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This page shows you the latest news and research items in this category.

Denileukin Diftitox plus Total Skin Electron Beam Radiation in Patients with Treatment-refractory Cutaneous T-cell Lymphoma (Mycosis Fungoides): Report of Four Cases.
Abstract Abstract is missing (Letter). PMID: 23756575 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - June 5, 2013 Category: Dermatology Authors: Buder K, Müller PA, Beckmann G, Ugurel S, Bröcker EB, Becker JC Tags: Acta Derm Venereol Source Type: research

Clinicopathological features of mycosis fungoides in patients exposed to Agent Orange during the Vietnam War
Abstract There are no reports on the clinicopathological features of mycosis fungoides (MF) among veterans exposed to Agent Orange, one of the herbicides used during the Vietnam War. To evaluate the clinical, histopathological and genotypic findings of Vietnam War veterans with MF and a positive history of exposure to Agent Orange, we performed a comparative clinicopathological study between MF patients with a history of Agent Orange exposure and those without a history of Agent Orange exposure. Twelve Vietnam War veterans with MF were identified. The mean interval from Agent Orange exposure to diagnosis was 24.5 years (r...
Source: The Journal of Dermatology - June 3, 2013 Category: Dermatology Authors: Min Soo Jang, Jun Gyu Jang, Sang Hwa Han, Jong Bin Park, Dong Young Kang, Sang Tae Kim, Kee Suck Suh Tags: Original Article Source Type: research

Positron emission tomography computed tomography in large cell transformation of mycosis fungoides
(Source: The Journal of Dermatology)
Source: The Journal of Dermatology - June 3, 2013 Category: Dermatology Authors: Thomas Cheng, Florence Loong, Yok‐Lam Kwong Tags: Letter to the Editor Source Type: research

Primary Cutaneous Posttransplant Lymphoproliferative Disorders in Solid Organ Transplant Recipients: A Multicenter European Case Series
Abstract Primary cutaneous posttransplant lymphoproliferative disorders (PTLD) are rare. This retrospective, multicenter study of 35 cases aimed to better describe this entity. Cases were (re)‐classified according to the WHO‐EORTC or the WHO 2008 classifications of lymphomas. Median interval between first transplantation and diagnosis was 85 months. Fifty‐seven percent of patients had a kidney transplant. Twenty‐four cases (68.6%) were classified as primary cutaneous T cell lymphoma (CTCL) and 11 (31.4%) as primary cutaneous B cell PTLD. Mycosis fungoides (MF) was the most common (50%) CTCL subtype. Ten (90.9%) cut...
Source: American Journal of Transplantation - May 29, 2013 Category: Transplant Surgery Authors: D. Seçkin, S. Barete, S. Euvrard, C. Francès, J. Kanitakis, A. Geusau, V. del Marmol, C. A. Harwood, C. M. Proby, I. Ali, A. T. Güleç, E. Durukan, C. Lebbé, M. Alaibac, E. Laffitte, S. Cooper, J. N. Bouwes Bavinck, G. M. Murphy, C. Ferrándiz, C. Mø Tags: Original Article Source Type: research

Mycosis fungoides in plaque stage with pronounced eosinophilic infiltration, folliculotropism, and concomitant invasive squamous cell carcinoma.
Abstract Mycosis fungoides (MF) is a relatively rare cutaneous T-cell malignancy. Only two cases of MF with marked eosinophilia have been reported. In addition, MF with concomitant squamous cell carcinoma (SCC) occurring in the site of MF has not been reported. The author reports herein a very rare case of MF in the plaque stage showing pronounced eosinophilic infiltration, folliculotropic pattern, and in situ development of poorly differentiated squamous cell carcinoma (SCC). A 75-year-old man was found to show high prostate specific antigen (PSA, 13 hg/ml) and prostatic biopsy showed well differentiated prostatic...
Source: International Journal of Clinical and Experimental Pathology - May 25, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Aberrant expression of BCL11B in mycosis fungoides and its potential role in interferon‐induced apoptosis
In conclusion, our study demonstrated the overexpression of BCL11B in MF lesions and its potential relevance to disease progression. In addition, we provided evidence for BCL11B inhibitory approaches as a potential treatment to target chemoresistant tumor cells in advanced MF. (Source: The Journal of Dermatology)
Source: The Journal of Dermatology - May 19, 2013 Category: Dermatology Authors: Xiaoguang Gu, Yang Wang, Gaolei Zhang, Weiwei Li, Ping Tu Tags: Original Article Source Type: research

CD4/CD8 Double-negative Mycosis Fungoides Mimicking Erythema Gyratum Repens in a Patient with Underlying Lung Cancer.
Abstract Absract is missing (Letter). PMID: 23694996 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - May 17, 2013 Category: Dermatology Authors: Nagase K, Shirai R, Okawa T, Inoue T, Misago N, Narisawa Y Tags: Acta Derm Venereol Source Type: research

Photodynamic Therapy in Mycosis Fungoides.
This article reviews the literature and the practical application of photodynamic therapy in mycosis fungoides. PMID: 23664412 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - May 8, 2013 Category: Dermatology Authors: Fernández-Guarino M, Jaén-Olasolo P Tags: Actas Dermosifiliogr Source Type: research

Papular mycosis fungoides: report of two patients, literature review, and conceptual re‐appraisal
Recent reports of 10 patients have proposed a papular variant of mycosis fungoides (MF), characterized by the appearance of papules in the absence of patches and the presence of histopathologic features of classic patch/plaque stage MF. Given the overlapping clinical and pathologic features between this proposed entity and lymphomatoid papulosis (LyP)‐type B, however, the optimal classification for such cases remains somewhat unclear. Herein, two patients are described who presented to the dermatology clinic with persistent erythematous papular eruptions on the trunk, upper and lower extremities and histopathology compat...
Source: Journal of Cutaneous Pathology - May 8, 2013 Category: Pathology Authors: Megan H. Noe, Ashley Drake, Brian K. Link, Vincent Liu Tags: Case Report Source Type: research

miR‐155 is involved in tumor progression of mycosis fungoides
This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)
Source: Experimental Dermatology - May 1, 2013 Category: Dermatology Authors: L. Moyal, A. Barzilai, .B. Gorovitz, A. Hirshberg, N. Amariglio, J. Jacob‐Hirsch, L. Maron, M. Feinmesser, E. Hodak Tags: Letter to the Editor Source Type: research

How Big Is Your Hand And Should You Use It To Skin Score ?
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - April 29, 2013 Category: Dermatology Authors: J.J. Scarisbrick, S. Morris Tags: Original Article Source Type: research

Reflectance confocal microscopy for the characterization of mycosis fungoides and correlation with histology: a pilot study
ConclusionThe utility of RCM as a diagnostic tool for MF awaits further evaluation, although it appears to be promising for biopsy site selection. (Source: Skin Research and Technology)
Source: Skin Research and Technology - April 22, 2013 Category: Dermatology Authors: Wei Li, Hui Dai, Zhao Li, Ai‐E Xu Tags: Original Article Source Type: research

Mycosis Fungoides: The Addition of Concurrent and Adjuvant Interferon to Total Skin Electron Beam Therapy
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - April 21, 2013 Category: Dermatology Authors: A.E. Wagner, D. Wada, G. Bowen, D.K. Gaffney Tags: Original Article Source Type: research

Alopecia mucinosa responding to antileprosy treatment: Are we missing something?
Rajiv Joshi, Vinay GopalaniIndian Journal of Dermatology 2013 58(3):227-231Three cases with single lesion of Alopecia mucinosa (follicular mucinosis) were treated with antileprosy treatment and showed rapid and complete resolution of the lesions with no recurrence on extended follow-up. Two children, a boy aged 14 years and a girl aged 12 years presented themselves, each, with a single hypopigmented, hypoesthetic patch on the face. Clinically leprosy was suspected, however, skin biopsy from both patients revealed follicular mucinosis as the only pathological finding, without any granulomas. Based on clinical suspicion both...
Source: Indian Journal of Dermatology - April 20, 2013 Category: Dermatology Authors: Rajiv JoshiVinay Gopalani Source Type: research

Clinicopathological correlation of acquired hypopigmentary disorders
Anisha B Patel, Raj Kubba, Asha KubbaIndian Journal of Dermatology, Venereology, and Leprology 2013 79(3):376-382Acquired hypopigmentary disorders comprise a significant group of disorders that affect Indians and Asians. The pigment disturbance in darker skin individuals can be very distressing to the patient and the family. These disorders cover a wide array of pathologies including infections, autoimmune processes, lymphoproliferative disorders, and sclerosing diseases. Histological diagnosis is particularly important because treatments for these diseases are varied and specific. This review will focus on histopathologic...
Source: Indian Journal of Dermatology, Venereology and Leprology - April 19, 2013 Category: Dermatology Authors: Anisha B PatelRaj KubbaAsha Kubba Source Type: research

Pentostatin plus cyclophosphamide and bexarotene is an effective and safe combination in patients with mycosis fungoides/sezary syndrome
(Source: British Journal of Haematology)
Source: British Journal of Haematology - April 13, 2013 Category: Hematology Authors: Cristina Calderon Cabrera, Fatima de la Cruz Vicente, Ana Marín‐Niebla, Estrella Carrillo Cruz, Eduardo Rios Herranz, Ildefonso Espigado Tocino, Concepción Prats Martín, Jose F. Falantes, María L. Martino Galiana, Jose A. Perez‐Simón Tags: Correspondence Source Type: research

Papular Mycosis Fungoides: Report of Two Patients with Literature Review and Conceptual Re‐
Recent reports of ten patients have proposed a papular variant of mycosis fungoides, characterized by the appearance of papules in the absence of patches and the presence of histopathologic features of classic patch/plaque stage mycosis fungoides. Given the overlapping clinical and pathologic features between this proposed entity and lymphomatoid papulosis (LyP) type B, however, the optimal classification for such cases remains somewhat unclear. Herein two patients are described who presented to the dermatology clinic with persistent erythematous papular eruptions on the trunk, upper and lower extremities and histopatholog...
Source: Journal of Cutaneous Pathology - April 11, 2013 Category: Pathology Authors: Megan H. Noe, Ashley Drake, Brian K. Link, Vincent Liu Tags: Case Report Source Type: research

Mycosis fungoides: report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop.
This report summarizes the approach recommended for making a confident diagnosis of MF and its clinically significant variants; emphasizes pitfalls in evaluating early MF, assessing nodal involvement, and diagnosing transformed MF; and discusses the relationship between MF and primary cutaneous CD30+ T-cell lymphoproliferative disorders. Last, Sézary syndrome is discussed, with concentration on those features distinct from MF. PMID: 23525617 [PubMed - indexed for MEDLINE] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 1, 2013 Category: Pathology Authors: Song SX, Willemze R, Swerdlow SH, Kinney MC, Said JW Tags: Am J Clin Pathol Source Type: research

Non-mycosis fungoides cutaneous T-cell lymphomas: report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop.
In this report, novel findings, areas of special interest, and diagnostic challenges emerging from the cases submitted to the workshop will be highlighted. The necessity to integrate histologic, immunophenotypical, genetic, and in particular, clinical data to arrive at the correct diagnosis, and subsequently provide adequate treatment, is emphasized. PMID: 23525618 [PubMed - indexed for MEDLINE] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 1, 2013 Category: Pathology Authors: Quintanilla-Martinez L, Jansen PM, Kinney MC, Swerdlow SH, Willemze R Tags: Am J Clin Pathol Source Type: research

Epidermotropic marginal zone lymphoma simulating mycosis fungoides†
We report a case of an 80‐year‐old man who presented with asymptomatic golden brown patches and diffuse pink papules on his trunk, buttocks and hips. Biopsies revealed a lichenoid infiltrate and areas of epidermotropism. Although the overall architectural pattern was compatible with mycosis fungoides, the lymphocytes had a more monocytoid and plasmacytoid appearance, and there were interspersed mature plasma cells. Immunohistological studies revealed that the pleomorphic lymphocytes were predominantly B cells (CD20\+ and CD79a\+) with a subpopulation of smaller bland T cells (CD3\+). Moreover, the B‐cell immunophenot...
Source: Journal of Cutaneous Pathology - March 27, 2013 Category: Pathology Authors: Bonnie A. Lee, Mark Jacobson, Gregory Seidel Tags: Case Report Source Type: research

Mycosis fungoides with reactive lymphoid follicles may represent an early histopathologic picture of granulomatous slack skin
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - March 25, 2013 Category: Pathology Authors: Gerardo Ferrara, Catherine M. Stefanato Tags: Letter to the Editor Source Type: research

Pediatric Primary Follicular Mucinosis: Further Evidence of its Relationship with Mycosis Fungoides
Abstract Follicular mucinosis (FM) is an uncommon reaction pattern in which the accumulation of mucin in the follicular epithelium is the main pathologic finding. FM may be idiopathic (primary follicular mucinosis [PFM]), in association with mycosis fungoides or cutaneous T‐cell lymphoma, or in association with other neoplastic and inflammatory conditions. Herein we report a case of PFM with identical T‐cell clone rearrangement at anatomically distinct sites, supporting the idea that some authors have proposed, that FM may represent a low‐grade lymphoproliferative disease related to mycoses fungoides with favorable p...
Source: Pediatric Dermatology - March 14, 2013 Category: Dermatology Authors: Angel Santos‐Briz, Javier Cañueto, Jesus García‐Dorado, M. Teresa Alonso, Ana Balanzategui, Marcos González‐Díaz Tags: Brief Report Source Type: research

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion.
We report here a rapidly progressive case of mycosis fungoides with peculiar clinical and histological features, presenting as a haematoma-like mass on the thigh accompanied by multiple reddish brown erythematous lesions on the trunk and extremities. Histopathologically, the erythematous lesions showed epidermotropism of atypical T lymphocytes expressing CD4 and prominent syringotropism without syringometaplasia. The haematoma-like lesion consisted of diffuse and dense infiltrates of medium-to-large-sized pleomorphic lymphocytic cells expressing CD30, suggesting that CD30+ large-cell transformation had occurred. Mycosis fu...
Source: Acta Dermato-Venereologica - March 14, 2013 Category: Dermatology Authors: Hattori T, Uchiyama A, Tago O, Nagai Y, Ishikawa O Tags: Acta Derm Venereol Source Type: research

Clinical and histopathological differential diagnosis of eosinophilic pustular folliculitis
Abstract Eosinophilic pustular folliculitis (EPF) is an inflammatory disease characterized by repeated pruritic follicular papules and pustules arranged in arcuate plaques, and folliculotropic infiltration of eosinophils. The diagnosis of EPF is occasionally difficult and problematic because EPF may share the clinical appearance and histological findings with other diseases. Moreover, EPF has several clinical subtypes, including the classical type, infantile type and immunosuppression‐associated type. Because the therapies of EPF are relatively specific as compared to eczematous disorders, accurate diagnosis is essential...
Source: The Journal of Dermatology - March 12, 2013 Category: Dermatology Authors: Toshiharu Fujiyama, Yoshiki Tokura Tags: Review Article Source Type: research

Positron emission tomography for staging and response assessment of mycosis fungoides in a child
Indranil Ghosh, M Ramam, Somesh Gupta, Manoj K Singh, Pramod K Julka, Punit Sharma, Sameer BakhshiIndian Journal of Dermatology 2013 58(2):147-148 (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - March 5, 2013 Category: Dermatology Authors: Indranil GhoshM RamamSomesh GuptaManoj K SinghPramod K JulkaPunit SharmaSameer Bakhshi Source Type: research

CD30+ large cell transformation of mycosis fungoides during pregnancy
Farahnaz Fatemi Naeini, Jamshid Najafian, Mohammadali NilforoushzadehIndian Journal of Dermatology 2013 58(2):160-160Mycosis fungoides (MF) a cutaneous T-cell lymphoma, is a subgroup of non-Hodgkin's lymphomas, characterized by skin infiltration and occasionally systemic involvement. MF coincidence with pregnancy is rare. The effect of pregnancy on MF and the effect of this disease on pregnancy are still unknown. There are few case reports about pregnancy and its deleterious effect on the clinical course of MF. This case report is about a 30-years-old female with MF who became pregnant and after delivery developed C...
Source: Indian Journal of Dermatology - March 5, 2013 Category: Dermatology Authors: Farahnaz Fatemi NaeiniJamshid NajafianMohammadali Nilforoushzadeh Source Type: research

Hypopigmented mycosis fungoides in a Chinese woman
Jiang-An Zhang, Jian-Bin YuIndian Journal of Dermatology 2013 58(2):161-161 (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - March 5, 2013 Category: Dermatology Authors: Jiang-An ZhangJian-Bin Yu Source Type: research

Low-dose high-dose-rate brachytherapy in the treatment of facial lesions of cutaneous T-cell lymphoma
Conclusion: Low-dose high-dose-rate brachytherapy using custom-made surface molds is a highly efficacious therapy in the treatment of facial lesions in MF. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - February 28, 2013 Category: Dermatology Authors: Jennifer A. DeSimone, Emmanuella Guenova, Joi B. Carter, Keri S. Chaney, Julie R. Aldridge, Claire M. Noell, Andrew A. Dorosario, Jorgen L. Hansen, Thomas S. Kupper, Phillip M. Devlin Tags: Original Articles Source Type: research

Epidermotropic marginal zone lymphoma simulating mycosis fungoides
We report a case of an 80‐year‐old man who presented with asymptomatic golden brown patches and diffuse pink papules on his trunk, buttocks, and hips. Biopsies revealed a lichenoid infiltrate and areas of epidermotropism. Although the overall architectural pattern was compatible with mycosis fungoides, the lymphocytes had a more monocytoid and plasmacytoid appearance, and there were interspersed mature plasma cells. Immunohistological studies revealed that the pleomorphic lymphocytes were predominantly B‐cells (CD20+, CD79a+) with a subpopulation of smaller bland T‐cells (CD3+). Moreover, the B‐cell immunophenoty...
Source: Journal of Cutaneous Pathology - February 21, 2013 Category: Pathology Authors: Bonnie A. Lee, Mark Jacobson, Gregory Seidel Tags: Case Report Source Type: research

Mycosis Fungoides and Sézary Syndrome
The development of array comparative genomic hybridization (aCGH) techniques has allowed to characterize more precisely several human neoplasms with the aim of providing prognostic markers and targets for directed therapeutic intervention. Recently, several studies applying aCGH technique have been reported in which an exhaustive genetic characterization of mycosis fungoides (MF) and Sézary syndrome (SS) has been performed. Regarding MF, a genomic profile characterized by the gains of 7q, 17q, and 8q and losses in 9p, 13q, 17p, and 10q has been described. In SS, the most common abnormalities are gains in 8q and 17q ...
Source: Springer protocols feed by Genetics/Genomics - February 15, 2013 Category: Genetics & Stem Cells Source Type: news

Array-CGH Analysis of Cutaneous Anaplastic Large Cell Lymphoma
This chapter describes a study in which the pattern of numerical chromosomal alterations in cutaneous anaplastic large cell lymphoma (C-ALCL) tumor samples was defined using array-based comparative genomic hybridization (CGH). First, the array-based CGH technique applied is outlined in detail. Next, its application in the analysis of C-ALCL tumor specimens is described. This approach resulted in the identification of highly recurrent chromosomal alterations in C-ALCL that include gain of 7q31 and loss on 6q16-6q21 and 13q34, each affecting 45% of the patients. The pattern characteristic of C-ALCL differs markedly from chro...
Source: Springer protocols feed by Genetics/Genomics - February 15, 2013 Category: Genetics & Stem Cells Source Type: news

Improvement in peripheral blood disease burden in patients with Sézary syndrome and leukemic mycosis fungoides after total skin electron beam therapy
Conclusion: In patients with advanced mycosis fungoides and Sézary syndrome, the peripheral blood tumor burden may improve after treatment with TSEB. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - February 14, 2013 Category: Dermatology Authors: Rachel S. Klein, James D. Dunlop, Sara S. Samimi, Kelly A. Morrissey, Katherine G. Evans, Jennifer M. Gardner, Camille E. Introcaso, Carmela C. Vittorio, Alain H. Rook, Bizhan Micaily, Ellen J. Kim Tags: Original Articles Source Type: research

Surface Mold Brachytherapy for Mycosis Fungoides of the Foot
The purpose of our innovation was to develop a method of conformal irradiation to the skin of the ankle and foot which, in the past, has proven challenging to treat with external beam radiotherapy. (Source: Journal of Medical Imaging and Radiation Sciences)
Source: Journal of Medical Imaging and Radiation Sciences - February 11, 2013 Category: Radiology Authors: M. Westerland, C. Jenkins, J. Gooding, C. Gaddess, L. Tomasich, M. Freedman, J. Rose Tags: Abstracts Source Type: research

Latitude gradients for lymphoid neoplasm subtypes in australia support an association with ultraviolet radiation exposure
ABSTRACT Given the uncertainty surrounding solar ultraviolet radiation (UVR) exposure and risk of lymphoid neoplasms, we performed an ecological analysis of national Australian data for incident cases diagnosed between 2002‐2006. Subtype‐specific incidence was examined by latitude band (<29°S, 29‐36°S, ≥37°S), a proxy for ambient UVR exposure, using multiple Poisson regression, adjusted for sex, age‐group and calendar year. Incidence increased with distance from the equator for several mature B‐cell non‐Hodgkin lymphomas, including diffuse large B‐cell (incidence rate ratio [IRR] = 1.37; 95%CI 1.16–...
Source: International Journal of Cancer - February 5, 2013 Category: Cancer & Oncology Authors: Marina T. van Leeuwen, Jennifer J. Turner, Michael O. Falster, Nicola S. Meagher, David J. Joske, Andrew E. Grulich, Graham G. Giles, Claire M. Vajdic Tags: Epidemiology Source Type: research

Hypopigmented mycosis fungoides in Egyptian patients
We described the clinical characteristics, pathological features, immunohistochemical profile and prognosis of HMF in Egyptian patients. During the period from January 2004 to December 2011, we were able to diagnose and follow up 27 patients with HMF. The study included 18 males (66.7%) and 9 females (33.3%) with a mean age of 35.39 ±13.13 years. The duration ranged from 1 to 6 years with a mean of 3.26 ±1.7 years. The majority of patients were skin type IV (63%) and presented with multiple (88.9%), asymptomatic (74.1%), ill‐defined (70.4%) and non‐scaly (77.8%) lesions distributed on the trunk (81.5%). Histolo...
Source: Journal of Cutaneous Pathology - February 5, 2013 Category: Pathology Authors: Hussein M. M. Hassab‐El‐Naby, Mohamed A. El‐Khalawany Tags: Original Article Source Type: research

A case of IgA nephropathy associated with mycosis fungoides that developed into rapidly progressive glomerulonephritis.
Abstract A 53-year-old Japanese malewas diagnosed with atopic dermatitis and initiatedtreatment with a local dermatologist inFebruary 2001. A routine medical check-uprevealed proteinuria, microscopic hematuriaand slight elevation of serum creatinine levelin spring 2006. He was referred to our hospitalfor nephrology consultation and followup.In December 2009, he developed a suddenhigh fever of greater than 39 °C with sorethroat. In addition, his serum creatinine levelgreatly increased to 4.6 mg/dl. His prevalentrenal illness was thought to be rapidly progressiveglomerulonephritis (RPGN). Soonafter admission, kidney...
Source: Clinical Nephrology - February 1, 2013 Category: Urology & Nephrology Authors: Hara M, Nemoto T, Hijima T, Tsuchiya K, Nitta K, Ando M Tags: Clin Nephrol Source Type: research

Follicular lymphomatoid papulosis revisited: A study of 11 cases, with new histopathological findings
Conclusions: Follicular LyP is a variant of LyP with involvement of hair follicles, mostly in the form of perifollicular infiltrate with variable degree of folliculotropism. Other changes including hyperplasia of the follicular epithelium, rupture of hair follicle, and follicular mucinosis are less common. Rarely, intrafollicular pustules can be seen in the follicular epithelium; such lesions manifest clinically as pustules. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - February 1, 2013 Category: Dermatology Authors: Werner Kempf, Dmitry V. Kazakov, Hans-Peter Baumgartner, Heinz Kutzner Tags: Dermatopathology Source Type: research

Racial differences in mycosis fungoides: A retrospective study with a focus on eosinophilia
Background: Mycosis fungoides (MF) is often associated with eosinophilia and portends a poorer prognosis. MF is more common in blacks and follows a more aggressive course compared with whites.Objective: We further elucidate racial differences between blacks and whites with MF, focusing on blood eosinophilia.Methods: The records of 345 patients with MF were reviewed for demographic, clinical, and pathologic data and evaluated by analysis of variance.Results: The average age at diagnosis for blacks was 45 years and was 55 years for white patients (P (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 31, 2013 Category: Dermatology Authors: John G. Zampella, Ginette A. Hinds Tags: Original Articles Source Type: research

Papular Mycosis Fungoides on the Legs: A Case Report.
PMID: 23339994 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - January 19, 2013 Category: Dermatology Authors: Santamarina-Albertos A, Muñoz-Martínez R, Alvarez-Gago T, Miranda-Romero A Tags: Actas Dermosifiliogr Source Type: research

Photodynamic Therapy in Mycosis Fungoides.
This article reviews the literature and the practical application of photodynamic therapy in mycosis fungoides. PMID: 23332865 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - January 17, 2013 Category: Dermatology Authors: Fernández-Guarino M, Jaén-Olasolo P Tags: Actas Dermosifiliogr Source Type: research

Hypopigmented mycosis fungoides in Egyptian patients
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - January 16, 2013 Category: Pathology Authors: Hussein M. M Hassab‐El‐Naby, Mohamed A. El‐Khalawany Tags: Original Article Source Type: research

Composite lymphoma of mycosis fungoides and cutaneous small B-cell lymphoma in a 73-year-old male patient
Summary: Composite lymphoma of T-cell and B-cell type is uncommon, and the one occurring primarily on skin is extremely rare. Herein, we report a unique case of composite lymphoma of mycosis fungoides and cutaneous small B-cell lymphoma in a 73-year-old male patient. The patient presented with multiple erythematous patches, plaques, and nodules on the upper arms, scalp, and trunk. Four punch biopsies of arm and scalp lesions demonstrated lymphoid infiltrate in superficial to deep dermis with a characteristic zone distribution of T-cell and B-cell components. T cells were distributed in papillary and perifollicular dermis a...
Source: Human Pathology - January 14, 2013 Category: Pathology Authors: Nicholas A. Whitling, Rebecca P. Shanesmith, Leah Jacob, Elizabeth McBurney, Siby Sebastian, Endi Wang, Alun R. Wang Tags: Case Studies Source Type: research

New Insights into Associated Co-morbidities in Patients with Cutaneous T-cell Lymphoma (Mycosis Fungoides).
This study investigated the association between MF and malignancies, anxiety and depression in the Israeli population. Data on Israeli patients with MF and age- and gender-matched controls were collected from a database of population- based cohort (683 patients; 1,700 controls) and an institution- based cohort (343 patients; 846 controls) and analysed by univariate and multivariate methods. MF was significantly associated with Hodgkin's lymphoma in both cohorts (multivariate odds ratio (OR) 7.83, univariate OR ∞, respectively); acute leukaemia (multivariate OR 10.1, first cohort) and lung cancer (multivariate OR 10.15, s...
Source: Acta Dermato-Venereologica - January 10, 2013 Category: Dermatology Authors: Hodak E, Lessin S, Friedland R, Freud T, David M, Pavlovsky L, Shapiro J, Cohen AD Tags: Acta Derm Venereol Source Type: research

Classification of Mycosis Fungoides and Sezary SyndromeClassification of Mycosis Fungoides and Sezary Syndrome
This article focuses on the evaluation and classification of mycosis fungoides and Sezary syndrome, two of the most common forms of cutaneous t-cell lymphoma. What treatment options are available? Skin Therapy Letter (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 3, 2013 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

The antihistamines clemastine and desloratadine inhibit STAT3 and c‐Myc activities and induce apoptosis in cutaneous T‐cell lymphoma cell lines
Abstract Mycosis fungoides and its leukemic counterpart Sézary syndrome are the most frequent cutaneous T‐cell lymphomas (CTCL), and there is no cure for these diseases. We evaluated the effect of clinically approved antihistamines on the growth of CTCL cell lines. CTCL cell lines as wells as blood lymphocytes from patients with Sézary syndrome were cultured with antihistamines and the cell were analysed for proliferation, apoptosis and expression of programmed death molecules and transcription factors. The two antihistamines clemastine and desloratadine, currently used for symptom alleviation in allergy, induced poten...
Source: Experimental Dermatology - January 1, 2013 Category: Dermatology Authors: Udo Döbbeling, Ying Waeckerle‐Men, Franziska Zabel, Nicole Graf, Thomas M. Kündig, Pål Johansen Tags: Regular Article Source Type: research

Pharmacokinetic and pharmacodynamic characterization of a new formulation containing synergistic proportions of interferons alpha-2b and gamma (HeberPAG(R)) in patients with mycosis fungoides: an open-label trial
Conclusions: HeberPAG(R) possesses improved pharmacodynamic properties that may be very useful in the oncologic setting. Efficacy trials can be carried out to confirm these findings.Trial registration: Registro Publico Cubano de Ensayos Clinicos RPCEC00000130. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 28, 2012 Category: Drugs & Pharmacology Authors: Yanelda García-VegaIdrian García-GarcíaSonia Collazo-CaballeroEgla Santely-PraviaAlieski Cruz-RamírezÁngela Tuero-IglesiasCristian Alfonso-AlvaradoMileidys Cabrera-PlaceresNailet Castro-BasartYaquelín Duncan-RobertsTania Carballo-TretoJosanne Soto-M Source Type: research

Pediatric Follicular Mucinosis: Presentation, Histopathology, Molecular Genetics, Treatment, and Outcomes over an 11‐Year Period at the Mayo Clinic
Abstract Follicular mucinosis (FM) and folliculotropic mycosis fungoides (MF) are rare in children, and data regarding long‐term outcomes are limited. We sought to describe clinical and histopathologic findings of children with FM with and without MF, as well as treatments administered and clinical outcomes. We conducted a retrospective chart review of patients younger than 22 years (at time of diagnosis) with a biopsy demonstrating FM who were seen in the Dermatology Department at the Mayo Clinic from September 1, 1999, to September 1, 2010. Eleven patients (six male, five female) ages 11 to 19 years at the time of diag...
Source: Pediatric Dermatology - December 28, 2012 Category: Dermatology Authors: Ali Alikhan, John Griffin, Nicholas Nguyen, Dawn Marie R. Davis, Lawrence E. Gibson Tags: Clinical and Laboratory Investigation Source Type: research

TOX is a specific marker for cutaneous T cell lymphomas
In this study, we evaluated TOX expression in biopsy specimens from various types of cutaneous lymphoma. The followings were enrolled; MF (2 patch, 2 plaque, and 2 tumor samples), SS (2 samples), anaplastic large cell lymphoma (ALCL; 5 samples), adult T cell lymphoma (ATL; 5 samples), diffuse large B dell lymphoma (DLBCL; 5 samples), lymphomatoid papulosis (Lyp; 5 samples), and peripheral T cell lymphoma not otherwise specified (PTL, NOS; 5 samples). We also evaluated TOX expression using skin specimen from healthy controls (5 samples) and AD (2 samples). Dermal atypical lymphocytes showed a high specific nuclear staining ...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Sohshi Morimura, Makoto Sugaya, Hiraku Suga, Tomomitsu Miyagaki, Hanako Ohmatsu, Hideki Fujita, Yoshihide Asano, Yayoi Tada, Takafumi Kadono, Shinichi Sato Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Poikilodermatous mycosis fungoides with a CD8+ CD56+ immunophenotype: a case report and literature review
Mycosis fungoides (MF) represents the most common type of cutaneous lymphoma. MF shows varieties in both its clinical presentation and immunophenotype. We herein report one case of poikilodermatous MF with a CD8+ CD56+ immunophenotype and present a literature review. A 20‐year‐old Japanese woman presented with a 10‐year history of multiple poikilodermatous and reddish or brownish patches with mild pruritus on the chest, abdomen, back, buttock and thighs. Histopathologically, small‐ to medium‐sized atypical lymphocytes infiltrated into the epidermis, indicating epidermotropism, along the basal layer, and distribut...
Source: Journal of Cutaneous Pathology - December 14, 2012 Category: Pathology Authors: Tatsushi Shiomi, Yasumasa Monobe, Chiaki Kuwabara, Haruko Hayashi, Takenobu Yamamoto, Yoshito Sadahira Tags: Case Report Source Type: research

Romidepsin and interferon gamma: A novel combination for refractory cutaneous T-cell lymphoma
To the Editor: A 62-year-old man presented to our clinic with a history of red pruritic nodules and was diagnosed with mycosis fungoides/cutaneous T-cell lymphoma (CTCL), stage IIB (T3 N2 M0 B1). Combination therapy was initiated with oral bexarotene, interferon alfa-2b, and extracorporeal photopheresis. Four months later, total skin electron beam therapy and interferon gamma were added and resulted in a complete response in the skin, but within 2 months, he developed widespread recurrent skin nodules (). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - December 13, 2012 Category: Dermatology Authors: Sara Samimi, Kelly Morrissey, Sasha Anshelevich, Katherine Evans, Jennifer Gardner, Amy Musiek, Carmela Vittorio, Alain Rook, Ellen Kim Tags: JAAD Online Source Type: research