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Malignant primary cardiac tumours
CONCLUSIONS With reference to our case series, we want to draw attention to the rapid deteriation of these patients following presentation. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - November 19, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Burnside, N., MacGowan, S. W. Tags: Adult Cardiac Source Type: research
Primary and metastatic cardiac sarcomas: a 12-year experience at a German heart center.
CONCLUSIONS: Primary and metastatic cardiac sarcomas are very heterogeneous in their histological appearance, clinical presentation and course of the disease. Radical surgery combined with chemoradiation is promising in patients with resectable disease and may significantly prolong survival. Cardiac transplantation represents an emerging strategy for patients with isolated unresectable cardiac involvement. PMID: 23119110 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 15, 2012 Category: Pathology Authors: Agaimy A, Rösch J, Weyand M, Strecker T Tags: Int J Clin Exp Pathol Source Type: research
Characterization of cardiac sarcoma with 2- and 3-dimensional echocardiography, myocardial contrast echocardiography and cardiac magnetic resonance imaging.
PMID: 23129704 [PubMed - in process] (Source: Circulation)
Source: Circulation - November 6, 2012 Category: Cardiology Authors: Bhattacharyya S, Roussin I, Prasad S, Pakrashi T, Khattar R, Judson I, Lyon AR, Sheppard MN, Senior R Tags: Circulation Source Type: research
Complete resection of undifferentiated cardiac sarcoma and reconstruction of the atria and the superior vena cava: case report
Primary cardiac tumors are rare with an incidence ranging from 0.001% to 0.03% in autopsy series. The prognosis of cardiac sarcomas remains poor because it proliferates rapidly and distant metastases are often found at diagnosis. A 47-year-old male complained of persistent cough. The chest roentgenogram was normal. Subsequent computed tomography revealed a mass in the right atrium. Echocardiography and magnetic resonance imaging confirmed also a right atrial mass (34 x 35 mm) infiltrating the atrial septum. The tumor was completely resected en bloc, including the anterior and lateral right atrial walls, the left atrial dom...
Source: Journal of Cardiothoracic Surgery - September 27, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Nobuyuki FurukawaJan GummertJochen Börgermann Source Type: research
Primary cardiac sarcomas may develop from resident or bone marrow‐derived mesenchymal stem cells: use of immunohistochemistry including CD44 and octamer binding protein 3/4
Conclusions: The cytoplasmic positivity for CD44 and the absence of nuclear Oct3/4 suggest that the cells of these sarcomas may represent ‘daughter’ stem cells that no longer have the capacity for tumour initiation, but have subsequently developed new lines of partial differentiation. Primary cardiac sarcomas may arise from mesenchymal stem cells with the ability to generate tumours with multilineage differentiation. (Source: Histopathology)
Source: Histopathology - July 16, 2012 Category: Pathology Authors: Laszlo Hegyi, Khin Thway, Cyril Fisher, Mary N Sheppard Source Type: research
Go Team JB! Celebrities and sporting stars show their support for brave Jo as she battles rarest form of cancer
Jo Bryant, 29, from Horncastle, Lincolnshire, has a cardiac sarcoma heart tumour. Since the diagnosis her friends formed Team JB and enlisted stars such as Cheryl Cole, Gary Barlow and Prince Harry to show their support. (Source: the Mail online | Health)
Source: the Mail online | Health - July 9, 2012 Category: Consumer Health News Source Type: news
A Primary Pericardial Undifferentiated Sarcoma Invading the Right Atrium and Superior Vena Cava
We reported herein a case of 56‐year‐old male farmer with a primary pericardial undifferentiated sarcoma, which was revealed only on echocardiography but not computed tomography. The tumor, which invaded the right atrium and superior vena cava, was not completely resected. (Echocardiography, 2012;**:E1‐E4) (Source: Echocardiography)
Source: Echocardiography - June 5, 2012 Category: Cardiology Authors: Wenjing Bi, Ran Qu, Weidong Ren Source Type: research
A Primary Cardiac Sarcoma Spreading Along the Pacing Leads of a Permanent Pacemaker
An 86-year-old man had sinus node dysfunction, with a dual-chamber pacemaker implanted at another hospital 8 years ago. He was evaluated because of lower leg edema and thrombocytopenia. An echocardiogram revealed a mobile lobulated mass, sized 5.0 × 2.0 cm, attached to the atrial lead (*) in the right atrium (A, Online Video 1), moving through the tricuspid valve during diastole and causing partial obstruction of tricuspid inflow. Another mass of smaller size was attached to the shaft of the ventricular lead (white arrow, B, Online Video 2) The tip of the ventricular lead was embedded in a fixed mass (black arrow) at the ...
Source: Journal of the American College of Cardiology - April 11, 2012 Category: Cardiology Authors: Jo-Nan Liao, I-Ming Chen, An-Hang Yang, Wen-Chung Yu Tags: IMAGES IN CARDIOLOGY Source Type: research
Primary cardiac sarcomas may develop from resident or bone marrow derived mesenchymal stem cells. Use of immunohistochemistry including CD44 and Oct 3/4.
Conclusions: The cytoplasmic positivity for CD44 and the absence of nuclear Oct 3/4 suggest that the cells of these sarcomas may represent ‘daughter’ stem cells that no longer have the capacity for tumour initiation, but have subsequently developed new lines of partial differentiation. Primary cardiac sarcomas may arise from mesenchymal stem cells with the ability to generate tumours with multilineage differentiation.© 2012 Blackwell Publishing Ltd (Source: Histopathology)
Source: Histopathology - April 1, 2012 Category: Pathology Authors: Laszlo HegyiKhin ThwayCyril FisherMary N. Sheppard Source Type: research
Unusual presentation of multiple recurrent cardiac sarcomas as acute acalculous cholecystitis caused by rapid expansion into the right cardiac chamber: report of a case
Abstract Sarcomas are rare malignant cardiac tumors and their prognosis is extremely poor, with a high recurrence rate despite extensive initial surgical resection. The development of therapeutic alternatives looks bleak for recurrent sarcomas, however, and complete surgical resection is crucial for any hope of survival even for the recurrent patients. We herein report the case of a 38-year-old male patient with multiple recurrent cardiac sarcomas causing acute acalculous cholecystitis 20 months after the resection of the primary tumor. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 1...
Source: Surgery Today - November 22, 2011 Category: Surgery Tags: Surgery Today Source Type: research
Cardiac sarcomas: therapeutic options?
Future Cardiology , September 2011, Vol. 7, No. 5, Pages 595-597. (Source: Future Cardiology)
Source: Future Cardiology - September 19, 2011 Category: Cardiology Tags: article Source Type: research
Recurrent Cardiac Intimal (Spindle Cell) Sarcoma of the Left Atrium
PRIMARY CARDIAC TUMORS are roughly 100 to 1,000 times rarer than secondary cardiac neoplasms. About 75% of primary cardiac tumors are benign and 25% malignant. Rarer still is primary spindle cell sarcoma of the heart, with only a handful of cases reported in the literature. Prognosis generally is poor because the role of chemotherapy in this setting remains ill defined, and complete surgical tumor resection often proves to be challenging if not utterly unfeasible because of the tumor's anatomic location. The authors report a unique case of resection of recurrent primary cardiac intimal spindle cell sarcoma. (Source: Journa...
Source: Journal of Cardiothoracic and Vascular Anesthesia - September 16, 2011 Category: Anesthesiology Authors: Zhe Li, Tyken Hsieh, Ali Salehi Tags: Case Reports Source Type: research
Pericardial synovial sarcoma of the heart; is it always worth operating?
We report the case of a 37 year old male patient who presented with intermittent fever, nocturnal sweating and asthenia. Chest X-ray revealed an enlarged cardiac silhouette. Echocardiography identified pericardial effusion and a mass compressing the right ventricle. After percutaneous drainage of the effusion, the mass was not visible and deemed to have been septations of the effusion. Chest computed tomography (CT) did not show the mass visible on the X-ray. At one month follow-up, the pericardial mass was again visible on echocardiography and confirmed by magnetic resonance imaging (MRI). CT-guided biopsy showed malignan...
Source: The Journal of Cardiovascular Surgery - September 14, 2011 Category: Cardiovascular & Thoracic Surgery Authors: Myers P, Konstantinidis S, Karatzas N, Milas F, Panos A Tags: J Cardiovasc Surg (Torino) Source Type: research
Primary cardiac sarcoma mimicking mural thrombus
(Source: European Journal of Echocardiography)
Source: European Journal of Echocardiography - September 12, 2011 Category: Cardiology Authors: Lee, E. Y., Jeon, E. S., Choi, J.-O., Lee, S.-C., Park, S. W., Park, P. W. Tags: IMAGE FOCUS Source Type: research
Primary cardiac synovial sarcoma —A case report—
We report a case of cardiac synovial sarcoma, a very rare primary tumor of the heart. The patient was a 29-year-old man with chief complaint of dyspnea. On echocardiography, a tumor 42 mm in diameter occupying the most space of the left atrium was found. The tumor was obstructed the opening of the mitral valve. He was diagnosed with heart failure due to disturbance of the pulmonary venous return and hemodynamic mitral valve stenosis, and underwent surgery. The tumor was a 5-cm sphere originating in the left atrial posterior wall, and was covered with a sheath and solid. The atrial posterior wall was covered with a peel...
Source: General Thoracic and Cardiovascular Surgery - July 13, 2011 Category: Cardiovascular & Thoracic Surgery Tags: General Thoracic and Cardiovascular Surgery Source Type: research
Primary cardiac angiosarcoma treated by complete tumor resection with cardiac reconstruction
We report a case of right atrial angiosarcoma treated by complete tumor resection with cardiac reconstruction with a bovine pericardium patch. (Source: Heart and Lung)
Source: Heart and Lung - April 30, 2011 Category: Intensive Care Authors: Kyoung Sik Park, Bong Gun Song, Kyeong Sam Ok, Dong Won Park, Hye-Jin Jung, Myoung Ok Kwak, Wook-Hyun Cho, Suk-Koo Choi Tags: Care of Patients with Heart Disease Source Type: research
Primary synovial sarcoma of the heart.
We present a further case. This uncommon malignancy has no specific symptoms during its development, which results in delayed diagnosis. Echocardiography, chest computed tomography, and magnetic resonance imaging can provide effective information about this tumor. With the identification of the characteristic and diagnostic chromosomal abnormality t(X; 18), this malignancy will become increasingly recognized. Synovial sarcoma of the heart requires surgical intervention to improve the prognosis. Adjuvant and/or genetic therapy pre- or postoperation can help prolong life. Chemotherapy is usually recommended as it may benefit...
Source: Cardiology Journal - March 31, 2011 Category: Cardiology Authors: Zhang L, Qian J, Li Z, Jing H Tags: Cardiol J Source Type: research
Primary cardiac low grade sarcomas mimicking myxomas. Pitfall in diagnosis
Abstract: Cardiac sarcomas can resemble myxomas macroscopically and microscopically. These tumours can be easily misdiagnosed unless examined carefully. The presence of spindle cells with mitoses, hypercellular areas the formation of a cellular “cambium” layer beneath the surface and/or an unusual location of the tumour are often helpful in recognizing the true nature of these tumours. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 27, 2011 Category: Pathology Authors: Manjiri Deshmukh, Nicholas Francis, Manuel Galinanes, Keng Ang, Salli Muller, Mary N. Sheppard Tags: Instructive Cases Source Type: research
Outcomes After Right-Side Heart Sarcoma Resection [ORIGINAL ARTICLES: ADULT CARDIAC]
Conclusions The patients with right-side heart sarcoma resection had worse survival after resection than that reported for our patients who underwent resection for left-side heart sarcoma or pulmonary artery sarcoma. Because positive surgical margin status is an independent predictor of reduced survival, induction chemotherapy should considered to enhance resectability in right-side heart sarcoma patients, thus maximizing the possibility of obtaining negative surgical margins. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 22, 2011 Category: Cardiovascular & Thoracic Surgery Authors: Kim, M. P., Correa, A. M., Blackmon, S., Quiroga-Garza, G., Weilbaecher, D., Bruckner, B., Ramlawi, B., Rice, D. C., Vaporciyan, A. A., Reardon, M. J. Tags: Cardiac - other ORIGINAL ARTICLES: ADULT CARDIAC Source Type: research
A primary cardiac sarcoma presenting with superior vena cava obstruction
We describe the case of a 48-year-old man who presented with dyspnea, confusion, and facial swelling with cyanosis. The patient developed life-threatening airway obstruction after administration of anxiolytic. The diagnosis of SVC obstruction secondary to a primary cardiac sarcoma was established based on clinical, radiologic, and post-mortem findings. This is one of very few reported cases of a primary cardiac sarcoma causing SVC obstruction. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - January 31, 2011 Category: Emergency Medicine Authors: Manish Thakker, Tracey Keteepe-Arachi, Ausami Abbas, Graham Barker, Neil Ruparelia, Gearoid T. Kingston, Timothy J. Parke Tags: Case Reports Source Type: research
Primary left ventricular cardiac sarcoma.
PMID: 21154270 [PubMed - in process] (Source: Cardiology Journal)
Source: Cardiology Journal - December 23, 2010 Category: Cardiology Authors: Aggeli C, Lampropoulos K, Kartalis A, Felekos J, Kazazaki C, Aggelis A, Dounis V, Pitsavos C, Stefanadis C Tags: Cardiol J Source Type: research
Clinical and pathological features of high grade primary cardiac osteosarcoma [Case report - Thoracic oncologic]
We report one case of primary cardiac osteosarcoma arising from the left atrium of a 42-year-old woman and analyze its clinical and pathological features. Histopathologic examination revealed the tumor was composed of massive osteoid and cartilaginous differentiation embedded in spindle and polygonal cells with marked cytological and nuclear pleomorphism. The patient was alive without recurrence or metastasis at 20 months after surgery without further adjuvant chemotherapy or radiotherapy. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - December 20, 2010 Category: Cardiovascular & Thoracic Surgery Authors: Ye, Z., Shi, H., Peng, T., Han, A. Tags: Cardiac - other Case report - Thoracic oncologic Source Type: research
Primary right atrial sarcoma
Virendra Bhandari, Pramod Sakhi, Kavita Munjal, Amit V Varma, Rakesh Shishodiya, Vishal K JainJournal of Cancer Research and Therapeutics 2010 6(3):347-349Primary malignant tumors of heart are rare with unfavorable prognosis and are mostly diagnosed on autopsy. They have varied presentation and are difficult to diagnose. Most of the cases are benign and others are sarcomas. Here we present a case of primary cardiac sarcoma which had varied presentation and was undiagnosed due to non specific symptoms. Diagnosis of atrial tumor was confirmed on histopathological examination of tissue obtained after thoracotomy. Being inoper...
Source: Journal of Cancer Research and Therapeutics - November 28, 2010 Category: Cancer & Oncology Authors: Virendra BhandariPramod SakhiKavita MunjalAmit V VarmaRakesh ShishodiyaVishal K Jain Source Type: research
Large primary cardiac sarcoma on the left ventricular free wall: is total excision contraindicated? [Case report - Cardiac general]
In conclusion, an aggressive attempt at volume reduction such as cardiac autotransplantation may relieve the symptoms, even though such surgery would only be palliative. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - October 19, 2010 Category: Cardiovascular & Thoracic Surgery Authors: Hirota, M., Ishikawa, N., Oi, M., Tedoriya, T. Tags: Cardiac - other Case report - Cardiac general Source Type: research
Cardiac tumors are unusual and cardiac malignancy, usually sarcoma, is a very small subset of these. The literature on cardiac sarcomas of the left heart often exhibited multiple operations for local recurrence, which we believed was related to inadequate resection, likely exacerbated by poor anatomic exposure of the posterior heart for complex resection and reconstruction. Since November 1998, we have approached large complex sarcoma of the left atrium or left ventricle using the technique of cardiac explantation, ex vivo tumor resection, and cardiac reconstruction and reimplantation of the heart—cardiac autotransplanta...
Source: Operative Techniques in Thoracic and Cardiovascular Surgery: A Comparative Atlas - August 31, 2010 Category: Cardiovascular & Thoracic Surgery Authors: Shanda H. Blackmon, Michael J. Reardon Tags: Cardiac Surgery - R. Morton Bolman, III, Associate Editor Source Type: research
Long-Term Survival With Heart Transplantation for Fibrosarcoma of the Heart.
We report a case of a 25-year-old woman with sarcoma of the heart who received a transplant and is clinically well after 7 years. We believe that transplantation must be considered in this kind of pathology for selected cases. PMID: 20667366 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - July 31, 2010 Category: Cardiovascular & Thoracic Surgery Authors: Coelho PN, Banazol NG, Soares RJ, Fragata JI Tags: Ann Thorac Surg Source Type: research
Primary cardiac undifferentiated sarcoma: role of intraoperative imprint cytology and frozen section of two cases
Abstract: Primary cardiac tumors are very rare, and a vast majority of such malignant tumors are sarcomas. Associated symptoms are usually vague and nonspecific resulting in a late diagnosis and poorer prognosis. Most cardiac sarcomas have been reported in autopsy series. Although echocardiography may help make a diagnosis of a cardiac sarcoma, histopathological confirmation is quintessential. Presented here are two cases of patients who underwent successful surgery for the removal of a cardiac tumor, along with echocardiographic, cytological, and histopathological findings as well as a compact literature review. In both p...
Source: Cardiovascular Pathology - July 29, 2010 Category: Cardiology Authors: Nesrin Turhan, Zişan Özgüler, Kumral Çağlı, Kerim Çağlı, Zehra Gölbaşı Tags: Original Articles Source Type: research
Long-Term Survival With Heart Transplantation for Fibrosarcoma of the Heart [CASE REPORTS]
We report a case of a 25-year-old woman with sarcoma of the heart who received a transplant and is clinically well after 7 years. We believe that transplantation must be considered in this kind of pathology for selected cases. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - July 27, 2010 Category: Cardiovascular & Thoracic Surgery Authors: Coelho, P. N. M. P., Banazol, N. G. M. A., Soares, R. J. M., Fragata, J. I. G. Tags: Transplantation - heart CASE REPORTS Source Type: research
Systemic therapy for cardiac sarcomas.
Abstract Cardiac sarcomas create 2 risks: local problems and metastatic disease. Most frequently, the histologies are angiosarcoma and high-grade pleomorphic unclassified sarcoma (formerly called MFH or malignant fibrous histiocytoma). There is also a clinical-pathological entity without distinctive histological features of tumors that originate in the pulmonary artery and are referred to as pulmonary artery sarcomas or intimal sarcomas of the pulmonary artery. Conventional wisdom indicates that soft-tissue sarcomas are poorly responsive to chemotherapy. Luckily, that is not the case. Attempts to concentrate on the...
Source: Methodist DeBakey Cardiovascular Journal - July 1, 2010 Category: Cardiology Authors: Ravi V, Benjamin RS Tags: Methodist Debakey Cardiovasc J Source Type: research
Right heart sarcomas.
Abstract Primary cardiac tumors are unusual, and primary cardiac sarcomas constitute a rare subset of these. In cardiac sarcoma, unlike many malignancies, the histologic cell type does appear to affect the treatment options or prognosis in a significant way. The presenting symptoms, treatment options and, indeed, prognosis are largely controlled by the tumor's anatomic location. We have proposed a classification system based on anatomic location that divides cardiac sarcoma into left heart, right heart and pulmonary artery sarcomas. In our experience, right heart sarcoma tends to be bulky, grow in a more exophitic ...
Source: Methodist DeBakey Cardiovascular Journal - July 1, 2010 Category: Cardiology Authors: Vaporciyan A, Reardon MJ Tags: Methodist Debakey Cardiovasc J Source Type: research
Left heart sarcomas.
Abstract Primary tumors of the heart are uncommon, with roughly 75% benign and 25% malignant. Most of the malignant tumors are sarcomas and historically have had a very poor prognosis. These tumors tend to occur in young patients with a mean age of 40 years. Making a diagnosis of cardiac sarcoma can be difficult due to its rarity and the nature of the symptoms. For left heart sarcomas, almost all patients are symptomatic by the time the diagnosis has been made. Symptoms are dependent on the location and the extent of the tumor and are not related to tumor histology; similarly, histologic cell type has not been foun...
Source: Methodist DeBakey Cardiovascular Journal - July 1, 2010 Category: Cardiology Authors: Rice DC, Reardon MJ Tags: Methodist Debakey Cardiovasc J Source Type: research
Primary Cardiac Sarcoma [ORIGINAL ARTICLES: ADULT CARDIAC]
Conclusions Cardiac sarcomas are a distinct, rare subset of soft tissue sarcomas with a poor prognosis. Surgery continues to be the central component of successful management. Future clinical efforts should be directed at developing approaches to permit safe radical excision and, potentially, developing effective adjuvant therapy. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - June 29, 2010 Category: Cardiovascular & Thoracic Surgery Authors: Hamidi, M., Moody, J. S., Weigel, T. L., Kozak, K. R. Tags: Cardiac - other ORIGINAL ARTICLES: ADULT CARDIAC Source Type: research
Case report Cerebral metastasis of a primary heart sarcoma
Primary cardiac sarcomas are exceptionally rare tumours. A brain metastasis of a primary cardiac sarcoma has never been reported before. Although we know lots of primary malignomas spreading to the brain, we never observed cerebral metastases of an atrial spindle cell sarcoma. Cardiac sarcomas are more likely to haematogenously metastasize to the lung or the liver. Here, we describe the case of a young man, who suffered from a cerebral metastasis of a spindle cell sarcoma in the left heart atrium nine years ago. Postoperative whole brain irradiation with 30 Gy was performed. Later on, the patient experienced a local recurr...
Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house - May 7, 2010 Category: Neurosurgery Source Type: research
Cardiac sarcoma presenting as heart failure and diagnosed as recurrent myxoma by echocardiogram
We report a case of an extremely rare high-grade, undifferentiated cardiac sarcoma. The patient with left atrial myxoma resected 8 months ago presented with pneumonia, congestive heart failure, and subsequently diagnosed to have cardiac sarcoma. Transoesophageal echocardiogram played an important role in diagnosis of left atrial mass. High index of suspicion is required to diagnose left atrial tumour as initially it can present as pneumonia or congestive heart failure and left atrial tumours are not always the myxoma. (Source: European Journal of Echocardiography)
Source: European Journal of Echocardiography - April 30, 2010 Category: Cardiology Authors: Patil, H. R., Singh, D., Hajdu, M. Tags: ELECTRONIC PAPERS Source Type: research
[Malignant primary cardiac tumors in childhood and adolescence.]
We report here 3 observations of primary malignant cardiac tumors, 2 cases of sarcoma (angiosarcoma and synovial sarcoma) and 1 case of Burkitt's lymphoma. A precise pathological diagnosis is necessary for the proper management of these patients. For sarcoma, treatment associates surgery and chemotherapy. Surgery should be as complete as possible because of the lack of chemotherapy sensitivity of some sarcomas, mainly angiosarcoma and synovial sarcoma. Therefore, the prognosis of cardiac sarcoma remains poor. For primary cardiac lymphoma, management should not be different from lymphoma in other locations. Chemotherapy is ...
Source: Archives de Pediatrie - March 22, 2010 Category: Pediatrics Authors: Fresneau B, Oberlin O, Brugières L, Valteau-Couanet D, Patte C Tags: Arch Pediatr Source Type: research
Cerebral metastasis of a primary heart sarcoma.
Primary cardiac sarcomas are exceptionally rare tumours. A brain metastasis of a primary cardiac sarcoma has never been reported before. Although we know lots of primary malignomas spreading to the brain, we never observed cerebral metastases of an atrial spindle cell sarcoma. Cardiac sarcomas are more likely to haematogenously metastasize to the lung or the liver. Here, we describe the case of a young man, who suffered from a cerebral metastasis of a spindle cell sarcoma in the left heart atrium nine years ago. Postoperative whole brain irradiation with 30 Gy was performed. Later on, the patient experienced a local re...
Source: Neurologia i Neurochirurgia Polska - February 28, 2010 Category: Neurology Authors: Kuhn SA, Walter J, Petersen I, Mueller U, Reichart R, Kalff R Tags: Neurol Neurochir Pol Source Type: research
Surgical treatment of primary cardiac sarcomas.
PMID: 19876427 [PubMed - in process] (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - October 31, 2009 Category: Cardiology Authors: Blackmon SH, Reardon MJ Tags: Tex Heart Inst J Source Type: research
Treatment and Outcomes in Adult Patients with Primary Cardiac Sarcoma: The British Columbia Cancer Agency Experience
Conclusions Patients with nonmetastatic cardiac sarcoma amenable to complete resection experienced improved survival. However, the high overall rates of disease progression and mortality highlight the need for more effective local and systemic treatments that may be used in conjunction with surgery to improve patient outcomes. Content Type Journal ArticleCategory Bone and Soft Tissue SarcomasDOI 10.1245/s10434-009-0734-8Authors Pauline T. Truong, British Columbia Cancer Agency Radiation Therapy Program, Vancouver Island Centre Victoria BC CanadaStuart O. Jones, British Columbia Cancer Agency Radiation...
Source: Annals of Surgical Oncology - October 15, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: research
Primary sarcoma of the right ventricle: surgical and adjuvant therapy
We describe surgical and adjuvant therapeutic management of a right ventricular (RV) sarcoma and pulmonary artery occlusion. Echocardiographic evaluation of a 39-year-old man with exertional dyspnea revealed a tumor mass in the right ventricle, pulmonary trunk, and bilateral pulmonary arteries. The tumor was resected with concomitant pulmonary valvotomy, but the resection was incomplete. The RV outflow was reconstructed with an allograft patch, and a stentless valve was implanted for pulmonary valvular function. The pulmonary trunk and arteries were enlarged with allograft patches. The tumor was undifferentiated sarcom...
Source: General Thoracic and Cardiovascular Surgery - September 23, 2009 Category: Cardiovascular & Thoracic Surgery Tags: General Thoracic and Cardiovascular Surgery Source Type: research
Delayed left ventricular free-wall rupture after cardiac sarcoma resection.
We report the case of a 38-year-old woman who underwent cardiac sarcoma resection and presented later with spontaneous left ventricular free-wall rupture. The original tumor resection required autotransplantation and a transmitral approach, including partial resection of the inner left ventricular wall. Although the patient did well postoperatively, 3 weeks later she developed a large pericardial effusion with tamponade. Intraoperatively, a portion of the left ventricular free wall ruptured and required repair with a Dacron patch. The patient recovered and was discharged from the hospital 3 weeks later. To our knowledge, t...
Source: Texas Heart Institute Journal - June 27, 2009 Category: Cardiology Authors: Bruckner BA, Saharia A, Aburto J, Reardon MJ Tags: Tex Heart Inst J Source Type: research
Imprint cytology of primary cardiac sarcomas: a report of 3 cases
This study elucidated the cellular characteristics and immunohistochemistry for cardiac sarcomas using imprint smears as an aid to cytopathologic diagnosis. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - May 21, 2009 Category: Pathology Authors: Nobuzo Iwa, Kazuyoshi Masuda, Chikao Yutani, Tadao K. Kobayashi Tags: Original Contributions Source Type: research
[Case report - Cardiac general] Prolonged survival with left atrial spindle cell sarcoma
This report describes a 48-year-old gentleman who underwent multiple surgeries to achieve an 11-year survival since the diagnosis. The operative techniques have been described. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - May 14, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Modi, A., Lipnevicius, A., Moorjani, N., Haw, M. Tags: Case report - Cardiac general Source Type: research
Prolonged survival with left atrial spindle cell sarcoma [Case report - Cardiac general]
This report describes a 48-year-old gentleman who underwent multiple surgeries to achieve an 11-year survival since the diagnosis. The operative techniques have been described. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - May 13, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Modi, A., Lipnevicius, A., Moorjani, N., Haw, M. Tags: Case report - Cardiac general Source Type: research
Primary cardiac sarcoma presenting as shock
We report an adult male who presented to emergency department with shock. Echocardiography revealed a huge right ventricular mass obstructing the right ventricular outflow tract and he underwent emergency resection of the mass. Subsequent histopathology confirmed the diagnosis of fibromyxosarcoma. Primary cardiac sarcoma presenting as circulatory shock is a rare phenomenon. Content Type Journal ArticleDOI 10.1007/s12055-009-0008-xAuthors Rangaraj Ramalingam, Sri Jayadeva Institute of Cardiology Department of Cardiology Bangalore 560069 IndiaNagaraja Moorthy, Sri Jayadeva Institute of Cardiology Department of Cardio...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - April 25, 2009 Category: Cardiovascular & Thoracic Surgery Tags: Indian Journal of Thoracic and Cardiovascular Surgery Source Type: research
Outcomes after surgical resection of cardiac sarcoma in the multimodality treatment era
Conclusions: Multimodal therapy can achieve reasonable survival for patients with resected cardiac sarcomas. Patients with local tumor recurrence or metastatic disease may still benefit from aggressive treatment. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 2, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Faisal G. Bakaeen, Dawn E. Jaroszewski, David C. Rice, Garret L. Walsh, Ara A. Vaporciyan, Steven S. Swisher, Robert Benjamin, Shanda Blackmon, Michael J. Reardon Tags: Acquired Cardiovascular Disease Source Type: research
An Uncommon Cause of Heart Failure: Cardiac Sarcomas in the Left Atrium
A 26-year-old woman presented to our emergency department (ED) with 2 days of progressive dyspnea. The patient presented with general soreness and a productive cough with sputum 1 week before the ED visit. She became febrile 5 days later. The patient was alert and responsive on ED presentation, with an initial temperature of 35.3°C, a heart rate of 117 beats/min, a respiratory rate of 28 breaths/min, a blood pressure of 116/74 mm Hg, and an oxygen saturation of 90% with a 100% non-rebreathing mask. Physical examination revealed engorged jugular veins, bilateral basal crackles over lung fields, muffled heart sounds, and bi...
Source: The Journal of Emergency Medicine - March 8, 2009 Category: Emergency Medicine Authors: Cheng-Hsien Hsieh, Chen-June Seak, Te-Fa Chiu, Jih-Chang Chen, Chih-Huang Li Tags: Visual Diagnosis in Emergency Medicine Source Type: research
Primary cardiac undifferentiated sarcoma of the right atrium presenting with cardiac tamponade
This report illustrates the serial imaging of a primary cardiac undifferentiated sarcoma of the right atrium using echocardiography, chest X-ray, and computed tomography. Transthoracic echocardiography on presentation showed an extensive mass of the right atrial free wall with an impending cardiac tamponade. Symptoms were controlled with pericardiocentesis, pericardial window, and radiotherapy but recurred 8 months later with pleural effusion and tumor spread to the great arteries. Primary cardiac sarcoma (PSC) is a rare and aggressive malignancy that is usually diagnosed late due to its nonspecific symptoms. Cytology and ...
Source: Cardiovascular Pathology - March 1, 2009 Category: Cardiology Authors: Poi Keong Kong, Stasinos Theodorou, Elisabeth Beran, Hardial Singh, Wadih Dimitri Tags: Case Reports Source Type: research
An unusual case of spinal column metastasis after orthotopic transplantation for cardiac sarcoma.
The authors describe a patient who underwent orthotopic cardiac transplantation after an undifferentiated cardiac sarcoma was diagnosed. While receiving immunosuppressive therapy, the patient developed spinal column metastases and cauda equina syndrome requiring surgical decompression and stabilization. This occurred despite an exhaustive search for metastatic disease prior to the transplantation. To the authors' knowledge, this represents the first reported case of an undifferentiated cardiac sarcoma metastasis to the spine. This previously healthy 18-year-old woman presented with a myocardial infarction. Investigatio...
Source: Journal of Neurosurgery.Spine - October 1, 2008 Category: Neurosurgery Authors: McLoughlin GS, Sciubba DM, Ali SK, Weinkauf JG, Fourney DR Tags: J Neurosurg Spine Source Type: research
Stereotactic radiosurgery for a cardiac sarcoma: a case report.
We report a case of a 75-year-old man with a pulmonary artery sarcoma, recurrent following surgical resection. To palliate symptoms of this recurrence, he underwent CyberKnife stereotactic radiosurgery with a clinical and radiographic response of his treated disease. No acute or sub-acute toxicity was seen until the patient's death due to metastatic disease 10 weeks following treatment. The feasibility and short-term safety of this technique are reviewed, with emphasis on the stereotactic planning considerations, such as mediastinal organ movement and radiation tolerance. PMID: 18783285 [PubMed - in process] (Source: T...
Source: Technology in Cancer Research and Treatment - September 13, 2008 Category: Cancer & Oncology Authors: Soltys SG, Kalani MY, Cheshier SH, Szabo KA, Lo A, Chang SD Tags: Technol Cancer Res Treat Source Type: research