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Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel homologue of insect defensin designated lucifensin (Lucilia defensin) was purified from the extracts of various tissues (gut, salivary glands, fat body, haemolymph) of green bottle fly (Lucilia sericata) larvae and from their excretions/secretions. The primary sequence of this peptide of 40 residues and three intramolecular disulfide bridges was determined by ESI-QTOF mass spectrometry and Edman degradation and is very similar to that of sapecin and other dipteran defensins. We assume that lucifensin is the key antimicrobial component that protects the maggots when they are exposed to the highly infectious envi...
Source: Cellular and Molecular Life Sciences : CMLS - November 18, 2009 Category: Cytology Authors: Ceřovský V, Zďárek J, Fučík V, Monincová L, Voburka Z, Bém R Tags: Cell Mol Life Sci Source Type: journals

Disruption of Staphylococcus epidermidis biofilms by medicinal maggot Lucilia sericata excretions/secretions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic infections are commonly associated with biofilms formed by bacteria such as Staphylococcus epidermidis. With the increase in antibiotic resistant bacteria, maggot debridement therapy has been reintroduced for the treatment of chronic wounds. Studies have shown that the excretion/ secretions (ES) of Lucilia sericata larvae (maggots) contain many bioactive compounds which may contribute to the efficacy of maggot therapy. The present study evaluates the effect of L. sericata ES on the formation and disruption of S. epidermidis 1457 and 5179-R1 biofilms. These strains employ either polysaccharide intercellular adhe...
Source: The International Journal of Artificial Organs - October 24, 2009 Category: Transplant Surgery Authors: Harris LG, Bexfield A, Nigam Y, Rohde H, Ratcliffe NA, Mack D Tags: Int J Artif Organs Source Type: journals

Maggot excretions/secretions induces human microvascular endothelial cell migration through AKT1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Maggot therapy is a simple and highly successful method for healing of infected and necrotic wounds. The increasing evidences indicate that Maggot excretions/secretions (ES) plays important roles in the wounds healing process. But the precise molecular mechanisms remain undefined. Herein, we investigated if ES induced cell migration during wound healing process using microvascular endothelial cells (HMEC-1) as model, and this effect was associated with the activation of AKT1 and ERK1/2. Wound healing and transwell migration assays were performed to study the effects of ES on HMEC-1 cell migration. Our data showed that ...
Source: Molecular Biology Reports - September 15, 2009 Category: Molecular Biology Authors: Wang SY, Wang K, Xin Y, Lv DC Tags: Mol Biol Rep Source Type: journals

Larval therapy as a palliative treatment for severe arteriosclerotic gangrene on the feetEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with ischaemia treated with LT. Inguinal revascularization was performed on a 69-year-old man with critical limb ischaemia, diabetes mellitus, heart failure and end-stage renal disease. Areas of dry black malodorous gangrene remained on the distal areas of the feet after surgery and the patient's poor health did not allow any additional surgery. The patient was referred to the dermatology department for LT. Although patients are usually given this treatment as inpatients, the patient requested treatment at home. After the first LT, there was a marked reduction in odour. The gangrene needed repeated appl...
Source: Clinical And Experimental Dermatology - July 2, 2009 Category: Dermatology Authors: A. Nordström, C. Hansson, L. Karlström Source Type: journals

Larval therapy vs hydrogel for leg ulcers: similar benefits, costsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - April 10, 2009 Category: Health Management Tags: Research article Source Type: journals

Do maggots have an influence on bacterial growth? A study on the susceptibility of strains of six different bacterial species to maggots of Lucilia sericata and their excretions/secretionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There is no direct antibacterial effect of maggots and/or ES in vitro, however in clinical observations maggot therapy is successful. More research is needed to focus on possible indirect antibacterial activity, such as an immune-related effect. (Source: Journal of Tissue Viability)
Source: Journal of Tissue Viability - April 9, 2009 Category: Internal Medicine Authors: G. Cazander, K.E.B. van Veen, A.T. Bernards, G.N. Jukema Source Type: journals

Larval therapy vs hydrogel for leg ulcers: similar benefits, costs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 7 (Source: PharmacoEconomics & Outcomes News)
Source: PharmacoEconomics & Outcomes News - April 7, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Maggot Therapy Similar To Standard Care For Leg UlcersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Larval (maggot) therapy has similar health benefits and costs compared with a standard treatment for leg ulcers, find two studies published on bmj.com today. Leg ulcers are chronic wounds most commonly caused by diseased veins in the legs. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 22, 2009 Category: Consumer Health News Tags: Dermatology Source Type: news

Maggot therapy similar to standard care for leg ulcersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Larval (maggot) therapy has similar health benefits and costs compared with a standard treatment for leg ulcers, find two studies (Source: Nursing in Practice)
Source: Nursing in Practice - March 21, 2009 Category: Nursing Source Type: news

Maggots No Better Than Gel For Wound Healing, StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A UK study found that maggots (larval therapy) were no quicker at helping leg ulcers to heal or get rid of bacteria than the standard treatment based on hydrogel, and they were on the whole more painful, although they did speed up removal of dead tissue (debridement). (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)
Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today - March 20, 2009 Category: Infectious Diseases Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Maggot Therapy Comparable to Standard Care for Leg UlcersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As a method of debridement for leg ulcers, treatment with maggots, also known as larval therapy, is generally comparable in effectiveness and costs to hydrogel dressings, according to the results of two studies conducted by the VenUS II research team. Reuters Health Information (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - March 20, 2009 Category: Drugs & Pharmacology Tags: Dermatology Source Type: info

Maggot Therapy: No Advantage for Leg UlcersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
YORK, England (MedPage Today) -- For treating leg ulcers, maggot therapy was as effective as standard therapy with hydrogel, a randomized trial showed. (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - March 20, 2009 Category: American Health Source Type: news

Health News of the DayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day.Meniscus tears increase knee osteoarthritis risk by 3-fold for minor tear and 8-fold for severe meniscal tear http://is.gd/o5fHLive maggot therapy is more painful and does not lead to faster healing of leg ulcers than standard treatment. http://is.gd/o6rsLarval therapy did not improve rate of healing of leg ulcers or reduce bacterial load compared with hydrogel, BMJ: http://is.gd/o6PwThe seemingly mild head injury that kille...
Source: Clinical Cases and Images - March 20, 2009 Category: Journals (General) Tags: Health News of the Day Source Type: info

Larval Debridement Therapy Effective for Leg UlcersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In patients with sloughy or necrotic leg ulcers, debridement with larval therapy leads to similar outcomes at a similar cost as standard hydrogel therapy, but it may be associated with reduced time to debridement and more pain, according to two studies published March 19 in BMJ Online First. (Source: Modern Medicine)
Source: Modern Medicine - March 20, 2009 Category: Journals (General) Source Type: info

Maggots for Leg Ulcers? Maybe NotEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Maggot therapy -- using live maggots to eat away dead tissue -- is more painful and does not lead to faster healing of leg ulcers than standard treatment, a study shows. (Source: WebMD Health)
Source: WebMD Health - March 20, 2009 Category: Consumer Health News Source Type: news

Maggot therapy hope 'premature'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Using maggots to treat leg ulcers is no better than standard treatment with a gel, a UK trial has found. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 20, 2009 Category: Consumer Health News Tags: Health Source Type: news

Monarch Labs announces first wound dressing in US specifically for maggot therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Monarch Labs) Monarch Labs announced today the market launch of its new, proprietary wound dressing specifically designed to make maggot therapy more easy, quick and simple to administer. Monarch Labs has been allowed by the US Food and Drug Administration to produce and marketing this new wound care device under the trade name, LeFlap. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 10, 2009 Category: Infectious Diseases Source Type: news

An overview of maggot therapy used on chronic wounds in the community.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Maggot debridement therapy was re-introduced to clinical practice in the UK in the mid 1990s. While at first it was slow to be used by health care professionals, in recent times the therapy has enjoyed an upsurge in use, which has benefited both patients and the NHS. At the same time there has been some resistance to use from clinicians. This led to the introduction of a new presentation of maggots for use in wound care, which has proved popular with both patients and clinicians and has led to increasing use of maggot therapy for the treatment of chronic wounds. PMID: 19452661 [PubMed - in process] (Source: British...
Source: British Journal of Community Nursing - March 1, 2009 Category: Nursing Authors: Jones M Tags: Br J Community Nurs Source Type: journals

Maggot Therapy for Wound ManagementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract available (Source: Advances in Skin & Wound Care)
Source: Advances in Skin & Wound Care - January 1, 2009 Category: Dermatology Tags: Departments: Research Forum Source Type: journals

Maggot Therapy for Wound Management.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 25DOI: 10.1097/01.ASW.0000343730.76308.6aAuthors: Hunter, Susan RN, MSN; Langemo, Diane PhD, RN, FAAN; Thompson, Patricia RN, MS; Hanson, Darlene RN, MS; Anderson, Julie PhD, RN, CCRC (Source: Advances in Skin & Wound Care)
Source: Advances in Skin & Wound Care - December 20, 2008 Category: Dermatology Tags: HTML PDF (165 K) Source Type: journals

[Maggot therapy with Lucilia sericata for debridement of chronic wounds.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18929922 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - October 1, 2008 Category: Dermatology Authors: Cartier E, Combemale P Tags: Ann Dermatol Venereol Source Type: journals

[Maggot therapy with Lucilia sericata for debridement of chronic wounds]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18929922 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - October 1, 2008 Category: Dermatology Authors: Cartier E, Combemale P Tags: Ann Dermatol Venereol Source Type: journals

[PostScript] Maggot therapy for periocular skin graft failure in the immunocompromised patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - June 3, 2008 Category: Opthalmology Authors: Gericke, A, Pitz, S Tags: PostScript Source Type: journals

Exploring patient perceptions of larval therapy as a potential treatment for venous leg ulcerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Health Expectations, Volume 11, Issue 2, Page 148-159, June 2008. AbstractObjectives To explore patient preferences and acceptability of two forms of larval therapy (‘bagged’ and ‘loose’).Background Larval therapy is frequently used to treat patients with leg ulcers. However, patient preferences and acceptability of ... (Source: Health Expectations)
Source: Health Expectations - May 21, 2008 Category: Health Management Tags: article Source Type: journals

Selective antimicrobial activity of maggots against pathogenic bacteria.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, larval therapy is highly recommended, particularly for the treatment of wounds infected with Gram-positive bacteria, like Staphylococcus aureus, but less so for wounds infected with Gram-negative bacteria, especially Proteus spp. and Pseudomonas spp. strains. Bacteria from the genus Vagococcus were resistant to the maggot excreta/secreta. PMID: 18436596 [PubMed - indexed for MEDLINE] (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - May 1, 2008 Category: Microbiology Authors: Jaklic D, Lapanje A, Zupancic K, Smrke D, Gunde-Cimerman N Tags: J Med Microbiol Source Type: journals

The value of debridement and Vacuum-Assisted Closure (V.A.C.) Therapy in diabetic foot ulcersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Treatment of diabetic foot ulcers includes a number of different regimes such as glycaemic control, re-vascularization, surgical, local wound treatment, offloading and other non-surgical treatments. Although considered the standard of care, the scientific evidence behind the various debridements used is scarce. This presentation will focus on debridement and V.A.C. Therapy, two treatments widely used in patients with diabetes and foot ulcers.A review of existing literature on these treatments in diabetic foot ulcers, with focus on description of the various types of debridements used, the principles behind negative pressur...
Source: Diabetes/Metabolism Research and Reviews - April 7, 2008 Category: Endocrinology Authors: Magnus Eneroth, William H. van Houtum Source Type: journals

[PostScript] Maggot therapy following orbital exenterationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 16, 2007 Category: Opthalmology Authors: Gericke, A., Hoffmann, E. M, Pitz, S., Pfeiffer, N. Tags: PostScript Source Type: journals

Maggot Therapy for Problematic Wounds: Uncommon and Off-label Applications.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers investigated the efficacy and safety of maggot therapy use as an adjunct to other methods of surgical and nonsurgical wound care and for off-label indications, including debridement, disinfection, and stimulation of healing.Page: 602DOI: 10.1097/01.ASW.0000284943.70825.a8Authors: Sherman, Ronald A. MD, MSc; Shapiro, Charles E. MD, FACS; Yang, Ronald M. MD (Source: Advances in Skin & Wound Care)
Source: Advances in Skin & Wound Care - November 2, 2007 Category: Dermatology Tags: Abstract HTML PDF (2.129 M) Source Type: journals

Maggot debridement therapy in chronic wound care.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS. Maggot debridement therapy has been shown to be a safe and effective means of chronic wound management. However, there are a number of limitations when considering its local applicability. Future development of the delivery system may help to overcome some of these limitations and improve its acceptability. PMID: 17914145 [PubMed - in process] (Source: Hong Kong Med J)
Source: Hong Kong Med J - October 1, 2007 Category: Journals (General) Authors: Chan DC, Fong DH, Leung JY, Patil NG, Leung GK Tags: Hong Kong Med J Source Type: journals

[Reviews] Larval therapy from antiquity to the present day: mechanisms of action, clinical applications and future potentialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When modern medicine fails, it is often useful to draw ideas from ancient treatments. The therapeutic use of fly larvae to debride necrotic tissue, also known as larval therapy, maggot debridement therapy or biosurgery, dates back to the beginnings of civilisation. Despite repeatedly falling out of favour largely because of patient intolerance to the treatment, the practice of larval therapy is increasing around the world because of its efficacy, safety and simplicity. Clinical indications for larval treatment are varied, but, in particular, are wounds infected with multidrug-resistant bacteria and the presence of signific...
Source: Postgraduate Medical Journal - June 5, 2007 Category: Journals (General) Authors: Whitaker, I. S, Twine, C., Whitaker, M. J, Welck, M., Brown, C. S, Shandall, A. Tags: Reviews Source Type: journals

Frogs + Maggots = New Weapons in the War on MRSAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Drug resistant bacteria, as the Bard would tell us, is a "plague on both your hospitals." As bacterial drug resistance grows, so does the motivation to find new ways to fight this epidemic. The Guardian is reporting that researchers from Manchester University have found great success treating MRSA infected ulcers with...maggots. Maggots of the common bluebottle can fight off the superbug MRSA, researchers from Manchester University announced today. They discovered that when free-range larvae from the insect were applied to the MRSA-infected foot ulcers of 13 diabetic patients, they cleared up the infection in all but ...
Source: Medgadget - May 3, 2007 Category: Technology Consultants Authors: Josh Tags: Medicine Source Type: info

Larval Therapy in Wound Management: A ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Debridement with maggots: Overcoming the yuk factor to promote wound healing. International journal of clinical practice (Source: Medscape FamilyMedicine Headlines)
Source: Medscape FamilyMedicine Headlines - April 24, 2007 Category: Primary Care Tags: Internal Medicine Source Type: info

New Wound Dressing May Lead To Maggot Therapy Without The MaggotsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists in the United Kingdom have developed a new wound dressing that could bring the benefits of maggot therapy to patients without putting live Greenbottle fly (blowfly) larvae into non-healing wounds. The joint research project of Stephen Britland from Bradford University and David Pritchard of Nottingham University included colleagues from the Bradford-based biotechnology company AGT Sciences Ltd. [click link for full article] (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)
Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today - October 10, 2006 Category: Infectious Diseases Source Type: news

Patient acceptability of larval therapy for leg ulcer treatment: a randomised survey to inform the sample size calculation of a randomised trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We found no evidence of widespread resistance to the utilisation of larval therapy from patients regardless of the method of larval therapy containment. These methods have the potential to inform sample size calculations where there are concerns of patient acceptability. (Source: BioMed Central)
Source: BioMed Central - September 1, 2006 Category: Journals (General) Authors: Emily S Petherick, Susan O'Meara, Karen Spilsbury, Cynthia P Iglesias, E Andrea Nelson and David J Torgerson Source Type: journals

Maggot Therapy: The Science and Implication for CAM Part II--Maggots Combat InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Maggot therapy employs the use of freshly emerged, sterile larvae of the common green-bottle fly, Phaenicia (Lucilia) sericata, and is a form of artificially induced myiasis in a controlled clinical situation. Maggot therapy has the following three core beneficial effects on a wound: debridement, disinfection and enhanced healing. In part II of this review article, we discuss clinical infections and the evidence supporting the potent antibacterial action of maggot secretions. Enhancement of wound healing by maggots is discussed along with the future of this highly successful, often controversial, alternative treatment. (So...
Source: Evidence-based Complementary and Alternative Medicine - July 17, 2006 Category: Complementary Medicine Authors: Nigam, Y., Bexfield, A., Thomas, S., Ratcliffe, N. A. Source Type: journals

Maggot Therapy: The Science and Implication for CAM Part I--History and Bacterial ResistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is now a universally acknowledged fact that maggot therapy can be used successfully to treat chronic, long-standing, infected wounds, which have previously failed to respond to conventional treatment. Such wounds are typically characterized by the presence of necrotic tissue, underlying infection and poor healing. Maggot therapy employs the use of freshly emerged, sterile larvae of the common green-bottle fly, Phaenicia (Lucilia) sericata, and is a form of artificially induced myiasis in a controlled clinical situation. In this review article, we will discuss the role of maggots and their preparation for clinical use. M...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2006 Category: Complementary Medicine Authors: Nigam, Y., Bexfield, A., Thomas, S., Ratcliffe, N. A. Source Type: journals

Letter to the editor: Maggot therapy in "lower-extremity hospice" wound care.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 16415289 [PubMed - indexed for MEDLINE] (Source: Journal of the American Podiatric Medical Association)
Source: Journal of the American Podiatric Medical Association - January 1, 2006 Category: Podiatry Authors: Steenvoorde P, Jacobi CE, Oskam J Tags: J Am Podiatr Med Assoc Source Type: journals

Maggot therapy in the treatment of wounds of exposed knee prosthesesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
International Journal of Dermatology Volume 0, Issue 0 (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - August 24, 2004 Category: Dermatology News Source Type: journals

A new clinical trial of the effect of larval therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article has not been subject to peer review. PMID: 15709358 [PubMed - indexed for MEDLINE] (Source: Journal of Tissue Viability)
Source: Journal of Tissue Viability - July 1, 2004 Category: Internal Medicine Authors: Raynor P, Dumville J, Cullum N Tags: J Tissue Viability Source Type: journals

The antimicrobial activity of maggots: in-vivo results.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the literature maggot therapy is discussed as a promising and potent form of debridement therapy. The number of maggots needed to debride a wound is estimated at 10 per cm2, and more in case of a higher percentage of necrosis or slough. In the authors' hospital, from March 1999 to May 2002, 16 patients were successfully treated with maggot therapy. The average maggot treatment time was 27 days, with an average of seven maggot changes. Most patients were treated for osteomyelitis, with trauma being the leading aetiological factor. In accordance with in-vitro findings, maggot therapy was found to be more effective in ...
Source: Journal of Tissue Viability - July 1, 2004 Category: Internal Medicine Authors: Steenvoorde P, Jukema GN Tags: J Tissue Viability Source Type: journals