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Impact of target volumes and radiation technique on loco-regional control and survival for patients with unilateral cervical lymph node metastases from an unknown primary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Retrospective comparisons between bilateral and unilateral neck radiotherapies did not show differences in terms of loco-regional control and survival. However, patient's local regional control and survival are significantly improved after 3D-CRT or IMRT. PMID: 19892420 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 4, 2009 Category: Radiology Authors: Ligey A, Gentil J, Créhange G, Montbarbon X, Pommier P, Peignaux K, Truc G, Maingon P Tags: Radiother Oncol Source Type: journals

[Definitive treatment of anal canal carcinoma with radiotherapy: Adverse impact of a pre-radiation resection. A retrospective study of 57 patients treated with curative intent.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Radiotherapy and chemoradiation with cisplatine-based chemotherapy cure a vast majority of patients with epidermoid carcinoma of the anal canal. Therapeutic factors that may interfere with the definition of the target volume and the patients' repositioning may decrease the efficacy of radiotherapy. Pre-radiotherapy surgical resection should be avoided. PMID: 19854092 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 22, 2009 Category: Cancer & Oncology Authors: Coquard R, Cenni JC, Artru P, Chalabreysse P, Queneau PE, Taieb S, Alessio A, Lledo G Tags: Cancer Radiother Source Type: journals

[TNF-alpha inhibitor etanercept and oral cavity carcinoma.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DISCUSSION: The possible development of an oral cavity carcinoma should be taken into account when following a patient under TNF-alpha inhibitor treatment. Anti-TNF treatment has improved the management of patients with severe chronic inflammatory diseases. They allow for a better quality of life. Nevertheless, their immunosuppressive effect should be taken into account when prescribed and during follow-up. PMID: 19836037 [PubMed - as supplied by publisher] (Source: Revue de Stomatologie et de Chirurgie Maxillo-Faciale)
Source: Revue de Stomatologie et de Chirurgie Maxillo-Faciale - October 13, 2009 Category: ENT & OMF Authors: Rousseau A, Taberne R, Siberchicot F, Fricain JC, Zwetyenga N Tags: Rev Stomatol Chir Maxillofac Source Type: journals

Essential Oil of Artemisia Capillaris Induces Apoptosis in KB Cells via Mitochondrial Stress and Caspase Activation Mediated by MAPK-Stimulated Signaling PathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined whether or not the essential oil isolated from A. capillaris induces apoptosis in the human oral epidermoid carcinoma cells along with the possible mechanism(s) of the essential oil-mediated cytotoxicity. The essential oil induced cell death of KB cells through apoptosis, as evidenced by the increased cell population in the sub-G1 phase, the appearance of condensed and/or fragmented nuclei, and the generation of a cleaved PARP product. Treating the cells with the oil also caused changes in the mitochondrial level of the Bcl-2 family proteins such as Bcl-2 and Bax, thereby inducing the release of cytochr...
Source: Journal of Food Science - October 12, 2009 Category: Food Science Authors: Jeong-Dan Cha, Sang-Eun Moon, Hye-Young Kim, In-Ho Cha, Kyung-Yeol Lee Source Type: journals

Is frozen section reliable in transoral CO2 laser-assisted cordectomies?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Endoscopic resection of laryngeal tumors is replacing external approaches. One drawback of endoscopic resection is the difficulty of interpretation of histological specimens because of thermal effect of laser on tissues. Our goal is to assess the reliability of frozen section in this setting by comparing its results with those of routine histology. We, retrospectively, reviewed the charts of all consecutive patients, who underwent cordectomies in our institution between January 2000 and 2008, using the CO2 laser Acublade system (Lumenis, Santa Clara, CA). Age, sex, staging of the tumor, previous tre...
Source: European Archives of Oto-Rhino-Laryngology - September 29, 2009 Category: ENT & OMF Tags: European Archives of Oto-Rhino-Laryngology Source Type: journals

[11C]Gefitinib ([11C]Iressa): Radiosynthesis, In Vitro Uptake, and In Vivo Imaging of Intact Murine FibrosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results demonstrated the promising potential of [11C]gefitinib to serve as a PET ligand for in vivo imaging of NFSa-bearing mice. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0265-5Authors Ming-Rong Zhang, National Institute of Radiological Sciences Department of Molecular Probes, Molecular Imaging Center 4-9-1 Anagawa, Inage-ku Chiba JapanKatsushi Kumata, National Institute of Radiological Sciences Department of Molecular Probes, Molecular Imaging Center 4-9-1 Anagawa, Inage-ku Chiba JapanAkiko Hatori, National Institute of Radiological Sciences Departmen...
Source: Molecular Imaging and Biology - September 29, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Identification and Characterization of Lutheran Blood Group Glycoprotein as a New Substrate of Membrane-type 1 Matrix Metalloproteinase 1 (MT1-MMP): A SYSTEMIC WHOLE CELL ANALYSIS OF MT1-MMP-ASSOCIATING PROTEINS IN A431 CELLS [Enzyme Catalysis and Regulation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Membrane-type 1 matrix metalloproteinase 1 (MT1-MMP) is a potent modulator of the pericellular microenvironment and regulates cellular functions in physiological and pathological settings in mammals. MT1-MMP mediates its biological effects through cleavage of specific substrate proteins. However, our knowledge of MT1-MMP substrates remains limited. To identify new substrates of MT1-MMP, we purified proteins associating with MT1-MMP in human epidermoid carcinoma A431 cells and analyzed them by mass spectrometry. We identified 163 proteins, including membrane proteins, cytoplasmic proteins, and functionally unknown proteins....
Source: Journal of Biological Chemistry - September 24, 2009 Category: Chemistry Authors: Niiya, D., Egawa, N., Sakamoto, T., Kikkawa, Y., Shinkawa, T., Isobe, T., Koshikawa, N., Seiki, M. Tags: Enzyme Catalysis and Regulation Source Type: journals

Reconstruction of the pulmonary artery for lung cancer: Long-term resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pulmonary artery reconstruction is safe, with excellent long-term survival. Our results support this technique as an effective option for patients with lung cancer. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - September 9, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Federico Venuta, Anna Maria Ciccone, Marco Anile, Mohsen Ibrahim, Tiziano De Giacomo, Giorgio F. Coloni, Erino A. Rendina Tags: General Thoracic Surgery Source Type: journals

[6]-Gingerol induces reactive oxygen species regulated mitochondrial cell death pathway in human epidermoid carcinoma A431 cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since skin cancer incidence and prevalence is constantly rising up the charts despite all efforts, search for newer, better agents for protection and treatment is required. Ginger (Zingiber officinale Roscoe), a monocotyledonous herb, is widely used as a herbal medicine, given the presence of homologous phenolic ketones, of which [6]-gingerol is the major one. The quantity of [6]-gingerol in the fresh ginger rhizome was found to be 104-965 microg/g in common varieties of ginger available in Indian market. Herein, [6]-gingerol was assessed for its anti-apoptotic effects in human epidermoid carcinoma A431 cells. [6]-Ging...
Source: Chemico-Biological Interactions - August 19, 2009 Category: Molecular Biology Authors: Nigam N, Bhui K, Prasad S, George J, Shukla Y Tags: Chem Biol Interact Source Type: journals

Immunohistochemical expression of ubiquitin and telomerase in cervical cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Ubiquitin and telomerase immunohistochemical expression patterns in cervical cancer were compared with normal cervical tissue samples. Eighty-one cervical cancer cases and 22 normal exo–endocervical tissue were examined with polyclonal antibody for ubiquitin and 44G12 clone for telomerase using tissue microarrays. The results were interpreted using a semiquantitative scale The average age of patients was 50.67 years. The most frequent histological types were moderately differentiated epidermoid carcinoma (43.5%), according to the degree of differentiation, and endocervical adenocarcinoma (42....
Source: Virchows Archiv - August 19, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Reproducibility of the kinetic analysis of 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography in mouse tumor modelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objectives: We assessed the reproducibility of the kinetic analysis of 3′-deoxy-3′-[18F]fluorothymidine (FLT) positron emission tomography (PET) in A431 human epidermoid carcinoma and murine Lewis lung carcinoma (LLC) tumor models.Methods: We injected 7.4 MBq of FLT (n=10 for each group) and acquired 2-h dynamic PET images. A second scan was performed 1 day later. We calculated standardized uptake value (SUV), kinetic rate constants, volume of distribution of phosphorylated FLT (Vdm), net influx constant (KFLT-CA) and influx constant by Patlak graphical analysis (KFLT-PA). The percent difference between measu...
Source: Nuclear Medicine and Biology - July 29, 2009 Category: Radiology Authors: Seung Jin Choi, Seog Young Kim, Su Jin Kim, Jae Sung Lee, Sang Ju Lee, Soo Ah Park, Seung Jin Lee, Sung-Cheol Yun, Ki Chun Im, Seung Jun Oh, Sang-We Kim, Jae Seung Kim, Jin Sook Ryu, Dae Hyuk Moon Source Type: journals

Bioactivity-Guided Isolation of Cytotoxic Sesquiterpenes and Flavonoids from Anthemis ruthenicaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1185942AbstractA new eudesmanolide sesquiterpene, sivasinolide 6--angelate (), was isolated from the aerial parts of together with the known compounds chrysanin (), tanacin (), 3-hydroxycostunolide (), centauridin (), and centaureidin (). The compounds were obtained by means of bioactivity-guided fractionation from the CHCl extract of the herb, which displayed high cytotoxic activity. The structures were determined by UV, HR‐ESI‐MS, and high-field 1D and 2D NMR spectral analyses, affording complete H- and C‐NMR assignments for all compounds. The cytotoxic activities of ...
Source: Planta Medica - July 29, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Up-regulation of the tight-junction protein ZO-1 by substance P and IGF-1 in A431 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The formation of a barrier by tight junctions is important in epithelia of various tissues. Substance P (SP) and insulin-like growth factor (IGF)-1 synergistically promote barrier function in the corneal epithelium. We have now examined the effects of SP and IGF-1 on expression of the tight-junction protein zonula occludens (ZO)-1 in A431 human epidermoid carcinoma cells. Reverse transcription-polymerase chain reaction (RT-PCR) and immunoblot analyses revealed that SP and IGF-1 increased the amounts of ZO-1 mRNA and protein in these cells in a concentration-dependent manner, with neither SP nor IGF-1 alone having such an e...
Source: Cell Biochemistry and Function - July 27, 2009 Category: Biochemistry Authors: Ji-Ae Ko, Shizuka Murata, Teruo Nishida Source Type: journals

Overexpression of DPAGT1 Leads to Aberrant N-Glycosylation of E-Cadherin and Cellular Discohesion in Oral CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cancer cells are frequently characterized by aberrant increases in protein N-glycosylation and by disruption of E-cadherin–mediated adherens junctions. The relationship between altered N-glycosylation and loss of E-cadherin adhesion in cancer, however, remains unclear. Previously, we reported that complex N-glycans on the extracellular domains of E-cadherin inhibited the formation of mature adherens junctions. Here, we examined whether dysregulated N-glycosylation was one of the underlying causes for cellular discohesion in oral cancer. We show that dense cultures of human salivary epidermoid carcinoma A253 cells exh...
Source: Cancer Research - July 14, 2009 Category: Cancer & Oncology Authors: Nita-Lazar, M., Noonan, V., Rebustini, I., Walker, J., Menko, A. S., Kukuruzinska, M. A. Tags: Cell, Tumor, and Stem Cell Biology Source Type: journals

Pyripyropenes, Fungal Sesquiterpenes Conjugated with alpha-Pyrone and Pyridine Moieties, Exhibits Anti-angiogenic Activity against Human Umbilical Vein Endothelial Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the course of our search for anti-angiogenic substances, pyripyropenes A (1), B (2), and D (3) were re-discovered as selective anti-proliferative substances against human umbilical vein endothelial cells (HUVECs) from a marine-derived fungus of Aspergillus sp. Pyripyropenes showed potent anti-proliferative activity against HUVECs with IC(50) values of the range of 0.1-1.8 muM, which were cytostatic at 0.05 to 20 muM. The selective index was more than 55-fold in comparison with those of several tumor cell lines. Compound 1 inhibited vascular endothelial growth factor (VEGF)-induced migration and tubular formation of ...
Source: Biological and Pharmaceutical Bulletin - June 30, 2009 Category: Drugs & Pharmacology Authors: Hayashi A, Arai M, Fujita M, Kobayashi M Tags: Biol Pharm Bull Source Type: journals

Inhibition of 12-LOX and COX-2 reduces the proliferation of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-Akt signalling pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Please cite this paper as: Inhibition of 12-LOX and COX-2 reduces the proliferation of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-Akt signalling pathways. Experimental Dermatology 2009.Abstract: Eicosanoids, the oxygenated metabolites of arachidonic acid (AA), mediate a variety of human diseases, such as cancer, inflammation and arthritis. To evaluate the role of eicosanoids in epidermoid carcinoma, the expression of AA metabolizing enzymes, such as lipoxygenases (LOXs) and cyclooxygenases (COXs), was analysed in a human epidermoid carcinoma cell line (A431). These studies revealed overexpressio...
Source: Experimental Dermatology - June 23, 2009 Category: Dermatology Authors: Smita Agarwal, Chandrani Achari, D. Praveen, Karnati R. Roy, Gorla Venkateswara Reddy, Pallu Reddanna Source Type: journals

Metastatic Liposarcoma to the ParotidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an exceptional case of parotid metastasis of myxoid liposarcoma in a 42-year-old man and insist on the worse prognosis of this entity. (Source: Journal of Oncology)
Source: Journal of Oncology - June 9, 2009 Category: Cancer & Oncology Source Type: journals

A dramatic case of genital radionecrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Background Epidermoid carcinoma of the penis presents in 1% of malignant tumors in men. Penis cancer treatment has traditionally been total or partial amputation. There are authors who consider radiation to be part of penis cancer treatment in select cases—especially the use of brachytherapy and external radiation. Clinical case The case of a 48-year-old male who in 2004 presented with an ulcerated lesion of the penis that was left unattended to is presented. Two years later, he sought medical attention and physical examination revealed an ulcerated penile lesion with poorly def...
Source: International Urology and Nephrology - May 31, 2009 Category: Urology & Nephrology Tags: International Urology and Nephrology Source Type: journals

Anal Squamous Cell Carcinoma in the HIV-Positive PatientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article describes the disease process and current treatment options.[...]© Thieme Medical PublishersGet connected:Table of contents | Abstract | Full text (Source: Clinics in Colon and Rectal Surgery)
Source: Clinics in Colon and Rectal Surgery - May 28, 2009 Category: Surgery Source Type: journals

Malignant tumours development in peri-implant tissues in oncologic and non-oncologic patients: a report of two casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases of squamous cell carcinoma arising in peri-implant tissues after dental implant placement. A 35-year-old woman was referred to us one month after prosthetic rehabilitation following insertion of an implant in the area 36 four months earlier. She presented with a peri-implant tissue lesion with appearance of inflammatory tissue. Its biopsy was reported as infiltrate epidermoid carcinoma. Second case is a 75-year-old male with resection of epidermoid carcinoma affecting the lower left gingiva and mandible and reconstruction with iliac crest free flap fourteen years ago. Further fixed rehabilitation with o...
Source: International Journal of Oral and Maxillofacial Surgery - May 1, 2009 Category: ENT & OMF Authors: S. Ramírez-Varela, J. Acero-Sanz, V. De Paz-Hermoso, J. López-De Atalaya, S. Ochandiano-Caicoya, C. Navarro-Vila Tags: Oral Presentations Source Type: journals

A new acyclic diterpene acid and bioactive compounds from Knema glauca.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Investigation of the chemical constituents of the fruits of Knema glauca (Myristicaceae) yielded a new acyclic diterpene acid, named glaucaic acid 4, together with four acylphenols, including 1-(2,6-dihydroxyphenyl) tetradecan-1-one 1, malabaricone A 6, dodecanoylphloroglucinol 7 and 1-(2,4,6-trihydroxyphenyl)-9-phenylnonan-1-one 8, two lignans sesamin 2 and asarinin 3, and a flavan, myristinin D 5. In addition, myristinin A 9 and (+/-)-7,4'-dihydroxy-3'-methoxyflavan 10 were isolated from its leaves and stems, respectively. When tested against small-cell lung cancer (NCI-H187), epidermoid carcinoma (KB) and breast can...
Source: Archives of Pharmacal Research - April 30, 2009 Category: Drugs & Pharmacology Authors: Rangkaew N, Suttisri R, Moriyasu M, Kawanishi K Tags: Arch Pharm Res Source Type: journals

Bee Propolis Stops Tumors from Neurofibromatosis and CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) Honeybees are some of the most amazing creatures ever created by nature. They play a vital role in much of the food supply through pollination, and they provide people with a healthy natural alternative to sugar. Some of the most interesting aspects of bees are the substances they make to use themselves. Propolis is a natural resin found in young tree buds. Bees collect it for use as a glue to seal their homes. Propolis is an exceedingly complex product that contains substances that prevent and treat diseases ranging from cancer to the common cold. Recent research has documented the ability of propolis to sup...
Source: NaturalNews.com - April 29, 2009 Category: Consumer Health Advice Source Type: news

[Carcinoma of the lips.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epidermoid carcinoma, that is, squamous cell carcinoma of the skin, is the most common malignant tumor of the lips. It occurs especially in men. Its primary causes are sun exposure, smoking, and chronic irritation. Leukoplakia is the most frequent precancerous lesion. Epidermoid carcinoma may appear clinically as a scaly erosion or an ulceration. Standard treatment is surgical excision with reconstruction. PMID: 19361830 [PubMed - as supplied by publisher] (Source: Revue de Stomatologie et de Chirurgie Maxillo-Faciale)
Source: Revue de Stomatologie et de Chirurgie Maxillo-Faciale - April 7, 2009 Category: ENT & OMF Authors: Ben Slama L Tags: Rev Stomatol Chir Maxillofac Source Type: journals

Two New Sesquiterpenoids from Solanum lyratum with Cytotoxic Activities.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two new sesquiterpenoids, lyratol C (1) and lyratol D (2), together with two known sesquiterpenoids, dehydrovomifoliol (3) and blumenol A (4), were isolated from the whole plant of Solanum lyratum. Their structures were established by spectroscopic analyses. In vitro, the four compounds showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC(50) values in the range 3.7-8.1 muM. PMID: 19336938 [PubMed - in process] (Source: Chemical and Pharmaceutical Bulletin)
Source: Chemical and Pharmaceutical Bulletin - April 1, 2009 Category: Drugs & Pharmacology Authors: Ren Y, Shen L, Zhang DW, Dai SJ Tags: Chem Pharm Bull (Tokyo) Source Type: journals

Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: In vitro and in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the anti-angiogenic effects of Ganoderma tsugae methanol extract (GTME) on human epidermoid carcinoma A-431 cells. Our data indicate that GTME inhibits the expression of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) in vitro and in vivo, and also inhibits the capillary tube formation of human umbilical vein endothelial cells (HUVECs). We also show that the suppression of VEGF expression by GTME can be restored by treatment with EGF. These results suggest that GTME inhibits VEGF expression via the suppression of EGFR expression, resulting in the downregulation of VEGF secr...
Source: Cancer Letters - March 28, 2009 Category: Cancer & Oncology Authors: Hsu SC, Ou CC, Chuang TC, Li JW, Lee YJ, Wang V, Liu JY, Chen CS, Lin SC, Kao MC Tags: Cancer Lett Source Type: journals

Molecular Imaging and Quantitative Measurement of Epidermal Growth Factor Receptor Expression in Live Cancer Cells Using Immunolabeled Gold NanoparticlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION. Immunolabeled nanoparticles can quantify receptor expression with performance comparable to fluorescence markers and show promise to better characterize receptor expression via their refractive index sensitivity. (Source: American Journal of Roentgenology)
Source: American Journal of Roentgenology - March 19, 2009 Category: Radiology Authors: Crow, M. J., Grant, G., Provenzale, J. M., Wax, A. Tags: Nuclear Medicine and Molecular Imaging Source Type: journals

Identification and characterization of a novel CXC chemokine in xenograft tumor induced by mas-overexpressing cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Overexpressions of G protein-coupled receptor (GPCR) with elevated downstream signaling events have been reported in various tumors. However, the cellular mechanism that GPCR overexpression leads to tumor formation is largely unknown. The orphan GPCR mas was originally isolated from a human epidermoid carcinoma. In vivo studies of mas-overexpressing cells suggested that xenograft tumor formation was positively correlated with the levels of mas expression. Histochemical analysis indicated that xenograft tumor consisted of mas-transfected and stromal cells. Biochemical analyses revealed that cells overexpressing mas exhibite...
Source: International Journal of Cancer - March 19, 2009 Category: Cancer & Oncology Authors: Wen-Zhen Lin, Zhou-Fang Li, Sup-Yin Tsang, Lydia K.W. Lung, Da-Kui Wang, Wood-Yee Chan, You-Kai Zhu, Susanna S.T. Lee, Wing-Tai Cheung Source Type: journals

A rare case of invasive vaginal carcinoma associated with vaginal prolapseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Careful preoperative histological evaluation of cervix in cases of uterine prolapse and postoperative cytologic and colposcopic follow-up of the vagina after hysterectomies are important because possible association with cervical carcinoma and occurrence of late vaginal cancer. Surgery and radiotherapy were effectively combined in this case that remains with no recurrence after 2 years follow-up. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1016-1Authors Thales Paulo Batista, University of Pernambuco Centro de Oncologia, Hospital Universitário Oswaldo Cruz ...
Source: Archives of Gynecology and Obstetrics - March 5, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Radiotherapy for Epidermoid Carcinoma of the Anus: Thirty Years' ExperienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results have confirmed that CRT is an effective approach. Patients with human immunodeficiency virus can be treated with CRT. Tumor mobility significantly predicts the outcome; the implications for management are discussed. We also discuss the treatment planning implications of the late morbidity findings. The substantial incidence of additional malignancies underscores the importance of full oncologic screening during follow-up. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 2, 2009 Category: Radiology Authors: Robert J. Myerson, Elesyia D. Outlaw, Albert Chang, Elisa H. Birnbaum, James W. Fleshman, Perry W. Grigsby, Ira J. Kodner, Robert S. Malayapa, Matthew G. Mutch, Parag Parikh, Joel Picus, Benjamin R. Tan Tags: Anus Source Type: journals

Sarcophine-diol, a Chemopreventive Agent of Skin Cancer, Inhibits Cell Growth and Induces Apoptosis through Extrinsic Pathway in Human Epidermoid Carcinoma A431 Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sarcophine-diol (SD), a structural modifications of sarcophine, has shown chemopreventive effects on 7,12-dimethylbenz(a)anthracene-initiated and 12-O-tetradecanoylphorbol-13-acetate-promoted skin tumor developments in mice. Tumorigenesis is associated with uncontrolled cell growth and loss of apoptosis. In the present study, the effects of SD on cell growth and apoptosis in human epidermoid carcinoma A431 cells were determined to assess whether SD could inhibit cell growth and/or induce apoptosis, thus elucidating possible mechanism of action. MTT assay was used for cell viability; bromodeoxyuridine incorporation assa...
Source: Translational Oncology - March 1, 2009 Category: Cancer & Oncology Authors: Zhang X, Bommareddy A, Chen W, Khalifa S, Kaushik RS, Fahmy H, Dwivedi C Tags: Transl Oncol Source Type: journals

[Tumoral pathology of salivary glands. Our experience]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We have found two main differences with previously reported studies: the elevated mean age of patients with malignant tumours and, probably as a result of this advanced age, the high incidence of squamous cell carcinoma due to metastatic dissemination of skin cancers. PMID: 19401079 [PubMed - in process] (Source: Acta Otorrinolaringologica Espanola)
Source: Acta Otorrinolaringologica Espanola - March 1, 2009 Category: ENT & OMF Authors: Lahoz Zamarro MT, Galve Royo A, Galve Royo F Tags: Acta Otorrinolaringol Esp Source Type: journals

[Adult Schönlein-Henoch purpura associated with epidermoid carcinoma of the lung.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The neoplasm could be responsible of the development of the Schönlein-Henoch purpura. The discovery of this systemic vasculitis in an elderly patient should warrant a deep screening for an occult neoplasm. PMID: 19217841 [PubMed - as supplied by publisher] (Source: Nephrologie & Therapeutique)
Source: Nephrologie & Therapeutique - February 12, 2009 Category: Urology & Nephrology Authors: Frigui M, Kechaou M, Ben Hmida M, Khanfir A, Frikha M, Hachicha J, Bahloul Z Tags: Nephrol Ther Source Type: journals

[Isolated mandibular B-cell lymphoma revealed by inferior alveolar nerve anesthesia.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DISCUSSION: Our observation is unusual in its clinical presentation. Mandibular lymphomas most often present as a painless swelling, sometimes ulcerated in the mouth. They are very rarely diagnosed after an isolated hypoesthesia of V3. Lymphomas are the second most frequent head and neck lymphomas after epidermoid carcinomas, but the frequency seems to be increasing. In almost all the cases, they present as B-cell tumours of the DLBCL subtype in the WHO classification. Mandibular localizations account for only 0.6% of the cases. They are often misdiagnosed as a dental problem. The complete remission rate after chemotherapy...
Source: Revue de Stomatologie et de Chirurgie Maxillo-Faciale - February 2, 2009 Category: ENT & OMF Authors: Trost O, Charon-Barra C, Soichot P, Moreau G, Trouilloud P, Malka G Tags: Rev Stomatol Chir Maxillofac Source Type: journals

Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part IIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The antiproliferative activities of aqueous and organic extracts prepared from 26 Hungarian species of the tribes Cynereae and Lactuceae (Asteraceae) were tested in vitro against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells by using the MTT assay. Of the tested 200 extracts of different plant parts obtained with n-hexane, chloroform, 50% methanol and water, 16 extracts displayed noteworthy cell growth inhibitory activity (>50% inhibition at a concentration of 10 µg/mL). The IC50 values of these extracts were determined, and their direct cytotox...
Source: Phytotherapy Research - January 23, 2009 Category: Biochemistry Authors: Boglárka Csupor-Löffler, Zsuzsanna Hajdú, Borbála Réthy, István Zupkó, Imre Máthé, Tamás Rédei, George Falkay, Judit Hohmann Source Type: journals

The histopathological typing of 48 cases of ESO-phageal adenocarcinoma and its tissue originEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Of 2487 cases of esophageal carcinoma pathologically confirmed after resection in 1978–1988 in Shantou, adenocarcinoma accounted for 1.93% (48 cases). These were divided into 6 types; Ordinary well - differentiated adenocarcinoma, 10 cases; Ordinary poorly - differentiated adenocarcinoma, 11 cases; Adeno - squamous carcinoma, 18 cases; Muco - epidermoid carcinoma, 4 cases; “Basal Cell - Like Carcinoma”, 4 cases; Cylindroma - Like carcinoma, 1 case. Mucohistochemistry and immuno-histochemistry studies revealed some differences among these types; And their prognosis also varied. The tissue origi...
Source: Chinese Journal of Cancer Research - January 3, 2009 Category: Cancer & Oncology Tags: Chinese Journal of Cancer Research Source Type: journals

[Institutional report - Thoracic general] Sixty tracheal resections - single center experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluates the clinical outcome following surgery of our patients for the last seven years. Between 2001 and 2008 we performed tracheal resections in 60 patients. There were 46 cases of postintubation stenosis and 14 tumors. The range of resected rings was 1–8. The maximal resection length performed in our series (4 cm) was achieved using only basic releasing maneuvers such as anterior dissection of the trachea and cervical flexion. Emergency tracheal resection with no complications was performed in 12 patients who presented with severe dyspnea due to very tight stenosis. One patient died during the su...
Source: Interactive CardioVascular and Thoracic Surgery - January 2, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Cordos, I., Bolca, C., Paleru, C., Posea, R., Stoica, R. Tags: Institutional report - Thoracic general Source Type: journals

Effects of Panduratin A Isolated from Kaempferia pandurata ROXB. on the Expression of Matrix Metalloproteinase-9 by Porphyromonas gingivalis Supernatant-Induced KB Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, panduratin A, a natural bioactive compound isolated from Kaempferia pandurata ROXB., was used to test its in vitro inhibitory activity against MMP-9 secretion from Porphyromonas gingivalis supernatant-induced human oral epidermoid carcinoma KB cells. Gelatin zymography, Western blot and RT-PCR analyses were performed to evaluate MMP-9 expression. The gelatin zymograms revealed that the main gelatinase secreted by P. gingivalis supernatant-induced KB cells migrated at 92 kDa, representing MMP-9. MMP-9 protein and mRNA levels were significantly decreased after panduratin A treatment (p<0.05). In contrast, p...
Source: Biological and Pharmaceutical Bulletin - January 1, 2009 Category: Drugs & Pharmacology Authors: Yanti , Oh HI, Anggakusuma , Hwang JK Tags: Biol Pharm Bull Source Type: journals

Metastatic Liposarcoma to the ParotidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an exceptional case of parotid metastasis of myxoid liposarcoma in a 42-year-old man and insist on the worse prognosis of this entity. (Source: Journal of Oncology)
Source: Journal of Oncology - December 15, 2008 Category: Cancer & Oncology Source Type: journals

Discovering novel 3-nitroquinolines as a new class of anticancer agents1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study was the first to identify new structural types of antiproliferative agents against the EGFR-overexpressing tumor cell lines by the incorporation of the nitro group at the 3-position of the quinoline core structure, providing promising new templates for the further development of anticancer agents. (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 14, 2008 Category: Drugs & Pharmacology Authors: Hai-hong LI, He HUANG, Xiu-hua ZHANG, Xiao-min LUO, Li-ping LIN, Hua-liang JIANG, Jian DING, Kaixian CHEN, Hong LIU Tags: ORIGINAL ARTICLES Source Type: journals

Photodynamie activity on human larynx epidermoid carcinoma cell line, HEp-2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Research ReportsDOI 10.1007/BF02999864Authors S. Ganesan, Anna University Department of Physics 600 025 Madras IndiaV. Masitamani, Anna University Department of Physics 600 025 Madras India Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 Journal Volume Volume 11 Journal Issue Volume 11, Numbers 3-4 / September, 1994 (Source: Medical Oncology)
Source: Medical Oncology - December 5, 2008 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Radiation-induced carcinoma of the rectumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of carcinoma of the rectum arising as two separate primaries 46 years after irradiation for an epidermoid carcinoma of the cervix. There were many pathologic changes related to the radiation therapy. Content Type Journal ArticleDOI 10.1007/BF02989000Authors Antonio Martins, Memorial Sloan-Kettering Cancer Center 1275 York Avenue 10021 New York New YorkStephen S. Sternberg, Memorial Sloan-Kettering Cancer Center 1275 York Avenue 10021 New York New YorkFadi F. Attiyeh, Memorial Sloan-Kettering Cancer Center 1275 York Avenue 10021 New York New York Journal Diseases of the Colon & RectumOnline I...
Source: Diseases of the Colon & Rectum - November 28, 2008 Category: Gastroenterology Tags: Diseases of the Colon & Rectum Source Type: journals

Discovering novel 3-nitroquinolines as a new class of anticancer agents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study was the first to identify new structural types of antiproliferative agents against the EGFR-overexpressing tumor cell lines by the incorporation of the nitro group at the 3-position of the quinoline core structure, providing promising new templates for the further development of anticancer agents. PMID: 19026174 [PubMed - in process] (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - November 27, 2008 Category: Drugs & Pharmacology Authors: Li HH, Huang H, Zhang XH, Luo XM, Lin LP, Jiang HL, Ding J, Chen KX, Liu H Tags: Acta Pharmacol Sin Source Type: journals

Enediyne lidamycin enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitor, gefitinib, in epidermoid carcinoma A431 cells and lung carcinoma H460 cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 41DOI: 10.1097/CAD.0b013e328318292cAuthors: Liu, Hong; Li, Liang; Li, Xing-Qi; Liu, Xiu-Jun; Zhen, Yong-Su (Source: Anti-Cancer Drugs)
Source: Anti-Cancer Drugs - November 21, 2008 Category: Cancer & Oncology Tags: Abstract HTML PDF (407 K) Source Type: journals

[Tumors of the oral cavity: the usefulness of dynamic CT.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The habitual contact between the mucosal surfaces of the oral cavity makes some clinically obvious lesions difficult to identify at CT. The interposition of air acts as a natural contrast, separating the gums from the mucosa of the buccomaseteric region; PCCT provides relevant information and should be included in the imaging workup in patients with tumors of the oral cavity. PMID: 19100214 [PubMed - in process] (Source: Radiologia)
Source: Radiologia - November 1, 2008 Category: Radiology Authors: Crespo Martínez C, Navarro Navarro M, Castro Copete MC, Carnero Ruiz M, Lorente Fernández MF, Calbo Maiques J Tags: Radiologia Source Type: journals

[Tumors of the oral cavity: the usefulness of dynamic CT]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The habitual contact between the mucosal surfaces of the oral cavity makes some clinically obvious lesions difficult to identify at CT. The interposition of air acts as a natural contrast, separating the gums from the mucosa of the buccomaseteric region; PCCT provides relevant information and should be included in the imaging workup in patients with tumors of the oral cavity. PMID: 19100214 [PubMed - in process] (Source: Radiologia)
Source: Radiologia - November 1, 2008 Category: Radiology Authors: Crespo Martínez C, Navarro Navarro M, Castro Copete MC, Carnero Ruiz M, Lorente Fernández MF, Calbo Maiques J Tags: Radiologia Source Type: journals

Metachronous bilateral mucoepidermoid carcinoma of the parotid glandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a very rare case of bilateral muco-epidermoid carcinoma of the parotid gland that underwent bilateral parotidectomy with neck dissections and radiotherapy. This case has done well for three years and suggests that metachronous bilateral mucoepidermoid carcinoma of the parotid gland, if treated as per the merits of each side, has a reasonable survival. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12070-008-0086-xAuthors John C. Muthusami, Christian Medical College Hospital Vellore 632 004 Tamil Nadu IndiaPranay Gaikwad, Christian Medical College Hospital Vellore 632 004 Tamil Nadu IndiaJohn ...
Source: Indian Journal of Otolaryngology and Head & Neck Surgery - October 22, 2008 Category: ENT & OMF Tags: Indian Journal of Otolaryngology and Head & Neck Surgery Source Type: journals

G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: Differential trafficking and distribution.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A-kinase Anchoring Proteins (AKAPs) define an expanding group of scaffold proteins that display a signature binding site for the RI/RII subunit of protein kinase A. AKAP5 and AKAP12 are multivalent (with respect to protein kinases and phosphatases) and display the ability to associate with the prototypic member of G protein-coupled receptors, the beta(2)-adrenergic receptor. We probed the relative abundance, subcellular distribution and localization of AKAP5 and AKAP12 in human embryonic kidney HEK293 and epidermoid carcinoma A431 cells. HEK293 cells are relatively rich in AKAP5 (found mostly in association with the ce...
Source: Cellular Signalling - October 10, 2008 Category: Cytology Authors: Chen MH, Malbon CC Tags: Cell Signal Source Type: journals

[Scintigraphy in staging upper aerodigestive tract epidermoid carcinomas.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The incidence of bone metastases in the initial extension assessment was low; consequently, they are not sought systematically. However, their presence radically changes the prognosis and the therapeutic management, raising the question of screening. The technetium-99m bone scintigraphy has limits, with many false-positive resulting the need for additional investigations. Defining the risk factors for bone metastases would improve screening. Two questions remain: what factors are involved? The bone pain and the hypercalcemia must be analyzed with a larger number of cases, but they seem to be nonspecific. The no...
Source: Annales d'Oto-laryngologie et de Chirurgie Cervico Faciale - September 11, 2008 Category: ENT & OMF Authors: Ayache S, Tramier B, Moullard V, Michel L, Strunski V Tags: Ann Otolaryngol Chir Cervicofac Source Type: journals

[Double simultaneous fingertip metastasis of an epidermoid carcinoma. A case report.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fingertip metastases are rare. The authors report the case of a patient with an epidermoid carcinoma of the larynx who presented with two separate finger pulp metastases in each hand. According to the literature this seems a very unusual occurrence. This diagnosis must be considered in the differential diagnosis of every suspicious fingertip lesion. PMID: 18818116 [PubMed - as supplied by publisher] (Source: Chirurgie de la Main)
Source: Chirurgie de la Main - September 4, 2008 Category: Surgery Authors: Ottomani S, Levadoux M, Cathelineau O, Nguyen M, Monchal T Tags: Chir Main Source Type: journals

Reversal effect of resveratrol on multidrug resistance in KBv200 cell line.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A multidrug-resistant clone of human oral epidermoid carcinoma KB cells was isolated by stepwise selection on exposure to increasing doses of vincristine. The final clone, KBv200, obtained after ethylmethane sulfonate mutagenesis showed 156-fold higher resistance to vincristine than KB cells. The cells were also cross-resistant to paclitaxel and adriamycin. The aim of this study was to explore the reversal effect and potential mechanism of resveratrol on KBv200 cells. MTT assay was used to investigate the reversal index of resveratrol to vincristine, adriamycin and paclitaxel. Cell apoptosis was measured by flow cytome...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - August 28, 2008 Category: Drugs & Pharmacology Authors: Quan F, Pan C, Ma Q, Zhang S, Yan L Tags: Biomed Pharmacother Source Type: journals