Peptic Ulcer This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

Scoring systems for outcome prediction in patients with perforated peptic ulcer.
CONCLUSION: While the Boey score and the ASA score are most commonly used to predict outcome for PPU patients, considerable variations in accuracy for outcome prediction were shown. Other scoring systems are hampered by a lack of validation or by their complexity that precludes routine clinical use. While the PULP score seems promising it needs external validation before widespread use. PMID: 23574922 [PubMed - in process] (Source: Health Physics)
Source: Health Physics - May 23, 2013 Category: Physics Authors: Thorsen K, Søreide JA, Søreide K Tags: Scand J Trauma Resusc Emerg Med Source Type: research

Considerations in the Analysis of Hydrogen Exchange Mass Spectrometry Data
We describe the fundamental parameters to be considered at each step along the way and how data processing, either by an individual or by software, must approach the analysis. (Source: Springer protocols feed by Protein Science)
Source: Springer protocols feed by Protein Science - May 16, 2013 Category: Biochemistry Source Type: news

Perforated duodenal ulcer: A rare complication of deferasirox in children
We report a 6½-year-old male child with thalassemia major who presented to emergency room with an acute abdomen and shock, who was subsequently found to have a perforated duodenal ulcer, probably related to use of oral chelating agent, deferasirox. Although, gastrointestinal symptoms like nausea, vomiting, and abdominal pain has been mentioned as infrequent adverse event in the scientific product information of deferasirox, in our current knowledge this is the first case report of perforated duodenal ulcer after oral deferasirox. The severity of this event justifies the reporting of this case. This patient had ...
Source: Indian Journal of Pharmacology - May 15, 2013 Category: Drugs & Pharmacology Authors: Sunil Kumar YadavVipul GuptaAshraf El KohlyWasmi Al Fadhli Source Type: research

Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study
Irsogladine provides better protection against NSAID-induced small-intestinal injuries than the PPI Omeprazole in healthy subjects assessed by biochemical approaches and capsule endoscopy, suggesting it could provide protection against NSAID-induced injuries to the entire digestive tract (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - May 14, 2013 Category: Gastroenterology Authors: Takanori KuramotoEiji UmegakiSadaharu NoudaKen NarabayashiYuichi KojimaYukiko YodaKumi IshidaKen KawakamiYosuke AbeToshihisa TakeuchiTakuya InoueMitsuyuki MuranoSatoshi TokiokaKazuhide Higuchi Source Type: research

Anthocyanins from black soybean inhibit Helicobacter pylori‐induced inflammation in human gastric epithelial AGS cells
In this study, therefore, the effect of anthocyanins on H. pylori‐infected human gastric epithelial cells was examined. AGS cells were pretreated with anthocyanins for 24 hrs followed by H. pylori 26695 infection for up to 24 hrs. Cell viability and ROS production were examined by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide and 2′,7′–dichlorofluorescein diacetate assay, respectively. Western blot analyses and RT‐PCR were performed to assess gene and protein expression, respectively. IL‐8 secretion in AGS cells was measured by ELISA. It was found that anthocyanins decrease H. pyl...
Source: Microbiology and Immunology - May 14, 2013 Category: Microbiology Authors: Jung‐Min Kim, Kyung‐Mi Kim, En‐Hee Park, Ji‐Hyun Seo, Jae‐Young Song, Sung‐Chul Shin, Hyung‐Lyun Kang, Woo‐Kon Lee, Myung‐Je Cho, Kwang‐Ho Rhee, Hee‐Shang Youn, Seung‐Chul Baik Tags: Original Article Source Type: research

Genome Sequences of 65 Helicobacter pylori Strains Isolated from Asymptomatic Individuals and Patients with Gastric Cancer, Peptic Ulcer Disease, or Gastritis
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - May 9, 2013 Category: Microbiology Authors: Thomas G. Blanchard, Steven J. Czinn, Pelayo Correa, Teruko Nakazawa, Monika Keelan, Lindsay Morningstar, Ivette Santana‐Cruz, Ankit Maroo, Carri McCracken, Kent Shefchek, Sean Daugherty, Yang Song, Claire M. Fraser, W. Florian Fricke Tags: Short Communication Source Type: research

Highlights from this issue
Luminal GIOmeprazole's eosinophil-reducing properties Eosinophilic oesophagitis (EoE) and gastro-oesophageal reflux disease (GORD) share clinical and histological features and it is sometimes difficult to distinguish the two disorders, though some reports suggest that response to PPIs might be a useful test. The premise is that reduced gastric acid secretion is the only important effect of PPIs and, therefore, only an acid-peptic disorder like GORD can respond to PPIs. It is also known that oesophageal expression of eotaxin-3 stimulated by Th2 cytokines might contribute to oesophageal eosinophilia in EoE while Th2 cytokine...
Source: Gut - April 30, 2013 Category: Gastroenterology Authors: El-Omar, E., Grady, W., Gerbes, A. Tags: Digest Source Type: research

What Are Proton Pump Inhibitors?
Proton pump inhibitors (PPIs) are a group of medications that have been used to decrease the amount of acid in the stomach and intestines. Doctors prescribe PPIs to treat people with GERD, ulcers in the stomach or intestine, or other digestive disorders where the production of stomach acid needs to be controlled. Read more about what proton pump inhibitors are and what they do. Types of PPIs: Aciphex Dexilant Nexium Prevacid Prilosec Protonix Related Resources: GERD Erosive Esophagitis Zollinger-Ellison syndrome Peptic Ulcers What Are Proton Pump Inhibitors? originally appeared on About.com Heartburn / GE...
Source: About Heartburn / Acid Reflux - April 29, 2013 Category: Consumer Health Advice Source Type: news

What Are H2 Blockers?
H2 blockers, which are also called H2-receptor antagonists, are medicines used to reduce the amount of acid the stomach produces. The H2-blockers block histamine's ability to bind to one kind of histamine receptor on cells: the histamine-2 receptor. Learn what H2 blockers are and what they do. Types of H2 blockers: Axid Pepcid Tagamet Zantac Related Resources: What is Heartburn? What is GERD What is Erosive Esophagitis What is Zollinger-Ellison syndrome What are Peptic Ulcers What Are H2 Blockers? originally appeared on About.com Heartburn / GERD on Monday, April 29th, 2013 at 22:00:47.Permalink | Comment...
Source: About Heartburn / Acid Reflux - April 29, 2013 Category: Consumer Health Advice Source Type: news

Helicobacter pylori Infection – A Boon or a Bane: Lessons from Studies in a Low‐Prevalence Population
Abstract Helicobacter pylori (H. pylori) infection is etiologically associated with gastric cancer and peptic ulcer diseases which are both important public health burdens which could be largely eliminated by H. pylori eradication. However, some investigators urge caution based on the hypothesis that eradication of H. pylori may result in an increase in the incidence of gastroesophageal reflux disease, esophageal adenocarcinoma, and childhood asthma. The ethnic Malays of northeastern Peninsular Malaysia have long had a low prevalence of H. pylori infection and, as expected, the incidence of gastric cancer and its precu...
Source: Helicobacter - April 26, 2013 Category: Gastroenterology Authors: Yeong Yeh Lee, Sundramoorthy Mahendra Raj, David Y. Graham Tags: Review Source Type: research

Basil Isaac Hirschowitz, MD
Dr. Basil Isaac Hirschowitz, a true pioneer of gastroenterology, died on January 19, 2013, at the age of 87 years. His entire academic career was devoted to the critical study of the physiology, pharmacology, diagnosis, and management of diseases of the upper gastrointestinal tract, much of it related to peptic ulcer disease. He will be best remembered for his creation of the fiberoptic endoscope, which revolutionized gastroenterology research, practice, and patient care. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 13, 2013 Category: Gastroenterology Authors: C. Mel Wilcox, Charles O. Elson Tags: In Memoriam Source Type: research

Scoring systems for outcome prediction in patients with perforated peptic ulcer
Conclusion: While the Boey score and the ASA score are most commonly used to predict outcome for PPU patients, considerable variations in accuracy for outcome prediction were shown. Other scoring systems are hampered by a lack of validation or by their complexity that precludes routine clinical use. While the PULP score seems promising it needs external validation before widespread use. (Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine)
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - April 10, 2013 Category: Emergency Medicine Authors: Kenneth ThorsenJon Arne SøreideKjetil Søreide Source Type: research

Fluoxetine Inhibition of CYP3A4 Potentiating Adrenal Suppression and Peptic Ulcer Disease from Intra‐Articular Triamcinolone Injections
(Source: Pain Medicine)
Source: Pain Medicine - April 8, 2013 Category: Anesthesiology Authors: Thorsten M. Leucker, Sanjeev Singh, Bryan K. Moffett Tags: Letter to the Editor Source Type: research

Hightlights from this issue
Luminal GIBenefits of mass eradication of H pylori infection What are the benefits and risks of mass eradication of H pylori infection in the community? In this issue of Gut, Lee et al attempt to answer this question with a unique study from Taiwan. Mass eradication (chemoprevention) of H pylori infection was started from 2004 for 5000 residents of Matsu Island who were >30 years of age. The main outcome measures were changes in the prevalence and incidence of H pylori infection and premalignant gastric lesions before (1995–2003) and after (2004–2008) chemoprevention. Eradication of H pylori infection substa...
Source: Gut - April 2, 2013 Category: Gastroenterology Authors: El-Omar, E., Grady, W., Gerbes, A. Tags: Digest Source Type: research

The benefit of mass eradication of Helicobacter pylori infection: a community-based study of gastric cancer prevention
Conclusions Population-based eradication of H pylori infection has led to a significant reduction in gastric atrophy at the expense of increased oesophagitis. The ultimate benefit in reducing gastric cancer incidence and its mortality should be validated by a further long-term follow-up. Trial registration number NCT00155389. (Source: Gut)
Source: Gut - April 2, 2013 Category: Gastroenterology Authors: Lee, Y.-C., Chen, T. H.-H., Chiu, H.-M., Shun, C.-T., Chiang, H., Liu, T.-Y., Wu, M.-S., Lin, J.-T. Tags: Ulcer, Open access, Stomach and duodenum, Pancreatic cancer Helicobacter pylori Source Type: research

Highlights from this issue
Luminal GIBenefits of mass eradication of H pylori infection What are the benefits and risks of mass eradication of H pylori infection in the community? In this issue of Gut, Lee et al attempt to answer this question with a unique study from Taiwan. Mass eradication (chemoprevention) of H pylori infection was started from 2004 for 5000 residents of Matsu Island who were >30 years of age. The main outcome measures were changes in the prevalence and incidence of H pylori infection and premalignant gastric lesions before (1995–2003) and after (2004–2008) chemoprevention. Eradication of H pylori infection substa...
Source: Gut - April 2, 2013 Category: Gastroenterology Authors: El-Omar, E., Grady, W., Gerbes, A. Tags: Digest Source Type: research

Effect of Fluoroquinolone Resistance on 14‐day Levofloxacin Triple and Triple Plus Bismuth Quadruple Therapy
ConclusionsFourteen‐day fluoroquinolone therapy was highly effective when fluoroquinolone resistance rates are <12%. The addition of bismuth maintained effectiveness with fluoroquinolone resistance as high as 25%. (Source: Helicobacter)
Source: Helicobacter - April 1, 2013 Category: Gastroenterology Authors: Jingxian Liao, Qing Zheng, Xiao Liang, Wei Zhang, Qinjuan Sun, Wenzhong Liu, Shudong Xiao, David Y. Graham, Hong Lu Tags: Original Article Source Type: research

On Helicobacter pylori seropositivity in patients with chronic obstructive pulmonary disease
In a recent interesting paper, Siva et al. have explored one aspect regarding the intriguing issue of extragastric manifestations of Helicobacter pylori (H. pylori) infection. In an audit on 329 miners, the authors reviewed primary care medical records and perfomed both full lung function tests and the search for antibodies to H. pylori in serum. Subsequently, a case‐control design was applied. Cases were patients with a prior diagnosis of chronic obstructive pulmonary disease (COPD). The control population was represented by subjects with normal spirometric values. The authors reported that there was a strong and indepe...
Source: Respirology - April 1, 2013 Category: Respiratory Medicine Authors: Rinaldo Pellicano, Sharmila Fagoonee Tags: Correspondence Source Type: research

A link between physician-diagnosed ulcer and anxiety disorders among adults.
CONCLUSIONS: These findings provide initial evidence of a link between anxiety disorders and physician-diagnosed ulcer among adults in the community. Future work, ideally taking into account Helicobacter pylori infection, stress, and mental health problems is needed to improve our understanding of the possible mechanisms that can provide insight into the etiology of peptic ulcers. PMID: 23453387 [PubMed - in process] (Source: Annals of Epidemiology)
Source: Annals of Epidemiology - April 1, 2013 Category: Epidemiology Authors: Goodwin RD, Talley NJ, Hotopf M, Cowles RA, Galea S, Jacobi F Tags: Ann Epidemiol Source Type: research

Anthocyanins from black soybean inhibit Helicobacter pylori‐induced inflammation in human gastric epithelial AGS cells
In this study, therefore, we examined the effect of anthocyanins on H. pylori‐infected human gastric epithelial cells. AGS cells were pretreated with anthocyanins for 24 hours followed by H. pylori 26695 infection for up to 24 hours. Cell viability and ROS production were examined by MTT and DCF‐DA assay, respectively. Western blot analyses and RT‐PCR were performed to assess gene and protein expression, respectively. IL‐8 secretion in AGS cells was measured by ELISA. We found that anthocyanins decreased H. pylori‐induced ROS enhancement. Anthocyanins also inhibited phosphorylation of mitogen‐activated protein ...
Source: Microbiology and Immunology - March 28, 2013 Category: Microbiology Authors: Jung‐Min Kim, Kyung‐Mi Kim, En‐Hee Park, Ji‐Hyun Seo, Jae‐Young Song, Sung‐Chul Shin, Hyung‐Lyun Kang, Woo‐Kon Lee, Myung‐Je Cho, Kwang‐Ho Rhee, Hee‐Shang Youn, Seung‐Chul Baik Tags: Original Article Source Type: research

Safety and efficacy of long-term esomeprazole 20¿mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs
Conclusion: Long-term treatment with esomeprazole (20 mg once daily) is well tolerated and efficacious for preventing ulcer recurrence in Japanese NSAID users with a history of peptic ulcer.Trial registrationClinicalTrials.gov identifier NCT00595517. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - March 26, 2013 Category: Gastroenterology Authors: Kentaro SuganoYoshikazu KinoshitaHiroto MiwaTsutomu Takeuchi Source Type: research

Is the microbe-dementia hypothesis finally ready for a treatment trial?
Could infections really have something to do with disorders that cause dementia? Several chronic diseases, such as peptic ulcer, certain cancers, and autoimmune conditions, have established infectious etiologies, either bacterial or viral, but mainstream cognitive disorder research has not fully considered microbial involvement. Evidence is emerging,1 but the size of the problem—millions of patients with Alzheimer disease (AD) worldwide, and increasing—compels searching for clues in the dark, and not only below the streetlight, especially if established and safe treatments are available. (Source: Neurology)
Source: Neurology - March 25, 2013 Category: Neurology Authors: Strandberg, T. E., Aiello, A. E. Tags: All Infections, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia EDITORIALS Source Type: research

Amino acid polymorphisms flanking the EPIYA‐A motif of Helicobacter pylori CagA C‐terminal region is associated with gastric cancer in East China
ConclusionThe majority of H. pylori strains present in East China are of the CagA‐ABD subtype. Polymorphisms at amino acids 878 and 879 flanking the EPIYA‐A motif are statistically associated with gastric cancer. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - March 21, 2013 Category: Gastroenterology Authors: Chun Yan Chen, Fang Yu Wang, Hai Jun Wan, Xin Xin Jin, Juan Wei, Zhen Kai Wang, Chang Liu, Heng Lu, Hui Shi, Dong Hai Li, Jiong Liu Tags: Original Article Source Type: research

Vulnerability of gastric mucosa in diabetic rats, its pathogenesis and amelioration by Cuminum cyminum
This study is the first attempt to understand the pathogenesis of gastric ulcers occurring during the diabetic state considering alternate biochemical pathways using suitable markers and its amelioration by Cuminum cyminum. In this study, diabetic rats showed a progressive increase in the stomach advanced glycated end products formation, gastric mucosal tumour necrosis factor-α and Thiobarbituric acid reactive substances levels as compared to normal control (nondiabetic) rats. There was decrease in gastric mucosal content, antioxidant enzymes and cellular ATPase enzyme levels of diabetic gastric mucosa when com...
Source: Indian Journal of Pharmaceutical Sciences - March 12, 2013 Category: Drugs & Pharmacology Authors: N VadorAarti G JagtapArchana Damle Source Type: research

Diabetes is an independent risk factor for peptic ulcer bleeding : a nationwide population‐based cohort study
ConclusionsType II diabetic patients have significantly higher risk of PUB even after adjustments for possible confounding factors like age, sex, underlying co‐morbidities, and ulcerogenic medication. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - March 11, 2013 Category: Gastroenterology Authors: Yen‐Ling Peng, Hsin‐Bang Leu, Jiing‐Chyuan Luo, Chin‐Chou Huang, Ming‐Chih Hou, Han‐Chieh Lin, Fa‐Yauh Lee Tags: Clinical Gastroenterology Source Type: research

Emergent laparoscopy in treatment of perforated peptic ulcer: a local experience from a tertiary centre in Saudi Arabia
Conclusions: Laparoscopic repair of a perforated peptic ulcer is an amenable and feasible technique within the hands of experienced laparoscopic surgeon when the cases are early and properly diagnosed. (Source: World Journal of Emergency Surgery)
Source: World Journal of Emergency Surgery - March 8, 2013 Category: Emergency Medicine Authors: Hamed Wadaani Source Type: research

Soluble soy protein peptic hydrolysate stimulates adipocyte differentiation in 3T3‐L1 cells
ConclusionThese findings indicate that SPH stimulates adipocyte differentiation, at least in part, via the up‐regulation of PPARγ expression levels. These effects of SPH might be important for the health benefit effects of soybean proteins on obesity‐associated metabolic disorders. (Source: Nahrung / Food)
Source: Nahrung / Food - March 8, 2013 Category: Nutrition Authors: Tsuyoshi Goto, Ayaka Mori, Satoshi Nagaoka Tags: Research Article Source Type: research

Acute perforated peptic ulcer: On clinical experience in an urban tertiary hospital in south east Nigeria
Conclusion: Patient groups who presented early had low mortality rates, but patient groups who presented late had higher mortality rates. Overall mortality was 21%. (Source: International Journal of Surgery)
Source: International Journal of Surgery - March 4, 2013 Category: Surgery Authors: A.I. Ugochukwu, O.C. Amu, M.A. Nzegwu, U.C. Dilibe Tags: Reviews Source Type: research

A link between physician-diagnosed ulcer and anxiety disorders among adults
Conclusions: These findings provide initial evidence of a link between anxiety disorders and physician-diagnosed ulcer among adults in the community. Future work, ideally taking into account Helicobacter pylori infection, stress, and mental health problems is needed to improve our understanding of the possible mechanisms that can provide insight into the etiology of peptic ulcers. (Source: Annals of Epidemiology)
Source: Annals of Epidemiology - March 4, 2013 Category: Epidemiology Authors: Renee D. Goodwin, Nicholas J. Talley, Matthew Hotopf, Robert A. Cowles, Sandro Galea, Frank Jacobi Source Type: research

Esomeprazole for Prevention and Resolution of Upper Gastrointestinal Symptoms in Patients Treated With Low-dose Acetylsalicylic Acid for Cardiovascular Protection: The OBERON Trial
Abstract: Although low-dose acetylsalicylic acid (ASA) is recommended for prevention of cardiovascular events in at-risk patients, its long-term use can be associated with the risk of peptic ulcer and upper gastrointestinal (GI) symptoms that may impact treatment compliance. This prespecified secondary analysis of the OBERON study (NCT00441727) determined the efficacy of esomeprazole for prevention/resolution of low-dose ASA-associated upper GI symptoms. A post hoc analysis of predictors of symptom prevention/resolution was also conducted. Helicobacter pylori–negative patients taking low-dose ASA (75–325 mg) for cardio...
Source: Journal of Cardiovascular Pharmacology - March 1, 2013 Category: Cardiology Tags: Original Article Source Type: research

Clinical utility of curcumin extract.
This article reviews the pharmacology of curcuminoids, their use and efficacy, potential adverse effects, and dosage and standardization. Preclinical studies point to mechanisms of action that are predominantly anti-inflammatory and antineoplastic, while early human clinical trials suggest beneficial effects for dyspepsia, peptic ulcer, inflammatory bowel disease, rheumatoid arthritis, osteoarthritis, uveitis, orbital pseudotumor, and pancreatic cancer. Curcumin is well-tolerated; the most common side effects are nausea and diarrhea. Theoretical interactions exist due to purported effects on metabolic enzymes and transport...
Source: Alternative Therapies in Health and Medicine - March 1, 2013 Category: Complementary Medicine Authors: Asher GN, Spelman K Tags: Altern Ther Health Med Source Type: research

What the world needs now…is more access to the levonorgestrel IUD
I remember attending a lecture 15 years ago on the future of medicine. I was fresh out of residency and the lecturer talked about five medical interventions that were currently taken for granted but were unheard of 15 years earlier. His point: We do not know what the future holds but we must be ready to utilize advances as they occur. At the time, I had never heard of the levonorgestrel intrauterine device (LNG IUD). Young physicians and advanced practice clinicians graduating from training programs in 2013 would be challenged to consider a world without the LNG IUD, just as I was challenged in 1998 to imagine a world with...
Source: Contraception - February 25, 2013 Category: OBGYN Authors: David K. Turok Tags: Editorial Source Type: research

Expert position paper on use of proton pump inhibitors in patients with cardiovascular disease and antithrombotic therapy
Source: Eur Heart J Area: News The European Society of Cardiology NSTEMI and STEMI guidelines and an ACCF/ACG/AHA consensus document recommend treatment with proton pump inhibitors (PPIs) in patients treated with dual antiplatelet treatment (DAPT) during the initial phase of an acute coronary syndrome (ACS), particularly in patients with a history of GI bleeding or peptic ulcer. Several studies have raised concerns that many PPIs, especially omeprazole, might diminish the antiplatelet effects of clopidogrel, most likely through inhibition of CYP2C19 and, consequently, the conversion of clopidogrel into its active metaboli...
Source: NeLM - Cardiovascular Medicine - February 21, 2013 Category: Cardiology Source Type: news

Changing epidemiology of food bolus impaction: Is eosinophilic esophagitis to blame?
ConclusionsThe prevalence of FBI has increased over the last 15 years. This was associated with an increased prevalence of EoE, and, a reduction in age of presentation and peptic‐related strictures. These findings suggest EoE is an important cause of FBI and that esophageal mucosal biopsy should be performed in all cases of FBI. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 21, 2013 Category: Gastroenterology Authors: Venkat N. Mahesh, Richard H. Holloway, Nam Quoc Nguyen Tags: Clinical Gastroenterology Source Type: research

The aspirin cardiovascular/gastrointestinal risk calculator ‐ a tool to aid clinicians in practice
ConclusionsThere are many clinical situations where the number of potential upper GI complications induced by low‐dose aspirin may exceed the number of potentially prevented CV events. A risk calculator should guide physicians in choosing appropriate therapy and maximise the aspirin benefit. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 19, 2013 Category: Drugs & Pharmacology Authors: A. Lanas, M. Polo‐Tomás, R. Casado‐Arroyo Tags: Original Article Source Type: research

Salivary IgG assay to detect Helicobacter pylori infection in an Indian adult population
Conclusion: EIAgen H. pylori IgG assay is a noninvasive, moderately accurate, and sensitive method for the detection of H. pylori infection in saliva. Salivary anti H. pylori IgG test prior to endoscopy is a useful screening test for seroepidemiological studies. (Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3))
Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3) - February 19, 2013 Category: Dentistry Authors: Ramya Thirumala KrishnaswamyChaya Manoranjini DavidSavitha GovindaiahRamnarayan Belur KrishnaprasadSanjay Chikkarasinakere Jogigowda Source Type: research

Sleep Apnea and Risk of Peptic Ulcer Bleeding: A Nationwide Population-based Study
Abstract: Objective: Patients with sleep apnea sustain cessation of breath during sleep, leading to intermittent hypoxia, systemic inflammation, and sympathetic activation. These insults may contribute to initiation or progression of peptic ulcers. This retrospective matched-control cohort study explored the relationship of sleep apnea and subsequent development of peptic ulcer bleeding. Methods: From 2000 to 2009, patients with newly diagnosed sleep apnea were identified from the Taiwan National Health Insurance Research Database. A control group without sleep apnea, matched for age, gender, comorbidities, and medicat...
Source: The American Journal of Medicine - February 15, 2013 Category: Journals (General) Authors: Tsu-Hui Shiao, Chia-Jen Liu, Jiing-Chyuan Luo, Kang-Cheng Su, Yuh-Min Chen, Tzeng-Ji Chen, Kun-Ta Chou, Guang-Ming Shiao, Yu-Chin Lee Tags: Clinical research studies Source Type: research

Nonpeptic Ulcer, Nonvariceal Gastrointestinal Bleeding in Hemodialysis Patients
Abstract: Objectives: Hemodialysis patients carry a higher risk of peptic ulcer bleeding. Whether hemodialysis patients also have a higher occurrence of nonpeptic ulcer, nonvariceal gastrointestinal bleeding needs further evaluation. Methods: Using Taiwan's National Health Insurance research database, the occurrence of nonpeptic ulcer, nonvariceal gastrointestinal bleeding was compared among the hemodialysis patients, chronic kidney disease patients, and controls using log-rank test. Risk factors were identified by Cox regression analysis. Results: A total of 20,830 patients were enrolled, including 8210 hemodialysis...
Source: The American Journal of Medicine - February 15, 2013 Category: Journals (General) Authors: Jiing-Chyuan Luo, Hsin-Bang Leu, Ming-Chih Hou, Kuang-Wei Huang, Han-Chieh Lin, Fa-Yauh Lee, Wan-Leong Chan, Shing-Jong Lin, Jaw-Wen Chen Tags: Clinical research studies Source Type: research

Trends in Gastrectomy and ADH1B and ALDH2 Genotypes in Japanese Alcoholic Men and Their Gene-gastrectomy, Gene-gene and Gene-age Interactions for Risk of Alcoholism
Conclusions: The high frequency of history of gastrectomy suggested that gastrectomy is still a risk factor for alcoholism, although the percentage decreased during the period. The alcoholism-susceptibility genotype ADH1B*1/*1 was less frequent in the gastrectomy group, suggesting a competitive gene–gastrectomy interaction for alcoholism. A gene–gene interaction and gene–age interactions regarding the ADH1B genotype were observed. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - February 13, 2013 Category: Addiction Authors: Yokoyama, A., Yokoyama, T., Matsui, T., Mizukami, T., Kimura, M., Matsushita, S., Higuchi, S., Maruyama, K. Tags: GENETICS AND CELL BIOLOGY Source Type: research

Some Reassurance About Proton Pump Inhibitors and Risk of Osteoporotic Fractures
Despite limitations, this study lends some reassurance that risk of osteoporosis is not likely to overshadow the benefit of proton pump inhibitors in preventing recurrent peptic ulcer, esophageal reflux symptoms, and esophageal cancer risk. (Source: Consultant Live)
Source: Consultant Live - February 11, 2013 Category: Primary Care Source Type: news

'Bad' Gut Bacteria May Help Control Diabetes
A stomach bacterium believed to cause health problems such as gastritis, ulcers, and gastric cancer may play a dual role by balancing the stomach's ecosystem and controlling body weight and glucose tolerance, according to immunologists at the Virginia Bioinformatics Institute of Virginia Tech. Usually the villain in studies of gastric cancer and peptic ulcers, Helicobacter pylori infect about half of the world's population although most infected individuals don't get sick. The bacterium's dwindling numbers coincide with the epidemic of obesity and diabetes in developed countries. "H... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 10, 2013 Category: Consumer Health News Tags: Diabetes Source Type: news

The impact of autophagic processes on the intracellular fate of Helicobacter pylori: More tricks from an enigmatic pathogen?
Abstract Helicobacter pylori is a Gram-negative pathogen that colonizes the gastric epithelium of 50-60% of the world's population. Approximately one-fifth of the infected individuals manifest severe diseases such as peptic ulcers or gastric cancer. H. pylori infection has proven difficult to cure despite intensive antibiotic treatment. One possible reason for the relatively high resistance to antimicrobial therapy is the ability of H. pylori to reside inside host cells. Although considered by most as an extracellular pathogen, H. pylori can invade both gastric epithelial cells and immunocytes to some extent. The i...
Source: Autophagy - February 8, 2013 Category: Cytology Authors: Deen NS, Huang SJ, Gong L, Kwok T, Devenish RJ Tags: Autophagy Source Type: research

The Evolving Challenges of Helicobacter pylori Disease, Diagnostics, and Treatment, Part II
Abstract: Helicobacter pylori infects half of the world's population; is associated with several severe gastric illnesses, including peptic ulcer disease and gastric cancer; and causes significant morbidity in its host. Several trends in the field of H. pylori have evolved recently, drastically changing the way that these infections are managed. Part I of this article was published in the February 1, 2013 issue of Clinical Microbiology Newsletter (Vol. 35, No. 3) and provided a concise overview of the pathogenesis and epidemiology of the disease, as well as a review of recommendations for the use of laboratory tests f...
Source: Clinical Microbiology Newsletter - February 6, 2013 Category: Microbiology Authors: Marc Roger Couturier Source Type: news

What You Need to Know About Heartburn Related Digestive Disorders
Talking to your doctor is important whenever you have a concern about your health. If that concern is connected to your digestive system, particularly that which is related to the symptom of heartburn, then this information on heartburn related digestive disorders can give you some ideas of what questions to ask your doctor, and may answer some of your questions now. Related Information: What is GERD? What is a hiatal hernia? What are peptic ulcers? What are gallstones? What You Need to Know About Heartburn Related Digestive Disorders originally appeared on About.com Heartburn / GERD on Wednesday, February 6t...
Source: About Heartburn / Acid Reflux - February 6, 2013 Category: Consumer Health Advice Source Type: news

What Are Your Stomach Pain Symptoms Trying to Tell You?
If you are suffering from stomach pain, you need to find the cause before you can start a treatment. Here are a few of the conditions that can cause stomach pain. Heartburn Related Resources: Meal Planning Tips for Preventing Heartburn Dining Out Without Heartburn Foods with Little Risk of Causing Heartburn Preventing Nighttime Heartburn Peptic Ulcer Related Resources Surgery for Peptic Ulcers Complications of Peptic Ulcers Peptic Ulcer Warning Signs Peptic Ulcers in Children Gallstone Related Resources: What is the Gallbladder? What are Gallstones? What Increases the Risk of Developing G...
Source: About Heartburn / Acid Reflux - February 6, 2013 Category: Consumer Health Advice Source Type: news

Causes of Heartburn
You've just enjoyed a big meal and are relaxing in front of the TV when it happens. A burning sensation begins to build in the upper abdomen, behind the breastbone, and makes your chest feel like it's on fire. The burning and pain may travel from your diaphragm all the way to your throat, and may be accompanied with a sour taste and the sensation of food re-entering your mouth. You're suffering from severe heartburn. Despite the name, heartburn has nothing to do with the heart. It's a digestive problem that occurs when stomach acid comes into contact with the lining of the esophagus, causing irritation. Most people suffe...
Source: About Heartburn / Acid Reflux - February 6, 2013 Category: Consumer Health Advice Source Type: news

Haematemesis and melaena
Abstract: Upper gastrointestinal (UGI) haemorrhage is common and carries a significant mortality. Peptic ulcer disease remains the most common aetiology but varices are an important cause. The patient's history, physiology and blood results guide timing of endoscopy and may disclose underlying liver disease. Resuscitation and risk assessment with the Blatchford and Rockall scores are the main priorities in the acute presentation. Haemodynamically unstable patients, and patients with suspected bleeding varices should have urgent endoscopy immediately after resuscitation. Patients with a Blatchford score of 0 may be able to ...
Source: Medicine - February 1, 2013 Category: Internal Medicine Authors: Eleanor F. Watson, Nicholas I. Church Tags: Common medical presentations Source Type: research

Practical Guide to Supportive Care of Patients With Functional Neuroendocrine Tumors
Supportive care of patients with functional neuroendocrine tumors (NETs) has evolved to include the use of multiple targeted agents to control paraneoplastic states and newer surgical and interventional radiologic techniques to reduce tumor bulk. Challenges encountered by the clinician are the recognition of specific symptom complexes, selecting the relevant laboratory tests and radiologic/scintigraphic scans, and the timing of intervention(s). Individual variables such as the severity of symptoms in the context of primary and metastatic disease sites, tumor bulk, comorbidities, and previous treatment are factors determini...
Source: Seminars in Oncology - February 1, 2013 Category: Cancer & Oncology Authors: Lowell B. Anthony Tags: Emily K. Bergsland, MD, Guest Editor Source Type: research

The Effects of Multistrain Probiotic Compound on Bismuth‐Containing Quadruple Therapy for Helicobacter pylori Infection: A Randomized Placebo‐Controlled Triple‐Blind Study
ConclusionsIn overall, our studied multistrain probiotic compound has not beneficial effects in the treatment of H. pylori infection. It might be related to the low dosage of our probiotic regimen and/or high frequency of upper gastrointestinal adverse effects which in turn could decrease the eradication efficacy. (Source: Helicobacter)
Source: Helicobacter - February 1, 2013 Category: Gastroenterology Authors: Ahmad Shavakhi, Elham Tabesh, Arezoo Yaghoutkar, Houriye Hashemi, Faezeh Tabesh, Mahsa Khodadoostan, Mohammad Minakari, Sara Shavakhi, Ali Gholamrezaei Tags: Original Article Source Type: research

Peptic ulceration, Helicobacter Pylori seropositivity and Chronic Obstructive Pulmonary Disease
ConclusionsOur findings suggest a relationship between peptic ulcer disease and COPD that is more that just a shared susceptibility to different environmental stimuli. (Source: Respirology)
Source: Respirology - February 1, 2013 Category: Respiratory Medicine Authors: R Siva, S S Birring, M Berry, A Rowbottom, I D Pavord Tags: Original Article Source Type: research