Peripheral Vascular Disease (PVD) This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

Zilver Stent Recalled, System May Break
(MedPage Today) -- Cook Medical's Zilver PTX drug-eluting stent for peripheral artery disease has been recalled because of a defect in its associated delivery system, the company and the FDA said. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - May 24, 2013 Category: Consumer Health News Source Type: news

Review of an article: One-year effect of a supervised exercise programme on functional capacity and quality of life in peripheral arterial disease by Marie Guidon, MSc, PhD, Hannah McGee, PhD (Disabil Rehabil 2013;35:397–404)
Peripheral artery disease (PAD) is a prevalent, progressive, atherosclerotic disorder characterized by pain with physical activity, potential limb loss, and a high rate of morbidity and mortality. Claudication is the most common symptom of PAD and is defined as the reproducible limb fatigue, discomfort, or pain that occurs during physical activity, most often walking, and subsides with rest. Individuals with PAD and claudication experience significant limitations in their physical functioning and decrements in quality of life. (Source: Journal of Vascular Nursing)
Source: Journal of Vascular Nursing - May 24, 2013 Category: Nursing Authors: Laura Nelson Kirk Tags: Research Column Source Type: research

Measurement validity and statistical significance for nutritional factors in peripheral artery disease
Oka and Alley published a study recently in the Journal of Vascular Nursing that concluded, “Findings from our study suggest that the nutritional intake of PAD patients differs based on gender and BMI,” and “Additionally, EAR was lower for specific nutrients than recommended.” However, those conclusions were not warranted by the data in the study because the study had (1) low measurement validity, (2) no statistically significant findings because of Type II error, and (3) no data or statistical findings related to nutritional intake of the different genders. (Source: Journal of Vascular Nursing)
Source: Journal of Vascular Nursing - May 24, 2013 Category: Nursing Authors: Jennifer R. Trotter, L. Lee Glenn Tags: Letters to the Editor Source Type: research

Vascular, downstream, and pharmacokinetic responses to treatment with a low dose drug‐coated balloon in a swine femoral artery model
Conclusions: The findings indicate desired pharmacologic levels with biologic effects at early and healing at late time points in the treated arteries, without evidence of significant downstream emboli or systemic toxicity, consistent with safety of the Lutonix DCB. © 2013 Wiley Periodicals, Inc. (Source: Catheterization and Cardiovascular Interventions)
Source: Catheterization and Cardiovascular Interventions - May 22, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Saami K. Yazdani, Erica Pacheco, Masataka Nakano, Fumiyuki Otsuka, Scott Naisbitt, Frank D. Kolodgie, Elena Ladich, Serge Rousselle, Renu Virmani Tags: Original Studies Source Type: research

Oxidation-Specific Biomarkers and Risk of Peripheral Artery Disease
ConclusionsOxPL/apoB were positively associated with risk of PAD in men and women. The major lipoprotein carrier of OxPL, Lp(a), was also associated with risk of PAD, reinforcing the key role of OxPL in the pathophysiology of atherosclerosis mediated by Lp(a). (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - May 20, 2013 Category: Cardiology Source Type: research

Control of Angiogenesis Dictated by Picomolar Superoxide Levels.
Abstract Control of vascular insufficiencies due to various cardiovascular pathologies is important for developing specific and effective treatments. Fluctuations in oxidative stress significantly alter the progression of angiogenesis under physiological and pathological conditions. However, the precise amount of reactive oxygen species (ROS) required to influence subsequent signaling pathways for ischemic angiogenesis remain undefined. Here, we have determined the effect of ROS mediated molecular mechanisms on angiogenesis in a murine model of peripheral artery disease using Gclm mutant mice (a model of compromise...
Source: Free Radical Biology and Medicine - May 16, 2013 Category: Biology Authors: Bir SC, Shen X, Kavanagh TJ, Kevil CG, Pattillo CB Tags: Free Radic Biol Med Source Type: research

Four-Limb Blood Pressure Measurement: A Research Tool Looking for Clinical Use [Editorial Commentaries]
(Source: Hypertension)
Source: Hypertension - May 15, 2013 Category: Cardiology Authors: Clark, C. E. Tags: Pathophysiology, Other hypertension, Peripheral vascular disease, Other diagnostic testing Editorial Commentaries Source Type: research

Four-Limb Blood Pressure as Predictors of Mortality in Elderly Chinese [Epidemiology/Population Science]
In conclusion, in the elderly, above and beyond arm BP level and together with ankle-brachial index, the interarm and interankle BP differences improve prediction of mortality. Simultaneous 4-limb BP measurement has become feasible with current technology and might be useful in cardiovascular prevention. (Source: Hypertension)
Source: Hypertension - May 15, 2013 Category: Cardiology Authors: Sheng, C.-S., Liu, M., Zeng, W.-F., Huang, Q.-F., Li, Y., Wang, J.-G. Tags: Peripheral vascular disease Epidemiology/Population Science Source Type: research

Cilostazol prevents foot ulcers in diabetic patients with peripheral vascular disease
Abstract Diabetic patients are at the high risk of foot ulcerations that may lead to limb amputations with important socio economic impact. Peripheral vascular disease may be frequently associated in diabetes mellitus type II with its main symptom, intermittent claudication. Many studies reported the known efficacy of cilostazol in treating vascular claudication. Metalloproteinase‐9 (MMP‐9) seems to be a biochemical marker implicated in chronic wounds and in particular in diabetic foot ulcers. Cilostazol seems to have also a lowering effect on levels of MMP‐9 and this may suggest a beneficial effect in order to preve...
Source: International Wound Journal - May 15, 2013 Category: Surgery Authors: Stefano de Franciscis, Luca Gallelli, Luigi Battaglia, Vincenzo Molinari, Rossella Montemurro, Domenico M. Stillitano, Gianluca Buffone, Raffaele Serra Tags: ORIGINAL ARTICLE Source Type: research

Jetstream® atherectomy for subacutely or chronically occluded femoro‐popliteal prosthetic bypass grafts
We present three patients with occluded femoro‐popliteal graft in whom the Jetstream® system was used successfully to perform thromboatherectomy. The Jetstream® system is minimally invasive and avoids use of thrombolytic therapy and its associated costs and complications. The device seems to be highly effective in removing thrombus beyond the acute setting. © 2013 Wiley Periodicals Inc. (Source: Catheterization and Cardiovascular Interventions)
Source: Catheterization and Cardiovascular Interventions - May 15, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Mauricio Obon‐Dent, Eduardo Hernandez‐Vila Tags: Peripheral Vascular Disease Source Type: research

Abstract 31: Patterns Of Healthcare Resource Utilization Among Adults With Type 2 Diabetes Mellitus At Risk Of Cardiovascular Events In The Large Population-based Study To Help Improve Early Evaluation And Management Of Risk Factors Leading To Diabetes (SHIELD) [Poster Session I]
Conclusions: CVD events among T2DM patients continue to represent a very high economic burden on the healthcare system. HRU is very high among adults with T2DM at-risk of CVD events and significantly higher among those who had a new CVD event within 3 and 5 years compared with those who did not have a new CVD event. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Fox, K. M., Wu, Y., Kim, J., Grandy, S. Tags: Poster Session I Source Type: research

Abstract 47: Presentation and Outcomes of Women Veterans with Suspected Ischemia and Nonobstructive Coronary Artery Disease: Insights from the VA Clinical Assessment Reporting and Tracking Program. [Poster Session I]
Conclusion: Between October 2007 and September 2011, 23% of women veterans undergoing catheterization for suspected ischemia had non-obstructive CAD. In contrast to non-VA studies, adverse clinical outcomes and re-hospitalization rates for chest pain were less frequent. These findings may represent systematic differences in treatment and follow-up care of women veterans between VA and non-VA healthcare systems. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Nkonde-Price, C., Plomondon, M., Maddox, T. M., Rumsfeld, J., Duvernoy, C. Tags: Poster Session I Source Type: research

Abstract 50: Cardiovascular Event Rates Among Adults with Type 2 Diabetes Mellitus at Risk of Cardiovascular Events in the Large Population-based Study to Help Improve Early Evaluation and Management of Risk Factors Leading to Diabetes (SHIELD) [Poster Session I]
Conclusions: T2DM individuals at risk for CVD events had significant incidence of MI, stroke, and revascularization in this large US population-based study. T2DM adults with established CVD are at higher risk of CVD events than those with no CVD but have multiple risk factors. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Fox, K. M., Wu, Y., Kim, J., Grandy, S. Tags: Poster Session I Source Type: research

Abstract 53: Health Care Utilization and Cost among Type 2 Diabetes Mellitus (T2DM) Patients with Cardiovascular Disease (CVD) or Cardiovascular Disease Risk Factors [Poster Session I]
CV events among T2DM patients are major contributors to high healthcare utilization and cost. Healthcare utilization and costs among T2DM patients with established CVD and CVD risk factors in a large US database were explored.T2DM patients aged ≥40 years were identified from the HealthCore Integrated Research Environment from 1/1/2007 to 4/30/2011 and followed from first T2DM diagnosis (index date) until loss of eligibility or death. Established CVD [Group 1] included patients with MI, stroke, peripheral vascular disease, coronary heart disease, congestive heart failure, or revascularization in the year prior to index. ...
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Kern, D. M., DeVore, S., Kim, J., Wu, Y., Tunceli, O., Wu, B., Hirshberg, B. Tags: Poster Session I Source Type: research

Abstract 63: The Smoking Paradox in Patients Hospitalized with Coronary Artery Disease: Findings from Get With The Guidelines - CAD [Poster Session I]
Conclusion: Smoking continues to be a major risk factor for presenting with CAD at a much younger age and with fewer risk factors. It is likely that the continued modest association with lower in-hospital mortality in smokers in this analysis after adjustment reflects residual or unmeasured confounding. This apparent smoker’s paradox in CAD should not be interpreted as a benefit of cigarette smoking. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Ali, S. F., Smith, E. E., Bhatt, D. L., Pan, W., Fonarow, G. C., Schwamm, L. H. Tags: Poster Session I Source Type: research

Abstract 77: Statin Adherence and Persistence Among Japanese Patients With High Risk Vascular Disease: A Japan Claims Database Analysis [Poster Session I]
CONCLUSION: Statin use after HRVD diagnosis was modest and highest in ACS patients and patients with multiple affected vascular beds. Statin adherence was high among patients with HRVD in Japan. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Zhao, Z., McCollam, P. L., Davis, K. L., Meyers, J., Murakami, M. Tags: Poster Session I Source Type: research

Abstract 80: Patterns of Statin Use, Adherence, and Persistence among Elderly Patients with High-Risk Vascular Diseases [Poster Session I]
CONCLUSIONS: Statin adherence is suboptimal for elderly patients with HRVD and the patterns of statin adherence persist over time with little titration in doses. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Zhao, Z., Zhu, Y., Fang, Y., McCollam, P. L. Tags: Poster Session I Source Type: research

Abstract 110: Racial Differences in Heart Failure Outcomes [Poster Session I]
Conclusion: Compared with whites, black heart failure patients enrolled in this trial had higher self-reported quality of life at baseline. However, there were no racial differences in quality of life at 3 and 6 months and both blacks and whites experienced notable improvement in quality of life in the follow-up period. After adjustment for clustering and patient factors, no significant racial differences in mortality or rehospitalization rates were observed. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Qian, F., Parzynski, C. S., Chaudhry, S. I., Spertus, J. A., Krumholz, H. M. Tags: Poster Session I Source Type: research

Abstract 123: Patterns of Statin Use, Adherence, and Persistence among Patients in Working Age Patients With High-Risk Vascular Diseases: Findings from a Multi-Employer Claims Database [Poster Session I]
CONCLUSIONS: Nonadherence to statins is common for patients with HRVD, and the patterns of statin adherence persist over time with little titration in doses. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Zhao, Z., Zhu, Y., Fang, Y., McCollam, P. L. Tags: Poster Session I Source Type: research

Abstract 290: Comparison of Lipid Control in Patients with Coronary versus Peripheral Arterial Disease [Poster Session III]
Conclusion: Even though both PAD and CAD groups had mean LDL < 100mg/dL, we found that lipid control assessed by absolute mean lipid levels were significantly better in patients with CAD and combined PAD & CAD group. Thus, our study indicates that physicians tend to be more aggressive with lipid control in patients with a diagnosis of CAD when compared to patients with PAD alone. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Sharma, S., Thapa, R., Myers, T., Hu, C., Brimacombe, M., Vacek, J. L., Dawn, B., Gupta, K. Tags: Poster Session III Source Type: research

Abstract 359: Lack Of Blood Pressure Augmentation During Stress Testing Is Associated With Increased Mortality. [Poster Session III]
Conclusions: Failure to augment systolic blood pressure during exercise appears to be associated with increased mortality. Although ischemia on echocardiography and reduced exercise capacity are the stress test outcomes traditionally associated with poor prognosis, failure to augment blood pressure during exercise may be an important predictor of mortality as well. Additional studies of this subject are needed. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: D'Cruz, G., Rastogi, A., Yager, N., Bindra, A., Fein, S. A., Torosoff, M. Tags: Poster Session III Source Type: research

Smoking cessation and outcome in stable outpatients with coronary, cerebrovascular, or peripheral artery disease
Conclusions: Smoking cessation was associated with a significant decrease in mortality in patients with CAD, a non-significant decrease in those with CVD, and a non-significant increase in those with PAD. (Source: European Journal of Preventive Cardiology)
Source: European Journal of Preventive Cardiology - May 14, 2013 Category: Cardiology Authors: Alvarez, L. R., Balibrea, J. M., Surinach, J. M., Coll, R., Pascual, M. T., Toril, J., Lopez-Jimenez, L., Monreal, M., the FRENA Investigators Tags: Original scientific paper Source Type: research

Onychomycosis in close quarter living review of the literature
Summary Onychomycosis is defined as a fungal infection of the nail bed and/or nail plate. The prevalence of onychomycosis has increased dramatically as a worldwide condition in the twentieth century due to occlusive footwear, global wars and natural migration. Risk factors generally leading to onychomycosis development include bodily spread of dermatophyte and non‐dermatophyte tinea pedis, peripheral vascular disease, damaged nails via sports and trauma, older age, genetics, immunodeficiency and diabetes. Many publications discuss prevalence, symptoms and treatment of the disease in individual cases, hospitals or specifi...
Source: Mycoses - May 14, 2013 Category: Research Authors: Michael I. Gazes, Joshua Zeichner Tags: Review Article Source Type: research

Nilotinib Associated With Increased Peripheral Artery Disease Rate in CML
Two studies found higher rates of peripheral artery occlusive disease in nilotinib-treated chronic myeloid leukemia patients than in imatinib-treated patients. (Source: Cancer Network)
Source: Cancer Network - May 13, 2013 Category: Cancer & Oncology Source Type: news

Bilateral internal mammary artery bypass grafting: long-term clinical benefits in a series of 1000 patients
Conclusions Our longitudinal analysis presents encouraging data concerning operative risk of BIMA grafting and provides excellent long-term survival in appropriately selected patients. (Source: Heart)
Source: Heart - May 13, 2013 Category: Cardiology Authors: Popovic, B., Voillot, D., Maureira, P., Vanhuyse, F., Agrinier, N., Aliot, E., Folliguet, T., Villemot, J. P. Tags: Drugs: cardiovascular system, Interventional cardiology, Acute coronary syndromes, Epidemiology Cardiovascular surgery Source Type: research

Patient characteristics but not virulence factors discriminate between asymptomatic and symptomatic E. coli bacteriuria in the hospital
Conclusions: Asymptomatic E. coli bacteriuria in hospitalized patients was frequent and more common in patients with dementia and chronic pulmonary disease. Bacterial virulence factors could not discriminate symptomatic from asymptomatic bacteriurias. Asymptomatic E. coli bacteriuria cannot be predicted by virulence screening. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - May 10, 2013 Category: Infectious Diseases Authors: Jonas MarschallMarilyn PiccirilloBetsy FoxmanLixin ZhangDavid WarrenJeffrey Henderson Source Type: research

Percutaneous transluminal angioplasty for peripheral artery disease confers cardiorenal protection
& K Kario (Source: Journal of Human Hypertension)
Source: Journal of Human Hypertension - May 2, 2013 Category: Cardiology Authors: K EguchiA MurakamiT HoraguchiM KatoH MiyashitaK Kario Tags: peripheral artery disease percutaneous transluminal angioplasty augmentation index left ventricular mass index urinary albumin excretion ratio Source Type: research

Salvage of a free radial forearm flap by creation of an arteriovenous fistula at the distal arterial pedicle
Abstract Interdisciplinary approaches with infrainguinal bypass grafts and free flaps between the plastic and vascular surgery may well offer an opportunity for diabetic patients with peripheral vascular disease to salvage their critically affected limbs. A free flap transfer combined with an autologous vein graft can cover large tissue defects and simultaneously improve distal perfusion even in patients with arterial occlusive disease. We are presenting a case of bypass‐free radial forearm flap used to cover a foot defect in an old diabetic patient with peripheral arterial disease. The flap perfusion deteriorated signif...
Source: Microsurgery - May 2, 2013 Category: Surgery Authors: Ahmad M. Eweida, Werner Lang, Marweh Schmitz, Raymund E. Horch Tags: Case Report Source Type: research

Does Prior Coronary Bypass Surgery Present a Unique Risk for Reoperative Valve Surgery? [ORIGINAL ARTICLES: ADULT CARDIAC]
Conclusions A history of CABG does not appear to present a unique risk in reoperative valve surgery. The major determinant of adverse outcomes is morbidity, not prior bypass grafts. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Breglio, A., Anyanwu, A., Itagaki, S., Polanco, A., Adams, D. H., Chikwe, J. Tags: Coronary disease, Valve disease ORIGINAL ARTICLES: ADULT CARDIAC Source Type: research

Impact of polyvascular disease on clinical outcomes in patients undergoing coronary revascularization: An observation from the CREDO-Kyoto Registry Cohort-2
Abstract: Objective: Patients with coronary artery disease (CAD) often have prior stroke or concomitant extra-cardiac vascular disease (EVD) such as cerebral, aortic, or peripheral vascular disease. However, clinical outcomes after coronary revascularization in patients with polyvascular disease have not been fully elucidated.Methods: Among 15,263 patients undergoing first coronary revascularization enrolled in the CREDO-Kyoto registry Cohort-2 from January 2005 to December 2007, there were 1443 patients with prior stroke (stroke + CAD group), 974 patients with EVD (EVD + CAD group), 253 patients with both prior stroke...
Source: Atherosclerosis - April 29, 2013 Category: Cardiology Authors: Yuko Morikami, Masahiro Natsuaki, Takeshi Morimoto, Koh Ono, Yoshihisa Nakagawa, Yutaka Furukawa, Ryuzo Sakata, Masaki Aota, Yukikatsu Okada, Masahiko Onoe, Michio Kawasuji, Takaaki Koshiji, Hiroyuki Nakajima, Junichiro Nishizawa, Kazuo Yamanaka, Hiroyuki Tags: Intervention Source Type: research

Declining Walking Impairment Questionnaire Scores Are Associated With Subsequent Increased Mortality in Peripheral Artery Disease
Conclusions: Patients with PAD who experienced ≥20.0 point declines in the WIQ stair climbing, distance, and speed scores had a higher rate of all-cause mortality compared with those with less declines in each WIQ score. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - April 24, 2013 Category: Cardiology Authors: Atul Jain, Kiang Liu, Luigi Ferrucci, Michael H. Criqui, Lu Tian, Jack M. Guralnik, Huimin Tao, Mary M. McDermott Tags: Peripheral Vascular Disease Source Type: research

Postoperative Hyponatremia Predicts an Increase in Mortality and In-Hospital Complications after Cardiac Surgery
Background: The association between postoperative hyponatremia (Na < 135 mEq/L) and outcomes after cardiac surgery has not been established. We studied the prevalence of postoperative hyponatremia and its effects on outcomes after cardiac surgery.Study Design: We studied 4,850 patients who underwent cardiac surgery from 2002 to 2008. We used multivariable logistic and Cox regression analysis to study the association between postoperative hyponatremia and mortality, length of hospital stay (LOS), and complications.Results: Postoperative hyponatremia was present in 59%. Hyponatremic patients were older (mean ± SD, 62 ± 13 ...
Source: Journal of the American College of Surgeons - April 24, 2013 Category: Surgery Authors: Juan A. Crestanello, Gary Phillips, Michael S. Firstenberg, Chittoor Sai-Sudhakar, John Sirak, Robert Higgins, William T. Abraham Tags: Original Scientific Articles Source Type: research

Drug-Eluting Stents: High Marks in Peripheral Artery Disease Drug-Eluting Stents: High Marks in Peripheral Artery Disease
A meta-analysis covering the use of stents in patients with chronic lower limb ischemia showed superior results with drug-eluting stents compared with bare-metal stents. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 23, 2013 Category: Consumer Health News Tags: Radiology News Source Type: news

Declining Walking Impairment Questionnaire Scores Are Associated With Subsequent Increased Mortality in Peripheral Artery Disease
ConclusionsPatients with PAD who experienced ≥20.0 point declines in the WIQ stair climbing, distance, and speed scores had a higher rate of all-cause mortality compared with those with less declines in each WIQ score. (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - April 22, 2013 Category: Cardiology Source Type: research

Mortality advantage with CABG over PCI in Medicare patients
This reduction in mortality with CABG was significantly lower among patients with diabetes, a history of tobacco use, heart failure, and peripheral artery disease, providing strong evidence that clinical characteristics modify the CABG-PCI treatment effect, say researchers. (Source: theHeart.org)
Source: theHeart.org - April 22, 2013 Category: Cardiology Source Type: news

Peripheral artery disease is associated with severe impairment of vascular function
Patients with peripheral artery disease (PAD) have higher cardiovascular event rates than patients with established coronary artery disease (CAD) and abnormal endothelial function predicts cardiovascular risk in PAD and CAD. We investigated the hypothesis that PAD is associated with a greater degree of impairment in vascular function than CAD. We used several non-invasive tests to evaluate endothelial function in 1320 men and women with combined PAD and CAD (n = 198), PAD alone (n = 179), CAD alone (n = 466), or controls aged > 45 years without CAD or PAD (n = 477). Patients with PAD had lower brachial artery flow-media...
Source: Vascular Medicine recent issues - April 22, 2013 Category: Internal Medicine Authors: Kiani, S., Aasen, J. G., Holbrook, M., Khemka, A., Sharmeen, F., LeLeiko, R. M., Tabit, C. E., Farber, A., Eberhardt, R. T., Gokce, N., Vita, J. A., Hamburg, N. M. Tags: Original Articles Source Type: research

Plasma pentraxin 3 may be a better marker of peripheral artery disease in hemodialysis patients than C-reactive protein
In conclusion, we demonstrated that PTX3 may be a better marker of PAD than hsCRP, and independently correlated with PAD in HD patients. (Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - April 22, 2013 Category: Internal Medicine Authors: Zhou, Y., Ni, Z., Zhang, J., Zhang, W., Wu, Q., Shen, G., Wang, Y., Qian, J. Tags: Original Articles Source Type: research

Methods of symptom evaluation and their impact on peripheral artery disease (PAD) symptom prevalence: A review
Peripheral artery disease (PAD) is a common progressive atherosclerotic occlusive disease that causes insufficient blood flow to the lower extremities. The symptom that health care professionals most often associate with PAD is claudication. However, patient reporting of claudication is highly variable. A structured literature review was conducted to evaluate how PAD symptoms are identified, defined, and categorized. This review focuses on the development and performance characteristics of PAD symptom questionnaires and the identification of a spectrum of leg symptoms beyond classic claudication. Additionally, potential co...
Source: Vascular Medicine recent issues - April 22, 2013 Category: Internal Medicine Authors: Schorr, E. N., Treat-Jacobson, D. Tags: Review Article Source Type: research

Endovascular treatment of diseases of the common femoral artery: Lumpers and splitters
(Source: Catheterization and Cardiovascular Interventions)
Source: Catheterization and Cardiovascular Interventions - April 19, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Robert D. Safian Tags: Peripheral Vascular Disease Source Type: research

Keep out of jail: The reason to limit stent usage for the common femoral artery bifurcation
(Source: Catheterization and Cardiovascular Interventions)
Source: Catheterization and Cardiovascular Interventions - April 19, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Gary Ansel Tags: Peripheral Vascular Disease Source Type: research

You can get there from here! A novel virtual 4.5F guide facilitates renal intervention from transradial access
(Source: Catheterization and Cardiovascular Interventions)
Source: Catheterization and Cardiovascular Interventions - April 19, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Beau M. Hawkins, Douglas E. Drachman Tags: Peripheral Vascular Disease Source Type: research

Medical and psychological comorbidity predicts poor pain outcomes after total knee arthroplasty
Conclusion. This study identified medical and psychological comorbidity risk factors for moderate to severe pain after primary and revision TKA. This information can be used to provide realistic outcome expectations for patients before undergoing primary or revision TKA. (Source: Rheumatology)
Source: Rheumatology - April 19, 2013 Category: Rheumatology Authors: Singh, J. A., Lewallen, D. G. Tags: Psychology: Measurement and Management of Pain CLINICAL SCIENCE Source Type: research

Methods of accelerated atherosclerosis in diabetic patients
This article will focus on the effect of diabetes on the initiation and progression of arterial occlusive disease, preceded by a short outline of the enormous impact of this issue from a societal-economic perspective. Diabetes, a major healthcare issue The prevalence and associated costs of diabetes are expected to increase significantly. There are currently over 240... (Source: Heart)
Source: Heart - April 18, 2013 Category: Cardiology Authors: Pasterkamp, G. Tags: Diabetic heart disease, Health policy, Education in Heart, Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Stable coronary heart disease, Epidemiology, Diabetes, Metabolic disorders Source Type: research

Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusion
Conclusions: Oral treprostinil diethanolamine was effectively absorbed in patients with scleroderma. Drug administration was temporally associated with improved cutaneous perfusion and temperature. Treprostinil diethanolamine may provide a new therapeutic option for Raynaud's phenomenon and the peripheral vascular disease of scleroderma.Trial Registration: ClinicalTrials.gov NCT00848939. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 18, 2013 Category: Rheumatology Authors: Ami ShahElena SchiopuLaura HummersMichael WadeKristine PhillipsCynthia AndersonRobert WiseFrancesco BoinJames SeiboldFredrick WigleyKristan Rollins Source Type: research

The association of obesity with cardiovascular events in patients with peripheral artery disease
Conclusion: This meta-analysis suggests that obesity is an independent risk factor for CVEs in patients with PAD however larger and more homogeneous studies using equivalent anthropometric measures are needed for more definitive evidence. (Source: Atherosclerosis)
Source: Atherosclerosis - April 18, 2013 Category: Cardiology Authors: Oliver Cronin, Dylan R. Morris, Philip J. Walker, Jonathan Golledge Tags: Reviews Source Type: research

Testosterone and Sympathetic Nerve Activity During Pregnancy [Letters to the Editor]
(Source: Hypertension)
Source: Hypertension - April 17, 2013 Category: Cardiology Authors: Carter, J. R. Tags: Peripheral vascular disease, Endothelium/vascular type/nitric oxide Letters to the Editor Source Type: research

Mortality and Morbidity During and After Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial: Results by Sex [Clinical Trial - ALLHAT]
To determine whether an angiotensin-converting enzyme inhibitor (lisinopril) or calcium channel blocker (amlodipine) is superior to a diuretic (chlorthalidone) in reducing cardiovascular disease incidence in sex subgroups, we carried out a prespecified subgroup analysis of 15 638 women and 17 719 men in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Total follow-up (active treatment + passive surveillance using national administrative databases to ascertain deaths and hospitalizations) was 8 to 13 years. The primary outcome was fatal coronary heart disease or nonfatal myocardial i...
Source: Hypertension - April 17, 2013 Category: Cardiology Authors: Oparil, S., Davis, B. R., Cushman, W. C., Ford, C. E., Furberg, C. D., Habib, G. B., Haywood, L. J., Margolis, K., Probstfield, J. L., Whelton, P. K., Wright, J. T., for the ALLHAT Collaborative Research Group Tags: Primary prevention, Secondary prevention, Clinical Studies Clinical Trial - ALLHAT Source Type: research

Hemorrhagic and Ischemic Outcomes After Bivalirudin Versus Unfractionated Heparin During Carotid Artery Stenting: A Propensity Score Analysis From the NCDR [Peripheral Vascular Disease]
Conclusions— Bivalirudin was associated with lower rates of hemorrhagic outcomes compared with UFH during the index hospitalization for carotid artery stenting. In-hospital and 30-day ischemic events were similar between the 2 groups. Randomized comparisons of these agents are needed to confirm these findings. (Source: Circulation: Cardiovascular Interventions)
Source: Circulation: Cardiovascular Interventions - April 16, 2013 Category: Cardiology Authors: Wayangankar, S. A., Abu-Fadel, M. S., Aronow, H. D., Kennedy, K. F., Gupta, R., Yeh, R. W., Gray, W. A., Rosenfield, K., Hennebry, T. A. Tags: Heparin, Other anticoagulants, Carotid Stenosis, Angioplasty and Stenting, Transient Ischemic Attacks Peripheral Vascular Disease Source Type: research

Acetylcysteine for the Prevention of Renal Outcomes in Patients With Diabetes Mellitus Undergoing Coronary and Peripheral Vascular Angiography: A Substudy of the Acetylcysteine for Contrast-Induced Nephropathy Trial [Peripheral Vascular Disease]
Conclusions— In this subanalysis, acetylcysteine did not reduce the risk of contrast-induced acute kidney injury or other clinically relevant outcomes in patients with diabetes mellitus undergoing coronary and peripheral vascular angiography. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00736866. (Source: Circulation: Cardiovascular Interventions)
Source: Circulation: Cardiovascular Interventions - April 16, 2013 Category: Cardiology Authors: Berwanger, O., Cavalcanti, A. B., Sousa, A. M. G., Buehler, A., Castello-Junior, H. J., Cantarelli, M. J. C., Mangione, J. A., Bergo, R. R., Sao Thiago, L. E. K., Nunes, P. M. S., da Motta, P. A. M., Kodama, A., Victor, E., Carvalho, V. O., Sousa, J. E., Tags: Type 1 diabetes, Type 2 diabetes, Angiography Peripheral Vascular Disease Source Type: research

Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia
VEGF receptor (VEGFR) cell surface localization plays a critical role in transducing VEGF signaling toward angiogenic outcomes, and quantitative characterization of these parameters is critical to advancing computational models for predictive medicine. However, studies to this point have largely examined intact muscle; thus, essential data on the cellular localization of the receptors within the tissue are currently unknown. Therefore, our aims were to quantitatively analyze VEGFR localization on endothelial cells (ECs) from mouse hindlimb skeletal muscles after the induction of hindlimb ischemia, an established model for ...
Source: AJP: Heart and Circulatory Physiology - April 15, 2013 Category: Cardiology Authors: Imoukhuede, P. I., Dokun, A. O., Annex, B. H., Popel, A. S. Tags: VASCULAR BIOLOGY AND MICROCIRCULATION Source Type: research