Hepatitis B
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Frequency of antibodies against the etiologic agents of acquired imunodeficiency syndrome, syphilis, hepatitis B and C, and Chagas' disease in patients with rheumatic diseases treated with anti-tumor necrosis factor
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CONCLUSION: The frequency of seropositivity for different infectious diseases in patients under anti-TNF therapy is low. Individuals with positive serology for hepatitis C deserve close attention. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals
Primary antiphospholipid syndrome and hepatitis B and C infectionsEmail this article to a colleague.
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CONCLUSION: A small percentage of patients with primary APS had positive serology for hepatitis B and C, and all represented cases post-vaccine or serology scar. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals
Dynavax Completes Enrollment Of First Cohort Of Patients In Phase 1b Clinical Trial For Hepatitis B TherapyEmail this article to a colleague.
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Dynavax Technologies Corporation (NASDAQ: DVAX) announced today that enrollment has been completed for the first of three cohorts of patients receiving DV-601 hepatitis B therapy in a Phase 1b clinical trial. The safety profile of patients in the first cohort met pre-specified criteria for dose escalation and the second cohort has been opened for enrollment. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news
Toward Explaining Why Hepatitis B Hits Men Harder Than WomenEmail this article to a colleague.
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Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news
Toward Explaining Why Hepatitis B Hits Men Harder Than WomenEmail this article to a colleague.
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Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication. (Source: Liver Disease / Hepatitis News From Medical News Today)
Source: Liver Disease / Hepatitis News From Medical News Today - November 20, 2009 Category: Gastroenterology Tags: Liver Disease / Hepatitis Source Type: news
Dynavax Completes Enrollment Of First Cohort Of Patients In Phase 1b Clinical Trial For Hepatitis B TherapyEmail this article to a colleague.
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Dynavax Technologies Corporation (NASDAQ: DVAX) announced today that enrollment has been completed for the first of three cohorts of patients receiving DV-601 hepatitis B therapy in a Phase 1b clinical trial. The safety profile of patients in the first cohort met pre-specified criteria for dose escalation and the second cohort has been opened for enrollment. Dynavax expects to report top-line data from this trial in the second half of 2010. (Source: Liver Disease / Hepatitis News From Medical News Today)
Source: Liver Disease / Hepatitis News From Medical News Today - November 20, 2009 Category: Gastroenterology Tags: Liver Disease / Hepatitis Source Type: news
Why Hepatitis B Hits Men Harder Than WomenEmail this article to a colleague.
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Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news
Why Hepatitis B Hits Men Harder Than WomenEmail this article to a colleague.
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Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication. (Source: Liver Disease / Hepatitis News From Medical News Today)
Source: Liver Disease / Hepatitis News From Medical News Today - November 20, 2009 Category: Gastroenterology Tags: Liver Disease / Hepatitis Source Type: news
Do we need an 'in-house' neutralization assay for confirmation of hepatitis B surface antigen? Answers from a tertiary care hospital in IndiaEmail this article to a colleague.
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Conclusion: The enzyme immunoassay-based 'in-house' HBsAg neutralization assay is a feasible alternative to the commercial HBsAg confirmatory assay. This technique is easily adaptable, cost-effective and reliable for the confirmation of HBsAg in a low resource setting, enhancing the overall quality of HBsAg screening. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 20, 2009 Category: Gastroenterology Authors: Gnanadurai J Fletcher, Manu Gnanamony, Joel David, Ashrafali M Ismail, Thenmozhi Subramani, Priya Abraham Source Type: journals
GAVI Alliance Drives Down Pentavalent Vaccine Costs, Data ShowsEmail this article to a colleague.
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The "co-ordinated buying policy" of the GAVI Alliance has driven down "[t]he price of a vaccine that helps babies fight off killer diseases," according to data released by the group, Reuters reports. In 2010, the price of pentavalent vaccine, which protects against Hib (Haemophilus influenzae type b), diphtheria, whooping cough, tetanus and hepatitis B, will fall "below $3.0 - a drop of almost $0. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news
GAVI Alliance Drives Down Pentavalent Vaccine Costs, Data ShowsEmail this article to a colleague.
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The "co-ordinated buying policy" of the GAVI Alliance has driven down "[t]he price of a vaccine that helps babies fight off killer diseases," according to data released by the group, Reuters reports. In 2010, the price of pentavalent vaccine, which protects against Hib (Haemophilus influenzae type b), diphtheria, whooping cough, tetanus and hepatitis B, will fall "below $3.0 - a drop of almost $0. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news
Why hepatitis is harder on men?Email this article to a colleague.
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Researchers in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication........ (Source: Medicineworld.org: New Article Alert)
Source: Medicineworld.org: New Article Alert - November 19, 2009 Category: Consumer Health News Source Type: info
ENGERIX-B (Hepatitis B Vaccine (Recombinant)) Injection, Suspension [GlaxoSmithKline Biologicals SA]Email this article to a colleague.
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Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 19, 2009 Category: Drugs & Pharmacology Source Type: organizations
Hepatitis B markers and vaccination-induced protection rate among Albanian pregnant women in Greece.Email this article to a colleague.
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Hepatitis B has long been a serious public health problem both in Greece and in Albania. In the February 2009 issue of World Journal of Gastroenterology, Resuli et al presented the interesting epidemiological data concerning hepatitis B virus infection in Albania. The results of this study were discussed and several data from our similar research were provided.
PMID: 19916183 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Elefsiniotis IS, Vezali E, Brokalaki H, Tsoumakas K Tags: World J Gastroenterol Source Type: journals
Evidence for the insufficient evaluation and undertreatment of chronic hepatitis B infection in a predominantly low-income and immigrant populationEmail this article to a colleague.
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Conclusions: After the diagnosis of HBV infection, few patients in our population received laboratory evaluation to determine eligibility for HBV treatment. Furthermore, only a small percentage received HBV treatment. Further research needs to be done to validate these findings in other populations and understand barriers to receiving HBV treatment. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Chin W Jung, Jennifer Tan, Nelly Tan, Melissa N Kuo, Ashwin Ashok, Samantha J Eells, Loren G Miller Source Type: journals
What are 'true normal' liver stiffness values using FibroScan®?: a prospective study in healthy living liver and kidney donors in South KoreaEmail this article to a colleague.
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To identify the normal range of liver stiffness (LS) values by recruiting healthy living liver and kidney donors in South Korea. Liver stiffness measurement (LSM) was performed in 69 healthy living liver and kidney donors who were admitted for transplantation. None of the subjects suffered from diabetes mellitus, hypertension, hepatitis B virus infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or metabolic syndrome. LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available liver histology, eight showed normal liver histology and four showed liver steatosis of (Source: Liver International)
Source: Liver International - November 19, 2009 Category: Gastroenterology Authors: Seung Up Kim, Gi Hong Choi, Woong Kyu Han, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Jin Sub Choi, Seung Choul Yang, Eun Hee Choi, Sang Hoon Ahn, Kwang-Hyub Han, Chae Yoon Chon Source Type: journals
Introduction of human papillomavirus (HPV) vaccination in Belgium, 2007-2008Email this article to a colleague.
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This paper documents the progress of human papillomavirus (HPV) vaccine introduction in Belgium. Information on vaccine use is based on sales statistics and reimbursement claims. From November 2007 to November 2008, the National Institute for Health and Disability Insurance reimbursed the HPV vaccine for girls aged between 12-15 years. In December 2008, the age limit was extended to include girls up to the age of 18. In November 2008, the total number of HPV vaccines sold exceeded 530,000 doses. The number of vaccines reimbursed in Belgium, for the period November 2007-November 2008, corresponds to the amount required to f...
Source: Eurosurveillance latest news - November 19, 2009 Category: Infectious Diseases Source Type: journals
Insulin resistance is associated with liver stiffness in HIV/HCV co-infected patientsEmail this article to a colleague.
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Conclusion:
IR is associated with LS in patients co-infected with HIV/HCV. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Merchante, N, Rivero, A, de los Santos-Gil, I, Merino, D, Marquez, M, Lopez-Ruz, M A, Rodriguez-Bano, J, del Valle, J, Camacho, A, Sanz-Sanz, J, Macias, J, Perez-Camacho, I, Gomez-Mateos, J, Moro, A, Pineda, J A Tags: Hepatology Source Type: journals
Toward explaining why hepatitis B hits men harder than womenEmail this article to a colleague.
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(American Chemical Society) Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 18, 2009 Category: Global & Universal Source Type: news
Survey of both hepatitis B virus (HBsAg) and hepatitis C virus (HCV-Ab) coinfection among HIV positive patientsEmail this article to a colleague.
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Conclusion There was a significant correlation between coinfection with HCV and HBV and/or both among HIV-positive patients depending on different variables including sex, age, occupation, marital status ,exposure to risk factors.(p (Source: Virology Journal)
Source: Virology Journal - November 18, 2009 Category: Virology Authors: Mohsen MohammadiGholamreza TaleiAli SheikhianFarzad EbrahimzadeYadollah PourniaEhsan GhasemiHadis Boroun Source Type: journals
Targeting TGF-[beta]1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitisEmail this article to a colleague.
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Intestinal fibrosis and stricture formation are major complications of inflammatory bowel disease (IBD), for which there are currently few effective treatments. We sought to investigate whether targeting transforming growth factor-beta1 (TGF-[beta]1), a key profibrotic mediator, with a peptide-based virus-like particle vaccine would be effective in suppressing intestinal fibrosis by using a mouse model of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced chronic colitis.The vaccine was prepared by inserting a peptide derived from mouse TGF-[beta]1 into a carrier hepatitis B core antigen using gene recombination methods. C...
Source: Inflammatory Bowel Diseases - November 18, 2009 Category: Gastroenterology Authors: Yanbing Ma, Qingdong Guan, Aiping Bai, Carolyn R. Weiss, China-Li Hillman, Allan Ma, Gang Zhou, Gefei Qing, Zhikang Peng Source Type: journals
Hepatitis B virus genotypes and evolutionary profiles of blood donors from Northwest region of ChinaEmail this article to a colleague.
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Hepatitis B virus (HBV) is prevalent in China and screening of blood donors is mandatory. Up to now, ELISA has been universally used by the China blood bank. However, this strategy has sometimes failed due to the high frequency of nucleoside acid mutations. Understanding HBV evolution and strain diversity could help devise a better screening system for blood donors. However, this kind of information in China, especially in the northwest region, is lacking. In the present study, serological markers and the HBV DNA load of 11 samples from blood donor candidates from northwest China were determined. The HBV strains were most ...
Source: Virology Journal - November 17, 2009 Category: Virology Authors: Xing-bin HuQiao-hong YueXian-qing ZhangXue-qing XuWen YinYao-zhen ChenXiao-dong ChengLiu YangShi-jie Mu Source Type: journals
Outcome Poor in HBV Patients Waitlisted for Liver TransplantEmail this article to a colleague.
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Patients with hepatitis B virus (HBV) infection waitlisted for liver transplantation face a lower probability of receiving a transplant and a higher probability of dying without a transplant. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 16, 2009 Category: Consumer Health News Tags: Gastroenterology Source Type: news
Cellular Pharmacology of the Anti-Hepatitis B Virus Agent ss-L-2',3'-Didehydro-2',3'-dideoxy-N4-hydroxycytidine: Relevance for the Activation in HepG2 Cells.Email this article to a colleague.
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ss-L-2',3'-didehydro-2',3'-dideoxy-N(4)-hydroxycytidine (L-Hyd4C) was demonstrated to be an effective and highly selective inhibitor of hepatitis B virus (HBV) replication in HepG2.2.15 cells (ED50=0.03 muM; CD50 =2,500 muM). In the present study we investigated the intracellular pharmacology of tritiated L-Hyd4C in HepG2 cells. [(3)H]L-Hyd4C was shown to be phospho-rylated extensively and rapidly to the 5'-mono-, 5'-di- and 5'-triphosphate derivatives. Other metabolites deriving from a reduction or removal of the NHOH-group of L-Hyd4C could not be detected, although both reactions were described as the primary catabol...
Source: Antimicrobial Agents and Chemotherapy - November 16, 2009 Category: Microbiology Authors: Matthes E, Bünger H Tags: Antimicrob Agents Chemother Source Type: journals
Sexual Transmission Blamed for High HBV Infection RateEmail this article to a colleague.
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Horizontal transmission, probably by sexual contact, appears to be to blame for perpetuating the high prevalence of hepatitis B virus (HBV) infection in pregnant women here, according to local researchers presenting at the 5th Asia Pacific Congress in Maternal Fetal Medicine. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 12, 2009 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Source Type: news
Occult Hepatitis B Virus Infection Increases Hepatocellular Carcinogenesis by Eight Times in Patients With Non-B, Non-C Liver Cirrhosis: A Cohort StudyEmail this article to a colleague.
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This study takes a look. Journal of Viral Hepatitis (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - November 12, 2009 Category: Gastroenterology Tags: Gastroenterology Source Type: info
Low‐Abundance Drug Resistance Mutations: Extending the HIV Paradigm to Hepatitis B VirusEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 200, Issue 11, Page 1798-1799, 1 December 2009. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 12, 2009 Category: Infectious Diseases Tags: article CORRESPONDENCE Source Type: journals
PEDIARIX (Diphtheria And Tetanus Toxoids And Acellular Pertussis Adsorbed, Hepatitis B (Recombinant) And Inactivated Poliovirus Vaccine Combined) Injection, Suspension [GlaxoSmithKline Biologicals SA]Email this article to a colleague.
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Updated Date: Nov 12, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 12, 2009 Category: Drugs & Pharmacology Source Type: organizations
Invited Commentary: Evaluating Vaccination Programs Using Genetic Sequence Data.Email this article to a colleague.
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Genomic data will become an increasingly important component of epidemiologic studies in coming years. The authors of the accompanying Journal article, van Ballegooijen et al. (Am J Epidemiol. 2009;XXX(XX):000-000), are to be commended for attempting to use the coalescent analysis of viral sequence data to evaluate a hepatitis B vaccination program. Coalescent theory attempts to link the phylogenetic history of populations with rates of population growth and decline. In particular, under certain assumptions, a reduction in genetic diversity can be interpreted as a reduction in disease incidence. However, the authors of...
Source: Am J Epidemiol - November 12, 2009 Category: Epidemiology Authors: Halloran ME, Holmes EC Tags: Am J Epidemiol Source Type: journals
Molecular Sequence Data of Hepatitis B Virus and Genetic Diversity After Vaccination.Email this article to a colleague.
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The effect of vaccination programs on transmission of infectious disease is usually assessed by monitoring programs that rely on notifications of symptomatic illness. For monitoring of infectious diseases with a high proportion of asymptomatic cases or a low reporting rate, molecular sequence data combined with modern coalescent-based techniques offer a complementary tool to assess transmission. Here, the authors investigate the added value of using viral sequence data to monitor a vaccination program that was started in 1998 and was targeted against hepatitis B virus in men who have sex with men in Amsterdam, the Neth...
Source: Am J Epidemiol - November 12, 2009 Category: Epidemiology Authors: van Ballegooijen WM, van Houdt R, Bruisten SM, Boot HJ, Coutinho RA, Wallinga J Tags: Am J Epidemiol Source Type: journals
A mathematical model to study the effect of hepatitis B virus vaccine and antivirus treatment among the Canadian Inuit populationEmail this article to a colleague.
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This study will use a mathematical model to compare
the roles of vaccination and therapy to predict future prevalence and incidence among the Canadian Inuit population for the
next 50 years. We applied a mathematical model developed by Medley et al. (Nat Med 7(5):619–624, 2001), combined with data
on hepatitis B incidence, prevalence, and vaccination coverage, to predict trends of hepatitis B virus (HBV) among the Inuit
population over the next 50 years. The current estimated prevalence of HBV is 6.04% and the incidence is 3.4/100,000 persons
among Canadian Inuit. If HBV vaccination coverage levels of 47.2...
Source: European Journal of Clinical Microbiology & Infectious Diseases - November 11, 2009 Category: Microbiology Tags: European Journal of Clinical Microbiology & Infectious Diseases Source Type: journals
Generation of Full-Length Functional Antibody against PreS2 of Hepatitis B Virus in Hepatic Cells In Vitro from Bicistrons Mediated by Gutless AdenovirusEmail this article to a colleague.
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(Source: BioDrugs)
Source: BioDrugs - November 11, 2009 Category: Drugs & Pharmacology Authors: Yin, YuexiangLin, FangZhuang, QiangLiu, LiQian, Cheng Tags: Original Research Article Source Type: journals
Management of Hepatitis B Virus Reactivation in Patients with Hematological Malignancies Treated with ChemotherapyEmail this article to a colleague.
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Conclusions Essential to the management of patients with hematological malignancies undergoing chemotherapy are surveillance and prophylaxis
of HBV infection together with prompt administration of nucleoside/nucleotide analogs in cases of reactivation and/or seroreversion.
Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s15010-009-9019-1Authors
D. Francisci, University of Perugia Division of Infectious Diseases, Dept. of Experimental Medicine and Biochemical Science Ospedale “Santa Maria della Misericordia”, P.zzle Menghini 1 06132 Perugia ItalyF. Falcinelli, University of Perugia Sect...
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals
Tubal Ligation Reversal and Preoperative Blood TestsEmail this article to a colleague.
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One of the first questions potential patients ask before scheduling their tubal tubal ligation reversal is "Are there any preoperative test that need to be done before my tubal reversal?" Chapel Hill Tubal Reversal Center requires our patients to have the following blood test results before having their reversal of tubal ligation: Complete Blood Count, HIV-1 antibody, Hepatitis B surface antigen, and Hepatitis C antibody. Testing should be performed within 7 days of scheduling surgery, but not more than 90 days before your actual tubal reversal surgery date. The blood tests can be ordered by your physician or at a local la...
Source: Tubal Ligation Reversal News - November 11, 2009 Category: Reproduction Medicine Source Type: organizations
Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infectionEmail this article to a colleague.
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In this study phenacetin, a probe drug (1 g for men and 0.85 g for women orally), was applied for the detection of sulfotransferase 1A1 (SULT1A1) and cytochrome P4501A2 (CYP1A2) activities in 82 healthy participants and 148 HCC, 106 cirrhosis, and 41 chronic hepatitis B patients. In addition, a prospective cohort study for susceptibility to HCC was performed in 205 patients with cirrhosis secondary to chronic HBV infection. Compared with the healthy participants, S.1A1 activity increased by 9.7-fold in the HCC patients (P < 0.01). CYP1A2 activity did not significantly differ between the healthy participants and HCC patient...
Source: Cancer Science - November 10, 2009 Category: Cancer & Oncology Authors: Xiang-Rui Wang, Zeng-Qiang Qu, Xiao-Dong Li, Hai-Lin Liu, Ping He, Bei-Xiong Fang, Jie Xiao, Wei Huang, Meng-Chao Wu Source Type: journals
Hepatitis B Not a Player in Pancreatic CancerEmail this article to a colleague.
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Hepatitis B virus infection does not appear to increase the risk for pancreatic cancer, as has been previously suggested. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 9, 2009 Category: Consumer Health News Tags: Gastroenterology Source Type: news
Virological pattern of hepatitis B infection in an HIV-positive man with fatal fulminant hepatitis B: a case reportEmail this article to a colleague.
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Conclusion:
This case report provides clinical evidence of a possible association between the rapid spread of highly replicative escape mutants and the development of fulminant hepatitis in a heavily immunocompromised patient. Virological surveillance of severe acute hepatitis B may be important in establishing an early treatment strategy involving antiviral drugs capable of preventing liver failure, especially in individuals for whom liver transplantation is not accepted as a standard indication. (Source: BioMed Central)
Source: BioMed Central - November 9, 2009 Category: Journals (General) Authors: Sabrina BagaglioLuca AlbarelloPriscilla BiswasCaterina Uberti-FoppaClaudio FortisGiulia Morsica Source Type: journals
Lamivudine maintenance beyond one year after HBeAg seroconversion is a major factor for sustained virologic response in HBeAg-positive chronic hepatitis BEmail this article to a colleague.
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Conclusion: The lamivudine-induced virologic response was durable in patients under 40 years old and those receiving lamivudine for more than 12 months after HBeAg clearance or seroconversion. Age and additional treatment were major predictive factors for SVR. (HEPATOLOGY 2010.) (Source: Hepatology)
Source: Hepatology - November 9, 2009 Category: Internal Medicine Authors: Hyun Woong Lee, Heon Ju Lee, Jae Seok Hwang, Joo Hyun Sohn, Jae Young Jang, Ki Jun Han, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Yong Han Paik, Chun Kyon Lee, Kwan Sik Lee, Chae Yoon Chon, Kwang-Hyub Han Source Type: journals
Hepatitis B virus reactivation and role of antiviral prophylaxis in lymphoma patients with past hepatitis B virus infection who are receiving chemoimmunotherapyEmail this article to a colleague.
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The objective of the current study was to determine the prevalence of past HBV infection in patients with lymphoma and its relevance in terms of HBV-related complications.The authors reviewed 430 patients with lymphoma from May 2006 to May 2008.Among the 430 patients, 233 had both the HBsAg and HBcAb tests performed, whereas 197 had only the HBsAg test performed. Among those with both tests performed, 34.3% (80 of 233) were HBcAb positive only. Of these 80 patients, 58 had a concomitant HBV DNA level test, which was positive in 3 (5.2%). Of the 67 patients with past and 26 with chronic HBV infection who received chemothera...
Source: Cancer - November 7, 2009 Category: Cancer & Oncology Authors: Yu Xuan Koo, Daniel S. W. Tan, Iain B. Tan, Miriam Tao, Wan Cheng Chow, Soon Thye Lim Source Type: journals
Comparison between hepatitis B and C epidemiological profiles at a public institution in São Paulo, BrazilEmail this article to a colleague.
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CONTEXTO: As hepatites virais constituem doença de notificação compulsória e apresentam grande importância em nosso meio devido à elevada prevalência. OBJETIVO: Comparar o perfil epidemiológico dos casos confirmados de hepatites B e C notificados no Núcleo de Vigilância Epidemiológica do Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, no período entre janeiro de 2004 e abril de 2007. MATERIAL: Os resultados foram analisados através do teste do qui ao quadrado. RESULTADOS: Observou-se 112 casos confirmados de hepatite B e 651 de hepatite C. Houve predominância do sexo masculino dentre os ...
Source: Arquivos de Gastroenterologia - November 6, 2009 Category: Gastroenterology Source Type: journals
Analysis of the Efficacy of Treatment With Peginterferon Alpha-2a and Ribavirin in Patients Coinfected With Hepatitis B Virus And Hepatitis C VirusEmail this article to a colleague.
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Investigators examined the virologic features of patients coinfected with HBV and HCV and the efficacy of combination therapy with peginterferon alpha-2a and ribavirin in these patients. Liver International (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - November 6, 2009 Category: Gastroenterology Tags: Gastroenterology Source Type: info
Differential gene expression profiles of hepatocellular carcinomas associated or not with viral infection.Email this article to a colleague.
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Chronic hepatitis B (HBV) and C (HCV) virus infections are the most important factors associated with hepatocellular carcinoma (HCC), but tumor prognosis remains poor due to the lack of diagnostic biomarkers. In order to identify novel diagnostic markers and therapeutic targets, the gene expression profile associated with viral and non-viral HCC was assessed in 9 tumor samples by oligo-microarrays. The differentially expressed genes were examined using a z-score and KEGG pathway for the search of ontological biological processes. We selected a non-redundant set of 15 genes with the lowest P value for clustering samples...
Source: Braz J Med Biol Res - November 6, 2009 Category: Research Authors: Bellodi-Privato M, Kubrusly MS, Stefano JT, Soares IC, Wakamatsu A, Oliveira AC, Alves VA, Bacchella T, Machado MC, D'Albuquerque LA Tags: Braz J Med Biol Res Source Type: journals
Bone Mineral Density and Serum Levels of Soluble Tumor Necrosis Factors, Estradiol, and Osteoprotegerin in Postmenopausal Women with Cirrhosis after Viral Hepatitis.Email this article to a colleague.
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Conclusions: This study shows that bone mass and bone resorption rates do not differ between postmenopausal women with viral cirrhosis and healthy postmenopausal controls and suggests that viral cirrhosis does not appear to increase the risk of osteoporosis in these women. High serum estradiol and OPG concentrations may contribute to preventing the bone loss associated with viral cirrhosis in postmenopausal women.
PMID: 19897681 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: González-Calvin JL, Mundi JL, Casado-Caballero FJ, Abadia AC, Martin-Ibañez JJ Tags: J Clin Endocrinol Metab Source Type: journals
Long-term efficacy of interferon alpha therapy on hepatitis B viral replication in patients with chronic hepatitis B: A meta-analysis.Email this article to a colleague.
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CONCLUSIONS: In conclusion, the results of this meta-analysis indicate that IFN increases the incidence of HBeAg seroclearance and HBsAg serorclearance after long-term follow-up of three to seven years.
PMID: 19900483 [PubMed - as supplied by publisher] (Source: Antiviral Research)
Source: Antiviral Research - November 6, 2009 Category: Virology Authors: Yang YF, Zhao W, Xia HM, Zhong YD, Huang P, Wen J Tags: Antiviral Res Source Type: journals
Increased expression of inhibitor of apoptosis proteins, survivin and XIAP, in non-small cell lung carcinoma.Email this article to a colleague.
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In conclusion, the overexpression of survivin in the majority of NSCLCs together with the abundant or upregulated expression of HBXIP and XIAP suggest that tumours are endowed with resistance against a variety of apoptosis-inducing conditions.
PMID: 19885569 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Krepela E, Dankova P, Moravcikova E, Krepelova A, Prochazka J, Cermak J, Schützner J, Zatloukal P, Benkova K Tags: Int J Oncol Source Type: journals
HBV Reduces Recurrence-Free Survival After Surgery for Hepatocellular CarcinomaEmail this article to a colleague.
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In cirrhotic patients, hepatitis B virus (HBV) infection is associated with a poorer long-term prognosis after hepatectomy for hepatocellular carcinoma, according to Italian researchers. Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - November 5, 2009 Category: Gastroenterology Tags: General Surgery Source Type: info
Fixed-Dose Tenofovir/Emtricitabine Safe and Effective Option for the Treatment of Patients With Chronic Hepatitis B Infection and Decompensated Liver DiseaseEmail this article to a colleague.
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Capsule Summary - The safety profile and virologic, biochemical, and clinical efficacy outcomes were similar among patients treated with 48 weeks of tenofovir/emtricitabine, tenofovir monotherapy, or entecavir monotherapy in this randomized phase II study. (Source: Clinical Care Options Hepatitis - HBV)
Source: Clinical Care Options Hepatitis - HBV - November 5, 2009 Category: Infectious Diseases Source Type: journals
Low Factor V Levels Signal Poor Prognosis With Hepatitis B-Induced Acute Liver FailureEmail this article to a colleague.
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Factor V level on day 3 of hospitalization was strongly associated with survival in HBV-associated acute liver failure, with levels of 0% to 10% among those who died and 7% to 25% for survivors. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 5, 2009 Category: Consumer Health News Tags: Gastroenterology Source Type: news
Genome-wide DNA methylation profiles in precancerous conditions and cancersEmail this article to a colleague.
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Alterations of DNA methylation, which result in chromosomal instability and silencing of tumor-related genes, are among the most consistent epigenetic changes observed in human cancers. Analysis of tissue specimens has revealed that DNA methylation alterations participate in multistage carcinogenesis, even from the early and precancerous stages, especially in association with chronic inflammation and/or persistent viral infection, such as chronic hepatitis or liver cirrhosis resulting from infection with hepatitis B or C virus. DNA methylation alterations can account for the histological heterogeneity and clinicopathologic...
Source: Cancer Science - November 5, 2009 Category: Cancer & Oncology Authors: Yae Kanai Source Type: journals
Rationale against Preoperative Screening for HIV in Polish Hospitals: A Prevalence Study of Anti‐HIV in Contrast to Anti–Hepatitis C Virus and Hepatitis B Surface Antigen • Email this article to a colleague.
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We describe the prevalence of anti–human immunodeficiency virus (anti‐HIV) among a sample of 1,652 surgical and gynecologic patients in Polish hospitals, contrasting it with the prevalence of hepatitis B surface antigen (HBsAg) and anti–hepatitis C virus (anti‐HCV) to assess the rationale for preoperative testing. No anti‐HIV–positive samples were found; the prevalence of anti‐HCV was 0.9%, slightly higher than the prevalence of HBsAg of 0.6%. Universal preoperative screening of hospital patients for HIV is currently not warranted according to the Centers for Disease Control and Prevention guidelines. However...
Source: Infect Control Hosp Epidemiol Latest Issue - November 4, 2009 Category: Epidemiology Tags: article Concise Communication Source Type: journals
