Cystic Fibrosis
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Infant With Fat-Soluble Vitamin Deficiencies Caused by Cystic Fibrosis
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A 3-month-old African American boy was referred for evaluation of poor weight gain and vomiting. The infant had been evaluated by his primary care physician 15 times within the past 6 weeks; he had no change in symptoms despite various treatments. (Source: Consultant Live)
Source: Consultant Live - February 9, 2010 Category: Primary Care Source Type: info
(French) Mucoviscidose et fertilité
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Translated by Marie-Claude Falardeau (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 9, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
(French) Le groupe international de physiothérapie Mucoviscidose
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Translated by Florence Stubbs (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 9, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
(French) Breathing for a Living (Respirer pour vivre)
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Translated by Corinne Boyens (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 9, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
(French) Ouverture de la clinique de traitement de la mucoviscidose : Tbilisi, Géorgie
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Translated by Corinne Boyens (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 9, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
(French) La détection de la délétion complète maintenant possible pour la mucoviscidose avec le Ambr
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Translated by Marie-Claude Falardeau (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 9, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
The experience of parenting children with chronic health conditions: a new reality
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Conclusion. This metasynthesis provides an enhanced empirical understanding of the experiences of people who parent and care for children with chronic health conditions as described by the reviewed literature. While it is apparent that many of these experiences are perceived as negative and undesirable, parents are also noted to describe positive experiences which enhance their lives and give them meaning.Relevance to clinical practice. This metasynthesis provides healthcare professionals with information pertaining to the lived experiences of the parents of children with chronic health conditions. It highlights areas requ...
Source: Journal of Nursing and Healthcare of Chronic Illness - February 9, 2010 Category: Nursing Authors: Elizabeth Kepreotes, Diana Keatinge, Teresa Stone Tags: ARTICLES Source Type: journals
Adapting to clogged airways makes common pathogen resist powerful antibiotics -- even without previous exposure
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Certain bacteria cause chronic lung infections in people with cystic fibrosis. Surviving in this oxygen-poor, nitrate-rich environment makes the bacteria less susceptible to antibiotics. (Source: uwnews.org | Health and Medicine)
Source: uwnews.org | Health and Medicine - February 8, 2010 Category: Universities & Medical Training Tags: Health and Medicine Source Type: news
Cystic Fibrosis Foundation Receives $521,000 From BJ's Restaurants, Inc., As Part Of Long-Term Commitment To Fight Life-Threatening Disease
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As part of a steadfast commitment to finding a cure for cystic fibrosis, BJ's Restaurants, Inc. donated $521,000 to the Cystic Fibrosis Foundation in 2009 for research, care and education programs. BJ's has been involved with the Foundation since 1998 and is one of its largest and most loyal corporate supporters. "We are truly grateful to BJ's restaurants, their team members and their customers for their generosity and desire to help support the Cystic Fibrosis Foundation's mission," said C... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 8, 2010 Category: Consumer Health News Tags: cystic fibrosis Source Type: news
Cystic Fibrosis Foundation Receives $521,000 From BJ's Restaurants, Inc., As Part Of Long-Term Commitment To Fight Life-Threatening Disease
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As part of a steadfast commitment to finding a cure for cystic fibrosis, BJ's Restaurants, Inc. donated $521,000 to the Cystic Fibrosis Foundation in 2009 for research, care and education programs. BJ's has been involved with the Foundation since 1998 and is one of its largest and most loyal corporate supporters... (Source: Cystic Fibrosis News From Medical News Today)
Source: Cystic Fibrosis News From Medical News Today - February 8, 2010 Category: Respiratory Medicine Tags: cystic fibrosis Source Type: news
Gene test that screens 109 diseases to be offered online
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The saliva test identifies if a prospective parent is carrying genetic mutations that could cause life-threatening illnesses, like cystic fibrosis or spinal muscular atrophy. (Source: the Mail online | Health)
Source: the Mail online | Health - February 8, 2010 Category: Consumer Health News Source Type: news
What is the Differential Diagnosis of Failure to Thrive?
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Discussion
Failure to Thrive (FTT) is defined as persistent weight below the 3rd percentile for age in infants and young children. The associated terms “Failure to gain weight” (FGW) or “Lack of Normal Physiologic Growth and Development” are more precise, especially for children who are not below the 3rd percentile but are losing weight over time and/or crossing percentile lines on their growth curve. For general growth parameters see How Do I Calculate Mid-Parental Height and Other Growth Parameters? About 70-80% of FTT cases have psychosocial problems that are associated with the FTT or the primar...
Source: PediatricEducation.org - February 8, 2010 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: info
Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis
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Conclusions: The low prevalence of carbohydrate intolerance in this population is probably a result of their young age. Another possibility is the low frequency of the [Delta]F508 mutation. Although not conclusive, these data suggest that in addition to age, the genotype:phenotype ratio may influence the development of glucose intolerance in patients with CF. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - February 8, 2010 Category: Endocrinology Authors: Crésio Alves, Daniela S Lima, Mauricio Cardeal, Angelica Santana Source Type: journals
Pseudomonas aeruginosa Cystic Fibrosis isolates of similar RAPD genotype exhibit diversity in biofilm forming ability in vitro.
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Conclusions:
Clinical isolates that do not produce biofilms in the laboratory must have the ability to survive in the patient lung. We propose that a synergy exists between isolates in vivo, which allows "non biofilm-forming" isolates to be incorporated into the biofilm. Therefore, there is the potential for strains that are apparently non-biofilm forming in vitro to participate in biofilm-mediated pathogenesis in the CF lung. (Source: BioMed Central)
Source: BioMed Central - February 8, 2010 Category: Journals (General) Authors: Elena DeligianniSally PattisonDaniel BerrarNigel TernanRichard HaylockJohn MooreJ. Stuart ElbornJames Dooley Source Type: journals
CREON(R) (pancrelipase) Delayed-Release Capsules Significantly Improves Fat Absorption In Children With Cystic Fibrosis
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Solvay Pharmaceuticals, Inc. announced that Phase IIIb data published in the January issue of Clinical Therapeutics confirm that CREON® (pancrelipase) Delayed-Release Capsules significantly improves a key measure of fat absorption in children aged 7-11 years who have exocrine pancreatic insufficiency (EPI) due to cystic fibrosis (CF), EPI is a condition resulting from a deficiency in the production and/or secretion of pancreatic enzymes that are necessary to digest nutrients in food... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 6, 2010 Category: Consumer Health News Tags: cystic fibrosis Source Type: news
CREON(R) (pancrelipase) Delayed-Release Capsules Significantly Improves Fat Absorption In Children With Cystic Fibrosis
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Solvay Pharmaceuticals, Inc... (Source: Endocrinology News From Medical News Today)
Source: Endocrinology News From Medical News Today - February 6, 2010 Category: Endocrinology Tags: cystic fibrosis Source Type: news
Dietary Supplementation with Pressurized Whey in Patients with Cystic Fibrosis
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Journal of Medicinal Food Feb 2010, Vol. 13, No. 1: 77-82. (Source: Journal of Medicinal Food)
Source: Journal of Medicinal Food - February 6, 2010 Category: Nutrition Tags: article Source Type: journals
CREON (Pancrelipase) Delayed-Release Capsules Significantly Improves Fat Absorption in Children with Cystic Fibrosis, Study in Clinical Therapeutics Reports
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Data CONFIRMS safe and effective use of CREON® in pediATRIC
PAtients -
MARIETTA, Ga., Feb. 5 /PRNewswire-FirstCall/ -- Solvay
Pharmaceuticals, Inc. announced today that Phase IIIb data
published in the January issue of Clinical Therapeutics... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - February 5, 2010 Category: Pharmaceuticals Source Type: clinical trials
(French) LA VIE EST UN DEFI
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Translated by Patricia PORTETELLE (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
(French) Le dialogue entre le cerveau et le corps
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Translated by Florence Maag (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
(French) La mucoviscidose en Belgique
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Translated by Marie Claire Britton (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
(French) PERSPECTIVES DE NOUVELLES THERAPIES DE LA MUCOVISCIDOSE
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Translated by Benoit TCHUNDJU (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
Transforming Growth Factor {beta}1 Inhibits Cystic Fibrosis Transmembrane Conductance Regulator-dependent cAMP-stimulated Alveolar Epithelial Fluid Transport via a Phosphatidylinositol 3-Kinase-dependent Mechanism [Cell Biology]
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Exogenous or endogenous β2-adrenergic receptor agonists enhance alveolar epithelial fluid transport via a cAMP-dependent mechanism that protects the lungs from alveolar flooding in acute lung injury. However, impaired alveolar fluid clearance is present in most of the patients with acute lung injury and is associated with increased mortality, although the mechanisms responsible for this inhibition of the alveolar epithelial fluid transport are not completely understood. Here, we found that transforming growth factor β1 (TGF-β1), a critical mediator of acute lung injury, inhibits β2-adrenergic receptor a...
Source: Journal of Biological Chemistry - February 5, 2010 Category: Chemistry Authors: Roux, J., Carles, M., Koh, H., Goolaerts, A., Ganter, M. T., Chesebro, B. B., Howard, M., Houseman, B. T., Finkbeiner, W., Shokat, K. M., Paquet, A. C., Matthay, M. A., Pittet, J.-F. Tags: Cell Biology Source Type: journals
(Dutch) Het leven is juist een uitdaging
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Translated by René Knoop (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
(Dutch) CF in België
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Translated by Henny de Lege (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
(Dutch) Breathing for a Living
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Translated by Mariëtte van Drunen (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
(Dutch) De Internationale Fysiotherapie Groep Cystic Fibrosis
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Translated by Margit Brave (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
Current Clinical Prospects for Gene and Stem Cell Therapies to treat Cystic Fibrosis and other Genet
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By Dace Shugg, Bob Williamson (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
The Survival of the (Un)Fittest
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By Dick Lijnsveld (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
The International Physiotherapy Group Cystic Fibrosis
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By Brenda Button (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
Cystic fibrosis patients having Children
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(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
Air Travel and Lung Disease: Current Guidelines Are Inappropriate
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(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
Corus Pharma's Phase III Trial for Cystic Fibrosis Drug
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(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
Making Music that Makes a Difference
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(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
Gross Deletion Detection Now Available with the Ambry Test for Cystic Fibrosis
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(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 5, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
Transient elastography in patients with cystic fibrosis
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Conclusion Considering the limitations of US and the low risk-benefit rate of liver biopsy in most CF patients, this preliminary study
suggests that TE is an attractive non-invasive way to assess and follow-up liver disease in these patients.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00247-009-1531-zAuthors
Renaud Menten, Cliniques Universitaires St Luc Radiology Avenue Hippocrate 10 Brussels 1200 BelgiumAnissa Leonard, Cliniques Universitaires St Luc Pediatrics Brussels BelgiumPhilippe Clapuyt, Cliniques Universitaires St Luc Radiology Avenue Hippocrate 10 Brussels 1200 Belgium...
Source: Pediatric Radiology - February 5, 2010 Category: Radiology Tags: Pediatric Radiology Source Type: journals
[Editorial] Fabricated or induced illness by carers: a complex conundrum
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You are asked to pay a house visit to a young boy whose medical history includes cerebral palsy, cystic fibrosis, diabetes, food allergies, and intolerance to sunlight. However, on examination, you can find nothing wrong with him. On returning to the surgery, you follow-up with the numerous consultants at the various hospitals where the boy attends. They are also baffled. The only common feature is the mother's insistence that the boy is very ill. In this tragic but true case of child maltreatment, which received wide publicity in the UK recently, doctors involved in the boy's management concluded that there was little wro...
Source: LANCET - February 5, 2010 Category: Journals (General) Authors: The Lancet Tags: Editorial Source Type: journals
Transcriptional response of Burkholderia cenocepacia J2315 sessile cells to treatments with high doses of hydrogen peroxide and sodium hypochlorite
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Conclusion:
These observations have highlighted that sessile B. cenocepacia J2315 cells may alter several pathways in response to exposure to ROS and they have led to the identification of many genes not previously implicated in the stress response of this pathogen. (Source: BMC Genomics - Latest articles)
Source: BMC Genomics - Latest articles - February 5, 2010 Category: Genetics & Stem Cells Authors: Elke PeetersAndrea SassEshwar MahenthiralingamHans NelisTom Coenye Source Type: journals
Feasibility study to inform the design of a randomised controlled trial to eradicate Pseudomonas aeruginosa infection in individuals with Cystic Fibrosis
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Conclusions:
This work demonstrates the importance of feasibility studies in preparation for multicentre clinical trials. It confirmed the uncertainty amongst clinicians and patients about the clinical question, enabled assessment of the number of potentially eligible patients, the proportion of patients and clinicians prepared to participate and aspects of trial design which might encourage this. It showed that a clinical trial was feasible, but only if patients were recruited from across United Kingdom. (Source: Trials)
Source: Trials - February 5, 2010 Category: Journals (General) Authors: Helen HickeyAshley JonesWarren LenneyPaula WilliamsonRosalind Smyth Source Type: journals
"All at Sea": The Experience of Living With Cystic Fibrosis
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In this qualitative study the researchers explored living with cystic fibrosis (CF)—a chronic, life-threatening, life-limiting disease that demands a relentless regime of daily treatment. The unique challenges and issue for care that CF presents were considered. Utilizing a phenomenological perspective, data drawn from unstructured interviews included narratives and drawings contributed by children, adolescents, young adults, and parents—eight families representing nine young people with CF. In line with van Manen’s approach, four existentials were used to consider a lifeworld in which notions of time, bo...
Source: Qualitative Health Research - February 4, 2010 Category: Global & Universal Authors: Jessup, M., Parkinson, C. Tags: Articles Source Type: journals
MRP transporters as membrane machinery in the bradykinin-inducible export of ATP
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Abstract Adenosine triphosphate (ATP) plays the role of an autocrine/paracrine signal molecule in a variety of cells. So far, however,
the membrane machinery in the export of intracellular ATP remains poorly understood. Activation of B2-receptor with bradykinin-induced
massive release of ATP from cultured taenia coli smooth muscle cells. The evoked release of ATP was unaffected by gap junction
hemichannel blockers, such as 18α-glycyrrhetinic acid and Gap 26. Furthermore, the cystic fibrosis transmembrane regulator
(CFTR) coupled Cl− channel blockers, CFTR(inh)172, 5-nitro-2-(3-phenylpropylamino)-benzoic a...
Source: Naunyn-Schmiedeberg's Archives of Pharmacology - February 4, 2010 Category: Drugs & Pharmacology Tags: Naunyn-Schmiedeberg's Archives of Pharmacology Source Type: journals
Life is Meant to be a Challenge
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By Peter Oxford (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 4, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
The Dialog Between the Brain and the Body
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By Ester Fride (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 4, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
CF in Belgium
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By Karleen De Rijcke (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 4, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
Towards new Therapies for Cystic Fibrosis
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By Alan S. Verkman (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 4, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
Opening of the CF Clinic: Tbilisi, Georgia
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(Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 4, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
Breathing for a Living
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By Dawn Stevens McGuinness (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 4, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
Empyema due to a highly transmissible Pseudomonas aeruginosa strain in an adult cystic fibrosis patient.
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We describe the first case of pleural empyema due to a particularly pathogenic transmissible strain of P. aeruginosa (the Liverpool epidemic strain [LES]) in an adult CF patient.
PMID: 20133415 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - February 4, 2010 Category: Microbiology Authors: Mohan K, Lakshman V, Fothergill J, Ledson M, Winstanley C, Walshaw M Tags: J Med Microbiol Source Type: journals
Vertex Announces Results from Phase 2a Trial of VX-809 Targeting the Defective Protein Responsible for Cystic Fibrosis
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-VX-809 was well-tolerated at all dose levels when dosed once
daily for 28 days-
-Statistically significant changes observed in measurement of
sweat chloride suggest increased CFTR activity-
-Data support planned combination trial of VX-809 and... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - February 3, 2010 Category: Pharmaceuticals Source Type: clinical trials
(Spanish) EL CORREO
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Translated by Martha Rodríguez (Source: Cystic Fibrosis Worldwide)
Source: Cystic Fibrosis Worldwide - February 3, 2010 Category: Respiratory Medicine Tags: CFW Newsletter Source Type: organizations
