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Restenosis after carotid endarterectomy: significance of newly acquired risk factorsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: CRFs acquired during long-term follow-up after CEA may independently contribute to progressive ICA stenosis after endarterectomy. Newly acquired CRFs might be more hazardous than CRFs present prior to CEA. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 18, 2009 Category: Neurology Authors: F. Fluri, F. Hatz, B. Voss, P. A. Lyrer, S. T. Engelter Source Type: journals

Carotid artery stenting vs. endarterectomyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Randomized clinical trials have demonstrated that carotid endarterectomy (CEA) is superior to medical management for stroke prevention in patients with symptomatic and, to a lesser degree, asymptomatic internal carotid artery stenosis. However, large-scale registries have shown that the adverse event rates following CEA are commonly higher than observed in the trials. In the last decade, carotid artery stenting (CAS) has emerged as a less invasive alternative to surgery. In order to address the efficacy of CAS, we performed a meta-analysis of 10 randomized trials comparing CAS with CEA in 4648 mainly symptomatic patients. ...
Source: European Heart Journal - November 14, 2009 Category: Cardiology Authors: Roffi, M., Mukherjee, D., Clair, D. G. Tags: Controversies in cardiovascular medicine series Source Type: journals

[Clinical Picture] Carotid plaque ruptureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A 74-year-old man presented with left-sided monocular visual loss as a result of branch retinal artery occlusion. Carotid ultrasonography showed mild (20%) left carotid artery stenosis but no embolic source was identified. MRI of the carotid artery showed a large atherosclerotic plaque at the origin of the left internal carotid artery, despite only mild luminal stenosis (). Cross-sectional imaging (B-T1 weighted, C-T2 weighted), showed a thin fibrous cap with rupture and a large lipid core (). Carotid endarterectomy was done. In the pathological specimen, a large lipid laden plaque was present () showing evidence of plaque...
Source: LANCET - November 13, 2009 Category: Journals (General) Authors: Niall G Keenan, Mary N Sheppard, David M Nott, Dudley J Pennell, Raad H Mohiaddin Tags: Clinical Picture Source Type: journals

Routine or Selective Carotid Artery Shunting for Carotid Endarterectomy and Different Methods of Monitoring in Selective Shunting.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
PMID: 19910541 [PubMed - as supplied by publisher] (Source: Stroke)
Source: Stroke - November 12, 2009 Category: Neurology Authors: Rerkasem K, Rothwell PM Tags: Stroke Source Type: journals

Systematic Review of Randomized Controlled Trials of Patch Angioplasty Versus Primary Closure During Carotid Endarterectomy.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
PMID: 19910540 [PubMed - as supplied by publisher] (Source: Stroke)
Source: Stroke - November 12, 2009 Category: Neurology Authors: Rerkasem K, Rothwell PM Tags: Stroke Source Type: journals

Carotid Plaque Composition in Chronic Kidney Disease: A Retrospective Analysis of Patients Undergoing Carotid Endarterectomy.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: Our results demonstrate that CKD significantly affects plaque composition in patients with advanced carotid artery stenosis. Enhanced calcification and reduced collagenous plaque may lead to plaque instability and rupture. PMID: 19906548 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - November 9, 2009 Category: Surgery Authors: Pelisek J, Assadian A, Sarkar O, Eckstein HH, Frank H Tags: Eur J Vasc Endovasc Surg Source Type: journals

Ultrasonographic and Perioperative Macroscopic Findings in Acute Carotid Artery Occlusionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Acute ischemic stroke (AIS) may occur both in the acute and chronic internal carotid artery occlusion (ICAo). Thus, it is important to assess the ICAo character when considering the recanalization method. The aim was to assess the agreement between the ultrasonographic (US) and perioperative macroscopic (PM) finding in AIS patients with acute ICAo, undergoing an emergent carotid endarterectomy. In a retrospective, hospital-based study, the set consisted of 47 patients (36 males; age 49-79, mean 63.7 ± 8.5 years). ICAo character was classified as an acute thromboembolus either isolated or in combination with atheroscleroti...
Source: Journal of Neuroimaging - November 5, 2009 Category: Radiology Authors: Roman Herzig, David [Scaron]koloudík, Michal Král, Daniel [Scaron]aňák, Martin Roubec, Ondřej [Scaron]koda, Petr Bachleda, Petr Utíkal, Pavel Havránek, Tomá[scaron] Hrbáč, Milan Fučík, Jana Dvořáčková, J Source Type: journals

Systematic Review of the Perioperative Risks of Stroke or Death After Carotid Angioplasty and Stenting.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: Risks of CAS vary substantially across studies. Risks are overall higher than those of CEA in symptomatic patients. Some factors are likely to help select good candidates for CAS. PMID: 19892997 [PubMed - as supplied by publisher] (Source: Stroke)
Source: Stroke - November 5, 2009 Category: Neurology Authors: Touzé E, Trinquart L, Chatellier G, Mas JL Tags: Stroke Source Type: journals

Revascularization Improves Cognitive Functionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
PHILADELPHIA — Both carotid artery stenting and carotid endarterectomy produced a roughly 50% increase in overall cognitive function in a study of 46 patients undergoing intervention for asymptomatic severe carotid stenosis. (Source: Family Practice News)
Source: Family Practice News - November 1, 2009 Category: Primary Care Authors: MITCHEL L. ZOLER Tags: Neurologic Disorders Source Type: news

Extracranial Blood Flow Distribution During Carotid Surgeryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Objective: The collateral function of the external carotid artery (ECA) for cerebral perfusion in cases of atherosclerotic occlusive disease of the internal carotid artery (ICA) is difficult to assess; for this reason, blood flow measurements were taken during carotid endarterectomy (CEA). (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - October 30, 2009 Category: Surgery Authors: M. Aleksic, J. Brunkwall Tags: Selected abstracts from the November issue of the European Journal of Vascular and Endovascular Surgery Source Type: journals

The Carotid Revascularization Endarterectomy vs. Stenting Trial completes randomization: Lessons learned and anticipated resultsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We present a brief description of the CREST protocol, impediments that were overcome during the trial, salient results from the lead-in phase of the trial, a summary of enrollment activities and characteristics of the final cohort, and a timeline for anticipated results from the randomized phase. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - October 30, 2009 Category: Surgery Authors: Brajesh K. Lal, Thomas G. Brott Tags: Clinical trials update Source Type: journals

Carotid Endarterectomy versus Carotid Angioplasty Cui Bono.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: At the present time, CEA remains the intervention of choice in the management of carotid bifurcation disease. PMID: 19879167 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - October 28, 2009 Category: Surgery Authors: Moore WS Tags: Eur J Vasc Endovasc Surg Source Type: journals

Management of Carotid Dacron Patch Infection: A Case Report Using Median Sternotomy for Proximal Common Carotid Artery Control and In Situ Polytetrafluoroethylene Graftingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report on a 58-year-old male who presented with an enlarging cervical hematoma 3 months following carotid endarterectomy with Dacron patch repair, due to septic disruption of the Dacron patch secondary to presumed infection. The essential features of this case are the control of the proximal common carotid artery gained through a median sternotomy, because the patient was markedly obese with minimal thyromental distance, and the treatment consisting of in situ polytetrafluoroethylene bypass grafting, due to the absence of a suitable autogenous saphenous vein. Median sternotomy is rarely required in case of reinterventio...
Source: Annals of Vascular Surgery - October 27, 2009 Category: Surgery Authors: Giulio Illuminati, Francesco G. Calio', Antonio D'Urso, Gianluca Ceccanei, Maria Antonietta Pacilè Tags: Case Report Abstracts Source Type: journals

Treatment strategy for combined carotid artery stenosis and coronary artery disease: staged or simultaneous surgical procedure?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Patients with combined carotid and coronary arterial diseases pose a high risk of cerebrovascular events, and the treatment of choice with either a simultaneous or a staged surgical procedure remains controversial. The literature of combined carotid and coronary arterial diseases of a recent decade in English was retrieved. Totally 41,901 patients undergoing simultaneous or staged carotid and coronary procedures from 53 reports were included. As a result, carotid endarterectomy plus coronary artery bypass remained the most commonly used procedure for the intervention of combined carotid artery stenosis and coronary art...
Source: The Tohoku Journal of Experimental Medicine - October 24, 2009 Category: Research Authors: Yuan SM, Wu HW, Jing H Tags: Tohoku J Exp Med Source Type: journals

The GALA Trial: Will It Influence Clinical Practice?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The General Anesthesia vs. Local Anesthesia for Carotid Surgery (GALA) trial did not show a difference in 30-day postoperative stroke, myocardial infarction and death rates between patients undergoing carotid endarterectomy (CEA) under local vs. general anesthesia. The present article discusses some limitations of the GALA trial. Firstly, the expected stroke and death rates following CEA is so low, that it was unlikely that the GALA trial would show any significant difference between local and general anesthesia. Secondly, preoperative statin use was not recorded. Thirdly, intraoperative shunt usa ge rates (a possible para...
Source: Vascular and Endovascular Surgery - October 22, 2009 Category: Surgery Authors: Paraskevas, K. I., Mikhailidis, D. P., Bell, P. R.F. Tags: Articles Source Type: journals

Doppler Embolic Signals in Cerebrovascular Disease and Prediction of Stroke Risk. A Systematic Review and Meta-Analysis.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: ES predict stroke risk in acute stroke, symptomatic carotid stenosis, and postoperatively after carotid endarterectomy; in asymptomatic carotid stenosis, data are less robust. In these conditions ES may be useful in risk stratification and in assessing therapeutic efficacy. For other embolic sources, further prospective data are required. PMID: 19850894 [PubMed - as supplied by publisher] (Source: Stroke)
Source: Stroke - October 22, 2009 Category: Neurology Authors: King A, Markus HS Tags: Stroke Source Type: journals

Early acute hemispheric stroke after carotid endarterectomy. Pathogenesis and managementemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  A major stroke after CEA is caused, in most of cases, by the acute ICA occlusion with or without intracerebral embolic occlusion. Reopening of the occluded ICA gives good results when intracerebral vessels are patent and when the occluded ICA is satisfactorily reopened. An algorithm of planned reactions in case of perioperative stroke is finally proposed. Content Type Journal ArticleCategory Clinical ArticleDOI 10.1007/s00701-009-0542-8Authors Giovanni Pappadà, University of Milano-Bicocca, at San Gerardo Hospital Neurosurgery Department via Pergolesi 36 20052 Monza Milan ItalyFrancesco V...
Source: Acta Neurochirurgica - October 20, 2009 Category: Neurology Tags: Acta Neurochirurgica Source Type: journals

Regional vascular surgical units: a practical means of providing specialist servicesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  As substantial changes in disease patterns are unlikely, these data indicate that patients previously diverted elsewhere for therapy are now cared for within the health board region and that further increases in workload may be expected. We suggest that these data mandate the reallocation of resources to fund appropriately staffed and audited regional vascular units. Content Type Journal ArticleCategory Original PaperDOI 10.1007/BF03166910Authors M. R. Kalbassi, Mid-Western Regional Hospital Department of Surgery Limerick IrelandS. Tierney, Mid-Western Regional Hospital Department of Surger...
Source: Irish Journal of Medical Science - October 14, 2009 Category: Journals (General) Tags: Irish Journal of Medical Science Source Type: journals

Retinal Vascular Caliber and Extracranial Carotid Disease in Patients With Acute Ischemic Stroke. The Multi-Centre Retinal Stroke (MCRS) Study.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: In patients with acute stroke, retinal venular widening was strongly associated with ipsilateral severe extracranial carotid disease. Our findings suggest concomitant retinal and cerebral microvascular disease may be present in patients with carotid stenosis or occlusion disease. The pathogenesis of stroke due to carotid disease may thus be partially mediated by microvascular disease. PMID: 19815829 [PubMed - as supplied by publisher] (Source: Stroke)
Source: Stroke - October 7, 2009 Category: Neurology Authors: De Silva DA, Liew G, Wong MC, Chang HM, Chen C, Wang JJ, Baker ML, Hand PJ, Rochtchina E, Liu EY, Mitchell P, Lindley RI, Wong TY Tags: Stroke Source Type: journals

Carotid Endarterectomy under General Anesthesia in ASA Class 3 or 4: A Safe Practice?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
To determine if the American Society of Anesthesiology (ASA) physical status classification negatively impacts outcomes following carotid endarterectomy (CEA). This is a retrospective analysis of prospectively collected data by the Veterans Affairs National Surgical Quality Improvement Program, January 2000 to December 2005, of all patients who underwent CEA repair under general anesthesia. Patients with ASA class of 2, defined as mild systemic disease, were used as the reference for comparison with higher ASA classes: 3 = severe systemic disease or 4 = severe systemic disease that is a constant threat to life. The measur...
Source: Journal of Vascular Surgery - September 28, 2009 Category: Surgery Authors: A. Vettukattil, C. Cryer, R. Macsata, A.N. Sidawy Tags: EVS abstracts Source Type: journals

Cognitive Changes after Surgery versus Stenting for Carotid Artery Stenosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Cognitive function has not been evaluated systematically in the context of carotid endarterectomy (CEA) versus stenting (CAS). Cognitive decline can occur from microembolization or hypoperfusion during CEA or CAS. Revascularization may also improve cognitive dysfunction resulting from chronic hypoperfusion. We compared cognitive outcomes in consecutive asymptomatic patients undergoing CAS or CEA. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - September 28, 2009 Category: Surgery Authors: B.K. Lal, J. Hill, M. Yunes, G. Cruz, Z. Jamil Tags: EVS abstracts Source Type: journals

Carotid Endarterectomy for Asymptomatic Disease: Does Degree of Stenosis Influence Outcome?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In this study, we evaluate our results in asymptomatic patients undergoing CEA and stratify them according to percent stenosis. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - September 28, 2009 Category: Surgery Authors: R.C. Darling, S.O. Roddy, P.S.K. Paty Tags: EVS abstracts Source Type: journals

Variations in the Pharmacological Management of Patients Treated with Carotid Endarterectomy: A Survey of European Vascular Surgeonsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study aimed to assess the current peri-operative practice of European vascular surgeons with respect to antiplatelet and other medications for patients undergoing CEA. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - September 28, 2009 Category: Surgery Authors: M. Hamish, M.S. Gohel, A. Shepherd, N.J. Howes, A.H. Davies Tags: Selected abstracts from the October issue of the European Journal of Vascular and Endovascular Surgery Source Type: journals

Carotid angioplasty and stenting in anatomically high-risk patients: Safe and durable except for radiation-induced stenosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: CAS is as technically feasible, safe, and durable in anatomically high-risk patients as in medically high-risk patients, with similar rates of periprocedural stroke and death and late restenosis. However, patients with radiation-induced stenosis appear to be at an increased risk for restenosis. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - September 28, 2009 Category: Surgery Authors: Susanna H. Shin, Christopher L. Stout, Albert I. Richardson, Richard J. DeMasi, Rasesh M. Shah, Jean M. Panneton Tags: From the Southern Association for Vascular Surgery Source Type: journals

No relationship between significant carotid stenosis and stroke after cardiac surgeryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A large single-center retrospective study finds no association between carotid stenosis and stroke after cardiac surgery. The findings may finally answer the question of whether carotid endarterectomy prior to or during heart surgery provides any benefit. (Source: theHeart.org)
Source: theHeart.org - September 28, 2009 Category: Cardiology Source Type: info

Comment on "Early carotid endarterectomy after intravenous thrombolysis for acute ischaemic stroke, Bartolia MA et al. May 2009".email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
PMID: 19560949 [PubMed - indexed for MEDLINE] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - September 26, 2009 Category: Surgery Authors: Rashid F, Morgan RH, Papp L, Pherwani AD Tags: Eur J Vasc Endovasc Surg Source Type: journals

Variations in the pharmacological management of patients treated with carotid endarterectomy: a survey of European vascular surgeons.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: There appears to be broad consensus between vascular surgeons in the pharmacological management of patients undergoing carotid endarterectomy, although some variations do exist. Further clinical studies may help clarify the optimum management strategy in this patient group. PMID: 19647452 [PubMed - indexed for MEDLINE] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - September 26, 2009 Category: Surgery Authors: Hamish M, Gohel MS, Shepherd A, Howes NJ, Davies AH Tags: Eur J Vasc Endovasc Surg Source Type: journals

No Relationship Between Significant Carotid Stenosis and Stroke After Cardiac Surgeryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
No association was found between carotid stenosis and stroke after cardiac surgery. The study may answer the question of whether carotid endarterectomy before or during heart surgery provides benefit. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 25, 2009 Category: Consumer Health News Tags: Neurology & Neurosurgery Source Type: news

Journal Scan: Fluvastatin and Perioperative Events in Patients Undergoing Vascular Surgery (N Engl J Med 2009;361:980-989.)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The authors reported the results of the DECREASE III trial, a randomized, blinded, placebo-controlled trial of fluvastatin 80 mg daily versus placebo, started prior to surgery (median 37 days), in subjects >age 40 undergoing major aortic, peripheral vascular bypass, or carotid endarterectomy surgery. . . (Source: Cardiosource)
Source: Cardiosource - September 23, 2009 Category: Cardiology Source Type: organizations

Yet Again, CMS Declines to Expand Carotid-Stenting Coverageemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Hopes for expanded Medicare coverage of carotid-stenting procedures beyond patients at high risk for carotid endarterectomy who have symptomatic carotid artery stenosis ≥70% have been swatted down by the CMS. Heartwire (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 17, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

Percutaneous versus surgical revascularization for symptomatic carotid artery diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Stroke is the third leading cause of death worldwide and the number one disease associated with permanent disability. In 2006, the estimated total cost of stroke in the United States was a staggering $60 billion. Significant stenosis of the internal carotid artery is responsible for 10% to 20% of all strokes, and current recommendations suggest that patients with symptomatic carotid artery stenosis undergo revascularization for stroke prevention or risk reduction. Since the 1950s, carotid endarterectomy (CEA) has been the dominant modality of revascularization. However, carotid artery angioplasty, i...
Source: Current Cardiology Reports - September 16, 2009 Category: Cardiology Tags: Current Cardiology Reports Source Type: journals

The Asymptomatic Carotid Emboli Study: study design and baseline resultsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Better methods of identifying which patients with asymptomatic carotid stenosis will develop stroke, are required to improve the risk[ndash]benefit ratio of carotid endarterectomy. A promising method is the detection of asymptomatic embolic signals using transcranial Doppler. Embolic signals predict stroke risk in symptomatic carotid stenosis, but their predictive role in asymptomatic carotid stenosis is uncertain. The Asymptomatic Carotid Emboli Study is a prospective observational study in patients with asymptomatic carotid stenosis[ge]70%. Two 1-h transcranial Doppler recordings from the ipsilateral middle cerebral arte...
Source: International Journal of Stroke - September 15, 2009 Category: Neurology Tags: Clinical trial protocols Source Type: journals

Carotid Endarterectomy Improves Cerebrovascular Reserve Capacity Preferentially in Patients with Preoperative Impairment as Indicated by Asymmetric BOLD Response to Hypercapniaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: CEA resulted in improved CVR in patients with carotid artery disease as shown by the absolute and hemispheric asymmetry of BOLD response to hypercapnia.. These findings show that benefits from recanalisation may go beyond removal of the embolic source, by improving the cerebrovascular reserve. Moreover, hypercapnia BOLD fMRI may be a useful clinical tool in predicting this therapeutic potential in patients with severe carotid artery disease. (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - September 10, 2009 Category: Surgery Authors: S.D. Goode, N. Altaf, D.P. Auer, S.T.R. MacSweeney Tags: Carotid Artery Disease Source Type: journals

[In Context] Lifeline: Martin M Brownemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Martin M Brown graduated from Jesus College, Cambridge, UK, and did most of his clinical training in London, UK. He became interested in clinical trials while working as a research fellow with Henry Barnett and Vladimir Hachinski in London, ON, Canada, on the North American Symptomatic Carotid Endarterectomy Trial, and he now leads the CAVATAS and ICSS carotid intervention trials. He is currently professor of stroke medicine at the UCL Institute of Neurology, University College London, UK, and consultant neurologist at the National Hospital for Neurology and Neurosurgery at Queen Square, London, UK. (Source: Lancet Neurology)
Source: Lancet Neurology - September 7, 2009 Category: Neurology Authors: The Lancet Neurology Tags: In Context Source Type: journals

[Articles] Endovascular treatment with angioplasty or stenting versus endarterectomy in patients with carotid artery stenosis in the Carotid And Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trialemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Endovascular treatment (angioplasty with or without stenting) is an alternative to carotid endarterectomy for carotid artery stenosis but there are scarce long-term efficacy data showing that it prevents stroke. We therefore report the long-term results of the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS). (Source: Lancet Neurology)
Source: Lancet Neurology - September 7, 2009 Category: Neurology Authors: Jörg Ederle, Leo H Bonati, Joanna Dobson, Roland L Featherstone, Peter A Gaines, Jonathan D Beard, Graham S Venables, Hugh S Markus, Andrew Clifton, Peter Sandercock, Martin M Brown, on behalf of the CAVATAS Investigators Tags: Articles Source Type: journals

Carotid Endarterectomy Improves Cerebrovascular Reserve Capacity Preferentially in Patients with Preoperative Impairment as Indicated by Asymmetric BOLD Response to Hypercapnia.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: CEA resulted in improved CVR in patients with carotid artery disease as shown by the absolute and hemispheric asymmetry of BOLD response to hypercapnia.. These findings show that benefits from recanalisation may go beyond removal of the embolic source, by improving the cerebrovascular reserve. Moreover, hypercapnia BOLD fMRI may be a useful clinical tool in predicting this therapeutic potential in patients with severe carotid artery disease. PMID: 19744868 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - September 7, 2009 Category: Surgery Authors: Goode SD, Altaf N, Auer DP, Macsweeney ST Tags: Eur J Vasc Endovasc Surg Source Type: journals

Carotid surgery better long-term than angioplasty and stentsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Results from CAVATAS are in, and they suggest that carotid endarterectomy provides superior long-term outcomes over endovascular treatment. (Source: theHeart.org)
Source: theHeart.org - September 4, 2009 Category: Cardiology Source Type: info

Carotid Surgery Better Long-Term Than Angioplasty and Stentsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Results from CAVATAS are in, and they suggest that carotid endarterectomy provides long-term outcomes superior to those of endovascular treatment. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 4, 2009 Category: Consumer Health News Tags: Neurology & Neurosurgery Source Type: news

Endarterectomy offers durable benefits in carotid artery stenosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Carotid endarterectomy should be the treatment of choice in patients with symptomatic carotid artery stenosis, long-term clinical trial data indicate. (Source: MedWire News - Stroke)
Source: MedWire News - Stroke - September 3, 2009 Category: Neurology Source Type: news

Brown-Sequard-type myelopathy due to cervical disc herniation associated with severe carotid stenosis prompting rapid combined corpectomy and carotid endarterectomy under deep anticoagulant therapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: This case suggests that such a combined carotid endarterectomy and cervical corpectomy with fusion under anticoagulant and antiplatelet therapy is feasible. However, even if the unique clinical presentation of our patient led us to undertake such a surgical strategy, therapeutic decision in patients presenting with both severe carotid stenosis and cervical spinal cord compression should rely on a case-by-case analysis. (Source: The Spine Journal)
Source: The Spine Journal - September 1, 2009 Category: Orthopaedics Authors: Mehdi Laghmari, Benjamin Blondel, Philippe Metellus, Michel Bartoli, Stephane Fuentes, Gregoire Pech-Gourg, Tarek Adetchessi, Henry Dufour, Alain Branchereau, Francois Grisoli Tags: Case Reports Source Type: journals

Safety of Carotid Endarterectomy in Patients Concurrently on Clopidogrelemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: In this series, our results suggest that patients concurrently on clopidogrel can safely undergo CEA without increased risk of hematoma or neurological complications. In view of recent data demonstrating adverse outcomes in patients discontinuing clopidogrel, this study is useful in optimally managing this group of patients. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - August 31, 2009 Category: Surgery Authors: Mark D. Fleming, William M. Stone, Paul Scott, Alyssa B. Chapital, Richard J. Fowl, Samuel R. Money Tags: Clinical Research Source Type: journals

Recanalization of chronic carotid occlusion: case report and review of the literature.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report a case of recanalized internal carotid artery in its extracranial portion. The patient underwent successful carotid endarterectomy. PMID: 19769809 [PubMed - in process] (Source: Vascular)
Source: Vascular - August 31, 2009 Category: Surgery Authors: Matic P, Ilijevski N, Radak S, Kolar J, Radak D Tags: Vascular Source Type: journals

Urgent carotid endarterectomy for patients with unstable symptoms: systematic review and meta-analysis of outcomes.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Current evidence suggests that carotid endarterectomy (CEA) performed within 2 weeks of symptoms produces better long-term results than if it is delayed. Urgent endarterectomy following unstable presentations such as crescendo transient ischemic attack (cTIA) or progressive stroke has been associated with variable results. The evidence for this treatment strategy required reviewing. A systematic review of articles related to urgent CEA between 1980 and 2008 was performed. For cTIA, there was an odds ratio of 5.6 (95% confidence interval 3.3-9.7, p </= .0001) for combined stroke or death compared with surgery for "st...
Source: Vascular - August 31, 2009 Category: Surgery Authors: Patterson BO, Holt PJ, Hinchliffe RJ, Thompson MM, Loftus IM Tags: Vascular Source Type: journals

An Unusual Case of Post-stent Carotid Artery Stenosis with Successful Operative Repair: A Case Reportemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report a symptomatic internal carotid artery restenosis distal to a carotid stent in a 69-year-old man, which resulted in a stroke 6 months post-stenting. It was treated by a successful carotid endarterectomy and explantation of the stent. (Source: EJVES Extra)
Source: EJVES Extra - August 31, 2009 Category: Surgery Authors: H. Mistry, A. Currie, C. Lioupis, M. Tyrrell, D. Valenti Source Type: journals

Patients Undergoing Cardiac Surgery with Asymptomatic Unilateral Carotid Stenoses have a Low Risk of Peri-operative Strokeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: These results challenge the opinion that the presence of a unilateral, asymptomatic carotid stenosis in patients undergoing open cardiac surgery is associated with an increased risk of peri-operative stroke, sufficient to warrant routine prophylactic carotid revascularisation. (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - August 31, 2009 Category: Surgery Authors: D. Baiou, A. Karageorge, T. Spyt, A.R. Naylor Tags: Carotid Artery Disease Source Type: journals

Restenosis More Common After Angioplasty Than Surgeryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Although patients treated for carotid artery stenosis with endovascular treatment are significantly more likely to have restenosis than those treated with carotid endarterectomy, stroke risk for both groups is low, according to two papers from the Carotid And Vertebral Artery Transluminal Angioplasty Study published online Aug. 29 in The Lancet. (Source: Modern Medicine)
Source: Modern Medicine - August 30, 2009 Category: Journals (General) Source Type: info

Long-term Risks Lower for Surgical Treatment of Carotid Stenosis (CME/CE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Carotid endarterectomy was more effective than balloon angioplasty at preventing restenosis and showed a trend toward reducing the risk of stroke, according to two studies reporting on a long-running, randomized trial of treatments for carotid stenosis. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 28, 2009 Category: Cardiology Source Type: news

Hispanics have double the complication rate after carotid surgeryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Minority populations who undergo carotid endarterectomy have poorer 30-day outcomes than whites, including increased mortality and higher rates of stroke. (Source: theHeart.org)
Source: theHeart.org - August 28, 2009 Category: Cardiology Source Type: info

Hispanics have Double the Complication Rate After Carotid Surgeryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Minority populations who undergo carotid endarterectomy have poorer 30-day outcomes than whites, including increased mortality and higher rates of stroke. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 27, 2009 Category: Consumer Health News Tags: Neurology & Neurosurgery Source Type: news

Delirium following vascular surgery: increased incidence with preoperative beta-blocker administration.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: Preoperative administration of beta-blockers is associated with an increased risk of postoperative delirium after vascular surgery. Conversely, preoperative statin administration is associated with a lower risk of postoperative delirium. A randomized prospective controlled trial is required to validate these findings. PMID: 19711147 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - August 26, 2009 Category: Anesthesiology Authors: Katznelson R, Djaiani G, Mitsakakis N, Lindsay TF, Tait G, Friedman Z, Wasowicz M, Beattie WS Tags: Can J Anaesth Source Type: journals