HNSCCThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you your search results in order of date.

Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

743 records returned

Conditionally replicating adenovirus improves gene replication efficiency and anticancer effect of E1-deleted adenovirus carrying TRAIL in head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this combined strategy using CRAd and adenovirus carrying a therapeutic gene increased the gene transfer rate and enhanced antitumor effects. We expect that this combination strategy could be extended to a multitarget cancer gene therapy by combining multiple adenoviruses and CRAd. (Cancer Sci 2009) (Source: Cancer Science)
Source: Cancer Science - November 18, 2009 Category: Cancer & Oncology Authors: Seon-Hui Shim, Choon-Taek Lee, J. Hun Hah, Jae-Jung Lee, Seok-Woo Park, Dae Seog Heo, Myung-Whun Sung Source Type: journals

Moderate marijuana use may tamp risk of H&N cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cannabinoids, which are a byproduct of marijuana smoke, have been recognized to have potential antitumor properties, but evidence of a relationship between marijuana use and the induction of head and neck squamous cell carcinoma has been inconsistent. (Source: Cancer Network)
Source: Cancer Network - November 17, 2009 Category: Cancer & Oncology Source Type: info

Error in Text in: Comparison of Clinical and Pathological Staging in Head and Neck Squamous Cell Carcinoma: Results From Intergroup Study ECOG 4393/RTOG 9614 [Correction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - November 16, 2009 Category: ENT & OMF Tags: Oncology, Head & neck Cancer, Skin Cancer, Otolaryngology/ Head & neck Surgery, Neoplasms of Head & neck, Prognosis/ Outcomes Correction Source Type: journals

Immune Response During Therapy With Cisplatin or Radiation for Human Papillomavirus-Related Head and Neck Cancer [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The HPV-positive tumors are not more curable based on increased epithelial sensitivity to cisplatin or radiation therapy. Instead, radiation and cisplatin induce an immune response to this antigenic cancer. The implications of these results may lead to novel therapies that enhance tumor eradication for HPV-positive cancers. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - November 16, 2009 Category: ENT & OMF Authors: Spanos, W. C., Nowicki, P., Lee, D. W., Hoover, A., Hostager, B., Gupta, A., anderson, M. E., Lee, J. H. Tags: Oncology, Head & neck Cancer, Oncology, Other, Otolaryngology/ Head & neck Surgery, Neoplasms of Head & neck, Radiation Therapy, Drug Therapy, Drug Therapy, Other, Immunology, Immunology, Other Original Article Source Type: journals

Postoperative Reirradiation for Mucosal Head and Neck Squamous Cell Carcinomas [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Reirradiation represents the only chance for cure in patients with unresectable disease. After surgery, reirradiation is performed in patients at high risk of locoregional recurrence and may increase acute toxic effects. However, free-flap reconstruction may reduce toxic effects. Functional outcomes have declined since 2000 likely because of the addition of concurrent platinum-based chemotherapy. Future research may define the subpopulation of postoperative patients for whom survival benefits most outweigh reirradiation toxic effects. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - November 16, 2009 Category: ENT & OMF Authors: Iseli, T. A., Iseli, C. E., Rosenthal, E. L., Caudell, J. J., Spencer, S. A., Magnuson, J. S., Smith, A. N., Carroll, W. R. Tags: Oncology, Head & neck Cancer, Oncology, Other, Otolaryngology/ Head & neck Surgery, Neoplasms of Head & neck, Radiation Therapy Original Article Source Type: journals

Distinct population of highly malignant cells in a head and neck squamous cell carcinoma cell line established by xenograft modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The progression and metastasis of solid tumors, including head and neck squamous cell carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer stem cells. Here, we have established a highly malignant HNSCC cell line, SASVO3, from primary tumors using three sequential rounds of xenotransplantation. SASVO3 possesses enhanced tumorigenic ability both in vitro and in vivo. Moreover, SASVO3 exhibits properties of cancer stem cells, including that increased the abilities of sphere-forming, the number of side population cells, the potential of transplanted tumor growth and elevated expression of the...
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Chi-Yuan ChenShih-Hwa ChiouChih-Yang HuangChia-Ing JanShu-Chun LinMing-Long TsaiJeng-Fan Lo Source Type: journals

Clinicopathologic risk factors for distant metastases from head and neck squamous cell carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The number of levels with pathologic lymph node, the site of primary tumor and the level of tumor invasion are decisive risk factors in determining the development of DM in head and neck SCC patients. Patients with multilevel nodal involvement in neck, with laryngeal and hypopharyngeal carcinomas, and patients with primary tumor invasion into muscular, bone or cartilage have the highest risk of developing DM. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: X. Li, B. Di, Y. Shang, Y. Zhou, J. Cheng, Z. He Tags: Original Articles Source Type: journals

HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: HPV/p16-expression significantly improved outcome after radiotherapy in HNSCC. Hypoxic modification improved outcome in HPV/p16-negative tumours but was of no significant benefit in HPV/p16-positive tumours, suggesting that hypoxic radioresistance may not be clinically relevant in these tumours. PMID: 19910068 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 10, 2009 Category: Radiology Authors: Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J, Tags: Radiother Oncol Source Type: journals

Advances in Imaging in the Work-Up of Head and Neck Cancer PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current roles of CT and MRI in diagnosing HNSCC are discussed, along with the value of FDG-PET-CT in detecting occult LN metastases. Accurate staging at the time of the diagnosis of head and neck squamous... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - November 7, 2009 Category: Cancer & Oncology Source Type: journals

Hypoxia-inducible Factor-1-mediated Regulation of Semaphorin 4D Affects Tumor Growth and Vascularity [Molecular Basis Of Cell and Developmental Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumor progression and metastasis depend on the ability of cancer cells to initiate angiogenesis to ensure delivery of oxygen, nutrients, and growth factors to tumor cells and provide access to the systemic circulation. Hypoxia-inducible factor-1 (HIF-1) can activate expression of a broad range of genes that mediate many of the adaptive responses to decreased oxygen concentration, such as enhanced glucose uptake and formation of new blood vessels. Acting through Plexin-B1 on endothelial cells, Semaphorin 4D (Sema4D) has been shown to promote angiogenesis and enhance invasive growth and proliferation in some tumors. Here we ...
Source: Journal of Biological Chemistry - November 6, 2009 Category: Chemistry Authors: Sun, Q., Zhou, H., Binmadi, N. O., Basile, J. R. Tags: Molecular Basis Of cell and Developmental Biology Source Type: journals

Altered fractionation and adjuvant chemotherapy for head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this review was to discuss the role of altered fractionation and adjuvant chemotherapy for patients treated with definitive radiotherapy (RT) for head and neck squamous cell carcinoma (HNSCC).This review explores the pertinent literature and discusses the optimal management of previously untreated patients with stage III-stage IVA and/or -B HNSCCs.Depending on the schedule, altered fractionation improves locoregional control and survival. Both hyperfractionation and concomitant boost RT improve locoregional control and are associated with improved overall survival (OS). Adjuvant chemotherapy improves OS; the gre...
Source: Head and Neck - November 6, 2009 Category: ENT & OMF Authors: William M. Mendenhall, Charles E. Riggs, Mikhail Vaysberg, Robert J. Amdur, John W. Werning Source Type: journals

Research Results From University Of Texas Update Understanding Of Head And Neck CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We sought to improve outcomes for patients with high-risk head and neck squamous cell cancer (HNSCC) after surgical resection by testing the feasibility and safety of early postoperative chemotherapy followed by concurrent chemoradiotherapy. Eligible patients had resected, stages III to IV HNSCC with positive margins, extracapsular nodal extension, or multiple positive nodes, investigators in the United States report. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 6, 2009 Category: Cancer & Oncology Source Type: news

Localization of telomerase hTERT protein in frozen sections of basal cell carcinomas (BCC) and tumor margin tissues.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was supplemented with antibodies against Ki-67, nucleolin, common leucocyte antigen CD45 and mutated p53. The immunoreactive scores were determined and included the comparison with telomerase activity. The investigation of hTERT expression was performed in the tissues of 41 patients with BCC and control tissues of 14 patients without tumor. Eleven commercial antibodies were used for a nuclear staining of hTERT expression. With the anti-hTERT antibodies we looked for both satisfactory distribution and intensity of immunohistochemical labeling in the carcinomas and in the squamous epithelia of the tumor centers, o...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Fabricius EM, Kruse-Boitschenko U, Khoury R, Wildner GP, Raguse JD, Klein M, Hoffmeister B Tags: Int J Oncol Source Type: journals

High p16 Antibody Levels May Signal HPV Infection in Head and Neck CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In patients with head and neck squamous cell carcinoma, high p16 antibody expression might serve as a marker for infection with high-risk human papillomavirus (HPV). Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 3, 2009 Category: Consumer Health News Tags: Pathology & Lab Medicine Source Type: news

Accelerated fractionation radiotherapy and late intensification with 2 intra-arterial cisplatin infusions for locally advanced head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was established to determine the maximum tolerated dose of intra-arterial cisplatin (IAC) concurrent with accelerated fractionation radiotherapy for locally advanced head and neck squamous cell carcinoma (HNSCC).We conducted a phase I study. Treatment consisted of 70 Gy/35 fractions/5.8 weeks and 2 weekly IAC infusions during the last 2 weeks.Ten patients were recruited. Two patients had stage III, 1 had stage IVa, and 7 had stage IVb disease. Three patients received IAC at 100 mg/m2, 3 at 125 mg/m2, and 4 at 150 mg/m2. Nine patients received both planned infusions. Dose-limiting toxicity occurred at 150 mg/m2 a...
Source: Head and Neck - November 3, 2009 Category: ENT & OMF Authors: Kwok Hung Yu, Simon C. H. Yu, Edwin P. Hui, Michael K. M. Kam, Alexander C. Vlantis, Edmund Yuen, Anthony T. C. Chan Source Type: journals

Detection of metachronous esophageal squamous carcinoma in patients with head and neck cancer with use of transnasal esophagoscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of transnasal esophagoscopy was examined for detecting metachronous esophageal squamous carcinoma in patients with head and neck squamous cell carcinoma (HNSCC).In all, 398 transnasal esophagoscopies were performed in 293 previously treated patients with HNSCC between December 2007 and January 2009.Metachronous esophageal squamous carcinoma was detected in 15 (5.1%) patients. The prevalence rate was 15.9% (7/44) in patients with hypopharyngeal cancer, significantly higher than the 8.3% (2/24) with laryngeal, 7.1% (3/42) with oropharyngeal, and 1.6% (3/183) with oral cancer (p = .001). The stage distributions of eso...
Source: Head and Neck - November 3, 2009 Category: ENT & OMF Authors: Yan-Ye Su, Fu-Min Fang, Hui-Ching Chuang, Sheng-Dean Luo, Chih-Yen Chien Source Type: journals

Association of cystic neck metastases and human papillomavirus-positive oropharyngeal squamous cell carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human papillomavirus is an established cause of oropharyngeal squamous cell carcinoma. Similar to cervical cancer, these cancers are usually caused by high-risk human papillomavirus types 16 and 18 and are associated with high-risk sexual behaviors. Human papillomavirus-associated oropharyngeal squamous cell carcinoma typically affects the palatine and lingual tonsils and frequently results in cystic neck metastases. The histopathology of this subset of head and neck squamous cell carcinoma is unique and typically characterized by poorly differentiated, nonkeratinizing morphology with a basaloid appearance. These tumor...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: McHugh JB Tags: Arch Pathol Lab Med Source Type: journals

Nitric oxide synthase (NOS2/3) expression in head and neck squamous cell carcinomas in correlation with clinical patterns.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: HNSCCs are able to express both NOS protein isoforms in relevant amounts, and we presume that synthesized NO is able to support angiogenetic patterns and facilitate tumor progression and lymphatic spread. PMID: 19887869 [PubMed - in process] (Source: Onkologie)
Source: Onkologie - November 1, 2009 Category: Cancer & Oncology Authors: Mozet C, Marin DG, Bertolini J, Tannapfel A, Wichmann G, Dietz A Tags: Onkologie Source Type: journals

Curcumin inhibits cancers of the head and neckEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) The yellowish orange Indian spice turmeric, used to flavor curries, contains a remarkable phytochemical known as curcumin -- and this natural substance is the target of feverish research across a spectrum of medical disciplines. The reason? Curcumin has shown remarkable promise in helping the human body in a wide variety of ways. For example, as NaturalNews has previously reported, it may prevent Alzheimer's Disease (http://www.naturalnews.com/026861_curcumin_vitamin_D3_disease.html) and type 2 diabetes (http://www.naturalnews.com/024644.html) as well as fight breast and colorectal malignancies (http://www.na...
Source: NaturalNews.com - October 28, 2009 Category: Consumer Health Advice Source Type: news

Apoptin Enhances Radiation-Induced Cell Death in Poorly Responding Head and Neck Squamous Cell Carcinoma CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined whether chicken anaemia virus-derived apoptin protein would have a beneficial effect on irradiation of radiosensitive SCC61 and radioresistant SQD9 human head and neck squamous carcinoma cell lines. In both cell lines, concurrent exposure to irradiation and apoptin resulted in analysed mitochondrial cytochrome c release and in cleavage of caspase-3, whereas irradiation alone of SQD9 cells under identical conditions did not. Moreover, in comparison with the irradiation, only the synchronized treatment of apoptin and irradiation resulted in increased cell death in especially the radioresistant SQD9 cells, as meas...
Source: Basic and Clinical Pharmacology and Toxicology - October 28, 2009 Category: Drugs & Pharmacology Authors: Remilio A. L. Schoop, Elizabeth M. E. Verdegaal, Robert J. Baatenburg de Jong, Mathieu H. M. Noteborn Source Type: journals

Studies From Emory University Describe New Findings In Head And Neck CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
According to a study from the United States, Inhibition of cyclooxygenase-2 (COX-2) pathways may have significant implications for the prevention and treatment of head and neck squamous cell carcinoma (HNSCC). COX-2 is overexpressed in both premalignant lesions and invasive HNSCC. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - October 28, 2009 Category: Cancer & Oncology Source Type: news

2D-DIGE proteomic characterization of head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Downregulation of cornulin is a prominent feature of the molecular signature of HNSCC identified by comparative proteomics. Cornulin may represent a link between HNSCC and other pathologies arising in stratified squamous epithelium. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - October 27, 2009 Category: ENT & OMF Authors: Mark A. Merkley, Paul M. Weinberger, Lana L. Jackson, Robert H. Podolsky, Jeffrey R. Lee, William S. Dynan Tags: Head and neck Surgery Source Type: journals

Additional diagnostic value of 18F-FDG PET-CT in detecting retropharyngeal nodal metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: 18F-FDG PET-CT, when used in combination with CT/MRI, increases diagnostic efficacy in the detection of RPLN metastases and may therefore be useful in screening high-risk patients. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - October 27, 2009 Category: ENT & OMF Authors: Hyung Ro Chu, Jin Hwan Kim, Dae Young Yoon, Hee Sung Hwang, Young-Soo Rho Tags: Head and neck Surgery Source Type: journals

Human Papillomavirus in Head and Neck Cancer: Its Role in Pathogenesis and Clinical Implications.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with an annual incidence of approximately 400,000 worldwide. Although the principal risk factors for head and neck cancer remain tobacco and alcohol use, human papillomavirus (HPV) has recently been found to be etiologically associated with 20 to 25% of HNSCC, mostly in the oropharynx. HPV causes human cancers by expressing two viral oncoproteins, E6 and E7. These oncoproteins degrade and destabilize two major tumor suppressor proteins, p53 and pRb, through ubiquitination. Additional studies have shown that E6 and E7 can directly bind to mult...
Source: Clinical Cancer Research - October 27, 2009 Category: Cancer & Oncology Authors: Chung CH, Gillison ML Tags: Clin Cancer Res Source Type: journals

Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we found that Smad4 was frequently downregulated not only in human head and neck squamous cell carcinoma (HNSCC) malignant lesions, but also in grossly normal adjacent buccal mucosa. To gain insight into the importance of this observation, we generated mice in which Smad4 was deleted in head and neck epithelia (referred to herein as HN-Smad4–/– mice) and found that they developed spontaneous HNSCC. Interestingly, both normal head and neck tissue and HNSCC from HN-Smad4–/– mice exhibited increased genomic instability, which correlated with downregulated expression and function ...
Source: Journal of Clinical Investigation - October 23, 2009 Category: Biomedical Science Authors: Sophia Bornstein, Ruth White, Stephen Malkoski, Masako Oka, Gangwen Han, Timothy Cleaver, Douglas Reh, Peter andersen, Neil Gross, Susan Olson, Chuxia Deng, Shi-Long Lu, Xiao-Jing Wang Source Type: journals

Smad4: gatekeeper gene in head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Unchecked cell growth is a hallmark of cancer. During oncogenesis, cancerous cells become resistant to the TGF-β signaling pathway that usually keeps cell growth in check. The role of a critical mediator of this pathway, Smad4, in head and neck squamous cell carcinoma (HNSCC) remains unclear. In this issue of the JCI, Bornstein and colleagues report that Smad4 expression is decreased in malignant HNSCC and, surprisingly, also in normal-appearing buccal mucosa adjacent to HNSCC (see the related article, doi:10.1172/JCI38854). They also show that targeted conditional deletion of Smad4 in the head and neck epithelium ...
Source: Journal of Clinical Investigation - October 23, 2009 Category: Biomedical Science Authors: Murray Korc Source Type: journals

Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Further understanding of treatment resistance and interactions between bortezomib and docetaxel may provide novel approaches in managing HNSCC. PMID: 19850643 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 22, 2009 Category: Cancer & Oncology Authors: Chung CH, Aulino J, Muldowney NJ, Hatakeyama H, Baumann J, Burkey B, Netterville J, Sinard R, Yarbrough WG, Cmelak AJ, Slebos RJ, Shyr Y, Parker J, Gilbert J, Murphy BA Tags: Ann Oncol Source Type: journals

Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: IL1RN, MAL and MMP1 are prospective tumor diagnostic markers for HNSCC. MMP1 overexpression is the most promising marker, and its detection could help identify tumor cells in tissue or saliva. (Source: BMC Cancer)
Source: BMC Cancer - October 17, 2009 Category: Cancer & Oncology Authors: Benjamin LallemantAlexandre EvrardChristophe CombescureHeliette ChapuisGuillaume ChambonCaroline RaynalChristophe ReynaudOmar SabraDominique JoubertFrederic HollandeJean-Gabriel LallemantSerge LumbrosoJean-Paul Brouillet Source Type: journals

Establishment and characterization of patient tumor-derived head and neck squamous cell carcinoma xenografts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The overall purpose of this study was to establish human head and neck squamous cell carcinoma (HNSCC) xenografts in mice by transplantation of surgical tumor tissue and to characterize the growth, histologic and vascular properties of these xenografts. Primary surgical specimens of HNSCC were xenografted into eight-to-twelve week old severe combined immunodeficiency (SCID) mice. Histologic features of primary HNSCC specimens, initial and established xenografts were compared for tumors established from three different head and neck subsites, namely, oral cavity, larynx and base of tongue (one tumor per site). Growth ra...
Source: Cancer Biology and Therapy - October 16, 2009 Category: Cancer & Oncology Authors: Seshadri M, Merzianu M, Tang H, Rigual NR, Sullivan M, Loree TR, Popat SR, Repasky EA, Hylander BL Tags: Cancer Biol Ther Source Type: journals

Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 2001, we presented a Cox regression model that is able to predict survival of the newly diagnosed patient with head and neck squamous cell carcinoma (HNSCC). This model is based on the TNM classification and other important clinical variables such as age at diagnosis, sex, primary tumor site, and prior malignancies. We aim to improve this model by including comorbidity as an extra prognostic variable. Accurate prediction of the prognosis of the newly diagnosed patient with head and neck cancer can assist the physician in patient counseling, clinical decision-making, and quality maintenance.All patients with HNSCC of the...
Source: Head and Neck - October 12, 2009 Category: ENT & OMF Authors: Frank R. Datema, Marciano B. Ferrier, Marc P. van der Schroeff, Robert J. Baatenburg de Jong Source Type: journals

Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: CD39(+) Treg frequency and adenosine-mediated suppression are significantly increased in HNSCC patients. The adenosinergic pathway is involved in Treg-mediated immunosuppression in cancer and its attenuation could be a promising immunotherapeutic strategy for patients with HNSCC. (Clin Cancer Res 2009;15(20):6348-57). PMID: 19825957 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 12, 2009 Category: Cancer & Oncology Authors: Mandapathil M, Szczepanski MJ, Szajnik M, Ren J, Lenzner DE, Jackson EK, Gorelik E, Lang S, Johnson JT, Whiteside TL Tags: Clin Cancer Res Source Type: journals

Cross-Talk between Estrogen Receptor and Epidermal Growth Factor Receptor in Head and Neck Squamous Cell Carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: ERalpha and ERbeta were expressed in HNSCC, and stimulation with estrogen receptor ligands resulted in both cytoplasmic signal transduction and transcriptional activation. Estrogen receptor and EGFR cross-talk was observed. Collectively, these studies indicate that estrogen receptor and EGFR together may contribute to HNSCC development and disease progression. (Clin Cancer Res 2009;15(21):OF1-12). PMID: 19825947 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 12, 2009 Category: Cancer & Oncology Authors: Egloff AM, Rothstein ME, Seethala R, Siegfried JM, Grandis JR, Stabile LP Tags: Clin Cancer Res Source Type: journals

Prolonged facial edema is an indicator of poor prognosis in patients with head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Prolonged facial edema may reflect the underlying disease status, and it can be applied as a prognostic marker in patients with HNSCC. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00520-009-0754-8Authors Ming-Huang Chen, National Yang-Ming University Faculty of Medicine, School of Medicine Taipei TaiwanPeter Mu-Hsin Chang, National Yang-Ming University Faculty of Medicine, School of Medicine Taipei TaiwanPo-Min Chen, National Yang-Ming University Faculty of Medicine, School of Medicine Taipei TaiwanCheng-Hwai Tzeng, National Yang-Ming University Faculty of Medicine, Sch...
Source: Supportive Care in Cancer - October 12, 2009 Category: Cancer & Oncology Tags: Supportive Care in Cancer Source Type: journals

Transcriptional Activity of Human Epidermal Growth Factor Receptor Family and Angiogenesis Effectors in Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma and Correlation with Patient OutcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Locoregional recurrence is the most common failure pattern in patients with head and neck squamous cell carcinoma (HNSCC). We retrospectively identified 41 HNSCC patients with locoregional relapse and used kinetic reverse transcription-polymerase chain reaction (kRT-PCR) in order to study fresh-frozen tumour messenger RNA (mRNA) levels of the Human Epidermal growth factor family members HER1-4, the Vascular Endothelial Growth Factors (VEGFs) A, B, C, D, and their receptors VEGFR1, 2, 3. High VEGF-C and VEGFR3 tumour mRNA expression correlated with relapse beyond the primary locus (neck nodes or soft tissues, P<.05)....
Source: Journal of Oncology - October 7, 2009 Category: Cancer & Oncology Source Type: journals

The prognostic utility of haptoglobin genotypes in squamous cell carcinoma of the head and neckEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present data show that the Hp genotype is closely related to recurrence rate in patients with HNSCC. Patients with Hp 2-2 or 2-0 have greater locoregional recurrence and significantly increased HRs in multivariate analysis. The Hp genotype may be a prognostic factor in patients with HNSCC. Clin Chem Lab Med 2009;47:1277–83. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Nicotine-Induced Activation Of Head And Neck Cancers May Be Inhibited By CurcuminEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Curcumin, the compound that gives curry powder its yellow/orange color, may inhibit the adverse effects of nicotine in patients with head and neck cancer who continue to smoke. In a paper presented at the 2009 American Academy of Otolaryngology - Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & OTO EXPO in San Diego, researchers examined the effects of curcumin on head and neck squamous cell carcinoma (HNSCC) growths. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - October 6, 2009 Category: Cancer & Oncology Tags: Smoking / Quit Smoking Source Type: news

Does the expression of HPV16/18 E6/E7 in head and neck squamous cell carcinomas relate to their clinicopathological characteristics?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the expression of HPV16/18 E6/E7 in 71 cases of HNSCCs and investigated abnormalities of the p53 gene in 62 of these 71 cases. Expression of HPV16 E6/E7 was observed in 11 of the 71 cases (15.5%), while expression of HPV18 E6/E7 was not observed in any of the cases. Most of the HPV16 E6/E7-positive cases were histopathologically characterized by their verrucous or papillary structure and koilocytosis of the adjacent mucosa. There was no clear relationship between expression of HPV16 E6/E7 and tumor stage, prognosis or the positive rate of p53 abnormality. These results suggest that approximately 15% of HNSCCs a...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Yamakawa-Kakuta Y, Kawamata H, Doi Y, Fujimori T, Imai Y Tags: Int J Oncol Source Type: journals

Impaired T lymphocyte function increases tumorigenicity and decreases tumor latency in a mouse model of head and neck cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most frequent cancer worldwide. SCC is the most common malignant tumor of the oral cavity with over 35,000 cases and 8,000 deaths reported in the United States each year. Previous case studies have reported increased incidence of HNSCC in patients on immunosuppressive therapy for organ transplantation. The results of these studies indicate that effective immune surveillance is important for preventing emergence of HNSCC. HNSCC may also inhibit immune response to tumor cells, which may be responsible for progression. We previously reported induction of me...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Ku TK, Crowe DL Tags: Int J Oncol Source Type: journals

Diagnosis of second head and neck tumors in primary laryngeal SCC is an indicator of overall survival and not associated with poorer overall survival: A single centre study in 987 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study assessed the incidence of SPTs; the SPT diagnostic time lag; the impact on OS; and the mean annual risk.Nine hundred eighty seven consecutive patients treated for primary larynx SCC (1967-2004) were analyzed in this study. 96.3% and 91.4% of patients reached a minimum follow-up period of 3 and 5 years.Two hundred eight (21.1%) patients were diagnosed with SPTs. One hundred forty three (14.5%) patients developed upper aero-digestive tract (UAD)-SPTs, 83 (8.4%) were HNSCCs, 56 (5.7%) were lung, and 4 (0.41%) were esophageal-SPTs. Survival analysis demonstrated clear superior OS rates for the UAD-SPT (P < 0.008) an...
Source: Journal of Surgical Oncology - September 30, 2009 Category: Cancer & Oncology Authors: Ross Darius Farhadieh, Arash Salardini, Jia Lin Yang, Pamela Russell, Robert Smee Source Type: journals

Radiotherapy: IMRT reduces xerostomia and potentially improves QoLEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discusses outcomes after intensity-modulated radiation therapy and three-dimensional conventional radiotherapy among patients with head and neck squamous-cell carcinoma. (Source: Nature Clinical Practice Oncology)
Source: Nature Clinical Practice Oncology - September 29, 2009 Category: Cancer & Oncology Authors: Avraham Eisbruch Tags: News and Views Source Type: journals

Dendritic cells pulsed with GST-EGFR fusion protein: Effect in antitumor immunity against head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Overexpression of epidermal growth factor receptor (EGFR) is common in head and neck squamous cell carcinoma (HNSCC). Targeting EGFR is an effective approach to treat EGFR-positive HNSCC. However, the clinical benefits of the present EGFR-targeting agents are still limited in HNSCC patients.Recombinant glutathione-S-transferase (GST)-EGFR fusion protein was produced and purified. Dendritic cells (DCs) of C3H mice were pulsed with fusion protein. Mice were challenged with HNSCC cells before or after vaccination with these DCs, and the cytotoxic T-lymphocyte (CTL) response, interferon-[gamma] (IFN-[gamma]) secretion, tumor g...
Source: Head and Neck - September 28, 2009 Category: ENT & OMF Authors: Bei-Bei Yang, Hua Jiang, Jia Chen, Xing Zhang, Jing-Jia Ye, Jiang Cao Source Type: journals

Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Resistance to chemotherapy is a major limitation in the treatment of head and neck squamous cell carcinomas (HNSCCs), accounting for high mortality rates in patients. Here, we investigated the role of replication protein A (RPA) in cisplatin and etoposide resistance.We used 6 parental HNSCC cell lines. We also generated 1 cisplatin-resistant progeny subline from a parental cisplatin-sensitive cell line, to examine cisplatin resistance and sensitivity with respect to RPA2 hyperphosphorylation and cell-cycle response.Cisplatin-resistant HNSCC cell levels of hyperphosphorylated RPA2 in response to cisplatin were 80% to 90% gr...
Source: Head and Neck - September 28, 2009 Category: ENT & OMF Authors: Karoline C. Manthey, Jason G. Glanzer, Diana D. Dimitrova, Greg G. Oakley Source Type: journals

Early Postoperative Paclitaxel Followed by Concurrent Paclitaxel and Cisplatin With Radiation Therapy for Patients With Resected High-Risk Head and Neck Squamous Cell Carcinoma: Report of the Phase II Trial RTOG 0024 [Head and Neck Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Chemotherapy soon after surgery followed by concurrent chemoradiotherapy therapy was feasible; tolerance was in line with standard postoperative chemoradiotherapy; and this regimen led to excellent rates of locoregional control and disease-free survival. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 28, 2009 Category: Cancer & Oncology Authors: Rosenthal, Harris, Forastiere, Weber, Ridge, Myers, Garden, Kuettel, Sidhu, Schultz, Trotti, Ang Tags: Surgery, Radiation Head and neck Cancer Source Type: journals

Proinflammatory Mediators Upregulate Snail in Head and Neck Squamous Cell Carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: IL-1beta modulates Snail and thereby regulates COX-2-dependent E-cadherin expression in HNSCC. This is the first report indicating the role of Snail in the inflammation-induced promotion of EMT in HNSCC. This newly defined pathway for transcriptional regulation of E-cadherin in HNSCC has important implications for targeted chemoprevention and therapy. (Clin Cancer Res 2009;15(19):6018-27). PMID: 19789323 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - September 28, 2009 Category: Cancer & Oncology Authors: St John MA, Dohadwala M, Luo J, Wang G, Lee G, Shih H, Heinrich E, Krysan K, Walser T, Hazra S, Zhu L, Lai C, Abemayor E, Fishbein M, Elashoff DA, Sharma S, Dubinett SM Tags: Clin Cancer Res Source Type: journals

Nuclear NF-{kappa}B p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: NF-kappaB p65 (Ser276) phosphorylation by PKA promotes the malignant phenotype and holds potential as a therapeutic target in HNSCC. (Clin Cancer Res 2009;15(19):5974-84). PMID: 19789307 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - September 28, 2009 Category: Cancer & Oncology Authors: Arun P, Brown MS, Ehsanian R, Chen Z, Van Waes C Tags: Clin Cancer Res Source Type: journals

HER2 expression predicts improved survival in patients with cervical node–positive head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HER2 may be associated with longer survival in node-positive patients with HNSCC. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - September 28, 2009 Category: ENT & OMF Authors: Gary M. Tse, Kwok Hung Yu, Anthony W.H. Chan, Ann D. King, George G. Chen, Ka-Tak Wong, Raymond K.Y. Tsang, Amy B.W. Chan Tags: Head and neck Surgery Source Type: journals

Increased microsatellite instability and epigenetic inactivation of the hMLH1 gene in head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Promoter hypermethylation of the hMLH1 gene could be detected early in head and neck squamous carcinogenesis and may be associated with increased MSI and poor survival in HNSCC. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - September 28, 2009 Category: ENT & OMF Authors: Chunlai Zuo, Haihong Zhang, Horace J. Spencer, Emre Vural, James Y. Suen, Steven A. Schichman, Bruce R. Smoller, Mimi S. Kokoska, Chun-Yang Fan Tags: Head and neck Surgery Source Type: journals

Human papilloma virus in head and neck cancer: The need for a standardised assay to assess the full clinical importanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Recent studies have revealed an important and intriguing role for human papillomavirus (HPV) in head and neck squamous cell carcinoma (HNSCC). There are indications that the prevalence of HPV-positive HNSCC has recently increased, and genetic analyses point to a completely distinct class of HNSCCs. Most studies suggest that patients with this type of tumour have a better prognosis and some argue that an adjusted therapeutic approach is needed. One crucial point in the research of HNSCC–HPV involvement has often been neglected, which is the lack of a standardised assay to detect HPV. This has resulted in a consi...
Source: European Journal of Cancer - September 22, 2009 Category: Cancer & Oncology Authors: Boudewijn J.M. Braakhuis, Ruud H. Brakenhoff, Chris J.L.M. Meijer, Peter J.F. Snijders, C. René Leemans Tags: Current perspective Source Type: journals

Expression of Fibroblast Growth Factor Binding Protein in Head and Neck Cancer [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The expression of FGF-BP is statistically linked to the angiogenesis of HNSCC, suggesting that FGF-BP participates in the angiogenesis of HNSCC. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - September 21, 2009 Category: ENT & OMF Authors: Li, W., Wang, C., Juhn, S. K., Ondrey, F. G., Lin, J. Tags: Oncology, Head & neck Cancer, Skin Cancer, Otolaryngology/ Head & neck Surgery, Neoplasms of Head & neck Original Article Source Type: journals

Comparison of Clinical and Pathological Staging in Head and Neck Squamous Cell Carcinoma: Results From Intergroup Study ECOG 4393/RTOG 9614 [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Both staging methods are useful in predicting survival, whereas information gained at neck dissection regarding nodal metastases provides some refinement in prognostic results. These findings demonstrate the need for enhanced methods of tumor assessment and apparent benefit of data gathered at neck dissection for accurate disease assessment and stratification. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - September 21, 2009 Category: ENT & OMF Authors: Koch, W. M., Ridge, J. A., Forastiere, A., Manola, J. Tags: Oncology, Head & neck Cancer, Skin Cancer, Otolaryngology/ Head & neck Surgery, Neoplasms of Head & neck, Prognosis/ Outcomes Original Article Source Type: journals