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A novel resveratrol analogue HS-1793 treatment overcomes the resistance conferred by Bcl-2 and is associated with the formation of mature PML nuclear bodies in renal clear cell carcinoma Caki-1 cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bcl-2 protects cancer cells from the apoptotic effects of various chemotherapeutic agents. Inhibition or downregulation of Bcl-2 represents a new therapeutic approach to bypass chemoresistance in cancer cells. Previously we designed and synthesized the resveratrol analogue HS-1793 displaying stronger antitumor efficacy than resveratrol and further demonstrated the HS-1793 resistance conferred by Bcl-2 in human leukemic U937 cells. We undertook this study to determine if HS-1793 treatment can bypass the anti-apoptotic effects of Bcl-2 in human renal cancer cells, with a specific focus on the involvement of promyelocytic...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Jeong SH, Lee JS, Jeong NY, Kim TH, Yoo KS, Song S, Suh H, Kwon TK, Park BS, Yoo YH Tags: Int J Oncol Source Type: journals

Severe thrombocytopenia in a patient with metastatic renal cell carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although very rare, bone marrow carcinosis can occur in patients with mRCC and may present a diagnostic challenge. It is associated with a very poor prognosis. PMID: 19887872 [PubMed - in process] (Source: Onkologie)
Source: Onkologie - November 1, 2009 Category: Cancer & Oncology Authors: Florcken A, Loew A, Koch M, Gebauer B, Dorken B, Riess H Tags: Onkologie Source Type: journals

Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We review whether endometriosis-associated ovarian cancer is a specific entity compared with ovarian cancer not associated with endometriosis, with respect to epidemiology, natural history, and clinical diagnosis; we present a review of the English-language literature for ovarian cancer in endometriosis with respect to these three features. A recent prospective study in Japan directly showed that, during a follow-up of up to 17 years of an ovarian endometrioma cohort (n = 6398), 46 incident ovarian cancers were identified, showing that the ovarian cancer risk was significantly elevated in patients w...
Source: International Journal of Clinical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: International Journal of Clinical Oncology Source Type: journals

Ovarian cancer in endometriosis: molecular biology, pathology, and clinical managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Recent molecular and pathological evidence suggests that endometriosis is a monoclonal, neoplastic disease. Moreover, endometriosis serves as a precursor of ovarian cancer (endometriosis-associated ovarian cancer; EAOC), especially of the endometrioid and clear cell subtypes. Although a variety of molecular events, such as p53 alteration, PTEN silencing, K-ras mutations, and HNF-1 activation, have been identified in EAOC, its precise carcinogenic mechanism remains poorly understood. Our recent data indicate that microenvironmental factors, including oxidative stress and inflammation, play an importan...
Source: International Journal of Clinical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: International Journal of Clinical Oncology Source Type: journals

Aberrant expression of p27Kip1-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the expressions of p27Kip1-interacting proteins, i.e., p27Kip1, Skp2, Cks1, cyclin A, cyclin E, and the Ki-67 labeling index (LI), were analyzed in 25 CCAFs (11 benign and 14 borderline) and 15 CCAF-associated CCAs, and compared with the expression status of each protein in the 23 previously studied endometriosis-associated CCAs. Although aberrant expression of all p27Kip1-interacting proteins was more frequent in the CCAF-associated CCAs than in the benign CCAFs, statistical significance was found only for Cks1 overexpression. The frequencies of p27Kip1 downregulation and overexpression of Skp2 and cycli...
Source: Virchows Archiv - October 23, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Clinical results and histological changes following preoperative interventional treatment of the aggressive subtype of endometrial cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The preoperative intra-arterial chemotherapy and embolization can improve the operability of resection in patients with aggressive subtype of endometrial carcinoma, reduce the expression of PCNA, adjust malignancy of endometrial carcinoma, and improve prognosis. Content Type Journal ArticleDOI 10.1007/s10330-009-0096-5Authors Yongxiu Qiu, Zhongshan Hospital of Traditional Chinese Medicine Department of Gynecology and Obstetrics Zhongshan 528400 ChinaCunlin Chen, The Southern Medical University Department of Gynecology and Obsterics, Nanfang Hospital Guangzhou 510000 ChinaYili Wei, Zhongshan ...
Source: The Chinese-German Journal of Clinical Oncology - October 21, 2009 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: journals

Tumor type and substage predict survival in stage I and II ovarian carcinoma: Insights and implications.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: A subset of ovarian carcinoma patients with an excellent outcome can be identified based on tumor type (endometrioid or mucinous) and stage (Ia or Ib). Type is more reproducibly assigned than grade and identifies a larger cohort of women with stage I/II ovarian carcinoma with favorable outcomes (12.2% vs. 6.5%), and therefore is superior to grade in estimating risk of death from ovarian carcinoma. PMID: 19822358 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 9, 2009 Category: Cancer & Oncology Authors: Köbel M, Kalloger SE, Santos JL, Huntsman DG, Gilks CB, Swenerton KD Tags: Gynecol Oncol Source Type: journals

HERA Requests Applications for Ovarian Cancer StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The HERA Women’s Cancer Foundation, a nationally recognized ovarian cancer nonprofit organization, has announced funding for a study focused on type I ovarian cancer; low-grade serous carcinoma, mucinous carcinoma, malignant Brenner tumor and/or clear cell carcinoma. The research will concentrate on the cause, early detection, treatment, and/or understanding of this disease.Scientists and clinicians of non-profit research, medical service and educational institutions located in the U.S are eligible and encouraged to apply. The one-year award for $100,000 will support direct costs of the project, up to 50 percent of ...
Source: ScanGrants feed - October 8, 2009 Category: Research Authors: HERA Women’s Cancer Foundation Source Type: funding

De Novo Renal Carcinoma in Renal Transplant Recipients: Effect of Early TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The increased risk of tumor in renal transplant recipients leads us to propose extended nephrectomy in the case of suspect lesions in the native kidney. In our patients, 65% of patients had malignant lesions. Good prognosis for these localized tumors justified aggressive therapy even though 35% of transplant recipients were tumor-free. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - October 1, 2009 Category: Transplant Surgery Authors: X. Tillou, M. Demailly, F. Hakami, P.-F. Westeel, F. Saint, J. Petit Tags: Renal Transplantation Source Type: journals

Gene silencing of glypican-3 in clear cell carcinoma of the ovary renders it more sensitive to the apoptotic agent paclitaxel in vitro and in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here that GPC3 was expressed in clear cell carcinoma of the ovary, and not in other carcinomas. To evaluate the phenotype and potential preclinical relevance, we generated an ovarian cancer cell line stably transfected with plasmids encompassing shRNA targeting GPC3. We show that the clear cell carcinoma cell line with silenced GPC3 expression (GPC3 [[minus]]) was more sensitive to paclitaxel than GPC3 (+) cells. In addition, the GPC3 silencing induced sensitization to paclitaxel was associated with the activation of an apoptosis pathway, as shown by flow cytometry. Moreover, we investigated the effect of GPC3 on...
Source: Cancer Science - October 1, 2009 Category: Cancer & Oncology Authors: Tomokazu Umezu, Kiyosumi Shibata, Maiko Shimaoka, Hiroaki Kajiyama, Eiko Yamamoto, Kazuhiko Ino, Akihiro Nawa, Takeshi Senga, Fumitaka Kikkawa Source Type: journals

Microarray analysis of microRNA expression in renal clear cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our study may help to clarify the molecular mechanisms involved in the pathogenesis of RCCC, and miRNAs potentially serve as a novel diagnostic biomarker of RCCC. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - September 14, 2009 Category: Cancer & Oncology Authors: Y. Huang, Y. Dai, J. Yang, T. Chen, Y. Yin, M. Tang, C. Hu, L. Zhang Tags: Original Articles Source Type: journals

Paraneoplastic Humorally Mediated Hypercalcemia Induced by Parathyroid Hormone-Related Protein in Gynecologic Malignancies: A Systematic Review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Humoral hypercalcemia of malignancy (HHM) is a metabolic phenomenon that is mediated by the paraneoplastic secretion of parathyroid hormone-related peptide (PTHrP). Gynecologic malignant neoplasms complicated by HHM have been reported for organs such as the uterus, cervix, ovary, vulva and the vagina. The purpose of our study was to perform a review of the published cases in the literature and, further, to identify parameters with effect on outcome. Among 34 women with gynecologic neoplasms, 22 suffered from ovarian and 6 from uterine malignancies, while 3 had vulvar and another 3 cervical cancer. Furthermore, clear ce...
Source: Onkologie - September 13, 2009 Category: Cancer & Oncology Authors: Savvari P, Peitsidis P, Alevizaki M, Dimopoulos MA, Antsaklis A, Papadimitriou CA Tags: Onkologie Source Type: journals

Renal cell carcinoma with bilateral synchronous adrenal gland metastases: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Patients with bilateral synchronous adrenal metastases should be considered to have disseminated metastatic disease. However, good performance status, the presence of paraneoplastic syndrome and the alleviation of refractory pain are important reasons make an urologist to consider radical nephrectomy in RCC patient with metastases. (Source: Cases Journal)
Source: Cases Journal - September 8, 2009 Category: Journals (General) Source Type: journals

A Cross-over Response to Sequential Use of Sunitinib after Sorafenib in a Patient with Metastatic Renal Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 62-year-old man underwent a right nephrectomy for clear cell carcinoma of the kidney, but relapsed within 1 year with liver metastases. He was initially treated with sorafenib 400mg orally twice a day; a baseline scan revealed a 32mm index liver metastasis (A). Repeated scanning 6 months later showed progression of the liver metastasis increasing to 54mm (B). Sunitinib, 50mg orally once a day, using a regimen of 4 weeks on and 2 weeks off treatment, was substituted. Three months later, repeat scanning showed a response (C), with a reduction in the liver metastasis to 41mm, which is maintained out to 1 year. (Source: Clinical Oncology)
Source: Clinical Oncology - September 7, 2009 Category: Radiology Authors: T.M. Richards, P.N. Plowman, R. Reznek, S.A. Ball Tags: Letters Source Type: journals

Novel intronic germline FLCN gene mutation in a patient with multiple ipsilateral renal neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe here a 64-year-old man with a novel germline mutation in the FLCN gene who presented with 3 phenotypically distinct renal tumors in the same kidney, which were histologically classified as oncocytoma (1.4 cm), oncocytic papillary carcinoma (0.5 cm), and clear cell renal carcinoma (0.8 cm). Genetic analysis of normal kidney tissue revealed a heterozygous germline FLCN mutation (intron 9, IVS9+6 C>T). Additional molecular genetic testing revealed somatic mutations and epigenetic events in genes typically associated with these specific histologic tumor types: oncocytoma harbored a second FLCN mutation (intron 12, ...
Source: Human Pathology - September 7, 2009 Category: Pathology Authors: Zoran Gatalica, Stan L. Lilleberg, Semir Vranic, Eduardo Eyzaguirre, Eduardo Orihuela, Gopalrao Velagaleti Tags: Case Studies Source Type: journals

Cutaneous metastases in renal cell carcinoma: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Renal cell carcinoma is the most common form of malignant renal tumour and is extremely lethal. About 25% of the patients develop metastasis at the time of diagnosis, and in many cases during the course of the disease, affecting the lung, lymphatic ganglions, liver, and bone, with skin metastases being quite rare.A 73-year-old patient, who had undergone surgery for adenocarcinoma in the left kidney 10 years previously, visited the dermatological service due to the appearance of recent, rapidly-developing lesion at the back of his neck. It was decided to remove it surgically. The histological study confirmed clear cell carc...
Source: Cases Journal - August 24, 2009 Category: Journals (General) Source Type: journals

Metastatic renal cell carcinoma managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A broader knowledge of clear cell carcinoma molecular biology has permitted the beginning of a new era in mRCC therapy. Benefits of these novel agents in terms of progression-free and overall survival have been observed in patients with mRCC, and, in many cases, have become the standard of care. Sunitinib is now considered the new reference first-line treatment for mRCC. Despite all the progress in recent years, complete responses are still very rare. Currently, many important issues regarding the use of these agents in the management of metastatic renal cancer still need to be properly addressed. (Source: Int...
Source: International Braz J Urol - August 22, 2009 Category: Urology & Nephrology Source Type: journals

mTOR Is a Promising Therapeutic Target Both in Cisplatin-Sensitive and Cisplatin-Resistant Clear Cell Carcinoma of the Ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: mTOR is frequently activated in clear cell carcinoma and can be a promising therapeutic target in the management of clear cell carcinoma. Moreover, mTOR inhibition by RAD001 may be efficacious as a second-line treatment of recurrent disease in patients previously treated with cisplatin. (Clin Cancer Res 2009;15(17):5404-13). PMID: 19690197 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - August 17, 2009 Category: Cancer & Oncology Authors: Mabuchi S, Kawase C, Altomare DA, Morishige K, Sawada K, Hayashi M, Tsujimoto M, Yamoto M, Klein-Szanto AJ, Schilder RJ, Ohmichi M, Testa JR, Kimura T Tags: Clin Cancer Res Source Type: journals

The VHL Tumor Suppressor: Master Regulator of HIF.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypoxia-Inducible Factors (HIFs) are heterodimeric oxygen-sensitive basic helix-loop-helix transcription factors that play central roles in cellular adaptation to low oxygen environments. The von-Hippel Lindau tumor suppressor (pVHL) is the substrate recognition component of an E3 ubiquitin ligase and functions as a master regulator of HIF activity by targeting the hydroxylated HIF-alpha subunit for ubiquitylation and rapid proteasomal degradation under normoxic conditions. Mutations in pVHL can be found in familial and sporadic hemangioblastomas, clear cell carcinomas of the kidney, heochromocytomas and inherited form...
Source: Current Pharmaceutical Design - August 15, 2009 Category: Drugs & Pharmacology Authors: Haase VH Tags: Curr Pharm Des Source Type: journals

Theoretical model of treatment strategies for clear cell carcinoma of the ovary: Focus on perspectivesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The inhibitors that target HNF-1beta and PLK-Emi1 and their downstream signaling molecules would be evaluated. In addition, the therapy currently used in renal CCC should be considered as an alternative for the present treatments or an attractive therapeutic option for ovarian CCC. The challenges accompanying the recent advance are described in this review article. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - August 10, 2009 Category: Cancer & Oncology Authors: Shozo Yoshida, Naoto Furukawa, Shoji Haruta, Yasuhito Tanase, Seiji Kanayama, Taketoshi Noguchi, Mariko Sakata, Yoshihiko Yamada, Hidekazu Oi, Hiroshi Kobayashi Tags: Anti-Tumour Treatment Source Type: journals

The approach to the patient with paraganglioma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The multidisciplinary management of patients with paragangliomas and pheochromocytomas remains challenging. The cornerstone of excellent multidisciplinary management of such patients is genetic classification and management in a tertiary care referral center. Up to one third of all symptomatic presentations of pheochromocytoma or paraganglioma are due to germline mutations in one of six genes defining multiple endocrine neoplasia type 2, von Hippel-Lindau disease, neurofibromatosis type 1, and the paraganglioma syndromes types 1, 3, and 4. This genetic classification forms the basis early diagnosis and follow-up includ...
Source: The Journal of Clinical Endocrinology and Metabolism - July 31, 2009 Category: Endocrinology Authors: Neumann HP, Eng C Tags: J Clin Endocrinol Metab Source Type: journals

Prognostic Factors and Survival of Renal Clear Cell Carcinoma Patients with Bone Metastases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In our retrospective study the pathological and clinical factors, influencing the survival of 65 renal clear cell carcinoma patients operated for bone metastasis between 1990 and 2008 were examined. Based on Kaplan-Meier curves age, gender, clinical symptoms, pathological fracture, progression to the soft tissues, localization and size of the metastasis, whether the occurrence of multiplex metastases is multiorganic or only located to the skeletal system and the stage and grade of primary renal cancer did not influence the survival. The survival significantly improved if the bone metastases were solitary, low Fuhrman g...
Source: Pathology Oncology Research - July 28, 2009 Category: Pathology Authors: Szendrői A, Dinya E, Kardos M, Szász AM, Németh Z, Ats K, Kiss J, Antal I, Romics I, Szendrői M Tags: Pathol Oncol Res Source Type: journals

Expression of nucleoside transporters, deoxycitidine kinase, ribonucleotide reductase regulatory subunits, and gemcitabine catabolic enzymes in primary ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We first reported that the most relevant genes involved in gemcitabine metabolism are expressed in ovarian carcinoma, and might be associated with more aggressive histotypes. The assessment of the expression levels of RRM2 as marker of clinical outcome deserves further investigation in a larger series of ovarian cancer patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1073-yAuthors Gabriella Ferrandina, Catholic University Department of Oncology Campobasso ItalyValentina Mey, University of Pisa Division of Pharmacology and Chemotherapy, Department of Int...
Source: Cancer Chemotherapy and Pharmacology - July 28, 2009 Category: Cancer & Oncology Tags: Cancer Chemotherapy and Pharmacology Source Type: journals

[Reviews] Lynch syndrome (hereditary non-polyposis colorectal cancer) and endometrial carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women with hereditary non-polyposis colorectal cancer (HNPCC)/Lynch syndrome have a high risk for endometrial cancer (EC) and frequently present with a gynaecological cancer as their first or sentinel malignancy. Identification of these patients is important given their personal and family risk for synchronous and metachronous tumours. Modalities to detect ECs for the possibility of HNPCC include microsatellite instability assay, immunohistochemistry for DNA mismatch repair proteins, MLH1 promoter hypermethylation assay and mutational analysis of DNA mismatch repair genes. The revised Bethesda guidelines provide screening ...
Source: Journal of Clinical Pathology - July 27, 2009 Category: Pathology Authors: Garg, K, Soslow, R A Tags: Reviews Source Type: journals

BRCA2 alteration is important in clear cell carcinoma of the ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BRCA2 has been shown to play a significant role in hereditary ovarian carcinoma. Several cases of clear cell carcinoma (CCC) of the ovary containing BRCA2 mutations have been identified. We hypothesize that sequence variants of the BRCA2 gene are common in CCC of the ovary. Multiple methods were utilized to detect BRCA2 genetic alterations in a cohort of 13 ovarian CCC. These included an LOH analysis for copy number, real-time and methylation-specific polymerase chain reaction (PCR) to probe for BRCA2 promoter methylation, in addition to protein truncation testing (PTT) gel screening for nonsense BRCA2 mutations, and f...
Source: Clinical Genetics - July 27, 2009 Category: Genetics & Stem Cells Authors: Goodheart M, Rose S, Hattermann-Zogg M, Smith B, De Young B, Buller R Tags: Clin Genet Source Type: journals

siRNA targeting Survivin inhibits growth and induces apoptosis in human renal clear cell carcinoma 786-O cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We investigated the inhibitory effect of small interfering RNA (siRNA) targeting Survivin gene on cell proliferation and apoptosis in human renal clear cell carcinoma 786-O cells. qRT-PCR, immunocytochemistry, and Western Blot were used to detect Survivin gene expression in 786-O cells. Cell proliferation was determined by BrdU assay and PCNA expression. Cell apoptosis was analyzed through detection of caspase-3 activity, and the effect of Survivin-siRNA on Bcl-2 gene expression was also examined. Forty-eight hours after transfection, Survivin expression was markedly inhibited at the mRNA and protein level. Downregulat...
Source: Pathology, Research and Practice - July 20, 2009 Category: Pathology Authors: Zhang Y, Chen ZD, Du CJ, Xu G, Luo W Tags: Pathol Res Pract Source Type: journals

Prevalence of Renal Cell Carcinoma in Patients With Autosomal Dominant Polycystic Kidney Disease and Chronic Renal FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The prevalence of RCC was higher in patients with ADPKD and ESRD, with >1 year on dialysis or renal transplantation undergoing nephrectomy according the protocol. It would be 2 to 3 times more frequent than RCC in patients with ESRD alone. The clinician should maintain a high alert of suspicion for RCC in such patients. (Source: Urology)
Source: Urology - July 20, 2009 Category: Urology & Nephrology Authors: Pascal Hajj, Sophie Ferlicot, Walid Massoud, Ayman Awad, Yacine Hammoudi, Bernard Charpentier, Antoine Durrbach, Stéphane Droupy, Gérard Benoît Tags: Oncology Source Type: journals

Enhanced expression of Annexin A4 in clear cell carcinoma of the ovary and its association with chemoresistance to carboplatinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clear cell carcinoma (CCC) of the ovary is known to be highly resistant to platinum-based chemotherapy. The purpose of our study was to identify a candidate protein that is associated with chemoresistance of CCC and to investigate the specific mechanism of chemoresistance conferred by the identified protein. Enhanced expression of Annexin A4 (Anx A4) was identified in ovarian CCC cells using 2-D differential gel electrophoresis (2D-DIGE) and mass spectrometry. Anx A4 levels were elevated in CCC cells compared with non-CCC cells as determined by real-time RT-PCR and Western blot analysis. Immunohistochemical analysis of Anx...
Source: International Journal of Cancer - July 13, 2009 Category: Cancer & Oncology Authors: Ayako Kim, Takayuki Enomoto, Satoshi Serada, Yutaka Ueda, Tsuyoshi Takahashi, Barry Ripley, Takashi Miyatake, Masami Fujita, Chun Man Lee, Koji Morimoto, Minoru Fujimoto, Tadashi Kimura, Tetsuji Naka Source Type: journals

Clear cell carcinoma of the lower urinary tract in a male patient. Presentation and update on histogenesis and managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pathology International)
Source: Pathology International - July 13, 2009 Category: Pathology Authors: Stavros I. Tyritzis, Ioannis Anastasiou, Andreas Petrolekas, Aristoteles Alevizopoulos, Dionysios Mitropoulos, Constantinos A. Constantinides Tags: Letters to the Editor Source Type: journals

Seminal Vesicle Metastasis of Renal Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present an unusual magnetic resonance imaging finding of a 70-year-old man with the seminal vesicle tumor. The patient underwent radical nephrectomy for renal cell carcinoma 4 years ago. Laboratory data, including prostatic-specific antigen, ranged within normal limits. Transrectal needle biopsy disclosed a clear cell carcinoma, which was compatible with the original renal cell cancer. Vesiclectomy was performed. Pathohistologic examination confirmed a metastatic renal cell carcinoma of the seminal vesicle. (Source: Urology)
Source: Urology - July 8, 2009 Category: Urology & Nephrology Authors: Kyosuke Matsuzaki, Yutaka Yasunaga, Satoko Fukuda, Toshitsugu Oka Tags: Images in Clinical Urology Source Type: journals

Clinical parameters linked with malignancy in endometrial polyps.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The prevalence of premalignant and malignant endometrial polyps is very low. Advanced age, menopause, obesity and diabetes increase the risk of endometrial polyp malignancy. PMID: 19591006 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - July 7, 2009 Category: Geriatrics Authors: Gregoriou O, Konidaris S, Vrachnis N, Bakalianou K, Salakos N, Papadias K, Kondi-Pafiti A, Creatsas G Tags: Climacteric Source Type: journals

Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report eight cases of HCCC identified at two academic institutions in six women and two men, ranging in age from 25 to 86 years. Histologically, all cases demonstrated cords, trabeculae, and nests of monomorphic clear cells as well as cells with eosinophilic granular cytoplasm. Mild cellular atypia was occasionally seen and mitoses were very rare. Seven cases demonstrated a hyalinized stroma, and one case, a myxoid stroma. Immunohistochemically, the tumor cells were positive for epithelial markers and negative for desmin and actin. Seven cases were negative for S-100. Cells were also positive for periodic acid...
Source: Head and Neck Pathology - July 6, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

Clear cell carcinoma: Review of its histomorphogenesis and classification as a squamous cell lesionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In current classification schemes, clear cell carcinoma—including both the hyalinized and nonhyalinized variety—is now an accepted subtype of malignant salivary gland tumors. Despite this, the underlying cellular differentiation process leading to the typical histomorphology of this neoplasm remains unclear. This review summarizes and illustrates the histologic, ultrastructural, and immunohistochemical evidence for the underlying squamous cell nature of clear cell carcinoma. Squamous cell differentiation is not an uncommon feature of nonneoplastic and neoplastic lesions of the salivary glands. Clear cell carcinoma need...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - July 1, 2009 Category: ENT & OMF Authors: Irving Dardick, Iona Leong Tags: Oral and Maxillofacial Pathology Source Type: journals

Renal and adrenal tumors with cardiac invasion: immediate surgical results in 14 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: IVC and RA tumor thrombi are more frequent in patients with Wilms' tumor. More postoperative complications are seen in patients with adrenal adenocarcinoma, and the postoperative prognosis is better for patients with Wilms' tumor.FUNDAMENTO: La resección del trombo tumoral en vena cava inferior (VCI) y atrio derecho (AD) aumenta la sobrevida del paciente con cáncer renal/ suprarrenal. OBJETIVO: Evaluar la conducta quirúrgica frente al trombo de la VCI y AD en el tratamiento de los tumores renales y suprarrenales. MÉTODOS: De enero de 1997 a junio de 2007, se evaluaron, retrospectivamente, a 14 pacientes tra...
Source: Arquivos Brasileiros de Cardiologia - June 25, 2009 Category: Cardiology Source Type: journals

Prognostic Implications of Polymorphisms and Interleukin-2 Therapy for Renal Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this issue of The Journal de Martino et al (page 728) describe a retrospective analysis of a cohort of 54 white patients with metastatic clear cell carcinoma of the kidney with single nucleotide polymorphisms (SNPs) in the carbonic anhydrase 9 (CA9) gene. The authors previously demonstrated a correlation with CA9 protein expression and responsiveness to interleukin (IL)-2 therapy, while others have disagreed based on immunohistochemical staining. Institutions with a strong immunotherapy program have suggested an association of CA9 expression and IL-2 response. This hypothesis is currently being prospectively tested in a...
Source: The Journal of Urology - June 14, 2009 Category: Urology & Nephrology Authors: Thomas A. Gardner, Theodore Logan Tags: Editorials Source Type: journals

Characterization of Solid Renal Masses using 64-Slice Multidetector CT ScannerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 64-slice multidetector CT scanner with application of enhancement values correction allows diagnosis of clear cell carcinoma. Also, angiomyolipomas could be identified easily with fat inside at the precontrast scan. (Source: TheScientificWorldJOURNAL: Newly published articles.)
Source: TheScientificWorldJOURNAL: Newly published articles. - June 12, 2009 Category: Science Source Type: journals

Small Renal Masses: Incidental Diagnosis, Clinical Symptoms, and Prognostic FactorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Only some SRMs are benign. The great majority of malign SRMs have good prognosis (low stage and grade, no metastasis) with open or laparoscopic surgical treatment (nephron sparing techniques). Active surveillance is an accepted attitude in selected cases. (Source: Advances in Urology)
Source: Advances in Urology - June 10, 2009 Category: Urology & Nephrology Source Type: journals

Four-arm robotic partial nephrectomy for complex renal cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Robotic partial nephrectomy is a safe and feasible procedure. RPN is a preferred approach for complex renal tumors when NSS is indicated. For complex and technical challenging renal tumors, robotic assistance may provide patients the benefit of minimally invasive surgery. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00345-009-0427-8Authors Yu Gong, Zhejiang University College of Medicine Department of Urology, Second Affiliated Hospital 310009 Hangzhou Zhejiang ChinaChuanjun Du, Zhejiang University College of Medicine Department of Urology, Second Affiliated Hospital 31...
Source: World Journal of Urology - June 5, 2009 Category: Urology & Nephrology Tags: World Journal of Urology Source Type: journals

Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated and Sporadic Clear Cell Carcinoma of the KidneyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent insights into the role of the von-Hippel Lindau (VHL) tumor suppressor gene in hereditary and sporadic clear-cell renal cell carcinoma (ccRCC) have led to new treatments for patients with metastatic ccRCC, although virtually all patients eventually succumb to the disease. We performed an integrated, genome-wide analysis of copy-number changes and gene expression profiles in 90 tumors, including both sporadic and VHL disease-associated tumors, in hopes of identifying new therapeutic targets in ccRCC. We identified 14 regions of nonrandom copy-number change, including 7 regions of amplification (1q, 2q, 5q, 7q, 8q, 12...
Source: Cancer Research - June 1, 2009 Category: Cancer & Oncology Authors: Beroukhim, R., Brunet, J.-P., Di Napoli, A., Mertz, K. D., Seeley, A., Pires, M. M., Linhart, D., Worrell, R. A., Moch, H., Rubin, M. A., Sellers, W. R., Meyerson, M., Linehan, W. M., Kaelin, W. G., Signoretti, S. Tags: cell, Tumor, and Stem cell Biology Source Type: journals

Clear cell carcinoma of the minor salivary gland: an autopsy case with multiple metastases 29 years after the initial surgery and a review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an autopsy case of a tumor with widespread metastases 29 years after initial surgery. At the initial presentation, the patient was a 48-year-old man with a small ulcerative tumor in the right hard palate, and the tumor was excised. Twenty-four years after the initial excision, the first recurrence was detected in the lung. Five years later, the patient died of widespread metastases of the disease at the age of 77. Specimens obtained at the initial excision and at autopsy were very similar histologically and immunohistochemically, and both were clear cell carcinoma of the salivary gland. The patient died of the di...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 1, 2009 Category: ENT & OMF Authors: Kyoko Yamashita, Fumi Kawakami, Yasuaki Nakashima, KenIchiro Murakami Tags: Oral and Maxillofacial Pathology Source Type: journals

Clear cell adenocarcinoma of the urinary bladder: a short review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this short review, we discuss clear cell adenocarcinoma of the urinary bladder, a rare tumor that primarily affects women. The histogenesis of this neoplasm is uncertain; in some tumors the clinicopathologic and histologic features are suggestive of a müllerian origin. Clear cell adenocarcinoma consists of cells with abundant clear cytoplasm, arranged in solid, glandular, or tubulocystic patterns. These tumors are positive for pancytokeratin, cytokeratin 7, and CA 125 immunohistochemical stains. Patients typically present with gross hematuria, dysuria, and discharge. The natural history is poorly understood and...
Source: Archives of Pathology and Laboratory Medicine - May 31, 2009 Category: Laboratory Medicine Authors: Adeniran AJ, Tamboli P Tags: Arch Pathol Lab Med Source Type: journals

Minimizing tumor burden by extensive cytoreductive surgery decreases postoperative venous thromboembolism in ovarian clear cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Minimizing residual tumor by extensive cytoreductive surgery with peri-operative thromboprophylaxis may decrease the incidence of a postoperative VTE in patients with OCCC. Larger, prospective studies are needed to confirm these preliminary findings. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-009-1120-2Authors Myong Cheol Lim, National Cancer Center Center for Uterine Cancer, Research Institute and Hospital 111 Jungbalsan-ro, Ilsandong-gu Goyang-si Gyeonggi-do 410-769 KoreaHee Seok Lee, National cancer Center Center for Lung Cancer, Research Institute and Hospita...
Source: Archives of Gynecology and Obstetrics - May 21, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Prognostic significance of histological grade in clear-cell carcinoma of the ovary: a retrospective study of Korean Gynecologic Oncology GroupEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The stage, residual tumor, and universal grade were significant prognostic factors in patients with CCC of the ovary. The universal grading system is applicable in determining prognosis of CCC of the ovary. Further clinical trials for optimal chemotherapy are in need. (Source: Annals of Oncology)
Source: Annals of Oncology - May 21, 2009 Category: Cancer & Oncology Authors: Ryu, S.-Y., Park, S.-I., Nam, B.-H., Kim, I., Yoo, C. W., Nam, J.-H., Lee, K. H., Cho, C.-H., Kim, J.-H., Park, S. Y., Kim, B.-G., Kang, S.-B. Tags: gynecologic tumors Source Type: journals

The lack of correlation between mast cells and microvessel density with pathologic feature of renal cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The MC count was not associated with tumor status such as tumor stage, size, grade, and other clinicopathologic parameters, however, MCs may be related to tumor angiogenesis and acceleration of tumor growth in RCC and therefore need further evaluation in RCC. Content Type Journal ArticleCategory Urology - Original PaperDOI 10.1007/s11255-009-9577-2Authors Mohammad Ghassem Mohseni, University of Tehran Department of Urology Sina Hospital, Hassan Abad Square, Hafez Street 113674911 Tehran IranAbdolreza Mohammadi, University of Tehran Department of Urology Sina Hospital, Hassan Abad Square, H...
Source: International Urology and Nephrology - May 16, 2009 Category: Urology & Nephrology Tags: International Urology and Nephrology Source Type: journals

Initial Experience with the Radiotracer Anti-1-amino-3-[18F]Fluorocyclobutane-1-Carboxylic Acid (Anti-[18F]FACBC) with PET in Renal CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In this small patient sample, relative amino acid transport compared with renal cortex is elevated in renal papillary cell carcinoma but not in clear cell carcinoma. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0220-5Authors David M. Schuster, Emory University Department of Radiology, Division of Nuclear Medicine Atlanta GA USAJonathon A. Nye, Emory University Department of Radiology, Division of Nuclear Medicine Atlanta GA USAPeter T. Nieh, Emory University Department of Urology Atlanta GA USAJohn R. Votaw, Emory University Department of Radiology, Division o...
Source: Molecular Imaging and Biology - May 16, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Clear cell carcinoma originating from ectopic thymusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Cancer of the mediastinum is known to be a relatively rare disease, and clear cell carcinoma in the mediastinum is especially rare. Ectopic thymus is not uncommon, but clear cell carcinoma originating from ectopic thymus has never been reported. We report a case of clear cell carcinoma originating from ectopic thymus in which there was a good response to steroid-supplemented chemoradiotherapy. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11748-008-0354-4Authors Masaya Okuda, Kagawa University Department of General Thoracic, Breast, and Endocrinological Surgery, Faculty of Medicin...
Source: General Thoracic and Cardiovascular Surgery - May 14, 2009 Category: Cardiovascular & Thoracic Surgery Tags: General Thoracic and Cardiovascular Surgery Source Type: journals

[Treatment of metastatic renal cancer: current validity of immunotherapy]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Currently, after the advent of new drugs, use of conventional immunotherapy may be indicated for specific patients with a good general condition undergoing previous nephrectomy for a clear cell carcinoma at least 12 months before occurrence of metastasis in a single organ, preferably the lung, and with normal levels of hemoglobin, calcium, and lactate dehydrogenase, looking for that small percentage of stable and sustained responses. PMID: 19658313 [PubMed - in process] (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - April 30, 2009 Category: Urology & Nephrology Authors: Llarena Ibarguren R Tags: Actas Urol Esp Source Type: journals

Targeted Therapies: Bevacizumab and interferon-α in metastatic renal-cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Targeted Therapies: Bevacizumab and interferon-α in metastatic renal-cell carcinoma Nature Reviews Clinical Oncology 6, 253 (2009). doi:10.1038/nrclinonc.2009.45 Author: Ronald M. Bukowski Rini and colleagues provide additional data on bevacizumab and interferon-α in clear-cell carcinoma of the kidney; a comparison of these results with the findings from contemporary trials suggests that bevacizumab and interferon-α is another clinically useful treatment option for patients with metastatic renal-cell carcinoma. (Source: Nature Clinical Practice Oncology)
Source: Nature Clinical Practice Oncology - April 24, 2009 Category: Cancer & Oncology Authors: Ronald M. Bukowski Tags: News and Views Source Type: journals

Primary lung clear cell carcinoma: one case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s10330-009-0029-3Authors Li Duan, Huazhong University of Science and Technology Department of Cardiac and Thoracic Surgery, Tongji Hospital, Tongji Medical College Wuhan 430030 ChinaTiecheng Pan, Huazhong University of Science and Technology Department of Cardiac and Thoracic Surgery, Tongji Hospital, Tongji Medical College Wuhan 430030 ChinaXiang Wei, Huazhong University of Science and Technology Department of Cardiac and Thoracic Surgery, Tongji Hospital, Tongji Medical College Wuhan 430030 ChinaMin Hu, Huazhong University of Science and Technology Department of Cardiac and Tho...
Source: The Chinese-German Journal of Clinical Oncology - April 21, 2009 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: journals

Aberrant adrenocortical tissue in hernia sac occurring in an adult: case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a rare case of aberrant adrenocortical tissue in hernial sac. We review the literature and highlight the clinical implications of this incidental finding. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10029-009-0501-6Authors D. El Demellawy, Northern Ontario School of Medicine Department of Pathology and Laboratory Medicine, William Osler Health Center, Brampton Civic Hospital 2100 Bovaird East Drive Brampton ON CanadaA. Nasr, University of Toronto Department of Pediatric Surgery, Sick Kids Hospital Toronto ON CanadaA. Samkari, McMaster University Department of Pathology and Molecular Medicin...
Source: Hernia - April 15, 2009 Category: Sports Medicine Tags: Hernia Source Type: journals