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This page shows you the latest news and research items in this category.

SALL‐4 is a marker of embryonal subtype of hepatoblastoma
ConclusionsSALL4 is expressed in blastemal tumors particularly in embryonal subtype of hepatoblastomas. This expression of SALL4 in hepatoblastoma has to be known by pathologists to avoid misdiagnosis.This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - May 14, 2013 Category: Pathology Authors: Viviane Gnemmi, Emmanuelle Leteurtre, Hélène Sudour‐Bounnange, Louise Devisme, Catherine Guettier, David Buob, Xavier Leroy Tags: Short Report Source Type: research

Mixed epithelial and stromal tumor—cytologic findings of an unusual renal cyst
(Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - February 27, 2013 Category: Pathology Authors: Lucy E. DeFanti, Laurentia Nodit Tags: Images in Cytology Source Type: research

Analysis of national and single-center incidence and survival after liver transplantation for hepatoblastoma: New trends and future opportunities
Background: Liver transplantation (LTx) for hepatoblatoma appears to be increasing. Favorable tumor histology is increasingly linked to survival after surgical resection and could also determine posttransplantation outcomes.Methods: To evaluate national trends in tumor and LTx incidence as the basis for observations at some LTx centers, and determinants of survival after LTx for hepatoblastoma, we queried the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) registry representing 9.451% of the U.S. population (1975–2007), the United Network for Organ Sharing (UNOS, 1988–2010, n = 332), and...
Source: Surgery - January 17, 2013 Category: Surgery Authors: Ruy J. Cruz, Sarangarajan Ranganathan, George Mazariegos, Kyle Soltys, Navdeep Nayyar, Qing Sun, Geoffrey Bond, Peter H. Shaw, Kimberly Haberman, Lakshmanan Krishnamurti, J. Wallis Marsh, Abhinav Humar, Rakesh Sindhi Tags: Surgical Outcome Research Source Type: research

Editorial Comment from Dr Nagashima to Malignant mixed epithelial and stromal tumor of the kidney: Report of the first male case
(Source: International Journal of Urology)
Source: International Journal of Urology - October 8, 2012 Category: Urology & Nephrology Authors: Yoji Nagashima Tags: Editorial Comment Source Type: research

Paratesticular cystadenomas with ovarian stroma, metaplastic serous müllerian epithelium, and male adnexal tumor of probable wolffian origin: A series of 5 hitherto poorly recognized testicular tumors
We present 5 paratesticular tumors, which manifested ovarian-type stroma and various serous müllerian epithelial structures including serous fallopian-like epithelium and proliferations closely mimicking cystic serous borderline tumors of the ovary. In addition, 3 of the tumors in our series revealed a solid epithelial component, which was morphologically and immunohistochemically similar to so called “female adnexal tumor of probable wolffian origin,” which is a rare neoplasm described so far only in the female genital tract, retroperitoneum, and the pelvic cavity. In analogy with mixed epithelial and stromal tumors ...
Source: Annals of Diagnostic Pathology - September 27, 2012 Category: Pathology Authors: Michal Michal, Dmitry V. Kazakov, Denisa Kacerovska, Naoto Kuroda, Eva Lovric, David L. Wachter, Abbas Agaimy, Ondrej Hes Tags: Original Contributions Source Type: research

Mesothelioma of the tunica vaginalis with BerEp4 and LeuM1 expression: identification of cytoplasmic tonofilaments by electron microscopy is a key diagnostic feature
Paratesticular mesothelioma is a rare tumour, representing only 0.3–5% of all mesotheliomas; approximately 223 cases have been described to date.1 Morphologically, most paratesticular mesotheliomas are epithelial, or mixed epithelial and sarcomatoid; with papillary, tubulopapillary or solid architectural patterns.2 3 Papillary mesotheliomas can be difficult to distinguish from papillary serous carcinoma on morphological grounds alone and usually require immunohistochemical and ultrastructural studies. Mesotheliomas are typically positive for calretinin, CK5/6, D2-40, vimentin and thrombomodulin but negative for BerEp...
Source: Journal of Clinical Pathology - September 22, 2012 Category: Pathology Authors: Shelton, D., Dalal, N. Tags: PostScript Source Type: research

Editorial Comment to Malignant mixed epithelial and stromal tumor of the kidney: Report of the first male case
(Source: International Journal of Urology)
Source: International Journal of Urology - September 19, 2012 Category: Urology & Nephrology Authors: Rodolfo Montironi, Liang Cheng, Antonio Lopez‐Beltran, Marina Scarpelli Tags: Editorial Comment Source Type: research

Malignant mixed epithelial and stromal tumor of the kidney: Report of the first male case
We report the first case of malignant mixed epithelial and stromal tumor of the kidney in a male patient. A 67‐year‐old Japanese man receiving hormonal therapy for prostatic cancer was found to have a right renal cystic tumor and underwent right nephrectomy. Histologically, the tumor was composed of benign epithelial and stromal cells in addition to malignant undifferentiated stromal cells. Immunohistochemically, the malignant stromal component was positive for cluster of differentiation 99 and B‐cell lymphoma 2, but no chimeric transcripts for synovial sarcoma were identified. Finally, a diagnosis of malignant m...
Source: International Journal of Urology - September 19, 2012 Category: Urology & Nephrology Authors: Toshiro Suzuki, Shiro Hiragata, Kyoko Hosaka, Toshio Oyama, Naoto Kuroda, Ondrej Hes, Michal Michal Tags: Case Report Source Type: research

Editorial Comment from Dr Montironi et al. to Malignant mixed epithelial and stromal tumor of the kidney: Report of the first male case
(Source: International Journal of Urology)
Source: International Journal of Urology - September 19, 2012 Category: Urology & Nephrology Authors: Rodolfo Montironi, Liang Cheng, Antonio Lopez‐Beltran, Marina Scarpelli Tags: Editorial Comment Source Type: research

Changing treatment and outcome of children with hepatoblastoma: analysis of a single center experience over the last 20 years
Conclusion: Liver transplantation is a good option for children with advanced HBL. Early referral of children with potentially unresectable tumors to centers where combined treatment (chemotherapy, surgery including LTx) is available is crucial. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - July 1, 2012 Category: Surgery Authors: Hor Ismail, Dorota Broniszczak, Piotr Kaliciński, Bożenna Dembowska-Bagińska, Danuta Perek, Joanna Teisseyre, Przemyslaw Kluge, Andrzej Kościesza, Agnieszka Lembas, Malgorzata Markiewicz Tags: Original Articles Source Type: research

Beyond renal cell carcinoma: rare and unusual renal masses
Abstract The vast majority of primary renal masses represent clear cell or papillary renal cell carcinomas, angiomyolipomas, or transitional cell carcinomas. However, a number of more rare masses can also be encountered, many of which can be very difficult to differentiate from these more common entities based on their imaging features. These uncommon entities include metanephric adenoma, epithelioid angiomyolipoma, medullary renal cell carcinomas, multilocular cystic nephroma, hemangiopericytoma, hemangioma, leiomyoma, leiomyosarcoma, solitary fibrous tumor, renal plasmacytomas, and mixed epithelial and str...
Source: Abdominal Imaging - May 13, 2012 Category: Radiology Tags: Abdominal Imaging Source Type: research

Renal angiomyoadenomatous tumor
We report a case of a 40-year-old woman with renal angiomyoadenomatous tumor, a rare neoplasm with only 6 previous cases reported in the literature. Unlike our case, most tumors have been identified in middle-aged males; they present as well-circumscribed, encapsulated tan-brown masses with variably prominent cystic areas. Microscopically, the tumors have a variably thick leiomyomatous capsule, which invaginates into the tumor and intermixes with tubules or solid nests of clear epithelial cells. The epithelial cells have low-grade basally oriented nuclei, and their basement membranes are intimately linked to a labyrinthine...
Source: Annals of Diagnostic Pathology - April 25, 2012 Category: Pathology Authors: Charanjeet Singh, Ayse Tuba Karagulle Kendi, J. Carlos Manivel, Stefan E. Pambuccian Tags: Radiologic-Pathologic Correlations Source Type: research

Clinicopathologic features of the mixed epithelial and mesenchymal type metaplastic breast carcinoma with myoepithelial differentiation in a subset of six cases.
Abstract Metaplastic carcinoma (MC) of the breast, consisting of epithelial and mixed epithelial-mesenchymal tumors, are extremely rare human neoplasms. They are mostly detected between the 5th and 7th decade and have an unfavorable prognosis. Therefore, it is of utmost important to find out the behavior and also the immunohistochemical (IHC) profile of these tumors. In the current study, the aim was to examine 6 cases of MC with detailed clinico-pathological variables of cancer, follow-up and IHC profile of several antigens. The following immunohistochemical markers were used: MNF116, vimentin, CD10, smooth muscle...
Source: Pathology, Research and Practice - March 15, 2012 Category: Pathology Authors: Yigit S, Pehlivan FS, Evcim G, Etit D Tags: Pathol Res Pract Source Type: research

Hepatoblastoma—An attempt of histological subtyping on fine‐needle aspiration material
AbstractHepatoblastoma (HB) is classified into epithelial, mixed (epithelial/mesenchymal), and small‐cell (anaplastic) type. Wnt/β‐catenin pathway plays a key role in hepatic development, regeneration, and tumorigenesis, and HB is known to present β‐catenin mutations (50–90%). The present study was undertaken to delineate the cytomorphologic features of HB and to evaluate the feasibility of subtyping of HB on fine‐needle aspiration cytology (FNAC). The expression of β‐catenin in these tumors was also evaluated both of histopathologic sections and on the aspirated material. Thirty‐three cases with fine‐ne...
Source: Diagnostic Cytopathology - February 23, 2012 Category: Pathology Authors: Adarsh BarwadNalini GuptaKirti GuptaArvind RajwanshiRam Kumar MarwahaK. L. N. RaoPranab DeyRadhika SrinivasanRaje Nijhawan Tags: Original Article Source Type: research

Unusual Presentation of Rare Case of Papillary Adenofibroma of Cervix in a Young Woman
We report the case of a large polypoidal mass per vagina occupying the whole pelvis in a young woman. Preoperative biopsy showed benign epithelial and mullerian mesenchymal components suggestive of mullerian adenofibroma. Total hysterectomy with bilateral salpingectomy was done. The diagnosis of papillary adenofibroma of cervix was made. The total surgery assured complete excision and permitted adequate sampling to exclude malignancy. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research

Mixed epithelial and stromal tumor of the kidney (MEST) simulating an upper tract TCC.
We present a rare and interesting case of a mixed epithelial and stromal tumour (MEST) of the kidney. The case is unique as it involves a male patient with no history of hormonal therapy presenting with a filling defect in the renal collecting system and positive urine cytology. The patient was diagnosed with transitional cell carcinoma of the renal pelvis and subjected to nephroureterectomy, which revealed a solid tumour arising from the lower calyces and extending into the renal pelvis and upper ureter. Pathology revealed a MEST. The patient was disease-free at the 6-month follow-up. PMID: 22396379 [PubMed - in proce...
Source: Canadian Urological Association Journal - February 1, 2012 Category: Urology & Nephrology Authors: Sountoulides P, Koptsis M, Metaxa L, Theodosiou A, Kikidakis D, Filintatzi C, Paschalidis K Tags: Can Urol Assoc J Source Type: research

Mixed Epithelial and Stromal Tumor of the Kidney in a 14-Year-Old Boy
Urol Int (DOI:10.1159/000334335) (Source: Urologia Internationalis : Last 20 articles)
Source: Urologia Internationalis : Last 20 articles - January 9, 2012 Category: Urology & Nephrology Source Type: research

Potential biomarkers for hepatoblastoma: Results from the SIOPEL-3 study
Abstract: Hepatoblastoma (HB) is a rare malignant liver tumour found in infants. Many heterogenous histological tumour subtypes exist. Although survival rates have improved dramatically in recent years with the use of platinum-based chemotherapy, there still exists a subset of HB that does not respond to treatment. There are currently no tumour biomarkers in use and in this study we aim to evaluate potential biomarkers to aid identification of relapse cases that would otherwise be overlooked by current prognostication. This may identify patients that would benefit from more aggressive therapy and could improve overall surv...
Source: European Journal of Cancer - December 2, 2011 Category: Cancer & Oncology Authors: Rachel Purcell, Margaret Childs, Rudolf Maibach, Carina Miles, Clinton Turner, Arthur Zimmermann, Piotra Czauderna, Michael Sullivan Tags: Pediatric oncology Source Type: research

Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype
Activation of Raf/Ras/mitogen-activated protein kinase (MEK)/mitogen-activated protein kinase signaling and elevated expression of membrane type-1 matrix metalloproteinase (MT1-MMP) are associated with von Hippel–Lindau gene alterations in renal cell carcinoma. We postulated that the degree of MEK activation was related to graded expression of MT1-MMP and the resultant phenotype of renal epithelial tumors. Madin Darby canine kidney epithelial cells transfected with a MEK1 expression plasmid yielded populations with morphologic phenotypes ranging from epithelial, mixed epithelial/mesenchymal to mesenchymal. Clones wer...
Source: Carcinogenesis - November 18, 2011 Category: Cancer & Oncology Authors: Mahimkar, R., Alfonso-Jaume, M. A., Cape, L. M., Dahiya, R., Lovett, D. H. Tags: CANCER BIOLOGY Source Type: research

A Novel Method for Isolating Individual Cellular Components from the Adult Human Distal Lung.
Abstract A variety of lung diseases, such as pulmonary emphysema and idiopathic pulmonary fibrosis, develop in the lung alveoli. There are multiple cell types localized in the alveoli, including epithelial, mesenchymal and endothelial cells. These resident cells participate in the pathogenesis of lung diseases in various ways. To clearly elaborate the mechanism(s) of these pathologic processes, cell-type specific analyses of lung diseases are required. However, no method exists for individually isolating the different types of cells found in the alveoli. Here, we report the development of a FACS-based method for th...
Source: Am J Respir Cell Mol... - October 27, 2011 Category: Respiratory Medicine Authors: Fujino N, Kubo H, Ota C, Suzuki T, Suzuki S, Yamada M, Takahashi T, He M, Suzuki T, Kondo T, Yamaya M Tags: Am J Respir Cell Mol Biol Source Type: research

Mixed epithelial stromal tumor of the kidney
Hariprasada D Rao, S Sriram, BH Srinivas, Sundaram Challa, Ram Reddy Ch, Pisapati MurthyIndian Journal of Urology 2011 27(2):284-287In recent years, a rare distinctive kidney tumor composed of a mixture of stroma and epithelium with solid and cystic architecture has been recognized, which has to be distinguished from other renal neoplasms. The term mixed epithelial and stromal tumor was first introduced by Michal and Syrucek in 1998. [1] The vast majority of cases show a benign course without tumor recurrence. Here, we present a case of this entity, found incidentally. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 7, 2011 Category: Urology & Nephrology Authors: Hariprasada D RaoS SriramBH SrinivasSundaram ChallaRam Reddy ChPisapati Murthy Source Type: research

Mixed Epithelial and Stromal Tumor of the Kidney
A 53-year-old female with a history of urolithiasis, smoking and estrogen use underwent noncontrast computerized tomography (CT) of the abdomen to evaluate for the presence of renal or ureteral calculi. A cystic lesion was noted in the left kidney. A subsequent triphasic CT of the abdomen revealed a 5.1 × 5.5 cm cystic mass with numerous thick enhancing internal septations and a central enhancing nodule (). The mass was located in the upper pole of the left kidney, and a small portion of the mass herniated into the renal pelvis and splayed the upper pole collecting system (). No calcifications were present in the mass and...
Source: The Journal of Urology - June 16, 2011 Category: Urology & Nephrology Authors: Cecil G. Wood, David D. Casalino Tags: Radiology Page Source Type: research

Nonserous Ovarian Epithelial Tumors
Abstract: This review covers the group of relatively uncommon nonserous ovarian epithelial tumors. The authors focus on the group's distinctiveness from the much more common serous tumors and show the similarities across entities. Diagnostic criteria that separate the different entities are currently being debated. Particular problems include the reproducible diagnosis of high-grade endometrioid, transitional cell, mixed epithelial and undifferentiated carcinomas. Furthermore, despite recognition that most malignant mucinous tumors involving ovary represent metastases from extraovarian primary sites, many misdiagnoses stil...
Source: Surgical Pathology Clinics - February 28, 2011 Category: Pathology Authors: Guangming Han, Robert A. Soslow Tags: Ovary, Fallopian Tube, and Peritoneum Source Type: research

Laparoendoscopic single-site nephrectomy using a modified umbilical incision and a home-made transumbilical port.
Conclusion: LESS nephrectomy using a home-made port and modified umbilical incision is feasible with both minimal incision and cost-effective. Our technique may be more useful for extirpative procedures in which a specimen needs to be removed intact, because incision length can be freely adjusted. Prospective comparisons are warranted to more clearly elucidate the utility of this surgical technique. PMID: 21319351 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 22, 2011 Category: Universities & Medical Training Authors: Yu HS, Ham WS, Rha KH, Han SW, Choi YD, Han WK, Chang WS Tags: Yonsei Med J Source Type: research

Mixed epithelial and stromal tumor of the kidney with elevated serum level of cancer antigen 125.
We report a rare case of a 45-year-old woman with a palpable abdominal mass and elevated serum level of serum cancer antigen 125, who was not receiving hormones or contraceptive agents. Abdominal magnetic resonance imaging revealed a large multilocular cystic tumor that arose in the left central kidney. Nephrectomy was performed under the initial impression of cystic renal cell carcinoma; however, a diagnosis of mixed epithelial and stromal tumor was confirmed according to pathological and immunohistochemical findings. Serum level of cancer antigen 125 returned to normal after 1 month postoperatively and no recurrence was ...
Source: J Formos Med Assoc - January 31, 2011 Category: Journals (General) Authors: Liu CH, Yu CC, Chang CR, Wu TT, Huang JK Tags: J Formos Med Assoc Source Type: research

Carbonic Anhydrase IX Expression in Renal Neoplasms: Correlation With Tumor Type and Grade.
Carbonic anhydrase IX (CAIX), a hypoxia-induced protein, is expressed in some renal tumors. We evaluated its immunohistochemical expression in 317 primary and 42 metastatic renal neoplasms (186 clear cell, 52 papillary, 35 chromophobe, 47 unclassified, and 15 Xp11.2 translocation renal cell carcinomas [RCCs]; 26 oncocytomas; 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were unknown as to whether they were primary or metastatic. We also correlated expression with tumor type and grade. Variable staining was seen in clear cell, papillary, unclassi...
Source: American Journal of Clinical Pathology - November 23, 2010 Category: Pathology Authors: Genega EM, Ghebremichael M, Najarian R, Fu Y, Wang Y, Argani P, Grisanzio C, Signoretti S Tags: Am J Clin Pathol Source Type: research

Giant phyllodes tumor of the breast: a case report
Conclusion To our knowledge, this patient presented one of the biggest phyllodes tumors of breast in all cases reported in English-language publications so far. Content Type Journal ArticleDOI 10.1007/s10330-010-0688-0Authors Dong Xia, Department of General Surgery, The First Affiliated Hospital, Luzhou Medical College, Luzhou, 646000 ChinaHuaiquan Zuo, Department of General Surgery, The First Affiliated Hospital, Luzhou Medical College, Luzhou, 646000 ChinaYi Quan, Department of General Surgery, The First Affiliated Hospital, Luzhou Medical College, Luzhou, 646000 ChinaHongliang Dong, Department of ...
Source: The Chinese-German Journal of Clinical Oncology - November 20, 2010 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: research

Endometrial carcinomas with ambiguous features
Endometrial carcinomas are a heterogenous group of tumors that show variable histologies, molecular abnormalities and clinical outcomes. The idea of rigid distinctions between tumor types is appealing to pathologists, gynecologists, researchers and patients, but in a recent study where high grade endometrial carcinomas were reviewed by three experienced gynecologic pathologists, diagnostic agreement about tumor type was reached in only approximately one half of cases. In general, biologically and clinically validated diagnostic criteria are lacking for high grade endometrial carcinomas and for those that appear mixed epith...
Source: Seminars in Diagnostic Pathology - October 31, 2010 Category: Pathology Authors: Robert A. Soslow Source Type: research

Mixed Epithelial and Stromal Tumor of the Kidney: Radiologic-Pathologic Correlation [Genitourinary Imaging]
Mixed epithelial and stromal tumor (MEST) of the kidney is a rare, typically benign lesion that occurs predominantly in perimenopausal women. At computed tomography (CT), it typically manifests as a multiloculated cystic renal mass with a variable proportion of solid and cystic components and containing internal septa that demonstrate heterogeneous and delayed contrast material enhancement. MEST may mimic a variety of benign and malignant renal lesions, such as adult cystic nephroma, complex renal cyst, and cystic renal cell carcinoma. The preoperative diagnosis of MEST can be problematic, and most cases are treated surgic...
Source: Radiographics recent issues - October 12, 2010 Category: Radiology Authors: Chu, L. C., Hruban, R. H., Horton, K. M., Fishman, E. K. Tags: Oncologic Imaging, Computed Tomography, Genitourinary Radiology Genitourinary Imaging Source Type: research

Mucosal carcinoma of the fallopian tube coexists with ovarian cancer of serous subtype only: a study of Japanese cases
In this study, we sought to examine the coexistence of mucosal carcinoma of the fallopian tube in Japanese ovarian cancer cases. We submitted the fallopian tubes in toto for histological examination in 52 ovarian carcinoma cases and three peritoneal serous carcinoma cases. The ovarian tumors included 12 serous adenocarcinomas, 23 clear cell adenocarcinomas, nine endometrioid adenocarcinomas, three mucinous adenocarcinomas, and four mixed epithelial carcinomas. Mucosal carcinoma of the fallopian tube did not coexist with non-serous adenocarcinoma (n = 40). In contrast, mucosal carcinoma of the fallopian tube was obs...
Source: Virchows Archiv - September 24, 2010 Category: Pathology Tags: Virchows Archiv Source Type: research

Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma : an update.
CONCLUSION: It is difficult to distinguish benign or malignant nature on imaging studies. PMID: 20845287 [PubMed - in process] (Source: Urology Journal)
Source: Urology Journal - September 18, 2010 Category: Urology & Nephrology Authors: Moslemi MK Tags: Urol J Source Type: research

An Unusual Presentation of a Mixed Epithelial and Stromal Tumor in an Elderly Male
This is a case report describing the clinical, surgical, and pathological features of an elderly gentleman who presented with a rare type of renal tumor. Initially managed conservatively, he underwent nephron-sparing surgery. A description of the differential diagnosis is detailed. (Source: TheScientificWorldJOURNAL: Newly published articles.)
Source: TheScientificWorldJOURNAL: Newly published articles. - September 13, 2010 Category: Science Source Type: research

Twelve cases of metaplastic carcinoma of the breast: experience of the university hospital of Fez Morocco
Conclusion This study found a high incidence of MBC compared to Western countries. The tumors occur at an earlier age of onset and are usually diagnosed at a late stage with predominance of squamous cell carcinoma subtype. LN metastases are found in the third case and the tumors are most often basal-like phenotype significantly reducing therapeutic options. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-010-1474-5Authors Kaoutar Znati, Résidence Belair, Immeuble C Appartement 4, Route Immouzzer Fez MoroccoSanaa Chahbouni, HASSAN II University Hospital Department of Path...
Source: Archives of Gynecology and Obstetrics - May 8, 2010 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: research

Cystic Renal Tumors: New Entities and Novel Concepts
Cystic renal neoplasms and renal epithelial stromal tumors are diagnostically challenging and represent some novel tumor entities. In this article, clinical and pathologic features of established and novel entities are discussed. Predominantly cystic renal tumors include cystic nephroma/mixed epithelial and stromal tumor, synovial sarcoma, and multilocular cystic renal cell carcinoma. These entities are own tumor entities of the 2004 WHO classification of renal tumors. Tubulocystic carcinoma and acquired cystic disease-associated renal cell carcinoma are neoplasms with an intrinsically cystic growth pattern. Both tumor typ...
Source: Advances in Anatomic Pathology - April 30, 2010 Category: Pathology Tags: Review Articles Source Type: research

Exophytic benign mixed epithelial stromal tumour of the kidney: case report of a rare tumour entity
Conclusion: MEST represents a distinctive benign tumour entity of the kidney, which affects perimenopausal woman. The tumour should be distinguished from other cystic renal neoplasms. By imaging studies it is difficult to distinguish between a benign or malignant nature of the tumour. Thus, intraoperative frozen section is necessary for conservative surgery, since the overall prognosis is favourable and renal function can be preserved in most cases. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 28, 2010 Category: Pathology Authors: Michael RichterWerner MeyerJens KusterPeter Middel Source Type: research

Immunohistochemical Markers of Value in the Diagnosis of Mesenchymal Lesions of the Female Genital Tract
Abstract: Pure mesenchymal tumors may occur anywhere in the female genital tract, but they are most common in the uterine corpus, leiomyoma being by far the most prevalent. These tumors, and other uncommon mesenchymal lesions within the uterine corpus and elsewhere in the female genital tract, may result in several diagnostic problems. Morphology remains paramount and, in most cases, an unequivocal diagnosis can be made based on examination of the hematoxylin and eosin stained sections, combined with an appreciation of the clinical and gross pathologic features. In difficult cases, immunohistochemistry can significantly co...
Source: Surgical Pathology Clinics - November 30, 2009 Category: Pathology Authors: W. Glenn McCluggage Source Type: research

Mixed epithelial and stromal renal tumour in a 12-year-old boy
Abstract: Mixed epithelial and stromal tumour of the kidney (MESTK) is a rare kidney neoplasm that occurs almost exclusively in perimenopausal women. Long-term oestrogen replacement appears to play a major role in its pathogenesis. Around 70 cases have been described in the international literature, none of which involve male children. Herein, we describe an atypical case of MESTK diagnosed in a 12-year-old prepubertal boy who presented with hematuria. Pathology and immunohistochemistry revealed a typical MESTK. The child was free of disease at 2-year follow up after a partial nephrectomy and tumour excision. (Source: Jour...
Source: Journal of Pediatric Urology - November 8, 2009 Category: Urology & Nephrology Authors: Youssef Teklali, Christian Piolat, Chantal Durand, Bernard Boillot, Dominique Pasquier, Catherine Jacquier, Jean François Dyon Tags: Case Reports Source Type: research

Mixed epithelial and stromal tumour of the kidney: imaging features
To describe the features on ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI) of mixed epithelial and stromal tumours of the kidney. Five women with renal mixed epithelial and stromal tumours (mean age 55.6 years, range 49[ndash]59) who had preoperative imaging were retrospectively analysed. Three ultrasonograms, five contrast-enhanced CT scans, and one contrast-enhanced MRI examination were available for review. Specific imaging features analysed included lesion size, location, enhancement and cystic composition. The presence of calcification, septation, nodularity and a capsule were also...
Source: BJU International - October 9, 2009 Category: Urology & Nephrology Authors: V. Anik Sahni, Koenraad J. Mortele, Jonathan Glickman, Stuart G. Silverman Source Type: research

Intestinal type of mucinous borderline tumor arising from mixed epithelial and stromal tumor of kidney
We report a mucinous borderline tumor arising from a mixed epithelial and stromal tumor of left kidney (MESTK). The patient was an 82-year-old woman who presented with gross hematuria and recurrent urinary tract infection for years. The patient had a cytoscopy with a retrograde pyelogram, which indicated a dilated left kidney with a central mass lesion. Subsequently, she underwent a radical left nephrectomy. Cross-sections of left kidney showed a 4.5 × 3.5 × 1.5 cm ill-defined cystic lesion with mucinous and solid areas. Histologic sections of the lesion showed numerous variable-sized dilated cysts with ...
Source: Virchows Archiv - September 16, 2009 Category: Pathology Tags: Virchows Archiv Source Type: research

Mixed epithelial and stromal tumors of the kidney: an overview.
This article provides a brief overview of the current knowledge of mixed epithelial and stromal tumor of the kidney. PMID: 19722760 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Mohanty SK, Parwani AV Tags: Arch Pathol Lab Med Source Type: research

Adult Extrarenal Wilms' Tumor Mimicking Mixed Epithelial and Stromal Tumor in the Retroperitoneum: A Case Report with Immunohistochemical Study and Review of the Literature.
We report an extremely rare case of adult extrarenal Wilms' tumor (WT) in a 52-year-old woman who presented with fever and abdominal distension. Computed tomography revealed a well-defined mass lesion measuring 15.0 cm in the right retroperitoneum and that was in contact with the right kidney. The mass and kidney were surgically removed. Grossly, the mass was well-defined, measuring 16.3 x 11.0 x 9.8 cm, and appearing grayish-white in color. The border between the mass and the kidney was well-defined. Histologically, the tumor showed a triphasic pattern consisting of stromal, epithelial and blastemal components. The stroma...
Source: Pathology Oncology Research - April 23, 2009 Category: Pathology Authors: Kadota K, Haba R, Kushida Y, Katsuki N, Hayashi T, Miyai Y, Bando K, Taoka R, Kakehi Y Tags: Pathol Oncol Res Source Type: research

2009 update on the classification of renal epithelial tumors in adults
The classification of kidney tumors in adults expands rapidly with new categories recently incorporated. This will result in the modification of the current 2004 World Health Organization (WHO) classification of the adult renal epithelial neoplasms. Emphasis should be placed in defining risk groups categorized as malignant or benign tumors, including a category of tumors with low malignant potential to accommodate recently recognized categories with extremely good prognosis after surgery. Unusual tumors such as familial renal cell carcinoma (RCC), translocation RCC, renal cell carcinoma after neuroblastoma, tubular mucinou...
Source: International Journal of Urology - April 21, 2009 Category: Urology & Nephrology Authors: Antonio Lopez-Beltran, Jose C Carrasco, Liang Cheng, Marina Scarpelli, Ziya Kirkali, Rodolfo Montironi Source Type: research

Mixed epithelial/mesenchymal metaplastic carcinoma (carcinosarcoma) of the breast in BRCA1 carrier.
This report exemplifies that even very uncommon breast tumor types may develop through biallelic inactivation of BRCA1 gene, that has to be considered in the genetic testing settings. PMID: 19350356 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 6, 2009 Category: Cancer & Oncology Authors: Suspitsin EN, Sokolenko AP, Voskresenskiy DA, Ivantsov AO, Shelehova KV, Klimashevskiy VF, Matsko DE, Semiglazov VF, Imyanitov EN Tags: Breast Cancer Source Type: research

Mixed Epithelial and Stromal Tumor of the Kidney
Mixed epithelial and stromal tumor (MEST) of the kidney is a relatively uncommon renal neoplasm composed of stromal and epithelial elements. Examples of this tumor have been reported under various names including cystic hamartoma of the renal pelvis and adult mesoblastic nephroma. MEST demonstrates a marked female predominance (6:1 female-to-male ratio) and, although classically described as a perimenopausal tumor, patient age range is 24 to 84 years and it often affects women with prolonged estrogen exposure. MEST occurs rarely in the male population and it has been associated with androgen deprivation therapy in some cas...
Source: The Journal of Urology - March 17, 2009 Category: Urology & Nephrology Authors: Bryce P. Portier, Donna E. Hansel, Ming Zhou, Gregory T. MacLennan Tags: Pathology Page Source Type: research

Re: Rodolfo Montironi, Roberta Mazzuccelli, Antonio Lopez-Beltran, et al. Cystic Nephroma and Mixed Epithelial and Stromal Tumour of the Kidney: Opposite Ends of the Spectrum of the Same Entity? Eur Urol 2008;54:1237–46
We have read with a great interest the review article by Montironi et al about cystic nephroma (CN) and mixed epithelial and stromal tumor of the kidney (MESTK) . The review was prepared mainly from a pathologic point of view. We would like to add some clinical comments that are important for everyday clinical urologic praxis. At our institution, urologists are very familiar with these ideas because the concept of MESTK was described by our pathologists , and we have also published clinical opinions on these tumors . We would like to make the following recommendations for everyday clinical praxis: (Source: European Urology)
Source: European Urology - January 20, 2009 Category: Urology & Nephrology Authors: Milan Hora, Michal Michal, Ondřej Hes Tags: Letters to the Editor published online Source Type: research

Re: Rodolfo Montironi, Roberta Mazzuccelli, Antonio Lopez-Beltran, et al. Cystic Nephroma and Mixed Epithelial and Stromal Tumour of the Kidney: Opposite Ends of the Spectrum of the Same Entity? Eur Urol 2008;54:1237-46.
PMID: 19167806 [PubMed - as supplied by publisher] (Source: European Urology)
Source: European Urology - January 20, 2009 Category: Urology & Nephrology Authors: Hora M, Michal M, Hes O Tags: Eur Urol Source Type: research

Occurrence of hepatocellular carcinoma after hepatoblastoma resection in an adult with hepatitis C virus.
Hepatoblastoma is a rare malignancy in adults. It is often diagnosed after the appearance of symptoms, therefore, the tumor size tends to be larger. In patients with no indication for a hepatic resection, the prognosis of adult hepatoblastoma is quite poor. A 54-year-old man with hepatitis C virus-associated liver cirrhosis was initially treated with a hepatic resection for a hepatic tumor, 3 cm in diameter. The tumor consisted of osteoid-like and cartilaginous foci, myxomatous stroma, and poorly differentiated hepatocellular carcinomatous cells and was diagnosed as a mixed epithelial and mesenchymal hepatoblastoma. Tw...
Source: Hepatology Research - January 12, 2009 Category: Internal Medicine Authors: Masuda T, Beppu T, Horino K, Komori H, Hayashi H, Okabe H, Ootao R, Horlad H, Baba Y, Miyase S, Takamori H, Baba H Tags: Hepatol Res Source Type: research

Adult Cystic Nephroma and Mixed Epithelial and Stromal Tumor of the Kidney Are the Same Disease Entity: Molecular and Histologic Evidence.
Page: 72DOI: 10.1097/PAS.0b013e3181852105Authors: Zhou, Ming MD, PhD *; Kort, Eric MD +; Hoekstra, Philip MD ++; Westphal, Michael PhD +; Magi-Galluzzi, Cristina MD, PhD *; Sercia, Linda BS *; Lane, Brian MD, PhD *; Rini, Brian MD *; Bukowski, Ronald MD *; Teh, Bin T. MD, PhD + (Source: The American Journal of Surgical Pathology)
Source: The American Journal of Surgical Pathology - January 3, 2009 Category: Pathology Tags: Abstract HTML PDF (859 K) Source Type: research

Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity
We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT). Five cases were retrieved from the consultation files of the authors. Histologic and immunohistochemical features were evaluated. Sequencing analysis of coding region of the VHL gene was carried out in all cases. The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma. Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts. All tubular/glandular structures were lined by a fine capillary network. The epithelial component was positive...
Source: Virchows Archiv - November 20, 2008 Category: Pathology Tags: Virchows Archiv Source Type: research