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Exercise programs for children with cystic fibrosis: A systematic review of randomized controlled trials.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. There is some evidence to support that both aerobic and strength training can impact positively on pulmonary function, aerobic fitness, and strength. More RCTs in this area would be welcomed. There is potential for future research into designing exercise programs for children with CF using a combination of modalities. PMID: 19925275 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - November 21, 2009 Category: Rehabilitation Authors: van Doorn N Tags: Disabil Rehabil Source Type: journals

Antioxidant found in vegetables has implications for treating cystic fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists have discovered that a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body's inflammatory response to infection and injury. The finding has implications for such inflammation-based disorders as cystic fibrosis, diabetes, heart disease and neurodegeneration. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 21, 2009 Category: Science Source Type: news

Role of Toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pseudomonas aeruginosa is a leading cause of hospital-acquired pneumonia and an important pathogen in patients with chronic lung disease, such as cystic fibrosis and bronchiectasis. The contribution of Toll-like receptor 5 (TLR5) to the innate immune response to this organism is incompletely understood. We exposed wild-type and TLR5-deficient (Tlr5–/–) mice to aerosolized P. aeruginosa at low and high inocula and assessed bacterial clearance, lung inflammation, and cytokine production 4 and 24 h after infection. Bacterial clearance was impaired in Tlr5–/– mice after low-inoculum, but not high-inocul...
Source: AJP: Lung Cellular and Molecular Physiology - November 21, 2009 Category: Respiratory Medicine Authors: Morris, A. E., Liggitt, H. D., Hawn, T. R., Skerrett, S. J. Tags: ARTICLES Source Type: journals

Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides the first direct measurements of ASL depth in intact human airways and indicates the involvement of ENaC sodium channels and CFTR chloride channels in determining ASL depth. We suggest that CF lung disease may be caused by the inability of CFTR-deficient airways to increase their ASL depth transiently following secretory stimuli that in non-CF airways produce transient increases in ASL depth. (Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - November 21, 2009 Category: Respiratory Medicine Authors: Song, Y., Namkung, W., Nielson, D. W., Lee, J.-W., Finkbeiner, W. E., Verkman, A. S. Tags: ARTICLES Source Type: journals

Perioperative Management of the Adult with Cystic Fibrosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since cystic fibrosis (CF) was first differentiated from celiac disease in 1938, the medical care of patients with CF has substantially improved. These improvements have resulted in a significant increase in median survival and the quality of life experienced by patients. The resultant increase in survival has caused the "average" CF patient to be a young adult and not a child. The gene that causes CF was first identified in 1989 and is the first gene discovered by positional cloning. Unfortunately, gene therapy for CF has not been successful, although it continues to hold great promise for future patient care. Althoug...
Source: Anesthesia and Analgesia - November 20, 2009 Category: Anesthesiology Authors: Huffmyer JL, Littlewood KE, Nemergut EC Tags: Anesth Analg Source Type: journals

Vote for Cystic Fibrosis Worldwide to change the lives of thousands who suffer with CFEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - November 20, 2009 Category: Respiratory Medicine Tags: Fundraising Source Type: organizations

Evaluation of the upper airway in children and adolescents with cystic fibrosis and obstructive sleep apnea syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Bone and soft tissue structural alterations of the upper airway and chronic rhinosinusitis were associated with the OSAS group patients. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - November 20, 2009 Category: ENT & OMF Authors: Regina Terse Trindade Ramos, Cristina Salles, Paloma Baiardi Gregório, Alessandro Tunes Barros, Angélica Santana, José Bouzas Araújo-Filho, Angelina Xavier Acosta Tags: Research papers Source Type: journals

Exome-Sequencing Might Help Identify Genetic Cause Of Thousands Of DisordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For the first time, scientists have successfully used a method called exome sequencing to quickly discover a previously unknown gene responsible for a mendelian disorder. Mendelian disorders, such as cystic fibrosis and sickle cell disease, are the result of one or more mutations in a single gene, typically a gene that makes a protein. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: cystic fibrosis Source Type: news

Exome-Sequencing Might Help Identify Genetic Cause Of Thousands Of DisordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For the first time, scientists have successfully used a method called exome sequencing to quickly discover a previously unknown gene responsible for a mendelian disorder. Mendelian disorders, such as cystic fibrosis and sickle cell disease, are the result of one or more mutations in a single gene, typically a gene that makes a protein. All of the regions that code for proteins taken together are called the exome. (Source: Cystic Fibrosis News From Medical News Today)
Source: Cystic Fibrosis News From Medical News Today - November 20, 2009 Category: Respiratory Medicine Tags: cystic fibrosis Source Type: news

Procter & Gamble recalls one batch of Vicks Sinex Micromist 15ml nasal sprayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: MHRA, BBC Health News Area: News Proctor & Gamble (Health & Beauty Care) Ltd is carrying out a precautionary recall on one batch of Vicks Sinex Micromist 15 ml Nasal Spray (batch number 9224028832, expiry 12 August 2013) at wholesale and pharmacy level. This is due to the detection of bacterial contamination with Burkholderia cepacia during routine testing of a batch in the US. The UK batch was derived from the same bulk batch as the US batch. No bacterial contamination has been detected in UK packs. Proctor & Gamble is recalling this batch as a precautionary measure while testing is ongoing and the ca...
Source: NeLM - News - November 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

Sponsor Information for the 1st CF Worldwide Middle East Regional ConferenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - November 19, 2009 Category: Respiratory Medicine Tags: Conferences Source Type: organizations

CFTR fragments with the F508 deletion exert a dual allosteric control over the master kinase CK2.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cystic Fibrosis (CF) mostly follows a single F508 deletion in CFTR (ΔF508), thereby causing premature fragmentation of the nascent protein with concomitant alterations of diverse cellular functions. We show that CK2, the most pleiotropic protein kinase, undergoes allosteric control of its different cellular forms in the presence of short CFTR peptides encompassing the F508 deletion: these ΔF508 peptides drastically inhibit the isolated catalytic subunit (α) of the kinase and yet up-regulate the holoenzyme, composed of two catalytic and two non catalytic (β) subunits. Remarkable agreement between...
Source: BJ Disease - November 19, 2009 Category: Biochemistry Authors: M A Pagano, O Marin, G Cozza, S Sarno, F Meggio, K J. Treharne, A Mehta, L A Pinna Tags: BJ Signal Source Type: journals

Broccoli helps those with cystic fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PHILADELPHIA, Nov. 18 (UPI) -- Thiocyanate -- an anti-oxidant found in broccoli and cauliflower -- may help those with cystic fibrosis, U.S. researchers found. (Source: Health News - UPI.com)
Source: Health News - UPI.com - November 18, 2009 Category: Consumer Health News Source Type: news

Prevention of Essential Fatty Acids Deficiency as a Part of Nutrition Therapy in Patients with CFEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - November 18, 2009 Category: Respiratory Medicine Tags: Newsletter Source Type: organizations

Sixty Five Roses: A Sister's MemoirEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - November 18, 2009 Category: Respiratory Medicine Tags: Newsletter Source Type: organizations

Antioxidant Found In Vegetables Has Implications For Treating Cystic FibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists at the University of Pennsylvania School of Medicine discovered that a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body's inflammatory response to infection and injury. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: cystic fibrosis Source Type: news

Antioxidant Found In Vegetables Has Implications For Treating Cystic FibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists at the University of Pennsylvania School of Medicine discovered that a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body's inflammatory response to infection and injury. The finding has implications for such inflammation-based disorders as cystic fibrosis (CF), diabetes, heart disease, and neurodegeneration. (Source: Diabetes News From Medical News Today)
Source: Diabetes News From Medical News Today - November 18, 2009 Category: Endocrinology Tags: cystic fibrosis Source Type: news

Aradigm Doses First Patient In Long-Term Phase 2 Study Of A Novel Inhaled Ciprofloxacin Formulation For The Management Of Respiratory InfectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aradigm Corporation (OTCBB:ARDM) (the "Company") announced that the first patient was dosed in a 6-month, multicenter, international Phase 2 clinical trial of a novel version of inhaled ciprofloxacin (ARD-3150) in 40 adult patients with non-cystic fibrosis bronchiectasis. The randomized, double-blind, placebo-controlled trial will be conducted in Australia and New Zealand. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

Aradigm Doses First Patient In Long-Term Phase 2 Study Of A Novel Inhaled Ciprofloxacin Formulation For The Management Of Respiratory InfectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aradigm Corporation (OTCBB:ARDM) (the "Company") announced that the first patient was dosed in a 6-month, multicenter, international Phase 2 clinical trial of a novel version of inhaled ciprofloxacin (ARD-3150) in 40 adult patients with non-cystic fibrosis bronchiectasis. The randomized, double-blind, placebo-controlled trial will be conducted in Australia and New Zealand. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)
Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today - November 18, 2009 Category: Infectious Diseases Tags: Respiratory / Asthma Source Type: news

[Chronic Cough in Children - What to Consider and how to Evaluate?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is a long list of differential diagnoses for chronic cough lasting longer than 4 weeks in children. Diagnostic work up starts with a detailed history taking and a clinical investigation followed by a chest X-ray (in one plane) and a spirometry. For the latter reliable results can be achieved by children older then 5 years. If the diagnostic work up is still inconclusive and if the child is in good clinical condition, a 4 weeks' course of inhalation therapy with steroids and betamimetics together with a 2 weeks' course of antibiotics with a macrolide is warranted. In case coughing persists a thorough diagnostic wo...
Source: Praxis - November 18, 2009 Category: Journals (General) Authors: Iseli P Tags: Praxis (Bern 1994) Source Type: journals

Antioxidant Has Implications for Treating Cystic FibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An antioxidant found in vegetables may help treat inflammation-based disorders like cystic fibrosis, according to a new NIGMS-supported study. (Source: NIGMS - Results)
Source: NIGMS - Results - November 17, 2009 Category: Biomedical Science Source Type: news

Clinical trial for cystic fibrosis drugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SALT LAKE CITY, Nov. 16 (UPI) -- A new drug undergoing a clinical trial at the University of Utah could help some cystic fibrosis patients' daily life and longevity, researchers said. (Source: Health News - UPI.com)
Source: Health News - UPI.com - November 16, 2009 Category: Consumer Health News Source Type: news

Granulomatous Dermatitis With Pseudoxanthoma Elasticum-Like Changes: Report of a Case in a Patient With Cystic Fibrosis [Observation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions There are few publications that document PXE-like changes in association with various inflammatory skin conditions. Thus, the clinical significance of this finding remains uncertain. This case and previous reports are discussed in the context of current molecular and genetic knowledge. It is hoped that greater awareness of this phenomenon will promote further investigation and elucidation of the clinical and biologic significance of PXE-like changes observed in biopsies of inflammatory skin disorders. (Source: Archives of Dermatology)
Source: Archives of Dermatology - November 16, 2009 Category: Dermatology Authors: Tiger, J. B., McKenzie, J., Tran, D. T., Olerud, J. E., George, E. Tags: Dermatology, Dermatologic Disorders, Granulomas, Pulmonary Diseases, Pulmonary Diseases, Other, Dermatologic Disorders, Other, Gastroenterology, Liver/ Biliary Tract/ Pancreatic Diseases, Genetics, Genetic Disorders Observation Source Type: journals

Aquagenic Wrinkling of the Palms in Cystic Fibrosis: Comparison With Controls and Genotype-Phenotype Correlations [Observation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results confirm the association between AWP and CF. Among patients with CF, greater AWP occurs in those who are homozygous for the F508 mutation. (Source: Archives of Dermatology)
Source: Archives of Dermatology - November 16, 2009 Category: Dermatology Authors: Berk, D. R., Ciliberto, H. M., Sweet, S. C., Ferkol, T. W., Bayliss, S. J. Tags: Dermatology, Dermatologic Disorders, Pulmonary Diseases, Pulmonary Diseases, Other, Dermatologic Disorders, Other, Gastroenterology, Liver/ Biliary Tract/ Pancreatic Diseases, Genetics, Genetic Disorders Observation Source Type: journals

Expression and Distribution of Cystic Fibrosis Transmembrane Conductance Regulator in Neurons of the Human BrainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates widespread and abundant expression of CFTR in neurons of the human brain. Techniques of double labeling and evaluation of consecutive tissue sections localized CFTR protein and mRNA signals to the cytoplasm of neurons in all regions of the brain studied, but not to glial cells. The presence of CFTR in central neurons not only provides a possible explanation for the neural symptoms observed in CF patients, but also may lead to a better understanding of the functions of CFTR in the human brain. This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article onlin...
Source: Journal of Histochemistry and Cytochemistry - November 16, 2009 Category: Biochemistry Authors: Guo, Y., Su, M., McNutt, M. A., Gu, J. Tags: Articles Source Type: journals

Genomic, Tissue Expression, and Protein Characterization of pCLCA1, a Putative Modulator of Cystic Fibrosis in the PigEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent studies have identified members of the CLCA (chloride channels, calcium-activated) gene family as potential modulators of the cystic fibrosis (CF) phenotype, but differences between the human and murine CLCA genes and proteins may limit the use of murine CF models. Recently established pig models of CF are expected to mimic the human disease more closely than the available mouse models do. Here, we characterized the porcine CLCA gene locus, analyzed the expression pattern and protein processing of pCLCA1, and compared it to its human ortholog, hCLCA1. The porcine CLCA gene family is located on chromosome 4q25, with ...
Source: Journal of Histochemistry and Cytochemistry - November 16, 2009 Category: Biochemistry Authors: Plog, S., Mundhenk, L., Klymiuk, N., Gruber, A. D. Tags: Articles Source Type: journals

The Importance of Sweat Testing for Older Siblings of Patients with Cystic Fibrosis Identified by Newborn ScreeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report cystic fibrosis (CF) care center instructions for sweat testing in older siblings after implementation of the French nationwide newborn screening program, and we evaluate the incidence of unrecognized CF. Nearly 9% of families with an infant screened for CF were unaware of an affected older sibling. We strongly recommend sweat testing for all first-degree older children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 16, 2009 Category: Pediatrics Authors: Anne Munck, Elise Houssin, Michel Roussey Tags: Clinical and Laboratory Observations Source Type: journals

Penn study finds that antioxidant found in vegetables has implications for treating cystic fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(University of Pennsylvania School of Medicine) Scientists at the University of Pennsylvania School of Medicine discovered that a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body's inflammatory response to infection and injury. The finding has implications for such inflammation-based disorders as cystic fibrosis, diabetes, heart disease and neurodegeneration. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 16, 2009 Category: Global & Universal Source Type: news

Diabetes as a Determinant of Mortality in Cystic Fibrosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Diabetes is increasingly common in cystic fibrosis (CF), but little exists describing its influence on mortality. Using national UK data, this study documents diabetes-specific mortality rates, estimates the impact of diabetes on survival, and estimates population attributable fractions. Methods: This retrospective cohort study identified 8,029 individuals aged 0-65 years from the UK CF Registry (1996-2005). 5,892 patients were included in analyses of mortality rates and 4,234 in analyses of risk factors. We calculated age-adjusted mortality rates using Poisson regression, standardized mortality ratios usin...
Source: Diabetes Care - November 16, 2009 Category: Endocrinology Authors: Chamnan P, Shine BS, Haworth CS, Bilton D, Adler AI Tags: Diabetes Care Source Type: journals

Predictors of oxygen desaturation during the six-minute walk test in patients with cystic fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Resting SpO2 < 96% and FEV1 < 40% can predict oxygen desaturation during the 6MWT. (Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - November 14, 2009 Category: Respiratory Medicine Source Type: journals

Association between nutritional status and dietary intake in patients with cystic fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The prevalence of malnutrition was low in this sample of patients. The study model demonstrated an association between dietary intake and nutritional status. Dietary intake was a predictive factor of statural growth in patients with cystic fibrosis. (Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - November 14, 2009 Category: Respiratory Medicine Source Type: journals

CF Worldwide meets Palestinian Minister of HealthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - November 14, 2009 Category: Respiratory Medicine Tags: Programs Source Type: organizations

Long-term gas exchange characteristics as marker of deterioration in patients with cystic fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the long-term course of blood gas measurements in relation to characteristics of lung function and the influence of different CFTR genotype upon this process. Methods: Serial annual measurements of PaO2 and PaCO2 assessed in relation to lung function, providing functional residual capacity (FRCpleth), lung clearance index (LCI), trapped gas (VTG), airway resistance (sReff), and forced expiratory indices (FEV1, FEF50), were collected in 164 children (83 males; 81 females) with CF over an age range of 5 to 18 years. Linear mixed model analysis and binary logistic regression analysis were used to define predominan...
Source: Respiratory Research - November 12, 2009 Category: Respiratory Medicine Authors: Richard KraemerPhilipp LatzinIsabelle PramanaPietro BallinariSabina GallatiUrs Frey Source Type: journals

Lung clearance index: Normal values, repeatability, and reproducibility in healthy children and adolescentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is increasing interest in using the Multiple Breath Washout technique and the lung clearance index (LCI) for detecting early pulmonary changes, for example, in cystic fibrosis lung disease. However, there are still limited data regarding equipment specific reference ranges, repeatability and reproducibility. The aim of this prospective study was to assess within-test repeatability, short term reproducibility and long term reproducibility, and to establish normal values for the LCI in healthy children and adolescents using the sidestream ultrasonic flow sensor (EasyOne Pro, MBW Module, ndd Medical Technologies, Switze...
Source: Pediatric Pulmonology - November 12, 2009 Category: Respiratory Medicine Authors: Susanne I. Fuchs, Johannes Eder, Helmut Ellemunter, Monika Gappa Source Type: journals

Long-term pulmonary outcome after meconium ileus in cystic fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To identify cystic fibrosis (CF) patients with a history of meconium ileus (MI) and to compare long-term outcome of these patients with CF patients without MI.370 CF patients who were treated at the Munich CF centre in 2006, mean age 17.1 years (range: 0-48), were classified with regard to a history of MI.Retrospective chart analysis regarding history of MI, age, and lung function and first detection of Pseudomonas aeruginosa as the primary outcome variables.We identified 60 patients with MI (16.2% of all patients with a mean age of 16.2 ± 9 years (0-41) who did not differ in age from patients without MI (17.3 ± 10; 0-48...
Source: Pediatric Pulmonology - November 12, 2009 Category: Respiratory Medicine Authors: Matthias Kappler, Maria Feilcke, Christian Schröter, Angelika Kraxner, Matthias Griese Source Type: journals

Texas to Start Cystic Fibrosis ScreeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Texas Department of State Health Services (DSHS) will add cystic fibrosis (CF) as part of the newborn screening panel in December. (Source: Blogged_Arteries)
Source: Blogged_Arteries - November 12, 2009 Category: Health Management Source Type: organizations

Early glucose abnormalities in cystic fibrosis are preceded by poor weight gain.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: BG(max) on OGTT >/= 8.2 mmol/L and CGM-time above 7.8mmol/l >/=4.5% are associated with declining wtSDS and lung-function in the preceding 12 months. PMID: 19910502 [PubMed - as supplied by publisher] (Source: Diabetes Care)
Source: Diabetes Care - November 12, 2009 Category: Endocrinology Authors: Hameed S, Morton JR, Jaffé A, Field PI, Belessis Y, Yoong T, Katz T, Verge CF Tags: Diabetes Care Source Type: journals

Growth in children with cystic fibrosis-related diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This is a retrospective case controlled study of growth and... (Source: PCCAS: Full newsfeed)
Source: PCCAS: Full newsfeed - November 11, 2009 Category: Practice Management Source Type: organizations

Growth in children with cystic fibrosis-related diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This is a retrospective case controlled study of growth and... (Source: Children's NSF Newsfeed)
Source: Children's NSF Newsfeed - November 11, 2009 Category: Child Development Source Type: organizations

CFW Newsletter Edition 12 online!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - November 10, 2009 Category: Respiratory Medicine Tags: Newsletter Source Type: organizations

Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A significant reduction in the number of bacteria was observed when initiating treatment 1 h post-infection compared with initiating treatment after 24 h, although the latest isolate avoided complete clearance. Early antibiotic treatment directed at the mucoid phenotype in mice also reduced the inflammation and, thereby, the lung tissue damage. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: van Gennip, M., Moser, C., Christensen, L. D., Bjarnsholt, T., Calum, H., Jensen, P. O., Christophersen, L., Hougen, H. P., Ciofu, O., Molin, S., Givskov, M., Hoiby, N. Tags: Original research Source Type: journals

Do specialized centers and specialists produce better outcomes for patients with chronic diseases than primary care generalists? A systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The available literature suggests that among patients with rheumatoid arthritis, diabetes mellitus or cystic fibrosis, outcomes are not superior in specialized centers or with subspecialists compared with other forms of chronic illness care. (Source: International Journal for Quality in Health Care)
Source: International Journal for Quality in Health Care - November 10, 2009 Category: Global & Universal Authors: Post, P. N., Wittenberg, J., Burgers, J. S. Tags: Papers Source Type: journals

Series of tests identifies cystic fibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Newborn screening is just the first step in identifying cystic fibrosis. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - November 10, 2009 Category: Consumer Health News Source Type: news

Singing helpsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
'Fronting a band is good for my cystic fibrosis' (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 9, 2009 Category: Consumer Health News Tags: Health Source Type: news

Physiotherapy and pregnancy in cystic fibrosis by Brenda ButtonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Physiotherapy in the planning stage, during pregnancy and the post-natal period in cystic fibrosis (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - November 7, 2009 Category: Respiratory Medicine Tags: Newsletter Source Type: organizations

DELTAF508/5T-13TG MUTATIONS by Bob WilliamsonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - November 7, 2009 Category: Respiratory Medicine Tags: Newsletter Source Type: organizations

Pseudomonas aeruginosa Population Biology in Chronic Obstructive Pulmonary DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Intraclonal microevolution and the frequent turnover or loss of clones are typical for infections with P. aeruginosa in COPD. This epidemiological signature differs from that of the chronic carriage of the same P. aeruginosa clone in patients with cystic fibrosis. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 6, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

Inspire Completes Patient Enrollment In Three Late-Stage Clinical Trials In Cystic Fibrosis, Dry Eye And BlepharitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inspire Pharmaceuticals, Inc. (NASDAQ: ISPH) announced today patient enrollment is complete in three of its late-stage clinical trials. "We are pleased to be executing on our strategic plan with the achievement of these patient enrollment milestones in the clinical development programs for denufosol, PROLACRIA™ and AZASITE®, as this places us in a position to have top-line results from all our late-stage clinical programs within 18 months. (Source: Eye Health / Optometry News From Medical News Today)
Source: Eye Health / Optometry News From Medical News Today - November 6, 2009 Category: Opthalmology Tags: cystic fibrosis Source Type: news

Growth in children with cystic fibrosis-related diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study highlights the compromise in height velocity and lung function that occurs prior to diagnosis of CFRD in children with CF, and a reduction in height velocity should be considered an indicator of impaired glucose metabolism. It would be useful to know whether early treatment with insulin can help promote catch up growth. Pediatr Pulmonol. © 2009 Wiley-Liss, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - November 6, 2009 Category: Respiratory Medicine Authors: M.S. Cheung, N.A. Bridges, S.A. Prasad, J. Francis, S.B. Carr, R. Suri, I.M. Balfour-Lynn Source Type: journals