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Replication and drug resistant mutation of HIV-1 subtype B' (Thailand B) variants isolated from HAART treatment individuals in ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggested that the drug resistant level could not reduce in vitro in absence of antiretroviral drugs in few weeks. And maybe helpful for these HAART experienced individuals when change antiretroviral drugs. (Source: Virology Journal)
Source: Virology Journal - November 18, 2009 Category: Virology Authors: Jianping SunLiying MaXiaoling YuYang HuangLin YuanYiming Shao Source Type: journals

Standard care quality determines treatment outcomes in control groups of HAART-adherence intervention studies: Implications for the interpretation and comparison of intervention effects.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Variation in SCQ provided to control groups may substantially influence effect sizes of behavior change interventions. Future trials should therefore assess and report SCQ, and meta-analyses should control for variability in SCQ, thereby producing more accurate estimates of the effectiveness of behavior change interventions. (PsycINFO Database Record (c) 2009 APA, all rights reserved) (Source: Health Psychology)
Source: Health Psychology - November 17, 2009 Category: Psychiatry & Psychology Authors: de Bruin, Marijn; Viechtbauer, Wolfgang; Hospers, Harm J.; Schaalma, Herman P.; Kok, Gerjo Source Type: journals

[Reflection and Reaction] Relative risk of death in the SMART studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the May issue of The Lancet Infectious Diseases, Justin Stebbing and Angus Dalgleish noted that 79 of the 85 deaths (93%) in the SMART study happened in the USA, whereas 45% of the participants were enrolled outside the USA. They concluded that it was “apparently safer to be off highly active antiretroviral therapy (HAART) outside the USA rather than on HAART within the USA”, and contemplated possible reasons for this difference. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - November 16, 2009 Category: Infectious Diseases Authors: Birgit Grund, Jacqueline Neuhaus, Andrew Phillips, for the INSIGHT SMART Study Group Tags: Reflection and Reaction Source Type: journals

Newer trends in the management of genital herpesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nath Amiya Kumar, Thappa Devinder MohanIndian Journal of Dermatology, Venereology, and Leprology 2009 75(6):566-574Management of genital herpes is complex. Apart from using the standard antivirals, an ideal management protocol also needs to address various aspects of the disease, including the psychological morbidity. Oral acyclovir, valacyclovir or famciclovir are recommended for routine use. Long-term suppressive therapy is effective in reducing the number of recurrences and the risk of transmission to others. Severe or disseminated disease may require intravenous therapy. Resistant cases are managed with foscarnet or ci...
Source: Indian Journal of Dermatology, Venereology and Leprology - November 12, 2009 Category: Dermatology Authors: Nath Amiya Kumar, Thappa Devinder Mohan Source Type: journals

Lipodystrophy and metabolic complications of highly active antiretroviral therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Metabolic abnormalities and lipodystrophy are emerging complications of HAART in Indian children and needs very close follow up. Future studies with larger sample size and longitudinal model are recommended. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12098-009-0216-9Authors Ankit Parakh, Maulana Azad Medical College and Associated Hospitals Department of Pediatrics New Delhi IndiaAnand Prakash Dubey, Maulana Azad Medical College and Associated Hospitals Department of Pediatrics New Delhi IndiaAjay Kumar, Maulana Azad Medical College and Associated Hospitals Department ...
Source: Indian Journal of Pediatrics - November 11, 2009 Category: Pediatrics Tags: Indian Journal of Pediatrics Source Type: journals

Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This suggests that the use of integrase inhibitors against HIV-1 subtype C will result in comparable outcomes to those obtained against subtype B infections. (Source: Retrovirology)
Source: Retrovirology - November 11, 2009 Category: Virology Authors: Tamara Bar-MagenRichard SloanVerena FaltenbacherD. Aaron DonahueBjorn KuhlMaureen OliveiraHongtao XuMark Wainberg Source Type: journals

HIV-associated parkinsonism with levodopa-induced dyskinesia and response to highly-active antiretroviral therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Movement Disorders)
Source: Movement Disorders - November 11, 2009 Category: Neurology Authors: Christopher Kobylecki, Monty A. Silverdale, Anoop Varma, Jeremy P.R. Dick, Mark W. Kellett Source Type: journals

[Severe aseptic leucoencephalopathy : Manifested as immune reconstitution inflammatory syndrome in Caucasian and African patients.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Starting HAART, HIV-1-positive patients may develop an aseptic type of IRIS of the CNS without any detectable opportunistic infection, a finding that has not yet been published. This makes them susceptible for successful treatment with corticosteroids. Perhaps IRIS has a higher incidence in African patients and the patients have a poorer outcome than Caucasians. PMID: 19902166 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 11, 2009 Category: Neurology Authors: Ringelstein A, Oelschlaeger C, Arendt G, Mathys C, Dziewas R, Niederstadt T, Reichelt D, Hasselblatt M, Husstedt IW, Saleh A Tags: Nervenarzt Source Type: journals

Non-polymeric nano-carriers in HIV/AIDS drug delivery and targeting.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Development of an effective drug delivery approach for the treatment of HIV/AIDS is a global challenge. The conventional drug delivery approaches including Highly Active Anti Retroviral Therapy (HAART) have increased the life span of the HIV/AIDS patient. However, the eradication of HIV is still not possible with these approaches due to some limitations. Emergence of polymeric and non-polymeric nanotechnological approaches can be opportunistic in this direction. Polymeric carriers like, dendrimers and nanoparticles have been reported for the targeting of anti HIV drugs. The synthetic pathways as well polymeric framewor...
Source: Advanced Drug Delivery Reviews - November 11, 2009 Category: Drugs & Pharmacology Authors: Gupta U, Jain NK Tags: Adv Drug Deliv Rev Source Type: journals

Can Microbicides Turn the Tide against HIV?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The global impact of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is increasing and traditional preventative 'safe sex' strategies do not seem to be slowing the spread of this virus. With an efficacious vaccine at least a decade away, the only strategy to avoid the ever-increasing cost of highly active antiretroviral therapy (HAART) is to develop new methods that prevent virus transmission. Microbicides are topically-applied molecules that disrupt the HIV cycle and block infection. This review discusses the current state of the art in microbicide development, looking at the most clinically...
Source: Current Pharmaceutical Design - November 10, 2009 Category: Drugs & Pharmacology Authors: Ramessar K, Sabalza M, Miralpeix B, Capell T, Christou P Tags: Curr Pharm Des Source Type: journals

Impact of Highly Active Antiretroviral Therapy (HAART) on AIDS and Death in a Cohort of Vertically HIV Type 1-Infected Children: 1980–2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Source: AIDS Research and Human Retroviruses - November 6, 2009 Category: Infectious Diseases Tags: article Source Type: journals

HIV: treating tuberculosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New evidence; conclusion confirmed for: Early initiation of highly active antiretroviral treatment Two cohort studies added. One prospective study found mortality was increased the longer HAART initiation was delayed after starting antituberculosis treatment, and found decreased mortality in people with bacteriologically confirmed tuberculosis, who started HAART within the first 120 days of antituberculosis treatment versus people who started HAART later than this. Another study (retrospective from 1996 to 2000; prospective from 2000 to 2004) found better survival in people who started H...
Source: Clinical Evidence - November 5, 2009 Category: Journals (General) Source Type: journals

The Role of Body Image Dissatisfaction and Depression on HAART Adherence in HIV Positive Men: Tests of Mediation ModelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The current study examined the role of body image dissatisfaction and depression on HAART adherence in a sample of HIV positive men. Participants were 124 HIV positive gay and bisexual men, who responded to an online survey. Results from moderated mediation models revealed that depression mediated the relationship between body dissatisfaction and HAART non-adherence for men who possessed elevated levels of body dissatisfaction, but not for those men who reported moderate or low levels. Additionally, depression was found to mediate the relationship between body dissatisfaction and HAART non-adherence...
Source: AIDS and Behavior - November 4, 2009 Category: Infectious Diseases Tags: AIDS and Behavior Source Type: journals

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe here the development of what we believe to be a novel in vitro model of HIV-1 latency that we used to search for compounds that can reverse latency. Human primary CD4+ T cells were transduced with the prosurvival molecule Bcl-2, and the resulting cells were shown to recapitulate the quiescent state of resting CD4+ T cells in vivo. Using this model system, we screened small-molecule libraries and identified a compound that reactivated latent HIV-1 without inducing global T cell activation, 5-hydroxynaphthalene-1,4-dione (5HN). Unlike previously described latency-reversing agents, 5HN activated latent HIV-1 throu...
Source: Journal of Clinical Investigation - November 3, 2009 Category: Biomedical Science Authors: Hung-Chih Yang, Sifei Xing, Liang Shan, Karen O’Connell, Jason Dinoso, Anding Shen, Yan Zhou, Cynthia K. Shrum, Yefei Han, Jun O. Liu, Hao Zhang, Joseph B. Margolick, Robert F. Siliciano Source Type: journals

Discussion and revision of the mathematical modeling tool described in the previously published article Modeling HIV Transmission risk among Mozambicans prior to their initiating highly active antiretroviral therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: AIDS Care)
Source: AIDS Care - November 1, 2009 Category: Infectious Diseases Authors: Cassels, SusanPearson, CynthiaKurth, AnnMartin, DianeSimoni, JaneMatediana, EduardoGloyd, Stephen Source Type: journals

Access to highly active antiretroviral therapy (HAART) for women and children in the WHO European Region 2002-2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: AIDS Care)
Source: AIDS Care - November 1, 2009 Category: Infectious Diseases Authors: Stengaard, Annemarie RinderLazarus, JeffreyDonoghoe, MartinNielsen, StineMatic, Srdan Source Type: journals

Human immunodeficiency virus-associated lung carcinoma presenting as cutaneous metastases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present 2 cases of lung carcinoma that manifested initially with cutaneous metastases. Both patients were men (37 and 43 years old) with known AIDS that presented with multiple skin nodules mainly on the trunk (back and shoulder). These cases demonstrate that cutaneous metastases might represent the first sign of an internal HIV-related malignancy. Recognition of skin metastases is important for prompt diagnosis and initiation of proper therapy. With the growing problem of non-AIDS-defining cancers in the current era of HAART, clinicians should be aware that skin lesions in the HIV-infected individual might represent me...
Source: Clinical Lung Cancer - November 1, 2009 Category: Cancer & Oncology Authors: Hamdan A, Dezube BJ, Pantanowitz L Tags: Clin Lung Cancer Source Type: journals

Antiretroviral and Immunosuppressive Drug-Drug Interactions in Human Immunodeficiency Virus–Infected Liver and Kidney Transplant RecipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Highly active antiretroviral therapy (HAART) has significantly reduced mortality, and prolonged life expectancy of human immunodeficiency virus (HIV)-positive patients. Such improvements have led to increasing numbers of HIV-infected patients with end-stage organ disease as potential candidates for transplantation. A HAART regimen usually consists of a combination of nucleoside reverse transcriptase inhibitors (NRTI), non-nucleoside reverse transcriptase inhibitors (NNRTI), and/or protease inhibitors (PI). PI are known to strongly inhibit the cytochrome P450 3A (CYP3A) enzyme system that is responsible for the me...
Source: Transplantation Proceedings - November 1, 2009 Category: Transplant Surgery Authors: K. Marfo, S. Greenstein Tags: Liver Transplantation Source Type: journals

Discordance in HIV-1 Viral Loads and Antiretroviral Drug Concentrations Comparing Semen and Blood PlasmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When a male patient has undetectable plasma viral loads thanks to HAART, is he sexually noninfectious? Maybe not, if the drugs aren't penetrating to his genital tract. HIV Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 27, 2009 Category: Consumer Health News Tags: HIV/AIDS Source Type: news

T Cell Dynamics and the Response to HAART in a Cohort of HIV‐1–Infected Elite SuppressorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10‐year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - October 27, 2009 Category: Infectious Diseases Tags: article HIV/AIDS Source Type: journals

Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is generally accepted that oxidative stress is involved in HIV infection. However, the role in oxidative balance of Highly Active Antiretroviral Therapy (HAART) is still debated. In our study we assessed serum oxidant and antioxidant levels in an HIV-1-infected population treated with HAART, and compared them with those of untreated HIV-1 patients and HIV-1-negative subjects. The study included 116 HIV-1-infected patients (86 HAART-treated and 30 untreated), and 46 HIV-negative controls. Serum oxidant levels were significantly higher in the HIV-1 treated group as compared to untreated and control groups. In addition, a ...
Source: Journal of Biomedicine and Biotechnology - October 26, 2009 Category: Biotechnology Source Type: journals

Lack of Effect on Prematurity, Birth Weight, and Infant Growth from Exposure to Protease Inhibitors In Utero and After BirthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Significantly higher rates of prematurity and low birth weight were not demonstrated in infants exposed in utero to HAART with protease inhibitors. Moreover, these children reached normal growth percentiles during the first 2 years of life. (Source: Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy)
Source: Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy - October 26, 2009 Category: Drugs & Pharmacology Authors: Ana CarcellerEma FerreiraSophie AlloulNormand Lapointe Source Type: journals

HIV: No place to hideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Reviews Microbiology 7, 840 (2009). doi:10.1038/nrmicro2263 Author: Andrew Jermy Although highly active antiretroviral therapy (HAART) can reduce viral load below detectable levels, it cannot cure HIV-1 infection, owing to the presence of a reservoir of latent integrated HIV-1 proviruses in resting CD4+ T cells. Coupling the reactivation of this viral reservoir with (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - October 26, 2009 Category: Microbiology Authors: Andrew Jermy Tags: Research Highlight Source Type: journals

Prevalence of human papillomaviruses in urine samples of male patients infected with HIV-1 in Sao Paulo, BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study included 223 patients infected with HIV-1 from the Center of Reference on HIV/AIDS (CRT-SP) and an outpatient clinic of HIV. Urine samples were collected and after DNA extraction real-time PCR was performed for detection of HPV DNA. Positive samples were then tested by conventional PCR using type-specific primers for the four HPV types. A total of 223 men infected with HIV-1 were tested, 81% of whom were on HAART. Four (5.8%) were positive for HPV6, 18 (26.1%) were positive for HPV11, 22 (31.9%) were positive for HPV16 and five (7.2%) were positive for HPV18 by conventional PCR. Twenty (29%) patients had other H...
Source: Journal of Medical Virology - October 25, 2009 Category: Virology Authors: Fernando A.M. Costa, Roberto Carvalho da Silva, Liã B. Arruda, Alberto J.S. Duarte, Jorge Casseb Tags: Research Article Source Type: journals

Co-receptor switch during HAART is independent of virological successEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The influence of antiretroviral therapy on co-receptor tropism remains controversial. To verify if co-receptor tropism shift was affected by HAART, the evolution of proviral DNA V3 genotype after 12 months of a new antiretroviral regimen was compared between responder and non-responder patients. Baseline blood samples were collected from 36 patients infected with HIV-1 subtype-B (18 naïve and 18 experienced) for virus isolation and env V3 genotyping from plasma HIV-1 RNA and PBMC DNA. DNA V3 genotyping was repeated after 12 months from initiating HAART. WebPSSM was used for categorizing V3 sequences into X4 or R5; for ana...
Source: Journal of Medical Virology - October 25, 2009 Category: Virology Authors: Annalisa Saracino, Laura Monno, Donatella C. Cibelli, Grazia Punzi, Gaetano Brindicci, Nicoletta Ladisa, Alessandra Tartaglia, Antonella Lagioia, Gioacchino Angarano Tags: Research Article Source Type: journals

An AIDS patient with immune reconstitution inflammatory syndrome due to pulmonary Mycobacterium kansasii infection during antiretroviral therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract After the recovery of pneumocystis pneumonia, amebiasis, and cytomegalovirus duodenal ulcer in a patient with AIDS, antiretroviral therapy was initiated. Fever was first noted on the 11th day of administration of the highly active antiretroviral therapy (HAART), and chest radiography showed infiltration into the right lower lobe of the lung on the 19th day. Bronchoscopy was performed, with a tentative diagnosis of pulmonary tuberculosis, but Mycobacterium kansasii was eventually identified. M. kansasii may also be a pathogenic organism causing immune reconstitution inflammatory syndrome. Content T...
Source: Journal of Infection and Chemotherapy - October 24, 2009 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: journals

Early Mortality and Cause of Deaths in Patients Using HAART in Brazil and the United StatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
What HIV-infected patients die from, and when they die, is different in Baltimore than in Rio de Janeiro -- but one aspect of care is unfortunately the same in both cities. AIDS (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - October 23, 2009 Category: Infectious Diseases Tags: HIV/AIDS Source Type: info

Taking Medicine For HIV Proves Hard To Swallow For Many PeopleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Highly active antiretroviral therapy has increased the longevity and quality of life for people living with human immunodeficiency virus. But it requires strict adherence in taking the medicine, something that is extremely difficult for many individuals to do. Two new University of Washington studies illustrate just how hard it is to make sure people take their HIV medication. (Source: HIV / AIDS News From Medical News Today)
Source: HIV / AIDS News From Medical News Today - October 23, 2009 Category: Infectious Diseases Tags: HIV / AIDS Source Type: news

Understanding and Managing the Adverse Effects of Antiretroviral Therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article forms part of a special issue of Antiviral Research marking the 25th anniversary of antiretroviral drug discovery and development, Vol 85, issue 1, 2010. PMID: 19857521 [PubMed - as supplied by publisher] (Source: Antiviral Research)
Source: Antiviral Research - October 23, 2009 Category: Virology Authors: Hawkins T Tags: Antiviral Res Source Type: journals

Immune reconstitution inflammatory syndrome involving the skinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. New skin lesions were very common in this cohort, with the majority being women and patients with very low baseline CD4 counts. (Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: B. Osei-Sekyere, A. S. Karstaedt Source Type: journals

2.4 HIV Protease inhibitors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HIV protease plays a crucial role in the viral life cycle and is essential for the generation of mature infectious virus particles. Detailed knowledge of the structure of HIV protease and its substrate has led to the design of specific HIV protease inhibitors. Unfortunately, resistance to all protease inhibitors (PI) has been observed and the genetic basis of resistance has been well documented over the past 15 years. The arrival of the early PIs was a pivotal moment in the development of antiretroviral therapy. They made possible the dual class triple combination therapy that became known as HAART. However, the clinic...
Source: Antiviral Research - October 21, 2009 Category: Virology Authors: Wensing AM, van Maarseveen NM, Nijhuis M Tags: Antiviral Res Source Type: journals

HLA-Cw*04 allele associated with nevirapine-induced rash in HIV-infected Thai patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study suggests that HLA-Cw*04 is associated with rash in nevirapine treated Thais. Future screening of patients' HLA may reduce the number of nevirapine-induced rash cases, and patients with alleles associated with nevirapine-induced rash should be started on anti-retroviral therapy without nevirapine. (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 20, 2009 Category: Infectious Diseases Authors: Sirirat LikanonsakulTippawan RattanathamSiriluk FeangvadSumonmal UttayamakulWisit PrasithsirikulPreecha TunthanathipEmi NakayamaTatsuo Shioda Source Type: journals

HLA-Cw*04 allele associated with nevirapine-induced rash in HIV-infected Thai patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This study suggests that HLA-Cw*04 is associated with rash in nevirapine treated Thais. Future screening of patients' HLA may reduce the number of nevirapine-induced rash cases, and patients with alleles associated with nevirapine-induced rash should be started on anti-retroviral therapy without nevirapine. PMID: 19845952 [PubMed - as supplied by publisher] (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - October 20, 2009 Category: Infectious Diseases Authors: Likanonsakul S, Rattanatham T, Feangvad S, Uttayamakul S, Prasithsirikul W, Tunthanathip P, Nakayama EE, Shioda T Tags: AIDS Res Ther Source Type: journals

Meta‐Analysis: Increased Mortality Associated with Hepatitis C in HIV‐Infected Persons Is Unrelated to HIV Disease ProgressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. HCV coinfection did not increase mortality among patients with HIV infection before the introduction of HAART. In contrast, in the HAART era, HCV coinfection, compared with HIV infection alone, increases the risk of mortality, but not the risk of AIDS‐defining events. Future studies should determine whether successful treatment of HCV infection could reduce this excess risk of mortality in coinfected patients. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - October 20, 2009 Category: Infectious Diseases Tags: article HIV/AIDS Source Type: journals

Vascular risk factors, HIV serostatus, and cognitive dysfunction in gay and bisexual menEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings suggest that HIV infection may not be the most important predictor of cognitive performance among older gay and bisexual men in the post–highly active antiretroviral therapy era, at least among those with access to medical care and to appropriate medications. Medical factors associated with normal aging are significantly associated with performance on neuropsychological tests, and good clinical management of these factors both in HIV-infected individuals and those at risk for infection may have beneficial effects in the short term and could reduce the risk of subsequent cognitive decline. (Source: Neurology)
Source: Neurology - October 19, 2009 Category: Neurology Authors: Becker, J. T., Kingsley, L., Mullen, J., Cohen, B., Martin, E., Miller, E. N., Ragin, A., Sacktor, N., Selnes, O. A., Visscher, B. R., For the Multicenter AIDS Cohort Study Tags: HIV, Cardiac; see Cerebrovascular Disease/Cardiac, HIV dementia ARTICLES Source Type: journals

Maternal HIV-1 Treatment Protects Against Transmission To NewbornsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mothers receiving highly active antiretroviral therapy (HAART) to treat HIV-1 infection are less likely than untreated mothers to transmit the virus to their newborns through breastfeeding, according to a new study. The findings, now available online in the Nov. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 19, 2009 Category: Consumer Health News Tags: HIV / AIDS Source Type: news

Maternal HIV-1 Treatment Protects Against Transmission To NewbornsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mothers receiving highly active antiretroviral therapy to treat HIV-1 infection are less likely than untreated mothers to transmit the virus to their newborns through breastfeeding, according to a new study. The findings suggest HAART regimens should be initiated as early as possible in eligible mothers in areas with limited resources, such as Africa, where most infant HIV-1 infections occur, and breastfeeding is common. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 19, 2009 Category: Science Source Type: news

Immune control of HIV-1 infection after therapy interruption: immediate versus deferred antiretroviral therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our conclusion is that, since there is no therapy to date that guarantees life-long protection, deferral of therapy should be preferred in order to minimize the risk of adverse effects, the occurrence of drug resistances and the costs of treatment. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - October 19, 2009 Category: Infectious Diseases Authors: Paola PaciRossella CarelloMassimo BernaschiGianpiero D'OffiziFilippo Castiglione Source Type: journals

[Errata] ErratumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bartlett JA, Shao JF. Success, challenges, and limitations of current antiretroviral therapy in low-income and middle-income countries. Lancet Infect Dis 2009; 9: 637–49. Page 640, reference 31 should cite Zhou J, Li PC, Kumarasamy N, Boyd MA, Pujari S, on behalf of The TREAT Asia HIV Observational Database. Deferred modification of antiretroviral regimen following treatment failure in Asia: results from the TREAT Asia HIV Observational Database (TAHOD). 17th International AIDS Conference; Mexico City, Mexico; Aug 3–8, 2008. Abstract TUPE0116. Page 641, reference 84 should cite Losina E, Chang Y, Campbell E, Walensky R...
Source: The Lancet Infectious Diseases - October 18, 2009 Category: Infectious Diseases Authors: The Lancet Infectious Diseases Tags: Errata Source Type: journals

Immune control of HIV-1 infection after therapy interruption: immediate versus deferred antiretroviral therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our conclusion is that, since there is no therapy to date that guarantees life-long protection, deferral of therapy should be preferred in order to minimize the risk of adverse effects, the occurrence of drug resistances and the costs of treatment. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - October 18, 2009 Category: Infectious Diseases Authors: Paola PaciRossella CarelloMassimo BernaschiGianpiero D'OffiziFilippo Castiglione Source Type: journals

Lipid profile, cardiovascular risk factors and metabolic syndrome in a group of AIDS patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although the mean values for total cholesterol, HDL-c and triglycerides were higher in the HAART group, a higher cardiovascular risk was not identified in the former. The prevalence of metabolic syndrome was comparable in both groups.FUNDAMENTO: Desde el surgimiento del SIDA, la terapia antiretroviral se desarrolló significantemente. Al incluir la terapia antiretroviral altamente activa (HAART), la enfermedad adquirió una característica crónica. Sin embargo, tras la introducción de HAART, diversas alteraciones metabólicas se observaron, principalmente relacionadas al perfil lipídico. OBJETIVO: Evaluar y...
Source: Arquivos Brasileiros de Cardiologia - October 16, 2009 Category: Cardiology Source Type: journals

Breast Enlargement in HIV and AIDSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: True gynaecomastia in HIV AIDS can result from HIV infection, from the HAART regime and from hepatic impairment or hepatic failure leading to hormonal imbalance. Pseudogynaecomastia may be a consequence of lipodystrophy syndrome. We evaluated the reported incidence of gynaecomastia related to HIV/AIDS in England and frequency of surgical intervention. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Norlia Abdullah, S. Edwards, M. Douek Tags: Abstracts Source Type: journals

Maternal HIV-1 treatment protects against transmission to newbornsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Infectious Diseases Society of America) Mothers receiving highly active antiretroviral therapy to treat HIV-1 infection are less likely than untreated mothers to transmit the virus to their newborns through breastfeeding, according to a new study. The findings, now available online in the November 15 issue of the Journal of Infectious Diseases, suggest HAART regimens should be initiated as early as possible in eligible mothers in areas with limited resources, such as Africa, where most infant HIV-1 infections occur, and breastfeeding is common. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 16, 2009 Category: Global & Universal Source Type: news

Postnatal HIV‐1 Transmission after Cessation of Infant Extended Antiretroviral Prophylaxis and Effect of Maternal Highly Active Antiretroviral TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. Background. The association between postnatal human immunodeficiency virus type 1 (HIV‐1) transmission and maternal highly active antiretroviral therapy (HAART) after infant extended antiretroviral prophylaxis was assessed. Methods. A follow‐up study was conducted for the Post‐Exposure Prophylaxis of Infants trial in Blantyre, Malawi (PEPI‐Malawi). In PEPI‐Malawi, breast‐feeding infants of HIV‐infected women were randomized at birth to receive a either control regimen (single‐dose nevirapine plus 1 week of zidovudi...
Source: The Journal of Infectious Diseases Latest Issue - October 15, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

Effective Treatment of Patients in a Deep Salvage Situation with “Non-Active HAART”: Experiences with the Expert Advice System RADATAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Despite extensive pre-treatment and multiple resistances against prescribed HAART, our patients demonstrated a decline in viral load and a stable CD4-cell count over the observation period. We conclude that the activity of antiretroviral regimens is not exclusively explained by the current algorithms used for estimating antiretroviral drug activity. Content Type Journal ArticleCategory Clinical and Epidemiological StudyDOI 10.1007/s15010-009-9022-6Authors T. Lorenzen, Hospital St. George Ifi–Institute for Interdisciplinary Medicine Lohmuehlenstrasse 5 20099 Hamburg GermanyI. Walther, Hosp...
Source: Infection - October 14, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Effects of Nucleoside Reverse Transcriptase Inhibitor Backbone on the Efficacy of First-Line Boosted Highly Active Antiretroviral Therapy Based on Protease InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tenofovir/emtricitabine and abacavir/lamivudine are widely used with ritonavir-boosted protease inhibitors as first-line HAART. Is one better than the other? HIV Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 13, 2009 Category: Consumer Health News Tags: HIV/AIDS Source Type: news

The prevalence of hepatitis C virus (HCV) infection in HIV-positive individuals in the UK – trends in HCV testing and the impact of HCV on HIV treatment outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the prevalence of hepatitis C virus (HCV) infection among HIV-positive individuals in the UK, trends in HCV testing and the impact of HCV on HIV treatment outcomes. Trends over time in HCV prevalence were calculated using each patient's most recent HCV status at the end of each calendar year. Logistic regression was used to identify factors associated with having a HCV antibody test, and Cox regression was used to determine whether HCV status was associated with the time to experiencing an immunological response to highly active antiretroviral treatment (HAART), time to virological response and viral rebound. O...
Source: Journal of Viral Hepatitis - October 12, 2009 Category: Infectious Diseases Authors: J. Turner, L. Bansi, R. Gilson, B. Gazzard, J. Walsh, D. Pillay, C. Orkin, A. Phillips, P. Easterbrook, M. Johnson, K. Porter, A. Schwenk, T. Hill, C. Leen, J. Anderson, M. Fisher, C. Sabin Source Type: journals

Efavirenz: a decade of clinical experience in the treatment of HIVEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Efavirenz, a non-nucleoside reverse transcriptase inhibitor, has been an important component of the treatment of HIV infection for 10 years and has contributed significantly to the evolution of highly active antiretroviral therapy (HAART). The efficacy of efavirenz has been established in numerous randomized trials and observational studies in HAART-naive patients, including those with advanced infection. In the ACTG A5142 study, efavirenz showed greater virological efficacy than the boosted protease inhibitor (PI), lopinavir. Efavirenz is more effective as a third agent than unboosted PIs or the nucleoside analogue abacav...
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Maggiolo, F. Tags: Reviews Source Type: journals

The safety of highly active antiretroviral therapy for the HIV-positive pregnant mother and her baby: is 'the more the merrier'?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Highly active antiretroviral therapy (HAART) is frequently indicated for pregnant women both for maternal health and for prevention of mother-to-child HIV transmission, which can be reduced to <1%. Prospective data and large cohort studies have not found any evidence that antiretroviral therapy significantly increases the risk of congenital malformation. Nucleoside analogue reverse transcriptase inhibitors (NRTIs) are, to varying degrees, toxic to mitochondria, and molecular and clinical evidence of mitochondrial toxicity has been reported, albeit rarely, in NRTI-exposed but HIV-uninfected children. However, with NRTI-b...
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Martin, F., Taylor, G. P. Tags: Leading articles Source Type: journals

The effect evaluation of highly active antiretroviral therapy to patients with AIDS in Hubei province of ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary The effects of highly active antiretroviral therapy (HAART) to patients with AIDS in Hubei province of China were investigated in order to provide scientific evidence to reinforce the management of HAART. Self-made questionnaires and descriptive method of epidemiology were used to collect and describe the changes of clinical symptoms, HIV RNA concentration, and immune function of patients with AIDS. After HAART, the effective rate of fever, cough, diarrhea, lymphadenectasis, weight loss, tetter, debility and fungous infection was 92.4%, 90.85%, 92.91%, 90.73%, 93.69%, 89.04%, 92.34%, and 83.1%, respe...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 11, 2009 Category: Research Tags: Journal of Huazhong University of Science and Technology -- Medical Sciences -- Source Type: journals