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This page shows you the latest news and research items in this category.

Resistant hypercalcaemia in metastatic parathyroid carcinoma.
PMID: 23725272 [PubMed - in process] (Source: Med J Aust)
Source: Med J Aust - June 8, 2013 Category: Journals (General) Authors: Bowyer SE, White AM, Ransom DT, Davidson JA Tags: Med J Aust Source Type: research

Complete Genomic Landscape of a Recurring Sporadic Parathyroid Carcinoma
Abstract Parathyroid carcinoma is a rare endocrine malignancy with an estimated incidence of less than 1 per million population. Excessive secretion of parathyroid hormone, extremely high serum calcium level and the deleterious effects of hypercalcemia are the clinical manifestations of the disease. Up to 60% of patients develop multiple disease recurrences and although long‐term survival is possible with palliative surgery, permanent remission is rarely achieved. Molecular drivers of sporadic parathyroid carcinoma have remained largely unknown. Previous studies, mostly based on familial cases of the disease, suggested p...
Source: The Journal of Pathology - April 24, 2013 Category: Pathology Authors: Katayoon Kasaian, Sam M Wiseman, Nina Thiessen, Karen L Mungall, Richard D Corbett, Jenny Q Qian, Ka Ming Nip, Ann He, Kane Tse, Eric Chuah, Richard J Varhol, Pawan Pandoh, Helen McDonald, Thomas Zeng, Angela Tam, Jacquie Schein, Inanc Birol, Andrew J Mun Tags: Original Article Source Type: research

Parathyroid carcinoma in a 30-year-old man: a diagnostic and management challenge
In this report, we aim to present the challenges in managing parathyroid carcinoma and discuss factors that might contribute to future locoregional recurrences. This case also highlighted several issues, including the challenge of ascertaining the diagnosis before surgery and the dilemma of reoperation after simple excision. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - April 8, 2013 Category: Cancer & Oncology Authors: Sze-How NgBrian Lang Source Type: research

Nonfunctional Parathyroid Carcinoma After Breast Carcinoma [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - March 15, 2013 Category: Cancer & Oncology Authors: Guo, Mai, Liu, Peng, Yang, Wu, Zhang Tags: Diagnosis & Staging DIAGNOSIS IN ONCOLOGY Source Type: research

Parathyroid carcinoma and hungry bone syndrome
In this study, HBS was observed in both patients, who presented severe bone disease prior to surgery. HBS would be expected post-operatively in successful parathyroid carcinoma removal.O presente artigo descreve o relato de dois pacientes com carcinoma de paratiroide que apresentavam valores intensamente elevados de cálcio sérico e de PTH, associado a doença óssea e presença de nódulo cervical palpável ao diagnóstico. Ambos foram submetidos à paratiroidectomia, sendo que um evoluiu com metástases pulmonares. Hipocalcemia importante foi observada após a paratiroidectomia em um paciente e somente após remoção c...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - February 26, 2013 Category: Endocrinology Source Type: research

Parathyroid carcinoma initiated by hypercalcemic crisis.
PMID: 23422208 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - February 1, 2013 Category: Journals (General) Authors: Liu JP, Wang XL, Shi J, Dou JT, Ba JM, Lü ZH, Yang LJ, Liu JM, Li CL, Mu YM Tags: Chin Med J (Engl) Source Type: research

The Changing Clinical Patterns of Primary Hyperparathyroidism in Chinese Patients: Data from 2000 to 2010 in a Single Clinical Center.
Conclusions:The overall clinical and biochemical features of PHPT in Chinese patients are still classic, but the disease is now evolving into a more asymptomatic type. The incidental parathyroid lesion captured by routine neck ultrasonography was the leading cause for such a dramatic change. The high incidence of parathyroid carcinoma is now decreasing. PMID: 23365127 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 30, 2013 Category: Endocrinology Authors: Zhao L, Liu JM, He XY, Zhao HY, Sun LH, Tao B, Zhang MJ, Chen X, Wang WQ, Ning G Tags: J Clin Endocrinol Metab Source Type: research

Frequent Large Germline HRPT2 Deletions in a French National Cohort of Patients With Primary Hyperparathyroidism.
Conclusion:Gross deletion analysis of the HRPT2 gene is indicated for all patients negative for mutation, presenting with HPT-JT or familial isolated hyperparathyroidism, parathyroid carcinoma, or in patients with apparently sporadic parathyroid adenoma diagnosed at a young age, having a severe hypercalcemia. PMID: 23293331 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 4, 2013 Category: Endocrinology Authors: Bricaire L, Odou MF, Cardot-Bauters C, Delemer B, North MO, Salenave S, Vezzosi D, Kuhn JM, Murat A, Caron P, Sadoul JL, Silve C, Chanson P, Barlier A, Clauser E, Porchet N, Groussin L, the GTE Group Tags: J Clin Endocrinol Metab Source Type: research

Calcimimetic and calcilytic drugs
Abstract: Drugs acting on the calcium receptor (CaR) can rapidly alter circulating levels of parathyroid hormone (PTH) and are therefore useful in the treatment of disorders of mineral metabolism. The type II calcimimetic cinacalcet is approved for treating secondary hyperparathyroidism (HPT) in patients receiving renal replacement therapy or in those with parathyroid carcinoma and is gaining approval for treating primary HPT in a number of EU countries. The type I calcimimetic KAI-4169 is currently in late stage clinical development for treating secondary HPT in patients with chronic kidney disease, so this agonist of the...
Source: Bone - October 8, 2012 Category: Orthopaedics Authors: E.F. Nemeth Tags: Oral Presentations Source Type: research

Parathyroid Carcinoma: Challenges in Diagnosis and Treatment
Parathyroid carcinoma is a malignant neoplasm affecting 0.5% to 5.0% of all patients with primary hyperparathyroidism. Since it was first described by De Quervain in 1904 to this day, it continues to defy diagnosis and treatment because of its rarity, overlapping features with benign parathyroid disease, and lack of distinct characteristics. En bloc surgical extirpation of the tumor with clear margins remains the best curative treatment. Although prolonged survival is possible with recurrent or metastatic disease, cure is rarely achievable. Efficacy of adjuvant therapies, such as radiotherapy and chemotherapy, in managemen...
Source: Hematology/Oncology Clinics of North America - October 8, 2012 Category: Cancer & Oncology Authors: Arash Mohebati, Ashok Shaha, Jatin Shah Source Type: research

Biomarkers of Parathyroid Carcinoma
Abstract The diagnosis of parathyroid carcinoma can be challenging, and adjuvant therapies such as radiotherapy and chemotherapy are not particularly beneficial in the management of this disease, creating a challenge when dealing with unresectable recurrent and metastatic malignancy. We investigated the expression profile of biomarkers that represent potential markers of malignancy or targets for novel therapies in this disease. We constructed a tissue microarray of parathyroid carcinomas from 10 patients as well as parathyroid adenomas from 25 patients and stained the slides for 34 proteins involved in angi...
Source: Endocrine Pathology - September 22, 2012 Category: Pathology Tags: Endocrine Pathology Source Type: research

Concurrent parathyroid carcinoma and hyperplasia in hyperparathyroidism.
PMID: 23019404 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - September 1, 2012 Category: Internal Medicine Authors: Oh MY, Oh SB, Seoung HG, Kim JH, Kim SS, Kim BH, Kim IJ Tags: Korean J Intern Med Source Type: research

Mediastinal parathyroid carcinoma: a case report.
Abstract A 72 year-old woman with primary hyperparathyroidism was operated for parathyroid crisis. PTH serum level was 808 pg/mL. During the operation, only two superior parathyroid glands were found. One was normal, and hypertrophy was revealed in the other. After the surgical procedure, PTH serum level was 726.5 pg/mL. Helical computer tomography examination showed a heterogeneous mass in the anterior mediastinum. The tumour was removed via a sternotomy approach. Histopathological examination revealed parathyroid carcinoma. PTH level dropped to 5.74 pg/mL. Cytofluorometric examination revealed diploidy (DI = 1) i...
Source: Endokrynologia Polska - August 7, 2012 Category: Endocrinology Authors: Gawrychowski J, Gabriel A, Kluczewska E, Buła G, Lackowska B Tags: Endokrynol Pol Source Type: research

Preoperative predictive factors for parathyroid carcinoma in patients with primary hyperparathyroidism.
In conclusion, elevated serum ALP and a large parathyroid mass at the time of diagnosis can be helpful to predict PC in patients with PHPT. PMID: 22876055 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - August 1, 2012 Category: Journals (General) Authors: Bae JH, Choi HJ, Lee Y, Moon MK, Park YJ, Shin CS, Park do J, Jang HC, Kim SY, Kim SW Tags: J Korean Med Sci Source Type: research

A case report: Giant cystic parathyroid adenoma presenting with parathyroid crisis after Vitamin D replacement
Conclusion: This case of parathyroid crisis, with very high serum calcium and parathyroid hormone levels, is a rare presentation of parathyroid adenoma with cystic degeneration. This case also highlights that Vitamin D replacement may unmask subclinical hyperparathyroidism. Consistent hypokalemia until surgery merits research into its association with hypercalcemia. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - July 28, 2012 Category: Endocrinology Authors: Ali AsgharMubasher IkramNajmul Islam Source Type: research

Can SPECT change the surgical strategy in patients with primary hyperparathyroidism?
We describe the case of a 50-year-old female patient diagnosed with PHPT, who underwent a surgical procedure without success, with maintenance of hypercalcemia and hyperparathyroidism. In this case, the hyperfunctioning parathyroid was located in the retrotracheal region only after scintigraphy combined with SPECT/CT were used.O hiperparatireoidismo primário (HPTP) é a causa mais comum de hipercalcemia diagnosticada ambulatorialmente. É mais frequente no sexo feminino e na pós-menopausa e a prevalência é de 1 a 4:1000 na população geral. O adenoma solitário esporádico secretor de PTH corresponde a 90% dos casos d...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - July 14, 2012 Category: Endocrinology Source Type: research

Development of a Formula to Predict Parathyroid Carcinoma in Patients with Primary Hyperparathyroidism
Conclusions The new logarithmic formula can be used to calculate the individual risk for PC. If the calculated individual risk exceeds 5 %, en bloc resection seems to be justified to provide long-term cure in case of PC. Content Type Journal ArticlePages 1-7DOI 10.1007/s00268-012-1707-9Authors Elias Karakas, Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Baldingerstraße, 35043 Marburg, GermanyHans-Helge Müller, Institute of Medical Informatics, Biometry and Epidemiology, University of Munich, Munich, GermanyVladimir K. Lyadov, Department of Surgery, Medical...
Source: World Journal of Surgery - July 10, 2012 Category: Surgery Tags: World Journal of Surgery Source Type: research

Molecular profiling of parathyroid hyperplasia, adenoma and carcinoma.
This study was based on surgically removed parathyroid tissues, gene expression analysis was performed both at gene and protein level. First, mRNA isolation was performed from deep-frozen tissue samples, and further apoptosis pathway-specific cDNA macroarray analysis was carried out. The results were validated with real-time PCR. Subsequently, protein expression was analyzed with immunhistochemistry on Tissue Micro Array multi-blocks derived from several paraffin-embedded samples. cDNA macroarrays revealed elevated expression of both pro-apoptotic (FAS receptor, TRAIL ligand, CASPASE8, and -4) and anti-apoptotic (cIAP1, AP...
Source: Pathology Oncology Research - July 1, 2012 Category: Pathology Authors: Árvai K, Nagy K, Barti-Juhász H, Peták I, Krenács T, Micsik T, Végső G, Perner F, Szende B Tags: Pathol Oncol Res Source Type: research

Parathyroid carcinoma presenting as a hyperparathyroid crisis.
PMID: 22707898 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 1, 2012 Category: Internal Medicine Authors: Tan AH, Kim HK, Kim MY, Oh YL, Kim JS, Chung JH, Kim SW Tags: Korean J Intern Med Source Type: research

[Mediastinal parathyroid carcinoma: a case report.]
Abstract A 72 year-old woman with primary hyperparathyroidism was operated for parathyroid crisis. PTH serum level was 808 pg/mL. During the operation, only two superior parathyroid glands were found. One was normal, and hypertrophy was revealed in the other. After the surgical procedure, PTH serum level was 726.5 pg/mL. Helical computer tomography examination showed a heterogeneous mass in the anterior mediastinum. The tumour was removed via a sternotomy approach. Histopathological examination revealed parathyroid carcinoma. PTH level dropped to 5.74 pg/mL. Cytofluorometric examination revealed diploidy (DI = 1) i...
Source: Endokrynologia Polska - May 4, 2012 Category: Endocrinology Authors: Gawrychowski J, Gabriel A, Kluczewska E, Buła G, Lackowska B Tags: Endokrynol Pol Source Type: research

Pathology of the parathyroid glands
Abstract: Abnormalities of the parathyroid glands are the commonest cause of hypercalcaemia and the histopathologist has an important role in classifying the underlying pathological condition. Diagnostic assessment includes confirmation that the tissue removed is parathyroid versus, most commonly, lymph nodes or thyroid, possibly requiring intra-operative assessment, and in hyperparathyroidism, establishing whether excised parathyroid glands represent hyperplasia or neoplasia. The commonest neoplastic diagnosis is of an adenoma, usually single, and ‘atypical adenoma’ and carcinoma are much less common. It is important ...
Source: Diagnostic Histopathology - April 16, 2012 Category: Pathology Authors: Jon van der Walt Tags: Mini-Symposium: Endocrine Pathology Source Type: research

Classification of Parathyroid Cancer
Conclusions This study confirms the validity of both classification systems for disease outcome in patients with parathyroid cancer. Content Type Journal ArticleCategory Endocrine TumorsPages 1-9DOI 10.1245/s10434-012-2306-6Authors Klaus-Martin Schulte, Department of Endocrine Surgery, King’s College Hospital, King’s Health Partners, London, UKAnthony J. Gill, Department of Anatomical Pathology, Royal North Shore Hospital, St. Leonards, NSW, AustraliaMarcin Barczynski, Department of Endocrine Surgery, Jagiellonian University College of Medicine, Krakow, PolandElias Karakas, Department of Visceral, T...
Source: Annals of Surgical Oncology - March 20, 2012 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: research

Carcinoma of endocrine organs: Results of the RARECARE project
Abstract: The rarity or the asymptomatic character of endocrine tumours results in a lack of epidemiological studies on their incidence and survival patterns. The aim of this study was to describe the incidence, prevalence and survival of endocrine tumours using a large database, which includes cancer patients diagnosed from 1978 to 2002, registered in 89 population-based cancer registries (CRs) with follow-up until 31st December 2003. These data give an unique overview of the burden of endocrine carcinomas in Europe.A list of tumour entities based on the third International Classification of Diseases for Oncology was prov...
Source: European Journal of Cancer - February 24, 2012 Category: Cancer & Oncology Authors: Jan Maarten van der Zwan, Sandra Mallone, Boukje van Dijk, Magdalena Bielska-Lasota, Renée Otter, Roberto Foschi, Eric Baudin, Thera P. Links, The RARECARE WG Tags: Special series - rare tumours Source Type: research

Functional Parathyroid Cyst: A Rare Cause of Malignant Hypercalcemia with Primary Hyperparathyroidism—A Case Report and Review of the Literature
Parathyroid cysts are rare lesions found in the neck and anterior mediastinum. They are often nonfunctional (>90%) and rarely in the functional form. This paper discusses a case of severe hypercalcemia (23 mg/dL) secondary to a rare functional parathyroid cyst. The patient was later found to have a hemorrhagic cyst with compression of the right recurrent laryngeal nerve. Preoperative diagnosis of the lesion was parathyroid carcinoma. However, reexploration of the parathyroid mass along with microscopic study confirmed the diagnosis of a parathyroid cyst. Following cystectomy, the patient restored her baseline fu...
Source: Diagnostic and Therapeutic Endoscopy - February 15, 2012 Category: Surgery Source Type: research

Parathyroid Carcinoma: Update and Guidelines for Management
Opinion statement Parathyroid carcinoma is one of the rarest known malignancies that may occur sporadically or as a part of a genetic syndrome. It accounts for approximately 1% of patients with primary hyperparathyroidism. The majority (90%) of parathyroid cancer tumors are hormonally functional and hypersecrete parathyroid hormone (PTH). Thus, most patients exhibit strong symptomatology of hypercalcemia at presentation. Sometimes, it can be difficult to diagnose parathyroid cancer preoperatively due to clinical features shared with benign causes of hyperparathyroidism. Imaging techniques such as neck ultras...
Source: Current Treatment Options in Oncology - February 11, 2012 Category: Cancer & Oncology Tags: Current Treatment Options in Oncology Source Type: research

Parathyroid carcinoma presenting as genu valgum.
PMID: 22410521 [PubMed - in process] (Source: Indian Pediatrics)
Source: Indian Pediatrics - February 8, 2012 Category: Pediatrics Authors: Vinodh M, Rajeshwari A Tags: Indian Pediatr Source Type: research

Hyperparathyroidism–jaw tumor syndrome
ConclusionHPT‐JT is a complex syndrome with phenotypic manifestations that can seem physiologically and temporally unrelated. The risk of parathyroid carcinoma is elevated in patients with HPT‐JT, necessitating rapid treatment and complete tumor resection to reduce the morbidity and mortality associated with intractable hypercalcemia due to local recurrence or metastatic disease. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)
Source: Head and Neck - February 2, 2012 Category: ENT & OMF Authors: Matthew R. KutcherMatthew H. RigbyMartin BullockJonathan TritesS. Mark TaylorRobert D. Hart Tags: Case Report Source Type: research

Parathyroid cancer: Outcome analysis of 16 patients treated at the princess margaret hospital
ConclusionIn patients with parathyroid carcinoma, definition of prognostic factors and the role of adjuvant radiation treatment has still to be elucidated. Nevertheless, angioinvasion and positive resection margins are critical factors regarding disease‐free survival in patients with parathyroid carcinomas. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)
Source: Head and Neck - January 31, 2012 Category: ENT & OMF Authors: Boban M. Erovic, David P. Goldstein, Dae Kim, Ozgur Mete, James Brierley, Richard Tsang, Jeremy L. Freeman, Sylvia L. Asa, Lorne Rotstein, Jonathan C. Irish Tags: Original Article Source Type: research

Parathyroid carcinoma presenting as normocalcemic hyperparathyroidism
We describe the case of a 62-year-old woman with a 2-year history of asthenia and mental depression. Her past medical history was significant for osteoporosis. A diagnosis of primary normocalcemic hyperparathyroidism was established and the patient underwent surgery. PC was suspected intraoperatively because of the size and appearance of the parathyroid mass (a grayish, lobulated 3.5 cm mass). Thus, aggressive surgery (en bloc resection) was performed, along with bilateral neck exploration. Pathological examination of the specimens confirmed the suspicion of PC, demonstrating vascular invasion and extracapsular infilt...
Source: Journal of Bone and Mineral Metabolism - January 13, 2012 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: research

Carcinoma of Two Parathyroid Glands Caused by a Novel MEN1 Gene Mutation - a Rare Feature of the MEN1 Syndrome.
This report presents a clinical case of the MEN 1 syndrome: a 39-year-old woman underwent surgery for carcinoma of two parathyroid glands as well as was treated for pituitary prolactinoma, which caused infertility, and malignant insulinoma; the patient had multiple subcutaneous lipomas as well. Genetic analysis revealed a novel germline mutation in the MEN 1 gene - a nucleotide insertion at codon 43 in exon 2 (c.129insA), which caused the occurrence of the MEN 1 syndrome. The clinical case of the MEN 1 syndrome presented here is relevant in gathering the data on etiopathogenesis of not only MEN 1 syndrome, but an extremely...
Source: Medicina (Kaunas) - December 30, 2011 Category: Universities & Medical Training Authors: Juodelė L, Serapinas D, Sabaliauskas G, Krasauskienė A, Krasauskas V, Verkauskienė R, Barkauskienė D, Juozaitytė E Tags: Medicina (Kaunas) Source Type: research

Molecular Profiling of Parathyroid Hyperplasia, Adenoma and Carcinoma.
This study was based on surgically removed parathyroid tissues, gene expression analysis was performed both at gene and protein level. First, mRNA isolation was performed from deep-frozen tissue samples, and further apoptosis pathway-specific cDNA macroarray analysis was carried out. The results were validated with real-time PCR. Subsequently, protein expression was analyzed with immunhistochemistry on Tissue Micro Array multi-blocks derived from several paraffin-embedded samples. cDNA macroarrays revealed elevated expression of both pro-apoptotic (FAS receptor, TRAIL ligand, CASPASE8, and -4) and anti-apoptotic (cIAP1, AP...
Source: Pathology Oncology Research - December 24, 2011 Category: Pathology Authors: Arvai K, Nagy K, Barti-Juhász H, Peták I, Krenács T, Micsik T, Végső G, Perner F, Szende B Tags: Pathol Oncol Res Source Type: research

Hypercalcaemia due to parathyroid carcinoma presenting in the third trimester of pregnancy
We present a case of parathyroid carcinoma in pregnancy presenting with pre‐eclampsia at 32 weeks’ gestation. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)
Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology - December 20, 2011 Category: OBGYN Authors: Ryan G. Paul, Marianne S. Elston, Anthony J. Gill, Deborah Marsh, Ian Beer, Louise Wolmarans, John V. Conaglen, Goswin Y. Meyer-Rochow Tags: Short Communication Source Type: research

Outcome of 19 dogs with parathyroid carcinoma after surgical excision*
The objective of this study was to describe the outcome of dogs with PTC treated with surgical excision. Medical records of 19 dogs undergoing surgical excision of PTC between 1990 and 2010 were reviewed retrospectively. Dogs were presented for clinical hypercalcaemia or incidental hypercalcaemia noted by referring veterinarians on routine serum chemistry profiles. A parathyroid nodule was identified with cervical ultrasound in 17/17 dogs. Hypercalcaemia resolved in 18/19 dogs within 4 days postoperatively. Nine developed hypocalcaemia. None were confirmed to develop recurrent or metastatic PTC. The only death associated w...
Source: Veterinary and Comparative Oncology - December 16, 2011 Category: Veterinary Research Authors: E. S. Sawyer, N. C. Northrup, C. W. Schmiedt, W. T. N. Culp, K. M. Rassnick, L. D. Garrett, K. A. Selting, C. F. Saba, E. W. Howerth Source Type: research

Identification of the first germline HRPT2 whole‐gene deletion in a patient with primary hyperparathyroidism
Conclusions We report the first large germline deletion of the HRPT2 gene, which was not detectable by conventional PCR‐based sequencing methods. This finding emphasizes that qPCR should be implemented in HRPT2 molecular analysis, which may improve genetic assessment and clinical management of patients with FIHP and HPT‐JT. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - December 7, 2011 Category: Endocrinology Authors: Rita DominguesRute Alexandra TomazCarmo MartinsCarla NunesMaria João BugalhoBranca Maria Cavaco Tags: ORIGINAL ARTICLE Source Type: research

Hypercalcaemia due to parathyroid carcinoma presenting in the third trimester of pregnancy
We present a case of parathyroid carcinoma in pregnancy presenting with pre‐eclampsia at 32 weeks’ gestation. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)
Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology - December 1, 2011 Category: OBGYN Authors: Ryan G. PAULMarianne S. ELSTONAnthony J. GILLDeborah MARSHIan BEERLouise WOLMARANSJohn V. CONAGLENGoswin Y. MEYER‐ROCHOW Source Type: research

Outcome of 19 dogs with parathyroid carcinoma after surgical excision*
The objective of this study was to describe the outcome of dogs with PTC treated with surgical excision. Medical records of 19 dogs undergoing surgical excision of PTC between 1990 and 2010 were reviewed retrospectively. Dogs were presented for clinical hypercalcaemia or incidental hypercalcaemia noted by referring veterinarians on routine serum chemistry profiles. A parathyroid nodule was identified with cervical ultrasound in 17/17 dogs. Hypercalcaemia resolved in 18/19 dogs within 4 days postoperatively. Nine developed hypocalcaemia. None were confirmed to develop recurrent or metastatic PTC. The only death associated w...
Source: Veterinary and Comparative Oncology - December 1, 2011 Category: Veterinary Research Authors: E. S. SawyerN. C. NorthrupC. W. SchmiedtW. T. N. CulpK. M. RassnickL. D. GarrettK. A. SeltingC. F. SabaE. W. Howerth Source Type: research

Molecular diagnosis of parathyroid carcinoma: a reality in the near future
Expert Opinion on Medical Diagnostics, Volume 0, Issue 0, Page 1-11, Early Online. (Source: Expert Opinion: Expert Opinion on Medical Diagnostics)
Source: Expert Opinion: Expert Opinion on Medical Diagnostics - November 19, 2011 Category: Journals (General) Tags: article Source Type: research

Parathyroid Carcinoma: A Rare Case Report [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 18, 2011 Category: Cancer & Oncology Authors: Carman, Snyder, Levin Tags: Epidemiology, Surgery, Epidemiology, Surgery DIAGNOSIS IN ONCOLOGY Source Type: research

Parathyroid Carcinoma: A 43-Year Outcome and Survival Analysis.
Conclusion:Parathyroid cancer patients typically have a long survival, which often includes multiple reoperations for recurrence and thus a high rate of surgical complications. Patients in whom there is a high index of suspicion for parathyroid cancer should be referred to a dedicated endocrine surgery center for their initial operation. PMID: 21937626 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - September 21, 2011 Category: Endocrinology Authors: Harari A, Waring A, Fernandez-Ranvier G, Hwang J, Suh I, Mitmaker E, Shen W, Gosnell J, Duh QY, Clark O Tags: J Clin Endocrinol Metab Source Type: research

Metastatic parathyroid carcinoma initially misdiagnosed as parathyroid adenoma: the role of parafibromin in increasing diagnostic accuracy
We report a case where the diagnosis was not considered from the outset and review the current clinical and histopathological markers available to assist in the diagnosis of parathyroid carcinoma. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - September 1, 2011 Category: Internal Medicine Authors: S. LimM. S. ElstonA. J. GillD. J. MarshJ. V. Conaglen Source Type: research

Intrathyroid Parathyroid Carcinoma with Intrathyroidal Metastasis to the Contralateral Lobe: Source of Diagnostic and Treatment Pitfalls
We report a case of 40-year-old man presented with classical manifestations of primary hyperparathyroidism, severe hypercalcemia and profoundly increased serum parathyroid hormone level. Neck ultrasonography demonstrated multinodular goiter with predominant 34 mm nodule in left thyroid lobe. Additional 16 mm nodule was found beneath the left lobe. Routine percutaneous fine-needle aspiration of predominant nodule indicated follicular thyroid carcinoma, while left inferior nodule was confirmed to be of parathyroid origin. The patient underwent surgery, during which frozen sections identified medullary thyroid carcinoma with ...
Source: Japanese Journal of Clinical Oncology - August 28, 2011 Category: Cancer & Oncology Authors: Kruljac, I., Pavic, I., Matesa, N., Mirosevic, G., Maric, A., Becejac, B., Ivkic, M., Zadravec, D., Katinic, K., Vrkljan, M. Tags: Case Report Case Reports Source Type: research

Incidence and prognosis of parathyroid gland carcinoma: A population-based study in The Netherlands estimating the preoperative diagnosis
Conclusions: Parathyroid hormone levels of more than 3 times upper normal limits, palpable neck mass, and profound hypercalcemia are suspicious signs of carcinoma necessitating surgical exploration by an experienced surgeon. (Source: American Journal of Surgery)
Source: American Journal of Surgery - August 22, 2011 Category: Surgery Authors: Michael Schaapveld, Francisca H. Jorna, Katja K.H. Aben, Harm R. Haak, John T.M. Plukker, Thera P. Links Tags: Clinical Surgery Source Type: research

Detection of the first gross CDC73 germline deletion in an HPT‐JT syndrome family
AbstractHereditary primary hyperparathyroidism (HPT) may develop as a solitary endocrinopathy (FIHP) or as part of multiple endocrine neoplasia Type 1, multiple endocrine neoplasia Type 2A, or hereditary HPT‐jaw tumor syndrome. Inactivating germline mutations of the tumor suppressor gene CDC73 account for 14 and 50% of all FIHP and HPT‐JT patients, respectively, and have also been found in almost 20% of apparently sporadic parathyroid carcinoma patients. Although more than 60 independent germline mutations have been described, to date no rearrangement affecting the CDC73 locus has been identified. By means of multiplex...
Source: Genes, Chromosomes and Cancer - August 12, 2011 Category: Cancer & Oncology Authors: Alberto CascónCarlos Vázquez Huarte‐MendicoaL. Javier Leandro‐GarcíaRocío LetónJavier SuelaAlfredo SantanaMauro Boronat CostaIñaki Comino‐MéndezIñigo LandaLydia SánchezCristina Rodríguez‐AntonaJuan C. CigudosaMercedes Robledo Tags: Research Article Source Type: research

Novel nonsense CDC73 mutations in Chinese patients with parathyroid tumors
We reported two Chinese patients having parathyroid neoplasm with equivocal malignant potential and parathyroid carcinoma respectively with both germline and somatic CDC73 mutations detected. Both of them presented with severe hypercalcemia and primary hyperparathyroidism with no other HPT-JT associated tumors and negative family history. We identified one novel germline mutation CDC73 NM_024529.4: c.1475G > A; NP_078805.3: p.Trp492X and one novel somatic mutation CDC73 NM_024529.4: c.142G > T; NP_078805.3: p.Glu48X. The other germline mutation CDC73 NM_024529.4: c.226C > T; NP_0788...
Source: Familial Cancer - July 6, 2011 Category: Cancer & Oncology Tags: Familial Cancer Source Type: research

Parafibromin immunohistochemical staining to differentiate parathyroid carcinoma from parathyroid adenoma
ConclusionsLoss of parafibromin immunostating showed promising results in the differential diagnosis of parathyroid carcinoma from adenoma and may also serve as a prognostic marker. © 2011 Wiley Periodicals, Inc. Head Neck, 2011 (Source: Head and Neck)
Source: Head and Neck - June 28, 2011 Category: ENT & OMF Authors: Hee Kyung KimYoung Lyun OhSeok‐Hyung KimDong Youn LeeHo‐Cheol KangJi In LeeHye Won JangKyu Yeon HurJae Hyeon KimYong Ki MinJae Hoon ChungSun Wook Kim Tags: Original Article Source Type: research

CDC73-related hereditary hyperparathyroidism: five new mutations and the clinical spectrum.
Conclusions This series significantly increases the information available on the mutations and phenotypes of HPT-JT syndrome. PMID: 21652691 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - June 6, 2011 Category: Endocrinology Authors: Frank-Raue K, Haag C, Schulze E, Keuser R, Raue F, Dralle H, Lorenz K Tags: Eur J Endocrinol Source Type: research

The DNA methylome of benign and malignant parathyroid tumors
In conclusion, the unbiased, genome‐wide study of the parathyroid tumor DNA methylome identified a number of genes with altered DNA methylation patterns of putative importance to benign and malignant parathyroid tumorigenesis. © 2011 Wiley‐Liss, Inc. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - June 5, 2011 Category: Cancer & Oncology Authors: Lee F. StarkerJessica SvedlundRobert UdelsmanHenning DralleGöran ÅkerströmGunnar WestinRichard P. LiftonPeyman BjörklundTobias Carling Tags: Research Article Source Type: research

Nontruncated amino‐terminal parathyroid hormone overproduction in two patients with parathyroid carcinoma: a possible link to HRPT2 gene inactivation
Conclusions This may suggest that a progressive rise in third/second‐generation ratio may have possible clinical utility to monitor parathyroid cancer recurrence. A possible association between NT‐N PTH overproduction and HRPT2 gene inactivation is also suggested. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - May 15, 2011 Category: Endocrinology Authors: Philippe CaronWilliam F. SimondsJean‐Christophe MaizaMishaela RubinTom CantorLouise RousseauJohn P. BilezikianJean‐Claude SouberbiellePierre D’Amour Tags: ORIGINAL ARTICLE Source Type: research