High Intensity Focused Ultrasound Therapy This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

Noninvasive Renal Sympathetic Denervation by Extracorporeal High-Intensity Focused Ultrasound in a Pre-Clinical Canine Model
ConclusionsEffective RSD was successfully achieved by using the extracorporeal HIFU method in canines. Thus, noninvasive HIFU may be further explored as an important and novel strategy for RSD. (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - May 20, 2013 Category: Cardiology Source Type: research

Toward real‐time availability of 3D temperature maps created with temporally constrained reconstruction
ConclusionThe RT‐TCR algorithm offers an approach to obtaining large coverage 3D temperature maps in real‐time for monitoring MR‐guided high intensity focused ultrasound treatments. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - May 13, 2013 Category: Radiology Authors: Nick Todd, Jaya Prakash, Henrik Odéen, Josh Bever, Allison Payne, Phaneendra Yalavarthy, Dennis L. Parker Tags: Full paper Source Type: research

Image‐directed, tissue‐preserving focal therapy of prostate cancer: a feasibility study of a novel deformable mr‐us registration system
ConclusionNon‐rigid MR‐US registration is feasible, efficient and can locate lesions on ultrasound.The process has potential for improved accuracy of focal treatments, and improved diagnostic sampling strategies for prostate cancer.Further work on whether deformable MR‐US registration impacts on efficacy is required. (Source: BJU International)
Source: BJU International - May 9, 2013 Category: Urology & Nephrology Authors: L Dickinson, Y Hu, HU Ahmed, C Allen, AP Kirkham, M Emberton, D Barratt Tags: Urological Oncology Source Type: research

Center of Excellence for HIFU Surgical Ablation Technology
SonaCare Medical, a global leader in minimally invasive HIFU technologies, announced today that it has partnered with University College London (UCL) to create a HIFU Center of Excellence.05/03/2013 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - May 3, 2013 Category: Cancer & Oncology Source Type: news

SonaCare to incorporate SmartTarget into its HIFU system
High-intensity focused ultrasound (HIFU) developer SonaCare Medical plans to (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - May 1, 2013 Category: Radiology Source Type: news

Ultrasonic atomization: A mechanism of tissue fractionation.
Abstract High intensity focused ultrasound (HIFU) can be used to atomize liquid by creating a fountain on the surface exposed to air. The mechanism of atomization can be most accurately described by the cavitation-wave hypothesis wherein a combination of capillary waves excited on the liquid surface with cavitation beneath the surface produces a fine spray. Here, we show experimentally that a free tissue surface can also be atomized resulting in erosion of tissue from the surface. A 2-MHz spherically focused transducer operating at linearly predicted in situ intensities up to 14,000 W/cm(2) was focused at ex vivo b...
Source: Physica Medica - May 1, 2013 Category: Physics Authors: Simon JC, Sapozhnikov OA, Khokhlova VA, Wang YN, Crum LA, Bailey MR Tags: J Acoust Soc Am Source Type: research

High Intensity Focused Ultrasound Transducer
We provide semi-custom, modular, and pure custom ultrasonic transducer products for High Intensity Focused Ultrasound applications. Each solution is designed for your specific applications. (Source: PhysicsWeb Products and Press)
Source: PhysicsWeb Products and Press - April 25, 2013 Category: Physics Source Type: news

Ultrasound line-by-line scanning method of spatial-temporal active cavitation mapping for high-intensity focused ultrasound.
Abstract This paper presented an ultrasound line-by-line scanning method of spatial-temporal active cavitation mapping applicable in a liquid or liquid filled tissue cavities exposed by high-intensity focused ultrasound (HIFU). Scattered signals from cavitation bubbles were obtained in a scan line immediately after one HIFU exposure, and then there was a waiting time of 2s long enough to make the liquid back to the original state. As this pattern extended, an image was built up by sequentially measuring a series of such lines. The acquisition of the beamformed radiofrequency (RF) signals for a scan line was synchro...
Source: Ultrasonics - April 24, 2013 Category: Physics Authors: Ding T, Zhang S, Fu Q, Xu Z, Wan M Tags: Ultrasonics Source Type: research

Amplitude modulated chirp excitation to reduce grating lobes and maintain ultrasound intensity at the focus of an array.
In this study, a 5-MHz, 9-element, 1.25mm inter-elemental spacing linear array was excited by a sinusoidal waveform, a conventional linear chirp, and a modified linear chirp. Both chirps spanned the -3-dB bandwidth of the transducer. The conventional chirp was a broadband signal with a linear sweep of frequencies between 2.5 and 7.5MHz, with all frequency components excited with equal amplitude. The modified chirp signal also swept the frequencies between 2.5 and 7.5MHz, but the amplitude was weighted such that the edges (low and high frequencies of the band) were excited with more energy than the center of the band. In si...
Source: Ultrasonics - April 16, 2013 Category: Physics Authors: Karunakaran CP, Oelze ML Tags: Ultrasonics Source Type: research

Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study
Huizhong Cui, Ti Zhang, and Xinmai Yang Laser-enhanced cavitation during high intensity focused ultrasound (HIFU) was studied in vivo using a small animal model. Laser light was employed to illuminate the sample concurrently with HIFU radiation. The resulting cavitation was detected with a passive cavitation detector. The in vivo measurem ... [Appl. Phys. Lett. 102, 133702 (2013)] published Wed Apr 3, 2013. (Source: Applied Physics Letters)
Source: Applied Physics Letters - April 11, 2013 Category: Physics Source Type: research

Impact of Medical Treatment on Long-Term Results after Surgical Ablation of Atrial Fibrillation in Cardiac Surgical Patients.
Conclusion: AF treatment with HIFU ablation during concomitant cardiac surgery is a safe and effective procedure for restoring SR, especially in patients with AF and especially in patients with a smaller left atrial diameter. No significant difference was noted between the antiarrhythmic and non drug groups regarding restoration and maintaining SR; however, better results were achieved by those taking a β-blocker. PMID: 23558224 [PubMed - as supplied by publisher] (Source: Annals of Thoracic and Cardiovascular Surgery)
Source: Annals of Thoracic and Cardiovascular Surgery - April 5, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Feyrer R, Ballazhi F, Seitz T, Weyand M, Harig F Tags: Ann Thorac Cardiovasc Surg Source Type: research

MRI‐based prediction of pulsed high‐intensity focused ultrasound effect on tissue transport in rabbit muscle
Conclusion:Successful p‐HIFU treatment was mainly correlated to tissue heating. Tissue transport properties following treatment success would result in improved contact between drug and targets in both time and space. MRI is the key to controlling treatment by means of thermometry and also monitoring efficacy by means of T2‐weighted imaging. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - April 1, 2013 Category: Radiology Authors: Brian E. O'Neill, Howard Q. Vo, Hongwei Shao, Christof Karmonik, Xiaobo Zhou, King C. Li Tags: Original Research Source Type: research

High-intensity Focused Ultrasound
Focused ultrasound uses an ultrasound beam generated from a large transducer or array of transducers, which is focused to a small focal point (similar to a magnifying glass) to exert an effect in deep tissue, with the intent of sparing surrounding tissues from the effect. Focused ultrasound can also be performed through the skin or natural orifices, usually with the transducer coupled to the surface with fluid. Incisions and needles are not typically needed. Focused ultrasound has many current and potential medical applications ranging from creating transient cellular membrane permeability to thermal heating for tumor and ...
Source: Ultrasound Clinics - April 1, 2013 Category: Radiology Authors: George A. Holland, Oleg Mironov, Jean-Francois Aubry, Arik Hananel, Jeremy B. Duda Source Type: research

Noninvasive Renal Sympathetic Denervation by Extracorporeal High-Intensity Focused Ultrasound in a Pre-Clinical Canine Model
Conclusions: Effective RSD was successfully achieved by using the extracorporeal HIFU method in canines. Thus, noninvasive HIFU may be further explored as an important and novel strategy for RSD. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - March 28, 2013 Category: Cardiology Authors: Qifeng Wang, Rui Guo, Shunkang Rong, Gang Yang, Que Zhu, Yonghong Jiang, Changming Deng, Dichuan Liu, Qi Zhou, Qi Wu, Shunhe Wang, Jun Qian, Qi Wang, Han Lei, Tong-Chuan He, Zhibiao Wang, Jing Huang Tags: PRE-CLINICAL RESEARCH Source Type: research

First Successful Case of Non‐Invasive In Utero Treatment of TRAP Sequence by High Intensity Focused Ultrasound
We present a case of twin reversed arterial perfusion (TRAP) sequence, in which non‐invasive blood flow occlusion in the acardiac fetus was successfully achieved by means of HIFU exposure from outside the maternal abdomen. HIFU was applied to the umbilical cord entered into the body of the acardiac fetus at 13 and 17 gestational weeks. The HIFU intensity was set at approximately 2,300 W/cm2 and 4,600 W/cm2 respectively, with exposure periods of 10 s. As color Doppler did not show the blood supply to the acardiac fetus after the latter HIFU exposure, we thought complete occlusion of target vessels was achieved. Delivery w...
Source: Ultrasound in Obstetrics and Gynecology - March 26, 2013 Category: Radiology Authors: Takashi Okai, Kiyotake Ichizuka, Junichi Hasegawa, Ryu Matsuoka, Masamitsu Nakamura, Kazuhisa Shimodaira, Akihiko Sekizawa, Miki Kushima, Shinichirou Umemura Tags: Case Report Source Type: research

Respiration based steering for high intensity focused ultrasound liver ablation
Conclusions:A system for performing HIFU steering during ablation of the liver with breathing motion is presented and shown to achieve results equivalent to ablation performed with breath‐holding. Magn Reson Med 000:000‐000, 2012. © 2012 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - March 4, 2013 Category: Radiology Authors: Andrew B. Holbrook, Pejman Ghanouni, Juan M. Santos, Charles Dumoulin, Yoav Medan, Kim Butts Pauly Tags: Full paper Source Type: research

Effect of High-Intensity Focused Ultrasound on Enterococcus Faecalis Planktonic Suspensions and Biofilms
This study highlighted the potential application of HIFU as a novel method for root canal disinfection. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - March 1, 2013 Category: Radiology Authors: Kulsum Iqbal, Siew-Wan Ohl, Boo-Cheong Khoo, Jennifer Neo, Amr S. Fawzy Tags: Original Contributions Source Type: research

Noninvasive cardiac arrhythmia therapy using High-Intensity Focused Ultrasound (HIFU) ablation
It is estimated that approximately 7,000,000 people worldwide die from arrhythmias every year. Clinically, as an important strategy for cardiac arrhythmia treatment , over 1,000,000 cases of catheter ablation (to cut some abnormal electrical conduction in the myocardium) are performed globally each year . However, the catheter procedure is associated with certain complications and limitations . Therefore, it is imperative to explore non-invasive, yet safe and efficient, strategies for myocardial ablation. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 1, 2013 Category: Cardiology Authors: Qi Wu, Qi Zhou, Que Zhu, Shunkang Rong, Qi Wang, Rui Guo, Changming Deng, Dichuan Liu, Gang Yang, Yonghong Jiang, ZhiGang Wang, Han Lei, Tong-Chuan He, ZhiBiao Wang, Jing Huang Tags: Online Letters to the editor Source Type: research

Potential Femoral Head Osteonecrosis Model Induced by High-Intensity Focused Ultrasound
Abstract: Osteonecrosis of the femoral head is a common disease that can result in complex hip replacement. To evaluate potential treatments, a model that consistently creates osteonecrosis is needed. We studied and demonstrated the possibility of developing an osteonecrosis model using high-intensity focused ultrasound (HIFU) on canine femora in vitro. To achieve these goals, the temperature in the medullary cavity of the femoral head was measured. A phenomenological model was developed to fit the measured temperature variations with the HIFU parameters for similar HIFU experiments on femoral heads. The average temperatu...
Source: Ultrasound in Medicine and Biology - March 1, 2013 Category: Radiology Authors: T. Long, J. Xu, S.R. McClure, V. Amin, J. Haynes Tags: Original Contributions Source Type: research

Efficacy and Safety of Daily Repeated Sonographically Guided High-Intensity Focused Ultrasound Treatment of Uterine Fibroids: Preliminary Study
Conclusions Although this preliminary report had several limitations, daily repeated HIFU treatment of uterine fibroids may be a useful and safe method and can be used as a different option for HIFU treatment in patients who prefer treatment without anesthesia or sedation. (Source: Journal of Ultrasound in Medicine)
Source: Journal of Ultrasound in Medicine - February 26, 2013 Category: Radiology Authors: Cho, J. Y., Kim, S. H., Kim, S. Y., Moon, S. K., Li, J. Tags: Original Research Source Type: research

USHIFU changes name to SonaCare
High-intensity focused ultrasound (HIFU) developer USHIFU announced it has (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 22, 2013 Category: Radiology Source Type: news

EDAP's Ablatherm-HIFU Offers Reliable Therapy for Localized Prostate Cancer
Munich Study Concludes 15 Year Outcome Data May Warrant Closing of Investigational Phase for HIFU LYON, France, Feb. 22, 2013 -- (Healthcare Sales & Marketing Network) -- EDAP TMS SA (EDAP), the global leader in therapeutic ultrasound, announced today n... Devices, Urology, OncologyEDAP TMS SA, HIFU therapy, Ablatherm, prostate cancer (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 22, 2013 Category: Pharmaceuticals Source Type: news

Safety and Tolerability of a Focused Ultrasound Device for Treatment of Adipose Tissue in Subjects Undergoing Abdominoplasty: A Placebo‐Control Pilot Study
ConclusionsHigh‐intensity focused ultrasound treatment was well tolerated and safe. Focal damage to target tissue was documented, with adjacent tissues remaining intact. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - February 22, 2013 Category: Dermatology Authors: Avshalom Shalom, Itay Wiser, Solli Brawer, Haim Azhari Tags: Original Article Source Type: research

High intensity focused ultrasound: advances in technology and experimental trials support enhanced utility of focused ultrasound surgery in oncology.
PMID: 23403455 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - February 12, 2013 Category: Radiology Authors: Malietzis G, Monzon L, Hand J, Wasan H, Leen E, Abel M, Muhammad A, Price P, Abel P Tags: Br J Radiol Source Type: research

Imaging and Focal Therapy of Early Prostate Cancer
series:Current Clinical UrologyImaging and Focal Therapy of Early Prostate Cancer evaluates the scientific evidence for the evolving trend to treat low to intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and ... (Source: Springer Medicine titles)
Source: Springer Medicine titles - February 11, 2013 Category: Databases & Libraries Tags: Urology / Andrology Source Type: news

EDAP's Ablatherm-HIFU Demonstrates Long-Term Efficacy and Safety Over Fourteen-Year Period
Longest Retrospective Study of HIFU Patients to Date Published Confirms Benefits of Treatment LYON, France, Feb. 8, 2013 -- (Healthcare Sales & Marketing Network) -- EDAP TMS SA (EDAP), the global leader in therapeutic ultrasound, announced today new da... Devices, OncologyEDAP TMS, Ablatherm-HIFU, ultrasound guided HIFU, prostate cancer (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 8, 2013 Category: Pharmaceuticals Source Type: news

Toward permanent pulmonary vein isolation: The use of adenosine to unmask dormant conduction
Atrial fibrillation (AF) remains the most common sustained cardiac arrhythmia and continues to be a major cause of stroke and hospitalizations worldwide. Seminal observations by Haïssaguerre et al in 1998 on the role of pulmonary vein (PV) triggers in AF led to the development of PV isolation as the cornerstone of ablation for AF. However, this initial enthusiasm has been dampened by the high frequency of PV reconnection, resulting in recurrent AF. Therefore, permanent PV isolation remains the “holy grail” for electrophysiologists. The quest for permanent PV isolation has resulted in the development of numerous techno...
Source: Heart Rhythm - February 4, 2013 Category: Cardiology Authors: Kim H. Chan, Raymond W. Sy Tags: Editorial Commentary Source Type: research

[Effect of ablations by pulsed versus continuous high-intensity focused ultrasound on isolated perfused porcine liver].
CONCLUSION: When the target area contains large blood vessels in the pathway of ultrasound ablation, pulsed HIFU can have better therapeutic efficiency to effectively induce tissue damages without affecting the blood vessels. PMID: 23443778 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - February 1, 2013 Category: Universities & Medical Training Authors: Jiao J, Wu F, Zou JZ, Li FQ, Liu F, Zhao X, Wang Q Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

Salvage External Beam Radiotherapy for Recurrent Prostate Adenocarcinoma after High-Intensity Focused Ultrasound as Primary Treatment
Urol Int (DOI:10.1159/000345631) (Source: Urologia Internationalis : Last 20 articles)
Source: Urologia Internationalis : Last 20 articles - January 29, 2013 Category: Urology & Nephrology Source Type: research

Fourteen‐year oncological and functional outcomes of high‐intensity focused ultrasound in localized prostate cancer
Conclusions The study demonstrates the efficacy and safety of HIFU for localized PCa. HIFU is a therapeutic option for patients of advanced age, in the low‐ or intermediate‐risk groups, and with a life expectancy of ∼10 years. (Source: BJU International)
Source: BJU International - January 28, 2013 Category: Urology & Nephrology Authors: Roman Ganzer, Hans‐Martin Fritsche, Andreas Brandtner, Johannes Bründl, Daniel Koch, Wolf F. Wieland, Andreas Blana Tags: Urological Oncology Source Type: research

Histological and Biochemical Analysis of Mechanical and Thermal Bioeffects in Boiling Histotripsy Lesions Induced by High Intensity Focused Ultrasound
Abstract: Recent studies have shown that shockwave heating and millisecond boiling in high-intensity focused ultrasound fields can result in mechanical fractionation or emulsification of tissue, termed boiling histotripsy. Visual observations of the change in color and contents indicated that the degree of thermal damage in the emulsified lesions can be controlled by varying the parameters of the exposure. The goal of this work was to examine thermal and mechanical effects in boiling histotripsy lesions using histologic and biochemical analysis. The lesions were induced in ex vivo bovine heart and liver using a 2-MHz sing...
Source: Ultrasound in Medicine and Biology - January 14, 2013 Category: Radiology Authors: Yak-Nam Wang, Tatiana Khokhlova, Michael Bailey, Joo Ha Hwang, Vera Khokhlova Tags: Original Contributions Source Type: research

It is time to revisit the theory of acute conduction block: efficacy of high-intensity focused ultrasound epicardial ablation [LETTERS TO THE EDITOR]
(Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - January 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Colli, A., Romero-Ferrer, B. Tags: LETTERS TO THE EDITOR Source Type: research

A Tissue Mimicking Polyacrylamide Hydrogel Phantom for Visualizing Thermal Lesions Generated by High Intensity Focused Ultrasound
In conclusion, the proposed TM BSA-PAG acoustically mimics tissue better than the standard BSA-PAG and is expected to be preferentially used for assuring if a clinical HIFU device produces the thermal lesion as planned. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 10, 2013 Category: Radiology Authors: Min Joo Choi, Sitaramanjaneya Reddy Guntur, Kang IL Lee, Dong Guk Paeng, Andrew Coleman Tags: Original Contributions Source Type: research

Au-nanoparticle coated mesoporous silica nanocapsule-based multifunctional platform for ultrasound mediated imaging, cytoclasis and tumor ablation.
Abstract Au nanoparticles-coated, perfluorohexane-encapsulated and PEGylated mesoporous silica nanocapsule-based enhancement agents (MSNC@Au-PFH-PEG, abb. as MAPP) have been synthesized, for the ultrasound-induced cytoclasis, contrast-intensified ultrasound (US) imaging and US-guided high intensity focused ultrasound (HIFU) surgical therapy. Both the US-induced thermal effect and US triggered release of loaded model drug with MAPP under US exposure indicated the excellent US sensitivity of MAPP and its applicability for the combined chemo-/thermal therapy and future potential for HIFU ablation; US imaging under dif...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Wang X, Chen H, Zheng Y, Ma M, Chen Y, Zhang K, Zeng D, Shi J Tags: Biomaterials Source Type: research

[Accuracy of correlation function method for evaluating pulsed high intensity focused ultrasound].
CONCLUSION: Monitoring of tissue necrosis caused by PHIFU treatment can not rely solely on evaluation of gray-scale change of the ultrasound images, and the correlation function-based evaluation can be more accurate and sensitive for that purpose. PMID: 23353153 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - January 1, 2013 Category: Universities & Medical Training Authors: Zhao X, Zou JZ, Wu F, Liu F, Jiao J Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

Assessment of Ultrasound Histotripsy-Induced Damage to Ex Vivo Porcine Muscle
Conclusions— Using a finer scan step size promoted the lesion homogeneity. Selection of the optimal condition does not depend solely on the comparison of tissue damage. Given the uncertainty on which of the 3 scales for tissue damage allows muscle repair, 2 conditions were identified as optimal: the 1500 μm-333 Hz condition for scale 3 (related to mild damage) and the 750 μm-333 Hz condition for scale 1 (related to severe damage). (Source: Journal of Ultrasound in Medicine)
Source: Journal of Ultrasound in Medicine - December 26, 2012 Category: Radiology Authors: Xu, J., Bigelow, T. A., Whitley, E. M. Tags: Original Research Source Type: research

The optimization of acoustic fields for ablative therapies of tumours in the upper abdomen.
Abstract High intensity focused ultrasound (HIFU) enables highly localized, non-invasive tissue ablation and its efficacy has been demonstrated in the treatment of a range of cancers, including those of the kidney, prostate and breast. HIFU offers the ability to treat deep-seated tumours locally, and potentially bears fewer side effects than more invasive treatment modalities such as resection, chemotherapy and ionizing radiation. There remains however a number of significant challenges which currently hinder its widespread clinical application. One of these challenges is the need to transmit sufficient energy thro...
Source: Physics in Medicine and Biology - December 21, 2012 Category: Physics Authors: Gélat P, Ter Haar G, Saffari N Tags: Phys Med Biol Source Type: research

MRI contrast variation of thermosensitive magnetoliposomes triggered by focused ultrasound: a tool for image‐guided local drug delivery
In conclusion, HIFU under MR image guidance in combination with USPIO‐loaded thermosensitive liposomes as drug delivery system has the potential for a better control of drug delivery and to increase the drug therapeutic index. Copyright © 2012 John Wiley & Sons, Ltd. Thermosensitive liposomes are attractive carriers for local chemotherapy since release of their contents can be triggered non‐invasively by an external heat source. Labeling with iron oxide nanoparticles makes these liposomes visible on MRI and, moreover, provides a detection system for liposome membrane permeabilization. Results showed significant di...
Source: Contrast Media and Molecular Imaging - December 20, 2012 Category: Radiology Authors: Cyril Lorenzato, Alexandru Cernicanu, Marie‐Edith Meyre, Matthieu Germain, Agnès Pottier, Laurent Levy, Baudouin Denis Senneville, Clemens Bos, Chrit Moonen, Pierre Smirnov Tags: Full Paper Source Type: research

Characterizing an Agar/Gelatin Phantom for Image Guided Dosing and Feedback Control of High-Intensity Focused Ultrasound
Abstract: The temperature dependence of an agar/gelatin phantom was evaluated. The purpose was to predict the material property response to high-intensity focused ultrasound (HIFU) for developing ultrasound guided dosing and targeting feedback. Changes in attenuation, sound speed, shear modulus and thermal properties with temperature were examined from 20°C to 70°C for 3 weeks post-manufacture. The attenuation decreased with temperature by a power factor of 0.15. Thermal conductivity, diffusivity and specific heat all increased linearly with temperature for a total change of approximately 16%, 10% and 6%, respectively. S...
Source: Ultrasound in Medicine and Biology - December 17, 2012 Category: Radiology Authors: Barbrina Dunmire, John C. Kucewicz, Stuart B. Mitchell, Lawrence A. Crum, K. Michael Sekins Tags: Original Contributions Source Type: research

Pulsed High-Intensity Focused Ultrasound Therapy Enhances Targeted Delivery of Cetuximab to Colon Cancer Xenograft Model in Mice
In conclusion, pulsed HIFU therapy appears to enhance the anti-tumor effect of epidermal growth factor receptor–targeted cetuximab on human colon cancer xenograft models in mice. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - December 5, 2012 Category: Radiology Authors: Min Jung Park, Young-sun Kim, Jehoon Yang, Woo Chul Sun, Hajan Park, Sun Young Chae, Mi-Sun Namgung, Kyu-Sil Choi Tags: Original Contributions Source Type: research

Survival analysis of high‐intensity focused ultrasound ablation in patients with small hepatocellular carcinoma
ConclusionsHIFU ablation is a safe and effective method for small HCCs. It can achieve survival outcomes comparable to those of percutaneous RFA and thus serves as a good alternative ablation treatment for patients with cirrhosis. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - December 4, 2012 Category: Gastroenterology Authors: Tan To Cheung, Sheung Tat Fan, Ferdinand S. K. Chu, Caroline R. Jenkins, Kenneth S. H. Chok, Simon H. Y. Tsang, Wing Chiu Dai, Albert C. Y. Chan, See Ching Chan, Thomas C. C. Yau, Ronnie T. P. Poon, Chung Mau Lo Tags: Original Article Source Type: research

Ultrasonic atomization of tissue and its role in tissue fractionation by high intensity focused ultrasound.
We describe an experiment, in which a 2 MHz HIFU transducer (maximum in situ intensity of 24 000 W cm(-2)) was aligned with an air-tissue interface meant to simulate the boiling bubble. Atomization and fountain formation was observed with high-speed photography and resulted in tissue erosion. Histological examination of the atomized tissue showed whole and fragmented cells and nuclei. Air-liquid interfaces were also filmed. Our conclusion was that HIFU can fountain and atomize tissue. Although this process does not entirely mimic what was observed in liquids, it does explain many aspects of tissue fractionation in boi...
Source: Physics in Medicine and Biology - November 21, 2012 Category: Physics Authors: Simon JC, Sapozhnikov OA, Khokhlova VA, Wang YN, Crum LA, Bailey MR Tags: Phys Med Biol Source Type: research

Low-pressure pulsed focused ultrasound with microbubbles promotes an anticancer immunological response
Conclusions: Our findings suggest that low-pressure FUS exposure with MBs may constitute a useful tool for triggering an anticancer immune response, for potential cancer immunotherapy. (Source: BioMed Central)
Source: BioMed Central - November 11, 2012 Category: Journals (General) Authors: Hao-Li LiuHan-Yi HsiehLi-An LuChiao-Wen KangMing-Fang WuChun-Yen Lin Source Type: research

[Establishment of an isolated porcine liver machine perfusion model for high-intensity focused ultrasound studies].
CONCLUSION: The isolated porcine liver perfusion model is stable and feasible, and can be used for high-intensity focused ultrasound studies. PMID: 23174575 [PubMed - in process] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 1, 2012 Category: Universities & Medical Training Authors: Bu R, Zou JZ, Yin L, Wu F, Meng SH, Liu F, Zhao X, Jiao J, Yang H Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

High‐intensity focused ultrasound combined with herpes simplex virus thymidine kinase gene‐loaded ultrasound‐targeted microbubbles improved the survival of rabbits with VX2 liver tumor
ConclusionsHIFU combined with HSV‐TK gene‐loaded ultrasound‐targeted MBs significantly inhibited the growth of VX2 rabbit liver tumors in vivo and prolonged the survival time of the animals, providing a novel gene delivery method and a novel strategy for liver tumor treatment. Copyright © 2012 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 29, 2012 Category: Genetics & Stem Cells Authors: Shi‐Ji Zhou, Sheng‐Wei Li, Ji‐Jian Wang, Zuo‐Jin Liu, Guo‐Bing Yin, Jian‐Ping Gong, Chang‐An Liu Tags: Research Article Source Type: research

3D Multi-parametric Breast MRI Segmentation Using Hierarchical Support Vector Machine with Coil Sensitivity Correction
Conclusion: The presented hierarchical SVM-based technique showed promising results in automatically segmenting breast tissues into fat, fibroglandular tissue, skin, and lesions. The results provide evidence that both the multiparametric breast MRI inputs and the preprocessing procedures contribute to the high accuracy of tissue classification. (Source: Academic Radiology)
Source: Academic Radiology - October 24, 2012 Category: Radiology Authors: Yi Wang, Glen Morrell, Marta E. Heibrun, Allison Payne, Dennis L. Parker Tags: Original Investigations Source Type: research

MR Thermometry Analysis of Sonication Accuracy and Safety Margin of Volumetric MR Imaging-guided High-Intensity Focused Ultrasound Ablation of Symptomatic Uterine Fibroids [Vascular and Interventional Radiology]
Conclusion: Sonication accuracy of volumetric MR imaging–guided high-intensity focused ultrasound ablation of uterine fibroids appears clinically acceptable and may be further improved by feedback control to produce more consistent ablation zones. © RSNA, 2012 (Source: Radiology)
Source: Radiology - October 23, 2012 Category: Radiology Authors: Kim, Y.-s., Trillaud, H., Rhim, H., Lim, H. K., Mali, W., Voogt, M., Barkhausen, J., Eckey, T., Kohler, M. O., Keserci, B., Mougenot, C., Sokka, S. D., Soini, J., Nieminen, H. J. Tags: Interventional Radiology, Genitourinary Radiology Vascular and Interventional Radiology Source Type: research

Volumetric MR-guided high-intensity focused ultrasound ablation of uterine fibroids: treatment speed and factors influencing speed
Conclusion Volumetric MR-HIFU ablation can effectively treat symptomatic uterine fibroids. The treatment speed appeared to improve when treating large and/or dark fibroids as well as upon completion of the learning curve. Key Points • High-intensity focused ultrasound (HIFU) offers another interventional radiological option for treating fibroids • Volumetric MR-guided HIFU ablation can treat uterine fibroids in a timely fashion • Treatment speed appeared to improve when treating large and/or dark fibroids • Treatment speed appeared to improve upon complet...
Source: European Radiology - October 19, 2012 Category: Radiology Tags: European Radiology Source Type: research

TCT-768 Noninvasive cardiac arrhythmia therapy using High-Intensity Focused Ultrasound (HIFU) ablation
(Source: Journal of the American College of Cardiology: Cardiovascular Imaging)
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - October 16, 2012 Category: Radiology Source Type: research