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What medical and economical benefit has the examination of the helicobacter pylori population via urea respiratory test in primary diagnosticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A record from the CRD Health Techology Assessment Database. Published in June 2009. (Source: Gastroenterology and Liver Diseases Specialist Library - Stomach)
Source: Gastroenterology and Liver Diseases Specialist Library - Stomach - November 20, 2009 Category: Gastroenterology Source Type: organizations

What medical and economical benefit has the examination of the helicobacter pylori population via urea respiratory test in primary diagnosticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A record from the CRD Health Techology Assessment Database. Published in June 2009. (Source: Gastroenterology and Liver Diseases Specialist Library - Diagnostic procedures)
Source: Gastroenterology and Liver Diseases Specialist Library - Diagnostic procedures - November 20, 2009 Category: Gastroenterology Source Type: organizations

Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in PakistanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Helicobacter pylori (H. pylori) infection is known to be associated with a spectrum of gastroduodenal diseases. We studied the association of H. pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU). Methods: H. pylori infection established by both rapid urease test and histology were studied. The cagA and vacA allelic status was determined by polymerase chain reaction (PCR). Sequencing of vacA i1 and i2 PCR product was carried out. Results: ...
Source: BMC Gastroenterology - November 20, 2009 Category: Gastroenterology Authors: Javed YakoobShahab AbidZaigham AbbasWasim JafriZubair AhmadRashida AhmedMuhammad Islam Source Type: journals

Ranitidine is unable to maintain gastric pH levels above 4 in septic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Intravenous ranitidine was unable to maintain gastric pH above 4 in septic patients. All cases in the ranitidine group in whom pH remained above 4 had gastric hypotrophy or atrophy. Pantoprazole successfully maintained pH levels above 4. (Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Cristina B. Terzi Coelho, Desanka Dragosavac, João S. Coelho Neto, Ciro G. Montes, Fábio Guerrazzi, Nelson Adami Andreollo Tags: Electronic Articles Source Type: journals

Frequency of Helicobacter pylori vacA genotypes in Iranian patients with gastric and duodenal ulcerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrated that vacA slml is common genotype of H. pylori in patients with peptic ulcer and the vacA allele s1 of this bacterium is associated with ulcer. (Source: Journal of Infection and Public Health)
Source: Journal of Infection and Public Health - November 19, 2009 Category: Global & Universal Authors: M.H. Salari, M.H. Shirazi, M. Ahmmadi Hadaiti, N. Abrahimi Daryani Tags: Original Articles Source Type: journals

Gastric ghrelin in relation to gender, stomach topography and Helicobacter pylori in dyspeptic patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: An increase in gastric ghrelin levels at the stage of non-atrophic gastritis in H pylori positive patients, especially in those infected with cagA(-) strains, can exert a gastroprotective effect. PMID: 19916170 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Stec-Michalska K, Malicki S, Michalski B, Peczek L, Wisniewska-Jarosinska M, Nawrot B Tags: World J Gastroenterol Source Type: journals

Association between Helicobacter pylori seropositivity and digestive tract cancers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma. PMID: 19916178 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Wu IC, Wu DC, Yu FJ, Wang JY, Kuo CH, Yang SF, Wang CL, Wu MT Tags: World J Gastroenterol Source Type: journals

Etiologic factors of gastric cardiac adenocarcinoma among men in Taiwan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Working or exercising after meals and H pylori infection increase the risk of GCA, but higher intakes of rice, fresh vegetables and fruits reduce the risk. PMID: 19916179 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Chen MJ, Wu DC, Lin JM, Wu MT, Sung FC Tags: World J Gastroenterol Source Type: journals

Intermolecular cross-linking of monomers in H. pylori Na{+}/H{+} antiporter NhaA at dimer interface inhibits antiporter activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We previously showed that the Na+/H+ antiporter of Helicobacter pylori (HPNhaA) forms an oligomer in a native membrane of Escherichia coli, and conformational changes of oligomer occur between monomers of the oligomer during ion transport. In the current study, we use Blue Native PAGE to show that HPNhaA forms a dimer. Cysteine-scanning mutagenesis of residues 55 to 61 in a putative β-sheet region of loop1 and subsequent functional analyses revealed that the Q58C mutation resulted in an intermolecular disulfide bond. G56C, I59C, and G60C were found to be cross-linked by bifunctional cross-linkers. Furt...
Source: BJ Energy - November 19, 2009 Category: Biochemistry Authors: A Karasawa, K Mitsui, M Matsushita, H Kanazawa Tags: BJ Energy Source Type: journals

Functional Divergence of Helicobacter pylori Related to Early Gastric CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)
Source: Journal of Proteome Research - November 18, 2009 Category: Biochemistry Tags: article Source Type: journals

Structure of Helicobacter pyloril-asparaginase at 1.4 Å resolutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bacterial l-asparaginases have been used in the treatment of childhood acute lymphoblastic leukaemia for over 30 years. Their therapeutic effect is based on their ability to catalyze the conversion of l-asparagine, an essential amino acid in certain tumours, to l-aspartic acid and ammonia. Two l-asparaginases, one from Escherichia coli and the other from Erwinia chrysanthemi, have been widely employed in clinical practice as anti-leukaemia drugs. However, l-asparaginases are also able to cause severe side effects owing to their intrinsic glutaminase activity. Helicobacter pylori l-asparaginase (HpA) has been reported to ...
Source: Acta Crystallographica Section D - November 17, 2009 Category: Biochemistry Authors: Dhavala, P.Papageorgiou, A.C. Tags: l-asparaginases active site leukaemia treatment therapeutic enzymes research papers Source Type: journals

Iron deficiency, Helicobacter infection and gastritis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite elegant regulatory mechanisms, iron deficiency anemia (IDA) remains one of the most common nutritional deficiencies of mankind. Iron deficiency is the result of an interplay between increased host requirements, limited external supply, and increased blood loss. When related to increased physiologic needs associated with normal development, iron deficiency is designated physiologic or nutritional. By contrast, pathological iron deficiency, with the exception of gross menorrhagia, is most often the result of gastrointestinal disease associated with abnormal blood loss or malabsorption. If gastroenterologic evalua...
Source: Acta Haematologica - November 13, 2009 Category: Hematology Authors: Hershko C, Ronson A Tags: Acta Haematol Source Type: journals

Recognition of tRNAGln by Helicobacter pylori GluRS2--a tRNAGln-specific glutamyl-tRNA synthetaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Accurate aminoacylation of tRNAs by the aminoacyl-tRNA synthetases (aaRSs) plays a critical role in protein translation. However, some of the aaRSs are missing in many microorganisms. Helicobacter pylori does not have a glutaminyl-tRNA synthetase (GlnRS) but has two divergent glutamyl-tRNA synthetases: GluRS1 and GluRS2. Like a canonical GluRS, GluRS1 aminoacylates tRNAGlu1 and tRNAGlu2. In contrast, GluRS2 only misacylates tRNAGln to form Glu-tRNAGln. It is not clear how GluRS2 achieves specific recognition of tRNAGln while rejecting the two H. pylori tRNAGlu isoacceptors. Here, we show that GluRS2 recognizes major identi...
Source: Nucleic Acids Research - November 13, 2009 Category: Research Authors: Chang, K.-M., Hendrickson, T. L. Tags: RNA Source Type: journals

Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues‡Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Medicinal Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 13, 2009 Category: Chemistry Tags: article Source Type: journals

Health News of the DayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day:5 Pathogens Linked to Risk for Stroke: Chlamydia pneumoniae, Helicobacter pylori, CMV, herpes simplex viruses 1 and 2 http://bit.ly/3UUisRFDA looks for ways to regulate drug promotion on Twitter, Wikipedia, blogs and other social media http://bit.ly/1fJ1X85% of winter deaths are caused by influenza http://bit.ly/3tU1oRHow to avoid falling victim to a hospital mistake - CNN http://bit.ly/1dUL1TVideo: Top 10 Tips for Residency...
Source: Clinical Cases and Images - November 13, 2009 Category: Journals (General) Tags: Health News of the Day Source Type: info

Vital Signs: Risks: 5 Pathogens Linked to Risk for StrokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The lead author of a study said low-level infection and inflammation in vessel walls might be leading to disease. (Source: NYT > Health)
Source: NYT > Health - November 12, 2009 Category: Consumer Health News Authors: By RONI CARYN RABIN Tags: Stroke Bacteria helicobacter pylori (Bacterium) Herpes Viruses Medicine and Health Source Type: news

Anti-Infective Strategies of the Future: Is there Room for Species-Specific Antibacterial Agents?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Broad-spectrum antibiotics, directed against conserved bacterial targets, are the mainstay of antibacterial therapy. Increasing resistance, however, demands new strategies. Over time a number of therapeutic concepts have evolved, starting out with the use of polyclonal antisera, which were rapidly replaced by the easier to use antibiotics. Other concepts, such as immunotherapy, radioimmunotherapy, anti-virulence agents, phage therapy and others are under evaluation and often limited in application. In the discovery process of new antibiotics in the pharmaceutical industry quite a number of new agents have emerged, whic...
Source: Current Pharmaceutical Design - November 10, 2009 Category: Drugs & Pharmacology Authors: Then RL, Sahl HG Tags: Curr Pharm Des Source Type: journals

Infectious Burden and Risk of Stroke: The Northern Manhattan Study [Original Contribution]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A quantitative weighted index of infectious burden was associated with risk of first stroke in this cohort. Future studies are needed to confirm these findings and to further define optimal measures of infectious burden as a stroke risk factor.Published online November 9, 2009 (doi:10.1001/archneurol.2009.271). (Source: Archives of Neurology)
Source: Archives of Neurology - November 9, 2009 Category: Neurology Authors: Elkind, M. S. V., Ramakrishnan, P., Moon, Y. P., Boden-Albala, B., Liu, K. M., Spitalnik, S. L., Rundek, T., Sacco, R. L., Paik, M. C. Tags: Bacterial Infections, Viral Infections, Neurology, Cerebrovascular Disease, Stroke, Infectious Diseases Original Contribution Source Type: journals

Pernicious anemia: new insights from a gastroenterological point of view.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pernicious anemia (PA) is a macrocytic anemia that is caused by vitamin B(12) deficiency, as a result of intrinsic factor deficiency. PA is associated with atrophic body gastritis (ABG), whose diagnosis is based on histological confirmation of gastric body atrophy. Serological markers that suggest oxyntic mucosa damage are increased fasting gastrin and decreased pepsinogen I. Without performing Schilling's test, intrinsic factor deficiency may not be proven, and intrinsic factor and parietal cell antibodies are useful surrogate markers of PA, with 73% sensitivity and 100% specificity. PA is mainly considered a disease ...
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Lahner E, Annibale B Tags: World J Gastroenterol Source Type: journals

Neither genotype nor the gastric colonization site of Helicobacter pylori are predictive factors for the development of erosive esophagitis in patients with peptic ulcer disease, 1 year after eradicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The incidence of erosive esophagitis in peptic ulcer patients who had their H. pylori eradicated was 19%. No correlation was found between the gastric site colonized by H. pylori or strains expressing CagA and the prevention or development of erosive esophagitis in patients with peptic ulcer disease, 1 year after infection eradication.CONTEXTO: É controverso se a infecção pelo Helicobacter pylori é um fator de proteção ou de predisposição para o desenvolvimento da doença de refluxo gastroesofágico. Cepas mais virulentas tais como as que expressam a citotoxina CagA e o local no estômago de infecção...
Source: Arquivos de Gastroenterologia - November 6, 2009 Category: Gastroenterology Source Type: journals

Could gastric histology be a useful marker for making decision on Helicobacter pylori eradication therapy in patients with dyspepsia?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Since upper gastrointestinal endoscopy is part of the functional dyspepsia investigation and serology for anti-CagA antibody is not available in daily clinical practice, by biopsying gastric mucosa we would only be able to selectively apply H. pylori eradication therapy for those with histology that best correlate with virulent infecting strains (moderate or severe gastritis) - around ¼ of our study patients with dyspepsia.CONTEXTO: O benefício da terapia de erradicação do H. pylori como parte do tratamento da dispepsia funcional ainda é uma questão em aberto. Diferenças na distribuição geográfica, a ...
Source: Arquivos de Gastroenterologia - November 6, 2009 Category: Gastroenterology Source Type: journals

[Correspondence] Gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As Henk Hartgrink and colleagues note in their excellent Seminar, Helicobacter pylori is a major risk factor for gastric cancer, although not all populations with high rates of H pylori infection have a raised incidence of the disease. In addition to differences in H pylori genotypes, modulation by external factors will also probably affect the role of H pylori in carcinogenesis. Among these external factors, some researchers have included proton-pump inhibitors (PPI). (Source: LANCET)
Source: LANCET - November 6, 2009 Category: Journals (General) Authors: Francisco José Fernández-Fernández, Pascual Sesma Tags: Correspondence Source Type: journals

Characterization of NikR-responsive promoters of urease and metal transport genes of Helicobacter mustelae.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the H. mustelae NikR regulator directly controls nickel-responsive regulation of ureases and metal transporters. The improved consensus NikR operator sequence allows the prediction of additional NikR targets in Helicobacter genomes, as demonstrated by the identification of a new nickel-repressed outer membrane protein in H. mustelae. PMID: 19894125 [PubMed - as supplied by publisher] (Source: Biometals)
Source: Biometals - November 6, 2009 Category: Biochemistry Authors: Stoof J, Kuipers EJ, van Vliet AH Tags: Biometals Source Type: journals

Antimicrobial Activity of Aminoreductone against Helicobacter pyloriEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Agricultural and Food Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - November 5, 2009 Category: Food Science Tags: article Source Type: journals

Upper gastrointestinal bleeding in children with haemophilia: a clinical significance of Helicobacter pylori infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary. For patients with haemophilia, gastrointestinal (GI) bleeding is a life-threatening complication and can be caused by the Helicobacter pylori infection. Among children with haemophilia who had visited with GI bleeding, the prevalence of H. pylori infection and the recurrence rate after H. pylori eradication was investigated. Seven children with haemophilia A with hematemesis (age: 5.3[ndash]17.0 years) were evaluated for the causes of GI bleeding and the detection of H. pylori. Gastroendoscopy was done to find the bleeding focus and for further evaluation including rapid urease test and mucosal biopsy. Four patien...
Source: Haemophilia - November 5, 2009 Category: Hematology Authors: B. H. CHOE, J. Y. KIM, J. H. LEE, J. M. KIM, M. A. CHU, S. M. CHO, K. S. LEE Source Type: journals

NMR Solution Structure of HP0827 (O25501_HELPY) from Helicobacter pylori: Model of the Possible RNA-binding SiteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The HP0827 protein is an 82-residue protein identified as a putative ss-DNA-binding protein 12RNP2 Precursor from Helicobacter pylori. Here, we have determined 3D structure of HP0827 using Nuclear Magnetic Resonance. It has a ferredoxin-like fold, β1–1–β2–β3–2–β4 (; -helix and β; β-sheet) and ribonucleoprotein (RNP) motifs which are thought to be important in RNA binding. By using structural homologues search and analyzing electrostatic potential of surface, we could compared HP0827 with other RNA-binding proteins (sex-lethal, T-cell restricted intracellular antig...
Source: Journal of Biochemistry - November 4, 2009 Category: Biochemistry Authors: Jang, S.-B., Ma, C., Lee, J.-Y., Kim, J.-H., Park, S. J., Kwon, A.-R., Lee, B.-J. Tags: Regular Papers Source Type: journals

Simultaneous inference of biological networks of multiple species from genome-wide data and evolutionary information: a semi-supervised approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Motivation: The existing supervised methods for biological network inference work on each of the networks individually based only on intra-species information such as gene expression data. We believe that it will be more effective to use genomic data and cross-species evolutionary information from different species simultaneously, rather than to use the genomic data alone. Results: We created a new semi-supervised learning method called Link Propagation for inferring biological networks of multiple species based on genome-wide data and evolutionary information. The new method was applied to simultaneous reconstruction of t...
Source: Bioinformatics - November 4, 2009 Category: Bioinformatics Authors: Kashima, H., Yamanishi, Y., Kato, T., Sugiyama, M., Tsuda, K. Tags: DATA AND TEXT MINING Source Type: journals

Quadruple therapy with ecabet sodium, omeprazole, amoxicillin and metronidazole is effective for eradication of Helicobacter pylori after failure of first-line therapy (KDOG0201 Study)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Quadruple therapy including ecabet sodium is useful as second-line eradication treatment for H. pylori. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - November 4, 2009 Category: Drugs & Pharmacology Authors: W. Koizumi, S. Tanabe, K. Nakatani, K. Ishido, K. Nishimura, M. Azuma, T. Ae, T. Sasaki, K. Higuchi, C. Katada, N. Nakayama, K. Saigenji Source Type: journals

Validation of Diagnostic Tests for Helicobacter pylori with Regard to Grade of Atrophic Gastritis and/or Intestinal MetaplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Any one of biopsy-based tests or serology was found to be excellent for identifying current H. pylori infection among individuals without AG or IM and/or younger patients ( (Source: Helicobacter)
Source: Helicobacter - November 4, 2009 Category: Gastroenterology Authors: Cheol Min Shin, Nayoung Kim, Hye Seung Lee, Hee Eun Lee, Sang Hyub Lee, Young Soo Park, Jin Hyuk Hwang, Jin-Wook Kim, Sook-Hyang Jeong, Dong Ho Lee, Hyun Chae Jung, In Sung Song Tags: ORIGINAL ARTICLES Source Type: journals

The Modified Sequential Treatment Regimen Containing Levofloxacin for Helicobacter pylori Eradication in TurkeyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Sequential therapy using "rabeprazole and amoxicillin 7 days followed by rabeprazole, metronidazole and levofloxacin for 7 days" is a new regimen with acceptable eradication rates in naïve patients in Turkey. Further modifications in the dose or duration of this new sequential therapy might increase its effectiveness as both first and second line treatment. (Source: Helicobacter)
Source: Helicobacter - November 4, 2009 Category: Gastroenterology Authors: Ahmet Aydin, Nevin Oruc, Ilker Turan, Omer Ozutemiz, Muge Tuncyurek, Ahmet Musoglu Tags: ORIGINAL ARTICLES Source Type: journals

Helicobacter pylori Multiplex SerologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: With its high-throughput and simultaneous detection abilities, H. pylori multiplex serology appears suited as tool for large seroepidemiologic studies assessing H. pylori prevalence, antibody patterns, and associations with specific diseases. (Source: Helicobacter)
Source: Helicobacter - November 4, 2009 Category: Gastroenterology Authors: Angelika Michel, Tim Waterboer, Manfred Kist, Michael Pawlita Tags: ORIGINAL ARTICLES Source Type: journals

Cost-Effectiveness of Eradication of Helicobacter pylori in Gastric Cancer Survivors After Endoscopic Resection of Early Gastric CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this selective population with very high risk of developing gastric cancer, H. pylori eradication should be considered for reimbursement with priority to prevent subsequent cancer and also reduce health care cost. (Source: Helicobacter)
Source: Helicobacter - November 4, 2009 Category: Gastroenterology Authors: Dong Wook Shin, Young Ho Yun, Il Ju Choi, Eurah Koh, Sang Min Park Tags: ORIGINAL ARTICLES Source Type: journals

Detection of Helicobacter hepaticus in Human Bile Samples of Patients with Biliary DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Helicobacter hepaticus may closely associate with diseases of the liver and biliary tract in humans. (Source: Helicobacter)
Source: Helicobacter - November 4, 2009 Category: Gastroenterology Authors: Toshihide Hamada, Kenji Yokota, Kiyoshi Ayada, Kazuyuki Hirai, Tomoari Kamada, Ken Haruma, Kazuaki Chayama, Keiji Oguma Tags: ORIGINAL ARTICLES Source Type: journals

Reactive Nitrogen Species Mediate DNA Damage in Helicobacter pylori-Infected Gastric MucosaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Helicobacter pylori infection can induce inflammatory cells infiltration, which evokes DNA damage of gastric epithelial cells through ROS and RNS production. 8-NG might be a more sensitive biomarker than 8-OHdG for H. pylori-induced DNA damage in gastric mucosa. (Source: Helicobacter)
Source: Helicobacter - November 4, 2009 Category: Gastroenterology Authors: Masaki Katsurahara, Yoshinao Kobayashi, Motoh Iwasa, Ning Ma, Hiroyuki Inoue, Naoki Fujita, Kyosuke Tanaka, Noriyuki Horiki, Esteban C. Gabazza, Yoshiyuki Takei Tags: ORIGINAL ARTICLES Source Type: journals

Bioaccumulation of Amylose-Like Glycans by Helicobacter pyloriEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This work shows that under specific environmental conditions, H. pylori expresses a phase-variable cell-surface [alpha]-(1[rarr]4)-glucose moiety. (Source: Helicobacter)
Source: Helicobacter - November 4, 2009 Category: Gastroenterology Authors: José A. Ferreira, Cristiana Pires, Marina Paulo, Nuno F. Azevedo, M. Rosário Domingues, Maria João Vieira, Mario A. Monteiro, Manuel A. Coimbra Tags: ORIGINAL ARTICLES Source Type: journals

LTA 252GG and GA Genotypes are Associated with Diffuse-Type Noncardia Gastric Cancer Risk in the Japanese PopulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The LTA 252 genotype is associated with noncardia gastric cancer of diffuse type in Japan and interacted with radiation dose. (Source: Helicobacter)
Source: Helicobacter - November 4, 2009 Category: Gastroenterology Authors: Gen Suzuki, Harry Cullings, Saeko Fujiwara, Shinsuke Matsuura, Takeshi Kishi, Waka Ohishi, Masazumi Akahoshi, Tomonori Hayashi, Eiichi Tahara Tags: ORIGINAL ARTICLES Source Type: journals

Host Single Nucleotide Polymorphisms of MMP-9 −1562/TIMP-1 372 Have Gender Differences in the Risk of Gastric Intestinal Metaplasia After Helicobacter pylori InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The host MMP-9 [minus]1562/TIMP-1 372 SNPs had gender differences in the risk of IM after H. pylori infection, and could possibly serve as a host factor to identify the risk group harboring gastric precancerous changes after H. pylori infection. (Source: Helicobacter)
Source: Helicobacter - November 4, 2009 Category: Gastroenterology Authors: Kuei-Hsiang Hung, Hunt-Wen Hung, Hsiao-Bai Yang, Cheng-Chan Lu, Jiunn-Jong Wu, Bor-Shyang Sheu Tags: ORIGINAL ARTICLES Source Type: journals

Modulation of Activation-Induced Cytidine Deaminase by Curcumin in Helicobacter pylori-Infected Gastric Epithelial CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Nonbactericidal concentrations of curcumin downregulated H. pylori-induced AID expression in gastric epithelial cells, probably via the inhibition of NF-[kappa]B pathway. Hence, curcumin can be considered as a potential chemopreventive candidate against H. pylori-related gastric carcinogenesis. (Source: Helicobacter)
Source: Helicobacter - November 4, 2009 Category: Gastroenterology Authors: Syed Faisal Haider Zaidi, Takeshi Yamamoto, Alaa Refaat, Kanwal Ahmed, Hiroaki Sakurai, Ikuo Saiki, Takashi Kondo, Khan Usmanghani, Makoto Kadowaki, Toshiro Sugiyama Tags: ORIGINAL ARTICLES Source Type: journals

Serum Levels of Leptin As Marker For Patients At High Risk of Gastric CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Serological screening for gastric cancer (GC) may reduce mortality. However, optimal serum markers for advanced gastric precursor lesions are lacking.Aim: To evaluate in a case[ndash]control study whether serum leptin levels correlate with intestinal metaplasia (IM) and can serve as a tool to identify patients at high risk for GC.Materials and Methods: Cases were patients with a previous diagnosis of IM or dysplasia, controls were patients without such a diagnosis. All patients underwent endoscopy. Fasting serum was collected for the measurement of leptin, pepsinogens I/II, gastrin, and Helicobacter pylori. Rec...
Source: Helicobacter - November 4, 2009 Category: Gastroenterology Authors: Lisette G. Capelle, Annemarie C. de Vries, Jelle Haringsma, Ewout W. Steyerberg, Caspar W. N. Looman, Nicole M. A. Nagtzaam, Herman van Dekken, Frank ter Borg, Richard A. de Vries, Ernst J. Kuipers Tags: ORIGINAL ARTICLES Source Type: journals

Reduced microRNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Poor expression of microRNAs (miRs) reportedly plays an important role in gastric carcinogenesis. Large-scale microarray assays have indicated that there is significant down-regulation of miR-218 in gastric cancer. miR-218 also was decreased specifically in human papillomavirus-positive cell lines, cervical lesions, and cervical cancer tissues and in bronchial airway epithelium in smokers. However, its role in carcinogenesis remains unclear, especially in Helicobacter pylori (H. pylori)-associated gastric cancer.miR-218 levels were evaluated in 20 noncardia gastric cancer tissues, in 10 H. pylori-infected and 8 uninfected ...
Source: Cancer - November 4, 2009 Category: Cancer & Oncology Authors: Caiping Gao, Zhiyu Zhang, Wenzhong Liu, Shudong Xiao, Weiqi Gu, Hong Lu Source Type: journals

Methods to monitor autophagy in H. pylori vacuolating cytotoxin A (VacA)-treated cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Helicobacter pylori is a gram negative pathogen that infects at least half of the world's population and is associated not only with gastric cancer but also with other diseases such as gastritis and peptic ulcers. Indeed, H. pylori is considered the single most important risk factor for the development of gastric cancer. The vacuolating cytotoxin VacA, secreted by H. pylori, promotes intracellular survival of the bacterium and modulates host immune responses. In a recent study, we reported that VacA induces autophagy. Multilamellar autophagosomes are detected in gastric epithelial cells that are distinct from the large...
Source: Autophagy - November 3, 2009 Category: Cytology Authors: Raju D, Jones NL Tags: Autophagy Source Type: journals

LAC and LOAD: 4-Drug Regimen Better at Eliminating H. Pylori Than Standard 3-Drug TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
LOAD (levofloxacin, omeprazole, nitazoxanide, and doxycycline) is more effective at eradicating Helicobacter pylori than LAC (lansoprazole, amoxicillin, and clarithromycin). Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 2, 2009 Category: Consumer Health News Tags: Gastroenterology Source Type: news

LAC and LOAD: 4-Drug Regimen Better at Eliminating H Pylori Than Standard 3-Drug TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
LOAD (levofloxacin, omeprazole, nitazoxanide, and doxycycline) is more effective at eradicating Helicobacter pylori than LAC (lansoprazole, amoxicillin, and clarithromycin). Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - November 2, 2009 Category: Gastroenterology Tags: Gastroenterology Source Type: info

Gastric cancer in iran: epidemiology and risk factors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although the global incidence of gastric cancer has been decreased dramatically in recent decades, it is the most common cancer in north and northwest Iran. The wide variation in incidence across different geographical areas and higher proportion of cardia cancer are two main characteristics of gastric cancer in Iran. Current investigations indicate that a high prevalence of H.pylori infection, high dietary intake of salt and smoking are the main environmental factors of gastric cancer in Iran. Gastroesophageal reflux disease is another contributing factor in populations with a higher incidence of gastric cardia cancer...
Source: Archives of Iranian Medicine - November 1, 2009 Category: Middle East Health Authors: Malekzadeh R, Derakhshan MH, Malekzadeh Z Tags: Arch Iran Med Source Type: journals

Effect of resveratrol on helicobacter pylori-induced interleukin-8 secretion, reactive oxygen species generation and morphological changes in human gastric epithelial cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inflammatory cytokine interleukin-8 (IL-8) and reactive oxygen species (ROS) overexpressed in the gastric mucosa when exposed to Helicobacter pylori, defined as a class I carcinogen. Moreover, infection with H. pylori leads to morphological changes in co-cultured cells known as hummingbird phenomenon along with increased motility. Resveratrol, a highly abundant polyphenol in red grapes, has shown anti-inflammatory, anti-cancer, cardioprotective and neuroprotective activities. However, the effect of resveratrol in H. pylori-infected cells has not been investigated. The present study was, therefore, aimed to evaluate the...
Source: Biological and Pharmaceutical Bulletin - November 1, 2009 Category: Drugs & Pharmacology Authors: Zaidi SF, Ahmed K, Yamamoto T, Kondo T, Usmanghani K, Kadowaki M, Sugiyama T Tags: Biol Pharm Bull Source Type: journals

Regulation of cellular immunity prevents Helicobacter pylori-induced atherosclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we demonstrated that H. pylori infection promoted atherogenesis in heterozygous apoe(+/ --) ldlr(+/--) mice. The male mice were fed with high fat diet from the age of 6 weeks. At the age of 16 weeks, development of atherosclerotic lesions was observed in the H. pylori-infected mice, and it seemed to be associated with an elevation of Th1-immune response against H. pylori origin-heat shock protein 60 (Hp-HSP60) and an increment of transendothelial migration of T cells. Subcutaneous immunisation with Hp-HSP60 or H. pylori eradication with antibiotics significantly reduced the progression of atherosclerosis, ac...
Source: Lupus - November 1, 2009 Category: Rheumatology Authors: Ayada K, Yokota K, Hirai K, Fujimoto K, Kobayashi K, Ogawa H, Hatanaka K, Hirohata S, Yoshino T, Shoenfeld Y, Matsuura E, Oguma K Tags: Lupus Source Type: journals

Screening practices for infectious diseases among Burmese refugees in Australia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Increasing numbers of refugees from Burma (Myanmar) are resettling in Western countries. We performed a retrospective study of 156 Burmese refugees at an Australian teaching hospital. Of those tested, Helicobacter pylori infection affected 80%, latent tuberculosis 70%, vitamin D deficiency 37%, and strongyloidiasis 26%. Treating these diseases can prevent long-term illness. PMID: 19891864 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - November 1, 2009 Category: Infectious Diseases Authors: Chaves NJ, Gibney KB, Leder K, O'Brien DP, Marshall C, Biggs BA Tags: Emerg Infect Dis Source Type: journals

Early Eradication of H. pylori May Prevent Gastric CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Among patients with peptic ulcer disease, early eradication of Helicobacter pylori protects against the development of gastric cancer, Dr. Chun-Ying Wu and colleagues. In a retrospective cohort study of more than 80,000 patients throughout China who were hospitalized for peptic ulcer disease, those who received therapy to eradicate H. pylori soon after recovery showed a risk of gastric cancer similar to that in the general population. In contrast, patients who did not receive such therapy until years later had a higher risk of developing gastric cancer. (Source: Family Practice News)
Source: Family Practice News - November 1, 2009 Category: Primary Care Authors: MARY ANN MOON Tags: Digestive Disorders Source Type: news

Dysphagia associated with an elevated amylase levelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 34-year-old woman with a history of gastric ulcers, GERD, and asthma presented for endoscopic evaluation of recurrent dyspepsia and 2 months of dysphagia for solids. She denied odynophagia, weight loss, early satiety, and fever. Her medications included omeprazole and albuterol. Physical examination was unremarkable. Laboratory data were pertinent only for a mildly elevated serum amylase levels of 212 U/L and 180 U/L (normal range 30-110 U/L) with normal lipase levels on consecutive phlebotomies. An EGD revealed extrinsic compression of the distal esophagus (A) and a clean-based antral ulcer; testing for Helicobacter pyl...
Source: Gastrointestinal Endoscopy - October 31, 2009 Category: Gastroenterology Authors: Joseph M. McKinley, James S. Barthel, Tawfik N. Chami Tags: At the Focal Point Source Type: journals

Clinicopathological Features and Prognostic Factors of Proximal Gastric Carcinoma in a Population with High Helicobacter pylori Prevalence: A Single-Center, Large-Volume Study in KoreaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions PGC has increased in incidence with the respective decline in H. pylori prevalence in Korea. Survival was worse for patients with PGC than for those with DGC, regardless of curative respectability. PGC is often diagnosed at more advanced stage than other gastric cancers, and therefore early detection is critical for successful treatment. Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-009-0785-xAuthors Jun Chul Park, Yonsei University College of Medicine Department of Internal Medicine, Institute of Gastroenterology Seoul KoreaYong Chan Lee, Yonsei Universi...
Source: Annals of Surgical Oncology - October 31, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals