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Columnar cell lesions and pseudoangiomatous hyperplasia like stroma: is there an epithelial-stromal interaction?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The significance of association between cancer and its microenvironment has been increasingly recognized. It has been shown in animal models that interaction between neoplastic epithelial cells and adjacent stroma can modulate tumor behavior. Carcinoma associated stromal cells can transform normal epithelial cells into neoplastic cells. In breast, columnar cell lesions are non-obligate precursors of low grade ductal carcinoma in situ. Columnar cell lesions can be seen intimately associated with PASH-like-stroma, a lesion we termed as CCPLS. Our aim is to investigate epithelial-stromal interactions in CCPLS and compare ...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Recavarren RA, Chivukula M, Carter G, Dabbs DJ Tags: Int J Clin Exp Pathol Source Type: journals

Small invasive ductal carcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes a case of small adenocarcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm (IPMN) in which investigation by EUS took place every 6 mo and diagnosis was made accurately by additional CEH-EUS during the follow-up of the branch duct IPMN. A 68-year-old female was admitted to our hospital because of a branch duct IPMN in the pancreatic body. She had been followed-up by EUS every 6 mo. However, after 2 years EUS demonstrated a low echoic area distinct from the branch duct IPMN which was vaguely discernible by EUS, and accurate sizing and differential diagnosis were con...
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Sakamoto H, Kitano M, Komaki T, Imai H, Kamata K, Kimura M, Takeyama Y, Kudo M Tags: World J Gastroenterol Source Type: journals

Clinical Implications of Subcategorizing BI-RADS 4 Breast Lesions associated with Microcalcification: A Radiology–Pathology Correlation StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Currently radiologists have the option of subcategorizing BI-RADS 4 breast lesions into 4A (low suspicion for malignancy), 4B (intermediate suspicion of malignancy), and 4C (moderate concern, but not classic for malignancy). To determine the clinical significance of BI-RADS 4 subcategories and the common pathologic changes associated with these mammographic lesions, a retrospective review of 239 consecutive stereotactic-needle core biopsies (SNCB) for microcalcifications was performed. All 239 SNCBs were BI-RADS 4 lesions, and of these, 191 were subcategorized to 4A, 4B or 4C. Ninety-four of 191 (49%) were 4A, 73...
Source: The Breast Journal - November 19, 2009 Category: Cancer & Oncology Authors: Mary Ann Sanders, Lane Roland, Sunati Sahoo Source Type: journals

Magnetic Resonance Imaging Screening of the Contralateral Breast in Women With Newly Diagnosed Breast Cancer: Systematic Review and Meta-Analysis of Incremental Cancer Detection and Impact on Surgical Management [REVIEW ARTICLE]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion MRI detects contralateral lesions in a substantial proportion of women, but does not reliably distinguish benign from malignant findings. Relatively high ICDR may be due to selection bias and/or overdetection. Women must be informed of the uncertain benefit and potential harm, including additional investigations and surgery. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Brennan, Houssami, Lord, Macaskill, Irwig, Dixon, Warren, Ciatto Tags: Diagnosis & Staging REVIEW ARTICLE Source Type: journals

Declining recurrence among ductal carcinoma in situ patients treated with breast-conserving surgery in the community settingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The marked increase in the 1990s in the use of adjuvant therapy for DCIS patients treated with BCS in the community setting only partially explains the 50% decline in risk of recurrence risk. Changes in pathology factors have likely also contributed to this decline. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 18, 2009 Category: Cancer & Oncology Authors: Laurel HabelNinah AchacosoReina HaqueLarissa NekhlyudovSuzanne FletcherStuart SchnittLaura CollinsAnn GeigerBalaram PuligandlaLuana ActonCharles Quesenberry Source Type: journals

Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Similar to adenomas, MGA is, at least in some cases, a clonal lesion and may be a non-obligate precursor of a subgroup of high-grade triple-negative and basal-like breast carcinomas. (Source: Histopathology)
Source: Histopathology - November 17, 2009 Category: Pathology Authors: Felipe C Geyer, Yael B Kushner, Maryou B Lambros, Rachael Natrajan, Alan Mackay, Narinder Tamber, Kerry Fenwick, Dave Purnell, Alan Ashworth, Rosemary A Walker, Jorge S Reis-Filho Source Type: journals

Excision alone inadequate for high grade DCISEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Excision alone is inadequate treatment for patients with high-grade ductal carcinoma in situ, but may be suitable for patients with low- or intermediate-grade lesions, US study findings indicate. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - November 13, 2009 Category: Cancer & Oncology Source Type: news

Excision alone inadequate for high grade DCISEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Excision alone is inadequate treatment for patients with high-grade ductal carcinoma in situ, but may be suitable for patients with low- or intermediate-grade lesions, US study findings indicate. (Source: MedWire News - Breast Cancer)
Source: MedWire News - Breast Cancer - November 13, 2009 Category: Cancer & Oncology Source Type: news

Can breast MRI computer-aided detection (CAD) improve radiologist accuracy for lesions detected at MRI screening and recommended for biopsy in a high-risk population?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The breast MRI CAD system used could not improve the radiologists' accuracy for distinguishing all malignant from benign lesions, due to the poor sensitivity for DCIS detection. (Source: Clinical Radiology)
Source: Clinical Radiology - November 12, 2009 Category: Radiology Authors: T. Arazi-Kleinman, P.A. Causer, R.A. Jong, K. Hill, E. Warner Tags: Original Articles Source Type: journals

Correction: Parathyroid Hormone-Related Protein Protects against Mammary Tumor Emergence and Is Associated with Monocyte Infiltration in Ductal Carcinoma In situEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cancer Research)
Source: Cancer Research - November 12, 2009 Category: Cancer & Oncology Tags: Corrections Source Type: journals

A unique proteolytic fragment of alpha1-antitrypsin is elevated in ductal fluid of breast cancer patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, elevated C-41/42 is likely the result of elevated AAT synthesis, and the activity of specific MMPs present within the tumor. As other C-terminal fragments of AAT are reported to function as tumor-derived suppressors to the host immune-system, elevated C-41/42 may also be predictive of a poor outcome. Content Type Journal ArticleCategory Preclinical studyDOI 10.1007/s10549-009-0625-5Authors Junma Zhou, Johns Hopkins Medical Institutions Department of Pathology Baltimore MD 21287 USABruce Trock, Johns Hopkins Medical Institutions Department of Urology Baltimore MD 21287 USATheodore N. Tsangaris, Johns H...
Source: Breast Cancer Research and Treatment - November 9, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals

Comparison of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) assessment for Her-2 status in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a prospective study to reflect the concordance between IHC and FISH in Guilin city, People's Republic of China. Methods: Fifty cases of invasive ductal carcinoma of breast tested by IHC and scored as 0, 1+, 2+ and 3+ by pathologists were further analyzed by FISH using a commercially available double-color probe, and the FISH findings were compared with IHC testresults. Results: A total concordance of 82.0% was observed with a Kappa coefficient of 0.640 (P (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - November 9, 2009 Category: Cancer & Oncology Authors: Weiguo SuiMinglin OuJiejing ChenYouhua WanHongbo PengMinfang QiHe HuangYong Dai Source Type: journals

Breast Cancer Deception Month: Hiding the Truth beneath a Sea of Pink, Part VEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) As we near the end of Breast Cancer Awareness Month, once again our country has been awash from shore to shore in a sea of pink - from pink ribbons and donation boxes to pink products, charity promotions, celebrities by the score and even pink cleats on NFL players. Tragically, most people are unaware of the dark history of Breast Cancer Awareness Month (BCAM) and of the players past and present who have misused it to direct people and funds away from finding a true cure, while covering up their own roles in causing and profiting from cancer.In this installment of the series, we will examine the dangers of ov...
Source: NaturalNews.com - November 8, 2009 Category: Consumer Health Advice Source Type: news

Clinical Dilemma of Ductal Carcinoma in Situ [EDITORIALS]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Authors: Harris, Morrow Tags: EDITORIALS Source Type: journals

Local Excision Alone Without Irradiation for Ductal Carcinoma In Situ of the Breast: A Trial of the Eastern Cooperative Oncology Group [Breast Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Rigorously evaluated and selected patients with low- to intermediate-grade DCIS with margins 3 mm or wider had an acceptably low rate of ipsilateral breast events at 5 years after excision without irradiation. Patients with high-grade lesions had a much higher rate, suggesting that excision alone is inadequate treatment. Further follow-up is necessary to document long-term results. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Authors: Hughes, Wang, Page, Gray, Solin, Davidson, Lowen, Ingle, Recht, Wood Tags: Combined Modality Breast Cancer Source Type: journals

Analysis of the expression of hyaluronan in intraductal and invasive carcinomas of the breastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our study indicates a proportionally higher area of hyaluronan expression in DCIS with a microinvasive component than in pure DCIS, suggesting a key role of this glycosaminoglycan in the early invasive phase of breast carcinomas. Thus, hyaluronan could play an important function in determining the migratory phenotype of cancer cells. Larger size tumors appear to demonstrate an intricate balance between hyaluronan synthesis and degradation, thus conditioning intratumoral heterogeneity in the hyaluronan metabolism. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-071...
Source: Journal of Cancer Research and Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Ductal Carcinoma In Situ — A Highly Treatable Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Doctors and their patients with a specific type of breast cancer called ductal carcinoma in situ (DCIS) are successfully employing treatments to beat the disease, with 10-year survival rates approaching nearly 100 percent. (Source: Mayo Clinic Health Information)
Source: Mayo Clinic Health Information - November 5, 2009 Category: Consumer Health Advice Authors: Mayo Clinic Source Type: organizations

Risk of carcinoma after subsequent excision of benign papilloma initially diagnosed with an ultrasound (US)-guided 14-gauge core needle biopsy: a prospective observational studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Surgical excision should be considered for benign intraductal papillomas above 1.5 cm in size. Content Type Journal ArticleCategory BreastDOI 10.1007/s00330-009-1649-2Authors Jung Min Chang, Seoul National University Hospital and the Institute of Radiation Medicine, Seoul National University Medical Research Center Department of Radiology and Clinical Research Institute Chongno-gu Seoul Republic of KoreaWoo Kyung Moon, Seoul National University Hospital and the Institute of Radiation Medicine, Seoul National University Medical Research Center Department of Radiology and Clinical Research...
Source: European Radiology - November 4, 2009 Category: Radiology Tags: European Radiology Source Type: journals

Correlated expression of peroxisome proliferator-activated receptor γ with high histologic grade and basal type in invasive ductal carcinoma of the breastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PPAR[gamma] expression is related to poor prognostic factors of breast cancer. It is considered that PPAR[gamma] has evident tumor promoting properties in vivo, but receptor-independent effects of PPAR[gamma] ligands may compound its biologic effects in cancer. A better understanding of action mechanisms of the activated PPAR[gamma] is required. (Source: Basic and Applied Pathology)
Source: Basic and Applied Pathology - November 4, 2009 Category: Pathology Authors: Hoiseon Jeong, Youngseok Lee, Jungsuk An, Ok Hee Woo, KyongHwa Park, Aeree Kim Source Type: journals

Circulating levels of matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and their compex MMP-9/NGAL in breast cancer diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL) expression is induced in many types of human cancer, while detection of its complex with matrix metalloproteinase-9 (MMP-9) is correlated with cancer disease status. We aim to evaluate the serum expression of MMP-9, NGAL and their complex (MMP-9/NGAL) during the diagnostic work-up of women with breast abnormalities and investigate their correlation with disease severity. Methods: The study included 113 women with non-palpable breast lesions undergoing vacuum-assisted breast biopsy for histological diagnosis, and 30 healthy women, wh...
Source: BMC Cancer - November 4, 2009 Category: Cancer & Oncology Authors: Xeni ProvatopoulouAntonia GounarisEleni KalogeraFlora ZagouriIoannis FlessasEvgenios GoussetisAfroditi NonniIoannis PapassotiriouGeorge Zografos Source Type: journals

In Atypical Ductal Hyperplasia, Absence of Cytokeratin 5 Expression Is OminousEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cytokeratin 5 (CK5) expression in breast tissue indicates ductal carcinoma in situ, even if the patient presents with atypical ductal hyperplasia; the presence of CK5 is a good prognosticator. Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - November 3, 2009 Category: Internal Medicine Tags: Pathology & Lab Medicine Source Type: info

Acinar cell carcinoma of the pancreas with intraductal growth: Report of a caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Acinar cell carcinomas (ACCs) of the pancreas are rare neoplasms, accounting for approximately 1% of all exocrine pancreatic tumors. This type of tumor is known to be aggressive, although the survival rates are somewhat better than they are for ductal carcinoma. The tumor tends to present nonspecific symptoms. It occurs in older patients, and jaundice is infrequent. This report presents a case of ACC of the pancreas with intraductal papillary growth and lymph node metastasis. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00595-009-3968-yAuthors Masafumi Imamura, Sapporo Medical Un...
Source: Surgery Today - November 2, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Ductal carcinoma in situ: X-ray fluorescence microscopy and dynamic contrast-enhanced MR imaging reveals gadolinium uptake within neoplastic mammary ducts in a murine model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results provide insight into the physiologic basis of contrast enhancement of DCIS lesions on DCE MR images: Gadolinium penetrates and collects inside neoplastic ducts. PMID: 19864527 [PubMed - in process] (Source: Radiology)
Source: Radiology - November 1, 2009 Category: Radiology Authors: Jansen SA, Paunesku T, Fan X, Woloschak GE, Vogt S, Conzen SD, Krausz T, Newstead GM, Karczmar GS Tags: Radiology Source Type: journals

DCIS More Likely to Recur in Younger WomenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women younger than age 45 years who were treated with lumpectomy and radiation for ductal carcinoma in situ were 68% more likely to have a local recurrence than were older women, a large population-based study found. (Source: Internal Medicine News)
Source: Internal Medicine News - November 1, 2009 Category: Internal Medicine Authors: SHERRY BOSCHERT Tags: Women's Health Source Type: journals

Apocrine ductal carcinoma in situ involving a sclerosing lesion with adenosis: report of a case.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Apocrine metaplasia is a ubiquitous component of the mammary fibrocystic change spectrum. Although mostly associated with cysts, apocrine metaplasia can also present as a proliferative lesion, rarely with cytologic atypism. Apocrine atypia is characterized by 3-fold nuclear enlargement, multiple nucleoli, and hyperchromatism and generally arises in florid adenosis or radial sclerosing lesions. Dramatic apocrine atypia may be very difficult to distinguish from apocrine ductal carcinoma in situ. The latter is distinguished from apocrine atypia by greater extent of the lesion (>0.4 cm) and the presence of greater nucle...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Visscher DW Tags: Arch Pathol Lab Med Source Type: journals

Diane Foresee SurvivorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breast cancer survivor Diane Foresee has dealt with two different types of breast cancer: invasive ductal carcinoma and inflammatory breast cancer. She faced her fears, educated herself, and plunged into chemotherapy, radiation, and Herceptin treatments. Diane is a woman of faith, and here she tells her breast cancer survivor story. (Source: About.com Breast Cancer)
Source: About.com Breast Cancer - October 31, 2009 Category: Cancer & Oncology Authors: breastcancer.guide at about.com Tags: health Source Type: consumer

The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special typeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Invasive lobular carcinoma (ILC) is the most frequent special type of breast cancer. The majority of these tumours are of low histological grade, express hormone receptors, and lack HER2 expression. The pleomorphic variant of ILCs (PLCs) is characterized by atypical cells with pleomorphic nuclei and is reported to have an aggressive clinical behaviour. Expression profiling studies have demonstrated that classic ILCs preferentially display a luminal phenotype, whereas PLCs may be of luminal, HER2 or molecular apocrine subtypes. The aims of this study were two-fold: to determine the transcriptomic characteristics of lobular ...
Source: The Journal of Pathology - October 30, 2009 Category: Pathology Authors: Britta Weigelt, Felipe C Geyer, Rachael Natrajan, Maria A Lopez-Garcia, Amar S Ahmad, Kay Savage, Bas Kreike, Jorge S Reis-Filho Source Type: journals

Assessment of false-negative cases of breast MR imaging in women with a familial or genetic predispositionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In order to assess the characteristics of malignant breast lesions those were not detected during screening by MR imaging. In the Dutch MRI screening study (MRISC), a non-randomized prospective multicenter study, women with high familial risk or a genetic predisposition for breast cancer were screened once a year by mammography and MRI and every 6 months with a clinical breast examination (CBE). The false-negative MR examinations were subject of this study and were retrospectively reviewed by two experienced radiologists. From November 1999 until March 2006, 2,157 women were eligible for study ...
Source: Breast Cancer Research and Treatment - October 29, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals

Invasive ductal carcinoma within fibroadenoma: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There is a low percentage of fibroadenomas harboring carcinoma; however, all breast lumps should be seriously managed; extirpation and histological examination is recommended (Source: BioMed Central)
Source: BioMed Central - October 29, 2009 Category: Journals (General) Authors: Lumturije Gashi-LuciRine LimaniFisnik Kurshumliu Source Type: journals

Study Finds Benefits With Full-Field Digital MammographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Full-field digital mammography, along with computer-aided diagnosis, may provide improved detection of microcalcifications and ductal carcinoma in situ, according to research published in the November issue of Radiology. (Source: Modern Medicine)
Source: Modern Medicine - October 29, 2009 Category: Journals (General) Source Type: info

Why Do Purely Intraductal Cancers Enhance on Breast MR Images? [Science to Practice]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On the basis of the results of the animal study performed by Jansen et al and clinical observations, there is compelling evidence to suggest that the imaging phenotype of a ductal carcinoma in situ (DCIS) lesion (its detectability at mammography and MR imaging, specifically the presence or absence of calcifications on mammograms and the presence or absence of calcifications and the degree of their enhancement on MR images) conveys important biologic information that will be useful when guiding DCIS treatment. (Source: Radiology)
Source: Radiology - October 28, 2009 Category: Radiology Authors: Kuhl, C. K. Tags: Science to Practice Source Type: journals

Breast Cancer Screening Results 5 Years after Introduction of Digital Mammography in a Population-based Screening Program [Breast Imaging]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results indicate that with full-field digital mammography (FFDM) using computer-aided diagnosis (CAD) and double reading, the detection is as good as that with screen-film mammography, and detection of clustered microcalcifications and ductal carcinoma in situ is improved with FFDM using CAD. (Source: Radiology)
Source: Radiology - October 28, 2009 Category: Radiology Authors: Karssemeijer, N., Bluekens, A. M., Beijerinck, D., Deurenberg, J. J., Beekman, M., Visser, R., van Engen, R., Bartels-Kortland, A., Broeders, M. J. Tags: Breast Imaging Source Type: journals

Ductal Carcinoma in Situ: X-ray Fluorescence Microscopy and Dynamic Contrast-enhanced MR Imaging Reveals Gadolinium Uptake within Neoplastic Mammary Ducts in a Murine Model [Experimental Studies]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We used a transgenic mouse model of breast cancer to investigate contrast enhancement of ductal carcinoma in situ (DCIS) on clinical dynamic contrast material–enhanced (DCE) MR images of the breast, and we have shown via two independent routes—DCE MR imaging and x-ray fluorescence microscopy—that after injection of gadodiamide, there is gadolinium uptake inside ducts distended with murine DCIS. (Source: Radiology)
Source: Radiology - October 28, 2009 Category: Radiology Authors: Jansen, S. A., Paunesku, T., Fan, X., Woloschak, G. E., Vogt, S., Conzen, S. D., Krausz, T., Newstead, G. M., Karczmar, G. S. Tags: Experimental Studies Source Type: journals

CpG Hypomethylation of MDR1 Gene in Tumor and Serum of Invasive Ductal Breast Carcinoma Patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hypomethylation of MDR1 promoter in IDCs accounted for P-gp overexpression and aggressive biologic behavior in a subset of patients. Detection of these epigenetic changes in circulating DNA may not only enhance insight into the biological behavior of the primary tumor of an individual, but may also provide valuable information regarding prognosis that can be readily monitored throughout the disease course. PMID: 19879256 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - October 28, 2009 Category: Biochemistry Authors: Sharma G, Mirza S, Parshad R, Srivastava A, Dattagupta S, Pandya P, Ralhan R Tags: Clin Biochem Source Type: journals

For DCIS, Outcomes With Excision Alone Acceptable at 5 YearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new study begs the question of whether or not local surgery alone is acceptable as a treatment option for women with ductal carcinoma in situ (DCIS). Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 27, 2009 Category: Consumer Health News Tags: Hematology-Oncology Source Type: news

Women's HealthSource Highlights Ductal Carcinoma In SituEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Doctors and their patients with a specific type of breast cancer called ductal carcinoma in situ (DCIS) are successfully employing treatments to beat the disease, with 10-year survival rates approaching nearly 100 percent. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - October 27, 2009 Category: Cancer & Oncology Source Type: news

Serum protein signature may improve detection of ductal carcinoma in situ of the breastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
e & A Mangé (Source: Oncogene)
Source: Oncogene - October 26, 2009 Category: Cancer & Oncology Authors: J SolassolP RouanetP J LamyC AllalG FavreT MaudelondeA Mangé Source Type: journals

Should pathologists send all or only selected slides for patient-requested interlaboratory second opinion?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For interlaboratory second opinions requested by patients or clinicians, whether all or selected slides should be sent is unknown. We compared the disagreement rate for requested second opinions for 4 years of sending selected slides with the rate for 1 year of sending all slides. Disagreements were identified in 81 (13.6%) of 596 cases (468 selected slides, 128 all slides). The disagreement rate was less when sending selected slides (n = 58 [12%]) vs all slides (n = 23 [18%]; P = .03). Only 5 cases were identified with disagreement related to whether all or selected slides were sent (selected slides, 1 case [slide of ...
Source: American Journal of Clinical Pathology - October 24, 2009 Category: Pathology Authors: Renshaw MA, Renshaw AA, Gould EW Tags: Am J Clin Pathol Source Type: journals

Local Excision Alone Without Irradiation for Ductal Carcinoma in Situ of the Breast: A Trial of the Eastern Cooperative Oncology GroupEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this prospective analysis, women with low- and intermediate-grade ductal carcinoma in situ of the breast (n = 565) were at low risk (6%) for recurrence at 5 years after excision without radiation therapy.... Access... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - October 24, 2009 Category: Cancer & Oncology Source Type: journals

Predictive factors for breast cancer in patients diagnosed atypical ductal hyperplasia at core needle biopsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Age (over 50-years) at the time of biopsy is an independent predictive factor for breast cancer at surgical excision in patients with diagnosed ADH at CNB. For patients diagnosed with ADH at CNB, only complete surgical excision is the suitable treatment option, because we could not find any combination of factors that can safely predict the absence of DCIS or invasive cancer in a case of ADH. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - October 22, 2009 Category: Cancer & Oncology Authors: Byung Joo ChaeAhwon LeeByung Joo SongSang Seol Jung Source Type: journals

Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Malignant ascites may be the first presentation of an unsuspected cancer. Pancreas and ovary are among the organs that are usually evaluated as a source of primary. The purpose of this study is to investigate a panel of immunohistochemical stains to help differentiate pancreatic from ovarian carcinoma. We evaluated the immunohistochemical staining of eight commercially available antibodies MUC1, MUC2, MUC5ac, Wilm's tumor susceptibility gene 1 (WT1), cytokeratin 7 (CK7), CK20, CA125, and CA19.9 in 25 effusion specimens with evidence of metastatic carcinoma including 14 ovarian serous carcinomas, 9 pancreatic adenocarcinoma...
Source: Diagnostic Cytopathology - October 22, 2009 Category: Pathology Authors: Liying Han, Vaishali Pansare, Mousa Al-Abbadi, Mujtaba Husain, Jining Feng Source Type: journals

The association of metabolic syndrome with triple-negative breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Metabolic syndrome, a conglomerate of obesity, insulin resistance, dyslipidemia, and hypertension has been linked with an increased risk of breast cancer. We investigated the possible association of highly aggressive triple-negative breast cancer and the metabolic syndrome. Information on metabolic syndrome components and tumor characteristics were reviewed in a cohort of 176 patients (including 86 triple-negatives). Retrospective comparison was performed using Pearson Chi-square test or Student’s t test for data analysis. A statistically significant association of triple-negative breast cancer wi...
Source: Breast Cancer Research and Treatment - October 22, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals

High-risk human papilloma virus infection, tumor pathophenotypes, and BRCA1/2 and TP53 status in juvenile breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Juvenile breast cancer is rare and poorly known. We studied a series of five breast cancer patients diagnosed within 25 years of age that included two adolescents, 12- and 15-years-old, and 3 young women, 21-, 21-, and 25-years-old, respectively. All cases were scanned for germline mutations along the entire BRCA1/2 coding sequences and TP53 exons 4–10, using protein truncation test, denaturing high performance liquid chromatography and direct sequencing. Paraffin-embedded primary tumors (available for 4/5 cases), and a distant metastasis (from the 15-years-old) were characterized for histolog...
Source: Breast Cancer Research and Treatment - October 22, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals

The Confusion Over DCIS: What to Do About 'Stage Zero' Breast Cancer?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abnormal cells proliferating in a breast duct means surgery (at least). Will it always be that way? (Source: U.S. News - Health)
Source: U.S. News - Health - October 22, 2009 Category: Consumer Health News Source Type: consumer

What is an Adequate Margin for Breast-Conserving Surgery? Surgeon Attitudes and CorrelatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Wide variation in BCS margin definition exists. Variation is similar for invasive cancer and DCIS with RT, with more specialized surgeons choosing smaller margins. In DCIS without RT, more specialized surgeons favored larger margins. A standardized margin definition may significantly affect re-excision rates. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-009-0765-1Authors Michelle Azu, Memorial Sloan-Kettering Cancer Center Breast Service, Department of Surgery New York USAPaul Abrahamse, University of Michigan Department of Internal Medicine Ann Arbor MI USASteven...
Source: Annals of Surgical Oncology - October 22, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Utility of an upright-type 11-gauge stereotactic vacuum-assisted biopsy device (Mammotome®) for the diagnosis of breast microcalcificationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The upright stereotactic 11-gauge Mammotome procedure is an effective and reliable method for the diagnosis of breast microcalcifications. It has minimal side effects. For lesions diagnosed as ADH or DCIS with the 11-gauge Mammotome, subsequent surgical excision should be performed. Content Type Journal ArticleDOI 10.1007/s10330-009-0100-0Authors Ming Yang, the First Hospital of Jilin University Department of Breast Surgery Changchun 130021 ChinaTakanori Ishida, Tohoku University School of Medicine Department of Surgical Oncology Sendai JapanMotohiro Takeda, Tohoku University School of Medi...
Source: The Chinese-German Journal of Clinical Oncology - October 21, 2009 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: journals

Is pancreatectomy with arterial reconstruction a safe and useful procedure for locally advanced pancreatic cancer?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Further discussion is required concerning surgical indications and significance. However, it is thought that resection is useful only when surgery of R0 has taken place for selected locally advanced pancreatic cancer (M0). Content Type Journal ArticleCategory Original articleDOI 10.1007/s00534-009-0190-7Authors Hodaka Amano, Teikyo University School of Medicine Department of Surgery 2-11-1 Kaga-cho, Itabashi-ku Tokyo 173-8605 JapanFumihiko Miura, Teikyo University School of Medicine Department of Surgery 2-11-1 Kaga-cho, Itabashi-ku Tokyo 173-8605 JapanNaoyuki Toyota, Teikyo University Scho...
Source: Journal of Hepato-Biliary-Pancreatic Surgery - October 21, 2009 Category: Surgery Tags: Journal of Hepato-Biliary-Pancreatic Surgery Source Type: journals

Impact of Pathological Characteristics on Local Relapse After Breast-Conserving Therapy: A Subgroup Analysis of the EORTC Boost Versus No Boost Trial [Breast Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Young age and high-grade invasive ductal cancer were the most important risk factors for local relapse, while margin status had no significant influence. A boost dose of 16 Gy significantly reduced the negative effects of both young age and high-grade invasive cancer. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Jones, Antonini, Hart, Peterse, Horiot, Collin, Poortmans, Oei, Collette, Struikmans, Van den Bogaert, Fourquet, Jager, Schinagl, Warlam-Rodenhuis, Bartelink Tags: Surgery, Radiation, Prognostic Studies, Radiation Oncology, Surgical Oncology Breast Cancer Source Type: journals

Occult Nipple Involvement in Breast Cancer: Clinicopathologic Findings in 316 Consecutive Mastectomy Specimens [Breast Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Nipple-sparing mastectomy may be suitable for selected cases of breast carcinoma with low probability of nipple involvement by carcinoma and prophylactic procedures. A retroareolar en-face margin may be used to test for occult involvement in patients undergoing nipple-sparing mastectomy. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Brachtel, Rusby, Michaelson, Chen, Muzikansky, Smith, Koerner Tags: Diagnosis & Staging Breast Cancer Source Type: journals

Significance of nipple enhancement of Paget’s disease in contrast enhanced breast MRIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion CE breast MRI allows for the correct detection of nipple involvement of Paget’s disease even when clinical information or mammographic/US findings are not provided. Content Type Journal ArticleCategory General GynecologyDOI 10.1007/s00404-009-1244-4Authors Hyeon Sook Kim, The Catholic University of Korea Department of Radiology, St. Paul’s Hospital, College of Medicine Seoul KoreaJee Hyun Seok, The Catholic University of Korea Department of Radiology, St. Mary’s Hospital, College of Medicine Seoul KoreaEun Suk Cha, The Catholic University of Korea Department of Radiology, St. Vincent�...
Source: Archives of Gynecology and Obstetrics - October 16, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals