Non-alcoholic fatty liver disease: pathogenesis and models
Am J Transl Res. 2024 Feb 15;16(2):387-399. eCollection 2024.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a complex disease characterized by a massive accumulation of lipids in the liver, with a continuous progression of simple steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Non-alcoholic fatty liver disease is associated with obesity, insulin resistance, and metabolic syndrome; it is a severe public health risk and is currently the most common liver disease of the world. In addition to the fatty infiltration of the liver in non-alcoholic fatty liver disease patients, the f...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Hanxiang Zhong Jiayong Dong Liye Zhu Jiaxi Mao Junfeng Dong Yuanyu Zhao You Zou Meng Guo Guoshan Ding Source Type: research

Myocardial mechano-energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity
CONCLUSIONS: Increased BMI is not an obligate determinant for reduced myocardial MEEi. Other known components of metabolic syndrome rather than increased BMI contributed to reduced myocardial MEEi.PMID:38467153 | DOI:10.1002/oby.24006 (Source: Obesity)
Source: Obesity - March 11, 2024 Category: Eating Disorders & Weight Management Authors: Chiara Maria Assunta Cefalo Alessia Riccio Teresa Vanessa Fiorentino Elena Succurro Gaia Chiara Mannino Maria Perticone Angela Sciacqua Francesco Andreozzi Giorgio Sesti Source Type: research

Tirzepatide, a dual incretin analog, is a boon in metabolic syndrome: an editorial
Ann Med Surg (Lond). 2024 Feb 5;86(3):1249-1250. doi: 10.1097/MS9.0000000000001782. eCollection 2024 Mar.NO ABSTRACTPMID:38463093 | PMC:PMC10923294 | DOI:10.1097/MS9.0000000000001782 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Mainak Bardhan Pooja Gokhale Priyanka Roy Tithishri Kundu Ayush Anand Source Type: research

Ca2+ Depletion in the ER Causes Store-Operated Ca2+ Entry via the TRPC6 Channel in Mouse Brown Adipocytes
In this study, we investigated how Ca2+ depletion from the ER elicits SOCE in mouse brown adipocytes using fluorometry of intracellular Ca2+ concentration ([Ca2+]i). The administration of cyclopiazonic acid (CPA), a reversible sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump blocker in the ER, caused an increase in [Ca2+]i. Moreover, CPA induced SOCE was suppressed by the administration of a Ca2+ free Krebs solution and the transient receptor potential canonical 6 (TRPC6) selective blockers 2-APB, ML-9 and GsMTx-4 but not Pico145, which blocks TRPC1/4/5. Administration of TRPC6 channel agonist 1-oleoyl-2-acet...
Source: Physiological Research - March 11, 2024 Category: Physiology Authors: R Hayato T Matsumoto Y Higure Source Type: research

Non-alcoholic fatty liver disease: pathogenesis and models
Am J Transl Res. 2024 Feb 15;16(2):387-399. eCollection 2024.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a complex disease characterized by a massive accumulation of lipids in the liver, with a continuous progression of simple steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Non-alcoholic fatty liver disease is associated with obesity, insulin resistance, and metabolic syndrome; it is a severe public health risk and is currently the most common liver disease of the world. In addition to the fatty infiltration of the liver in non-alcoholic fatty liver disease patients, the f...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Hanxiang Zhong Jiayong Dong Liye Zhu Jiaxi Mao Junfeng Dong Yuanyu Zhao You Zou Meng Guo Guoshan Ding Source Type: research

Myocardial mechano-energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity
CONCLUSIONS: Increased BMI is not an obligate determinant for reduced myocardial MEEi. Other known components of metabolic syndrome rather than increased BMI contributed to reduced myocardial MEEi.PMID:38467153 | DOI:10.1002/oby.24006 (Source: Obesity)
Source: Obesity - March 11, 2024 Category: Eating Disorders & Weight Management Authors: Chiara Maria Assunta Cefalo Alessia Riccio Teresa Vanessa Fiorentino Elena Succurro Gaia Chiara Mannino Maria Perticone Angela Sciacqua Francesco Andreozzi Giorgio Sesti Source Type: research

Non-alcoholic fatty liver disease: pathogenesis and models
Am J Transl Res. 2024 Feb 15;16(2):387-399. eCollection 2024.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a complex disease characterized by a massive accumulation of lipids in the liver, with a continuous progression of simple steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Non-alcoholic fatty liver disease is associated with obesity, insulin resistance, and metabolic syndrome; it is a severe public health risk and is currently the most common liver disease of the world. In addition to the fatty infiltration of the liver in non-alcoholic fatty liver disease patients, the f...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Hanxiang Zhong Jiayong Dong Liye Zhu Jiaxi Mao Junfeng Dong Yuanyu Zhao You Zou Meng Guo Guoshan Ding Source Type: research

Myocardial mechano-energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity
CONCLUSIONS: Increased BMI is not an obligate determinant for reduced myocardial MEEi. Other known components of metabolic syndrome rather than increased BMI contributed to reduced myocardial MEEi.PMID:38467153 | DOI:10.1002/oby.24006 (Source: Obesity)
Source: Obesity - March 11, 2024 Category: Eating Disorders & Weight Management Authors: Chiara Maria Assunta Cefalo Alessia Riccio Teresa Vanessa Fiorentino Elena Succurro Gaia Chiara Mannino Maria Perticone Angela Sciacqua Francesco Andreozzi Giorgio Sesti Source Type: research

Non-alcoholic fatty liver disease: pathogenesis and models
Am J Transl Res. 2024 Feb 15;16(2):387-399. eCollection 2024.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a complex disease characterized by a massive accumulation of lipids in the liver, with a continuous progression of simple steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Non-alcoholic fatty liver disease is associated with obesity, insulin resistance, and metabolic syndrome; it is a severe public health risk and is currently the most common liver disease of the world. In addition to the fatty infiltration of the liver in non-alcoholic fatty liver disease patients, the f...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Hanxiang Zhong Jiayong Dong Liye Zhu Jiaxi Mao Junfeng Dong Yuanyu Zhao You Zou Meng Guo Guoshan Ding Source Type: research

Myocardial mechano-energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity
CONCLUSIONS: Increased BMI is not an obligate determinant for reduced myocardial MEEi. Other known components of metabolic syndrome rather than increased BMI contributed to reduced myocardial MEEi.PMID:38467153 | DOI:10.1002/oby.24006 (Source: Obesity)
Source: Obesity - March 11, 2024 Category: Eating Disorders & Weight Management Authors: Chiara Maria Assunta Cefalo Alessia Riccio Teresa Vanessa Fiorentino Elena Succurro Gaia Chiara Mannino Maria Perticone Angela Sciacqua Francesco Andreozzi Giorgio Sesti Source Type: research

Non-alcoholic fatty liver disease: pathogenesis and models
Am J Transl Res. 2024 Feb 15;16(2):387-399. eCollection 2024.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a complex disease characterized by a massive accumulation of lipids in the liver, with a continuous progression of simple steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Non-alcoholic fatty liver disease is associated with obesity, insulin resistance, and metabolic syndrome; it is a severe public health risk and is currently the most common liver disease of the world. In addition to the fatty infiltration of the liver in non-alcoholic fatty liver disease patients, the f...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Hanxiang Zhong Jiayong Dong Liye Zhu Jiaxi Mao Junfeng Dong Yuanyu Zhao You Zou Meng Guo Guoshan Ding Source Type: research

Myocardial mechano-energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity
CONCLUSIONS: Increased BMI is not an obligate determinant for reduced myocardial MEEi. Other known components of metabolic syndrome rather than increased BMI contributed to reduced myocardial MEEi.PMID:38467153 | DOI:10.1002/oby.24006 (Source: Obesity)
Source: Obesity - March 11, 2024 Category: Eating Disorders & Weight Management Authors: Chiara Maria Assunta Cefalo Alessia Riccio Teresa Vanessa Fiorentino Elena Succurro Gaia Chiara Mannino Maria Perticone Angela Sciacqua Francesco Andreozzi Giorgio Sesti Source Type: research

Non-alcoholic fatty liver disease: pathogenesis and models
Am J Transl Res. 2024 Feb 15;16(2):387-399. eCollection 2024.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a complex disease characterized by a massive accumulation of lipids in the liver, with a continuous progression of simple steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Non-alcoholic fatty liver disease is associated with obesity, insulin resistance, and metabolic syndrome; it is a severe public health risk and is currently the most common liver disease of the world. In addition to the fatty infiltration of the liver in non-alcoholic fatty liver disease patients, the f...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Hanxiang Zhong Jiayong Dong Liye Zhu Jiaxi Mao Junfeng Dong Yuanyu Zhao You Zou Meng Guo Guoshan Ding Source Type: research

Myocardial mechano-energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity
CONCLUSIONS: Increased BMI is not an obligate determinant for reduced myocardial MEEi. Other known components of metabolic syndrome rather than increased BMI contributed to reduced myocardial MEEi.PMID:38467153 | DOI:10.1002/oby.24006 (Source: Obesity)
Source: Obesity - March 11, 2024 Category: Eating Disorders & Weight Management Authors: Chiara Maria Assunta Cefalo Alessia Riccio Teresa Vanessa Fiorentino Elena Succurro Gaia Chiara Mannino Maria Perticone Angela Sciacqua Francesco Andreozzi Giorgio Sesti Source Type: research

Non-alcoholic fatty liver disease: pathogenesis and models
Am J Transl Res. 2024 Feb 15;16(2):387-399. eCollection 2024.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a complex disease characterized by a massive accumulation of lipids in the liver, with a continuous progression of simple steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Non-alcoholic fatty liver disease is associated with obesity, insulin resistance, and metabolic syndrome; it is a severe public health risk and is currently the most common liver disease of the world. In addition to the fatty infiltration of the liver in non-alcoholic fatty liver disease patients, the f...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Hanxiang Zhong Jiayong Dong Liye Zhu Jiaxi Mao Junfeng Dong Yuanyu Zhao You Zou Meng Guo Guoshan Ding Source Type: research