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Endometriosis: associations with menopause, hormone replacement therapy and cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endometriosis is an estrogen-dependent condition and is characterized by the presence of ectopic endometrial tissue. The pathogenesis of this condition remains an enigma. Endometriosis has well known associations with menopause both in terms of secondary outcomes from medical and surgical therapy in premenopausal women, as well as a natural occurrence/recurrence of the disease in women going through menopause naturally. This review article aims to discuss the current day modalities of management of endometriosis with their pros and cons especially in the context of menopause and cancer. (Source: Menopause International)
Source: Menopause International - November 21, 2009 Category: Primary Care Authors: Palep-Singh, M., Gupta, S. Tags: Reviews Source Type: journals

Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScoresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These new algorithms can predict risk of fracture in primary care populations in the UK without laboratory measurements and are therefore suitable for use in both clinical settings and for self assessment (www.qfracture.org). QFractureScores could be used to identify patients at high risk of fracture who might benefit from interventions to reduce their risk. (Source: BMJ Online First)
Source: BMJ Online First - November 20, 2009 Category: Journals (General) Authors: Hippisley-Cox, J., Coupland, C. Tags: Liver disease, Smoking and tobacco, Epidemiologic studies, General practice / family medicine, Immunology (including allergy), Drugs: cardiovascular system, Menopause (including HRT), Asthma, Connective tissue disease, Degenerative joint disease, Drugs: m Source Type: journals

Don't lose your head over beer claimEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Although this study demonstrated a link between higher alcohol intake and reduced CHD risk, it is has several limitations. Therefore, it cannot be assumed that high levels of alcohol consumption lower the risk of CHD. People are advised not to exceed the recommended daily limits of 2-3 units a day for women and 3-4 units a day for men. Importantly, the study did not take into account any other adverse effects of alcohol, such as the increased risk of liver disease, obesity, pancreatic diseases, certain cancers, possible addiction, depression, accidental injury or reduced judgement in social situations. Further l...
Source: NHS News Feed - November 19, 2009 Category: Consumer Health News Tags: Food/diet Heart/lungs Source Type: news

Vitamin C supplements and the risk of age-related cataract: a population-based prospective cohort study in women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results indicate that the use of vitamin C supplements may be associated with higher risk of age-related cataract among women. PMID: 19923367 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - November 18, 2009 Category: Nutrition Authors: Rautiainen S, Lindblad BE, Morgenstern R, Wolk A Tags: Am J Clin Nutr Source Type: journals

'Confident advice' needed to ease fears over HRTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WOMEN SHOULD be given “confident advice” which allows them to make an “informed choice” about using hormone replacement therapy (HRT) to relieve symptoms of menopause, Irish Menopause Society (IMS) president Dr Barbara O’Beirne has said. (Source: The Irish Times - Health)
Source: The Irish Times - Health - November 17, 2009 Category: Consumer Health News Source Type: news

Hormone replacement therapy after breast cancer: attitudes of women eligible in a randomized trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion A patient's decision to accept or decline participation in the Stockholm trial was influenced by her objective risk of breast cancer recurrence and reflected her attitude to risk, uncertainty and preference to be active in treatment decisions. PMID: 19905900 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Wallberg B, von Schoultz E, Bolund C, Bergh J, Wilking N Tags: Climacteric Source Type: journals

Risk of gynecological cancers in users of estradiol/dydrogesterone or other HRT preparations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This study provides evidence that the risk of developing gynecological cancers with E/D use of several months to a few years is similar to the risks of developing gynecological cancer without HRT or use of other HRT. PMID: 19905903 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Schneider C, Jick SS, Meier CR Tags: Climacteric Source Type: journals

Risk of hypoactive sexual desire disorder and associated factors in a cohort of oophorectomized women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Nearly three out of four women who had undergone bilateral oophorectomy were at risk of suffering HSDD; this risk was increased when less than 5 years since surgical menopause had elapsed. The use of hormone replacement therapy was associated with lower HSDD risk. PMID: 19905904 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Castelo-Branco C, Palacios S, Combalia J, Ferrer M, Traveria G Tags: Climacteric Source Type: journals

LEI (Lack of tEstosterone Impact) survey in a clinical sample with surgical menopause.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These data suggest that women experience significant vaginal dryness and low sexual desire and report a significant distress in the relationship with their partner after surgical menopause. Sexual counseling is mandatory in order to discuss potential therapeutic strategies, including testosterone use. PMID: 19905905 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Nappi RE, Lello S, Melis GB, Albani F, Polatti F, Genazzani AR Tags: Climacteric Source Type: journals

Hormone Replacement Beneficial in Younger Postmenopausal WomenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pooled data from controlled trials involving more than 16,000 women indicate that hormone replacement therapy reduces mortality in younger postmenopausal women, researchers report in the November issue of The American Journal of Medicine. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 13, 2009 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Source Type: news

Less HRT, Fewer Cases of Possible Breast Cancer PrecursorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As hormone use declined, so did incidence of abnormal cells in milk ducts, study finds Source: HealthDay Related MedlinePlus Topics: Breast Cancer, Breast Diseases, Hormone Replacement Therapy (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - November 12, 2009 Category: Consumer Health News Source Type: consumer

Is the Wii Fit a new-generation tool for improving balance, health and well-being? A pilot study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Activity fostered by Wii Fit showed an immediate effect on balance and strength that needs confirmation by statistically powered studies. PMID: 19905991 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - November 12, 2009 Category: Geriatrics Authors: Nitz JC, Kuys S, Isles R, Fu S Tags: Climacteric Source Type: journals

Abnormalities of thyroid function in Japanese patients with metastatic renal cell carcinoma treated with sorafenib: A prospective evaluation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to characterize features of thyroid dysfunction in Japanese patients with metastatic renal cell carcinoma (RCC) who were treated with sorafenib. We performed a prospective observational study including 69 Japanese patients who were diagnosed as having metastatic RCC refractory to cytokine therapy and subsequently treated with sorafenib for at least 12 weeks. Thyroid function was assessed before and every 4 weeks after the initiation of sorafenib treatment. Of the 69 patients, 23 (33.3%) did not show any biochemical thyroid abnormality, while the remaining 46 (67.7%) developed hypothyroidism....
Source: Urologic Oncology - November 12, 2009 Category: Urology & Nephrology Authors: Miyake H, Kurahashi T, Yamanaka K, Kondo Y, Muramaki M, Takenaka A, Inoue TA, Fujisawa M Tags: Urol Oncol Source Type: journals

Hormone Therapy Victims Win Important AppealEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On November 2, 2009, the United States Court of Appeals for the Eighth Circuit issued its long-awaited decision in Scroggin v. Wyeth (Case No. 08-2555). The decision gives the green light for federal trials on Wyeth’s and Pfizer’s hormone therapy (http://www.hkllp.com/hormone-replacement-therapy/) drugs. In affirming judgment on a jury verdict of compensatory damages, the federal appellate court rejected the defendants’ claims that plaintiffs like Donna Scroggin cannot prove that hormone therapy caused their breast cancer. Erik Walker of Hissey Kientz, LLP (http://www.hkllp.com/) in Austin, Texas handled ...
Source: PRWeb: Medical Pharmaceuticals - November 11, 2009 Category: Pharmaceuticals Source Type: news

Estradiol Alters Cell Growth in Nonmalignant Colonocytes and Reduces the Formation of Preneoplastic Lesions in the Colon.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Numerous clinical and animal studies show that hormone replacement therapy reduces the risk of colon tumor formation. However, the majority of experiments have shown that estradiol (E(2)) does not inhibit the growth of malignantly transformed colon epithelia. As such, the presented studies focused on evaluating the effects of E(2) in noncancerous colonocytes. E(2) treatments (0-10 nmol/L) reduced cell growth and increased apoptotic activity in young adult mouse colonocytes (YAMC), a nonmalignant cell line, in a dose-responsive manner. These effects were lost in the YAMC-Ras cells, an isogenic cell line with a single ma...
Source: Cell Research - November 10, 2009 Category: Cytology Authors: Weige CC, Allred KF, Allred CD Tags: Cancer Res Source Type: journals

Hormone replacement therapy and breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of postmenopausal hormone treatment has decreased over time in the United States, which scientists suggest may play a key role in the declining rate of atypical ductal hyperplasia, a known risk factor for breast cancer. "Postmenopausal hormone therapy is linked to increased rates of non-malignant breast biopsies, and early and late stages of cancer. Atypical ductal hyperplasia is linked to the use of postmenopausal hormone therapy and its rates have decreased with the decline in use of this therapy," said researcher Tehillah Menes, M.D., who was the chief of breast service in the Department of Surgery at Elmhurst H...
Source: Medicineworld.org: New Article Alert - November 9, 2009 Category: Consumer Health News Source Type: info

Breast Cancer Deception Month: Hiding the Truth beneath a Sea of Pink, Part VEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) As we near the end of Breast Cancer Awareness Month, once again our country has been awash from shore to shore in a sea of pink - from pink ribbons and donation boxes to pink products, charity promotions, celebrities by the score and even pink cleats on NFL players. Tragically, most people are unaware of the dark history of Breast Cancer Awareness Month (BCAM) and of the players past and present who have misused it to direct people and funds away from finding a true cure, while covering up their own roles in causing and profiting from cancer.In this installment of the series, we will examine the dangers of ov...
Source: NaturalNews.com - November 8, 2009 Category: Consumer Health Advice Source Type: news

Obesity and Angiolymphatic Invasion in Primary Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion In this large sample of invasive breast cancers, obesity was independently associated with the presence of angiolymphatic invasion. Higher rates of angiolymphatic invasion among obese women may account in part for poorer outcomes among obese women with breast cancer. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-009-0797-6Authors Erin F. Gillespie, University of Michigan Medical School Ann Arbor MI USAMelony E. Sorbero, RAND Corporation Pittsburgh PA USADavid A. Hanauer, University of Michigan Comprehensive Cancer Center Department of Pediatrics, Bioinformatics Core...
Source: Annals of Surgical Oncology - November 7, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Breast tenderness could be warning signEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Q: I took bioidentical hormone replacement therapy (BHRT) to handle my horrible hot flashes. After taking it for three months, I started having pains in my breasts. A mammogram did not show any problems, but the recommendation was made that I stop... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - November 7, 2009 Category: American Health Source Type: news

Hormone Therapy May Lower Mortality in Younger WomenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Younger postmenopausal women on hormone replacement therapy may have a lower risk of mortality than women undergoing no treatment, according to the results of a Bayesian meta-analysis published in the November issue of the American Journal of Medicine. (Source: Modern Medicine)
Source: Modern Medicine - November 6, 2009 Category: Journals (General) Source Type: info

Endothelial Progenitor Cells in Subclinical Hypothyroidism: The Effect of Thyroid Hormone Replacement Therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: SCH predicted lower EPC count, which improved with T4 treatment, independent of other CV risk factors, providing additional evidence that T4 replacement may improve CV risk in SCH. PMID: 19897678 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 6, 2009 Category: Endocrinology Authors: Shakoor SK, Aldibbiat A, Ingoe LE, Campbell SC, Sibal L, Shaw J, Home PD, Razvi S, Weaver JU Tags: J Clin Endocrinol Metab Source Type: journals

Reductions in use of hormone replacement therapy: effects on Swedish breast cancer incidence trends only seen after several yearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined breast cancer incidence trends in Sweden between 1997 and 2007, a period characterized by a drop in the use of HRT. Incidence trends were assessed using data from three population-based Regional Clinical Registries on breast cancer covering 2/3 of the Swedish population. Information on HRT sales was obtained from national pharmacy data. The prevalence of HRT use in age group 50–59 years decreased from a peak of 36% in 1999 to 27% in 2002 and further to 9% in 2007. Incidence rates of breast cancer in women 50 years and older increased between 1997 and 2003. A significant decrease in incidence be...
Source: Breast Cancer Research and Treatment - November 5, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals

Estimates of overdiagnosis of invasive breast cancer associated with screening mammographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Overdiagnosis of invasive breast cancer attributable to mammography screening appears to be substantial. Our estimates are similar to recent estimates from other screening programmes. Overdiagnosis merits greater attention in research and in clinical and public health policy making. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-009-9459-zAuthors Stephen Morrell, University of Sydney School of Public Health Sydney NSW 2006 AustraliaAlexandra Barratt, University of Sydney School of Public Health Sydney NSW 2006 AustraliaLes Irwig, University of Sydney School of Public ...
Source: Cancer Causes and Control - November 5, 2009 Category: Cancer & Oncology Tags: Cancer Causes and Control Source Type: journals

Oestradiol assays: fitness for purpose?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this review we discuss the analytical inadequacies of oestradiol assays in relation to the clinical requirements for performing them, and make recommendations for their improvement. The measurement of oestradiol can be requested in a number of clinical scenarios (precocious puberty, infertility, assisted conception, hormone replacement therapy). The very wide dynamic range of oestradiol concentrations is a huge challenge for routine assays, which they are unlikely to meet on theoretical as well as practical grounds. The EQA performance of oestradiol assays in terms of trueness, comparability, recovery and analytical sen...
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Middle, J. G, Kane, J. W Tags: Review Article Source Type: journals

Influence of hormone replacement therapy on eccentric exercise induced myogenic gene expression in postmenopausal womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hormone replacement therapy (HRT) is used in postmenopausal women to relieve symptoms of menopause and prevent osteoporosis. We sought to evaluate changes in mRNA expression of key myogenic factors in postmenopausal women taking and not taking HRT following a high-intensity eccentric resistance exercise. Fourteen postmenopausal women were studied and included 6 control women not using HRT (59 ± 4 years, 63 ± 17 kg) and 8 women using traditional HRT (59 ± 4 yr, 89 ± 24 kg). Both groups performed 10 sets of 10 maximal eccentric repetitions of single-leg extension on a Cybex dynamometer at 60°/...
Source: Journal of Applied Physiology - November 4, 2009 Category: Physiology Authors: Dieli-Conwright, C. M., Spektor, T. M., Rice, J. C., Sattler, F. R., Schroeder, E. T. Tags: ARTICLES Source Type: journals

AACE Issues New Medical Guidelines For Proper And Ethical Use Of Growth HormoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The American Association of Clinical Endocrinologists (AACE) released new medical guidelines for the accurate diagnosis and effective ethical treatment of growth hormone deficiency in affected patients. Growth hormone replacement therapy has proven useful for children and adults with scientifically proven growth hormone deficiency. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 4, 2009 Category: Consumer Health News Tags: Endocrinology Source Type: news

Are Bioidentical Hormones Safe?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Our expert helps clinicians respond to women who request compounded bioidentical hormone replacement therapy. Medscape Nurses (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 2, 2009 Category: Consumer Health News Tags: Nursing Source Type: news

Hormone Replacement Therapy Decreases Mortality In Younger Postmenopausal Woman According To StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An article published in the November 2009 issue of The American Journal of Medicine, reports that researchers conducting a meta-analysis of the available data using Bayesian methods concluded that hormone replacement therapy (HRT) almost undoubtedly decreases mortality in younger postmenopausal women. For over sixty years, HRT has been in widespread use to treat menopausal estrogen deficiency. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 2, 2009 Category: Consumer Health News Tags: Women's Health / Gynecology Source Type: news

Early Age at Menarche Associated with Cardiovascular Disease and Mortality.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Early age at menarche (before age 12 yr) was associated with increased risk of cardiovascular disease events, cardiovascular disease mortality, and overall mortality in women, and this association appeared to be only partly mediated by increased adiposity. PMID: 19880785 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 30, 2009 Category: Endocrinology Authors: Lakshman R, Forouhi NG, Sharp SJ, Luben R, Bingham SA, Khaw KT, Wareham NJ, Ong KK Tags: J Clin Endocrinol Metab Source Type: journals

Hormone replacement therapy decreases mortality in some womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hormone replacement treatment (HRT) to treat menopausal estrogen deficiency has been in widespread use for over 60 years. Several findings based on observation over the years showed that HRT use by younger postmenopausal women was linked to a significant reduction in total mortality; available evidence supported the routine use of HRT to increase longevity in postmenopausal women. However, the 2002 publication of a major study, the Women's Health Initiative (WHI), indicated increased risk for certain outcomes in older women, without increasing mortality. This sparked debate regarding potential benefits or harm of HRT. In a...
Source: Medicineworld.org: New Article Alert - October 29, 2009 Category: Consumer Health News Source Type: info

Hormone Replacement Therapy Decreases Mortality In Younger Postmenopausal WomanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hormone replacement therapy (HRT) to treat menopausal estrogen deficiency has been in widespread use for over 60 years. Several observational studies over the years showed that HRT use by younger postmenopausal women was associated with a significant reduction in total mortality; available evidence supported the routine use of HRT to increase longevity in postmenopausal women. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 29, 2009 Category: Consumer Health News Tags: Menopause Source Type: news

Hormone Replacement Therapy Decreases Mortality In Younger Postmenopausal Woman, Study ShowsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several observational studies over the years showed that HRT use by younger postmenopausal women was associated with a significant reduction in total mortality. A major 2002 study indicated increased risk for certain outcomes in older women, without increasing mortality. This sparked debate regarding HRT. In a new study, researchers conducted a meta-analysis of available data using Bayesian methods and concluded that HRT almost certainly decreases mortality in younger postmenopausal women. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 29, 2009 Category: Science Source Type: news

[Review] Management of endometrial cancer in Asia: consensus statement from the Asian Oncology Summit 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the available evidence for optimum management of endometrial cancer and how management strategies can be applied in Asian countries with different levels of health-care resource availability and economic development. An overview of the literature for endometrial-cancer screening, diagnosis, and management is discussed. Consensus statements are formulated on the basis of basic, limited, enhanced, and maximum health-care resource availability, using the framework provided by the Breast Health Global Initiative. (Source: The Lancet Oncology)
Source: The Lancet Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Siriwan Tangjitgamol, Benjamin O Anderson, Hui Ti See, Chawalit Lertbutsayanukul, Nakarin Sirisabya, Tarinee Manchana, Arunachalam Ilancheran, Khai Mun Lee, Siew Eng Lim, Yin-Nin Chia, Efren Domingo, Young-Tak Kim, Chyong-Huey Lai, Ahmad Zailani Hatta Moh Tags: Review Source Type: journals

Long-term prevention with hormone-replacement therapy after the menopause: which women should be targeted?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women's Health , November 2009, Vol. 5, No. 6, Pages 637-647. (Source: Future Medicine: Women's Health)
Source: Future Medicine: Women's Health - October 28, 2009 Category: OBGYN Tags: article Source Type: journals

Study shows hormone replacement therapy decreases mortality in younger postmenopausal womanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Elsevier Health Sciences) Several observational studies over the years showed that HRT use by younger postmenopausal women was associated with a significant reduction in total mortality. A major 2002 study indicated increased risk for certain outcomes in older women, without increasing mortality. This sparked debate regarding HRT. In an article published in the November 2009 issue of the American Journal of Medicine, researchers conducted a meta-analysis of available data using Bayesian methods and concluded that HRT almost certainly decreases mortality in younger postmenopausal women. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - October 28, 2009 Category: Global & Universal Source Type: news

Anthropometry, Body Fat, and Venous Thromboembolism. A Danish Follow-Up Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions-All measurements of obesity are predictors of the risk for VTE. Positive associations were found between VTE and body weight, body mass index, waist circumference, hip circumference, and total body fat mass. PMID: 19858417 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - October 26, 2009 Category: Cardiology Authors: Severinsen MT, Kristensen SR, Johnsen SP, Dethlefsen C, Tjønneland A, Overvad K Tags: Circulation Source Type: journals

Breast Tenderness During Hormone Replacement Therapy Linked To Elevated Cancer RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women who developed new-onset breast tenderness after starting estrogen plus progestin hormone replacement therapy were at significantly higher risk for developing breast cancer than women on the combination therapy who didn't experience such tenderness, according to a new UCLA study. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - October 24, 2009 Category: Cancer & Oncology Source Type: news

Nutri5(R) And Brain Health Related To Treatment Of Menopausal SymptomsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Earlier this year, the BBC reported that "HRT - Hormone Replacement Therapy - can shrink women's brains"1, after a study was published which showed that brain volume in women taking HRT was smaller in two key areas involved in thinking and memory. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 23, 2009 Category: Consumer Health News Tags: Menopause Source Type: news

Suboptimal management of severe menopausal symptoms by Nigerian Gynaecologists: a call for mandatory continuing medical education for physicians.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The result revealed that most Nigerian Gynaecologists prefer reassurance and anxiolytics for managing severe menopausal symptoms instead of evidence-based effective therapies. A policy of mandatory continuing medical education for Nigerian physicians is recommended to ensure evidence-based management of gynaecological problems, including menopause. (Source: BioMed Central)
Source: BioMed Central - October 22, 2009 Category: Journals (General) Authors: Peter Nkwo Source Type: journals

Comparative effects of continuous combined hormone therapy and tibolone on body composition in postmenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The effect of tibolone on body composition is favorable and therefore tibolone may be regarded as an alternative to continuous combined hormone therapy in postmenopausal women. PMID: 19848555 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - October 22, 2009 Category: Geriatrics Authors: Ziaei S, Moaya M, Faghihzadeh S Tags: Climacteric Source Type: journals

Alcohol consumption and breast tumor mitochondrial DNA mutationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Mitochondrial DNA (mtDNA) mutations are frequent in breast tumors, but the etiology of these mutations is unknown. We hypothesized that these mutations are associated with exposures that affect oxidative stress such as alcohol metabolism. Using archived tumor blocks from incident breast cancer cases in a case control study, the Western New York Exposures and Breast Cancer (WEB) study, analysis of mtDNA mutations was conducted on 128 breast cancer cases selected based on extremes of alcohol intake. Temporal temperature gradient gel electrophoresis (TTGE) was used to screen the entire mtDNA genome and...
Source: Breast Cancer Research and Treatment - October 21, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals

Perception of risk of adverse drug reactions: a 3-year follow-up of a cohort of medical studentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous studies have pointed out the question of effective training and information to health professionals on pharmacovigilance. The lack of training is known to induce inadequate use of drugs and noncompliance of patients. Pharmacology teaching is performed in the third year of medical studies at the Toulouse Faculty of Medicine. The aim of the study was to investigate the perception of risk of adverse drug reactions (ADRs) by medical students at the end of the one year pharmacology course and two years later, after clinical training period. Sixty-seven students were interviewed in May 2005 and in October 2007. Visual a...
Source: Fundamental and Clinical Pharmacology - October 20, 2009 Category: Drugs & Pharmacology Authors: Geneviève Durrieu, C. Hurault, C. Damase-Michel, J.L. Montastruc Source Type: journals

Testosterone Prescriptions Up DramaticallyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Middle-aged men, responding to recent TV ads that blamed decreased virility and moodiness on low levels of testosterone, have bombarded their doctors with requests for male hormone replacement therapy. About 3.3 million testosterone prescriptions were... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - October 20, 2009 Category: American Health Source Type: news

Testosterone Prescriptions UpEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Middle-aged men, responding to recent TV ads that blamed decreased virility and moodiness on low levels of testosterone, have bombarded their doctors with requests for male hormone replacement therapy. About 3.3 million testosterone prescriptions were... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - October 20, 2009 Category: American Health Source Type: news

Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Several adipocytokines, such as leptin or adiponectin, are associated with obesity and the risk for breast cancer. Adiopcyte fatty acid binding-protein (A-FABP) is another protein found in adipose tissue; therefore, we investigated the association of A-FABP with the occurrence and prognosis of breast cancer. In our study, 200 women attending the University of Ulm for breast surgery between the years 2005 and 2007 were included; 159 had histologically confirmed breast cancer; 41 had histologically confirmed benign lesions. Serum levels of A-FABP, leptin, and adiponectin were measured, and their relat...
Source: Breast Cancer Research and Treatment - October 20, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals

Aromatase Inhibitor-Induced Carpal Tunnel Syndrome: Results From the ATAC Trial [Breast Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Although the use of anastrozole is associated with a greater incidence of CTS, it is rare, and most cases were of mild to moderate intensity and short duration. CTS has little impact on the overall risk-to-benefit ratio for the use of anastrozole in postmenopausal women with early breast cancer. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Sestak, Sapunar, Cuzick Tags: Epidemiology, Chemoprevention studies Breast Cancer Source Type: journals

Estrogen dose: the cardiovascular impact.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the main concerns from the large secondary and primary prevention cardiovascular trials such as the Heart and Estrogen/progestin Replacement Study and the Women's Health Initiative (WHI) study was that there appeared to be an increased risk of coronary events in the first years of usage. These findings were initially surprising bearing in mind that observational trials had previously shown benefit. Subsequent analyses have confirmed that the risks were primarily in the over-seventies age group. In the younger age groups (50-59 years), there was a trend towards reduction of risk and a significant reduction in all...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Panay N Tags: Climacteric Source Type: journals

Type and route of estrogen administration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hormone replacement therapy (HRT) can be administered orally and non-orally. Providing equivalent doses are given, all forms of HRT can equally relieve menopausal symptoms and prevent bone loss and osteoporosis. Different routes of administration will have differing metabolic effects, with oral HRT producing a hepatic first-pass effect not seen with non-oral HRT. The first-pass effect can produce benefits including larger reductions in low density lipoprotein cholesterol, lipoprotein(a) and insulin resistance, and larger increases in high density lipoprotein cholesterol. Unwanted effects are seen in increases in trigly...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Stevenson JC Tags: Climacteric Source Type: journals

Coronary heart disease and hormone replacement therapy after the menopause.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The discordance in coronary heart disease (CHD) outcome between randomized, controlled trials and observational studies of hormone replacement therapy (HRT) is likely the result of the dissimilar cohorts studied. This observation led to the formation of the timing hypothesis that benefits and risks of HRT depend upon age of HRT initiation and/or time of HRT initiation in relation to menopause. This hypothesis has been supported with data from large, randomized, controlled trials that have studied HRT and selective estrogen receptor modulators (SERMs) in the prevention of CHD. Initiation of HRT in women <60 years of ...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Hodis HN, Mack WJ Tags: Climacteric Source Type: journals

Comparative effects of conventional vs. novel hormone replacement therapy on blood pressure in postmenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Menopause is commonly characterized by an increase in blood pressure. Higher blood pressure may partially explain the elevated risk for cardiovascular events observed in postmenopausal women. There is a graded relationship between blood pressure and cardiovascular risk which extends to levels of blood pressure well below 140/90 mmHg, the classical established blood pressure limit for the diagnosis of hypertension. Despite this knowledge and the wide availability of consensus treatment guidelines for hypertension, high blood pressure remains untreated or poorly treated in many postmenopausal patients. It is clear that n...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Preston RA Tags: Climacteric Source Type: journals