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1141 records returned

Long-Term, Post-Deep Brain Stimulation Management of a Series of 36 Patients Affected With Refractory Gilles de la Tourette SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Gilles de la Tourette syndrome is a complex neuropsychiatric disorder with a significant prevalence in the general population. More than 50% of the patients with TS present a behavioral comorbidity, and anxiety and depression are, to various degrees, associated to this "waxing and waning" clinical picture. DBS in our experience proved to be a valid treatment modality for those patients who fail to respond to conservative treatment modalities. A multidisciplinary team is nevertheless necessary to properly handle this complex therapeutic option. (Source: Neuromodulation)
Source: Neuromodulation - November 20, 2009 Category: Neurology Authors: Domenico Servello, Marco Sassi, Arianna Brambilla, Stefano Defendi, Mauro Porta Source Type: journals

Stimulation-Induced Dyskinesia in the Early Stage after Subthalamic Deep Brain StimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stereotact Funct Neurosurg 2010;88:29-34 (DOI:10.1159/000260077) (Source: Karger Publishers)
Source: Karger Publishers - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Construction of Relational Topographies from the Quantitative Measurements of Functional Deep Brain Stimulation Using a 'Roving Window' Interpolation AlgorithmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stereotact Funct Neurosurg 2010;88:16-23 (DOI:10.1159/000260075) (Source: Karger Publishers)
Source: Karger Publishers - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Successful Treatment of Chronic Resistant Alcoholism by Deep Brain Stimulation of Nucleus Accumbens: First Experience with Three CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pharmacopsychiatry 2009; 42: 288-291DOI: 10.1055/s-0029-1233489© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 19, 2009 Category: Psychiatry Tags: Letter Source Type: journals

Transient gender-related effects in Parkinson’s disease patients with subthalamic stimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Little is known about the gender-related long-term efficacy and safety after subthalamic nucleus deep brain stimulation (STN DBS) implant for Parkinson’s disease (PD), although some differences could be expected as recently stated in a short-term report. We assessed the possible gender-related differences in clinical outcome and disease progression along a 5-year period after STN DBS for PD. A prospective cohort of PD patients who underwent STN DBS and reached the 5-year follow-up (FU) was considered. Clinical outcome, disease progression and side effects were assessed at baseline and 1, 3, and 5&...
Source: Journal of Neurology - November 17, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals

Dravet syndrome and deep brain stimulation: Seizure control after 10 years of treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dravet syndrome is a genetically determined severe epilepsy associated with cognitive decline and ataxia. The many types of seizures seen in these patients are typically pharmacoresistant. Here we describe two adults with Dravet syndrome who were treated with thalamic deep brain stimulation (DBS) and followed for 10 years. One patient with partial onset seizures received DBS at age 19 and showed a marked improvement in seizure control after DBS insertion and stimulation. The other patient with generalized onset seizures received DBS at age 34 and did not show any immediate benefit. No side effects or changes in cognition w...
Source: Epilepsia - November 17, 2009 Category: Neurology Authors: Danielle M. Andrade, Clement Hamani, Andres M. Lozano, Richard A. Wennberg Source Type: journals

Automated Optimization of Subcortical Cerebral MR Imaging-Atlas Coregistration for Improved Postoperative Electrode Localization in Deep Brain Stimulation [BRAIN]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The present method improves the registration accuracy of postoperative structural MR imaging data into MNI space within the basal ganglia, allowing automated normalization with increased precision at stereotactic targets, and enables lead-contact localization in MNI coordinates for quantitative group analysis. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - November 13, 2009 Category: Radiology Authors: Schonecker, T., Kupsch, A., Kuhn, A.A., Schneider, G.-H., Hoffmann, K.-T. Tags: brain Source Type: journals

Subthalamic Nucleus Deep Brain Stimulation Improves Saccades in Parkinson's DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These results demonstrate that STN DBS has differential effects on the parameters of visually guided and internally generated saccades. These effects may be mediated by the influence of STN DBS on cortical ocular motor areas, the basal ganglia, ocular motor loop, or downstream structures such as the brainstem saccade generating circuits. (Source: Neuromodulation)
Source: Neuromodulation - November 13, 2009 Category: Neurology Authors: Adrian P. Fawcett, Esther G. González, Elena Moro, Martin J. Steinbach, Andres M. Lozano, William D. Hutchison Source Type: journals

Hypomania with hypersexuality following bilateral anterior limb stimulation in obsessive-compulsive disorder.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This 28-year-old Chinese man was referred for deep brain stimulation (DBS) evaluation for an 8-year history of refractory obsessive-compulsive disorder. After the patient had signed an informed consent, the authors implanted DBS leads. Hypomania with hypersexuality was noted on stimulation at Contact 2 and became aggravated with a higher voltage (>/=3 V) during chronic bilateral DBS. After the voltage was decreased to 1 V, the patient's hypomanic symptoms subsided and his libido returned to baseline. PMID: 19911886 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 13, 2009 Category: Neurosurgery Authors: Chang CH, Chen SY, Hsiao YL, Tsai ST, Tsai HC Tags: J Neurosurg Source Type: journals

Long-term results of thalamic deep brain stimulation for essential tremor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Deep brain stimulation of the VIM is an efficient and safe treatment for ET. Tremor and handwriting improvements in long-term follow-up are stable. The patients' perception of their outcome is quite good. However, tolerance may develop in some patients requiring changes in stimulation parameters. PMID: 19911883 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 13, 2009 Category: Neurosurgery Authors: Zhang K, Bhatia S, Oh MY, Cohen D, Angle C, Whiting D Tags: J Neurosurg Source Type: journals

Interruption of deep brain stimulation of the globus pallidus in primary generalized dystoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study describes the course of dystonia during a 48 hours period without stimulation followed by a 24 hours period after turning ON the stimulator. 14 patients with generalized dystonia treated with bilateral GP DBS for 3 years or more were recruited. Blinded video-based analysis was performed using Burke-Fahn-Marsden scale at (1) baseline (ON stimulation), (2) up to 48 hours after the stimulator was turned OFF, and (3) 24 hours after the stimulator was turned ON. 13 patients completed the 48 hours OFF-stimulation period. The dystonia movement score progressively worsened from 24.3 ± 13.9 at baseline to 48.9 ± 19.8 a...
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: David Grabli, Claire Ewenczyk, Maria-Clara Coelho-Braga, Christelle Lagrange, Valerie Fraix, Philippe Cornu, Alim-Louis Benabid, Marie Vidailhet, Pierre Pollak Source Type: journals

[In Context] Lifeline: Maria C Rodriguez-OrozEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Maria C Rodriguez-Oroz received her MD degree from the University of Navarra, Spain, where she completed her neurology residency. She did a fellowship in movement disorders and obtained a PhD studying the physiology of the subthalamic nucleus in Parkinson's disease. She is a consultant neurologist and associate professor of neurology at the Clinic and University of Navarra. Currently, she is jointly responsible for the deep brain stimulation programme and leads research in dementia and other non-motor aspects of Parkinson's disease. (Source: Lancet Neurology)
Source: Lancet Neurology - November 9, 2009 Category: Neurology Authors: The Lancet Neurology Tags: In Context Source Type: journals

Stereotactic Radiosurgery Reduces Tremor, Complications in Parkinson's and Essential TremorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from a long-term cohort study in patients with medically refractory PD and ET suggest that stereotactic radiosurgery provided outcomes comparable to deep brain stimulation and radiofrequency. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 6, 2009 Category: Consumer Health News Tags: Neurology & Neurosurgery Source Type: news

Thalamic stimulation in multiple sclerosis: evidence for a 'demyelinative thalamotomy'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The mechanism of action of deep brain stimulation (DBS) in the alleviation of tremor in multiple sclerosis (MS) and other neurological disorders is unknown. Moreover, whether the trauma accompanying this surgery is responsible for the induction of new MS plaques is controversial. Here we report the first description of the post-mortem imaging and pathologic findings in the brain of a MS patient who underwent thalamic DBS for the treatment of MS-induced tremor. MR imaging of formalin-fixed brain slices was carried out at 1.5, 3 and 7 Tesla and correlated with the histopathology. There were numerous demyelinative plaques in ...
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Moore, G. W., Vitali, A. M, Leung, E., Laule, C., Kozlowski, P., MacKay, A. L, Honey, C. R Tags: Articles Source Type: journals

Hypothalamic stimulation for trigeminal neuralgia in multiple sclerosis patients: efficacy on the paroxysmal ophthalmic painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, deep brain stimulation may be considered as an adjunctive procedure for treating refractory paroxysmal pain within the first trigeminal division so as to avoid the complication of corneal reflex impairment that is known to follow ablative procedures. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 6, 2009 Category: Neurology Authors: Cordella, R., Franzini, A., La Mantia, L., Marras, C., Erbetta, A., Broggi, G. Tags: Articles Source Type: journals

Effect of subthalamic deep brain stimulation on postural abnormality in Parkinson disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Postural abnormality in patients with PD could be ameliorated by STN DBS, and therefore surgery should be considered before irreversible spinal deformity develops. PMID: 19895200 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 6, 2009 Category: Neurosurgery Authors: Umemura A, Oka Y, Ohkita K, Yamawaki T, Yamada K Tags: J Neurosurg Source Type: journals

Gamma Knife thalamotomy for treatment of essential tremor: long-term results.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A VIM thalamotomy with the Leksell GK offers a safe and effective alternative for surgical treatment of ET. It is particularly applicable to patients who are not ideal candidates for deep brain stimulation but can be offered to all patients who are considering surgical intervention for ET. PMID: 19895197 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 6, 2009 Category: Neurosurgery Authors: Young RF, Li F, Vermeulen S, Meier R Tags: J Neurosurg Source Type: journals

Tuning Depression Circuits Using Deep Brain StimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.Air date: 2/17/2010 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 5, 2009 Category: Journals (General) Tags: Upcoming Events Source Type: events

A family with a hereditary form of torsion dystonia from Northern Sweden treated with bilateral pallidal deep brain stimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the results of pallidal DBS in a family with non-DYT1 dystonia where DYT5 to 17 was excluded. The dystonia is following an autosomal dominant pattern. Ten members had definite dystonia and five had dystonia with minor symptoms. Four patients received bilateral pallidal DBS. Mean age was 47 years. The patients were evaluated before surgery, and "on" stimulation after a mean of 2.5 years (range 1-3) using the Burke-Fahn-Marsden scale (BFM). Mean BFM score decreased by 79 % on stimulation, from 42.5 ± 24 to 9 ± 6.5 at the last evaluation. Cervical involvement improved by 89%. The 2 patients with oromandibular dys...
Source: Movement Disorders - November 4, 2009 Category: Neurology Authors: Patric Blomstedt, Marwan I. Hariz, Stephen Tisch, Monica Holmberg, Tommy A. Bergenheim, Lars Forsgren Source Type: journals

Deep Brain Stimulation Gives Hope For Very Severe DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thanks to a new method, there is a reason for hope for patients with very severe depression. Physicians in Germany have treated ten patients with deep brain stimulation. Subsequent to this treatment, the patients' depression improved significantly in half of the patients. All patients had suffered from very severe depression for many years and did not respond to any other therapies. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 3, 2009 Category: Science Source Type: news

New Therapy Gives Hope For Very Severe DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thanks to a new method there is a reason for hope for patients with very severe depression. Physicians at the University Clinics of Bonn and Cologne have treated ten patients with deep brain stimulation. This involved implanting electrodes in the patients' nucleus accumbens. This centre has a key role as the brains reward system, whose function may be impaired in depressive people. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 3, 2009 Category: Consumer Health News Tags: Depression Source Type: news

Less Invasive Stereotactic Radiosurgery As Effective In Eliminating Parkinson's Disease Tremors As Other TreatmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stereotactic radiosurgery (SRS) offers a less invasive way to eliminate tremors caused by Parkinson's disease and essential tremor than deep brain stimulation (DBS) and radiofrequency (RF) treatments, and is as effective, according to a long-term study presented November 2, 2009, at the 51st Annual Meeting of the American Society for Radiation Oncology (ASTRO). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 3, 2009 Category: Consumer Health News Tags: parkinson's Disease Source Type: news

New therapy gives hope for very severe depressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(University of Bonn) Thanks to a new method there is a reason for hope for patients with very severe depression. Physicians at the University Clinics of Bonn and Cologne have treated ten patients with deep brain stimulation. Subsequent to this treatment, the patients' depression improved significantly in half of the patients. All patients had suffered from very severe depression for many years and did not respond to any other therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 2, 2009 Category: Global & Universal Source Type: news

Stereotactic radiosurgery as effective in eliminating Parkinson's disease tremors as other treatments but less invasiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(American Society for Radiation Oncology) Stereotactic radiosurgery (SRS) offers a less invasive way to eliminate tremors caused by Parkinson's disease and essential tremor than deep brain stimulation (DBS) and radiofrequency (RF) treatments, and is as effective, according to a long-term study presented Nov. 2, 2009, at the 51st Annual Meeting of the American Society for Radiation Oncology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 2, 2009 Category: Cancer & Oncology Source Type: news

Beyond “Poke & Hope”: The next steps for DBS for psychiatric disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effort to apply Deep Brain Stimulation (DBS) in the realm of psychiatric disease is the most prominent frontier in functional neurosurgery today. A vast patient population with an unmet need certainly is the main factor in driving these efforts. However, it is the unique nature of the technique of DBS that is allowing these efforts to move forward despite the nefarious past of neurological surgery for psychiatric disorders has. DBS, with its inherently reversible nature allows a degree of safety that stereotactic lesions do not possess. Furthermore, the ability to program DBS systems in situ allows a degree of freedom ...
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Brian Harris Kopell, Jerry Halverson Tags: Editorials Source Type: journals

Functional topography of the ventral striatum and anterior limb of the internal capsule determined by electrical stimulation of awake patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Acute behavioral and subjective responses can be consistently obtained from stimulation in the ventral ALIC and VS region. Positive changes in mood and anxiety were reproducibly elicited in the ventral ALIC area.Significance: Intraoperative awake stimulation and postoperative programming of patients undergoing DBS for MDD provide unique opportunities to explore the subjective responses and behavioral phenomena related to electrical stimulation of the area spanning from the dorsal ALIC to the ventral striatum. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Andre Machado, Suzanne Haber, Nathaniel Sears, Benjamin Greenberg, Donald Malone, Ali Rezai Tags: Original Research Articles Source Type: journals

Analysis of the Mechanism of Action of Deep Brain Stimulation Using the Concepts of Dither Injection and the Equivalent NonlinearityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deep brain stimulation (DBS) is a widely applied clinical procedure for the alleviation of pathological neural activity, and is particularly effective in suppressing the symptoms of Parkinson's disease. The mechanisms of action of DBS remain to be fully elucidated. In this paper, we present an application to DBS of the concepts of dither injection and equivalent nonlinearity from the theory of nonlinear feedback control systems. We propose that this model provides a framework for understanding the mechanism by which an injected high-frequency signal can quench undesired oscillations in closed-loop systems of interacting ne...
Source: IEEE Transactions on Biomedical Engineering - October 30, 2009 Category: Biomedical Engineering Source Type: journals

Deep Brain Stimulation Reduces Tic Severity in Intractable Tourette SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from a new study show that Tourette patients undergoing DBS had reductions in tic severity and improvement in neuropsychiatric symptoms without a negative effect on cognitive function. Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - October 30, 2009 Category: Psychiatry Tags: Neurology & Neurosurgery Source Type: info

[Deep brain stimulation: 12 years' experience and 150 patients treated with a follow-up of over a year.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS. DBS is a suitable technique for the treatment of movement disorders. The neuronal activity of the sub-thalamus and the internal globus pallidus presents its own characteristics that reflect the motor symptoms of the patients. Surface electromyography proves to be useful for quantifying the patients' improvement. PMID: 19859873 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - October 29, 2009 Category: Neurology Authors: Figueiras-Mendez R, Magarinos-Ascone C, Regidor I, Del Alamo-De Pedro M, Cabanes-Martinez L, Gomez-Galan M Tags: Rev Neurol Source Type: journals

Deep brain stimulation as a new therapeutic approach in therapy-resistant mental disorders: ethical aspects of investigational treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Deep brain stimulation (DBS) is an established treatment option for some movement disorders, in particular Parkinson’s disease. Only recently, a number of promising studies with small samples of patients have been published in which impressive therapeutic outcomes achieved by DBS in otherwise treatment-resistant obsessive–compulsive disorder, major depression, and Tourette’s syndrome were reported. It seems probable that the investigational approach to treat mental disorders by DBS will increase substantially. Neurosurgical interventions in psychiatric patients raise ethical considerations not...
Source: European Archives of Psychiatry and Clinical Neuroscience - October 29, 2009 Category: Neuroscience Tags: European Archives of Psychiatry and Clinical Neuroscience Source Type: journals

Cutaneous Herpes Zoster and Implantable Pulse GeneratorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. He had excellent recovery of HZ lesions and related pain after specific antiviral therapy. The importance of a correct diagnosis of this unusual complication is outlined in order to minimize the risk of debilitating chronic HZ-associated pain. (Source: Neuromodulation)
Source: Neuromodulation - October 29, 2009 Category: Neurology Authors: Luigi Michele Romito, Alberto Albanese Source Type: journals

Thoracolumbar spinal fixation for camptocormia in Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A man with early non-fluctuating Parkinson’s disease developed disabling camptocormia. The patient was treated with posterior thoracolumbar fixation, which subsequently had to be augmented with anterior interbody fusion. Although the patient ultimately achieved excellent sagittal correction, his postoperative course was complicated and prolonged. Therefore, although this case demonstrates that spinal fixation surgery can be successful, it should probably only be offered after subthalamic nucleus deep brain stimulation has been unsuccessful, or for well motivated patients who express a strong wish for this major recon...
Source: Journal of Neurology, Neurosurgery & Psychiatry - October 28, 2009 Category: Neurosurgery Authors: Peek, A C, Quinn, N, Casey, A T H, Etherington, G Tags: Short reports Source Type: journals

Deep Brain Stimulation May Be Effective Treatment For Tourette's SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deep brain stimulation may be a safe and effective treatment for Tourette's syndrome, according to new research. The first symptoms of Tourette syndrome are almost always noticed in childhood and some common tics include eye blinking, facial grimacing, shoulder shrugging and head or shoulder jerking. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 28, 2009 Category: Science Source Type: news

Thalamo-cortical processing of near-threshold somatosensory stimuli in humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Somatosensory stimuli elicit complex cortical responses that are discernible as somatosensory evoked potentials (SEPs) in scalp electroencephalographic recordings. Whereas earlier SEP components, occurring up to 100 ms after stimulus delivery, have been labeled 'preconscious', later responses have been associated with stimulus awareness. To date, how far these processes are primarily cortical or comprise additional subcortical operations remains open. Therefore, we recorded thalamic and scalp SEPs evoked by perceived as well as unperceived median nerve stimulation in neurosurgical patients with electrodes implanted into th...
Source: European Journal of Neuroscience - October 28, 2009 Category: Neuroscience Authors: Fabian Klostermann, Michael Wahl, Jesko Schomann, Andreas Kupsch, Gabriel Curio, Frank Marzinzik Source Type: journals

For Tourette Syndrome, Implanted Device May HelpEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deep brain stimulation reduced tics in small study Source: HealthDay Related MedlinePlus Topic: Tourette Syndrome (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - October 27, 2009 Category: Consumer Health News Source Type: consumer

Weight changes associated with unilateral STN DBS and advanced PDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Weight gain following bilateral subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson disease (PD) has been characterized previously, but little is known about changes in weight following unilateral STN DBS. Weight gain of approximately 10kg at one year after bilateral STN DBS for PD has been noted in previous studies, and PD in the absence of DBS has been associated with weight loss. A case-control comparison evaluated the change in weight following unilateral STN DBS in PD. In 39 patients who underwent unilateral STN DBS for PD, we measured the weight change over 1 year versus both preoperative weig...
Source: Parkinsonism and Related Disorders - October 27, 2009 Category: Neurology Authors: Harrison C. Walker, Michael Lyerly, Gary Cutter, Johnson Hagood, Natividad P. Stover, Stephanie L. Guthrie, Barton L. Guthrie, Ray L. Watts Tags: Short Communications Source Type: journals

The role of rehabilitation in deep brain stimulation of the subthalamic nucleus for Parkinson's disease: A pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an efficacious therapeutic option in the treatment of advanced Parkinson's disease (PD). The procedure may be however associated with functional impairment of different types and intensity. In this paper we describe the functional impairments detected in a group of 34 subjects with PD who were submitted to DBS. These patients belonged to a cohort of 75 consecutive PD patients who underwent the surgical procedure. The rehabilitation program included physiotherapy exercises for recovery/maintenance of the range of motion, active exercises, e...
Source: Parkinsonism and Related Disorders - October 27, 2009 Category: Neurology Authors: Cristina Tassorelli, Simona Buscone, Giorgio Sandrini, Claudio Pacchetti, Anna Furnari, Roberta Zangaglia, Michelangelo Bartolo, Giuseppe Nappi, Emilia Martignoni Tags: Papers Source Type: journals

No need to droop your head in Parkinson's disease?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Over the last years increasing numbers of patients with dropped head/bent spine syndrome have been reported. Neuromuscular specialists observed this syndrome in a wide range of disorders including motor neurone disease, inflammatory neuropathies, neuromuscular junction disorders and inflammatory and hereditary myopathies . Some movement disorder specialists proposed axial dystonia as underlying mechanism of dropped head/bent spine syndrome in patients with Parkinson's disease (PD) or atypical parkinsonian disorders such as multiple system atrophy (MSA) . A partial or rarely complete response to high-dose dopaminergic treat...
Source: Parkinsonism and Related Disorders - October 27, 2009 Category: Neurology Authors: Wolfgang N. Loscher, Gregor K. Wenning Tags: Editorial Source Type: journals

Deep Brain Stimulation May Be Effective Treatment For Tourette SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deep brain stimulation may be a safe and effective treatment for Tourette syndrome, according to research published in the October 27, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 27, 2009 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Deep brain stimulation may be effective treatment for Tourette's syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(American Academy of Neurology) Deep brain stimulation may be a safe and effective treatment for Tourette's syndrome, according to research published in the October 27, 2009, print issue of Neurology, the medical journal of the American Academy of Neurology. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - October 27, 2009 Category: Global & Universal Source Type: news

Deep Brain Stimulation May Help in Tourette SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thalamic deep brain stimulation reduces tic severity in patients with severe and refractory Tourette syndrome, and also improves symptoms of anxiety and depression, according to a study in the Oct. 27 issue of Neurology. (Source: Modern Medicine)
Source: Modern Medicine - October 27, 2009 Category: Journals (General) Source Type: info

Deep brain stimulation for Tourette syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - October 26, 2009 Category: Neurology Authors: Black, K. J. Tags: PATIENT PAGES Source Type: journals

Thalamic deep brain stimulation for treatment-refractory Tourette syndrome: Two-year outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: At 24-month follow-up, tic severity was improved in patients with intractable Tourette syndrome (TS) who underwent bilateral thalamic deep brain stimulation. Available data from 15 of 18 patients also showed that neuropsychiatric symptoms were improved and cognitive performances were not disadvantaged. Controlled studies on larger cohorts with blinded protocols are needed to verify that this procedure is effective and safe for selected patients with TS. Level of evidence: This study provides class IV evidence that bilateral thalamic deep brain stimulation reduces global tic severity measured 24 months after im...
Source: Neurology - October 26, 2009 Category: Neurology Authors: Porta, M., Brambilla, A., Cavanna, A. E., Servello, D., Sassi, M., Rickards, H., Robertson, M. M. Tags: Tourette syndrome, Tics, Neuropsychological assessment, All Psychiatric disorders, Class IV ARTICLES Source Type: journals

Therapeutic Brain Stimulation for EpilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article concentrates on clinical studies of DBS for epilepsy. (Source: Neurologic Clinics)
Source: Neurologic Clinics - October 24, 2009 Category: Neurology Authors: Juliana Lockman, Robert S. Fisher Source Type: journals

PrefaceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The diagnosis and management of patients who have epilepsy have greatly evolved over recent years. This issue of Neurologic Clinics presents state-of-the-art reviews by renowned experts of critical issues that illustrate this evolution and underscore their importance in the care of patients. The first six papers focus on the interrelationships between seizures and psychological, neuropsychological, and hormonal factors. The next five papers discuss pharmacologic treatment selection, drug resistance, approaches to localizing seizure onset, and deep brain stimulation as a possible non-pharmacological intervention. The final ...
Source: Neurologic Clinics - October 24, 2009 Category: Neurology Authors: Steven C. Schachter Source Type: journals

Induction of panic attack by stimulation of the ventromedial hypothalamus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Panic attacks are sudden debilitating attacks of intense distress often accompanied by physical symptoms such as shortness of breath and heart palpitations. Numerous brain regions, hormones, and neurotransmitter systems are putatively involved, but the etiology and neurocircuitry of panic attacks is far from established. One particular brain region of interest is the ventromedial hypothalamus (VMH). In cats and rats, electrical stimulation delivered to the VMH has been shown to evoke an emotional "panic attack-like" escape behavior, and in humans, stimulation targeting nuclei just posterior or anterior to the VMH has r...
Source: Journal of Neurosurgery - October 23, 2009 Category: Neurosurgery Authors: Wilent WB, Oh MY, Buetefisch CM, Bailes JE, Cantella D, Angle C, Whiting DM Tags: J Neurosurg Source Type: journals

Chronic Deep Brain Stimulation for Segmental DystoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stereotact Funct Neurosurg 2009;87:379-384 (DOI:10.1159/000249819) (Source: Karger Publishers)
Source: Karger Publishers - October 20, 2009 Category: Cancer & Oncology Source Type: journals

Effects of DBS on precision grip abnormalities in essential tremor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deep brain stimulation (DBS) of the ventrolateral thalamus is a highly effective procedure for the treatment of essential tremor (ET). The regularity of repetitive, self-paced finger tapping is known to be abnormal in patients with ET and improved following DBS. However, the more complex timing that underlies force development in the hands in ET and after DBS has not been evaluated. In this pilot study, we assessed precision grip performance in seven ET subjects before and after 5 months of DBS. Ten healthy controls were also studied. ET subjects showed a significant increase in preload duration (235 +/- 145 vs. 82 +/-...
Source: Experimental Brain Research - October 20, 2009 Category: Neuroscience Authors: Stani TM, Burchiel KJ, Hart MJ, Lenar DP, Anderson VC Tags: Exp brain Res Source Type: journals

Federal Register: The Neurological Devices Panel of the Medical Devices Advisory Committee; Notice of MeetingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On November 20, 2009, the committee will discuss, make recommendations and vote on a premarket approval application for the Deep Brain Stimulation System for Epilepsy sponsored by Medtronic, Inc. (Source: Food and Drug Adminstration (FDA): CDRHNew)
Source: Food and Drug Adminstration (FDA): CDRHNew - October 16, 2009 Category: Medical Equipment Source Type: organizations

Bilateral subthalamotomy through dbs electrodes: a rescue option for device-related infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - October 12, 2009 Category: Neurology Authors: Deligny, C., Drapier, S., Verin, M., Lajat, Y., Raoul, S., Damier, P. Tags: Abscess, Bacterial infections, parkinson's disease/parkinsonism CLINICAL/SCIENTIFIC NOTES Source Type: journals