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We need better randomized comparison trials of prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
More than 50 years after the first randomized oncology trial, the number of randomized trials comparing differing primary treatments for prostate cancer is disappointing. One of these rare, randomized primary treatment comparisons appears in this edition of Cancer, and the investigators are to be congratulated for their efforts comparing cryotherapy with external beam radiotherapy. (Source: Cancer)
Source: Cancer - November 18, 2009 Category: Cancer & Oncology Authors: W. Robert Lee Source Type: journals

Salvage high-intensity focused ultrasound for biopsy-confirmed local recurrence of prostate cancer after radical prostatectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To present experience in high-intensity focused ultrasound (HIFU) used as a salvage therapy for biopsy-confirmed local recurrence at the vesico-urethral anastomosis after radical prostatectomy (RP). From July 2006, four patients diagnosed with prostate cancer recurrence after RP were treated with HIFU, with or without salvage radiotherapy, using the Sonablate® 500 (Focus Surgery, IN, USA). Biochemical failure was defined as in increase in prostate-specific antigen (PSA) level of >0.2 ng/mL. No patients received any adjuvant therapy after HIFU therapy before reporting failure. The mean age and initial PSA level before RP w...
Source: BJU International - November 17, 2009 Category: Urology & Nephrology Authors: Akiko Murota-Kawano, Mayura Nakano, Sachiko Hongo, Sunao Shoji, Yoshihiro Nagata, Toyoaki Uchida Source Type: journals

Survival and relapse pattern after trimodality therapy for malignant pleural mesotheliomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Trimodality therapy showed a survival benefit in patients with stage III or lower malignant pleural mesothelioma. Most of the recurrences were local. Therefore, better local control is required to improve the prognosis of the disease. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11748-009-0440-2Authors Kenichi Okubo, Kyoto University Hospital Department of Thoracic Surgery 54 Kawahara-cho, Shogoin, Sakyo-ku Kyoto 606-8507 JapanMakoto Sonobe, Kyoto University Hospital Department of Thoracic Surgery 54 Kawahara-cho, Shogoin, Sakyo-ku Kyoto 606-8507 JapanTakuji Fujinaga, Ky...
Source: General Thoracic and Cardiovascular Surgery - November 11, 2009 Category: Cardiovascular & Thoracic Surgery Tags: General Thoracic and Cardiovascular Surgery Source Type: journals

Trilateral retinoblastoma: Potentially curable with intensive chemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a series of 13 patients treated with intensive chemotherapy, defined as the intention to include high-dose chemotherapy with autologous hematopoietic stem cell rescue.Induction chemotherapy generally included vincristine, cisplatin or carboplatin, cyclophosphamide, and etoposide. Hematopoietic stem cells typically were harvested after the first or second cycle of induction chemotherapy, usually from peripheral blood. High-dose chemotherapy regimens were thiotepa-based (n = 7) or melphalan and cyclophosphamide (n = 3).Trilateral sites were pineal (n = 11) and suprasellar (n = 2); 7 patients had localized (M-0) d...
Source: Pediatric Blood and Cancer - November 11, 2009 Category: Cancer & Oncology Authors: Ira J. Dunkel, Rima F. Jubran, Sri Gururangan, Guillermo L. Chantada, Jonathan L. Finlay, Stewart Goldman, Yasmin Khakoo, Joan M. O'Brien, Manuela Orjuela, Carlos Rodriguez-Galindo, Mark M. Souweidane, David H. Abramson Source Type: journals

Acute Toxicity after Single Fraction High Dose Rate Brachytherapy with External Beam Radiotherapy in Intermediate and High Risk Prostate CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report our experience of a single HDR fraction. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: N. Alam, C. Taylor, P. Mandall, L. James, J. Logue, J. Wylie Tags: Abstracts Source Type: journals

Dose Escalated Radiotherapy in the Treatment of Locally Advanced Prostate Cancer using High Dose Rate Brachytherapy in Combination with Whole Pelvic Radiotherapy: a Single Centre ExperienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the outcome of dose escalation treatment using high dose rate brachytherapy in combination with whole pelvic external beam radiotherapy in the treatment of locally advanced prostate cancer, in our centre. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: D. Muthu Kumar, A. Arora, L. Speed, R. Vijayuan, P. Hoskin Tags: Abstracts Source Type: journals

Long Term Follow-up of Patients Receiving High Dose Rate (HDR) Brachytherapy Boost in Combination with External Beam Radiotherapy Treatment (EBRT) for High Risk Prostate Cancer: Relapse Rate and ToxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim/introduction: Prostate cancer is the most commonly diagnosed male cancer in the UK; one third of all new cases present with locally advanced disease. At UCLH, high risk patients deemed to benefit from dose escalation have been treated with combined EBRT and HDR brachytherapy boost since 2000. We revisited 32 of these patients to assess late bowel and bladder toxicity, survival, biochemical relapse and metastatic disease rates. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: A. Swampillai, R. Lewis, H. Payne Tags: Abstracts Source Type: journals

Pattern of Relapse after Fractionated External Beam Radiotherapy for Meningioma: Experience from Addenbrooke's HospitalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our cohort of patients had an overall local control and survival similar to those documented from other departments. Grade was an important prognostic factor. Patients treated with >50Gy had worse local control outcomes, probably due to selection bias. Dose escalation may still be appropriate for high-risk disease, and may be more effective with more conformal techniques, such as intensity-modulated radiotherapy. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: V. Estall, S.J. Treece, R. Jena, S.J. Jefferies, K.E. Burton, R.A. Parker, N.G. Burnet Tags: Original Articles Source Type: journals

Impact of the Target Volume (Prostate Alone vs. Prostate with Seminal Vesicles) and Fraction Dose (1.8 Gy vs. 2.0 Gy) on Quality of Life Changes After External-Beam Radiotherapy for Prostate CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The risk of adverse QoL changes after EBRT for prostate cancer cannot be derived from the dose-volume histogram alone. Seminal vesicles can be included in the CTV up to a moderate total dose without adverse effects on QoL. Apart from a longer recovery period, higher fraction doses were not associated with higher toxicity. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00066-009-2008-6Authors Michael Pinkawa, RWTH Aachen Department of Radiotherapy Aachen GermanyMarc D Piroth, RWTH Aachen Department of Radiotherapy Aachen GermanyKarin Fischedick, RWTH Aachen Department o...
Source: Strahlentherapie und Onkologie - November 9, 2009 Category: Cancer & Oncology Tags: Strahlentherapie und Onkologie Source Type: journals

A Dosimetric Selectivity Intercomparison of HDR Brachytherapy, IMRT and Helical Tomotherapy in Prostate Cancer RadiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HDR-BT offers better conformality in comparison with HT and IMRT and reduces the volume of healthy tissue receiving a low dose. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00066-009-2009-5Authors Johanne Hermesse, Liège University Hospital Department of Radiation Oncology Liège BelgiumSylvie Biver, Liège University Hospital Department of Radiation Oncology Liège BelgiumNicolas Jansen, Liège University Hospital Department of Radiation Oncology Liège BelgiumEric Lenaerts, Liège University Hospital Department of Medical Physics Liège BelgiumNathalie De Patoul, S...
Source: Strahlentherapie und Onkologie - November 9, 2009 Category: Cancer & Oncology Tags: Strahlentherapie und Onkologie Source Type: journals

A Randomized Trial Comparing Hypofractionated and Conventionally Fractionated Three-Dimensional External-Beam Radiotherapy for Localized Prostate AdenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this first evaluation, the HFRT schedule is feasible and induces acceptable or even lower acute toxicity compared with the toxicities in the CFRT schedule. Extended follow-up is needed to justify this fractionation schedule’s safety in the long term. Content Type Journal ArticleCategory Current DiscussionDOI 10.1007/s00066-009-1982-zAuthors Darius Norkus, Institute of Oncology, Vilnius University Department of Radiotherapy Vilnius LithuaniaAlbert Miller, Institute of Oncology, Vilnius University Department of Radiotherapy Vilnius LithuaniaJuozas Kurtinaitis, Institute of Oncology, V...
Source: Strahlentherapie und Onkologie - November 9, 2009 Category: Cancer & Oncology Tags: Strahlentherapie und Onkologie Source Type: journals

Comment by J. Schäfer, G. Welzel, F. Wenz on D. Norkus et al. A Randomized Trial Comparing Hypofractionated and Conventionally Fractionated Three-Dimensional External-Beam Radiotherapy for Localized Prostate Adenocarcinoma. A Report on Acute ToxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory CommentDOI 10.1007/s00066-009-9982-6Authors Frederik Wenz, Universitätsmedizin Mannheim, Universität Heidelberg Theodor Klinik für Strahlentherapie und Radioonkologie Kutzer Ufer 1–3 68167 Mannheim Germany Journal Strahlentherapie und OnkologieOnline ISSN 1439-099XPrint ISSN 0179-7158 Journal Volume Volume 185 Journal Issue Volume 185, Number 11 / November, 2009 (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 9, 2009 Category: Cancer & Oncology Tags: Strahlentherapie und Onkologie Source Type: journals

Mesothelioma Trimodality Therapy Benefits PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a study recently published in The Annals of Thoracic Surgery, mesothelioma researchers found a trimodality therapeutic approach of chemotherapy, surgery and radiation to be effective in treating malignant pleural mesothelioma. Mesothelioma is a cancer caused almost exclusively by asbestos exposure. A long latency period of 20 to 50 years complicates the diagnostic process and usually leads to a diagnosis at a late stage of cancer development. Because most cases of malignant mesothelioma are diagnosed in a late stage of development, treatment options are often limited to palliative measures intended to improve quality of...
Source: Asbestos and Mesothelioma News - November 5, 2009 Category: Environmental Health Authors: mwhitmer Tags: Asbestos Exposure Mesothelioma Mesothelioma Research Mesothelioma Treatment Malignant Mesothelioma Malignant Pleural Mesothelioma Mesothelioma Cancer Source Type: news

Fractionated radiosurgical management of intramedullary spinal cord metastasis: A case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Fractionated stereotactic radiosurgery is a feasible, safe, and effective modality for the treatment of ICSM and should be carefully considered in the management of this difficult to treat condition. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Simul Parikh, Dwight E. Heron Tags: Case reports Source Type: journals

Association of age and response to androgen-deprivation therapy with or without radiotherapy for prostate cancer: data from CaPSUREEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess whether the response to primary androgen-deprivation therapy (PADT) and radiotherapy (RT) plus adjuvant ADT would be muted in older men, as their tumours might already be relatively androgen insensitive, because serum testosterone levels decline with increasing age. Using the Cancer of the Prostate Strategic Urologic Research Endeavor database, we conducted an observational study evaluating two groups of men treated for prostate cancer from 1995 to 2006. One group of 1748 men was treated with PADT and the second group of 612 men was treated with RT (external beam RT or brachytherapy) with neoadjuvant and/or adjuv...
Source: BJU International - November 4, 2009 Category: Urology & Nephrology Authors: David Aaronson, Janet Cowan, Peter Carroll, Badrinath Konety Source Type: journals

Primary therapy for early-stage cervical cancer: radical hysterectomy vs radiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data indicate that, in women with cervical cancer lesions of (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - October 31, 2009 Category: OBGYN Authors: Nisha Bansal, Thomas J. Herzog, Richard E. Shaw, William M. Burke, Israel Deutsch, Jason D. Wright Tags: Oncology Source Type: journals

EBRT has better biochemical outcomes than RP in high-risk prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients treated with external beam radiotherapy for high-risk prostate cancer have significantly better outcomes than those treated with radical prostatectomy, according to Italian research. (Source: MedWire News - Prostate Cancer)
Source: MedWire News - Prostate Cancer - October 31, 2009 Category: Cancer & Oncology Source Type: news

Commentary on Salvage robotic-assisted radical prostatectomy: Initial results and early report of outcomes: Boris RS, Bhandari A, Krane LS, Eun D, Kaul S, Peabody JO, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate the initial results of salvage robotic-assisted radical prostatectomy (SRARP) after recurrence following primary radiotherapy (RT) for localized prostate cancer.Between December 2002 and January 2008, 11 patients had SRARP with pelvic lymph node dissection by 1 surgeon from 1 institution. Six patients had brachytherapy, 3 had external beam RT (EBRT), 1 intensity-modulated RT, and 1 received brachytherapy with an EBRT boost. All patients had prostate cancer on biopsy after RT, with negative computed tomography and bone scan. The mean (range) follow-up was 20.5 (1–77) months.The mean interval from RT to SRARP w...
Source: Urologic Oncology: Seminars and Original Investigations - October 30, 2009 Category: Urology & Nephrology Authors: Joseph Smith Tags: Urologic Oncology Survey Source Type: journals

EBRT has better biochemical outcomes than RP in high-risk prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients treated with external beam radiotherapy for high-risk prostate cancer have significantly better outcomes than those treated with radical prostatectomy, according to Italian research. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - October 30, 2009 Category: Cancer & Oncology Source Type: news

Differentiation of Recurrent Glioblastoma Multiforme from Radiation Necrosis after External Beam Radiation Therapy with Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging [Neuroradiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we showed that quantitative measurement of hemodynamic values derived from T2*-weighted dynamic susceptibility-weighted contrast material–enhanced MR imaging results can be used to distinguish recurrent glioblastoma multiforme from external beam radiation therapy–induced necrosis. (Source: Radiology)
Source: Radiology - October 28, 2009 Category: Radiology Authors: Barajas, R. F., Chang, J. S., Segal, M. R., Parsa, A. T., McDermott, M. W., Berger, M. S., Cha, S. Tags: Neuroradiology Source Type: journals

Randomized Trial Of External Beam Radiotherapy Versus Cryoablation In Patients With Localized Prostate Cancer: Quality Of Life OutcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
UroToday.com - In the online edition of Cancer, Dr. John Robinson and associates present QoL outcomes from a single institution randomized trial comparing external beam radiotherapy (EBRT) with cryotherapy for localized prostate cancer (CaP). They previously reported a non-inferiority oncologic outcome for cryotherapy in this study. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 26, 2009 Category: Consumer Health News Tags: Prostate / Prostate Cancer Source Type: news

Use of force plate analysis to evaluate the efficacy of external beam radiation to alleviate osteosarcoma painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A standard of therapy for osteosarcoma includes amputation with or without adjuvant chemotherapy. There is a subset of dogs with osteosarcoma that are unsuitable for amputation. We evaluated kinetic variables in dogs with appendicular osteosarcoma treated with a single 8 Gy dose of radiation. Eighteen pet dogs with appendicular osteosarcoma received one 8 Gy fraction of palliative radiation on day 0. Force plate measurements and clinical assessments were made on days 0, 7, 14, and 21. Peak vertical forces (Fz) were recorded for each limb and a symmetric index (SI) was calculated. There were no significant changes in kineti...
Source: Veterinary Radiology & Ultrasound - October 26, 2009 Category: Veterinary Research Authors: JEFF I. WEINSTEIN, SARAH PAYNE, JEAN M. POULSON, CHIEKO AZUMA Tags: RADIATION ONCOLOGY Source Type: journals

IPF 2009 - Approach to local failure after radiation therapy - Session HighlightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IZMIR, TURKEY (UroToday.com) - The PSA level after external beam radiation therapy should be low (< 1ng/ml), but there is... (Source: UroToday)
Source: UroToday - October 25, 2009 Category: Urology & Nephrology Tags: Browse Categories - Prostate Cancer Source Type: info

[Definitive treatment of anal canal carcinoma with radiotherapy: Adverse impact of a pre-radiation resection. A retrospective study of 57 patients treated with curative intent.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Radiotherapy and chemoradiation with cisplatine-based chemotherapy cure a vast majority of patients with epidermoid carcinoma of the anal canal. Therapeutic factors that may interfere with the definition of the target volume and the patients' repositioning may decrease the efficacy of radiotherapy. Pre-radiotherapy surgical resection should be avoided. PMID: 19854092 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - October 22, 2009 Category: Cancer & Oncology Authors: Coquard R, Cenni JC, Artru P, Chalabreysse P, Queneau PE, Taieb S, Alessio A, Lledo G Tags: Cancer Radiother Source Type: journals

Single dose radiotherapy during surgery for breast cancer patients where external beam radiation was not feasible - results after 3 years of follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Intra-operative radiotherapy (IORT) with Intrabeam® (Carl Zeiss, Germany) has been used since 2000 in the international randomised TARGIT Trial to determine if there is equivalence between the novel IORT technique and conventional external beam radiotherapy (EBRT) in women with early breast cancer. Some patients were unsuitable for inclusion in our trial for a number of reasons and were given IORT as a single treatment off-trial. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Mohammed Keshtgar, J. Vaidya, C. Stacey, J. Tobias, N. Williams, M. Baum Tags: Abstracts Source Type: journals

Treatment outcome with low-dose-rate interstitial brachytherapy in early-stage oral tongue cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion</b> : BT, as an integral part of radical radiation therapy in early-stage tongue cancers, appears to be an effective alternative treatment modality with preservation of the organ and function without jeopardizing the outcome. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - October 16, 2009 Category: Cancer & Oncology Authors: Bhalavat Rajendra I, Mahantshetty Umesh M, Tole Sanjay, Jamema Swamidas V Source Type: journals

Gains From Real-Time Tracking of Prostate Motion During External Beam Radiation TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Real-time motion tracking and threshold-based intrafractional intervention may play a significant roll in treatment margin reduction for a small fraction of patients but not for the general patient population. Four-dimensional treatments with prostate rotation correction can reduce the treatment margin more significantly. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 15, 2009 Category: Radiology Authors: Jin Sheng Li, Lihui Jin, Alan Pollack, Eric M. Horwitz, Mark K. Buyyounouski, Robert A. Price, Chang-Ming Ma Tags: Physics Contributions Source Type: journals

Radiotherapy and radiosurgery for benign skull base meningiomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Meningiomas located in the region of the base of skull are difficult to access. Complex combined surgical approaches are more likely to achieve complete tumor removal, but frequently at a cost of treatment related high morbidity. Local control following subtotal excision of benign meningiomas can be improved with conventional fractionated external beam radiation therapy with a reported 5-year progression-free survival up to 95%. New radiation techniques, including stereotactic radiosurgery (SRS), fractionated stereotactic radiotherapy (FSRT), and intensity-modulated radiotherapy (IMRT) have been developed as a more accurat...
Source: Radiation Oncology - October 13, 2009 Category: Cancer & Oncology Authors: Giuseppe MinnitiMaurizio AmichettiRiccardo Maurizi Enrici Source Type: journals

Remarks on reporting and recording consistent with the ICRU Reference DoseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The authors advocate reporting the PTV median dose or preferably the mean dose of the central dose plateau PTVx as a potential replacement or successor of the ICRU Reference Dose - both usable for CRT and IMRT. (Source: Radiation Oncology)
Source: Radiation Oncology - October 13, 2009 Category: Cancer & Oncology Authors: Klaus BratengeierMarkus OechsnerMark GaineyMichael Flentje Source Type: journals

Interventions for dysphagia in oesophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Published October 2009 Summary: Most patients with oesophageal cancer undergo palliative treatment due to diagnosis at an advanced stage. The optimal palliative technique for dysphagia is not established despite significant progress in endoscopic techniques. The main objective of palliative treatment in patients with inoperable oesophageal or gastro-oesophageal junctional cancers is to achieve adequate improvement in dysphagia and quality of life, with a reduced need for additional interventions. Insertion of self-expanding metal stents is safe and provides swift relief of dysphagia. Other techniques, such as external beam...
Source: Gastroenterology and Liver Diseases Specialist Library - Oesophagus - October 13, 2009 Category: Gastroenterology Source Type: organizations

ASCO Breast: Two Types of Radiation Therapy Yield Same AppearanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAN FRANCISCO (MedPage Today) -- Cosmetic outcomes appear the same whether breast cancer patients get radiation therapy directly to the tumor bed during surgery or afterward with the conventional external beam approach, according to a randomized trial. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - October 13, 2009 Category: Hematology Source Type: news

Further Perspectives on Treating Localized Prostate CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Standard treatment options for prostate cancer patients include surveillance, surgery, external-beam radiotherapy, brachytherapy, the combination of external-beam and brachytherapy, and the combination of radiotheraputic modalities with hormonal therapy, for appropriately chosen patients. (Source: Cancer Network)
Source: Cancer Network - October 13, 2009 Category: Cancer & Oncology Source Type: info

The Allegheny General Modification of the Harvard Breast Cosmesis Scale for the Retreated BreastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Repeat lumpectomy and retreatment radiotherapy following ipsilateral breast tumor recurrence (IBTR) by either external-beam irradiation or brachytherapy in lieu of salvage mastectomy is an area of significant recent clinical interest. Multiple authors have reported their results, with encouraging numbers of patients avoiding mastectomy. (Source: Cancer Network)
Source: Cancer Network - October 13, 2009 Category: Cancer & Oncology Source Type: info

Early PSA decrease is an independent predictive factor of clinical failure and specific survival in patients with localized prostate cancer treated by radiotherapy with or without androgen deprivation therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A PSA decline 6 weeks after the start of EBRT when used as monotherapy and 3 months after the start of ADT in patients treated with combined ADT and EBRT is predictive of progression and specific survival. PMID: 19825885 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 12, 2009 Category: Cancer & Oncology Authors: de Crevoisier R, Slimane K, Messai T, Wibault P, Eschwege F, Bossi A, Koscielny S, Bridier A, Massard C, Fizazi K Tags: Ann Oncol Source Type: journals

Cryoablation versus EBRT: sexual function problems only QoL disadvantageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Men with prostate cancer who are concerned about retaining sexual function after treatment should be advised to choose external beam radiation therapy over cryoablation, according to Canadian research. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - October 12, 2009 Category: Cancer & Oncology Source Type: news

Cryoablation versus EBRT: sexual function problems only QoL disadvantageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Men with prostate cancer who are concerned about retaining sexual function after treatment should be advised to choose external beam radiation therapy over cryoablation, according to Canadian research. (Source: MedWire News - Prostate Cancer)
Source: MedWire News - Prostate Cancer - October 12, 2009 Category: Cancer & Oncology Source Type: news

Secondary gliosarcoma after diagnosis of glioblastoma: clinical experience with 30 consecutive patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The data underscore the difficulty associated with management of this disease. The strikingly poor survival of patients with SGS who had previously received combined radiation and temozolomide chemotherapy for GBM may reflect a unique molecular profile of GBM that eventually recurs as SGS. Further work will be required, controlling for multiple prognostic factors with larger numbers of patients. PMID: 19817543 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - October 8, 2009 Category: Neurosurgery Authors: Han SJ, Yang I, Otero JJ, Ahn BJ, Tihan T, McDermott MW, Berger MS, Chang SM, Parsa AT Tags: J Neurosurg Source Type: journals

Immediate Reconstruction with an Expander/Implant Following Ablatio Mammae because of Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Adjuvant radiotherapy with the use of a subtotally filled expander prior to definitive allogenous breast reconstruction is feasible with acceptable morbidity. An interdisciplinary consultation concerning the cosmetic outcome and potential side effects is absolutely necessary. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00066-009-2013-9Authors Marc D. Piroth, University Hospital, RWTH Aachen Department of Radiotherapy Aachen GermanyDaniela M. Piroth, University Hospital, RWTH Aachen Department of Gynecology and Obestrics Aachen GermanyMichael Pinkawa, University Hosp...
Source: Strahlentherapie und Onkologie - October 6, 2009 Category: Cancer & Oncology Tags: Strahlentherapie und Onkologie Source Type: journals

Estimated Dose to the Rectum and Colon in Prostate Cancer Patients Treated with Exclusive Radiation Therapy Presenting a Secondary Colorectal MalignancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest that the administered dose after EBRT for prostate cancer to the colon, excluding the rectum, may be below the Gy unit in sCRC patients. (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: D.C. Weber, H. Wang, C. Bouchardy, A. Rosset, E. Rapiti, F. Schmidlin, M. Rouzaud, R. Miralbell Tags: Original Article Source Type: journals

Background, Rationale and Goals for the 2010 International Consensus Conference Bone Metastasis Treatment WorkshopEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
External beam radiotherapy continues to be a mainstay for the successful treatment of patients with symptoms caused by cancer. The delivery of palliative radiotherapy is effective, time-efficient, relatively inexpensive and associated with a low risk of side-effects . However, the management of patients with painful bone metastases is complex and requires the integration of several medical disciplines. That complexity, coupled with the lack of palliative care guidelines, helped lead to the formation of the First International Consensus Workshop on radiation in the treatment of metastatic and locally advanced cancer in 1990...
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: S.T. Lutz, A. Fairchild, E. Chow, P. Hoskin Tags: Editorials Source Type: journals

Combining Systemic Bisphosphonates with Palliative External Beam Radiotherapy or Bone-Targeted Radionuclide Therapy: Interactions and EffectivenessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bisphosphonates, external beam radiotherapy and bone-seeking radiopharmaceuticals (BSRs) have an established role for the management of metastatic bone disease. Radiotherapy achieves significant pain relief and a decrease in local skeletal complication rates . The exact mechanism by which pain relief is achieved is unknown. It has been suggested that a high level of tumour and inflammatory cell kill and the subsequent decrease in osteoclastic activity play a role . BSRs bring about a similar effect in areas of increased uptake by local radiation emission. These mechanisms may be an important link for the possible synergist...
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: V. Vassiliou, Ø. Bruland, N. Janjan, S. Lutz, D. Kardamakis, P. Hoskin Tags: Editorials Source Type: journals

Challenging non-traumatic posterior urethral strictures treated with urethroplasty: a preliminary reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Posterior non-traumatic strictures refractory to minimal invasive procedures (dilation/endoscopic urethrotomy) can be treated by urethroplasty using an anastomotic repair with a bladder neck incision if necessary. (Source: International Braz J Urol)
Source: International Braz J Urol - October 2, 2009 Category: Urology & Nephrology Source Type: journals

Editorial CommentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In my view, there is sufficient evidence that external beam radiation therapy (EBRT) in the doses used to treat adenocarcinoma of the prostate leads to a small but definite risk of in-field, and likely other, malignancies. There are at least 2 implications after the clinician acknowledges this. The first relates to the discussion with men with newly diagnosed clinically localized prostate cancer (PC). A urologist and possibly a radiation oncologist will review the treatment alternatives and in doing so will include the important discussion of side effects—both immediate and late. Typically, the treatment approaches will ...
Source: Urology - September 30, 2009 Category: Urology & Nephrology Authors: Mark S. Soloway Tags: Oncology Source Type: journals

Treatment of early prostate cancer: radiotherapy, including brachytherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors discuss the radical treatment of early localised prostate cancer by external beam radiotherapy and interstitial therapy, also called prostate brachytherapy. They outline the different techniques available and emphasise the importance of discussing the relative advantages and disadvantages of each with the patient. Copyright © 2009 Wiley Interface Ltd (Source: Trends in Urology, Gynaecology and Sexual Health)
Source: Trends in Urology, Gynaecology and Sexual Health - September 28, 2009 Category: OBGYN Authors: Alison Tree, Vincent Khoo Tags: Prostate Cancer Source Type: journals

Differentiation of Recurrent Glioblastoma Multiforme from Radiation Necrosis after External Beam Radiation Therapy with Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging [Neuroradiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings suggest that DSC perfusion MR imaging may be used to differentiate recurrent GBM from EBRT-induced radiation necrosis. Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.2532090007/-/DC1 © RSNA, 2009 (Source: Continuous Publishing articles)
Source: Continuous Publishing articles - September 28, 2009 Category: Radiology Authors: Barajas, R. F., Chang, J. S., Segal, M. R., Parsa, A. T., McDermott, M. W., Berger, M. S., Cha, S. Tags: Neuroradiology Source Type: journals

Differentiation of Recurrent Glioblastoma Multiforme from Radiation Necrosis after External Beam Radiation Therapy with Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings suggest that DSC perfusion MR imaging may be used to differentiate recurrent GBM from EBRT-induced radiation necrosis. Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.2532090007/-/DC1 (c) RSNA, 2009. PMID: 19789240 [PubMed - as supplied by publisher] (Source: Radiology)
Source: Radiology - September 28, 2009 Category: Radiology Authors: Barajas RF, Chang JS, Segal MR, Parsa AT, McDermott MW, Berger MS, Cha S Tags: Radiology Source Type: journals

A survey of techniques to reduce and manage external beam radiation-induced xerostomia in British oncology and radiotherapy departmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Xerostomia is the most common side effect of external beam radiotherapy to the head and neck [Anand A, Jain J, Negi P, Chaudhoory A, Sinha S, Choudhury P, et-al. Can dose reduction to one parotid gland prevent xerostomia? – A feasibility study for locally advanced head and neck cancer patients treated with intensity-modulated radiotherapy. Clinical Oncology 2006;18(6):497–504.]. A survey was carried out in British oncology departments to determine what treatment regimes, to minimise xerostomia, are used for patients with head-and-neck cancers treated with external beam radiotherapy.A semi-structured questionn...
Source: Radiography - September 28, 2009 Category: Radiology Authors: Andrew Macknelly, Jane Day Tags: Original Articles Source Type: journals

Planned neck dissection following primary chemoradiation for advanced-stage head and neck cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Planned neck dissection in the setting of advanced neck disease following chemoradiation should remain an important consideration when counseling patients presenting with advanced cervical metastasis from squamous cell head and neck cancer. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - September 28, 2009 Category: ENT & OMF Authors: Peter R. Sabatini, Yadranko Ducic Tags: Head and Neck Surgery Source Type: journals

[Review on the effectiveness of prostate cancer brachytherapy]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ultrasound-guided transperineal prostate brachytherapy is now widely used modality in the treatment of prostate cancer. The overall prostate-specific antigen (PSA) progression-free survival at 10 years is 80-90% for low-risk patients. The results of long-term follow-up have showed better biochemical disease-free survival after I-125 and Pd-103 brachytherapy than after conventional external-beam radiotherapy and similar survival after radical prostatectomy. The most commonly reported dosimetric quantifiers include D90 (the dose that covers 90% of the prostate volume outlined on postimplant computed tomography images) an...
Source: Medicina (Kaunas) - September 25, 2009 Category: Universities & Medical Training Authors: Inciūra A, Jarusevicus L, Vaiciūnas K, Juozaityte E Tags: Medicina (Kaunas) Source Type: journals

Paragangliomas of head and neck: a treatment option with CyberKnife radiosurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, CyberKnife radiosurgery appears to be both safe and effective in the treatment of skull base paragangliomas. Determining whether long-term complications will arise will require further investigation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-009-0138-3Authors Livia C. Bianchi, CyberKnife Center CDI Milan ItalyMarcello Marchetti, Fondazione IRCCS Istituto Neurologico Carlo Besta Department of Neurosurgery, Division of Radiotherapy Milan ItalyLorenzo Brait, CyberKnife Center CDI Milan ItalyAchille Bergantin, CyberKnife Center CDI Milan ItalyIda Milanesi, Fondazione IRCCS Is...
Source: Neurological Sciences - September 23, 2009 Category: Neurology Tags: Neurological Sciences Source Type: journals