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VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hairy cell leukemia variant (HCLv) presents with high disease burden, lack of typical antigens like CD25, and poor response to standard treatments like cladribine. Occasionally, patients with classic HCL respond poorly. Clinical and molecular features of HCL and HCLv has not been compared. Rearrangements expressing immunoglobulin VH chain were sequenced, including 22 from 20 patients with HCLv and 63 from 62 patients with classic HCL. Most patients were seeking relapsed/refractory trials, representing a poor-prognosis population. VH4-34, a gene commonly used in autoimmune disorders, was observed in 8 (40%) HCLv and 6 (10%)...
Source: Blood - November 19, 2009 Category: Hematology Authors: Arons, E., Suntum, T., Stetler-Stevenson, M., Kreitman, R. J. Tags: Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: journals

Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single-agent cladribine and with more aggressive behaviorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hairy cell leukemia (HCL) is generally responsive to single-agent cladribine, and only a minority of patients are refractory and with poor prognosis. HCLs generally express mutated (M) and, in a minority, unmutated (UM) IGHV. In a multicenter clinical trial in newly diagnosed HCL, we prospectively investigated clinical and molecular parameters predicting response and event-free survival after single-agent cladribine. Of 58 HCLs, 6 expressed UM-IGHV (UM-HCL) and 52 M-IGHV (M-HCL). Beneficial responses were obtained in 53 of 58 patients (91%), whereas treatment failures were observed in 5 of 58 patients (9%). Failures were a...
Source: Blood - November 19, 2009 Category: Hematology Authors: Forconi, F., Sozzi, E., Cencini, E., Zaja, F., Intermesoli, T., Stelitano, C., Rigacci, L., Gherlinzoni, F., Cantaffa, R., Baraldi, A., Gallamini, A., Zaccaria, A., Pulsoni, A., Gobbi, M., Tassi, M., Raspadori, D., Leoncini, L., Rinaldi, A., Sabattini, E. Tags: Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: journals

IG genes and hairy cell leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Blood)
Source: Blood - November 19, 2009 Category: Hematology Authors: Caligaris-Cappio, F. Tags: INSIDE BLOOD Source Type: journals

Persistent non-neoplastic gammadelta-T cells in cerebrospinal fluid of a patient with hepatosplenic (gammadelta) T cell lymphoma: a case report with 6 years of flow cytometry follow-up.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of a 31-year old man diagnosed with a gammadelta HSTCL in 2003, successfully treated with chemotherapy and allogeneic stem cell transplantation, and followed from 2003 to present. Four-color flow cytometry (FC) was performed on a BD FACSCalibur and data analyzed with CellQuest Pro and FCS Express software. For cerebrospinal fluid (CSF), all cells were acquired due to limited material. Cytological correlation was available on all specimens. Molecular studies for T-cell gene rearrangement were non-contributory. By FC, the diagnostic HSTCL immunophenotype was CD3 (+), CD7 (+), CD2 (+), CD5 (-), CD4 (-), CD8...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Jiang L, Abati AD, Wilson W, Stetler-Stevenson M, Yuan C Tags: Int J Clin Exp Pathol Source Type: journals

Biology and Clinical Significance of Tartrate-Resistant Acid Phosphatases: New Perspectives on an Old EnzymeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Type 5 tartrate-resistant acid phosphatase (TRAP) has been a clinically relevant biomarker for about 50 years. It has always been a reliable and specific cytochemical marker for hairy cell leukemia and for differentiated cells of monocytic lineage. Only recently has the test for serum TRAP activity been accepted as sensitive and specific enough for clinical use as a marker of osteoclasts and bone resorption. This has come about through steady advances in knowledge about TRAP enzymology, structure, function, and molecular regulation and a consequent appreciation that TRAP isoforms 5a and 5b have...
Source: Calcified Tissue International - November 14, 2009 Category: Orthopaedics Tags: Calcified Tissue International Source Type: journals

Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia. PMID: 19880779 [PubMed - in process] (Source: Haematologica)
Source: Haematologica - November 1, 2009 Category: Hematology Authors: Dictor M, Ek S, Sundberg M, Warenholt J, György C, Sernbo S, Gustavsson E, Abu-Alsoud W, Wadström T, Borrebaeck C Tags: Haematologica Source Type: journals

Insight into the molecular pathogenesis of hairy cell leukaemia, hairy cell leukaemia variant and splenic marginal zone lymphoma, provided by the analysis of their IGH rearrangements and somatic hypermutation patternsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Haematology)
Source: British Journal of Haematology - October 22, 2009 Category: Hematology Authors: Sarah L. Hockley, Stavroula Giannouli, Alison Morilla, Andrew Wotherspoon, Gareth J. Morgan, Estella Matutes, David Gonzalez Source Type: journals

Hairy cell leukemia responsive to anti-thymocyte globulin used as immunosuppressive therapy for aplastic anemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hairy cell leukemia (HCL) is occasionally misdiagnosed as aplastic anemia when only a few leukemic cells are present in the circulation. Here, we describe a patient with HCL who initially presented with pancytopenia and received a diagnosis of aplastic anemia. The patient was treated with immunosuppressive therapy including cyclosporine A and anti-thymocyte globulin (ATG). No blood cell transfusion was required for approximately 3 years after ATG therapy. She was referred to our hospital because of an abdominal mass and requiring periodic blood transfusions. A bone marrow biopsy at this time revealed proliferation of l...
Source: International Journal of Hematology - October 13, 2009 Category: Hematology Authors: Fujiwara S, Miyake H, Nosaka K, Yoshida M, Ishihara S, Horikawa K, Yonemura Y, Iyama K, Mitsuya H, Asou N Tags: Int J Hematol Source Type: journals

Late extramedullary relapse after allogeneic transplantation in a case of variant hairy cell leukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
roshchuk & G Dölken (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - October 11, 2009 Category: Hematology Authors: C BusemannF SchülerW KrügerT KieferM WuppermannM AndroshchukG Dölken Source Type: journals

Interferon as an alternative to purine analogues in the treatment of hairy cell leukaemia – response to Benz et alEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Haematology)
Source: British Journal of Haematology - October 6, 2009 Category: Hematology Authors: Daniel Catovsky, Monica Else, Claire Dearden, Estella Matutes Source Type: journals

Interferon as an alternative to purine analogues in the treatment of hairy cell leukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Haematology)
Source: British Journal of Haematology - October 6, 2009 Category: Hematology Authors: Rudolf Benz, Georg Stussi, Joerg Fehr Source Type: journals

Antibody-based therapy of leukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Review ArticlesJohn C. Morris, Thomas A. Waldmann, Expert Reviews in Molecular Medicine, Volume 11 , pp e29AbstractOver the past decade, monoclonal antibodies have dramatically impacted the treatment of haematological malignancies, as evidenced by the effect of rituximab on the response rate and survival of patients with follicular and diffuse large B cell non-Hodgkin's lymphoma. Currently, only two monoclonal antibodies are approved for treatment of relapsed acute myeloid leukaemia in older patients and B cell chronic lymphocytic leukaemia, respectively. Although not approved for such treatment, alemtuzumab is also activ...
Source: Expert Reviews in Molecular Medicine - September 30, 2009 Category: Molecular Biology Source Type: journals

VH4-34+ Hairy Cell Leukemia, a New Variant With Poor Prognosis Despite Standard TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
VH4-34 status relates to poorer response to cladribine and shorter survival among patients with HCLv. Hairy cell leukemia variant (HCLv) presents with high disease burden, lack of typical antigens like... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - September 22, 2009 Category: Cancer & Oncology Source Type: journals

Hairy cell leukemia presenting as multiple discrete hepatic lesions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The involvement of hairy cell leukemia in the liver is in the form of portal and sinusoidal cellular infiltration. Here we describe the first case of hepatic hairy cell leukemia presenting as multiple discrete lesions, which was treated successfully. We suggest that in the investigation of discrete hepatic lesions in cases of cancer of unknown primary, hairy cell leukemia should be considered. The excellent response of hairy cell leukemia to therapy highlights the need for such a consideration. PMID: 19764101 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 20, 2009 Category: Gastroenterology Authors: Sahar N, Schiby G, Davidson T, Kneller A, Apter S, Farfel Z Tags: World J Gastroenterol Source Type: journals

Management of hematological malignancies during pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The management of hematological malignancies during pregnancy is a challenging endeavor, which not only requires technical skills and knowledge by the clinicians but also requires sound clinical judgment and compassion, keeping in mind the patient and family preferences and, ultimately, the wellbeing of the neonate. The incidence of hematological malignancies during pregnancy is rare, ranging from 1 in 1,000 to 1 in 10,000 deliveries, impeding the design and execution of large prospective studies. The purpose of this review is to evaluate the limited existing data and make useful suggestions in the management of acute and ...
Source: American Journal of Hematology - September 15, 2009 Category: Hematology Authors: Tina Rizack, Anthony Mega, Robert Legare, Jorge Castillo Source Type: journals

Hairy Cell Leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Progress in the treatment of patients with hairy cell leukemia (HCL) has led to a significant change in the natural history of the disease. With current regimens, the majority of patients achieve a complete remission, and their survival curves are similar to those for appropriate age-matched individuals without the disease. At the same time, new technologies are allowing better understanding of the molecular mechanisms responsible for the pathogenesis of this and other indolent lymphoid neoplasms. Several studies using modern techniques with different sensitivities have demonstrated the persistence of minimal residual ...
Source: Clinical Lymphoma and Myeloma - August 31, 2009 Category: Cancer & Oncology Authors: Ravandi F Tags: Clin Lymphoma Myeloma Source Type: journals

Characterization of c-Maf transcription factor in normal and neoplastic hematolymphoid tissue and its relevance in plasma cell neoplasia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
c-Maf, a leucine zipper-containing transcription factor, is involved in the t(14;16)(q32;q23) translocation found in 5% of myelomas. A causal role for c-Maf in myeloma pathogenesis has been proposed, but data on c-Maf protein expression are lacking. We therefore studied the expression of c-Maf protein by immunohistochemical analysis in myelomas and in a wide variety of hematopoietic tissue. c-Maf protein was detected in a small minority (4.3%) of myelomas, including a t(14;16)(q32;q22-23)/IgH-Maf+ case, suggesting that c-Maf protein is not expressed in the absence of c-Maf rearrangement. In contrast, c-Maf was strongly...
Source: American Journal of Clinical Pathology - August 20, 2009 Category: Pathology Authors: Natkunam Y, Tedoldi S, Paterson JC, Zhao S, Rodriguez-Justo M, Beck AH, Siebert R, Mason DY, Marafioti T Tags: Am J Clin Pathol Source Type: journals

Rare lymphoid malignancies of the breast: a report of two cases illustrating potential diagnostic pitfallsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe two cases of lymphoid malignancies predominantly involving the breast, both presenting diagnostic dilemmas. The first case, ALK-negative anaplastic large-cell lymphoma involving a seroma associated with a breast implant, is an emerging clinicopathologic entity. Anaplastic large-cell lymphoma has been identified in association with breast implants and seroma formation relatively recently. The second case, hairy cell leukemia involving the breast and ipsilateral axillary sentinel lymph node, is, to our knowledge, the first reported case of hairy cell leukemia involving the breast at the time of diagnosis. Wh...
Source: Journal of Hematopathology - August 20, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immunogenicity of non-human proteins with useful therapeutic properties has prevented their development for use in the therapy of disease. However, this class of proteins could be very useful, if their immunogenicity could be markedly reduced so that many treatment cycles could be administered. One approach to reduce the immunogenicity of foreign proteins is to identify B-cell epitopes on the protein and eliminate them by mutagenesis. In this article, theoretical aspects and experimental evidence for the feasibility of B cell epitope removal is reviewed. A special focus is given to our results with deimmunization of re...
Source: Advanced Drug Delivery Reviews - August 9, 2009 Category: Drugs & Pharmacology Authors: Nagata S, Pastan I Tags: Adv Drug Deliv Rev Source Type: journals

Acquired Glanzmann's thrombasthenia associated with Hairy cell leukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - July 8, 2009 Category: Journals (General) Authors: M. Kannan, T. Chatterjee, F. Ahmad, R. Kumar, V. P. Choudhry, R. Saxena Source Type: journals

Novel drugs for chronic lymphoid leukemias: mechanism of action and therapeutic activity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic lymphoid leukemias include well defined mature B-cell and T-cell neoplasms with diverse natural history and specific morphological, immunophenotypic and molecular characteristics. The most common adult leukemia in the Western world is chronic lymphocytic leukemia (CLL). Rarer indolent lymphoid leukemias include prolymphocytic leukemia, hairy cell leukemia, large granular lymphocyte leukemia and T-cell leukemia/lymphoma. Recently, several new agents have been explored and have shown promise in CLL treatment. Novel therapies are being evaluated both in pre-clinical studies and in early clinical trials. These trea...
Source: Current Medicinal Chemistry - June 28, 2009 Category: Chemistry Authors: Robak T Tags: Curr Med Chem Source Type: journals

Risk factors for severe infection in patients with hairy cell leukemia: a long-term study of 73 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although the survival of patients with hairy cell leukemia (HCL) has been improved by the therapeutic introduction of interferon [alpha] and purine analogs, it is still worsened by complications such as severe infections. In this long-term study, we identified factors influencing patient outcomes in 73 patients with HCL. Median age at diagnosis was 53 yr and the gender ratio (M/F) was 2.3. At the time of HCL diagnosis, 60 patients (82%) were symptomatic and 22 of these had an infection. After a median follow-up of 13 yr, eight patients had died of secondary cancer (n = 2), HCL progression (n = 1) and age-related complicati...
Source: European Journal of Haematology - June 26, 2009 Category: Hematology Authors: Ghandi Damaj, Frédérique Kuhnowski, Jean-Pierre Marolleau, Francis Bauters, Xavier Leleu, Ibrahim Yakoub-Agha Source Type: journals

Bispecific immunotoxinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chemotherapy resistance is a frequent clinical dilemma in the therapy of many neoplasms. Since most cytotoxic drugs target DNA or cell proliferation, alternate methods of cancer therapy have been sought. A number of laboratories have synthesized and tested clinically immunotoxins. These protein agents consist of peptide cell-selective ligands coupled to catalytic toxins. The toxins damage cells by damaging plasma membranes or inactivating cytosolic protein synthesis. Clinical trials of immunotoxins have shown mixed results. Remissions have been observed with several immunotoxins for hematologic malignancies including denil...
Source: Leukemia Research - June 26, 2009 Category: Hematology Authors: Arthur E. Frankel, Jung Hee Woo Tags: Guest Editorials Source Type: journals

Commentary on the WHO classification of tumors of lymphoid tissues (2008): indolent B cell lymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The 4th edition of the World Health Organization classification of tumors of hematopoietic and lymphoid tissues introduces many new items to the classification scheme of the so-called indolent B cell lymphomas. New proposed entities, such as splenic B cell lymphoma/leukemia, unclassifiable, splenic diffuse red pulp small B cell lymphoma, hairy cell leukemia variant, pediatric follicular lymphoma, and pediatric marginal zone lymphoma have been coined, and some definitions of established diseases, such as chronic lymphocytic leukemia or Waldenström’s macroglobulinemia have been revised. One aspect o...
Source: Journal of Hematopathology - June 25, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

[Leukemia and Bone Marrow Transplantation] Phase II Trial of Recombinant Immunotoxin RFB4(dsFv)-PE38 (BL22) in Patients With Hairy Cell LeukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion BL22 activity in HCL is confirmed. Best responses to BL22 after cladribine failure are achieved before the patients develop massive splenomegaly or undergo splenectomy. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - June 17, 2009 Category: Cancer & Oncology Authors: Kreitman, Stetler-Stevenson, Margulies, Noel, FitzGerald, Wilson, Pastan Tags: Biological Therapy Leukemia and Bone Marrow Transplantation Source Type: journals

Specific skin lesions in hairy cell leukemia at presentation: case report and review of literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Skin involvement in hairy cell leukemia (HCL) at presentation is a relatively rare manifestation of the disease. A 60-year-old male patient in whom cutaneous lesions were the initial manifestation of hairy cell leukemia together with leukocytosis, monocytopenia, massive splenomegaly, and leukemic maculopapulous infiltration of the almost whole skin is described. The present case is the forth mentioned in the literature with specify of leukocytosis in peripheral blood, consisting mostly of hairy cells. The patient was treated with two courses of 2-chlorodeoxiadenosine (2-CdA, Cladribine) and splenect...
Source: Medical Oncology - June 17, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Survival in non-Hodgkin’s lymphoma by histology and family historyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results provide quantitative prognosis data for patients with NHL according to specific histologies. Patients with a familial NHL had a similar prognosis compared to patients with sporadic disease. The data suggest familial concordance in either good or poor survival among family members. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0618-0Authors Jianguang Ji, Lund University Center for Primary Health Care Research CRC, hus 28, plan 11, ing 72, UMAS 205 02 Malmö SwedenAsta Försti, Lund University Center for Primary Health Care Research CRC, hus 28, plan 1...
Source: Journal of Cancer Research and Clinical Oncology - June 17, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

[Original articles] Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results, based on case-by-case expert review of occupation-specific questionnaires, support the hypothesis that occupational pesticide exposures may be involved in HL, MM and HCL and do not rule out a role in NHL. The analyses identified specific pesticides that deserve further investigation and the findings were consistent with those of previous studies. (Source: Occupational and Environmental Medicine)
Source: Occupational and Environmental Medicine - April 17, 2009 Category: Occupational Health Authors: Orsi, L, Delabre, L, Monnereau, A, Delval, P, Berthou, C, Fenaux, P, Marit, G, Soubeyran, P, Huguet, F, Milpied, N, Leporrier, M, Hemon, D, Troussard, X, Clavel, J Tags: Original articles Source Type: journals

Sweet syndrome as the presenting symptom of hairy cell leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19336029 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - April 7, 2009 Category: Dermatology Authors: Ventura F, Rocha J, Pereira T, Marques H, Pardal F, Brito C Tags: Dermatol Online J Source Type: journals

[Treatments of Hodgkin and non-Hodgkin lymphomas.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The therapy of malignant lymphoproliferative diseases has changed many times in recent years. Treatment strategy of Hodgkin's disease is now based on risk adaptation, including not only the results of pretreatment diagnostic and prognostic factors but also the repeated PET/CT (restaging) made in the early treatment period. Possible reduction of irradiation therapy may contribute to lower the risk of secondary tumors, which are common late complications of radiochemotherapy. Autologous stem cell transplantation is the therapy of choice in chemosensitive relapsing patients. The complete remission rate today in Hodgkin's ...
Source: Orvosi Hetilap - April 5, 2009 Category: Journals (General) Authors: Sréter L Tags: Orv Hetil Source Type: journals

Establishment of a Hairy Cell Leukemia Variant Cell Line, HCLv-07.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19332987 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - April 1, 2009 Category: Hematology Authors: Sasaki M, Aritaka N, Tsukune Y, Kawahara S, Masuda A, Tsutsui M, Kanemitsu N, Sugimoto K Tags: Acta Haematol Source Type: journals

Achievement of complete remission of refractory hairy cell leukemia by rituximab progressing after allogeneic hematopoietic stem cell transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19330554 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - March 31, 2009 Category: Hematology Authors: Kiyasu J, Shiratsuchi M, Ohtsuka R, Sada E, Idutsu K, Nagasawa E, Takayanagi R, Abe Y Tags: Int J Hematol Source Type: journals

Long-term follow-up of 233 patients with hairy cell leukaemia, treated initially with pentostatin or cladribine, at a median of 16 years from diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hairy cell leukaemia (HCL) was first described 50 years ago. Median survival was then 4 years. The purine analogues, introduced in the 1980s, transformed this prognosis. We reviewed data retrospectively from 233 patients, treated with pentostatin (n = 188) or cladribine (n = 45), to investigate the current long-term outlook. Median follow-up was 16 years. There were no significant differences in outcome between the two agents. Overall, the complete response (CR) rate was 80% and median relapse-free survival was 16 years. After relapse (n = 79) or non-response (n = 5), 26 patients received pentostatin and 58 cladribine; 69%...
Source: British Journal of Haematology - March 29, 2009 Category: Hematology Authors: Monica Else, Claire E. Dearden, Estella Matutes, Juan Garcia-Talavera, Ama Z. S. Rohatiner, Steve A. N. Johnson, Nigel T. J. O'Connor, Andy Haynes, Nnenna Osuji, Francesco Forconi, Francesco Lauria, Daniel Catovsky Source Type: journals

Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CD103 is characteristically expressed in hairy cell leukemia (HCL), a B-lymphoproliferative disorder highly responsive to treatment with purine analogs. Other CD103+ diseases are rare and do not respond well to the same therapy, including HCL variant (HCLv) and splenic marginal zone B-cell lymphoma (SMZL) variants. We analyzed 215 cases of CD103+ B-lymphoproliferative disorders to further delineate their immunophenotypic features. Flow cytometric analysis revealed that 78.6% of all cases expressed CD25 and CD103, characteristic of classical HCL. Cases analyzed immunohistochemically were also invariably positive for ann...
Source: American Journal of Clinical Pathology - March 21, 2009 Category: Pathology Authors: Dong HY, Weisberger J, Liu Z, Tugulea S Tags: Am J Clin Pathol Source Type: journals

Hairy Cell Leukemia-Related Disorders Consistently Show Low CD27 Expression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In Japan, typical hairy cell leukemia (HCL) is rare, and HCL-Japanese variant (HCL-JV) is more common. Hairy B-cell lymphoproliferative disorder (HBLD) is another unusual disorder of polyclonal B-lymphocytosis of hairy cell appearance. In the present study, we analyzed the clinical features of 3 patients with HCL, 3 with HCL-JV, and 3 with HBLD. All HBLD patients had the DRB1*04 allele. As compared with other B-cell lymphoproliferative disorders, CD27 expression on B cells was significantly lower in all patients, ranging from 0.3% to 23.4%. Our results suggest that low CD27 expression may be a distinct feature of these...
Source: Pathology Oncology Research - March 20, 2009 Category: Pathology Authors: Hashimoto Y, Tsukamoto N, Nakahashi H, Yokohama A, Saitoh T, Handa H, Matsushima T, Murakami H, Nojima Y, Karasawa M Tags: Pathol Oncol Res Source Type: journals

Has Success Spoiled Hairy Cell Leukemia Research? Key Questions Go Unanswered, Despite Big GainsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JNCI)
Source: JNCI - March 17, 2009 Category: Cancer & Oncology Authors: Holzman, D. Tags: NEWS Source Type: journals

Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These familial aggregations are striking and provide novel clues to research designed to uncover early pathogenetic mechanisms in chronic lymphocytic leukemia including studies to identify germ line susceptibility genes. However, clinicians should counsel their chronic lymphocytic leukemia patients emphasizing that because the baseline population risks are low, the absolute risk for a first-degree relative to develop chronic lymphocytic leukemia or another indolent lymphoma is low. At this time, an increased medical surveillance of first-degree relatives of chronic lymphocytic leukemia patients has no role outs...
Source: Haematologica - March 13, 2009 Category: Hematology Authors: Goldin LR, Björkholm M, Kristinsson SY, Turesson I, Landgren O Tags: Haematologica Source Type: journals

CD200/OX2, a cell surface molecule with immuno-regulatory function, is consistently expressed on hairy cell leukaemia neoplastic cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Haematology)
Source: British Journal of Haematology - March 12, 2009 Category: Hematology Authors: Lorenzo Brunetti, Rosa Di Noto, Giovanna Abate, Marisa Gorrese, Angela Gravetti, Maddalena Raia, Giulia Scalia, Caterina Pascariello, Andrea Camera, Luigi Del Vecchio Source Type: journals

Visual disturbance as initial presentation of hairy cell leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS. The authors present a rare case in which bilateral visual complaints led to the diagnosis of HCL. Thus, though uncommon, HCL should be considered in the differential diagnosis of otherwise unexplained retinal hemorrhages. PMID: 19253258 [PubMed - in process] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - March 1, 2009 Category: Opthalmology Authors: Charalel R, Jain A, Rachakonda L, Gaynon M Tags: Eur J Ophthalmol Source Type: journals

CD26 expression in mature B-cell neoplasia: its possible role as a new prognostic marker in B-CLLEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CD26 (dipeptidyl peptidase IV, DPP IV) is widely expressed by T and natural killer (NK) cells, epithelial and endothelial cells of different tissues, and it is strongly upregulated in activated B-cells; moreover it plays a regulatory role in the neoplastic transformation and progression of various types of tumours. CD26 expression was evaluated by means of flow cytometry in various peripheral B-cell lymphoid tumours: 12 follicular and 12 mantle cell lymphomas, 20 multiple myelomas (MMs), 12 hairy cell leukaemias (HCLs), 112 chronic lymphocytic leukaemias (CLLs), 20 CD5negative B-cell chronic lymphoproliferative diseases (C...
Source: Hematological Oncology - February 26, 2009 Category: Hematology Authors: Lilla Cro, Fortunato Morabito, Nadia Zucal, Sonia Fabris, Marta Lionetti, Giovanna Cutrona, Francesca Rossi, Massimo Gentile, Andrea Ferrario, Manlio Ferrarini, Stefano Molica, Antonino Neri, Luca Baldini Source Type: journals

[Correspondence] Teenager With Hairy Cell Leukemia: 30-Year Follow-UpEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - December 29, 2008 Category: Cancer & Oncology Authors: Kilbridge, Kadin Tags: Correspondence Source Type: journals

Hairy-Cell Leukemia: 50 Years Of ResearchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 1958, Ohio State University cancer researcher Dr. Bertha Bouroncle first identified a deadly disease now known as hairy-cell leukemia, a once fatal disease that can now be effectively treated. Now, 50 years later researchers from across the globe are gathering for a symposium titled "50 years of Enormous Progress in Hairy Cell Leukemia: A Celebration of Clinical Research with Remaining Unanswered Questions. (Source: Lymphoma / Leukemia News From Medical News Today)
Source: Lymphoma / Leukemia News From Medical News Today - December 8, 2008 Category: Hematology Tags: Lymphoma / Leukemia Source Type: news

50 Years Of Hairy-Cell Leukemia Research To Be ObservedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 1958, Ohio State University cancer researcher Dr. Bertha Bouroncle first identified a deadly disease now known as hairy-cell leukemia, a once fatal disease that can now be effectively treated. (Source: Huliq Health News)
Source: Huliq Health News - December 6, 2008 Category: Consumer Health News Authors: harminka Tags: Health leukemia lymphocytic leukemia Source Type: news

50 years of hairy-cell leukemia research to be observedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Ohio State University Medical Center) In 1958, Ohio State University cancer researcher Dr. Bertha Bouroncle first identified a deadly disease now known as hairy-cell leukemia, a once fatal disease that can now be effectively treated. Now, 50 years later researchers from across the globe are gathering for a symposium titled "50 years of Enormous Progress in Hairy Cell Leukemia: A Celebration of Clinical Research with Remaining Unanswered Questions." (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 5, 2008 Category: Cancer & Oncology Source Type: news

Xanthones from the Seeds of Allanblackia monticola and Their Apoptotic and Antiproliferative ActivitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0028-1088375AbstractPhytochemical investigations of the seeds of have led to the isolation and characterization of one new xanthone derivative, named allanxanthone E (), together with seven known compounds, including five xanthones, 1,7-dihydroxy-3-methoxy-2-(3-methylbut-2-enyl)xanthone (), -mangostin () garciniafuran () allanxanthone C (), and 1,6-dihydroxy-2,4-diprenylxanthone (), and two pentacyclic triterpenes, friedelin and lupeol. The structures of these compounds were established on the basis of one- and two-dimensional NMR homo- and heteronuclear correlation evidence. Some of these compound...
Source: Planta Medica - December 4, 2008 Category: Drugs & Pharmacology Tags: Original Paper Source Type: journals

Non-traumatic splenic rupture: Report of seven cases and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: NSR is a rare entity that needs a high index of suspicion for diagnosis. Using ultrasonography or computer tomography, and peritoneal aspiration of fresh blood may assist in the diagnosis of NSR. Increased awareness of NSR can enhance early diagnosis and effective treatment. PMID: 19034976 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 21, 2008 Category: Gastroenterology Authors: Gedik E, Girgin S, Aldemir M, Keles C, Tuncer MC, Aktas A Tags: World J Gastroenterol Source Type: journals

Hairy Cell Leukemia with Unusual Loss of CD103 in a Subset of the Neoplastic Population: Immunophenotypic and Cell Cycle Analysis by Flow Cytometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual case of hairy cell leukemia (HCL) in a 55-year-old male who presented with fatigue, increased bruising, leukocytosis, anemia, thrombocytopenia and moderate splenomegaly without lymphadenopathy. Microscopically, a monomorphic population of small to medium-sized lymphoid cells with bean-shaped nuclei, ground glass chromatin and fine cytoplasmic projections was identified in the peripheral blood and bone marrow. Flow cytometric immunophenotyping demonstrated a monoclonal population of mature B cells with coexpression of CD25, CD11c and CD103. The clonal B-cells all exhibited homogenous expression of CD20 ...
Source: International Journal of Clinical and Experimental Pathology - November 2, 2008 Category: Pathology Authors: Yuan CM, Yang LJ Tags: Int J Clin Exp Pathol Source Type: journals

Mycobacterium kansasii in a patient with hairy cell leukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Haematology)
Source: British Journal of Haematology - October 16, 2008 Category: Hematology Authors: Laura Green, Adam Coumbe, Elizabeth Sawicka, Corinne De Lord Source Type: journals

Paraneoplastic scleroderma secondary to hairy cell leukaemia successfully treated with cladribineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Rheumatology)
Source: Rheumatology - October 16, 2008 Category: Rheumatology Authors: Juarez, M., Marshall, R., Denton, C., Evely, R. Tags: Systemic Sclerosis, Pharmacology CASE REPORTS Source Type: journals

Extranodal hairy cell leukemia presenting in the lumbar spine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors report on a 54-year-old man who presented with a lumbar vertebral body lesion and an adjacent epidural lesion that was found to be hairy cell leukemia (HCL). The patient presented with gradual onset of back pain and intermittent lower-extremity radicular symptoms. He did not have splenomegaly or peripheral blood count abnormalities. Admission MR imaging revealed an L-5 vertebral body lesion and a lumbar epidural lesion extending from L-3 to S-2. An [18F]fluorodeoxyglucose-PET study showed numerous sites of osseous involvement. The patient underwent minimally invasive surgical biopsy sampling of the epidural...
Source: Journal of Neurosurgery.Spine - October 1, 2008 Category: Neurosurgery Authors: Rosen DS, Smith S, Gurbuxani S, Yamini B Tags: J Neurosurg Spine Source Type: journals