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Echocardiography in cardiac resynchronization therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A terapia de ressincronização cardíaca (TRC) tem sido uma opção efetiva nos pacientes com insuficiência cardíaca avançada. No entanto 20% a 30% dos pacientes não apresentam benefícios nessa terapêutica. Critérios clínicos, eletrocardiográficos e ecocardiográficos têm sido estudados na tentativa de selecionar os pacientes que serão beneficiados com a ressincronização cardíaca, mas o ecocardiograma tem papel importante tanto na seleção quanto na avaliação e otimização dessa terapêutica. O objetivo desta revisão é descrever os principais parâmetros ecocardiográficos utilizados na avaliação da ...
Source: Arquivos Brasileiros de Cardiologia - November 20, 2009 Category: Cardiology Source Type: journals

Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes from 2004 to 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Implantation rates of devices for HF, in particular ICD and CRT-D, have increased significantly between 2004 and 2008 in Europe, but there remain major differences between countries. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: van Veldhuisen, D. J., Maass, A. H., Priori, S. G., Stolt, P., van Gelder, I. C., Dickstein, K., Swedberg, K. Tags: EPIDEMIOLOGY Source Type: journals

Right atrial size and deformation in patients with dilated cardiomyopathy undergoing cardiac resynchronization therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Right atrial area index was increased and RA myocardial deformation was impaired in patients with DCM who were non-responders to CRT. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: D'Andrea, A., Scarafile, R., Riegler, L., Salerno, G., Gravino, R., Cocchia, R., Castaldo, F., Allocca, F., Limongelli, G., Di Salvo, G., Cuomo, S., Pacileo, G., Caso, P., Russo, M. G., Calabro, R. Tags: ECHOCARDIOGRAPHY Source Type: journals

Clinical trials update from the European Society of Cardiology Meeting 2009: AAA, RELY, PROTECT, ACTIVE-I, European CRT survey, German pre-SCD II registry, and MADIT-CRTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides information and a commentary on trials relevant to the pathophysiology, prevention, and treatment of heart failure presented at the annual meeting of the European Society of Cardiology held in Barcelona in 2009. The AAA study does not support the routine use of aspirin for the prevention of vascular events in patients with asymptomatic atherosclerosis. RELY suggests that dabigatran may be more effective than warfarin for the prevention of stroke in patients with atrial fibrillation. Rolofylline was not superior to placebo in improving outcomes in patients with acute heart failure enrolled in the PROTE...
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Cleland, J. G.F., Coletta, A. P., Yassin, A., Buga, L., Torabi, A., Clark, A. L. Tags: MEETING REPORT Source Type: journals

Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Pre-implant GDF-15 is a strong predictor of mortality and morbidity after CRT, independent of NT pro-BNP. The predictive value of these analytes is enhanced by combined measurement. (Source: European Heart Journal)
Source: European Heart Journal - November 14, 2009 Category: Cardiology Authors: Foley, P. W.X., Stegemann, B., Ng, K., Ramachandran, S., Proudler, A., Frenneaux, M. P., Ng, L. L., Leyva, F. Tags: Heart failure/cardiomyopathy Source Type: journals

A simplified biventricular defibrillator with fixed long detection intervals reduces implantable cardioverter defibrillator (ICD) interventions and heart failure hospitalizations in patients with non-ischaemic cardiomyopathy implanted for primary prevention: the RELEVANT [Role of long dEtection window programming in patients with LEft VentriculAr dysfunction, Non-ischemic eTiology in primary prevention treated with a biventricular ICD] studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion A simplified CRT-D device with fixed long detection reduced overall ICD therapy burden and HF hospitalizations without entailing any additional adverse events in primary prevention non-ischaemic HF patients. (Source: European Heart Journal)
Source: European Heart Journal - November 14, 2009 Category: Cardiology Authors: Gasparini, M., Menozzi, C., Proclemer, A., Landolina, M., Iacopino, S., Carboni, A., Lombardo, E., Regoli, F., Biffi, M., Burrone, V., Denaro, A., Boriani, G. Tags: Arrhythmia/electrophysiology Source Type: journals

Cvn: madit-crtEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT) (Source: Cardiosource)
Source: Cardiosource - November 12, 2009 Category: Cardiology Source Type: organizations

CRT-induced LV reverse remodeling described in mild HFEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiac resynchronization therapy resulted in major structural and functional left ventricular reverse remodeling at 1 year in patients with New York Heart Association class I or II heart failure, show findings from the REVERSE trial. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - November 11, 2009 Category: Cardiology Source Type: news

CRT-induced LV reverse remodeling described in mild HFEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiac resynchronization therapy resulted in major structural and functional left ventricular reverse remodeling at 1 year in patients with New York Heart Association class I or II heart failure, show findings from the REVERSE trial. (Source: MedWire News - Heart Failure)
Source: MedWire News - Heart Failure - November 11, 2009 Category: Cardiology Source Type: news

Medtronic Inc. Cardiac Rhythm Disease Managment - Medtronic Concerto - Class 2 RecallEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medtronic Concerto, C154DWK, Dual chamber implantable cardioverter defibrillator with cardiac resynchronization therapy, atrial and ventricular therapies. Medtronic, Inc., Minneapolis, MN 55432 USA. (Source: Medical Device Recalls since July 07, 2006)
Source: Medical Device Recalls since July 07, 2006 - November 10, 2009 Category: Medical Equipment Source Type: organizations

Medtronic Inc. Cardiac Rhythm Disease Managment - Medtronic Concerto - Class 2 RecallEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This device is not approved in the United States. Medtronic Concerto, C174AWK. Dual Chamber implantable cardioverter defibrillator with cardiac resynchronization therapy, atrial and ventricular therapies. Medtronic, Inc., Minneapolis, MN 55432 USA. (Source: Medical Device Recalls since July 07, 2006)
Source: Medical Device Recalls since July 07, 2006 - November 10, 2009 Category: Medical Equipment Source Type: organizations

Impact of Tricuspid Regurgitation and Prior Coronary Bypass Surgery on the Geometry of the Coronary Sinus: A Rotational Coronary Angiography StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to examine the impact of the underlying cardiac pathology on the variability of the CS anatomy, using rotational coronary venous angiography (RCVA). Methods and Results: Seventy-nine patients undergoing RCVA for cardiac resynchronization therapy (CRT) were evaluated: age 63 ± 15 years, 43% with prior coronary artery bypass grafting (CABG). Aspects of the CS anatomy which could impact cannulation were examined: the CS ostial angle, the posterior displacement of the CS away from the atrioventricular groove, a measure of CS curvature, and the presence of stenoses and aneurysmal dilatations. Th...
Source: Journal of Cardiovascular Electrophysiology - November 10, 2009 Category: Cardiology Authors: DAN BLENDEA, E. KEVIN HEIST, SAUMYA DAS, STEPHAN DANIK, CONOR BARRETT, THEOFANIE MELA, JEREMY N. RUSKIN, JAGMEET P. SINGH Source Type: journals

CRT benefit in mild HF shown by REVERSE 2-year dataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiac resynchronization therapy is associated with improved clinical outcomes and reduced left ventricular dimensions in heart failure patients in New York Heart Association functional classes I or II, show 2-year results for the European cohort in REVERSE. (Source: MedWire News - Heart Failure)
Source: MedWire News - Heart Failure - November 9, 2009 Category: Cardiology Source Type: news

Optimization of the Interventricular Delay in Cardiac Resynchronization Therapy Using the QRS WidthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Optimization of the interventricular pacing delay (VV) in cardiac resynchronization therapy is time-consuming and not routinely performed. The aim of the present study was to compare the acute hemodynamic response obtained by different VV programming methods. Several methods for optimizing the VV using electrocardiographic or echocardiographic measurements were performed. The effect of programming an empirical prefixed VV of 0 ms was also evaluated. Invasive first derivative of left ventricular (LV) pressure over time (dP/dt max) was measured at several VV values, and the hemodynamic response that could be obtained by each...
Source: The American Journal of Cardiology - November 5, 2009 Category: Cardiology Authors: David Tamborero, Lluís Mont, Marta Sitges, Etelvino Silva, Antonio Berruezo, Barbara Vidal, Victoria Delgado, Jose M. Tolosana, Miguel Godoy, Angeles Castel, Josep Brugada Tags: Heart Failure Source Type: journals

CRT benefit in mild HF shown by REVERSE 2-year dataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiac resynchronization therapy is associated with improved clinical outcomes and reduced left ventricular dimensions in heart failure patients in New York Heart Association functional classes I or II, show 2-year results for the European cohort in REVERSE. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - November 4, 2009 Category: Cardiology Source Type: news

Cardiac resynchronization therapy: a review of CRT-D versus CRT-PEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Future Cardiology , November 2009, Vol. 5, No. 6, Pages 567-572. (Source: Future Cardiology)
Source: Future Cardiology - November 3, 2009 Category: Cardiology Tags: article Source Type: journals

MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy): cardiac resynchronization therapy towards early management of heart failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Heart Journal)
Source: European Heart Journal - November 1, 2009 Category: Cardiology Authors: Breithardt, G. Tags: ESC BARCELONA COMMENTARIES Source Type: journals

Cardiac Resynchronization Therapy in Patients with Recurrent Heart Failure and Intermittent LBBBEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Indications for cardiac resynchronization therapy (CRT) include prolonged QRS duration (typically LBBB), advanced heart failure (HF, NYHA III/IV), and severe left ventricular (LV) dysfunction. The role of CRT in patients with intermittent LBBB associated with acute HF is unknown. (Source: Heart Rhythm)
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Rehan Mahmud, Alawi A. Alsheikh-Ali, Salem Alkaabi, Arshad Rasheed Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals

Reduction in the Risk of Heart Failure with Preventive Cardiac Resynchronization Therapy: MADIT-CRT TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: The randomized Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) was designed to determine if prophylactic cardiac resynchronization therapy with defibrillator (CRT-D) would reduce the primary end point (all cause mortality or heart failure events [iv diuretic Rx or hospitalization Rx for HF], whichever occurred first, when compared to patients receiving only an implanted cardiac defibrillator (ICD-only). The study population involved patients with ischemic (NYHA I & II) and non-ischemic (NYHA II) cardiomyopathy with ejection fraction ≤0.30 and QRS ≥...
Source: Journal of Cardiac Failure - October 31, 2009 Category: Cardiology Authors: A.J. Moss, D.S. Cannom, H. Klein, W.J. Hall, M.W. Brown, J.P. Daubert, N.A.M. Estes, E. Foster, H. Greenberg, S.L. Higgins, M.A. Pfeffer, S.D. Solomon, D. Wilber, W. Zarebathe, MADIT-CRT Investigators Tags: Late-Breaking Clinical Trial Presentations Source Type: journals

Cardiac resynchronization therapy upgrade in a patient with dextrocardia and situs inversusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of upgrade of an implantable cardioverter defibrillator to a resynchronization device, in a patient with dextrocardia and situs inversus. The procedure was successfully performed without complication, using a conventional approach and standard equipment. (Source: Europace)
Source: Europace - October 30, 2009 Category: Cardiology Authors: Scott, P. A., Roberts, P. R. Tags: CASE REPORTS Source Type: journals

Characterization of the suitability of coronary venous anatomy for targeting left ventricular lead placement in patients undergoing cardiac resynchronization therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Underlying aetiology does not affect the quantity and distribution of coronary veins available for LV lead placement. The limitations of venous anatomy restrict LV lead placement to a single vein with little scope for site selection in almost half of all the patients. Given these limitations, in many patients, prospective targeting of LV lead placement may require a direct surgical approach. (Source: Europace)
Source: Europace - October 30, 2009 Category: Cardiology Authors: Khan, F. Z., Virdee, M. S., Gopalan, D., Rudd, J., Watson, T., Fynn, S. P., Dutka, D. P. Tags: Pacing and CRT Source Type: journals

Right ventricular contractility as a measure of optimal interventricular pacing setting in cardiac resynchronization therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion RV dP/dtmax failed to identify the optimal VV interval when compared with LV dP/dtmax and can therefore not be recommended for VV optimization in CRT patients. (Source: Europace)
Source: Europace - October 30, 2009 Category: Cardiology Authors: Sciaraffia, E., Malmborg, H., Lonnerholm, S., Blomstrom, P., Blomstrom Lundqvist, C. Tags: Pacing and CRT Source Type: journals

The use of real-time three-dimensional echocardiography for assessing mechanical synchronicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Real-time three-dimensional echocardiography is a robust technique, which can be used to accurately and effectively assess global and regional mechanical dyssynchrony in heart failure patients. (Source: Heart)
Source: Heart - October 29, 2009 Category: Cardiology Authors: Liodakis, E, Sharef, O A., Dawson, D, Nihoyannopoulos, P Tags: Drugs: cardiovascular system, Echocardiography, Clinical diagnostic tests Original articles Source Type: journals

Interventricular Mechanical Dyssynchrony: Quantification with Velocity-encoded MR Imaging [Cardiac Imaging]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Measurements of interventricular mechanical dyssynchrony obtained by using velocity-encoded MR imaging are equivalent to measurements obtained with pulsed-wave echocardiography and can be used to identify potential responders to cardiac resynchronization therapy. (Source: Radiology)
Source: Radiology - October 28, 2009 Category: Radiology Authors: Muellerleile, K., Baholli, L., Groth, M., Barmeyer, A. A., Koopmann, K., Ventura, R., Koester, R., Adam, G., Willems, S., Lund, G. K. Tags: Cardiac Imaging Source Type: journals

Trial-generated profiles for implantation of electrical devices in outpatients with heart failure: real-world prevalence and 1-year outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions As many as half the IN-CHF outpatients fulfilled current criteria for device implantation. Various subgroups had higher 1-year mortality than patients in trial control arms [ndash] a finding that may not be entirely attributable to differences in drug therapy (especially beta blockers). (Source: Journal of Evaluation in Clinical Practice)
Source: Journal of Evaluation in Clinical Practice - October 27, 2009 Category: Journals (General) Authors: Giuseppe Boriani, Claudio Rapezzi, Igor Diemberger, Lucio Gonzini, Marco Gorini, Donata Lucci, Gianfranco Sinagra, Robin M. T. Cooke, Giuseppe Di Pasquale, Luigi Tavazzi, Aldo P. Maggioni Source Type: journals

EU approves St. Jude's quadripolar pacing systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
St. Jude Medical has received CE Mark approval for its quadripolar pacing system for cardiac resynchronization therapy defibrillators (CRT-D). (Source: Cardiovascular Business News)
Source: Cardiovascular Business News - October 26, 2009 Category: Cardiology Tags: Latest News Source Type: news

Cardiac Resynchronization Induces Major Structural and Functional Reverse Remodeling in Patients With New York Heart Association Class I/II Heart Failure.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions-CRT in patients with New York Heart Association I/II resulted in major structural and functional reverse remodeling at 1 year, with the greatest changes occurring in patients with a nonischemic cause of heart failure. CRT may interrupt the natural disease progression in these patients. Clinical Trial Registration-Clinicaltrials.gov Identifier: NCT00271154. PMID: 19858419 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - October 26, 2009 Category: Cardiology Authors: St John Sutton M, Ghio S, Plappert T, Tavazzi L, Scelsi L, Daubert C, Abraham WT, Gold MR, Hassager C, Herre JM, Linde C, Tags: Circulation Source Type: journals

Early Cardiac Resynchronization Therapy and Reverse Remodeling in Patients With Mild Heart Failure. Is It Time?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19858411 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - October 26, 2009 Category: Cardiology Authors: Francis GS, Tang WH Tags: Circulation Source Type: journals

Cardiac resynchronization therapy in patients with ischemic versus non-ischemic heart failure: Differential effect of optimizing interventricular pacing intervalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Optimized sequential biventricular pacing further increased LV systolic performance as compared to simultaneous stimulation, particularly in ischemic patients where the presence of a large scar was correlated with a larger LV preactivation. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Nina Ajmone Marsan, Gabe B. Bleeker, Rutger J. Van Bommel, Jan Willem Borleffs, Matteo Bertini, Eduard R. Holman, Ernst E. van der Wall, Martin J. Schalij, Jeroen J. Bax Tags: Congestive Heart Failure Source Type: journals

Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepositoryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We have established a biorepository and clinical database composed of patients with electrophysiologic diseases. EPGEN will seek to (1) improve risk stratification, (2) elucidate mechanisms of arrhythmogenesis, and (3) identify novel pharmacologic targets for the treatment of heart rhythm disorders. (Source: American Heart Journal)
Source: American Heart Journal - October 24, 2009 Category: Cardiology Authors: Jason I. Koontz, Daniel Haithcock, Valerie Cumbea, Anthony Waldron, Kristie Stricker, Amy Hughes, Kent Nilsson, Albert Sun, Jonathan P. Piccini, William E. Kraus, Geoffrey S. Pitt, Svati H. Shah, Patrick Hranitzky Tags: Trial Design Source Type: journals

St. Jude Medical Announces European CE Mark Approval And First Implant Of Industry's First Quadripolar Pacing SystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
St. Jude Medical, Inc. (NYSE: STJ) announced it has received European CE Mark approval for the industry's first quadripolar pacing system for cardiac resynchronization therapy defibrillators (CRT-Ds). The quadripolar system offers physicians the ability to more effectively and efficiently manage the ever-changing pacing needs of patients with heart failure. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 22, 2009 Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news

St. Jude Medical Announces European CE Mark Approval And First Implant Of Industry's First Quadripolar Pacing SystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
St. Jude Medical, Inc. today announced it has received European CE Mark approval for the industry's first quadripolar pacing system for cardiac resynchronization therapy defibrillators (CRT-Ds). The quadripolar system offers physicians the ability to more effectively and efficiently manage the ever-changing pacing needs of patients with heart failure (Source: Medical Design Online News)
Source: Medical Design Online News - October 20, 2009 Category: Medical Equipment Source Type: news

Limited Response to Cardiac Resynchronization Therapy in Patients with Concomitant Right Ventricular DysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Limited Response to CRT in Patients with RVD. Introduction: Patients with left ventricular dysfunction (LVD) and LV dyssynchrony may respond to cardiac resynchronization therapy (CRT). However, right ventricular dysfunction (RVD) is a predictor of decreased survival in patients with LVD, and its influence on clinical response to CRT is unknown. The purpose of this study was to examine the effect of RVD on the clinical response to CRT. Methods and Results: A retrospective cohort of consecutive patients who underwent implantation of a CRT implantable cardioverter-defibrillator (ICD) were included and deemed to have RVD based...
Source: Journal of Cardiovascular Electrophysiology - October 19, 2009 Category: Cardiology Authors: PAUL B. TABEREAUX, HARISH DOPPALAPUDI, G. NEAL KAY, H. THOMAS MCELDERRY, VANCE J. PLUMB, ANDREW E. EPSTEIN Source Type: journals

Outcome after device implantation in chronic heart failure is dependent on concomitant medical treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our data stress the importance of professional monitoring and titration of pharmacotherapy not only in medically treated CHF patients but also in patients under device therapy by a heart failure unit or a specialized cardiologist. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - October 15, 2009 Category: Journals (General) Authors: C. Adlbrecht, M. Hülsmann, M. Gwechenberger, G. Strunk, C. Khazen, F. Wiesbauer, M. Elhenicky, S. Neuhold, T. Binder, G. Maurer, I. M. Lang, R. Pacher Source Type: journals

Current practice of cardiac resynchronization therapy (CRT) in the real world: insights from the European CRT surveyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Heart Journal)
Source: European Heart Journal - October 14, 2009 Category: Cardiology Authors: Steffel, J., Hurlimann, D. Tags: ESC hot line Source Type: journals

The European cardiac resynchronization therapy surveyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This CRT survey provides important information describing current European practice with regard to patient demographics, selection criteria, procedural routines, and status at discharge. These data should be useful for benchmarking individual patient management and national practice against wider experience. (Source: European Heart Journal)
Source: European Heart Journal - October 14, 2009 Category: Cardiology Authors: Dickstein, K., Bogale, N., Priori, S., Auricchio, A., Cleland, J. G., Gitt, A., Limbourg, T., Linde, C., van Veldhuisen, D. J., Brugada, J., on behalf of the Scientific Committee and National Coordinators Tags: ESC hot line Source Type: journals

Characteristics of heart failure patients associated with good and poor response to cardiac resynchronization therapy: a PROSPECT (Predictors of Response to CRT) sub-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Sub-analysis of data from PROSPECT showed that gender, aetiology of HF, QRS duration, severity of HF, a history of VT, and the presence of baseline mechanical dyssynchrony influence clinical and/or LV reverse remodelling after CRT. Although integration of information about these characteristics would improve patient selection and counselling for CRT, further randomized controlled trials are necessary prior to changing the current guidelines regarding patient selection for CRT. (Source: European Heart Journal)
Source: European Heart Journal - October 14, 2009 Category: Cardiology Authors: van Bommel, R. J., Bax, J. J., Abraham, W. T., Chung, E. S., Pires, L. A., Tavazzi, L., Zimetbaum, P. J., Gerritse, B., Kristiansen, N., Ghio, S. Tags: ESC clinical trial update Source Type: journals

Large response to cardiac resynchronization therapy in a patient with segmental paradoxical systolic expansion identified by strain imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An 84-year-old man with non-ischaemic cardiomyopathy underwent cardiac resynchronization therapy (CRT) based on the presence of drug-refractory heart failure, depressed left ventricular ejection fraction (25%), and wide QRS complex (160 ms). Longitudinal tissue velocity revealed no significant dyssynchrony (23 ms in Yu index and 35 ms in opposing wall delay). However, longitudinal tissue Doppler strain revealed unique appearances in apical four-chamber and long-axis views. The anterior and inferior septum at basal and mid-levels had reversed strain (becoming positive), indicating paradoxical systolic expansion. Ejection fr...
Source: European Journal of Echocardiography - October 12, 2009 Category: Cardiology Authors: Tanaka, H., Kawai, H., Tatsumi, K., Kataoka, T., Onishi, T., Yoshida, A., Hirata, K.-i. Tags: CASE REPORTS Source Type: journals

Short-Term Hemodynamic Effects of Cardiac Resynchronization Therapy in Patients With Heart Failure, a Narrow QRS Duration, and No Dyssynchrony.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion-Cardiac resynchronization therapy results in an improvement in short-term hemodynamic variables in patients with a QRS <120 ms related to both contractile improvement and relief of external constraint. These findings provide a potential physiological basis for cardiac resynchronization therapy in this patient population. PMID: 19822812 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - October 11, 2009 Category: Cardiology Authors: Williams LK, Ellery S, Patel K, Leyva F, Bleasdale RA, Phan TT, Stegemann B, Paul V, Steendijk P, Frenneaux M Tags: Circulation Source Type: journals

Cardiac Resynchronization Therapy in Patients with Right Ventricular Pacing-Induced CardiomyopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:A CRT upgrade is an effective treatment for RV pacing-induced cardiomyopathy and should be implemented as soon as the diagnosis is established. Unfortunately, about 24% of our patients did not respond to the upgrade. (PACE 2009; 1[ndash]4) (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - October 10, 2009 Category: Cardiology Authors: ALIREZA NAZERI, ALI MASSUMI, ABDI RASEKH, MOHAMMAD SAEED, CHRISTOPHER FRANK, MEHDI RAZAVI Source Type: journals

Is Mechanical Dyssynchrony Assessment Better than Electrocardiogram for Predicting Cardiac Resynchronization Therapy Responder?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiology 2010;115:19-21 (DOI:10.1159/000245658) (Source: Karger Publishers)
Source: Karger Publishers - October 9, 2009 Category: Cancer & Oncology Source Type: journals

SmartDelay Determined AV Optimization: A Comparison of AV Delay Methods Used in Cardiac Resynchronization Therapy (SMART-AV): Rationale and DesignEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:SMART-AV is a randomized, clinical trial designed to evaluate three different methods of AV delay optimization to determine whether systematic AV optimization is beneficial for patients receiving CRT for 6 months post-implant. (PACE 2009; 1[ndash]10) (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - October 9, 2009 Category: Cardiology Authors: KENNETH M. STEIN, KENNETH A. ELLENBOGEN, MICHAEL R. GOLD, BERND LEMKE, IGNACIO FERNÁNDEZ LOZANO, SUNEET MITTAL, FRANCIS G. SPINALE, JENNIFER E. VAN EYK, ALAN D. WAGGONER, TIMOTHY E. MEYER Source Type: journals

Intrathoracic and Ventricular Impedances are Associated with Changes in Ventricular Volume in Patients Receiving Defibrillators for CRTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background:Some implantable cardioverter defibrillators (ICD) are able to monitor intrathoracic impedance to detect pulmonary fluid overload. This is achieved by measuring impedance between the ICD case and the right ventricular (RV) lead. We hypothesized that the measured impedance would rise with improvement in left ventricular (LV) volumes during cardiac resynchronization therapy (CRT), and that such impedance changes would be more apparent when measured with an alternative pacing vector. Methods:We analyzed echocardiographic and impedance data from heart failure patients implanted with a CRT[ndash]ICD capable of intrat...
Source: Pacing and Clinical Electrophysiology : PACE - October 9, 2009 Category: Cardiology Authors: MASSIMILIANO MAINES, MAURIZIO LANDOLINA, MAURIZIO LUNATI, GABRIELE LONARDI, ALESSIA PAPPONE, ALESSANDRO PROCLEMER, GABRIELE ZANOTTO, MASSIMO SANTINI, ANNAMARIA VARBARO, MARCO VIMERCATI, SERGIO VALSECCHI Source Type: journals

Noncontact Mapping of Left Ventricle during CRT ImplantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:An NCM during CRT is safe and feasible. It provides an additional information on electrical activation in SR and in various modality of pacing. Further studies with larger populations are needed in order to correlate electrical to clinical outcomes. (PACE 2009; 1[ndash]11) (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - October 9, 2009 Category: Cardiology Authors: CLAUDIO PRATOLA, PASQUALE NOTARSTEFANO, TIZIANO TOSELLI, PAOLO ARTALE, PAOLO SQUASI, ELISA BALDO, ROBERTO FERRARI Source Type: journals

Usefulness of Brain Natriuretic Peptide Level at Implant in Predicting Mortality in Patients with Advanced But Stable Heart Failure Receiving Cardiac Resynchronization TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Brain natriuretic peptide (BNP) level has emerged as a predictor of death and hospital readmission in patients with heart failure (HF). The value of baseline BNP assessment in advanced HF patients receiving cardiac resynchronization defibrillator therapy (CRT-D) has not been firmly established.We hypothesized that a baseline BNP level would predict all cause mortality and HF hospitalization in HF patients receiving cardiac resynchronization therapy.A retrospective chart review of all patients having BNP assessment prior to implantation of a CRT-D for standard indications during 2004 and 2005 was conducted at the Veterans A...
Source: Clinical Cardiology - October 7, 2009 Category: Cardiology Authors: Aiman El-Saed, Andrew Voigt, Alaa Shalaby Source Type: journals

Cardiac Resynchronization Therapy in Patients With Left Bundle Branch Block Versus Right Ventricular PacingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I read with interest the report by Delnoy et al in the July 1, 2009, issue of The American Journal of Cardiology regarding the long-term clinical and echocardiographic responses to cardiac resynchronization therapy (CRT) in 194 patients with left bundle branch block (LBBB) compared with 90 patients with LBBB-like electrocardiographic patterns due to right ventricular apical pacing (RVP). Although the patients in the 2 groups were different in certain characteristics at baseline (those with RVP had significantly greater ejection fractions and smaller left ventricular volumes), they responded equally well to CRT, showing sim...
Source: The American Journal of Cardiology - October 5, 2009 Category: Cardiology Authors: John E. Madias Tags: Readers' Comments Source Type: journals

Prevention of Disease Progression by Cardiac Resynchronization Therapy in Patients With Asymptomatic or Mildly Symptomatic Left Ventricular Dysfunction: Insights From the European Cohort of the REVERSE (Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction) TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: After 24 months of CRT, and compared with those of control subjects, clinical outcomes and LV function were improved and LV dimensions were decreased in this patient population in New York Heart Association functional classes I or II. These observations suggest that CRT prevents the progression of disease in patients with asymptomatic or mildly symptomatic LV dysfunction. (REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction [REVERSE]; NCT00271154) (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - October 5, 2009 Category: Cardiology Authors: Claude Daubert, Michael R. Gold, William T. Abraham, Stefano Ghio, Christian Hassager, Grahame Goode, Tamás Szili-Török, Cecilia Linde, REVERSE Study Group Tags: cardiac resynchronization therapy Source Type: journals

Is it Time to Expand the Use of Cardiac Resynchronization Therapy to Patients With Mildly Symptomatic Heart Failure?⁎Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiac resynchronization therapy (CRT) is central to the management of patients with highly symptomatic systolic heart failure and delayed ventricular conduction. Improved survival and reduced rates of hospital stay for heart failure with CRT versus standard medical therapy have been documented in prior trials (). Thus, CRT combined with a pacemaker or implantable cardioverter-defibrillator (CRT-D) is now routinely recommended for patients with New York Heart Association (NYHA) functional class III or IV limitation, a QRS duration ≥120 ms, and left ventricular (LV) ejection fraction ≤0.35 despite optimal pharmacologic...
Source: Journal of the American College of Cardiology - October 5, 2009 Category: Cardiology Authors: Derek V. Exner Tags: cardiac resynchronization therapy: Editorial Comment Source Type: journals

Resynchronization Can Slow Heart Failure ProgressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiac resynchronization therapy improves clinical outcomes, as well as left ventricular function and size, in patients with asymptomatic or mildly symptomatic left ventricular dysfunction, according to a study published online Sept. 30 in the Journal of the American College of Cardiology. (Source: Modern Medicine)
Source: Modern Medicine - October 1, 2009 Category: Journals (General) Source Type: info

CRT May Benefit Patients wth Mild Heart Failure (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The progression of heart failure slowed significantly in mildly symptomatic patients who received cardiac resynchronization therapy (CRT), data from a randomized clinical trial showed. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - October 1, 2009 Category: Cardiology Source Type: news