines. Microscopic examination at autopsy revealed striking changes in the heart, including s...
Source: Legal Medicine - October 15, 2009 Category: Forensic Medicine Authors: Rie Sano, Toshikazu Hasuike, Minoru Nakano, Yoshihiko Kominato, Hideaki Itoh Tags: Case Reports Source Type: journals

Association Between Symptoms of Depression and Anxiety With Heart Rate Variability in Patients With Implantable Cardioverter DefibrillatorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Depression and anxiety in defibrillator patients are associated with autonomic nervous system dysfunction indices of reduced parasympathetic control. Autonomic nervous system dysfunction may partially explain the association between depression and anxiety with life-threatening cardiac outcomes in vulnerable patients. (Source: Psychosomatic Medicine)
Source: Psychosomatic Medicine - October 14, 2009 Category: Psychiatry & Psychology Authors: Francis, J. L., Weinstein, A. A., Krantz, D. S., Haigney, M. C., Stein, P. K., Stone, P. H., Gottdiener, J. S., Kop, W. J. Tags: Anxiety, Parasympathetic Nervous System, Depression, Sympathetic Nervous System ORIGINAL ARTICLES Source Type: journals

Autonomy of Autonomic Dysfunction in Major DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients suffering from MDD show profound autonomic dysfunction, which is exacerbated by SNRI and to a lesser degree by SSRI treatment. This information could prove important when selecting antidepressant medication for patients at risk for cardiac arrhythmias. (Source: Psychosomatic Medicine)
Source: Psychosomatic Medicine - October 14, 2009 Category: Psychiatry & Psychology Authors: Koschke, M., Boettger, M. K., Schulz, S., Berger, S., Terhaar, J., Voss, A., Yeragani, V. K., Bar, K.-J. Tags: Parasympathetic Nervous System, Depression, Sympathetic Nervous System ORIGINAL ARTICLES Source Type: journals

EU approves ATS Medical’s cryoablation probe for cardiac arrythmiasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ATS Medical, manufacturer of cardiac surgery products and services, has received the CE Mark for the ATS CryoMaze 10-S surgical cryoablation probe for the treatment of cardiac arrhythmias. (Source: Cardiovascular Business News)
Source: Cardiovascular Business News - October 14, 2009 Category: Cardiology Tags: Latest News Source Type: news

ATS Medical receives European approval for new deviceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ATS Medical Inc. said Tuesday it has received European regulatory approval for its ATS CryoMaze 10-S Surgical Cryoablation Probe for the treatment of cardiac arrhythmias. (Source: bizjournals.com Health Care:Health Insurance headlines)
Source: bizjournals.com Health Care:Health Insurance headlines - October 13, 2009 Category: American Health Source Type: journals

ATS Medical receives European approval for new deviceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ATS Medical Inc. said Tuesday it has received European regulatory approval for its ATS CryoMaze 10-S Surgical Cryoablation Probe for the treatment of cardiac arrhythmias. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - October 13, 2009 Category: Biotechnology Source Type: journals

Impact of Occluder Device Type on Success of Percutaneous Closure of Atrial Septal Defects–A Medium-Term Follow-up StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Percutaneous closure of patent foramen ovale or atrial septal defect is a safe procedure with little incidence of peri- and postprocedural complications. There is a significant difference between the Amplatzer[trade], Cardiastar[trade], and Starflex[trade] occluders in regard to complete closure of the defects and annual recurrence of thromboembolic events. (J Interven Cardiol 2009;**:1[ndash]8) (Source: Journal of Interventional Cardiology)
Source: Journal of Interventional Cardiology - October 11, 2009 Category: Cardiology Authors: MICHAEL BECKER, DOROTHEE FRINGS, JÖRG SCHRÖDER, CHRISTINA OCKLENBURG, EBERHARD MÜHLER, RAINER HOFFMANN, ANDREAS FRANKE, WOLFGANG LEPPER Source Type: journals

Increased QT variability in patients with anorexia nervosa - An indicator for increased cardiac mortality?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined the relative importance of repolarization abnormalities and vagal modulation of heart rate. In particular, we hypothesized that patients with anorexia nervosa show increased QT interval variability, particularly since this measure has been shown to correlate with serious cardiac arrhythmias.We assessed linear and nonlinear heart rate variability (HRV) parameters as well as measures of QT variability in 20 female patients with anorexia nervosa and 20 controls. In patients, parameters were correlated with serum electrolytes.QT variability was significantly increased in the patient group and correla...
Source: International Journal of Eating Disorders - October 8, 2009 Category: Eating Disorders and Weight Management Authors: Mandy Koschke, Michael K. Boettger, Claudia Macholdt, Steffen Schulz, Vikram K. Yeragani, Andreas Voss, Karl-Jürgen Bär Source Type: journals

Status Epilepticus Induces Cardiac Myofilament Damage and Increased Susceptibility to Arrhythmias in Rat.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Status epilepticus (SE) is a seizure or series of seizures that persist for >30 min, and often results in mortality. Death rarely occurs during or immediately following seizure activity, but usually within 30 days. Although ventricular arrhythmias have been implicated in SE-related mortality, the effects of this prolonged seizure activity on the cardiac function, and susceptibility to arrhythmias have not been directly investigated. We evaluated myocardial damage, alterations in cardiac electrical activity, and susceptibility to experimentally-induced arrhythmias produced by SE in rats. SE resulted in seizure-relate...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 8, 2009 Category: Physiology Authors: Metcalf CS, Poelzing S, Little JG, Bealer SL Tags: Am J Physiol Heart Circ Physiol Source Type: journals

Brain death diagnosis and apnea test safetyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Machado Calixto, Perez Jesus, Scherle Claudio, Areu Alejandro, Pando AlejandroAnnals of Indian Academy of Neurology 2009 12(3):197-200The apnea test is a mandatory examination for determining brain death (BD), because it provides an essential sign of definitive loss of brainstem function. However, several authors have expressed their concern about the safety of this procedure as there are potential complications such as severe hypotension, pneumothorax, excessive hypercarbia, hypoxia, acidosis, and cardiac arrhythmia or asystole. These complications may constrain the examiner to abort the test, thereby compromising BD diag...
Source: Annals of Indian Academy of Neurology - October 8, 2009 Category: Neurology Authors: Machado Calixto, Perez Jesus, Scherle Claudio, Areu Alejandro, Pando Alejandro Source Type: journals

Antineoplastic Chemotherapy Induced QTc Prolongation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anticancer drugs are sometimes associated with QT prolongation. Classical, new and candidate agents to treat cancer may affect ventricular repolarization through a set of different mechanisms. Interference on human ether-a-go-go-related gene potassium ion channels (HERG K+) seems to be a common mechanism for many of these drugs. Anthracycline chemotherapy is associated with electrocardiographic alterations including prolongation of QT interval, development of ventricular late potentials and various arrhythmias. The effects of the interaction of anthracyclines with the monoclonal antibody against HER2/neu (Erb-2) trastu...
Source: Current Drug Safety - October 6, 2009 Category: Drugs & Pharmacology Authors: Bagnes C, Panchuk PN, Recondo G Tags: Curr Drug Saf Source Type: journals

Hansen showcases new catheterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hansen Medical is showcasing its new Lynx Robotic Ablation Catheter this week at Venice Arrhythmias 2009, an International Workshop on Cardiac Arrhythmias in Venice, Italy. (Source: Diagnostic Imaging)
Source: Diagnostic Imaging - October 5, 2009 Category: Radiology Source Type: info

Evaluation of the Effects of PM101, a Cyclodextrin-Based Formulation of Intravenous Amiodarone, on Blood Pressure in Healthy HumansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the results of this study demonstrate that PM101 is devoid of hypotension in healthy human subjects. The absence of a hypotensive effect of AIV in this population suggests that further evaluation is needed in a patient population with cardiac disease. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - October 5, 2009 Category: Cardiology Authors: Daniel J. Cushing, Michael P. Adams, Warren D. Cooper, Bing Zhang, Raymond J. Lipicky, Peter R. Kowey Tags: Cardiovascular Pharmacology Source Type: journals

Fatal poisoning by accidental inhalation of aluminium phosphide. - Pérez Navero JL, Ibarra de la Rosa I, Frías Pérez MA, Arroyo Marín MJ, Pérez Jorge P.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cases of two 6 and 9-year-old sisters with lethal poisoning by inhalation of aluminium phosphide, after its inadequate use in a rural environment, are described. The clinical symptoms consisted of sudden vomiting, cardiac arrhythmias, shock, dyspnea, p... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - October 4, 2009 Category: Global & Universal Tags: Poisoning Source Type: info