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Rare Pancreatic Cancer Patients May Live Longer When Treated With Radiation Therapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Radiation therapy is effective in achieving local control and palliation in patients with pancreatic neuroendocrine tumors (PNTs), despite such tumors being commonly considered resistant to radiation therapy, according to a largest of its kind study in the November 15 issue of the International Journ (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 21, 2009 Category: Consumer Health News Tags: Pancreatic Cancer Source Type: news

Rare Pancreatic Cancer Patients May Live Longer When Treated With Radiation Therapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Radiation therapy is effective in achieving local control and palliation in patients with pancreatic neuroendocrine tumors (PNTs), despite such tumors being commonly considered resistant to radiation therapy, according to a largest of its kind study in the November 15 issue of the International Journal of Radiation Oncology Biology Physics, the official journal of the American Society for Radiation Oncology (ASTRO). (Source: Radiology / Nuclear Medicine News From Medical News Today)
Source: Radiology / Nuclear Medicine News From Medical News Today - November 21, 2009 Category: Radiology Tags: Pancreatic Cancer Source Type: news

Direct machine parameter optimization for intensity modulated radiation therapy (IMRT) of oropharyngeal cancer - a planning study.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The purpose of the study was to investigate the potential of direct machine parameter optimization (DMPO) to achieve parotid sparing without compromising target coverage in IMRT of oropharyngeal cancer as compared to fluence modulation with subsequent leaf sequencing (IM) and forward planned 2-step arc therapy (IMAT). IMRT plans were generated for 10 oropharyngeal cancer patients using DMPO and IM. The resulting dose volume histograms (DVH) were evaluated with regard to compliance with the dose volume objectives (DVO) and plan quality. DMPO met the DVO for the targets better than IM but violated the DVO to the parotids...
Source: Journal of Applied Clinical Medical Physics - November 20, 2009 Category: Physics Authors: Dobler B, Koelbl O, Bogner L, Pohl F Tags: J Appl Clin Med Phys Source Type: journals

The effect of interfraction prostate motion on IMRT plans: a dose-volume histogram analysis using a Gaussian error function model.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The Gaussian error function model, containing pairs of error and complementary error functions, was used to carry out cumulative dose-volume histogram (cDVH) analysis on prostate intensity modulated radiation therapy (IMRT) plans with interfraction prostate motion. Cumulative DVHs for clinical target volumes (CTVs) shifted in the anterior-posterior directions based on a 7-beam IMRT plan were calculated and modeled using the Pinnacle3 treatment planning system and a Gaussian error function, respectively. As the parameters in the error function model, namely, a, b and c were related to the shape of the cDVH curve, evalua...
Source: Journal of Applied Clinical Medical Physics - November 20, 2009 Category: Physics Authors: Chow JC, Jiang R, Markel D Tags: J Appl Clin Med Phys Source Type: journals

Optimization of photon beam energy in aperture-based inverse planning.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Optimal choice of beam energy in radiation therapy is easy in many well-documented cases, but less obvious in some others. Low-energy beams may provide better conformity around the target than their high-energy counterparts due to reduced lateral scatter, but they also contribute to overdosage of peripheral normal tissue. Beam energy was added as an optimization parameter in an automatic aperture-based inverse planning system. We have investigated two sites (prostate and lung), representative of deep-seated and moderately deep-seated tumors. For each case and different numbers of beam incidences, four plans were optimi...
Source: Journal of Applied Clinical Medical Physics - November 20, 2009 Category: Physics Authors: St-Hilaire J, Sévigny C, Beaulieu F, Gingras L, Tremblay D, Beaulieu L Tags: J Appl Clin Med Phys Source Type: journals

A diagnostic tool for basic daily quality assurance of a Tomotherapy Hi*Art machine.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: This tool makes it possible to perform an easy-to-use and fast basic daily quality assurance check featuring an output as well as an energy evaluation. Ideally this tool should offer also the combined dosimetry check of jaw width, couch speed, leaf latency, output, leaf/gantry synchrony and lasers. This will be investigated in the future. PMID: 19918225 [PubMed - in process] (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - November 20, 2009 Category: Physics Authors: Van de Vondel I, Tournel K, Verellen D, Duchateau M, Lelie S, Storme G Tags: J Appl Clin Med Phys Source Type: journals

Characterization of cylindrical ionization chambers for patient specific IMRT QA.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Proven conventional dosimetry techniques do not provide accuracy and precision in the measurement of inverse planned intensity modulated radiation therapy (IMRT) fields. Dynamic and step-and-shoot multileaf collimation (DMLC/SMLC) challenge current ionization chamber dosimetry practices. Ionization chamber performance in these fields is evaluated for three cylindrical chambers of varying volumes (PinPoint (PP): 0.015 cm3, IC10: 0.13 cm3, Farmer type NE2571 (FT): 0.69 cm3) in terms of measurement reproducibility, dose measurement linearity, and IMRT dose measurements. Fifty IMRT patient specific quality assurance dose m...
Source: Journal of Applied Clinical Medical Physics - November 20, 2009 Category: Physics Authors: Fraser DJ, Parker W, Seuntjens J Tags: J Appl Clin Med Phys Source Type: journals

Dose consumption for quality assurance and maintenance at a dedicated IORT accelerator.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Dedicated accelerators for intraoperative radiation therapy (IORT) are operated at high dose rates in order to achieve short treatment times within which the anaesthetisized patient must be remotely monitored, e.g. via video cameras and telemetric anesthesia instruments. Due to these high dose rates, large doses accumulate from the irradiations necessary for quality assurance (QA) and maintenance. In practice, the dose load for QA, maintenance and repairs will probably by far exceed the patient dose. The total dose consumption for all of these actions must be considered in facility licensing, in radiation protection as...
Source: Journal of Applied Clinical Medical Physics - November 20, 2009 Category: Physics Authors: Hensley FW Tags: J Appl Clin Med Phys Source Type: journals

The equivalence of multi-criteria methods for radiotherapy plan optimization.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Several methods can be used to achieve multi-criteria optimization of radiation therapy treatment planning, which strive for Pareto-optimality. The property of the solution being Pareto optimal is desired, because it guarantees that no criteria can be improved without deteriorating another criteria. The most widely used methods are the weighted-sum method, in which the different treatment objectives are weighted, and constrained optimization methods, in which treatment goals are set and the algorithm has to find the best plan fulfilling these goals. The constrained method used in this paper, the 2pc (2-phase -constrain...
Source: Physics in Medicine and Biology - November 20, 2009 Category: Physics Authors: Breedveld S, Storchi PR, Heijmen BJ Tags: Phys Med Biol Source Type: journals

Rare pancreatic cancer patients may live longer when treated with radiation therapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(American Society for Radiation Oncology) Radiation therapy is effective in achieving local control and palliation in patients with pancreatic neuroendocrine tumors, despite such tumors being commonly considered resistant to radiation therapy, according to a largest of its kind study in the Nov. 15 issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of the American Society for Radiation Oncology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 20, 2009 Category: Global & Universal Source Type: news

Dose-Rate Effects When Estimating Risks for Second Malignancies: In Regard to Fontenot et al (Int J Radiat Oncol Biol Phys 2009;74:616–622)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
To the Editor: In the work by Fontenot et al. , the risk for developing a second malignancy after prostate radiation therapy was estimated for proton therapy and intensity-modulated X-ray therapy (IMRT). The authors conclude that proton therapy can reduce the risk for a second cancer when compared with IMRT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Harald Paganetti, Basit S. Athar, Bryan Bednarz Tags: Letters to the Editor Source Type: journals

Respiratory Motion Changes of Lung Tumors Over the Course of Radiation Therapy Based on Respiration-Correlated Four-Dimensional Computed Tomography Scansemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Interfraction consistency in tumor excursion suggests tumor excursion at simulation may direct therapy. Significant variations in phase lag between GTV and other anatomic structures throughout treatment have important implications for techniques that rely on surrogate structures to predict tumor motion (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Kristin J. Redmond, Danny Y. Song, Jana L. Fox, Jessica Zhou, C. Nicole Rosenzweig, Eric Ford Tags: Physics Contributions Source Type: journals

Reconstruction of Mandibular Continuity Defects Using Recombinant Human Bone Morphogenetic Protein 2: A Note of Caution in an Atmosphere of Exuberanceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Loss of mandibular continuity most commonly occurs because of traumatic, infectious, or neoplastic processes and can be psychologically and physiologically debilitating. The goals of mandibular reconstruction are the restoration of appearance, mastication, deglutition, speech, and oral competence. Although the timing and prioritization of these goals within the context of ablative surgery have been controversial, it is clear that successful reconstruction of bony defects is dependent on the survival of the transplanted tissue, which in turn is dependent on an adequate blood supply or soft tissue envelope. Numerous reconstr...
Source: Journal of Oral and Maxillofacial Surgery - November 19, 2009 Category: ENT & OMF Authors: R. Bryan Bell, Curtis Gregoire Tags: Clinical Controversies in Oral and Maxillofacial Surgery: Part One Source Type: journals

Discontinuation of Radiation Treatment among Medicaid-Enrolled Women with Local and Regional Stage Breast Canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: For women with nonmetastatic breast cancer, radiation therapy is recommended as a necessary component of the breast conserving surgery (BCS) treatment option. The degree to which Medicaid-enrolled women complete recommended radiation therapy protocols is not known. We evaluate radiation treatment completion rates for Medicaid enrollees aged 18[ndash]64 diagnosed with breast cancer. We determine clinical and socio-demographic factors associated with not starting treatment, and with interruptions or not completing radiation treatment. Using data from the Washington State Cancer Registry linked to Medicaid enrollmen...
Source: The Breast Journal - November 19, 2009 Category: Cancer & Oncology Authors: Scott D. Ramsey, Steven B. Zeliadt, Lisa C. Richardson, Lori A. Pollack, Hannah Linden, David K. Blough, Mahesh Keitheri Cheteri, Lauri Tock, Krisztina Nagy, Nancy Anderson Source Type: journals

Radiation Improves Regional Melanoma Control After Lymphadenectomyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CHICAGO (EGMN) - Radiation therapy significantly reduced the risk of recurrence in melanoma patients at high risk of relapse after lymphadenectomy, according to a phase III intergroup trial.Among 217 fully... (Source: OncologySTAT Latest News)
Source: OncologySTAT Latest News - November 18, 2009 Category: Cancer & Oncology Source Type: news

RALP effective for radiation-resistant prostate canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Prostate cancer patients who experience disease recurrence after radiation therapy can be effectively treated with salvage robot assisted laparoscopic radical prostatectomy, research findings show. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - November 18, 2009 Category: Cancer & Oncology Source Type: news

Postsurgical H&N patients manage to complete radiotherapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Head and neck patients who undergo surgery first are more likely to complete radiation therapy, according to Seattle-based researchers. Megan Dann Fesinmeyer, PhD, MPH, and colleagues noted that radiation dose and treatment duration correlated with tumor control and survival, but that breaks in radiotherapy have been associated with inferior tumor control. (Source: Cancer Network)
Source: Cancer Network - November 18, 2009 Category: Cancer & Oncology Source Type: info

Pathologic complete response of a solitary melanoma brain metastasis after local ablative radiation therapy: case reportemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  A 73-year-old female with malignant melanoma metastatic to her left frontal lobe status post-gross total resection of the metastasis, whole brain radiotherapy, and Gamma Knife-based stereotactic radiosurgery for local recurrence presented with an area of increasing enhancement on follow-up magnetic resonance imaging (MRI) and hypermetabolic lesions on 18-fluorodeoxyglucose positron emission tomography/computerized tomography (18FDG PET/CT) of the brain suspicious for tumor recurrence. Surgical resection of the lesion was performed showing radiation necrosis with no evidence of tumor. The patient was...
Source: Medical Oncology - November 18, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Loco-regional control after postoperative radiotherapy for patients with regional nodal metastases from melanomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Despite the high incidence of distant metastases, loco-regional control remains an important goal in the management of melanoma. Surgery and adjuvant RT provides excellent loco-regional control, although distant metastases remain the major cause of mortality. Content Type Journal ArticleCategory Research ArticlesDOI 10.1007/s12094-009-0425-8Authors Carlos Conill, University of Barcelona Department of Radiation Oncology, Institute of Haematology and Oncology Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) C/Villarroel, 170 ES-08036 Barcelona SpainIzask...
Source: Clinical and Translational Oncology - November 18, 2009 Category: Cancer & Oncology Tags: Clinical and Translational Oncology Source Type: journals

Abscopal effect in a patient with chronic lymphocytic leukemia during radiation therapy: a case reportemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report a documented observation of Abscopal effect in a patient of Chronic Lymphocytic Leukemia during radiation therapy. (Source: BioMed Central)
Source: BioMed Central - November 18, 2009 Category: Journals (General) Authors: Preethi Bangalore LakshmangowdaLokesh ViswanathNaveen ThimmaiahLokanath DasappaSanjay Sudakar SupePramod Kallur Source Type: journals

A systematic review of proton therapy in the treatment of chondrosarcoma of the skull baseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Chondrosarcoma (CSA) of the skull base (SB) is an uncommon, slowly growing, neoplasm comprising approximately 0.1% of all intracranial tumors and 6% of SB lesions. Even though its growth is slow, CSA is a potentially lethal tumor. The therapeutic approach to CSA of the SB is still controversial and clinical experience is limited because of the relative rarity of this tumor. The use of proton therapy (PT) after maximal surgery is widely accepted, but there are no controlled studies demonstrating the need of PT and its superiority in comparison to radiotherapy with photons. We conducted a systematic r...
Source: Urosurgical Review - November 17, 2009 Category: Urology & Nephrology Tags: Neurosurgical Review Source Type: journals

Role of Radiation Therapy in Cutaneous Melanomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Cutaneous melanoma is a disease that often has an aggressive and unpredictable course. It was historically thought to be a radioresistant neoplasm; however, substantial radiobiologic and clinical evidence has emerged to refute this notion. Improved local control has been demonstrated with the use of adjuvant radiation therapy delivered to the primary site or regional lymphatics in patients with high-risk clinical or pathologic features. Despite improved local control, high-risk cutaneous melanoma often spreads systemically, leading to poor survival. In the setting of systemic progression, radiation therapy can frequently p...
Source: Clinics in Plastic Surgery - November 17, 2009 Category: Cosmetic Surgery Authors: Jaime H. Shuff, Malika L. Siker, Mackenzie D. Daly, Christopher J. Schultz Source Type: journals

Surgical Treatment of Advanced Melanomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article reviews the principles of patient selection and the potential benefits of surgical management of melanoma metastatic to various sites. Novel adjuvant therapies are being developed to augment the benefits of surgical treatment of advanced melanoma in the future. (Source: Clinics in Plastic Surgery)
Source: Clinics in Plastic Surgery - November 17, 2009 Category: Cosmetic Surgery Authors: Christopher J. Hussussian Source Type: journals

How cells tolerate DNA damage: Start signal for cell survival program identifiedemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Cancer researchers in Germany have gained new insights into how cells react to DNA damage. They have shown that the protein PARP-1, which detects DNA damage within seconds, activates the transcription factor NF-kappaB. NF-kappaB triggers a survival program, which blocks programmed cell death. The activation of NF-kappaB is thought to be one of the potential causes for tumor cell resistance to chemo and radiation therapy. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 17, 2009 Category: Science Source Type: news

RALP effective for radiation-resistant prostate canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Prostate cancer patients who experience disease recurrence after radiation therapy can be effectively treated with salvage robot assisted laparoscopic radical prostatectomy, research findings show. (Source: MedWire News - Prostate Cancer)
Source: MedWire News - Prostate Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news

Involvement of Mitochondrial DNA Sequence Variations and Respiratory Activity in Late Complications following Radiotherapy.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: Mitochondria contribute to radiation sensitivity, and genetic variations can be associated with late reactions to radiotherapy. Predictive markers of radiosensitivity should take into account mtDNA genetic variations in addition to variations in nuclear genes. (Clin Cancer Res 2009;15(23):OF1-9). PMID: 19920115 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 17, 2009 Category: Cancer & Oncology Authors: Alsbeih GA, Al-Harbi NM, El-Sebaie MM, Al-Rajhi NM, Al-Hadyan KS, Abu-Amero KK Tags: Clin Cancer Res Source Type: journals

Oncologic control obtained after radical prostatectomy in men with a pathological Gleason score >/= 8: A single-center experience.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: RP remains a possible therapeutic option in certain cases of the high-risk cohort of patients with a Gleason score >/= 8. However, patients should be warned that surgery might only be the first step of a multi-modal treatment approach. The modalities of adjuvant treatments and the right schedule to deliver it following RP still need to be defined. PMID: 19926312 [PubMed - as supplied by publisher] (Source: Urologic Oncology)
Source: Urologic Oncology - November 17, 2009 Category: Urology & Nephrology Authors: Audenet F, Comperat E, Seringe E, Drouin SJ, Richard F, Cussenot O, Bitker MO, Rouprêt M Tags: Urol Oncol Source Type: journals

Omitted Author Name in: Primary Treatment of Verrucous Carcinoma of the Penis With Fluorouracil, cis-Diamino-dichloro-platinum, and Radiation Therapy [Correction]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Archives of Dermatology)
Source: Archives of Dermatology - November 16, 2009 Category: Dermatology Tags: Oncology, Skin Cancer, Oncology, Other, Dermatology, Dermatologic Disorders, radiation therapy, Neoplasms, Drug Therapy, Drug Therapy, Other Correction Source Type: journals

N2 Disease in Patients With Head and Neck Squamous Cell Cancer Treated With Chemoradiotherapy: Is There a Role for Posttreatment Neck Dissection? [Original Article]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Posttreatment neck dissections may not be indicated for patients with N2 disease and a negative CT-PET result, even in patients with nodal necrosis and nodes 3 cm or larger. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - November 16, 2009 Category: ENT & OMF Authors: Cho, A. H., Shah, S., Ampil, F., Bhartur, S., Nathan, C.-A. O. Tags: Oncology, Head & Neck Cancer, Otolaryngology/ Head & Neck Surgery, Neoplasms of Head & Neck, Radiology of Head & Neck, radiation therapy, Radiologic Imaging, Surgery, Surgical Interventions, Surgical Oncology, PET/ SPECT Imaging, Drug Therapy, Drug Therap Source Type: journals

Early Prediction of Response to Chemoradiotherapy for Head and Neck Cancer: Reliability of Restaging With Combined Positron Emission Tomography and Computed Tomography [Original Article]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Negative PET-CT findings accurately determine early disease response at the primary site and in the neck. False-positive findings are common at the primary site. Patients with a negative PET-CT finding after the completion of intra-arterial CRT do not require surgical intervention. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - November 16, 2009 Category: ENT & OMF Authors: Malone, J. P., Gerberi, M. A. T., Vasireddy, S., Hughes, L. F., Rao, K., Shevlin, B., Kuhn, M., Collette, D., Tennenhouse, J., Robbins, K. T. Tags: Oncology, Head & Neck Cancer, Otolaryngology/ Head & Neck Surgery, Neoplasms of Head & Neck, Radiology of Head & Neck, radiation therapy, Radiologic Imaging, Prognosis/ Outcomes, PET/ SPECT Imaging, Drug Therapy, Drug Therapy, Other Original Article Source Type: journals

Predicting Residual Neck Disease in Patients With Oropharyngeal Squamous Cell Carcinoma Treated With Radiation Therapy: Utility of p16 Status [Original Article]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  In conjunction with other clinical parameters, p16 status can help predict the need for post-RT ND in patients with OP-SCCA. Although close observation may be warranted in selected patients with p16+ tumors, patients with p16– tumors are at much higher risk for residual neck disease, even when initial nodal disease is less advanced. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - November 16, 2009 Category: ENT & OMF Authors: Shonka, D. C., Shoushtari, A. N., Thomas, C. Y., Moskaluk, C., Read, P. W., Reibel, J. F., Levine, P. A., Jameson, M. J. Tags: Oncology, Head & Neck Cancer, Otolaryngology/ Head & Neck Surgery, Neoplasms of Head & Neck, radiation therapy, Papillomavirus, Human, Prognosis/ Outcomes Original Article Source Type: journals

Neck Response to Chemoradiotherapy: Complete Radiographic Response Correlates With Pathologic Complete Response in Locoregionally Advanced Head and Neck Cancer [Original Article]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Neck levels with residual disease on post-CRT CT imaging warrant removal. However, neck levels without evidence of disease on post-CRT CT imaging are unlikely to harbor cancer, which lends further support to the concept of basing neck dissection on post-CRT staging and performance of limited neck dissections for patients with limited residual disease. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - November 16, 2009 Category: ENT & OMF Authors: Langerman, A., Plein, C., Vokes, E. E., Salama, J. K., Haraf, D. J., Blair, E. A., Stenson, K. M. Tags: Oncology, Head & Neck Cancer, Otolaryngology/ Head & Neck Surgery, Neoplasms of Head & Neck, Radiology of Head & Neck, radiation therapy, Drug Therapy, Drug Therapy, Other Original Article Source Type: journals

Immune Response During Therapy With Cisplatin or Radiation for Human Papillomavirus-Related Head and Neck Cancer [Original Article]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  The HPV-positive tumors are not more curable based on increased epithelial sensitivity to cisplatin or radiation therapy. Instead, radiation and cisplatin induce an immune response to this antigenic cancer. The implications of these results may lead to novel therapies that enhance tumor eradication for HPV-positive cancers. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - November 16, 2009 Category: ENT & OMF Authors: Spanos, W. C., Nowicki, P., Lee, D. W., Hoover, A., Hostager, B., Gupta, A., Anderson, M. E., Lee, J. H. Tags: Oncology, Head & Neck Cancer, Oncology, Other, Otolaryngology/ Head & Neck Surgery, Neoplasms of Head & Neck, radiation therapy, Drug Therapy, Drug Therapy, Other, Immunology, Immunology, Other Original Article Source Type: journals

A 25-Year Analysis of Veterans Treated for Tonsillar Squamous Cell Carcinoma [Original Article]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  In veterans treated for tonsillar SCC, we advocate the consideration of a treatment plan that includes surgery for patients presenting with advanced-stage SCC of the tonsil, even in patients with notable comorbidities. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - November 16, 2009 Category: ENT & OMF Authors: Jaber, J. J., Moreira, J., Canar, W. J., Bier-Laning, C. M. Tags: Oncology, Head & Neck Cancer, Oncology, Other, Otolaryngology/ Head & Neck Surgery, Neoplasms of Head & Neck, Public Health, Tobacco, radiation therapy, Surgery, Surgical Interventions, Surgical Oncology, Prognosis/ Outcomes Original Article Source Type: journals

Postoperative Reirradiation for Mucosal Head and Neck Squamous Cell Carcinomas [Original Article]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Reirradiation represents the only chance for cure in patients with unresectable disease. After surgery, reirradiation is performed in patients at high risk of locoregional recurrence and may increase acute toxic effects. However, free-flap reconstruction may reduce toxic effects. Functional outcomes have declined since 2000 likely because of the addition of concurrent platinum-based chemotherapy. Future research may define the subpopulation of postoperative patients for whom survival benefits most outweigh reirradiation toxic effects. (Source: Archives of Otolaryngology)
Source: Archives of Otolaryngology - November 16, 2009 Category: ENT & OMF Authors: Iseli, T. A., Iseli, C. E., Rosenthal, E. L., Caudell, J. J., Spencer, S. A., Magnuson, J. S., Smith, A. N., Carroll, W. R. Tags: Oncology, Head & Neck Cancer, Oncology, Other, Otolaryngology/ Head & Neck Surgery, Neoplasms of Head & Neck, radiation therapy Original Article Source Type: journals

Medical physics aspects of particle therapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Charged particle beams offer an improved dose conformation to the target volume when compared with photon radiotherapy, with better sparing of normal tissue structures close to the target. In addition, beams of heavier ions exhibit a strong increase of the linear energy transfer in the Bragg peak when compared with the entrance region. These physical and biological properties make ion beams more favourable for radiation therapy of cancer than photon beams. As a consequence, particle therapy with protons and heavy ions has gained increasing interest worldwide. This contribution summarises the physical and biological princip...
Source: Radiation Protection Dosimetry - November 16, 2009 Category: Radiology Authors: Jakel, O. Tags: Articles Source Type: journals

Randomized Clinical Trials in Pancreatic Adenocarcinomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article critically reviews and ranks 107 prospective, randomized controlled trials (RCT) for pancreatic adenocarcinoma published between 2000 and 2008 identified through a standard MEDLINE literature search strategy, according to a standardized, previously published 3-tiered system (Ia, Ib, and Ic). All trials included in this article are Ia or Ib. Types of treatment reviewed include surgery, chemotherapy, molecular therapy, radiation therapy, immunotherapy, and palliative therapy. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Udo Rudloff, Ajay V. Maker, Murray F. Brennan, Peter J. Allen Source Type: journals

Stereotactic body radiation controls lung ca in frail patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CHICAGO—In lung cancer patients, stereotactic body radiation therapy achieved a 98% local control rate that persisted over three years in those who were too frail with comorbidities to undergo surgery, according to research presented at ASTRO 2009. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info

New technology unveiled at ASTRO 2009email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CHICAGO—Accuray introduced the CyberKnife VSI System. The system is designed to also include conventionally fractionated robotic intensity-modulated radiation therapy. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info

How cells tolerate DNA damage -- start signal for cell survival program identifiedemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Helmholtz Association of German Research Centres) Cancer researchers from the Max Delbrueck Center, Berlin, Germany, have gained new insights into how cells react to DNA damage. They have shown that the protein PARP-1, which detects DNA damage within seconds, activates the transcription factor NF-kappaB. NF-kappaB triggers a survival program, which blocks programmed cell death. The activation of NF-kappaB is thought to be one of the potential causes for tumor cell resistance to chemo and radiation therapy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 16, 2009 Category: Global & Universal Source Type: news

Infratentorial oligodendrogliomas: Imaging findings in six patients.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: Although infratentorial oligodendrogliomas did not show characteristic imaging findings, there was a tendency toward multifocal heterogeneous enhancement and absent or mild mass effect of infiltrative lesions. Infratentorial oligodendrogliomas may be more malignant than supratentorial oligodendrogliomas. PMID: 19912073 [PubMed - as supplied by publisher] (Source: Acta Radiologica)
Source: Acta Radiologica - November 16, 2009 Category: Radiology Authors: Lee IH, Kim ST, Suh YL, Kim HJ, Kim KH, Jeon P, Byun HS Tags: Acta Radiol Source Type: journals

Three-dimensional conformal radiation therapy for squamous cell carcinoma of the esophagus: A prospective phase I/II study.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: Although 3-DCRT to 66Gy for esophageal SCC was well tolerated, the local control was disappointing. The result supports the use of chemoradiation as the standard care for esophageal SCC. PMID: 19919886 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 16, 2009 Category: Radiology Authors: Wu KL, Chen GY, Xu ZY, Fu XL, Qian H, Jiang GL Tags: Radiother Oncol Source Type: journals

Low rate of thoracic toxicity in palliative paraspinal single-fraction stereotactic body radiation therapy.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: High-dose single-fraction SBRT is well tolerated to the thoracic region, with most patients tolerating high doses to central structures without significant toxicity. PMID: 19923027 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 16, 2009 Category: Radiology Authors: Gomez DR, Hunt MA, Jackson A, O'Meara WP, Bukanova EN, Zelefsky MJ, Yamada Y, Rosenzweig KE Tags: Radiother Oncol Source Type: journals

IMRT delivers high doses to prostate with satisfactory functional outcomesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Prostate cancer patients treated with intensity-modulated radiation therapy experience no significant worsening of urinary, sexual, or bowel function 5 years after treatment, Japanese researchers report. (Source: MedWire News - Prostate Cancer)
Source: MedWire News - Prostate Cancer - November 14, 2009 Category: Cancer & Oncology Source Type: news

Advances In Radiation Therapy Enable Doctors To Improve The Quality Of Treatments For Patients With Head And Neck Canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Clinical studies suggest that advanced treatments like intensity-modulated radiotherapy (IMRT) and image-guided radiotherapy (IGRT) are enabling radiation oncologists to enhance post-treatment health-related quality of life for patients with head and neck cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 14, 2009 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Advances In Radiation Therapy Enable Doctors To Improve The Quality Of Treatments For Patients With Head And Neck Canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Clinical studies suggest that advanced treatments like intensity-modulated radiotherapy (IMRT) and image-guided radiotherapy (IGRT) are enabling radiation oncologists to enhance post-treatment health-related quality of life for patients with head and neck cancer. In an educational session for radiotherapy professionals, delivered by two noted experts during the annual meeting of the American Society for Radiation Oncology (ASTRO) in Chicago last week, Avraham Eisbruch, M.D. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 14, 2009 Category: Cancer & Oncology Tags: Cancer / Oncology Source Type: news

SAVI Breast Cancer Radiation Therapy Is A Unique Solution, Study Findsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The SAVI 6-1Mini breast brachytherapy applicator is the only brachytherapy solution for patients with small breasts, hard-to-reach lumpectomy cavities, or cavities close to the skin surface, according to a new study. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - November 14, 2009 Category: Cancer & Oncology Source Type: news

Revisiting the prognostic value of preoperative 18F-fluoro-2-deoxyglucose (18F-FDG) positron emission tomography (PET) in early-stage (I & II) non-small cell lung cancers (NSCLC)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Each doubling of SUVmax as determined by preoperative PET is associated with a 1.28-fold increase in hazard of death in early-stage (I & II) NSCLC. Preoperative SUVmax is not an independent predictor of overall survival. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1291-xAuthors Mohit Agarwal, Oakland University William Beaumont School of Medicine Hospital Department of Internal Medicine 3601 W 13 Mile Rd Royal Oak MI 48073-6769 USAGovinda Brahmanday, Oakland University William Beaumont School of Medicine Hospital Department of Internal Medicine 3601 W 13 Mile ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 13, 2009 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

A Proposed Methodology to Select Radioisotopes for Use in Radionuclide Therapy [METHODOLOGIC PERSPECTIVES]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
SUMMARY: The American Journal of Neuroradiology has played a seminal role in the history of vertebral augmentation (VA). Because VA is increasingly being included in the multidisciplinary management of malignant vertebral compression fractures (VCFs), combined therapeutic approaches that include strategies to treat metastatic disease along with the fracture have become appealing options for patients. To that end, we recently investigated the dosimetric feasibility of treating malignant VCFs with radionuclide therapy. The goal would be to provide local control of the systemic disease beyond the pain relief and structural su...
Source: American Journal of Neuroradiology - November 13, 2009 Category: Radiology Authors: Cuaron, J.J., Hirsch, J.A., Medich, D.C., Rosenstein, B.S., Martel, C.B., Hirsch, A.E. Tags: METHODOLOGIC PERSPECTIVES Source Type: journals

Focal Neuronal Gigantism: A Rare Complication of Therapeutic Radiation [BRAIN]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report this rare delayed complication in a patient following treatment of a right frontal anaplastic oligodendroglioma. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - November 13, 2009 Category: Radiology Authors: Gaughen, J.R., Bourne, T.D., Aregawi, D., Shah, L.M., Schiff, D. Tags: BRAIN Source Type: journals